DHX58

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.87211341
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.87211341
3antigen processing and presentation of endogenous antigen (GO:0019883)5.74031175
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.57492647
5cellular response to type I interferon (GO:0071357)5.53847712
6type I interferon signaling pathway (GO:0060337)5.53847712
7response to type I interferon (GO:0034340)5.48184505
8positive regulation of interferon-alpha production (GO:0032727)5.25687131
9regulation of interferon-alpha production (GO:0032647)4.95767628
10negative regulation of interleukin-12 production (GO:0032695)4.72295929
11positive regulation by symbiont of host defense response (GO:0052509)4.64526663
12modulation by symbiont of host defense response (GO:0052031)4.64526663
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.64526663
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.64526663
15positive regulation by organism of defense response of other organism involved in symbiotic interact4.64526663
16modulation by symbiont of host immune response (GO:0052553)4.64526663
17response to interferon-alpha (GO:0035455)4.63112898
18immunoglobulin mediated immune response (GO:0016064)4.50873078
19neutrophil activation involved in immune response (GO:0002283)4.29113932
20response to peptidoglycan (GO:0032494)4.26957209
21positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.22562155
22regulation of T-helper 1 cell differentiation (GO:0045625)4.22558416
23regulation of vitamin D biosynthetic process (GO:0060556)4.19755063
24negative regulation of viral genome replication (GO:0045071)4.15007844
25positive regulation of gamma-delta T cell activation (GO:0046645)4.13335166
26cellular response to interferon-beta (GO:0035458)4.09064214
27response to interferon-beta (GO:0035456)4.06622371
28negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.04901366
29negative regulation of cell killing (GO:0031342)4.04901366
30T-helper 1 type immune response (GO:0042088)4.01621828
31regulation of chronic inflammatory response (GO:0002676)3.98005476
32positive regulation of antigen processing and presentation (GO:0002579)3.97669033
33regulation of interferon-beta biosynthetic process (GO:0045357)3.97631953
34interferon-gamma-mediated signaling pathway (GO:0060333)3.96600028
35defense response to protozoan (GO:0042832)3.83747785
36negative regulation of cytokine production involved in immune response (GO:0002719)3.76317960
37positive regulation of interferon-beta production (GO:0032728)3.73599940
38positive regulation of natural killer cell differentiation (GO:0032825)3.71700059
39regulation of dendritic cell antigen processing and presentation (GO:0002604)3.69752517
40regulation of activation of Janus kinase activity (GO:0010533)3.64726957
41regulation of cytokine secretion involved in immune response (GO:0002739)3.64477457
42cellular response to exogenous dsRNA (GO:0071360)3.63933002
43cellular response to virus (GO:0098586)3.56033994
44response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.55416881
45response to host immune response (GO:0052572)3.55416881
46lipopolysaccharide-mediated signaling pathway (GO:0031663)3.53821770
47detection of other organism (GO:0098543)3.52648071
48germinal center formation (GO:0002467)3.50651467
49regulation of type 2 immune response (GO:0002828)3.49202685
50B cell mediated immunity (GO:0019724)3.46660019
51regulation of type I interferon-mediated signaling pathway (GO:0060338)3.45423649
52macrophage activation involved in immune response (GO:0002281)3.43798029
53positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.43338468
54granulocyte activation (GO:0036230)3.42828195
55regulation of antigen processing and presentation (GO:0002577)3.41729623
56T cell migration (GO:0072678)3.40661447
57respiratory burst (GO:0045730)3.39944538
58detection of bacterium (GO:0016045)3.39737512
59cellular response to interferon-alpha (GO:0035457)3.39161605
60NIK/NF-kappaB signaling (GO:0038061)3.38969332
61natural killer cell mediated cytotoxicity (GO:0042267)3.38627671
62natural killer cell mediated immunity (GO:0002228)3.38627671
63neutrophil activation (GO:0042119)3.37734013
64response to protozoan (GO:0001562)3.36224592
65regulation of vitamin metabolic process (GO:0030656)3.35863557
66positive regulation of interleukin-12 production (GO:0032735)3.33221284
67regulation of gamma-delta T cell activation (GO:0046643)3.33208974
68negative regulation of T cell mediated immunity (GO:0002710)3.32672260
69regulation of alpha-beta T cell proliferation (GO:0046640)3.32524650
70* regulation of RIG-I signaling pathway (GO:0039535)3.31713198
