DHX57

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)5.09370710
2locomotory exploration behavior (GO:0035641)4.74827067
3centriole replication (GO:0007099)4.67404561
4microtubule depolymerization (GO:0007019)4.58536734
5protein polyglutamylation (GO:0018095)4.53928027
6synaptic vesicle maturation (GO:0016188)4.51254590
7sperm motility (GO:0030317)4.50539807
8epithelial cilium movement (GO:0003351)4.37389418
9cilium or flagellum-dependent cell motility (GO:0001539)4.34541263
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.30546686
11regulation of centriole replication (GO:0046599)4.28145212
12axonemal dynein complex assembly (GO:0070286)4.19793458
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.19667206
14cell migration in hindbrain (GO:0021535)4.08311187
15cilium movement (GO:0003341)4.03882632
16acrosome reaction (GO:0007340)3.98496295
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.93326358
18microtubule polymerization or depolymerization (GO:0031109)3.92578945
19regulation of cilium movement (GO:0003352)3.90728053
20pyrimidine nucleobase catabolic process (GO:0006208)3.82423504
21motile cilium assembly (GO:0044458)3.81424102
22synaptic vesicle docking involved in exocytosis (GO:0016081)3.78262343
23dendrite morphogenesis (GO:0048813)3.77258531
24exploration behavior (GO:0035640)3.74121616
25behavioral response to nicotine (GO:0035095)3.73684426
26centriole assembly (GO:0098534)3.73285834
27clathrin coat assembly (GO:0048268)3.71250138
28spermatid development (GO:0007286)3.57158637
29nuclear pore complex assembly (GO:0051292)3.54176564
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.49763773
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.42829117
32proline transport (GO:0015824)3.41383795
33vocalization behavior (GO:0071625)3.39572856
34synaptic vesicle exocytosis (GO:0016079)3.38477038
35regulation of synaptic vesicle exocytosis (GO:2000300)3.35806787
36axoneme assembly (GO:0035082)3.34975269
37regulation of glutamate receptor signaling pathway (GO:1900449)3.33669790
38glutamate secretion (GO:0014047)3.33324838
39chromosome condensation (GO:0030261)3.33016525
40DNA double-strand break processing (GO:0000729)3.31827242
41establishment of nucleus localization (GO:0040023)3.27586177
42microtubule severing (GO:0051013)3.27181159
43DNA packaging (GO:0006323)3.26884794
44nuclear pore organization (GO:0006999)3.26152184
45regulation of ARF protein signal transduction (GO:0032012)3.20965985
46cytoplasmic mRNA processing body assembly (GO:0033962)3.20300658
47central nervous system projection neuron axonogenesis (GO:0021952)3.20076373
48protein localization to synapse (GO:0035418)3.17613827
49pre-miRNA processing (GO:0031054)3.16976537
50regulation of centrosome duplication (GO:0010824)3.16768149
51dendritic spine morphogenesis (GO:0060997)3.16537776
52regulation of NFAT protein import into nucleus (GO:0051532)3.16036986
53axon extension (GO:0048675)3.15967828
54regulation of synapse structural plasticity (GO:0051823)3.14108734
55activation of protein kinase A activity (GO:0034199)3.13751086
56regulation of DNA endoreduplication (GO:0032875)3.13450393
57nucleobase catabolic process (GO:0046113)3.10257638
58cilium organization (GO:0044782)3.09406019
59cerebellar Purkinje cell differentiation (GO:0021702)3.04454419
60meiotic chromosome segregation (GO:0045132)3.04314103
61vesicle transport along microtubule (GO:0047496)3.03531684
62single strand break repair (GO:0000012)3.03253834
63axonal fasciculation (GO:0007413)3.01624607
64cilium assembly (GO:0042384)3.00760198
65regulation of gene silencing by RNA (GO:0060966)2.98769535
66regulation of posttranscriptional gene silencing (GO:0060147)2.98769535
67regulation of gene silencing by miRNA (GO:0060964)2.98769535
68nonmotile primary cilium assembly (GO:0035058)2.98404870
69positive regulation of synapse maturation (GO:0090129)2.98019995
70pore complex assembly (GO:0046931)2.95411570
71spermatid nucleus differentiation (GO:0007289)2.94832410
72organelle transport along microtubule (GO:0072384)2.93237644
73regulation of centrosome cycle (GO:0046605)2.92792455
74sperm-egg recognition (GO:0035036)2.89370380
75regulation of dendritic spine morphogenesis (GO:0061001)2.89309373
76innervation (GO:0060384)2.89123534
77negative regulation of histone methylation (GO:0031061)2.88494383
78insulin-like growth factor receptor signaling pathway (GO:0048009)2.87911354
79intraciliary transport (GO:0042073)2.87432582
80negative regulation of cell killing (GO:0031342)2.85885030
81negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.85885030
82ventricular system development (GO:0021591)2.85505379
83dopamine receptor signaling pathway (GO:0007212)2.84776885
84mitochondrion transport along microtubule (GO:0047497)2.84701462
85establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.84701462
86regulation of synaptic vesicle transport (GO:1902803)2.82955234
87neurotransmitter secretion (GO:0007269)2.82905608
88neuron recognition (GO:0008038)2.80768188
89neuron projection extension (GO:1990138)2.80529379
90positive regulation of dendritic spine morphogenesis (GO:0061003)2.80163485
91neuron cell-cell adhesion (GO:0007158)2.79157554
92positive regulation of axon extension (GO:0045773)2.78387465
93rRNA methylation (GO:0031167)2.78044410
94regulation of hippo signaling (GO:0035330)2.76390220
95protein targeting to Golgi (GO:0000042)2.72589639
96histone exchange (GO:0043486)2.72280315
97glial cell proliferation (GO:0014009)2.71738756
98regulation of long-term neuronal synaptic plasticity (GO:0048169)2.71734407
99negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.70127477
100negative regulation of translation, ncRNA-mediated (GO:0040033)2.70127477
101regulation of translation, ncRNA-mediated (GO:0045974)2.70127477
102negative regulation of sodium ion transport (GO:0010766)2.70015340
103neuromuscular process controlling balance (GO:0050885)2.69037519
104multicellular organism reproduction (GO:0032504)2.68944358
105replication fork processing (GO:0031297)2.68870033
106neural tube formation (GO:0001841)2.68682473
107establishment of protein localization to Golgi (GO:0072600)2.68193120
108G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.67854311
109glucocorticoid receptor signaling pathway (GO:0042921)2.67279311
