DHX9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.87222075
2nuclear pore organization (GO:0006999)5.65552449
3pre-miRNA processing (GO:0031054)5.50788065
4mitotic sister chromatid cohesion (GO:0007064)5.32218859
5DNA strand elongation involved in DNA replication (GO:0006271)4.75488135
6DNA strand elongation (GO:0022616)4.63313070
7DNA unwinding involved in DNA replication (GO:0006268)4.58943050
8regulation of RNA export from nucleus (GO:0046831)4.50370765
9heterochromatin organization (GO:0070828)4.33599697
10DNA replication initiation (GO:0006270)4.31818808
11pore complex assembly (GO:0046931)4.24789359
12protein localization to kinetochore (GO:0034501)4.21237969
13negative regulation of histone methylation (GO:0031061)4.17035379
14establishment of integrated proviral latency (GO:0075713)4.09873574
15protein complex localization (GO:0031503)4.04874422
16cellular protein complex localization (GO:0034629)4.02172312
17mitotic metaphase plate congression (GO:0007080)3.99001282
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.93074535
19sister chromatid segregation (GO:0000819)3.92604018
20non-recombinational repair (GO:0000726)3.87577344
21double-strand break repair via nonhomologous end joining (GO:0006303)3.87577344
22negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.85269802
23regulation of sister chromatid cohesion (GO:0007063)3.82319238
24telomere maintenance via semi-conservative replication (GO:0032201)3.81763965
25mitotic chromosome condensation (GO:0007076)3.77205367
26dosage compensation (GO:0007549)3.75941363
27regulation of histone H3-K9 methylation (GO:0051570)3.75611660
28glucocorticoid receptor signaling pathway (GO:0042921)3.74432079
29ribosome assembly (GO:0042255)3.72445202
30cytoplasmic mRNA processing body assembly (GO:0033962)3.72248316
31mitotic nuclear envelope disassembly (GO:0007077)3.69207939
32formation of translation preinitiation complex (GO:0001731)3.67715382
33chromatin assembly (GO:0031497)3.65046518
34regulation of nucleobase-containing compound transport (GO:0032239)3.63005704
35nuclear envelope disassembly (GO:0051081)3.56145491
36membrane disassembly (GO:0030397)3.56145491
37NLS-bearing protein import into nucleus (GO:0006607)3.50119533
38* mRNA stabilization (GO:0048255)3.48875121
39* RNA stabilization (GO:0043489)3.48875121
40spliceosomal tri-snRNP complex assembly (GO:0000244)3.48694979
41peptidyl-lysine dimethylation (GO:0018027)3.48457871
42* DNA duplex unwinding (GO:0032508)3.47814294
43* DNA geometric change (GO:0032392)3.46583171
44protein localization to chromosome, centromeric region (GO:0071459)3.46005045
45negative regulation of RNA splicing (GO:0033119)3.45532877
46regulation of DNA endoreduplication (GO:0032875)3.45308411
47regulation of translational fidelity (GO:0006450)3.44399110
48negative regulation of mRNA processing (GO:0050686)3.42537766
49metaphase plate congression (GO:0051310)3.39904252
50mitotic sister chromatid segregation (GO:0000070)3.37483055
51telomere maintenance via recombination (GO:0000722)3.34948164
52mitotic recombination (GO:0006312)3.34172466
53positive regulation of cell cycle checkpoint (GO:1901978)3.33784954
54paraxial mesoderm development (GO:0048339)3.32207583
55positive regulation of mitotic sister chromatid separation (GO:1901970)3.30118492
56positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.30118492
57positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.30118492
58regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.28206886
59histone H2A monoubiquitination (GO:0035518)3.28089343
60negative regulation of mRNA metabolic process (GO:1903312)3.27893230
61regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.27881480
62DNA replication-dependent nucleosome assembly (GO:0006335)3.24728670
63DNA replication-dependent nucleosome organization (GO:0034723)3.24728670
64protein export from nucleus (GO:0006611)3.22880852
65DNA replication checkpoint (GO:0000076)3.21237786
66alternative mRNA splicing, via spliceosome (GO:0000380)3.19607347
67DNA packaging (GO:0006323)3.19500147
68positive regulation of chromosome segregation (GO:0051984)3.19426475
69positive regulation of RNA splicing (GO:0033120)3.17815665
70DNA synthesis involved in DNA repair (GO:0000731)3.15646859
71negative regulation of DNA repair (GO:0045738)3.14051331
72regulation of posttranscriptional gene silencing (GO:0060147)3.11648465
73regulation of gene silencing by miRNA (GO:0060964)3.11648465
74regulation of gene silencing by RNA (GO:0060966)3.11648465
75DNA topological change (GO:0006265)3.10557811
76folic acid-containing compound biosynthetic process (GO:0009396)3.08309464
77regulation of centrosome cycle (GO:0046605)3.07832431
78establishment of chromosome localization (GO:0051303)3.05374399
79ATP-dependent chromatin remodeling (GO:0043044)3.05104578