71regulation of B cell receptor signaling pathway (GO:0050855)3.28483916
72positive regulation of alpha-beta T cell proliferation (GO:0046641)3.25699564
73negative regulation of interleukin-17 production (GO:0032700)3.25123216
74regulation of T cell tolerance induction (GO:0002664)3.24564760
75positive regulation of type 2 immune response (GO:0002830)3.24120191
76antigen processing and presentation via MHC class Ib (GO:0002475)3.23932910
77cellular response to interferon-gamma (GO:0071346)3.21110043
78positive regulation of interleukin-17 production (GO:0032740)3.17919735
79positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.16482741
80positive regulation of defense response to virus by host (GO:0002230)3.15817109
81response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.14259605
82response to host (GO:0075136)3.14259605
83response to host defenses (GO:0052200)3.14259605
84positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.11042359
85regulation of T-helper 2 cell differentiation (GO:0045628)3.08198166
86positive regulation of T-helper cell differentiation (GO:0045624)3.05926539
87regulation of interleukin-12 biosynthetic process (GO:0045075)3.05877993
88myeloid cell activation involved in immune response (GO:0002275)3.05859713
89regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.05327051
90regulation of T-helper cell differentiation (GO:0045622)3.05055458
91regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.04445388
92negative regulation of production of molecular mediator of immune response (GO:0002701)3.03172636
93lymphocyte chemotaxis (GO:0048247)3.02580494
94regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.02497572
95regulation of podosome assembly (GO:0071801)3.01961602
96myeloid dendritic cell differentiation (GO:0043011)3.01887059
97regulation of interleukin-17 production (GO:0032660)3.01537686
98response to interferon-gamma (GO:0034341)3.01119263
99regulation of defense response to virus by host (GO:0050691)3.00712450
100positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.00283510
101* defense response to virus (GO:0051607)3.00076414
102myeloid dendritic cell activation (GO:0001773)2.99050101
103negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.98115797
104negative regulation of type 2 immune response (GO:0002829)2.97454315
105positive regulation of chemokine biosynthetic process (GO:0045080)2.96653417
106detection of external biotic stimulus (GO:0098581)2.94496994
107response to muramyl dipeptide (GO:0032495)2.94042483
108positive regulation of NF-kappaB import into nucleus (GO:0042346)2.93698811
109interferon-gamma secretion (GO:0072643)2.92728410
110dendritic cell differentiation (GO:0097028)2.92331056
111positive regulation of humoral immune response (GO:0002922)2.91608590
112regulation of tolerance induction (GO:0002643)2.91543098
113superoxide anion generation (GO:0042554)2.90765369
114positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.90303806
115regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.90290018
116positive regulation of heat generation (GO:0031652)2.90086941
117detection of molecule of bacterial origin (GO:0032490)2.89904962
118positive regulation of B cell differentiation (GO:0045579)2.88311179
119regulation of chemokine biosynthetic process (GO:0045073)2.88262447
120JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.88053852
121positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.87154024
122production of molecular mediator involved in inflammatory response (GO:0002532)2.86611631
123regulation of MHC class I biosynthetic process (GO:0045343)2.86363547
124positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.83733265
125regulation of interferon-beta production (GO:0032648)2.83696177
126regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.83319390
127regulation of interferon-gamma biosynthetic process (GO:0045072)2.82974824
128negative regulation of viral process (GO:0048525)2.82554958
129cellular response to zinc ion (GO:0071294)2.82126529
130hydrogen peroxide biosynthetic process (GO:0050665)2.80697549
131regulation of T-helper 1 type immune response (GO:0002825)2.80441648
132regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.80259155
133negative regulation of myeloid cell apoptotic process (GO:0033033)2.80105285
134positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80098039
135regulation of viral genome replication (GO:0045069)2.78450127
136regulation of interleukin-8 biosynthetic process (GO:0045414)2.77355646
137negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.76961528
138regulation of B cell differentiation (GO:0045577)2.76318389