110regulation of neuronal synaptic plasticity (GO:0048168)2.67196858
111retrograde transport, vesicle recycling within Golgi (GO:0000301)2.66519323
112stress granule assembly (GO:0034063)2.66464631
113negative regulation of microtubule polymerization (GO:0031115)2.65563931
114peptidyl-threonine dephosphorylation (GO:0035970)2.64081962
115microtubule anchoring (GO:0034453)2.64078296
116microtubule nucleation (GO:0007020)2.63069521
117cilium morphogenesis (GO:0060271)2.61541162
118ncRNA catabolic process (GO:0034661)2.61090811
119resolution of meiotic recombination intermediates (GO:0000712)2.60316932
120synaptic vesicle endocytosis (GO:0048488)2.58340318
121ionotropic glutamate receptor signaling pathway (GO:0035235)2.58156187
122retinal cone cell development (GO:0046549)2.56483729
123regulation of microtubule-based movement (GO:0060632)2.55972982
124microtubule organizing center organization (GO:0031023)2.55954589
125binding of sperm to zona pellucida (GO:0007339)2.55084008
126cytoskeletal anchoring at plasma membrane (GO:0007016)2.51422316
127centrosome organization (GO:0051297)2.51105915
128photoreceptor cell maintenance (GO:0045494)2.50661043
129regulation of ARF GTPase activity (GO:0032312)2.50278244
130brain morphogenesis (GO:0048854)2.49760559
131synapsis (GO:0007129)2.49701173
132axon cargo transport (GO:0008088)2.49236981
133protein localization to Golgi apparatus (GO:0034067)2.48841803
134NLS-bearing protein import into nucleus (GO:0006607)2.48751677
135sodium ion export (GO:0071436)2.48383177
136microtubule bundle formation (GO:0001578)2.47679309
137negative regulation of DNA-dependent DNA replication (GO:2000104)2.47388495
138reciprocal DNA recombination (GO:0035825)2.47384620
139reciprocal meiotic recombination (GO:0007131)2.47384620
140double-strand break repair via homologous recombination (GO:0000724)2.45941147
141peptidyl-lysine dimethylation (GO:0018027)2.45765532
142recombinational repair (GO:0000725)2.45462084
143cell proliferation in forebrain (GO:0021846)2.43675021
144prepulse inhibition (GO:0060134)2.42734046
145positive regulation of fibroblast migration (GO:0010763)2.42151321
146male gamete generation (GO:0048232)2.41018400
147regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.40964241
148limb development (GO:0060173)2.40951820
149appendage development (GO:0048736)2.40951820
150cellular component assembly involved in morphogenesis (GO:0010927)2.40791057
151spermatogenesis (GO:0007283)2.40355508
152sperm capacitation (GO:0048240)2.40345421
153protein localization to cilium (GO:0061512)2.39998034
154cell communication by electrical coupling (GO:0010644)2.39082059
155negative regulation of oligodendrocyte differentiation (GO:0048715)2.38542375
156central nervous system neuron axonogenesis (GO:0021955)2.38003297
157regulation of cAMP-dependent protein kinase activity (GO:2000479)2.37878559
158regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.37814878
159adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.37578544
160non-recombinational repair (GO:0000726)2.36491870
161double-strand break repair via nonhomologous end joining (GO:0006303)2.36491870
162rRNA modification (GO:0000154)2.36427687
163postsynaptic membrane organization (GO:0001941)2.35662775
164left/right axis specification (GO:0070986)2.35561556
165smoothened signaling pathway (GO:0007224)2.34986592
166paraxial mesoderm development (GO:0048339)2.34748241
167suckling behavior (GO:0001967)2.34245529
168corticosteroid receptor signaling pathway (GO:0031958)2.34114688
169protein-DNA complex disassembly (GO:0032986)2.33910525
170nucleosome disassembly (GO:0006337)2.33910525
171histone H3-K9 methylation (GO:0051567)2.33603683
172cerebellum development (GO:0021549)2.33350578
173peptidyl-threonine phosphorylation (GO:0018107)2.33263630
174negative regulation of organelle assembly (GO:1902116)2.32636110
175nerve growth factor signaling pathway (GO:0038180)2.32486583
176somatic diversification of immune receptors via somatic mutation (GO:0002566)2.31933294
177somatic hypermutation of immunoglobulin genes (GO:0016446)2.31933294
178histone H3-K9 demethylation (GO:0033169)2.31500225
179fusion of sperm to egg plasma membrane (GO:0007342)2.31442686
180sister chromatid cohesion (GO:0007062)2.30976249
181regulation of clathrin-mediated endocytosis (GO:2000369)2.30042768
182sister chromatid segregation (GO:0000819)2.29369529
183regulation of development, heterochronic (GO:0040034)2.29037127
184rRNA catabolic process (GO:0016075)2.29036163
185nucleus localization (GO:0051647)2.28050472
186regulation of axon extension (GO:0030516)2.26770054
187negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.26285613
188cerebellar Purkinje cell layer development (GO:0021680)2.26111686
189positive regulation of filopodium assembly (GO:0051491)2.25376554
190synaptic transmission, glutamatergic (GO:0035249)2.25187463
191auditory behavior (GO:0031223)2.24349235
192response to pheromone (GO:0019236)2.24306527
193neuron projection morphogenesis (GO:0048812)2.22309272
194establishment of mitochondrion localization (GO:0051654)2.22229563
195neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.21726540

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.22442141
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.14878701
3FUS_26573619_Chip-Seq_HEK293_Human2.69649916
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.69320651
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.59694346
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.57920930
7IGF1R_20145208_ChIP-Seq_DFB_Human2.42090142
8VDR_22108803_ChIP-Seq_LS180_Human2.37482590
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35899182
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.29046546
11TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.21738682
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18451104
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15468702
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.14089681
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13170111
16DROSHA_22980978_ChIP-Seq_HELA_Human2.11663086
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09913891
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.09323525
19* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.07670223
