DHX8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may be required for the replication of human immunodeficiency virus type 1 (HIV-1). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1production of molecular mediator involved in inflammatory response (GO:0002532)6.77834985
2nuclear pore organization (GO:0006999)5.18880184
3nuclear pore complex assembly (GO:0051292)5.07136397
4negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.82945651
5negative regulation of translation, ncRNA-mediated (GO:0040033)4.82945651
6regulation of translation, ncRNA-mediated (GO:0045974)4.82945651
7protein localization to kinetochore (GO:0034501)4.61110383
8mitotic nuclear envelope disassembly (GO:0007077)4.34405468
9DNA unwinding involved in DNA replication (GO:0006268)4.33715674
10pre-miRNA processing (GO:0031054)4.11302299
11nuclear envelope disassembly (GO:0051081)4.08616701
12membrane disassembly (GO:0030397)4.08616701
13mitotic metaphase plate congression (GO:0007080)4.05469214
14IMP biosynthetic process (GO:0006188)4.04148703
15protein localization to chromosome, centromeric region (GO:0071459)4.02885950
16DNA replication-dependent nucleosome assembly (GO:0006335)3.99318319
17DNA replication-dependent nucleosome organization (GO:0034723)3.99318319
18negative regulation of histone methylation (GO:0031061)3.94509108
19regulation of spindle organization (GO:0090224)3.93009411
20pore complex assembly (GO:0046931)3.86520042
21DNA replication initiation (GO:0006270)3.85686363
22regulation of histone H3-K9 methylation (GO:0051570)3.84059090
23folic acid-containing compound biosynthetic process (GO:0009396)3.82942283
24histone H3-K36 demethylation (GO:0070544)3.76828991
25nucleobase biosynthetic process (GO:0046112)3.76653322
26microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.74954038
27mitotic sister chromatid cohesion (GO:0007064)3.64445502
28DNA duplex unwinding (GO:0032508)3.63055604
29mitotic chromosome condensation (GO:0007076)3.62032605
30regulation of hippo signaling (GO:0035330)3.61757738
31DNA geometric change (GO:0032392)3.61046126
32metaphase plate congression (GO:0051310)3.60768179
33DNA strand elongation involved in DNA replication (GO:0006271)3.60027398
34mitotic sister chromatid segregation (GO:0000070)3.59673100
35purine nucleobase biosynthetic process (GO:0009113)3.52502321
36regulation of posttranscriptional gene silencing (GO:0060147)3.52035596
37regulation of gene silencing by miRNA (GO:0060964)3.52035596
38regulation of gene silencing by RNA (GO:0060966)3.52035596
39sister chromatid segregation (GO:0000819)3.48850595
40spliceosomal tri-snRNP complex assembly (GO:0000244)3.47560199
41IMP metabolic process (GO:0046040)3.43927419
42regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.42973065
43positive regulation of chromosome segregation (GO:0051984)3.42877621
44DNA strand elongation (GO:0022616)3.41483299
45heterochromatin organization (GO:0070828)3.41003403
46regulation of translation in response to stress (GO:0043555)3.34772573
47regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.32338202
48DNA replication checkpoint (GO:0000076)3.30395140
49regulation of centriole replication (GO:0046599)3.27787847
50regulation of mitotic spindle organization (GO:0060236)3.26188893
51ribosome biogenesis (GO:0042254)3.23485019
52nuclear envelope organization (GO:0006998)3.23319023
53establishment of chromosome localization (GO:0051303)3.22038050
54regulation of centrosome cycle (GO:0046605)3.19881976
55ribosome assembly (GO:0042255)3.17990884
56formation of translation preinitiation complex (GO:0001731)3.17937472
57protein localization to chromosome (GO:0034502)3.17655733
58regulation of RNA export from nucleus (GO:0046831)3.17001081
59phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.16474844
60dosage compensation (GO:0007549)3.15076322
61kinetochore organization (GO:0051383)3.14330828
62chromatin assembly or disassembly (GO:0006333)3.13554625
63chromatin assembly (GO:0031497)3.13181578
64telomere maintenance via semi-conservative replication (GO:0032201)3.12532175
65positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.12523863
66positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.12523863
67positive regulation of mitotic sister chromatid separation (GO:1901970)3.12523863
68protein K11-linked deubiquitination (GO:0035871)3.12459756
69histone mRNA catabolic process (GO:0071044)3.11558974
70attachment of spindle microtubules to kinetochore (GO:0008608)3.11005524
71DNA replication-independent nucleosome organization (GO:0034724)3.09473491
72DNA replication-independent nucleosome assembly (GO:0006336)3.09473491
73regulation of sister chromatid cohesion (GO:0007063)3.08987346
74paraxial mesoderm development (GO:0048339)3.06652197
75regulation of chromosome segregation (GO:0051983)3.04908418
76hepatocyte apoptotic process (GO:0097284)3.04226576
77regulation of helicase activity (GO:0051095)3.03985087
78negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.03316408
79monoubiquitinated protein deubiquitination (GO:0035520)3.03245608
80histone H2A monoubiquitination (GO:0035518)3.02104281
81microtubule anchoring (GO:0034453)3.01527074
82regulation of translational termination (GO:0006449)3.00914316
83regulation of translational fidelity (GO:0006450)3.00824631
84somatic hypermutation of immunoglobulin genes (GO:0016446)2.96490077
85somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96490077
86DNA conformation change (GO:0071103)2.95878907
87positive regulation of gamma-delta T cell activation (GO:0046645)2.95774912
88entrainment of circadian clock by photoperiod (GO:0043153)2.93505349
89cytoplasmic mRNA processing body assembly (GO:0033962)2.93421320
90mRNA transport (GO:0051028)2.92307434
91ER overload response (GO:0006983)2.90947654
92protein K6-linked ubiquitination (GO:0085020)2.89245816