139regulation of interleukin-12 production (GO:0032655)2.75279834

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.07528121
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.63340458
3* IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.87134511
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.47474709
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.26094346
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.24252612
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.99420808
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.37955752
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.31587436
10* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.22157845
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.05261306
12STAT4_19710469_ChIP-ChIP_TH1__Mouse3.01517511
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.92458947
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.81603040
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.63259346
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.59742679
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.45344287
18SPI1_23547873_ChIP-Seq_NB4_Human2.19224034
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.18506623
20SCL_19346495_ChIP-Seq_HPC-7_Human2.09950167
21MYB_26560356_Chip-Seq_TH2_Human1.98243583
22* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.95972699
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95425508
24GATA1_22025678_ChIP-Seq_K562_Human1.90153907
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.87500810
26* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86430828
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.85972813
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83313654
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78429649
30MAF_26560356_Chip-Seq_TH1_Human1.78258650
31* MYB_26560356_Chip-Seq_TH1_Human1.74391986
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71140326
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70427968
34RUNX_20019798_ChIP-Seq_JUKART_Human1.67744347
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66204862
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.64145137
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61019674
38* PU_27001747_Chip-Seq_BMDM_Mouse1.55582412
39PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54697010
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.54354119
41VDR_24763502_ChIP-Seq_THP-1_Human1.54055492
42CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52068196
43CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48743437
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42685737
45KDM2B_26808549_Chip-Seq_DND41_Human1.42064673
46SPI1_23127762_ChIP-Seq_K562_Human1.37779740
47LXR_22292898_ChIP-Seq_THP-1_Human1.37572729
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36999423
49GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32956503
50VDR_21846776_ChIP-Seq_THP-1_Human1.32388459
51GATA3_26560356_Chip-Seq_TH2_Human1.31383291
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27256389
53PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26198825
54GATA3_27048872_Chip-Seq_THYMUS_Human1.25303202
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24760259
56CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23747086
57* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21468567
58SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17051436
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16061204
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15787757
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.15474641
62UTX_26944678_Chip-Seq_JUKART_Human1.15156186
63ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.14851499
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14439004
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12948498
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12725649
67* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10734554
68VDR_24787735_ChIP-Seq_THP-1_Human1.08021263
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.07845986
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07755572
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06806358
72GATA1_19941826_ChIP-Seq_K562_Human1.06288984
73FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.05333876
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.03085054
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02535836
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01649771
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01117341
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00934594