20TAF15_26573619_Chip-Seq_HEK293_Human2.05419111
21P300_19829295_ChIP-Seq_ESCs_Human2.04159292
22DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.03411012
23WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.02336009
24ZFP281_18757296_ChIP-ChIP_E14_Mouse2.01872082
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01830002
26EWS_26573619_Chip-Seq_HEK293_Human2.01026200
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.00726465
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99378647
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97727526
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92387079
31GBX2_23144817_ChIP-Seq_PC3_Human1.92354768
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.91307628
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.84749540
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.84129939
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83207533
36ZFP281_27345836_Chip-Seq_ESCs_Mouse1.81786650
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.81631369
38CBP_20019798_ChIP-Seq_JUKART_Human1.81631369
39E2F7_22180533_ChIP-Seq_HELA_Human1.80543407
40REST_21632747_ChIP-Seq_MESCs_Mouse1.77224930
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72835622
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72835622
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.71339491
44KDM2B_26808549_Chip-Seq_K562_Human1.70815286
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.69156426
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69137153
47SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.68560585
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.68270831
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67483157
50MYC_22102868_ChIP-Seq_BL_Human1.67187584
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.66975344
52ER_23166858_ChIP-Seq_MCF-7_Human1.65916735
53KDM2B_26808549_Chip-Seq_DND41_Human1.60960678
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.60562174
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58228121
56SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.56667824
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56557599
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56016904
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.55581070
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54847462
61MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53579068
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52711975
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.51736052
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51326079
65SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.50473670
66JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49965855
67AHR_22903824_ChIP-Seq_MCF-7_Human1.49698497
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.49033691
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.48214003
70IRF1_19129219_ChIP-ChIP_H3396_Human1.46869057
71AR_21572438_ChIP-Seq_LNCaP_Human1.46600852
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43590006
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.43466597
74KDM2B_26808549_Chip-Seq_JURKAT_Human1.42392146
75AR_19668381_ChIP-Seq_PC3_Human1.41849568
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.41833453
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41271286
78SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40820688
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39382019
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.38322972
81FOXM1_23109430_ChIP-Seq_U2OS_Human1.38311326
82FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.37535673
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.37522127
84ZNF274_21170338_ChIP-Seq_K562_Hela1.37508593
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.36095545
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33331652
87EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33304795
88HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32543412
89SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.30300740
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29140337
91TCF7_22412390_ChIP-Seq_EML_Mouse1.28890255
92EZH2_27294783_Chip-Seq_ESCs_Mouse1.28072049
93TP53_16413492_ChIP-PET_HCT116_Human1.27358152
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27014143
95YAP1_20516196_ChIP-Seq_MESCs_Mouse1.26726967
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26147811
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25061501
98SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24693341
99RUNX2_22187159_ChIP-Seq_PCA_Human1.24331585
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24075467
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23639348
102PKCTHETA_26484144_Chip-Seq_BREAST_Human1.23293591
103CBX2_27304074_Chip-Seq_ESCs_Mouse1.22096954
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22075609
105SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21254183
106PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20998759
107STAT3_23295773_ChIP-Seq_U87_Human1.19153595
108ISL1_27105846_Chip-Seq_CPCs_Mouse1.19057938
109SMAD4_21799915_ChIP-Seq_A2780_Human1.18527396
110SMAD4_21741376_ChIP-Seq_EPCs_Human1.18517993
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18088660
112RING1B_27294783_Chip-Seq_NPCs_Mouse1.17766992
113KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14890619
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12873887
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12042059
116CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11437249
117IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11356276
118CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10661980
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10483221
120KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10105322
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09868837
122DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09286996
123POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08824038
124BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07632659
125MYC_18940864_ChIP-ChIP_HL60_Human1.07562533
126SOX9_26525672_Chip-Seq_HEART_Mouse1.07228812