93positive regulation of macroautophagy (GO:0016239)2.89097406
94negative regulation of chromosome segregation (GO:0051985)2.88884879
95ATP-dependent chromatin remodeling (GO:0043044)2.86834497
96maturation of SSU-rRNA (GO:0030490)2.85739141
97histone H3-K9 modification (GO:0061647)2.85647425
98regulation of mitotic metaphase/anaphase transition (GO:0030071)2.85242100
99nerve growth factor signaling pathway (GO:0038180)2.84739148
100mitotic recombination (GO:0006312)2.84276127
101kinetochore assembly (GO:0051382)2.83642827
102negative regulation of mitotic sister chromatid separation (GO:2000816)2.81838648
103negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81838648
104negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81838648
105negative regulation of sister chromatid segregation (GO:0033046)2.81838648
106telomere maintenance via recombination (GO:0000722)2.81088829
107regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.77630531
108chromatin remodeling at centromere (GO:0031055)2.76219380
109gene silencing by RNA (GO:0031047)2.75995367
110telomere maintenance via telomere lengthening (GO:0010833)2.75901156
111spindle checkpoint (GO:0031577)2.74242046
112histone H3-K9 methylation (GO:0051567)2.73469740
113necroptotic process (GO:0070266)2.73394053
114translesion synthesis (GO:0019985)2.73273052
115chromosome segregation (GO:0007059)2.72402954
116negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.72088484
117snRNA processing (GO:0016180)2.71779055
118regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.71554325
119* mRNA splicing, via spliceosome (GO:0000398)2.71254013
120* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.71254013
121* RNA splicing, via transesterification reactions (GO:0000375)2.70895952
122regulation of telomere maintenance via telomerase (GO:0032210)2.70766753
123regulation of DNA endoreduplication (GO:0032875)2.69839421
124macrophage activation involved in immune response (GO:0002281)2.69410498
125cellular response to ethanol (GO:0071361)2.64844939
126positive regulation of developmental pigmentation (GO:0048087)2.58917839
127interkinetic nuclear migration (GO:0022027)2.51244663
128regulation of nucleobase-containing compound transport (GO:0032239)2.50064923
129neural tube formation (GO:0001841)2.48541031
130modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.48390949
131positive regulation by organism of defense response of other organism involved in symbiotic interact2.48390949
132modulation by symbiont of host immune response (GO:0052553)2.48390949
133positive regulation by symbiont of host defense response (GO:0052509)2.48390949
134modulation by symbiont of host defense response (GO:0052031)2.48390949
135modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.48390949
136sister chromatid cohesion (GO:0007062)2.44675912
137positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.43148279
138protein K48-linked deubiquitination (GO:0071108)2.42372064
139RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.39905857
140regulation of B cell receptor signaling pathway (GO:0050855)2.39815345
141negative regulation of interleukin-12 production (GO:0032695)2.38429464
142nucleus organization (GO:0006997)2.36336889
143CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.35270982
144T-helper cell differentiation (GO:0042093)2.35270982
145antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.33588044
146histone lysine demethylation (GO:0070076)2.33055265
147antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.32548264
148embryonic process involved in female pregnancy (GO:0060136)2.31149518
149regulation of gamma-delta T cell activation (GO:0046643)2.31027654
150peptidyl-lysine trimethylation (GO:0018023)2.30358713
151histone H3-K4 trimethylation (GO:0080182)2.30063203
152histone demethylation (GO:0016577)2.29688182
153B cell homeostasis (GO:0001782)2.29535470
154entrainment of circadian clock (GO:0009649)2.27006900
155negative regulation of histone acetylation (GO:0035067)2.26789581
156necrotic cell death (GO:0070265)2.25694009
157negative regulation of viral release from host cell (GO:1902187)2.25100838
158negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.21377450
159negative regulation of cell killing (GO:0031342)2.21377450
160negative regulation of B cell proliferation (GO:0030889)2.21021605
161sphingosine metabolic process (GO:0006670)2.20887224
162positive regulation of interferon-beta production (GO:0032728)2.20682350
163protein dealkylation (GO:0008214)2.20495314
164protein demethylation (GO:0006482)2.20495314
165histone H4-K16 acetylation (GO:0043984)2.18317391
166response to muramyl dipeptide (GO:0032495)2.18080220
167response to nerve growth factor (GO:1990089)2.18069611
168cellular response to nerve growth factor stimulus (GO:1990090)2.18069611
169positive regulation of response to nutrient levels (GO:0032109)2.17473694
170positive regulation of response to extracellular stimulus (GO:0032106)2.17473694
171negative regulation of cAMP-mediated signaling (GO:0043951)2.16749086

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.48551683
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.27159202
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.72774632
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.56919083
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.47666477
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.42608033
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.26787045
8* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.09996634
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.95520725
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.90355017
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75350365
12MYC_22102868_ChIP-Seq_BL_Human2.58343827