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97418127
80MAF_26560356_Chip-Seq_TH2_Human0.96032148
81RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94947655
82MYC_22102868_ChIP-Seq_BL_Human0.94784068
83PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94413127
84RXR_22158963_ChIP-Seq_LIVER_Mouse0.93878757
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93665948
86PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92731634
87GATA1_19941827_ChIP-Seq_MEL_Mouse0.90568034
88* BCOR_27268052_Chip-Seq_Bcells_Human0.90471805
89RACK7_27058665_Chip-Seq_MCF-7_Human0.88723583
90TCF7_22412390_ChIP-Seq_EML_Mouse0.87357424
91STAT1_20625510_ChIP-Seq_HELA_Human0.86961488
92KDM2B_26808549_Chip-Seq_JURKAT_Human0.86446043
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85528515
94ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84602789
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84564964
96TP63_17297297_ChIP-ChIP_HaCaT_Human0.83512756
97HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82784817
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81445931
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.81339495
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80376188
101EGR1_19032775_ChIP-ChIP_M12_Human0.77311130
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76816098
103CTCF_27219007_Chip-Seq_ERYTHROID_Human0.76789134
104NCOR1_26117541_ChIP-Seq_K562_Human0.76677196
105LXR_22158963_ChIP-Seq_LIVER_Mouse0.75666601
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.75238310
107GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70670449
108SPI1_20517297_ChIP-Seq_HL60_Human0.70050099
109ETS1_22383799_ChIP-Seq_G1ME_Mouse0.69881689
110BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.68141871
111* CTCF_26484167_Chip-Seq_Bcells_Mouse0.65387371
112E2F7_22180533_ChIP-Seq_HELA_Human0.64005897
113NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.63922721
114* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.62106631
115SMAD_19615063_ChIP-ChIP_OVARY_Human0.61635483
116P300_27268052_Chip-Seq_Bcells_Human0.59775234
117CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.59592669
118ELK3_25401928_ChIP-Seq_HUVEC_Human0.59100288
119GATA2_19941826_ChIP-Seq_K562_Human0.57663956
120* BCL6_27268052_Chip-Seq_Bcells_Human0.55001202
121CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.54669637

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.11688211
2* MP0009785_altered_susceptibility_to4.17631214
3MP0003436_decreased_susceptibility_to3.44418862
4MP0002148_abnormal_hypersensitivity_rea3.42925647
5MP0000685_abnormal_immune_system3.42383033
6MP0005671_abnormal_response_to3.29704055
7MP0001790_abnormal_immune_system3.27097534
8MP0005387_immune_system_phenotype3.27097534
9MP0006082_CNS_inflammation3.17739370
10MP0003724_increased_susceptibility_to3.16058092
11* MP0005025_abnormal_response_to3.15028661
12MP0005000_abnormal_immune_tolerance3.08873782
13MP0002419_abnormal_innate_immunity2.91015278
14MP0001800_abnormal_humoral_immune2.79260991
15MP0002452_abnormal_antigen_presenting2.68804943
16* MP0002723_abnormal_immune_serum2.67043285
17MP0001819_abnormal_immune_cell2.37687740
18MP0002420_abnormal_adaptive_immunity2.34050555
19MP0004510_myositis2.21361334
20MP0005058_abnormal_lysosome_morphology2.12410824
21MP0005464_abnormal_platelet_physiology2.11388561
22MP0003303_peritoneal_inflammation2.10818817
23MP0005451_abnormal_body_composition2.05354291
24MP0001845_abnormal_inflammatory_respons1.94010370
25MP0004947_skin_inflammation1.93455463
26* MP0008469_abnormal_protein_level1.90107764
27MP0001853_heart_inflammation1.88066952
28MP0010155_abnormal_intestine_physiology1.86265713
29MP0002398_abnormal_bone_marrow1.85840364
30MP0001533_abnormal_skeleton_physiology1.85184666
31MP0002405_respiratory_system_inflammati1.84845105
32MP0000716_abnormal_immune_system1.83838266
33MP0002166_altered_tumor_susceptibility1.82940567
34MP0002006_tumorigenesis1.80183715
35* MP0009764_decreased_sensitivity_to1.79665518
36MP0003763_abnormal_thymus_physiology1.73825740
37MP0003191_abnormal_cellular_cholesterol1.65650636
38MP0008004_abnormal_stomach_pH1.65571152
39MP0009333_abnormal_splenocyte_physiolog1.61723106
40MP0000689_abnormal_spleen_morphology1.52556747
41MP0005397_hematopoietic_system_phenotyp1.51582363
42MP0001545_abnormal_hematopoietic_system1.51582363
43MP0002429_abnormal_blood_cell1.50770436
44MP0003172_abnormal_lysosome_physiology1.49289187
45MP0002332_abnormal_exercise_endurance1.46167762
46MP0009840_abnormal_foam_cell1.44806415
47MP0002722_abnormal_immune_system1.40653467
48MP0000343_altered_response_to1.38205852
49MP0003448_altered_tumor_morphology1.36463793