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07193665
128SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06780302
129STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06514618
130TBL1_22424771_ChIP-Seq_293T_Human1.06141814
131TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06053460
132RNF2_27304074_Chip-Seq_NSC_Mouse1.05980623
133P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05865430
134JUN_21703547_ChIP-Seq_K562_Human1.05524465
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05466894
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05216763
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05216763
138TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04960118
139PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04665546
140RING1B_27294783_Chip-Seq_ESCs_Mouse1.04368532
141WDR5_24793694_ChIP-Seq_LNCAP_Human1.04339540
142ELK1_19687146_ChIP-ChIP_HELA_Human1.04169212
143TCF4_22108803_ChIP-Seq_LS180_Human1.03591608
144NOTCH1_21737748_ChIP-Seq_TLL_Human1.03345127
145AR_25329375_ChIP-Seq_VCAP_Human1.03246641
146KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02444046
147FLI1_21867929_ChIP-Seq_TH2_Mouse1.01273052
148TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00062490
149SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99291761
150RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99275814
151SMAD3_21741376_ChIP-Seq_ESCs_Human0.98729778
152TCF4_18268006_ChIP-ChIP_LS174T_Human0.98326565
153RXR_22108803_ChIP-Seq_LS180_Human0.97459312
154NANOG_18555785_Chip-Seq_ESCs_Mouse0.97069959
155CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96832799
156ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96792969
157* TCF4_23295773_ChIP-Seq_U87_Human0.96504862
158PIAS1_25552417_ChIP-Seq_VCAP_Human0.95973630
159STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95685992
160ETV1_20927104_ChIP-Seq_GIST48_Human0.95273108
161TP53_22573176_ChIP-Seq_HFKS_Human0.95196598
162ERG_21242973_ChIP-ChIP_JURKAT_Human0.94532828
163TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94185529
164NFYB_21822215_ChIP-Seq_K562_Human0.93973687
165BCAT_22108803_ChIP-Seq_LS180_Human0.93913178
166FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93131552
167NFE2_27457419_Chip-Seq_LIVER_Mouse0.92940232
168P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92656023

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.53155159
2MP0000569_abnormal_digit_pigmentation5.27718612
3MP0004270_analgesia3.39666365
4MP0003787_abnormal_imprinting3.36731968
5MP0003635_abnormal_synaptic_transmissio2.92918053
6MP0009780_abnormal_chondrocyte_physiolo2.74891362
7MP0005410_abnormal_fertilization2.62528958
8MP0006292_abnormal_olfactory_placode2.61266564
9MP0002063_abnormal_learning/memory/cond2.38616012
10MP0003878_abnormal_ear_physiology2.35215174
11MP0005377_hearing/vestibular/ear_phenot2.35215174
12MP0000778_abnormal_nervous_system2.32139798
13MP0004858_abnormal_nervous_system2.30824179
14MP0002102_abnormal_ear_morphology2.00922407
15MP0005076_abnormal_cell_differentiation2.00852452
16MP0002734_abnormal_mechanical_nocicepti1.99286521
17MP0004811_abnormal_neuron_physiology1.94964064
18MP0002184_abnormal_innervation1.94495761
19MP0003121_genomic_imprinting1.93544222
20MP0001968_abnormal_touch/_nociception1.91227330
21MP0003122_maternal_imprinting1.91145879
22MP0002909_abnormal_adrenal_gland1.90809348
23MP0010234_abnormal_vibrissa_follicle1.87343541
24MP0003937_abnormal_limbs/digits/tail_de1.86961668
25MP0003136_yellow_coat_color1.86207003
26MP0008877_abnormal_DNA_methylation1.84311898
27MP0003698_abnormal_male_reproductive1.74051649
28MP0010094_abnormal_chromosome_stability1.73262866
29MP0001929_abnormal_gametogenesis1.72851384
30MP0003646_muscle_fatigue1.71117002
31MP0006072_abnormal_retinal_apoptosis1.70915640
32MP0002735_abnormal_chemical_nociception1.69324924
33MP0008058_abnormal_DNA_repair1.68978294
34MP0009745_abnormal_behavioral_response1.68249555
35MP0008961_abnormal_basal_metabolism1.67779738
36MP0003718_maternal_effect1.67340833
37MP0002572_abnormal_emotion/affect_behav1.65559757
38MP0000955_abnormal_spinal_cord1.65222457
39MP0005423_abnormal_somatic_nervous1.64493722
40MP0008789_abnormal_olfactory_epithelium1.63894357
41MP0002733_abnormal_thermal_nociception1.63102537
42MP0001293_anophthalmia1.60653263
43MP0005253_abnormal_eye_physiology1.59812899
44MP0005551_abnormal_eye_electrophysiolog1.59755664
45MP0003705_abnormal_hypodermis_morpholog1.58920154
46MP0010352_gastrointestinal_tract_polyps1.58120720
47MP0008057_abnormal_DNA_replication1.57946149
48MP0000049_abnormal_middle_ear1.56278188
49MP0003880_abnormal_central_pattern1.52349086
50MP0002837_dystrophic_cardiac_calcinosis1.49903444
51MP0002234_abnormal_pharynx_morphology1.47308245
52MP0002233_abnormal_nose_morphology1.45405625
53MP0002064_seizures1.42662397
54MP0000534_abnormal_ureter_morphology1.42129506
55MP0003123_paternal_imprinting1.41399604
56MP0001299_abnormal_eye_distance/1.40335485
57MP0000427_abnormal_hair_cycle1.40167652
58MP0002557_abnormal_social/conspecific_i1.39814753
59MP0003303_peritoneal_inflammation1.38857357
60MP0003183_abnormal_peptide_metabolism1.37290479
61MP0001286_abnormal_eye_development1.36559489
62MP0005187_abnormal_penis_morphology1.32795678
63MP0005248_abnormal_Harderian_gland1.32680579
64MP0002210_abnormal_sex_determination1.31023066
65MP0002152_abnormal_brain_morphology1.29117421
66MP0003329_amyloid_beta_deposits1.28993071
67MP0003077_abnormal_cell_cycle1.28240125
68MP0003119_abnormal_digestive_system1.27085624
69MP0004957_abnormal_blastocyst_morpholog1.27017005
70MP0004233_abnormal_muscle_weight1.26361384
71MP0003861_abnormal_nervous_system1.26029973
72MP0003755_abnormal_palate_morphology1.24738074
73MP0008932_abnormal_embryonic_tissue1.24346577
74MP0002938_white_spotting1.23817861
75MP0001486_abnormal_startle_reflex1.23200708
76MP0002160_abnormal_reproductive_system1.22881662
77MP0009703_decreased_birth_body1.22754887
78MP0003111_abnormal_nucleus_morphology1.22560823
79MP0002282_abnormal_trachea_morphology1.21384501
80MP0000537_abnormal_urethra_morphology1.20082532
81MP0005391_vision/eye_phenotype1.19632025
82MP0001970_abnormal_pain_threshold1.19302943
83MP0004885_abnormal_endolymph1.18391781
84MP0002736_abnormal_nociception_after1.17656052