80corticosteroid receptor signaling pathway (GO:0031958)3.05056389
81gene silencing by RNA (GO:0031047)3.04511278
82regulation of translational termination (GO:0006449)3.01150721
83DNA ligation (GO:0006266)3.00006793
84negative regulation of chromosome segregation (GO:0051985)2.99438673
85IMP metabolic process (GO:0046040)2.95614971
86translesion synthesis (GO:0019985)2.94714699
87RNA export from nucleus (GO:0006405)2.92458969
88regulation of centrosome duplication (GO:0010824)2.92152278
89regulation of mitotic spindle organization (GO:0060236)2.91351275
90gene silencing (GO:0016458)2.90115000
91establishment of viral latency (GO:0019043)2.89353146
92spindle checkpoint (GO:0031577)2.88971896
93V(D)J recombination (GO:0033151)2.88971423
94mRNA export from nucleus (GO:0006406)2.87492136
95negative regulation of histone modification (GO:0031057)2.87471006
96chromatin assembly or disassembly (GO:0006333)2.86226698
97sister chromatid cohesion (GO:0007062)2.86072209
98hippo signaling (GO:0035329)2.85995371
99chromosome segregation (GO:0007059)2.85705599
100regulation of spindle organization (GO:0090224)2.84990495
101nuclear envelope organization (GO:0006998)2.84925757
102COPI coating of Golgi vesicle (GO:0048205)2.84880801
103Golgi transport vesicle coating (GO:0048200)2.84880801
104nucleobase biosynthetic process (GO:0046112)2.84696377
105negative regulation of sister chromatid segregation (GO:0033046)2.84644340
106negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84644340
107negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.84644340
108negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84644340
109negative regulation of mitotic sister chromatid separation (GO:2000816)2.84644340
110* regulation of mRNA stability (GO:0043488)2.83232977
111mitotic spindle checkpoint (GO:0071174)2.82887992
112mRNA transport (GO:0051028)2.82650939
113positive regulation of SMAD protein import into nucleus (GO:0060391)2.82508921
114regulation of centriole replication (GO:0046599)2.79295598
115* DNA conformation change (GO:0071103)2.79029962
116regulation of DNA damage checkpoint (GO:2000001)2.78351010
117histone H3-K9 methylation (GO:0051567)2.76470146
118histone H3-K9 demethylation (GO:0033169)2.75432389
119protein localization to chromosome (GO:0034502)2.75149943
120negative regulation of chromatin modification (GO:1903309)2.73797487
121nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.71659085
122mRNA splice site selection (GO:0006376)2.68918123
123positive regulation of gene expression, epigenetic (GO:0045815)2.67658540
124chromosome condensation (GO:0030261)2.66627398
125histone H3-K36 demethylation (GO:0070544)2.65946532
126kinetochore organization (GO:0051383)2.65492273
127IMP biosynthetic process (GO:0006188)2.64697901
128chromatin silencing (GO:0006342)2.63919033
129protein-DNA complex disassembly (GO:0032986)2.61669122
130nucleosome disassembly (GO:0006337)2.61669122
131regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.61637077
132nucleic acid transport (GO:0050657)2.60617291
133RNA transport (GO:0050658)2.60617291
134establishment of RNA localization (GO:0051236)2.60617291
135spindle assembly involved in mitosis (GO:0090307)2.60326284
136monoubiquitinated protein deubiquitination (GO:0035520)2.59832110
137* regulation of RNA stability (GO:0043487)2.59155969
138microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.58149199
139histone mRNA catabolic process (GO:0071044)2.58047625
140trophectodermal cell differentiation (GO:0001829)2.58009985
141regulation of chromosome segregation (GO:0051983)2.57155507
142peptidyl-arginine methylation (GO:0018216)2.56090658
143peptidyl-arginine N-methylation (GO:0035246)2.56090658
144regulation of stem cell maintenance (GO:2000036)2.55891739

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.23395318
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.65370983
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.79286871
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.36299515
5MYC_22102868_ChIP-Seq_BL_Human3.35315216
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.17580619
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.94640726
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91422723
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.89312784
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.26926834
11* E2F1_21310950_ChIP-Seq_MCF-7_Human2.25946701
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19581063
13AR_21909140_ChIP-Seq_LNCAP_Human2.13260790
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.11040296
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.01218949
16E2F7_22180533_ChIP-Seq_HELA_Human10.1530287
17CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95247976
18SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.83337633
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.83156804