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.52626760
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.43899899
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.43332422
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38745065
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.18630788
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17414182
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.17362841
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.10476243
21* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.04723568
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.01916359
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00781073
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.99668402
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90024069
26XRN2_22483619_ChIP-Seq_HELA_Human1.89582485
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.88945750
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88917593
29CIITA_25753668_ChIP-Seq_RAJI_Human1.86404378
30* EST1_17652178_ChIP-ChIP_JURKAT_Human1.84382038
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.84200249
32AR_21909140_ChIP-Seq_LNCAP_Human1.82875817
33SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.82375170
34* ETS1_20019798_ChIP-Seq_JURKAT_Human1.80955774
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80721258
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77303282
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.74803324
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73842237
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.71767142
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68858757
41* VDR_23849224_ChIP-Seq_CD4+_Human1.68381270
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.68256221
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.67955916
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66020328
45SCL_19346495_ChIP-Seq_HPC-7_Human1.63443804
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.63157492
47IRF8_27001747_Chip-Seq_BMDM_Mouse1.59623376
48GATA1_22025678_ChIP-Seq_K562_Human1.59604965
49* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.57637554
50NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.57546784
51KDM5A_27292631_Chip-Seq_BREAST_Human1.57469233
52KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.56080461
53* FOXP3_21729870_ChIP-Seq_TREG_Human1.55238588
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54725163
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54332606
56PKCTHETA_26484144_Chip-Seq_BREAST_Human1.53848307
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52931077
58RUNX_20019798_ChIP-Seq_JUKART_Human1.48783656
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45491967
60* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44163530
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43666494
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43550098
63* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.42233045
64BRD4_25478319_ChIP-Seq_HGPS_Human1.41086305
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39937124
66* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38558376
67VDR_21846776_ChIP-Seq_THP-1_Human1.38196321
68* GABP_19822575_ChIP-Seq_HepG2_Human1.38004800
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37477756
70PU_27001747_Chip-Seq_BMDM_Mouse1.37128036
71SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35819995
72SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35819995
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33709565
74* GABP_17652178_ChIP-ChIP_JURKAT_Human1.33163623
75TTF2_22483619_ChIP-Seq_HELA_Human1.32965716
76ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30840173
77BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29963519
78TFEB_21752829_ChIP-Seq_HELA_Human1.28956862
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28606200
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27041233
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23911611
82* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23274085
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23252264
84FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22188308
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21477531
86CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.20807947
87* SPI1_23127762_ChIP-Seq_K562_Human1.19795594
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19476818
89DCP1A_22483619_ChIP-Seq_HELA_Human1.18249079
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16316866
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15568493
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15417017
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15416950
94* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15258862
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.14164300
96* ELK1_19687146_ChIP-ChIP_HELA_Human1.13488117
97* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11450735
98NANOG_21062744_ChIP-ChIP_HESCs_Human1.10234164
99FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09889477
100KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09888797
101KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09888797
102KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09888797
103* GATA3_26560356_Chip-Seq_TH2_Human1.09727013
104POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08767769
105TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07867485
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07259642
107GATA3_27048872_Chip-Seq_THYMUS_Human1.06645168
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06437023
109FOXO3_23340844_ChIP-Seq_DLD1_Human1.05865758
110TCF7_22412390_ChIP-Seq_EML_Mouse1.05177624
111* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05094388