85MP0009046_muscle_twitch1.17326017
86MP0001485_abnormal_pinna_reflex1.14661354
87MP0005389_reproductive_system_phenotype1.14658249
88MP0003890_abnormal_embryonic-extraembry1.14301195
89MP0003283_abnormal_digestive_organ1.13666584
90MP0002882_abnormal_neuron_morphology1.13219779
91MP0003693_abnormal_embryo_hatching1.12701217
92MP0004133_heterotaxia1.12544894
93MP0003942_abnormal_urinary_system1.08629151
94MP0004924_abnormal_behavior1.08412322
95MP0005386_behavior/neurological_phenoty1.08412322
96MP0008569_lethality_at_weaning1.07875375
97MP0002751_abnormal_autonomic_nervous1.07354718
98MP0001919_abnormal_reproductive_system1.07011092
99MP0010030_abnormal_orbit_morphology1.06660779
100MP0003300_gastrointestinal_ulcer1.05910347
101MP0001145_abnormal_male_reproductive1.05344730
102MP0002697_abnormal_eye_size1.05155923
103MP0005623_abnormal_meninges_morphology1.04156788
104MP0002067_abnormal_sensory_capabilities1.04051265
105MP0000653_abnormal_sex_gland1.02991151
106MP0005646_abnormal_pituitary_gland1.02733219
107MP0002161_abnormal_fertility/fecundity1.01176227
108MP0009672_abnormal_birth_weight1.00318090
109MP0004742_abnormal_vestibular_system0.99460502
110MP0003091_abnormal_cell_migration0.99139455
111MP0003115_abnormal_respiratory_system0.98941106
112MP0000013_abnormal_adipose_tissue0.98906799
113MP0003567_abnormal_fetal_cardiomyocyte0.98837266
114MP0002752_abnormal_somatic_nervous0.97612503
115MP0009053_abnormal_anal_canal0.96644762
116MP0006276_abnormal_autonomic_nervous0.95422436
117MP0005195_abnormal_posterior_eye0.95179990
118MP0004142_abnormal_muscle_tone0.94474471
119MP0002928_abnormal_bile_duct0.93431529
120MP0000566_synostosis0.92501095
121MP0001324_abnormal_eye_pigmentation0.89984352
122MP0002066_abnormal_motor_capabilities/c0.89584678
123MP0000026_abnormal_inner_ear0.89571488
124MP0002084_abnormal_developmental_patter0.89214695
125MP0001348_abnormal_lacrimal_gland0.89050358
126MP0000631_abnormal_neuroendocrine_gland0.88457068
127MP0004197_abnormal_fetal_growth/weight/0.88181225
128MP0002081_perinatal_lethality0.86757914
129MP0003045_fibrosis0.85977429
130MP0005394_taste/olfaction_phenotype0.85454997
131MP0005499_abnormal_olfactory_system0.85454997
132MP0000383_abnormal_hair_follicle0.85065826
133MP0003935_abnormal_craniofacial_develop0.84671299
134MP0002109_abnormal_limb_morphology0.83990149
135MP0008770_decreased_survivor_rate0.82901283
136MP0001440_abnormal_grooming_behavior0.81658944
137MP0001529_abnormal_vocalization0.81488869
138MP0009250_abnormal_appendicular_skeleto0.80647973
139MP0000733_abnormal_muscle_development0.78099284
140MP0001849_ear_inflammation0.77638928
141MP0000428_abnormal_craniofacial_morphol0.75383036
142MP0002272_abnormal_nervous_system0.75107164
143MP0001501_abnormal_sleep_pattern0.74381563
144MP0001879_abnormal_lymphatic_vessel0.74097415
145MP0002653_abnormal_ependyma_morphology0.73843878
146MP0003385_abnormal_body_wall0.71099172
147MP0000003_abnormal_adipose_tissue0.69845364
148MP0004510_myositis0.67813562
149MP0001984_abnormal_olfaction0.67371407
150MP0010769_abnormal_survival0.66149954
151MP0010770_preweaning_lethality0.65763342
152MP0002082_postnatal_lethality0.65763342
153MP0003879_abnormal_hair_cell0.65472037
154MP0002116_abnormal_craniofacial_bone0.65023473
155MP0010368_abnormal_lymphatic_system0.64962248
156MP0001177_atelectasis0.64900741
157MP0002089_abnormal_postnatal_growth/wei0.64170795
158MP0009278_abnormal_bone_marrow0.63991747
159MP0002069_abnormal_eating/drinking_beha0.63834729
160MP0002085_abnormal_embryonic_tissue0.62913914
161MP0002925_abnormal_cardiovascular_devel0.61315173
162MP0004808_abnormal_hematopoietic_stem0.61261018

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)4.27923272
2Absent/shortened dynein arms (HP:0200106)4.08642129
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.08642129
4Tubulointerstitial nephritis (HP:0001970)3.80779997
5Pancreatic fibrosis (HP:0100732)3.58321530
6Pancreatic cysts (HP:0001737)3.50877847
7Nephronophthisis (HP:0000090)3.21685745
8True hermaphroditism (HP:0010459)3.20207982
9Macroorchidism (HP:0000053)3.06615072
10Abnormal ciliary motility (HP:0012262)3.05372375
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.99739217
12Abnormal respiratory motile cilium morphology (HP:0005938)2.93961041
13Abnormal respiratory epithelium morphology (HP:0012253)2.93961041
14Abnormal respiratory motile cilium physiology (HP:0012261)2.89313970
15Abnormality of the renal medulla (HP:0100957)2.81805911
16Amyotrophic lateral sclerosis (HP:0007354)2.81021299
17Molar tooth sign on MRI (HP:0002419)2.78079867
18Abnormality of midbrain morphology (HP:0002418)2.78079867
19Supranuclear gaze palsy (HP:0000605)2.77150650
20Urinary bladder sphincter dysfunction (HP:0002839)2.73235000
21Myokymia (HP:0002411)2.70247975
22Hyperacusis (HP:0010780)2.69548069
23Papilledema (HP:0001085)2.67747432
24Abnormality of the labia minora (HP:0012880)2.67236370
25Mutism (HP:0002300)2.67172552
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.64427980
27Vertebral arch anomaly (HP:0008438)2.62156343
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.61832554
29Focal seizures (HP:0007359)2.61470185
30Pointed chin (HP:0000307)2.58831719
31Heterotopia (HP:0002282)2.58334798
32Genetic anticipation (HP:0003743)2.52429459
33Shallow orbits (HP:0000586)2.51029771
34Bony spicule pigmentary retinopathy (HP:0007737)2.48862076
35Type II lissencephaly (HP:0007260)2.48391897
36Excessive salivation (HP:0003781)2.46564639
37Drooling (HP:0002307)2.46564639
38Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.41203140
39Short 4th metacarpal (HP:0010044)2.41203140
40Urinary urgency (HP:0000012)2.40751551
41Chromsome breakage (HP:0040012)2.39618326
42Visual hallucinations (HP:0002367)2.35833985
43Medial flaring of the eyebrow (HP:0010747)2.33417185
44Abnormality of the ileum (HP:0001549)2.31034211
45Aqueductal stenosis (HP:0002410)2.30946565
46Abnormality of the lower motor neuron (HP:0002366)2.30864401
47Enlarged penis (HP:0000040)2.30150087
48Papillary thyroid carcinoma (HP:0002895)2.30009841
49Postaxial foot polydactyly (HP:0001830)2.29137615
50Elfin facies (HP:0004428)2.28733230
51Abnormality of the astrocytes (HP:0100707)2.28621779
52Astrocytoma (HP:0009592)2.28621779
53Occipital encephalocele (HP:0002085)2.27390566