20* TCF7_22412390_ChIP-Seq_EML_Mouse1.80882336
21* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.80807838
22TTF2_22483619_ChIP-Seq_HELA_Human1.75240744
23DCP1A_22483619_ChIP-Seq_HELA_Human1.74732016
24CIITA_25753668_ChIP-Seq_RAJI_Human1.74591393
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.73228502
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71445442
27* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69362855
28ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.68949238
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.66879383
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66562227
31KDM2B_26808549_Chip-Seq_DND41_Human1.64320947
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.61269373
33* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.60829015
34CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.57916559
35VDR_21846776_ChIP-Seq_THP-1_Human1.57150059
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57138482
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.55502498
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53547090
39* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48826286
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48461427
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47903658
42DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.47351882
43* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.47267987
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46923652
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46370732
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45461512
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44873157
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44493604
49KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.43383197
50KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.43383197
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.43383197
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43058264
53ETS1_20019798_ChIP-Seq_JURKAT_Human1.42280568
54* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42014648
55* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41927251
56FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.41784232
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41375747
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40834459
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39743267
60KDM5A_27292631_Chip-Seq_BREAST_Human1.36798136
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.36029924
62NANOG_21062744_ChIP-ChIP_HESCs_Human1.34410472
63* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34075551
64CLOCK_20551151_ChIP-Seq_293T_Human1.33745962
65* CHD1_26751641_Chip-Seq_LNCaP_Human1.33665074
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33345997
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32625175
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31508001
69ELK1_19687146_ChIP-ChIP_HELA_Human1.29171693
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28129625
71* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.27513285
72XRN2_22483619_ChIP-Seq_HELA_Human1.26807827
73* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26018950
74* GABP_19822575_ChIP-Seq_HepG2_Human1.25500403
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25311530
76* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.25282420
77UTX_26944678_Chip-Seq_JUKART_Human1.23624762
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22436821
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21021247
80FOXP3_21729870_ChIP-Seq_TREG_Human1.19667751
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19087941
82* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18370138
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18299661
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.17364029
85* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16484732
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16359217
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15999246
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15524897
89FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14833568
90TP63_17297297_ChIP-ChIP_HaCaT_Human1.14267217
91ZNF263_19887448_ChIP-Seq_K562_Human1.13735394
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13039824
93TCF3_18692474_ChIP-Seq_MEFs_Mouse1.13035408
94* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12170433
95NCOR1_26117541_ChIP-Seq_K562_Human1.11945043
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11447026
97* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.11323930
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10255869
99* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08987785
100KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08802486