112UTX_26944678_Chip-Seq_JUKART_Human1.03859624
113ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03129885
114VDR_24787735_ChIP-Seq_THP-1_Human1.03125434
115NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02211156
116STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01618030
117* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00802999
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00201579
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00112479
120PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99727116
121FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99135172
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99018632
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98106427
124SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97916104
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.97569744
126VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97539484
127SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96463929
128YY1_21170310_ChIP-Seq_MESCs_Mouse0.96291197
129RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95737392
130ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95223374
131* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.94488517
132GATA2_21666600_ChIP-Seq_HMVEC_Human0.94068568
133SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93991630
134CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93679521
135SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93235407
136CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92539850
137MAF_26560356_Chip-Seq_TH1_Human0.92113345
138ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89915800
139KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89702070
140GATA6_25053715_ChIP-Seq_YYC3_Human0.89232142
141MYB_26560356_Chip-Seq_TH1_Human0.89172049
142TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88797281
143DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88169259
144FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87635725
145RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87367003
146FLI1_27457419_Chip-Seq_LIVER_Mouse0.86745636
147FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86707909
148MYB_26560356_Chip-Seq_TH2_Human0.85979255
149ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85927479
150* SPI1_23547873_ChIP-Seq_NB4_Human0.85926627
151KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85923550
152KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85326676
153CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.85001324
154VDR_24763502_ChIP-Seq_THP-1_Human0.84693438
155PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82555043
156TP53_16413492_ChIP-PET_HCT116_Human0.80295728
157CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79968723
158MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.79865778

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology4.38339315
2MP0003693_abnormal_embryo_hatching4.20814828
3MP0010094_abnormal_chromosome_stability4.04774160
4MP0003077_abnormal_cell_cycle3.70942405
5MP0004957_abnormal_blastocyst_morpholog3.45692044
6MP0008057_abnormal_DNA_replication3.42611449
7MP0002254_reproductive_system_inflammat3.24985038
8MP0008058_abnormal_DNA_repair2.76372752
9MP0003828_pulmonary_edema2.74855542
10MP0010307_abnormal_tumor_latency2.74108151
11MP0008007_abnormal_cellular_replicative2.68792987
12MP0010352_gastrointestinal_tract_polyps2.52426844
13MP0001730_embryonic_growth_arrest2.47537063
14MP0003300_gastrointestinal_ulcer2.36359406
15MP0000350_abnormal_cell_proliferation2.23307255
16MP0005076_abnormal_cell_differentiation2.21857927
17MP0008877_abnormal_DNA_methylation2.21813899
18MP0004381_abnormal_hair_follicle2.15692830
19MP0003950_abnormal_plasma_membrane2.15366349
20MP0002009_preneoplasia2.12193334
21MP0001849_ear_inflammation2.06593193
22MP0003123_paternal_imprinting1.99604877
23MP0001672_abnormal_embryogenesis/_devel1.93668592
24MP0005380_embryogenesis_phenotype1.93668592
25MP0008932_abnormal_embryonic_tissue1.89358049
26MP0005451_abnormal_body_composition1.85840532
27MP0002396_abnormal_hematopoietic_system1.85380067
28MP0000569_abnormal_digit_pigmentation1.81734720
29MP0003984_embryonic_growth_retardation1.76546312
30MP0003172_abnormal_lysosome_physiology1.74766945
31MP0001697_abnormal_embryo_size1.74460803
32MP0002084_abnormal_developmental_patter1.74396979
33MP0002088_abnormal_embryonic_growth/wei1.72950083
34MP0003890_abnormal_embryonic-extraembry1.69892758
35MP0002085_abnormal_embryonic_tissue1.68256387
36MP0000685_abnormal_immune_system1.67035042
37MP0003705_abnormal_hypodermis_morpholog1.66023435
38MP0002086_abnormal_extraembryonic_tissu1.65793277
39MP0002653_abnormal_ependyma_morphology1.65635728
40MP0002080_prenatal_lethality1.59978220
41MP0004808_abnormal_hematopoietic_stem1.59296348
42MP0004197_abnormal_fetal_growth/weight/1.56264119
43MP0003121_genomic_imprinting1.53674215
44MP0010030_abnormal_orbit_morphology1.52385505
45MP0000490_abnormal_crypts_of1.52223372
46MP0005075_abnormal_melanosome_morpholog1.47970262
47MP0003786_premature_aging1.46647932
48MP0003436_decreased_susceptibility_to1.45618784
49MP0002405_respiratory_system_inflammati1.45251363
50MP0005310_abnormal_salivary_gland1.43375575
51MP0002166_altered_tumor_susceptibility1.43344625
52MP0004233_abnormal_muscle_weight1.42333904
53MP0008260_abnormal_autophagy1.39503631
54MP0003724_increased_susceptibility_to1.36247400
55MP0006082_CNS_inflammation1.35356516
56MP0000703_abnormal_thymus_morphology1.33558670
57MP0004883_abnormal_blood_vessel1.30623469
58MP0000313_abnormal_cell_death1.30461500
59MP0002019_abnormal_tumor_incidence1.28938862
60MP0002723_abnormal_immune_serum1.28418252
61MP0001293_anophthalmia1.27647568
62MP0009697_abnormal_copulation1.27150971
63MP0002419_abnormal_innate_immunity1.25196950