54Meckel diverticulum (HP:0002245)2.26738724
55Impaired vibration sensation in the lower limbs (HP:0002166)2.26227875
56Genital tract atresia (HP:0001827)2.25757128
57Ectopic kidney (HP:0000086)2.25601152
58Ankle clonus (HP:0011448)2.24650528
59Insidious onset (HP:0003587)2.24100832
60Termporal pattern (HP:0011008)2.24100832
61Gait imbalance (HP:0002141)2.23230853
62Abnormal rod and cone electroretinograms (HP:0008323)2.22344116
63Congenital primary aphakia (HP:0007707)2.21297018
64Cystic liver disease (HP:0006706)2.19974780
65Cerebellar dysplasia (HP:0007033)2.18787940
66Vaginal atresia (HP:0000148)2.17656548
67Poor coordination (HP:0002370)2.17005864
68Abnormality of the corticospinal tract (HP:0002492)2.15946696
69Bowel diverticulosis (HP:0005222)2.15324011
70Subacute progressive viral hepatitis (HP:0006572)2.14176276
71Cerebral aneurysm (HP:0004944)2.12442466
72Inappropriate behavior (HP:0000719)2.11602239
73Aplasia/Hypoplasia of the tongue (HP:0010295)2.11430941
74Anencephaly (HP:0002323)2.11276072
75Hepatoblastoma (HP:0002884)2.10579039
76Sloping forehead (HP:0000340)2.09504243
77Sacral dimple (HP:0000960)2.08959618
78Lissencephaly (HP:0001339)2.08285673
79Oligodactyly (hands) (HP:0001180)2.07725515
80Abnormality of the renal cortex (HP:0011035)2.07676423
81Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07323099
82Sclerocornea (HP:0000647)2.05742571
83Narrow palate (HP:0000189)2.04864952
84Cortical dysplasia (HP:0002539)2.04182705
85Nephrogenic diabetes insipidus (HP:0009806)2.04109835
86Renal duplication (HP:0000075)2.03831211
87Neoplasm of the adrenal cortex (HP:0100641)2.03613525
88Rhinitis (HP:0012384)2.03335604
89Insomnia (HP:0100785)2.03104023
90Preaxial hand polydactyly (HP:0001177)2.03038402
91Abnormality of macular pigmentation (HP:0008002)2.02553361
92Postaxial hand polydactyly (HP:0001162)2.02361880
93Progressive inability to walk (HP:0002505)1.99055596
94Abnormality of the fingertips (HP:0001211)1.98841936
95Renovascular hypertension (HP:0100817)1.97121931
96Aplasia/Hypoplasia of the sternum (HP:0006714)1.96572097
97Abnormality of chromosome stability (HP:0003220)1.95559245
98Anophthalmia (HP:0000528)1.95288588
99Epileptic encephalopathy (HP:0200134)1.95163845
100Tubulointerstitial abnormality (HP:0001969)1.93857109
101Optic nerve hypoplasia (HP:0000609)1.93365108
102Chronic bronchitis (HP:0004469)1.93034093
103Progressive cerebellar ataxia (HP:0002073)1.92051051
104Attenuation of retinal blood vessels (HP:0007843)1.91948193
105Intestinal atresia (HP:0011100)1.90135408
106Megalencephaly (HP:0001355)1.88591955
107Chorioretinal atrophy (HP:0000533)1.87678134
108Absent frontal sinuses (HP:0002688)1.87149482
109Action tremor (HP:0002345)1.86801955
110Esophageal atresia (HP:0002032)1.85529462
111Dandy-Walker malformation (HP:0001305)1.84609651
112Impaired smooth pursuit (HP:0007772)1.83609594
113Postural instability (HP:0002172)1.82606418
114Tubular atrophy (HP:0000092)1.82131593
115Apathy (HP:0000741)1.82000553
116Truncal ataxia (HP:0002078)1.81900732
117Volvulus (HP:0002580)1.81625988
118Abnormality of the carotid arteries (HP:0005344)1.81624149
119Obsessive-compulsive behavior (HP:0000722)1.81392270
120Renal dysplasia (HP:0000110)1.80977964
121Patellar aplasia (HP:0006443)1.80915908
122Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80826448
123Aplasia/Hypoplasia of the fibula (HP:0006492)1.79899235
124Colon cancer (HP:0003003)1.79299203
125Gastrointestinal atresia (HP:0002589)1.78992776
126Astigmatism (HP:0000483)1.78690656
127Partial agenesis of the corpus callosum (HP:0001338)1.78495479
128Cerebral inclusion bodies (HP:0100314)1.77066740
129Abnormality of the 4th metacarpal (HP:0010012)1.77060796
130Agitation (HP:0000713)1.76143855
131Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75374898
132Atrophy/Degeneration involving motor neurons (HP:0007373)1.74195014
133Aplasia/Hypoplasia of the tibia (HP:0005772)1.73782366
134Spastic gait (HP:0002064)1.73548157
135Lower limb asymmetry (HP:0100559)1.73373301
136Abnormality of the pubic bones (HP:0003172)1.73282113
137Growth hormone deficiency (HP:0000824)1.71848371
138High anterior hairline (HP:0009890)1.71477147
139Fibular aplasia (HP:0002990)1.71401784
140Oligodactyly (HP:0012165)1.71108921
141Small intestinal stenosis (HP:0012848)1.70989905
142Duodenal stenosis (HP:0100867)1.70989905
143Truncal obesity (HP:0001956)1.70907541
144Fibular hypoplasia (HP:0003038)1.69507506
145Retinal dysplasia (HP:0007973)1.69292814
146Protruding tongue (HP:0010808)1.69215429
147Turricephaly (HP:0000262)1.68229013
148Transitional cell carcinoma of the bladder (HP:0006740)1.67759225
149Overriding aorta (HP:0002623)1.67735210
150Glioma (HP:0009733)1.67721296
151Specific learning disability (HP:0001328)1.66691268
152Congenital hepatic fibrosis (HP:0002612)1.66608246
153Gaze-evoked nystagmus (HP:0000640)1.65891995
154Hand muscle atrophy (HP:0009130)1.65571017
155Inability to walk (HP:0002540)1.64498307
156Aplasia/Hypoplasia of the patella (HP:0006498)1.64027130
157Broad-based gait (HP:0002136)1.63971505
158Thick eyebrow (HP:0000574)1.62150995
159Increased nuchal translucency (HP:0010880)1.61957970
160Hypsarrhythmia (HP:0002521)1.61404320
161Ankyloglossia (HP:0010296)1.61213058
162Abnormality of ocular smooth pursuit (HP:0000617)1.60903711
163Aplasia/Hypoplasia of the brainstem (HP:0007362)1.60864794
164Hypoplasia of the brainstem (HP:0002365)1.60864794
165Bladder neoplasm (HP:0009725)1.60566381
166Bladder carcinoma (HP:0002862)1.60566381
167Ependymoma (HP:0002888)1.60446071
168Stereotypic behavior (HP:0000733)1.59671676
169Hemiplegia (HP:0002301)1.58151214
170Diminished motivation (HP:0000745)1.57701950
171EEG with generalized epileptiform discharges (HP:0011198)1.57347529
172Broad thumb (HP:0011304)1.57326488
173Lower limb amyotrophy (HP:0007210)1.57248851
174Dysmetric saccades (HP:0000641)1.56464660
175Arterial tortuosity (HP:0005116)1.56253224
176Mitral valve prolapse (HP:0001634)1.56189671
177Focal motor seizures (HP:0011153)1.56099093
178Open mouth (HP:0000194)1.55321752
179Lymphangioma (HP:0100764)1.54542609
180Depression (HP:0000716)1.53927272
181Impaired social interactions (HP:0000735)1.53724944
182Abnormal social behavior (HP:0012433)1.53724944
183Leiomyosarcoma (HP:0100243)1.52987649