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06287521
102HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06036154
103* MAF_26560356_Chip-Seq_TH1_Human1.05280255
104TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05234304
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04673161
106TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04110927
107* ELK3_25401928_ChIP-Seq_HUVEC_Human1.04108989
108EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04037829
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03596684
110ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02844487
111SOX17_20123909_ChIP-Seq_XEN_Mouse1.01902314
112CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01535716
113SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01374291
114GABP_17652178_ChIP-ChIP_JURKAT_Human0.99111333
115NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96891345
116STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96377947
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95099570
118VDR_23849224_ChIP-Seq_CD4+_Human0.94984390
119SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94402752
120TFEB_21752829_ChIP-Seq_HELA_Human0.94354734
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94011767
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93998776
123TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93503187
124POU5F1_16518401_ChIP-PET_MESCs_Mouse0.92437804
125PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92358294
126EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91885631
127RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91463709
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91401767
129* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91375430
130* GATA6_25053715_ChIP-Seq_YYC3_Human0.90043670
131ATF3_27146783_Chip-Seq_COLON_Human0.90028335
132FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.90000520
133MYB_26560356_Chip-Seq_TH1_Human0.89903788
134POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.87707904
135NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84797512
136POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84125692
137SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84100849
138SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82853487
139SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79819367
140GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78675233
141* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.76879302
142WT1_19549856_ChIP-ChIP_CCG9911_Human0.75209246
143SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73942620

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.33891509
2MP0005076_abnormal_cell_differentiation3.26387262
3MP0003705_abnormal_hypodermis_morpholog3.01415713
4MP0010094_abnormal_chromosome_stability2.99343752
5MP0003111_abnormal_nucleus_morphology2.91902771
6MP0008057_abnormal_DNA_replication2.72460965
7MP0002009_preneoplasia2.68648385
8MP0000569_abnormal_digit_pigmentation2.49751357
9MP0003077_abnormal_cell_cycle2.49695291
10MP0003123_paternal_imprinting2.44627774
11MP0004957_abnormal_blastocyst_morpholog2.41707051
12MP0010307_abnormal_tumor_latency2.38017876
13MP0000537_abnormal_urethra_morphology2.32728320
14MP0010234_abnormal_vibrissa_follicle2.31044052
15MP0004197_abnormal_fetal_growth/weight/2.23957812
16MP0003693_abnormal_embryo_hatching2.20662309
17MP0001730_embryonic_growth_arrest2.18935464
18MP0003121_genomic_imprinting2.16006873
19MP0009053_abnormal_anal_canal2.12792580
20MP0000350_abnormal_cell_proliferation2.10264895
21MP0003890_abnormal_embryonic-extraembry2.05892210
22* MP0002084_abnormal_developmental_patter2.01373465
23* MP0001672_abnormal_embryogenesis/_devel1.87746757
24* MP0005380_embryogenesis_phenotype1.87746757
25MP0003984_embryonic_growth_retardation1.82113407
26MP0002088_abnormal_embryonic_growth/wei1.80994863
27MP0009697_abnormal_copulation1.80183021
28* MP0002085_abnormal_embryonic_tissue1.79080134
29* MP0002086_abnormal_extraembryonic_tissu1.77195532
30MP0001697_abnormal_embryo_size1.73515051
31MP0003567_abnormal_fetal_cardiomyocyte1.67496465
32MP0010030_abnormal_orbit_morphology1.67275760
33MP0008007_abnormal_cellular_replicative1.63714274
34MP0009278_abnormal_bone_marrow1.63626871
35MP0000733_abnormal_muscle_development1.61500161
36MP0004808_abnormal_hematopoietic_stem1.59998503
37MP0003300_gastrointestinal_ulcer1.59907471
38MP0008877_abnormal_DNA_methylation1.59326816
39MP0001849_ear_inflammation1.57836944
40MP0009703_decreased_birth_body1.51136232
41MP0000428_abnormal_craniofacial_morphol1.49968309
42MP0005187_abnormal_penis_morphology1.49302276
43MP0002396_abnormal_hematopoietic_system1.48238069
44MP0003787_abnormal_imprinting1.47085909
45* MP0002080_prenatal_lethality1.44893130
46MP0003566_abnormal_cell_adhesion1.44316306
47MP0003119_abnormal_digestive_system1.40579393