50MP0005310_abnormal_salivary_gland1.36223483
51MP0002396_abnormal_hematopoietic_system1.31435107
52MP0004782_abnormal_surfactant_physiolog1.27302355
53MP0002138_abnormal_hepatobiliary_system1.26551178
54MP0009278_abnormal_bone_marrow1.26370972
55MP0003075_altered_response_to1.21884046
56MP0004808_abnormal_hematopoietic_stem1.19351892
57MP0003806_abnormal_nucleotide_metabolis1.18340712
58MP0000858_altered_metastatic_potential1.16381290
59MP0003300_gastrointestinal_ulcer1.16106870
60* MP0009763_increased_sensitivity_to1.12685149
61MP0006054_spinal_hemorrhage1.10558669
62MP0001873_stomach_inflammation1.08650208
63MP0002998_abnormal_bone_remodeling1.01308594
64MP0003195_calcinosis1.00977958
65MP0002933_joint_inflammation1.00595121
66MP0008260_abnormal_autophagy0.97614068
67MP0003091_abnormal_cell_migration0.95963422
68MP0004883_abnormal_blood_vessel0.92582824
69MP0003866_abnormal_defecation0.91096724
70MP0000703_abnormal_thymus_morphology0.89579367
71MP0003186_abnormal_redox_activity0.88663687
72MP0005174_abnormal_tail_pigmentation0.87997779
73MP0005166_decreased_susceptibility_to0.87983573
74MP0005390_skeleton_phenotype0.87582883
75MP0000465_gastrointestinal_hemorrhage0.87406858
76MP0005167_abnormal_blood-brain_barrier0.85847790
77MP0010307_abnormal_tumor_latency0.84414387
78MP0000490_abnormal_crypts_of0.84353418
79MP0005083_abnormal_biliary_tract0.84002687
80MP0001663_abnormal_digestive_system0.83103680
81MP0002277_abnormal_respiratory_mucosa0.80419413
82MP0001542_abnormal_bone_strength0.79454336
83MP0000569_abnormal_digit_pigmentation0.79045030
84MP0001851_eye_inflammation0.78554155
85MP0003183_abnormal_peptide_metabolism0.78181095
86MP0000604_amyloidosis0.75527108
87MP0005165_increased_susceptibility_to0.73977928
88MP0008874_decreased_physiological_sensi0.73268296
89MP0002254_reproductive_system_inflammat0.71530314
90MP0000609_abnormal_liver_physiology0.68894722
91MP0005360_urolithiasis0.68713100
92MP0005319_abnormal_enzyme/_coenzyme0.68682888
93MP0003690_abnormal_glial_cell0.68042762
94MP0000249_abnormal_blood_vessel0.67634668
95MP0001501_abnormal_sleep_pattern0.67203996
96MP0001348_abnormal_lacrimal_gland0.66078834
97MP0005023_abnormal_wound_healing0.65930660
98MP0005666_abnormal_adipose_tissue0.65676718
99MP0005164_abnormal_response_to0.65377599
100MP0005535_abnormal_body_temperature0.65250220
101MP0009765_abnormal_xenobiotic_induced0.65094666
102MP0000920_abnormal_myelination0.62978639
103MP0002139_abnormal_hepatobiliary_system0.61570093
104MP0002136_abnormal_kidney_physiology0.61127505
105MP0000015_abnormal_ear_pigmentation0.58397493
106MP0003045_fibrosis0.58073145
107MP0003656_abnormal_erythrocyte_physiolo0.57890020
108MP0003453_abnormal_keratinocyte_physiol0.57415307
109MP0005584_abnormal_enzyme/coenzyme_acti0.57181808
110MP0003828_pulmonary_edema0.56876657
111MP0000598_abnormal_liver_morphology0.55036861
112MP0003566_abnormal_cell_adhesion0.54831549
113MP0002019_abnormal_tumor_incidence0.54681887
114MP0003795_abnormal_bone_structure0.54175469
115MP0002693_abnormal_pancreas_physiology0.53877196
116MP0005076_abnormal_cell_differentiation0.53849949
117MP0000371_diluted_coat_color0.53041391
118MP0001764_abnormal_homeostasis0.52609473

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.03943777
2Eczematoid dermatitis (HP:0000976)5.82182143
3Recurrent bacterial skin infections (HP:0005406)5.79317697
4Elevated erythrocyte sedimentation rate (HP:0003565)5.11811897
5Recurrent gram-negative bacterial infections (HP:0005420)4.92464543
6Autoimmune thrombocytopenia (HP:0001973)4.79349765
7Chronic otitis media (HP:0000389)4.78192504
8Myositis (HP:0100614)4.68200063
9Abnormality of liposaccharide metabolism (HP:0010968)4.65677145
10Mediastinal lymphadenopathy (HP:0100721)4.09472451
11Abnormality of macrophages (HP:0004311)4.06180268
12Orchitis (HP:0100796)4.04856589
13Recurrent fungal infections (HP:0002841)3.99098952
14Recurrent skin infections (HP:0001581)3.91911775
15Increased IgM level (HP:0003496)3.89691866
16Recurrent viral infections (HP:0004429)3.89524597
17Vasculitis (HP:0002633)3.87335908
18Nasal polyposis (HP:0100582)3.67357329
19Optic neuritis (HP:0100653)3.65861930
20Retrobulbar optic neuritis (HP:0100654)3.65861930
21Basal ganglia calcification (HP:0002135)3.65602211
22Systemic lupus erythematosus (HP:0002725)3.65124078
23Recurrent bronchitis (HP:0002837)3.38403995
24Abnormality of the nasal mucosa (HP:0000433)3.33551857
25Increased neuronal autofluorescent lipopigment (HP:0002074)3.30661847
26Gingivitis (HP:0000230)3.29042602
27Increased cerebral lipofuscin (HP:0011813)3.28174885
28Hypergammaglobulinemia (HP:0010702)3.22398030