184Uterine leiomyosarcoma (HP:0002891)1.52987649
185Buphthalmos (HP:0000557)1.52908402
186Overgrowth (HP:0001548)1.52464648
187Epileptiform EEG discharges (HP:0011182)1.52381001
188Gastrointestinal carcinoma (HP:0002672)1.52244084

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.96640792
2PLK44.26166347
3MAP3K94.22691452
4STK38L2.63646146
5NTRK32.59120074
6SIK22.47387364
7WNK32.34630808
8MAP4K22.31938645
9KSR22.26964143
10LATS22.16876096
11MAP3K42.15865653
12NUAK12.06064422
13ZAK2.02020608
14KSR11.98120544
15MINK11.97671774
16PAK61.91394131
17BMPR1B1.84486503
18NEK11.83945191
19EEF2K1.82823538
20NTRK21.80138103
21SCYL21.79516899
22STK161.74145280
23TTK1.68913289
24CASK1.67737128
25CAMK1G1.64867170
26MKNK21.64429339
27BUB11.62368674
28CDC71.60309063
29MAP3K101.60254157
30DAPK21.57255208
31RET1.56781646
32SRPK11.54379223
33EPHA41.47139452
34MAPK131.47106454
35NEK21.44628922
36PKN21.44272521
37CAMKK11.42789440
38PINK11.39659970
39MAP3K131.39105477
40PRKD31.36647188
41TNIK1.36364449
42MAPK151.35829039
43BCR1.32654804
44RIPK11.29834400
45NTRK11.29028776
46SIK11.26584858
47ALK1.24900024
48PHKG21.24704646
49PHKG11.24704646
50MARK21.24659186
51FRK1.21171757
52TRIB31.20209314
53MKNK11.19342834
54PAK31.18744712
55CDK121.14276777
56MAP3K21.12797261
57WNK41.12305223
58TRIM281.10953941
59STK31.10268522
60ERBB31.10237324
61PLK31.09890394
62CSNK1G21.08271981
63SGK31.06834841
64CDK51.06223314
65CAMK1D1.03777598
66DYRK21.03029700
67TAOK11.01166567
68MAP2K71.01110948
69PNCK1.00532603
70BRSK21.00026658
71PLK20.98816384
72PDGFRA0.98779589
73INSRR0.95963573
74PLK10.95090430
75AKT30.93473152
76CHEK20.91146690
77ADRBK20.90671951
78RPS6KA20.89393906
79MAP2K40.89002196
80ACVR1B0.88166437
81SGK20.86215125
82PTK60.85876531
83MTOR0.84663887
84TYRO30.83584641
85CSNK1A1L0.83191003
86LATS10.82764813
87RAF10.81845148
88ATM0.81244391
89LMTK20.79548771
90FGFR20.79440718
91PRKCH0.78715985
92CDC42BPA0.77172077
93ATR0.77098343
94ICK0.76767998
95STK380.76274426
96FGFR30.76170016
97JAK10.75794769
98DYRK1A0.74494957
99TSSK60.70279631
100PRKCZ0.69811918
101EIF2AK30.69496991
102DAPK10.68921191
103GRK10.68491994
104CHEK10.67938594
105RPS6KA40.66658504
106STK390.65644214
107PRKAA10.63910349
108CCNB10.63403843
109TAF10.63068805
110PRKCE0.62654013
111AURKB0.61267528
112STK110.60915615
113DDR20.58985124
114BRD40.58890555
115CDK10.57612361
116WEE10.55932138
117MAPK100.55343660
118SGK10.54968483
119RIPK40.53576865
120EPHB20.52143479
121MAPK80.51633319
122CSNK1G30.51259499
123TGFBR10.51133919
124CDK80.50445864
125VRK10.49675246
126CDK20.49536828
127MAPK90.49520108
128CDK30.49501938
129SGK4940.49329341
130SGK2230.49329341
131FER0.48883539
132MAP3K70.48821749
133PDGFRB0.47204555
134PTK20.47100865
135CSNK1G10.46968107
136CAMKK20.46883737
137CSF1R0.46227922
138RPS6KA30.45881697
139CSNK1E0.45749399
140CDK140.45219891
141CDK180.44881900
142CDK150.44388919
143FYN0.43908707
144PRKCG0.43237386
145WNK10.42962882
146MAP2K10.42950294
147HIPK20.42601265
148DMPK0.42446769
149PRKDC0.42215884
150MAP2K20.40708398
151GSK3B0.39862163
152TTN0.39332892
153DYRK30.38100163
154MAPK120.37874701
155ERBB20.37028713
156CSNK1D0.34851308
157CDK11A0.34284212
158FGFR10.34201937
159BCKDK0.33915534
160CDK70.33899923
161PASK0.33548658
162ERBB40.33281631
163CSNK1A10.32711686

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.98838288
2Fanconi anemia pathway_Homo sapiens_hsa034602.69010490
3Homologous recombination_Homo sapiens_hsa034402.58362182
4Non-homologous end-joining_Homo sapiens_hsa034502.58054810
5Basal transcription factors_Homo sapiens_hsa030222.46741154
6Selenocompound metabolism_Homo sapiens_hsa004502.41544001
7RNA transport_Homo sapiens_hsa030132.25895722
8Mismatch repair_Homo sapiens_hsa034302.10711211
9Fatty acid biosynthesis_Homo sapiens_hsa000612.03400244
10Phototransduction_Homo sapiens_hsa047442.02271503
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98315547
12RNA degradation_Homo sapiens_hsa030181.84307719
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78214351
14Long-term potentiation_Homo sapiens_hsa047201.77490808
15Synaptic vesicle cycle_Homo sapiens_hsa047211.75997214
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73938050
17Circadian entrainment_Homo sapiens_hsa047131.73053397
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72306721
19Type II diabetes mellitus_Homo sapiens_hsa049301.69732464
20Butanoate metabolism_Homo sapiens_hsa006501.68446223
21Nucleotide excision repair_Homo sapiens_hsa034201.64322731
22Endometrial cancer_Homo sapiens_hsa052131.59919619
23Dopaminergic synapse_Homo sapiens_hsa047281.58506767
24Nicotine addiction_Homo sapiens_hsa050331.58224511
25Olfactory transduction_Homo sapiens_hsa047401.56808189
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.54631691
27One carbon pool by folate_Homo sapiens_hsa006701.54165940
28Glioma_Homo sapiens_hsa052141.53391314
29Amphetamine addiction_Homo sapiens_hsa050311.51953222
30Basal cell carcinoma_Homo sapiens_hsa052171.51836591
31Cholinergic synapse_Homo sapiens_hsa047251.51576303
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51464886
33Colorectal cancer_Homo sapiens_hsa052101.50634231
34mTOR signaling pathway_Homo sapiens_hsa041501.49406021
35Glutamatergic synapse_Homo sapiens_hsa047241.48816706
36Estrogen signaling pathway_Homo sapiens_hsa049151.47123546
37Spliceosome_Homo sapiens_hsa030401.46557656
38Insulin secretion_Homo sapiens_hsa049111.45026108
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.43135925
40Morphine addiction_Homo sapiens_hsa050321.42642359
41Axon guidance_Homo sapiens_hsa043601.38893761
42Cell cycle_Homo sapiens_hsa041101.36395271
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34811996
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34537385
45GABAergic synapse_Homo sapiens_hsa047271.34443268
46DNA replication_Homo sapiens_hsa030301.33609319
47GnRH signaling pathway_Homo sapiens_hsa049121.32266603
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31009327
49Cocaine addiction_Homo sapiens_hsa050301.30879508
50mRNA surveillance pathway_Homo sapiens_hsa030151.30352598
51ErbB signaling pathway_Homo sapiens_hsa040121.29137576
52Oxytocin signaling pathway_Homo sapiens_hsa049211.27413881
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27317874
54Gap junction_Homo sapiens_hsa045401.27136275