48MP0009672_abnormal_birth_weight1.40123627
49MP0001293_anophthalmia1.37828527
50MP0002877_abnormal_melanocyte_morpholog1.36618391
51MP0008932_abnormal_embryonic_tissue1.31325501
52MP0003115_abnormal_respiratory_system1.29945685
53MP0003935_abnormal_craniofacial_develop1.28867204
54MP0003937_abnormal_limbs/digits/tail_de1.28772996
55MP0002697_abnormal_eye_size1.27845209
56MP0008058_abnormal_DNA_repair1.27065333
57MP0002092_abnormal_eye_morphology1.26126568
58MP0000566_synostosis1.23125893
59MP0005623_abnormal_meninges_morphology1.23074045
60MP0003221_abnormal_cardiomyocyte_apopto1.19466964
61MP0004264_abnormal_extraembryonic_tissu1.16216612
62MP0002925_abnormal_cardiovascular_devel1.14094946
63MP0003283_abnormal_digestive_organ1.13305866
64MP0003786_premature_aging1.12473069
65MP0000432_abnormal_head_morphology1.11874443
66MP0001915_intracranial_hemorrhage1.11021466
67MP0010678_abnormal_skin_adnexa1.05488590
68MP0003385_abnormal_body_wall1.04837611
69MP0004185_abnormal_adipocyte_glucose1.03452829
70MP0003861_abnormal_nervous_system1.01046249
71MP0008961_abnormal_basal_metabolism1.00722529
72MP0002111_abnormal_tail_morphology0.98017203
73MP0000703_abnormal_thymus_morphology0.96882883
74MP0006054_spinal_hemorrhage0.96789411
75MP0001661_extended_life_span0.95993432
76MP0005248_abnormal_Harderian_gland0.95541789
77MP0003091_abnormal_cell_migration0.92428584
78MP0001286_abnormal_eye_development0.92023727
79MP0003755_abnormal_palate_morphology0.91911359
80MP0000490_abnormal_crypts_of0.91474826
81MP0002932_abnormal_joint_morphology0.90525481
82MP0003122_maternal_imprinting0.90225248
83MP0002233_abnormal_nose_morphology0.89845062
84MP0005023_abnormal_wound_healing0.89447422
85MP0005384_cellular_phenotype0.89360929
86MP0003718_maternal_effect0.88829002
87MP0004233_abnormal_muscle_weight0.88158986
88MP0001346_abnormal_lacrimal_gland0.88018062
89MP0003315_abnormal_perineum_morphology0.87378202
90MP0003942_abnormal_urinary_system0.87020858
91MP0002653_abnormal_ependyma_morphology0.86957960
92* MP0000313_abnormal_cell_death0.86876875
93MP0008770_decreased_survivor_rate0.85518115
94MP0002019_abnormal_tumor_incidence0.84296906
95MP0003943_abnormal_hepatobiliary_system0.82658569
96MP0002166_altered_tumor_susceptibility0.81933840
97MP0002116_abnormal_craniofacial_bone0.81765577
98MP0005367_renal/urinary_system_phenotyp0.79919489
99MP0000516_abnormal_urinary_system0.79919489
100MP0000534_abnormal_ureter_morphology0.79442275
101MP0005501_abnormal_skin_physiology0.78956648
102MP0000266_abnormal_heart_morphology0.78789267
103MP0000383_abnormal_hair_follicle0.77666657
104MP0001784_abnormal_fluid_regulation0.76107137
105MP0005621_abnormal_cell_physiology0.75067484
106MP0000358_abnormal_cell_content/0.74765123
107MP0002114_abnormal_axial_skeleton0.73888820
108MP0002796_impaired_skin_barrier0.71675530
109MP0002060_abnormal_skin_morphology0.70875333
110MP0002081_perinatal_lethality0.70024359
111MP0010630_abnormal_cardiac_muscle0.69763188
112MP0003941_abnormal_skin_development0.69576962
113MP0000477_abnormal_intestine_morphology0.68381756
114MP0000627_abnormal_mammary_gland0.67836853
115MP0005397_hematopoietic_system_phenotyp0.67680073
116MP0001545_abnormal_hematopoietic_system0.67680073
117MP0001340_abnormal_eyelid_morphology0.66109678
118MP0005409_darkened_coat_color0.65887853
119MP0002234_abnormal_pharynx_morphology0.65428393
120MP0002006_tumorigenesis0.65417214
121MP0000579_abnormal_nail_morphology0.65152093
122MP0002098_abnormal_vibrissa_morphology0.62889819
123MP0000377_abnormal_hair_follicle0.61133967
124MP0001727_abnormal_embryo_implantation0.60604719
125MP0000762_abnormal_tongue_morphology0.60322418
126MP0001299_abnormal_eye_distance/0.59778265

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.68929047
2Volvulus (HP:0002580)3.62029728
3Short 4th metacarpal (HP:0010044)3.55202102
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.55202102
5Ependymoma (HP:0002888)3.27217121
6Hyperacusis (HP:0010780)3.23712150
7Increased nuchal translucency (HP:0010880)3.15319321
8Cortical dysplasia (HP:0002539)3.14275208
9Abnormality of the astrocytes (HP:0100707)3.03725544
10Astrocytoma (HP:0009592)3.03725544
11Renal duplication (HP:0000075)2.89596849
12Abnormality of the 4th metacarpal (HP:0010012)2.82149219
13Macroorchidism (HP:0000053)2.80412289
14Proximal placement of thumb (HP:0009623)2.75857958
15Deviation of the thumb (HP:0009603)2.74393923
16Heterotopia (HP:0002282)2.67384294
17Pseudobulbar signs (HP:0002200)2.65035075
18Renovascular hypertension (HP:0100817)2.62999454
19Nephroblastoma (Wilms tumor) (HP:0002667)2.62065005
20Medulloblastoma (HP:0002885)2.60816913
21Sparse lateral eyebrow (HP:0005338)2.58725520
22Abnormality of chromosome stability (HP:0003220)2.55361543
23Abnormality of the fingertips (HP:0001211)2.53971464
24Elfin facies (HP:0004428)2.52442986