64MP0002398_abnormal_bone_marrow1.23376468
65MP0001873_stomach_inflammation1.23120373
66MP0004133_heterotaxia1.23115736
67MP0000372_irregular_coat_pigmentation1.23104913
68MP0003567_abnormal_fetal_cardiomyocyte1.22743240
69MP0003656_abnormal_erythrocyte_physiolo1.20721664
70MP0004947_skin_inflammation1.18048874
71MP0000733_abnormal_muscle_development1.13733067
72MP0005000_abnormal_immune_tolerance1.12067763
73MP0009333_abnormal_splenocyte_physiolog1.11676347
74MP0000537_abnormal_urethra_morphology1.11484829
75MP0002210_abnormal_sex_determination1.11128753
76MP0003221_abnormal_cardiomyocyte_apopto1.08994516
77MP0003763_abnormal_thymus_physiology1.08106585
78MP0002722_abnormal_immune_system1.06263139
79MP0001851_eye_inflammation1.05877646
80MP0003119_abnormal_digestive_system1.04966084
81MP0003787_abnormal_imprinting1.03718334
82MP0001790_abnormal_immune_system1.02382416
83MP0005387_immune_system_phenotype1.02382416
84MP0003566_abnormal_cell_adhesion1.01799643
85MP0000689_abnormal_spleen_morphology1.01035410
86MP0009278_abnormal_bone_marrow0.99379159
87MP0001929_abnormal_gametogenesis0.98543817
88MP0003453_abnormal_keratinocyte_physiol0.98389290
89MP0005397_hematopoietic_system_phenotyp0.97860613
90MP0001545_abnormal_hematopoietic_system0.97860613
91MP0003045_fibrosis0.97522648
92MP0002132_abnormal_respiratory_system0.97193036
93MP0003943_abnormal_hepatobiliary_system0.97156606
94MP0006292_abnormal_olfactory_placode0.96607772
95MP0005023_abnormal_wound_healing0.96332003
96MP0002006_tumorigenesis0.95398850
97MP0001915_intracranial_hemorrhage0.95262271
98MP0001145_abnormal_male_reproductive0.94878284
99MP0009672_abnormal_birth_weight0.94817455
100MP0003718_maternal_effect0.94090576
101MP0005408_hypopigmentation0.93439580
102MP0005621_abnormal_cell_physiology0.92618414
103MP0005025_abnormal_response_to0.92244226
104MP0001186_pigmentation_phenotype0.92085105
105MP0000427_abnormal_hair_cycle0.91246941
106MP0002092_abnormal_eye_morphology0.91101336
107MP0009053_abnormal_anal_canal0.90625002
108MP0004264_abnormal_extraembryonic_tissu0.89578153
109MP0006054_spinal_hemorrhage0.88251460
110MP0005164_abnormal_response_to0.87340681
111MP0003191_abnormal_cellular_cholesterol0.87207159
112MP0000465_gastrointestinal_hemorrhage0.85627869
113MP0001661_extended_life_span0.85551506
114MP0002429_abnormal_blood_cell0.85495258
115MP0000371_diluted_coat_color0.84794977
116MP0002163_abnormal_gland_morphology0.84318999
117MP0004185_abnormal_adipocyte_glucose0.84163086
118MP0005384_cellular_phenotype0.83303986
119MP0009703_decreased_birth_body0.82854722
120MP0000428_abnormal_craniofacial_morphol0.82851865
121MP0005671_abnormal_response_to0.82235937
122MP0000858_altered_metastatic_potential0.81724261
123MP0001853_heart_inflammation0.81240958
124MP0001800_abnormal_humoral_immune0.80900927
125MP0002877_abnormal_melanocyte_morpholog0.79866601
126MP0000716_abnormal_immune_system0.79511704
127MP0002697_abnormal_eye_size0.79124425
128MP0002332_abnormal_exercise_endurance0.78902279
129MP0005248_abnormal_Harderian_gland0.78664592
130MP0003937_abnormal_limbs/digits/tail_de0.78287474
131MP0002168_other_aberrant_phenotype0.78250734
132MP0000653_abnormal_sex_gland0.77507279
133MP0010234_abnormal_vibrissa_follicle0.76817118
134MP0002925_abnormal_cardiovascular_devel0.76565370
135MP0005174_abnormal_tail_pigmentation0.72900735
136MP0000432_abnormal_head_morphology0.72402132
137MP0000477_abnormal_intestine_morphology0.72356573
138MP0003091_abnormal_cell_migration0.70918489
139MP0002452_abnormal_antigen_presenting0.69489182
140MP0000015_abnormal_ear_pigmentation0.67638266
141MP0001835_abnormal_antigen_presentation0.67250380
142MP0002111_abnormal_tail_morphology0.65890355
143MP0003315_abnormal_perineum_morphology0.65875930
144MP0001119_abnormal_female_reproductive0.65054730
145MP0003303_peritoneal_inflammation0.64834743
146MP0003935_abnormal_craniofacial_develop0.64470731
147MP0003115_abnormal_respiratory_system0.63812875
148MP0002420_abnormal_adaptive_immunity0.63477376
149MP0001819_abnormal_immune_cell0.63404538
150MP0002075_abnormal_coat/hair_pigmentati0.62663444
151MP0003448_altered_tumor_morphology0.61589920

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.97666236
2Impulsivity (HP:0100710)3.76288809
3Medulloblastoma (HP:0002885)3.52168687
4Selective tooth agenesis (HP:0001592)3.50543207
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.48453384
6Birth length less than 3rd percentile (HP:0003561)3.46241007
7Subacute progressive viral hepatitis (HP:0006572)3.44825708
8Chromsome breakage (HP:0040012)3.35079712
9Albinism (HP:0001022)3.18961554
10Recurrent bacterial skin infections (HP:0005406)3.02607838
11Astrocytoma (HP:0009592)2.95529233
12Abnormality of the astrocytes (HP:0100707)2.95529233
13Delayed closure of the anterior fontanelle (HP:0001476)2.95506155
14Agnosia (HP:0010524)2.82834445
15Stomatitis (HP:0010280)2.78016928
16Abnormality of the renal collecting system (HP:0004742)2.76283227
17Abnormality of chromosome stability (HP:0003220)2.73658506
18Patellar aplasia (HP:0006443)2.72311845
19Abnormal number of incisors (HP:0011064)2.64924683
20Ectopic kidney (HP:0000086)2.62816113
21Proximal placement of thumb (HP:0009623)2.61894698
22Meckel diverticulum (HP:0002245)2.59070355
23Deviation of the thumb (HP:0009603)2.58846341
24Recurrent abscess formation (HP:0002722)2.57550073
25Aplasia/Hypoplasia of the patella (HP:0006498)2.56428525
26Glioma (HP:0009733)2.53857156
27Eczematoid dermatitis (HP:0000976)2.53697727
28Rhabdomyosarcoma (HP:0002859)2.53659381
29Prominent nose (HP:0000448)2.53393153
30Increased nuchal translucency (HP:0010880)2.51837260
31Abnormality of the fingertips (HP:0001211)2.51330920
32Dyschromatopsia (HP:0007641)2.50105583
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.49950992