29Vacuolated lymphocytes (HP:0001922)3.20656299
30Chronic mucocutaneous candidiasis (HP:0002728)3.16521328
31Recurrent cutaneous fungal infections (HP:0011370)3.16521328
32Gastrointestinal infarctions (HP:0005244)3.09606225
33Periodontitis (HP:0000704)2.99583159
34Stomatitis (HP:0010280)2.99206113
35Obstructive lung disease (HP:0006536)2.99136377
36Chronic obstructive pulmonary disease (HP:0006510)2.99136377
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.96386019
38Interstitial pulmonary disease (HP:0006530)2.94415697
39Gingival bleeding (HP:0000225)2.92022956
40Meningitis (HP:0001287)2.90856574
41Pustule (HP:0200039)2.88317988
42Disinhibition (HP:0000734)2.87506282
43Pulmonary infiltrates (HP:0002113)2.86844468
44Cellulitis (HP:0100658)2.83808946
45Loss of speech (HP:0002371)2.74703421
46Abnormality of T cell physiology (HP:0011840)2.73516355
47Petechiae (HP:0000967)2.69954561
48Arterial thrombosis (HP:0004420)2.69550944
49Chronic sinusitis (HP:0011109)2.68705470
50Hemoptysis (HP:0002105)2.62013187
51Abnormality of T cells (HP:0002843)2.60525685
52Autoimmune hemolytic anemia (HP:0001890)2.59497289
53Thrombocytosis (HP:0001894)2.58554796
54Abnormality of T cell number (HP:0011839)2.58538024
55Increased serum ferritin (HP:0003281)2.57427091
56Abnormality of mucopolysaccharide metabolism (HP:0011020)2.55003295
57Abnormality of polysaccharide metabolism (HP:0011012)2.55003295
58Abnormality of glycosaminoglycan metabolism (HP:0004371)2.55003295
59Leukocytosis (HP:0001974)2.52522831
60Tetraparesis (HP:0002273)2.52499650
61Amyloidosis (HP:0011034)2.46592268
62Abnormality of the pleura (HP:0002103)2.46147364
63Eosinophilia (HP:0001880)2.45336287
64Pulmonary embolism (HP:0002204)2.44939855
65Epistaxis (HP:0000421)2.44203878
66Recurrent pneumonia (HP:0006532)2.43795849
67Urinary glycosaminoglycan excretion (HP:0003541)2.42684045
68Mucopolysacchariduria (HP:0008155)2.42684045
69Joint swelling (HP:0001386)2.41848792
70Panhypogammaglobulinemia (HP:0003139)2.41631250
71Urticaria (HP:0001025)2.39763656
72Joint hemorrhage (HP:0005261)2.37862037
73Purpura (HP:0000979)2.35984906
74Mutism (HP:0002300)2.34760402
75T lymphocytopenia (HP:0005403)2.33926200
76Prostate neoplasm (HP:0100787)2.33478831
77Keratoconjunctivitis sicca (HP:0001097)2.32097524
78Polyneuropathy (HP:0001271)2.31839380
79Hematochezia (HP:0002573)2.29430788
80Osteomyelitis (HP:0002754)2.29297289
81Anorexia (HP:0002039)2.28914238
82Recurrent lower respiratory tract infections (HP:0002783)2.28798367
83IgG deficiency (HP:0004315)2.28456344
84Nuclear cataract (HP:0100018)2.27532494
85IgM deficiency (HP:0002850)2.26432173
86Increased IgE level (HP:0003212)2.24508264
87Abnormality of the pericardium (HP:0001697)2.23571308
88Prolonged bleeding time (HP:0003010)2.22840860
89Chronic diarrhea (HP:0002028)2.21912479
90Colitis (HP:0002583)2.21833351
91Parakeratosis (HP:0001036)2.21369708
92Abnormality of the prostate (HP:0008775)2.21355269
93Episodic fever (HP:0001954)2.21109999
94Inflammation of the large intestine (HP:0002037)2.20867325
95Spontaneous hematomas (HP:0007420)2.19746782
96Acne (HP:0001061)2.17830751
97Agammaglobulinemia (HP:0004432)2.17532763
98Keratoconjunctivitis (HP:0001096)2.16986337
99Progressive neurologic deterioration (HP:0002344)2.16429542
100Myocardial infarction (HP:0001658)2.16102820
101Abnormality of iron homeostasis (HP:0011031)2.16010999
102Thyroiditis (HP:0100646)2.14299799
103Vertigo (HP:0002321)2.12635066
104Gastrointestinal inflammation (HP:0004386)2.11234009
105Granulocytopenia (HP:0001913)2.10812988
106Poor head control (HP:0002421)2.10360565
107Glomerulopathy (HP:0100820)2.09946658
108Hepatosplenomegaly (HP:0001433)2.09769103
109Abnormality of eosinophils (HP:0001879)2.09628278
110Complement deficiency (HP:0004431)2.09098447
111Encephalitis (HP:0002383)2.08931856
112Gangrene (HP:0100758)2.08136798
113Abnormality of the endocardium (HP:0004306)2.05749342
114Malnutrition (HP:0004395)2.05669439
115Abnormality of cells of the lymphoid lineage (HP:0012140)2.05099040
116Chest pain (HP:0100749)2.04737617
117Neurofibrillary tangles (HP:0002185)2.04570154
118Glomerulonephritis (HP:0000099)2.04272711
119Lymphopenia (HP:0001888)2.03807080
120Arthralgia (HP:0002829)2.03168150
121Skin ulcer (HP:0200042)2.03058380
122Gastrointestinal stroma tumor (HP:0100723)2.03039573
123Thick nail (HP:0001805)2.03023631
124Dysostosis multiplex (HP:0000943)2.01560788
125Porencephaly (HP:0002132)2.01316528
126Abnormality of glycolipid metabolism (HP:0010969)1.99910167
127Abnormality of glycosphingolipid metabolism (HP:0004343)1.99910167
128Memory impairment (HP:0002354)1.98236251
129Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.96942687