25Overlapping toe (HP:0001845)2.47497080
26Glioma (HP:0009733)2.45306466
27Long eyelashes (HP:0000527)2.44604841
28Termporal pattern (HP:0011008)2.43707904
29Insidious onset (HP:0003587)2.43707904
30Embryonal renal neoplasm (HP:0011794)2.43641997
31Birth length less than 3rd percentile (HP:0003561)2.42541101
32Subacute progressive viral hepatitis (HP:0006572)2.33288486
33Abnormality of the preputium (HP:0100587)2.33167998
34Malignant gastrointestinal tract tumors (HP:0006749)2.30649638
35Gastrointestinal carcinoma (HP:0002672)2.30649638
36Overriding aorta (HP:0002623)2.30033212
37Obsessive-compulsive behavior (HP:0000722)2.29749225
38Colon cancer (HP:0003003)2.28839067
39Microvesicular hepatic steatosis (HP:0001414)2.28397844
40Progressive external ophthalmoplegia (HP:0000590)2.27165348
41Neoplasm of the oral cavity (HP:0100649)2.27133908
42Selective tooth agenesis (HP:0001592)2.25666186
43Shallow orbits (HP:0000586)2.24752428
44Meckel diverticulum (HP:0002245)2.21023117
45Multiple enchondromatosis (HP:0005701)2.19316267
46Bowel diverticulosis (HP:0005222)2.18163823
47Trigonocephaly (HP:0000243)2.14734052
48Anal stenosis (HP:0002025)2.12669798
49Rectal prolapse (HP:0002035)2.10003923
50Skull defect (HP:0001362)2.09922439
51Broad thumb (HP:0011304)2.09646830
52Abnormality of the labia minora (HP:0012880)2.09438967
53Biliary tract neoplasm (HP:0100574)2.09268545
54Neoplasm of striated muscle (HP:0009728)2.09011476
55Ectopic kidney (HP:0000086)2.08575654
56Abnormality of the ileum (HP:0001549)2.07991315
57Spastic diplegia (HP:0001264)2.04539870
58Prominent nose (HP:0000448)2.03550236
59Aplasia/Hypoplasia of the uvula (HP:0010293)2.03449602
60Supernumerary ribs (HP:0005815)2.02926041
61Myelodysplasia (HP:0002863)2.02108539
62Abnormality of the diencephalon (HP:0010662)2.01082607
63Facial cleft (HP:0002006)2.00909249
64Rhabdomyosarcoma (HP:0002859)2.00557129
65Spinal cord lesions (HP:0100561)2.00469538
66Syringomyelia (HP:0003396)2.00469538
67Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.00122805
68Cerebral aneurysm (HP:0004944)1.99346016
69Truncal obesity (HP:0001956)1.97534860
70Trismus (HP:0000211)1.96733990
71Cutis marmorata (HP:0000965)1.95247036
72Septate vagina (HP:0001153)1.93376329
73Pointed chin (HP:0000307)1.92452560
74Urethral obstruction (HP:0000796)1.92062572
75Abnormality of the calcaneus (HP:0008364)1.91640929
76Broad palm (HP:0001169)1.91168867
77Ankyloglossia (HP:0010296)1.91074830
78Sandal gap (HP:0001852)1.89755514
79Insomnia (HP:0100785)1.89108757
80Basal cell carcinoma (HP:0002671)1.89079909
81Transitional cell carcinoma of the bladder (HP:0006740)1.89070297
82Relative macrocephaly (HP:0004482)1.88515524
83Facial hemangioma (HP:0000329)1.86878288
84Small intestinal stenosis (HP:0012848)1.86795856
85Duodenal stenosis (HP:0100867)1.86795856
86Flat cornea (HP:0007720)1.86550459
87Increased density of long bones (HP:0006392)1.86424000
88Narrow palate (HP:0000189)1.85411487
89Deep philtrum (HP:0002002)1.84875491
90Abnormal number of incisors (HP:0011064)1.84757874
91Leiomyosarcoma (HP:0100243)1.83426654
92Uterine leiomyosarcoma (HP:0002891)1.83426654
93Skin tags (HP:0010609)1.81960791
94Choanal atresia (HP:0000453)1.80855015
95Sacral dimple (HP:0000960)1.79976330
96Absent frontal sinuses (HP:0002688)1.79818446
97Deviation of the hallux (HP:0010051)1.79707049
98High pitched voice (HP:0001620)1.79545300
99Hallux valgus (HP:0001822)1.79110267
100Absent radius (HP:0003974)1.78909991
101Abnormality of the lower motor neuron (HP:0002366)1.78679870
102Dysmetric saccades (HP:0000641)1.78136250
103Glossoptosis (HP:0000162)1.78003083
104Abnormal foot bone ossification (HP:0010675)1.77298655
105Low anterior hairline (HP:0000294)1.75137596
106Long palpebral fissure (HP:0000637)1.74309280
107Short phalanx of the thumb (HP:0009660)1.73485545
108Fibrous tissue neoplasm (HP:0012316)1.73465251
109Progressive muscle weakness (HP:0003323)1.73131664
110Supernumerary bones of the axial skeleton (HP:0009144)1.73124021
111Large earlobe (HP:0009748)1.72906474
112Ulnar bowing (HP:0003031)1.72711735
113Bladder carcinoma (HP:0002862)1.72557249
114Bladder neoplasm (HP:0009725)1.72557249
115Acute myeloid leukemia (HP:0004808)1.72424654
116Atresia of the external auditory canal (HP:0000413)1.71969060
117Abnormality of cochlea (HP:0000375)1.70425340
118Abnormality of oral frenula (HP:0000190)1.69971174
119Enlarged penis (HP:0000040)1.69828026
120Smooth philtrum (HP:0000319)1.69128596
121Hypoplastic labia majora (HP:0000059)1.68861493
122Embryonal neoplasm (HP:0002898)1.68760529
123Broad phalanges of the hand (HP:0009768)1.68338227
124Missing ribs (HP:0000921)1.68260655
125Papillary thyroid carcinoma (HP:0002895)1.68153917
126Fibroma (HP:0010614)1.68045650
127Chromsome breakage (HP:0040012)1.67980039
128Pelvic girdle muscle weakness (HP:0003749)1.67678658
129Cafe-au-lait spot (HP:0000957)1.67346040