34Short chin (HP:0000331)2.47813971
35Abnormality of the ileum (HP:0001549)2.47587020
36Recurrent fungal infections (HP:0002841)2.47019575
37Colon cancer (HP:0003003)2.46946176
38Neoplasm of the oral cavity (HP:0100649)2.45238282
39Volvulus (HP:0002580)2.44441206
40Abnormality of the labia minora (HP:0012880)2.43397263
41Fair hair (HP:0002286)2.36442783
42T lymphocytopenia (HP:0005403)2.36293741
43Basal cell carcinoma (HP:0002671)2.35839731
44Reticulocytopenia (HP:0001896)2.34765962
45Recurrent viral infections (HP:0004429)2.31203474
46Relative macrocephaly (HP:0004482)2.26809521
47Abnormality of the anterior horn cell (HP:0006802)2.26369246
48Degeneration of anterior horn cells (HP:0002398)2.26369246
49Myelodysplasia (HP:0002863)2.26065808
50Amaurosis fugax (HP:0100576)2.25973917
51Abnormality of T cell number (HP:0011839)2.25937547
52Long eyelashes (HP:0000527)2.23444021
53Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.23272778
54Short 4th metacarpal (HP:0010044)2.23272778
55Neoplasm of the adrenal cortex (HP:0100641)2.19881941
56Abnormality of the preputium (HP:0100587)2.19859550
57Absent thumb (HP:0009777)2.19607650
58Neoplasm of striated muscle (HP:0009728)2.19529814
59Gastrointestinal carcinoma (HP:0002672)2.18130714
60Malignant gastrointestinal tract tumors (HP:0006749)2.18130714
61Absent radius (HP:0003974)2.17256065
62Breast hypoplasia (HP:0003187)2.16626257
63Duodenal stenosis (HP:0100867)2.15771107
64Small intestinal stenosis (HP:0012848)2.15771107
65Cafe-au-lait spot (HP:0000957)2.13201290
66Asymmetry of the thorax (HP:0001555)2.11947379
67Abnormal foot bone ossification (HP:0010675)2.11750899
68Viral hepatitis (HP:0006562)2.11166235
69Natal tooth (HP:0000695)2.08770210
70Abnormality of the carotid arteries (HP:0005344)2.06019791
71Autoimmune hemolytic anemia (HP:0001890)2.05693363
72Hyperacusis (HP:0010780)2.05444403
73High pitched voice (HP:0001620)2.04153426
74Biliary tract neoplasm (HP:0100574)2.03928897
75Abnormality of abdominal situs (HP:0011620)2.03254396
76Abdominal situs inversus (HP:0003363)2.03254396
77Chronic diarrhea (HP:0002028)2.03071045
78Sloping forehead (HP:0000340)2.03051247
79Neoplasm of the pancreas (HP:0002894)2.03002769
80Stenosis of the external auditory canal (HP:0000402)2.02506519
81Overlapping toe (HP:0001845)1.99744381
82Absent forearm bone (HP:0003953)1.99724127
83Aplasia involving forearm bones (HP:0009822)1.99724127
84Heterotopia (HP:0002282)1.99693612
85Spondylolisthesis (HP:0003302)1.99679898
86Skull defect (HP:0001362)1.99461605
87Papillary thyroid carcinoma (HP:0002895)1.99274309
88Recurrent skin infections (HP:0001581)1.96518566
89Skin tags (HP:0010609)1.95935733
90Tracheoesophageal fistula (HP:0002575)1.95838032
91Cutis marmorata (HP:0000965)1.94080307
92Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.93744979
93Facial hemangioma (HP:0000329)1.93698688
94Cutaneous melanoma (HP:0012056)1.90317980
95Abnormality of macrophages (HP:0004311)1.90261521
96Atresia of the external auditory canal (HP:0000413)1.90199579
97Sandal gap (HP:0001852)1.89417282
98Oral leukoplakia (HP:0002745)1.88533449
99Low anterior hairline (HP:0000294)1.87940533
100Smooth philtrum (HP:0000319)1.87850574
101Preauricular skin tag (HP:0000384)1.87660775
102Duplicated collecting system (HP:0000081)1.87627348
103Orthostatic hypotension (HP:0001278)1.87459589
104Anal stenosis (HP:0002025)1.87048994
105Coarse hair (HP:0002208)1.86314363
106Broad palm (HP:0001169)1.85723274
107Neonatal hypoglycemia (HP:0001998)1.85583405
108Supernumerary ribs (HP:0005815)1.84234851
109Abnormality of cochlea (HP:0000375)1.84046982
110Rib fusion (HP:0000902)1.83835660
111Abnormality of the duodenum (HP:0002246)1.83802180
112Capillary hemangiomas (HP:0005306)1.82978910
113Lip pit (HP:0100267)1.82900912
114Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82472529
115Urethral obstruction (HP:0000796)1.81779511
116Abnormality of B cell number (HP:0010975)1.81683072
117Osteomyelitis (HP:0002754)1.81614467
118Poikiloderma (HP:0001029)1.81108112
119Osteolytic defects of the hand bones (HP:0009699)1.80191089
120Osteolytic defects of the phalanges of the hand (HP:0009771)1.80191089
121Increased density of long bones (HP:0006392)1.79854421
122Lower limb hyperreflexia (HP:0002395)1.79239140
123Optic neuritis (HP:0100653)1.78770838
124Retrobulbar optic neuritis (HP:0100654)1.78770838
125Abnormality of DNA repair (HP:0003254)1.78377452
126Missing ribs (HP:0000921)1.78259608
127Widely spaced teeth (HP:0000687)1.78178235
128Hematochezia (HP:0002573)1.78101922
129Spontaneous hematomas (HP:0007420)1.78006658
130Prominent metopic ridge (HP:0005487)1.77986636
131Aplasia/hypoplasia of the humerus (HP:0006507)1.77978617
132Pustule (HP:0200039)1.77487247
133Hypopigmentation of the fundus (HP:0007894)1.75313739
134Short thumb (HP:0009778)1.74890557
135Submucous cleft hard palate (HP:0000176)1.74216312
136Broad ribs (HP:0000885)1.71370919
137Delayed cranial suture closure (HP:0000270)1.71321861
138Carpal bone hypoplasia (HP:0001498)1.71316301
139Supernumerary bones of the axial skeleton (HP:0009144)1.70770957
140Freckling (HP:0001480)1.70655020
141Short humerus (HP:0005792)1.70511692
142Cellulitis (HP:0100658)1.69911541
143Bone marrow hypocellularity (HP:0005528)1.69704664
144Deep philtrum (HP:0002002)1.69482397
145Bladder neoplasm (HP:0009725)1.69194058
146Bladder carcinoma (HP:0002862)1.69194058
147Advanced eruption of teeth (HP:0006288)1.68925468
148IgA deficiency (HP:0002720)1.68674767
149Orchitis (HP:0100796)1.68493630
150Abnormality of the metopic suture (HP:0005556)1.68348687
151Spinal muscular atrophy (HP:0007269)1.67720425
152Obsessive-compulsive behavior (HP:0000722)1.67116090
153Narrow palate (HP:0000189)1.66706244
154Persistence of primary teeth (HP:0006335)1.66586206
155Hip dysplasia (HP:0001385)1.66579038