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.27067588
2TYK24.01645056
3TBK13.58604005
4MAP4K13.53230741
5IRAK43.46955633
6KIT3.29001285
7IKBKE3.25166065
8JAK33.14076495
9IRAK33.09281050
10BLK3.06707427
11PRPF4B2.73470436
12ERN12.59636717
13JAK12.51812563
14TXK2.51509792
15IKBKB2.25074004
16TAOK22.20526384
17RIPK42.14930246
18FGFR42.09406677
19ZAP701.82412991
20CSF1R1.81346181
21SYK1.76320374
22BTK1.74368142
23TAOK11.73455428
24TEC1.71080720
25FLT31.70795281
26PIM21.58823466
27DDR21.56396771
28PBK1.56176954
29MAP3K131.55067042
30CSK1.44956490
31TAOK31.40075243
32IRAK11.38223184
33CHUK1.34602393
34NME21.33822269
35MOS1.32643679
36HCK1.32430314
37CDC42BPA1.31498524
38LCK1.25543275
39FGFR31.24134031
40LYN1.20457193
41ADRBK21.20132139
42EPHA31.16507458
43FES1.14662758
44EPHB11.12804205
45NEK91.10456179
46ITK1.10202259
47MAP3K11.04440915
48RPS6KA41.01679632
49JAK21.01615584
50TRIB31.00959182
51MATK0.97902071
52MAP3K30.95258732
53PIM10.93304612
54EIF2AK20.92556022
55HIPK20.86937456
56IRAK20.83678364
57STK100.81794583
58TGFBR20.81296587
59NLK0.78042248
60MAP2K30.76608421
61TRPM70.75830127
62TESK20.75092313
63STK40.73144152
64MST40.69285741
65SIK10.68761931
66BMPR20.64752488
67MAPK70.61133191
68BMX0.59742402
69LRRK20.58957753
70PRKCD0.55932085
71SIK30.53756749
72PRKCQ0.52160433
73ABL20.51744531
74ABL10.51505259
75YES10.51364207
76MARK20.49802011
77GRK60.49139048
78KDR0.48693317
79TYRO30.48045468
80PDPK10.47030617
81MAP3K50.44648515
82MAPK110.44558073
83PRKD20.43667330
84FGR0.43375082
85PTK60.42056219
86MARK30.41947366
87EGFR0.39111859
88CLK10.37739168
89PIK3CG0.36992780
90PKN20.36906714
91SMG10.35916726
92CAMKK20.35482668
93FYN0.34113262
94ICK0.33581652
95RPS6KA60.33103950
96IGF1R0.31240473
97MAPKAPK20.30973969
98DYRK1B0.30659151
99MAP3K100.30442150
100PKN10.30426056
101KSR20.28517611
102DAPK20.26463577
103MAPK40.25893338
104PRKG20.25808854
105RPS6KA50.24673595
106EIF2AK30.24022426
107TESK10.23953033
108TGFBR10.23412146
109MAP3K110.23328090
110MAP2K60.22818932
111PDK10.22636133
112CDK40.22338523
113ATR0.22076401
114ARAF0.22022661
115MAPK30.21861234
116GRK70.21021607
117STK30.20766888
118TNK20.20184260
119RIPK10.19470388
120RPS6KC10.18787532
121RPS6KL10.18787532
122ERBB30.18246941
123SIK20.17091169
124MST1R0.16908808
125CDK60.16546457
126RPS6KA10.15945508

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.44610376
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.28298174
3Graft-versus-host disease_Homo sapiens_hsa053323.16311141
4Leishmaniasis_Homo sapiens_hsa051403.14498640
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.85441200
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.83380978
7Staphylococcus aureus infection_Homo sapiens_hsa051502.80799958
8Measles_Homo sapiens_hsa051622.72991712
9* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.72269731
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.66922135
11Primary immunodeficiency_Homo sapiens_hsa053402.28509397
12Legionellosis_Homo sapiens_hsa051342.27634808
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24245348
14Influenza A_Homo sapiens_hsa051642.20057799
15Herpes simplex infection_Homo sapiens_hsa051682.15980019
16NOD-like receptor signaling pathway_Homo sapiens_hsa046212.15319679
17Pertussis_Homo sapiens_hsa051332.13552842
18Osteoclast differentiation_Homo sapiens_hsa043802.08207331
19Type I diabetes mellitus_Homo sapiens_hsa049402.07852091
20Antigen processing and presentation_Homo sapiens_hsa046121.95555616
21Malaria_Homo sapiens_hsa051441.95451663
22TNF signaling pathway_Homo sapiens_hsa046681.82089845
23Tuberculosis_Homo sapiens_hsa051521.73151270
24African trypanosomiasis_Homo sapiens_hsa051431.67375089
25Autoimmune thyroid disease_Homo sapiens_hsa053201.64470142
26Asthma_Homo sapiens_hsa053101.61741806
27B cell receptor signaling pathway_Homo sapiens_hsa046621.61629932
28Toxoplasmosis_Homo sapiens_hsa051451.57945211
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.57546615
30Hematopoietic cell lineage_Homo sapiens_hsa046401.54622830
31Rheumatoid arthritis_Homo sapiens_hsa053231.51870370
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47235508
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.43208166
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.37766778
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27752302
36Apoptosis_Homo sapiens_hsa042101.24488627
37Hepatitis C_Homo sapiens_hsa051601.23494000
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.20331535
39Lysosome_Homo sapiens_hsa041421.19198803
40Salmonella infection_Homo sapiens_hsa051321.18734584
41Chemokine signaling pathway_Homo sapiens_hsa040621.18039748
42Caffeine metabolism_Homo sapiens_hsa002321.17515039