130Abnormality of chromosome segregation (HP:0002916)1.66994455
131Bladder diverticulum (HP:0000015)1.65619843
132Uterine neoplasm (HP:0010784)1.65234319
133Megalocornea (HP:0000485)1.64772251
134Abnormality of the distal phalanx of the thumb (HP:0009617)1.63307275
135Preauricular skin tag (HP:0000384)1.63304811
136Hypopigmentation of the fundus (HP:0007894)1.63046017
137Asymmetry of the thorax (HP:0001555)1.62893181
138Limited elbow extension (HP:0001377)1.62844848
139Spina bifida occulta (HP:0003298)1.62686866
140Vertebral arch anomaly (HP:0008438)1.62318888
141Abnormality of the carotid arteries (HP:0005344)1.61805666
142Patellar dislocation (HP:0002999)1.61532298
14311 pairs of ribs (HP:0000878)1.60731630
144Absent forearm bone (HP:0003953)1.59986845
145Aplasia involving forearm bones (HP:0009822)1.59986845
146High anterior hairline (HP:0009890)1.59372099
147Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.59263991
148Renal cell carcinoma (HP:0005584)1.59013930
149Radioulnar synostosis (HP:0002974)1.58953853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.53560463
2CDC73.67289847
3EEF2K3.26300013
4PKN22.86603660
5MAP3K102.83967527
6BRD42.83733302
7SMG12.65833844
8BUB12.64832561
9LATS12.44002336
10TRIB32.32362225
11NEK22.27987620
12EIF2AK12.00873308
13ALK1.91814558
14CDK61.89635667
15PBK1.87506699
16SCYL21.75152654
17ICK1.65657923
18PLK41.62724437
19CAMK1D1.59648515
20RPS6KB21.58632996
21PDGFRA1.58468732
22MKNK11.55921237
23PASK1.55673355
24CDK41.54973158
25PTK61.54670333
26MTOR1.53856528
27TTK1.47767251
28CAMK1G1.45191060
29RIPK11.42435365
30MKNK21.37688919
31STK31.37649799
32ATR1.35490892
33PRPF4B1.35280182
34CHEK11.33201521
35EIF2AK31.30998535
36NEK11.28146704
37STK101.26216580
38TSSK61.23279866
39TTN1.22442399
40CDK71.16258597
41TAF11.13954810
42FGFR11.13934503
43ATM1.05798614
44STK241.03530800
45MAP3K81.00641717
46CCNB11.00036039
47FGFR30.99536720
48CHEK20.98730860
49PAK20.97883758
50PAK40.95684850
51CDK20.95585575
52SRPK10.95285975
53WEE10.95230341
54SIK20.94923173
55PDGFRB0.94870887
56MST1R0.93767786
57AURKB0.93646587
58ZAK0.93452880
59BMX0.93395606
60LATS20.92810821
61TYRO30.91055137
62BRSK10.89181514
63PLK10.88560361
64FGFR20.88113772
65EPHA20.87674092
66PLK30.87610914
67EIF2AK20.84053015
68TGFBR10.81833531
69MELK0.79525704
70CDK90.78940162
71LRRK20.76656679
72NME20.75866882
73STK40.75499336
74CSNK1D0.73954412
75* CDK10.71385583
76PNCK0.70226204
77ERBB40.69857641
78SIK10.69516161
79DDR20.68408929
80CDK80.67412773
81ERBB30.65864926
82PRKDC0.65594907
83RPS6KA40.63161225
84YES10.62750380
85KSR10.62665950
86AURKA0.61576649
87CSNK1E0.61554151
88ACVR1B0.60684290
89RET0.60671405
90* MAPK140.57050504
91MET0.55545083
92CSNK1A1L0.51335122
93KSR20.51198849
94FLT30.50717628
95EPHB20.50411583
96PIM10.48358795
97CDC42BPA0.48266459
98IRAK30.47488314
99PTK20.47251146
100GSK3B0.47174214
101NEK60.45752196
102DYRK1B0.44891462
103MAP3K70.44007091
104AKT20.44003793
105MAPK10.43954070
106AKT10.43756362
107ERBB20.42339342
108BRSK20.42298266
109MAP4K10.42284895
110NEK90.40543904
111TAOK10.40173664
112MAP3K90.40146770
113GRK60.39467790
114MAPK100.39007908
115BCR0.38063830
116CDK150.38053316
117CDK180.37970386
118BRAF0.37613316
119DYRK30.37589198
120PRKD30.37426897
121CDK11A0.36650120
122DMPK0.36639988
123MAPK80.36425458
124RAF10.36087071
125MAP3K20.35743254
126CHUK0.34685063
127STK390.34417077
128EGFR0.34308488
129CDK30.33107946
130VRK10.32899398
131SGK30.32159676
132RPS6KB10.32086187
133CSNK2A20.31269911
134RPS6KA10.31028710
135CLK10.30371072
136CDK140.30041121
137FGFR40.29870137

Predicted pathways (KEGG)

RankGene SetZ-score
1mRNA surveillance pathway_Homo sapiens_hsa030152.36893058
2Cell cycle_Homo sapiens_hsa041102.33195703
3RNA transport_Homo sapiens_hsa030132.32729704
4Spliceosome_Homo sapiens_hsa030402.19542784
5DNA replication_Homo sapiens_hsa030302.08021160
6One carbon pool by folate_Homo sapiens_hsa006702.07010327
7Mismatch repair_Homo sapiens_hsa034301.99139677
8Lysine degradation_Homo sapiens_hsa003101.95586239
9Chronic myeloid leukemia_Homo sapiens_hsa052201.93216462
10MicroRNAs in cancer_Homo sapiens_hsa052061.86664263
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77756052
12Adherens junction_Homo sapiens_hsa045201.65207418
13mTOR signaling pathway_Homo sapiens_hsa041501.65030721
14Colorectal cancer_Homo sapiens_hsa052101.61809693
15Biosynthesis of amino acids_Homo sapiens_hsa012301.61494544
16Basal cell carcinoma_Homo sapiens_hsa052171.60182524
17Small cell lung cancer_Homo sapiens_hsa052221.56808900
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.49198900
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.48817305
20Endometrial cancer_Homo sapiens_hsa052131.47086349
21Hippo signaling pathway_Homo sapiens_hsa043901.45738280
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42046353