156Arterial tortuosity (HP:0005116)1.66220937
157Micronodular cirrhosis (HP:0001413)1.66074882
158Septate vagina (HP:0001153)1.65965048
159Supernumerary spleens (HP:0009799)1.65905963
160Entropion (HP:0000621)1.65790499
161Chronic mucocutaneous candidiasis (HP:0002728)1.65339582
162Recurrent cutaneous fungal infections (HP:0011370)1.65339582
163Renal cell carcinoma (HP:0005584)1.64852081
164Generalized hypopigmentation of hair (HP:0011358)1.64174212
165Dysmetric saccades (HP:0000641)1.63723128
166Recurrent bronchitis (HP:0002837)1.63672270
167Squamous cell carcinoma (HP:0002860)1.62325695
168Myocardial infarction (HP:0001658)1.61757538
169Syringomyelia (HP:0003396)1.61684027
170Spinal cord lesions (HP:0100561)1.61684027
171Anhidrosis (HP:0000970)1.61511254
172Slender long bone (HP:0003100)1.61071825
173Renal duplication (HP:0000075)1.60746091
174Acute myeloid leukemia (HP:0004808)1.60382571
175Transitional cell carcinoma of the bladder (HP:0006740)1.60227725
176Global brain atrophy (HP:0002283)1.58846751
177Gastrointestinal infarctions (HP:0005244)1.56106702
178Blepharitis (HP:0000498)1.55207377
179Abnormality of the nasal septum (HP:0000419)1.52906061
180Aplasia cutis congenita (HP:0001057)1.52347358
181Increased IgE level (HP:0003212)1.52195590
182Hypoplasia of the thymus (HP:0000778)1.49772339
183Tented upper lip vermilion (HP:0010804)1.48808932

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.45724244
2CDC74.02024013
3BUB13.39731916
4IRAK33.12596567
5NEK22.94221272
6FRK2.85917516
7BRD42.75078081
8WEE12.68556533
9EEF2K2.53734453
10MAP3K102.52858340
11MAP3K142.35585536
12TTK2.25208235
13TSSK61.99772237
14MKNK11.85161191
15RPS6KB21.85026037
16SIK31.80335894
17STK101.80140481
18ATR1.80119209
19TRPM71.78699228
20PLK41.72551112
21PASK1.71160802
22PLK11.67054135
23CDK71.65520357
24CDK41.65028831
25MAP4K11.63463981
26EPHA21.63168154
27SRPK11.61507520
28SMG11.58000817
29EIF2AK11.50119463
30CHEK11.49210338
31LATS11.46013424
32MAP3K131.44300334
33PLK31.40700265
34TLK11.37642225
35NUAK11.37512941
36MAPKAPK31.37424605
37MKNK21.36411013
38STK31.34751064
39AURKB1.34545630
40ALK1.34450632
41NEK11.33871111
42TGFBR21.33708397
43PKN21.33558125
44MAP3K81.33275060
45CHEK21.32741248
46TYK21.31671120
47MAP2K31.31505125
48RPS6KA41.22795223
49BRSK21.21902831
50PRPF4B1.21191443
51PIM11.19125420
52IRAK11.18857268
53CDK81.17813101
54CCNB11.17009348
55MAPK111.15507476
56STK41.15443326
57PAK41.12857018
58MUSK1.11038664
59IRAK41.11022731
60CDK21.08205396
61YES11.07716841
62SCYL21.07350541
63ATM1.06929519
64ACVR1B1.06358510
65NLK1.06059241
66IKBKE1.05469504
67MTOR1.04686330
68CDK61.02885989
69MAP3K21.00800389
70JAK10.99943217
71DYRK30.96404343
72BLK0.95276900
73PTK60.94910965
74LATS20.93710885
75AKT30.91931367
76CAMK1G0.89144007
77EPHA30.89008031
78SGK30.88348506
79FGR0.87336745
80PDGFRA0.83525482
81SIK20.81296246
82PNCK0.80393230
83CDK10.79135642
84SIK10.78193535
85MAP3K30.76923947
86BRSK10.75819567
87ZAK0.75130466
88IKBKB0.74482768
89AURKA0.74420050
90TAOK30.73752660
91HCK0.72337946
92FER0.71303073
93CHUK0.70797696
94MAP3K70.70050890
95MARK30.66645317
96VRK10.66593421
97GRK60.66221438
98PRKAA20.66153307
99FLT30.65787729
100TYRO30.64977887
101FGFR10.64669131
102TGFBR10.64095147
103PRKCI0.63771637
104JAK30.62981754
105CSK0.62312266
106TESK20.61864007
107RPS6KB10.59998507
108STK38L0.59951180
109EPHB10.59615521
110FGFR40.59122650
111MELK0.58031891
112TRIB30.57676199
113CDK90.57472914
114STK240.55522218
115TTN0.55292799
116EIF2AK30.54921286
117LRRK20.54243290
118CSNK1D0.53425380
119TAOK10.52723008
120ZAP700.52205099
121CSNK1E0.51884891
122MAPK140.51286859
123ICK0.50496820
124VRK20.49559337
125TAOK20.47751099
126FGFR30.47502607
127CSNK2A20.47248605
128NEK60.46551871
129PAK20.45493499
130LCK0.45287165
131TEC0.43344247
132PDK10.43225747
133TAF10.42717316
134RAF10.41851312
135MAPKAPK50.41739945
136PDGFRB0.40689957
137PAK10.40575859
138MAP3K50.40041958
139GSK3B0.39444564
140RPS6KA50.39405632
141PRKDC0.39245355
142FGFR20.38761162
143AKT20.38221685
144LYN0.37616403
145MAP3K10.34958056
146BTK0.34601497
147ITK0.33871129
148BMX0.32698000
149CAMK1D0.31787785
150TESK10.31601137
151PDK30.31560007
152PDK40.31560007

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.99357172
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.54052800
3Mismatch repair_Homo sapiens_hsa034303.53786403
4RNA transport_Homo sapiens_hsa030133.30624419
5* Spliceosome_Homo sapiens_hsa030403.19508890
6Cell cycle_Homo sapiens_hsa041102.69367000
7One carbon pool by folate_Homo sapiens_hsa006702.65042183
8Base excision repair_Homo sapiens_hsa034102.55892949
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.39365002
10Nucleotide excision repair_Homo sapiens_hsa034202.28488937
11Fanconi anemia pathway_Homo sapiens_hsa034602.27529428
12RNA polymerase_Homo sapiens_hsa030202.25624430
13Homologous recombination_Homo sapiens_hsa034402.22030815
14mRNA surveillance pathway_Homo sapiens_hsa030152.18553940
15RNA degradation_Homo sapiens_hsa030181.75285637
16Non-homologous end-joining_Homo sapiens_hsa034501.63881267
17Pyrimidine metabolism_Homo sapiens_hsa002401.63789377
18p53 signaling pathway_Homo sapiens_hsa041151.62568543
19Basal transcription factors_Homo sapiens_hsa030221.54538652
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.46871988
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44503392
22Systemic lupus erythematosus_Homo sapiens_hsa053221.39933233
23Epstein-Barr virus infection_Homo sapiens_hsa051691.39527745
24Viral carcinogenesis_Homo sapiens_hsa052031.35322796
25Other glycan degradation_Homo sapiens_hsa005111.34260933
26Ribosome_Homo sapiens_hsa030101.30561722
27MicroRNAs in cancer_Homo sapiens_hsa052061.27453326
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26708621
29Antigen processing and presentation_Homo sapiens_hsa046121.25220460