55Propanoate metabolism_Homo sapiens_hsa006401.25817566
56RNA polymerase_Homo sapiens_hsa030201.24706305
57Chronic myeloid leukemia_Homo sapiens_hsa052201.24460643
58Thyroid hormone signaling pathway_Homo sapiens_hsa049191.23850802
59Gastric acid secretion_Homo sapiens_hsa049711.23410723
60B cell receptor signaling pathway_Homo sapiens_hsa046621.22525045
61Dorso-ventral axis formation_Homo sapiens_hsa043201.21595291
62Salivary secretion_Homo sapiens_hsa049701.20336426
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20107281
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18299584
65Renin secretion_Homo sapiens_hsa049241.17733985
66Long-term depression_Homo sapiens_hsa047301.17013953
67Non-small cell lung cancer_Homo sapiens_hsa052231.16705810
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16422890
69Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14902004
70Steroid biosynthesis_Homo sapiens_hsa001001.12375613
71Pancreatic cancer_Homo sapiens_hsa052121.09934666
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.08499757
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08336316
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08148027
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06642844
76Oocyte meiosis_Homo sapiens_hsa041141.06161507
77Renal cell carcinoma_Homo sapiens_hsa052111.05892532
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05452662
79Melanogenesis_Homo sapiens_hsa049161.03573998
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03305927
81VEGF signaling pathway_Homo sapiens_hsa043701.03038531
82Nitrogen metabolism_Homo sapiens_hsa009101.02771230
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01063520
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00731367
85Base excision repair_Homo sapiens_hsa034101.00149338
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98728916
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98501525
88Choline metabolism in cancer_Homo sapiens_hsa052310.97526723
89Prolactin signaling pathway_Homo sapiens_hsa049170.96962362
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95047338
91cAMP signaling pathway_Homo sapiens_hsa040240.92224660
92MicroRNAs in cancer_Homo sapiens_hsa052060.92111792
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91589320
94Insulin signaling pathway_Homo sapiens_hsa049100.91353189
95MAPK signaling pathway_Homo sapiens_hsa040100.89105796
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.88228765
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87935683
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86914423
99Purine metabolism_Homo sapiens_hsa002300.86824485
100TGF-beta signaling pathway_Homo sapiens_hsa043500.86391381
101Serotonergic synapse_Homo sapiens_hsa047260.86120800
102ABC transporters_Homo sapiens_hsa020100.84938392
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83970919
104Adherens junction_Homo sapiens_hsa045200.81708709
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81121106
106Rap1 signaling pathway_Homo sapiens_hsa040150.80949771
107FoxO signaling pathway_Homo sapiens_hsa040680.79937594
108Wnt signaling pathway_Homo sapiens_hsa043100.79115379
109Hippo signaling pathway_Homo sapiens_hsa043900.78469794
110Taste transduction_Homo sapiens_hsa047420.78421874
111T cell receptor signaling pathway_Homo sapiens_hsa046600.78063180
112Circadian rhythm_Homo sapiens_hsa047100.77908754
113Insulin resistance_Homo sapiens_hsa049310.77581614
114Endocytosis_Homo sapiens_hsa041440.77156907
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76361268
116Regulation of autophagy_Homo sapiens_hsa041400.75412186
117Proteoglycans in cancer_Homo sapiens_hsa052050.75338103
118Linoleic acid metabolism_Homo sapiens_hsa005910.75200868
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.74868813
120Protein export_Homo sapiens_hsa030600.73675368
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72351951
122Glucagon signaling pathway_Homo sapiens_hsa049220.71731980
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70437312
124Platelet activation_Homo sapiens_hsa046110.69971463
125Lysine degradation_Homo sapiens_hsa003100.69023606
126Thyroid hormone synthesis_Homo sapiens_hsa049180.68934119
127Focal adhesion_Homo sapiens_hsa045100.68809237
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67491292
129Chemokine signaling pathway_Homo sapiens_hsa040620.66944323
130Calcium signaling pathway_Homo sapiens_hsa040200.66224898
131Alcoholism_Homo sapiens_hsa050340.66089907
132Fatty acid metabolism_Homo sapiens_hsa012120.65986321
133Prostate cancer_Homo sapiens_hsa052150.65977196
134AMPK signaling pathway_Homo sapiens_hsa041520.65065619
135Ras signaling pathway_Homo sapiens_hsa040140.64640531
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.64426042
137Dilated cardiomyopathy_Homo sapiens_hsa054140.64175562
138Pyrimidine metabolism_Homo sapiens_hsa002400.63935033
139Acute myeloid leukemia_Homo sapiens_hsa052210.62904887
140Viral myocarditis_Homo sapiens_hsa054160.62666389
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62605481
142Tight junction_Homo sapiens_hsa045300.60304745
143Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59290246
144Vascular smooth muscle contraction_Homo sapiens_hsa042700.58157976
145Hedgehog signaling pathway_Homo sapiens_hsa043400.58091549
146Notch signaling pathway_Homo sapiens_hsa043300.57484366
147Thyroid cancer_Homo sapiens_hsa052160.56510841
148Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55225345
149Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52955031
150Huntingtons disease_Homo sapiens_hsa050160.52125844
151Ether lipid metabolism_Homo sapiens_hsa005650.52012918
152Melanoma_Homo sapiens_hsa052180.50515077
153Glycerolipid metabolism_Homo sapiens_hsa005610.45641561
154Fatty acid degradation_Homo sapiens_hsa000710.45279088
155Inositol phosphate metabolism_Homo sapiens_hsa005620.44636276
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.43751914
157Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42157244
158Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40957142
159Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38212672
160Tryptophan metabolism_Homo sapiens_hsa003800.32165050

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