43Hepatitis B_Homo sapiens_hsa051611.11850802
44Viral myocarditis_Homo sapiens_hsa054161.11537388
45Other glycan degradation_Homo sapiens_hsa005111.04917809
46Shigellosis_Homo sapiens_hsa051311.00190969
47Phagosome_Homo sapiens_hsa041450.99040754
48Complement and coagulation cascades_Homo sapiens_hsa046100.94428073
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93865513
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86666530
51T cell receptor signaling pathway_Homo sapiens_hsa046600.82683816
52ABC transporters_Homo sapiens_hsa020100.71731049
53Acute myeloid leukemia_Homo sapiens_hsa052210.70486346
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68561952
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67202384
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66585360
57VEGF signaling pathway_Homo sapiens_hsa043700.64348992
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62320851
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62051510
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.61718957
61Bladder cancer_Homo sapiens_hsa052190.57603402
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57245807
63Prolactin signaling pathway_Homo sapiens_hsa049170.56580692
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56249530
65Epstein-Barr virus infection_Homo sapiens_hsa051690.54752711
66Amoebiasis_Homo sapiens_hsa051460.52542467
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51648333
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50320967
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49082167
70Type II diabetes mellitus_Homo sapiens_hsa049300.48962377
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47283044
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.46885003
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.46574790
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.46078700
75Viral carcinogenesis_Homo sapiens_hsa052030.44916143
76Platelet activation_Homo sapiens_hsa046110.44003687
77Base excision repair_Homo sapiens_hsa034100.42082382
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40911782
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40619119
80Prion diseases_Homo sapiens_hsa050200.40233913
81Proteasome_Homo sapiens_hsa030500.36026828
82Sphingolipid metabolism_Homo sapiens_hsa006000.35237914
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.34734179
84Systemic lupus erythematosus_Homo sapiens_hsa053220.33270593
85Endocytosis_Homo sapiens_hsa041440.31862584
86FoxO signaling pathway_Homo sapiens_hsa040680.31272607
87Chronic myeloid leukemia_Homo sapiens_hsa052200.30258422
88HTLV-I infection_Homo sapiens_hsa051660.30034925
89Small cell lung cancer_Homo sapiens_hsa052220.29807274
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25674870
91Non-small cell lung cancer_Homo sapiens_hsa052230.25380688
92Notch signaling pathway_Homo sapiens_hsa043300.24878668
93Dorso-ventral axis formation_Homo sapiens_hsa043200.24206518
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23203652
95One carbon pool by folate_Homo sapiens_hsa006700.22920579
96Peroxisome_Homo sapiens_hsa041460.22367961
97MAPK signaling pathway_Homo sapiens_hsa040100.22343871
98Pancreatic cancer_Homo sapiens_hsa052120.22120082
99Renal cell carcinoma_Homo sapiens_hsa052110.22050310
100Pentose phosphate pathway_Homo sapiens_hsa000300.22011673
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.21899935
102Insulin resistance_Homo sapiens_hsa049310.21692490
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21516849
104mTOR signaling pathway_Homo sapiens_hsa041500.20129292
105p53 signaling pathway_Homo sapiens_hsa041150.19049015
106Histidine metabolism_Homo sapiens_hsa003400.18347733
107HIF-1 signaling pathway_Homo sapiens_hsa040660.16464632
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16123422
109DNA replication_Homo sapiens_hsa030300.15359383
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.14076048
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.13938111
112Collecting duct acid secretion_Homo sapiens_hsa049660.12516325
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.11534215
114Galactose metabolism_Homo sapiens_hsa000520.10743896
115GnRH signaling pathway_Homo sapiens_hsa049120.10460264
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.09788450
117Vitamin digestion and absorption_Homo sapiens_hsa049770.09733435
118Prostate cancer_Homo sapiens_hsa052150.09720354
119Arginine biosynthesis_Homo sapiens_hsa002200.09681891
120Folate biosynthesis_Homo sapiens_hsa007900.09588701
121Pyrimidine metabolism_Homo sapiens_hsa002400.08913506

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