30Herpes simplex infection_Homo sapiens_hsa051681.22769210
31Proteasome_Homo sapiens_hsa030501.20047254
32Hepatitis C_Homo sapiens_hsa051601.17392106
33HTLV-I infection_Homo sapiens_hsa051661.13216817
34Sphingolipid metabolism_Homo sapiens_hsa006001.10561418
35Small cell lung cancer_Homo sapiens_hsa052221.08453571
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08295705
37Tuberculosis_Homo sapiens_hsa051521.06764080
38Chronic myeloid leukemia_Homo sapiens_hsa052201.05084700
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03323878
40Lysine degradation_Homo sapiens_hsa003101.01480472
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00009845
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99503403
43Inositol phosphate metabolism_Homo sapiens_hsa005620.97385085
44Selenocompound metabolism_Homo sapiens_hsa004500.96794944
45Sulfur metabolism_Homo sapiens_hsa009200.95064373
46Notch signaling pathway_Homo sapiens_hsa043300.93978233
47Insulin resistance_Homo sapiens_hsa049310.91782490
48Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91650986
49Oocyte meiosis_Homo sapiens_hsa041140.90757277
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90462310
51Sphingolipid signaling pathway_Homo sapiens_hsa040710.90392678
52Dorso-ventral axis formation_Homo sapiens_hsa043200.89490621
53Glioma_Homo sapiens_hsa052140.89256406
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87786980
55mTOR signaling pathway_Homo sapiens_hsa041500.87247170
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.85554824
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.84904984
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84721968
59Hippo signaling pathway_Homo sapiens_hsa043900.82820436
60Primary immunodeficiency_Homo sapiens_hsa053400.82571224
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82261619
62Purine metabolism_Homo sapiens_hsa002300.82227872
63Adherens junction_Homo sapiens_hsa045200.81431220
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80409603
65Basal cell carcinoma_Homo sapiens_hsa052170.80143489
66Colorectal cancer_Homo sapiens_hsa052100.79124797
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78789018
68Acute myeloid leukemia_Homo sapiens_hsa052210.77476455
69Apoptosis_Homo sapiens_hsa042100.75213193
70Platelet activation_Homo sapiens_hsa046110.74142280
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73239131
72Thyroid cancer_Homo sapiens_hsa052160.73039377
73Chemokine signaling pathway_Homo sapiens_hsa040620.71677666
74N-Glycan biosynthesis_Homo sapiens_hsa005100.71358373
75Measles_Homo sapiens_hsa051620.71233570
76Shigellosis_Homo sapiens_hsa051310.69971754
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.69518815
78ErbB signaling pathway_Homo sapiens_hsa040120.67735120
79B cell receptor signaling pathway_Homo sapiens_hsa046620.66603114
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65711524
81TGF-beta signaling pathway_Homo sapiens_hsa043500.65113055
82Proteoglycans in cancer_Homo sapiens_hsa052050.64519249
83Hepatitis B_Homo sapiens_hsa051610.64295518
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.64058644
85Influenza A_Homo sapiens_hsa051640.64051160
86Viral myocarditis_Homo sapiens_hsa054160.62971511
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61455358
88Choline metabolism in cancer_Homo sapiens_hsa052310.61434455
89Legionellosis_Homo sapiens_hsa051340.61425482
90T cell receptor signaling pathway_Homo sapiens_hsa046600.61028972
91Fatty acid biosynthesis_Homo sapiens_hsa000610.61023779
92Pentose phosphate pathway_Homo sapiens_hsa000300.60863111
93Non-small cell lung cancer_Homo sapiens_hsa052230.60628782
94HIF-1 signaling pathway_Homo sapiens_hsa040660.60156339
95Lysosome_Homo sapiens_hsa041420.59785528
96Type II diabetes mellitus_Homo sapiens_hsa049300.59157109
97Prostate cancer_Homo sapiens_hsa052150.59050456
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56802955
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56575272
100Pathways in cancer_Homo sapiens_hsa052000.56247078
101Biosynthesis of amino acids_Homo sapiens_hsa012300.55514091
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55097777
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.54459114
104Malaria_Homo sapiens_hsa051440.52454036
105Endometrial cancer_Homo sapiens_hsa052130.51970279
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51428471
107Leishmaniasis_Homo sapiens_hsa051400.50762961
108Vitamin B6 metabolism_Homo sapiens_hsa007500.46507054
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.45831339
110FoxO signaling pathway_Homo sapiens_hsa040680.45484599
111Toxoplasmosis_Homo sapiens_hsa051450.44444281
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.44284152
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43842855
114Alcoholism_Homo sapiens_hsa050340.43081649
115Pancreatic cancer_Homo sapiens_hsa052120.42283989
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39687338
117Bladder cancer_Homo sapiens_hsa052190.38968631
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.38446289
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38388324
120Osteoclast differentiation_Homo sapiens_hsa043800.36643093
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.35093985
122Hematopoietic cell lineage_Homo sapiens_hsa046400.34905302
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32602416
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32572515
125Prolactin signaling pathway_Homo sapiens_hsa049170.32173062
126Wnt signaling pathway_Homo sapiens_hsa043100.31746807
127VEGF signaling pathway_Homo sapiens_hsa043700.31646033
128Hedgehog signaling pathway_Homo sapiens_hsa043400.31425826
129Renal cell carcinoma_Homo sapiens_hsa052110.30173108
130TNF signaling pathway_Homo sapiens_hsa046680.30083850

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