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40891852
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.39767068
25Notch signaling pathway_Homo sapiens_hsa043301.39658090
26Viral carcinogenesis_Homo sapiens_hsa052031.36241546
27Non-small cell lung cancer_Homo sapiens_hsa052231.35169788
28Proteoglycans in cancer_Homo sapiens_hsa052051.32962572
29HTLV-I infection_Homo sapiens_hsa051661.32561214
30Pyrimidine metabolism_Homo sapiens_hsa002401.25881175
31Viral myocarditis_Homo sapiens_hsa054161.25849405
32p53 signaling pathway_Homo sapiens_hsa041151.24068492
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23086849
34Base excision repair_Homo sapiens_hsa034101.21582594
35Non-homologous end-joining_Homo sapiens_hsa034501.21140367
36Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19601994
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.18935480
38Pancreatic cancer_Homo sapiens_hsa052121.18866728
39Fanconi anemia pathway_Homo sapiens_hsa034601.18119291
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17971371
41Prostate cancer_Homo sapiens_hsa052151.16271909
42TGF-beta signaling pathway_Homo sapiens_hsa043501.15754131
43Thyroid cancer_Homo sapiens_hsa052161.14060506
44Glioma_Homo sapiens_hsa052141.13452539
45Antigen processing and presentation_Homo sapiens_hsa046121.09410065
46Pentose phosphate pathway_Homo sapiens_hsa000301.08678979
47Hedgehog signaling pathway_Homo sapiens_hsa043401.08646675
48Nucleotide excision repair_Homo sapiens_hsa034201.07591952
49Oocyte meiosis_Homo sapiens_hsa041141.07586894
50Dorso-ventral axis formation_Homo sapiens_hsa043201.06121061
51Bladder cancer_Homo sapiens_hsa052191.05464636
52Neurotrophin signaling pathway_Homo sapiens_hsa047221.02136411
53RNA degradation_Homo sapiens_hsa030181.01872053
54Focal adhesion_Homo sapiens_hsa045100.99869395
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99543913
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99120634
57Carbon metabolism_Homo sapiens_hsa012000.97019785
58Wnt signaling pathway_Homo sapiens_hsa043100.96359534
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.94774071
60Herpes simplex infection_Homo sapiens_hsa051680.94615300
61RNA polymerase_Homo sapiens_hsa030200.93433854
62Hepatitis B_Homo sapiens_hsa051610.92730697
63Acute myeloid leukemia_Homo sapiens_hsa052210.92566769
64Pathways in cancer_Homo sapiens_hsa052000.91695790
65Renal cell carcinoma_Homo sapiens_hsa052110.90691073
66B cell receptor signaling pathway_Homo sapiens_hsa046620.90673178
67Basal transcription factors_Homo sapiens_hsa030220.90398783
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90108639
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89456049
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85288748
71FoxO signaling pathway_Homo sapiens_hsa040680.84173194
72T cell receptor signaling pathway_Homo sapiens_hsa046600.83442557
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81732542
74Systemic lupus erythematosus_Homo sapiens_hsa053220.80047150
75Epstein-Barr virus infection_Homo sapiens_hsa051690.79816824
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.78095687
77Estrogen signaling pathway_Homo sapiens_hsa049150.76091517
78VEGF signaling pathway_Homo sapiens_hsa043700.75687419
79Tight junction_Homo sapiens_hsa045300.75157328
80Homologous recombination_Homo sapiens_hsa034400.75140985
81Type II diabetes mellitus_Homo sapiens_hsa049300.75140059
82Selenocompound metabolism_Homo sapiens_hsa004500.73533412
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73129617
84ErbB signaling pathway_Homo sapiens_hsa040120.73030459
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72928426
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72507639
87Prolactin signaling pathway_Homo sapiens_hsa049170.72442792
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70835651
89Vitamin B6 metabolism_Homo sapiens_hsa007500.69274520
90Melanoma_Homo sapiens_hsa052180.67470024
91Toxoplasmosis_Homo sapiens_hsa051450.67352641
92Insulin resistance_Homo sapiens_hsa049310.67120569
93AMPK signaling pathway_Homo sapiens_hsa041520.67078696
94Pyruvate metabolism_Homo sapiens_hsa006200.65587858
95ECM-receptor interaction_Homo sapiens_hsa045120.64861730
96Insulin signaling pathway_Homo sapiens_hsa049100.64041083
97N-Glycan biosynthesis_Homo sapiens_hsa005100.64000533
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63626844
99Apoptosis_Homo sapiens_hsa042100.63065867
100HIF-1 signaling pathway_Homo sapiens_hsa040660.61712507
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59552089
102Purine metabolism_Homo sapiens_hsa002300.59271533
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57866774
104Inositol phosphate metabolism_Homo sapiens_hsa005620.56966545
105Steroid biosynthesis_Homo sapiens_hsa001000.56774742
106Proteasome_Homo sapiens_hsa030500.56568184
107Platelet activation_Homo sapiens_hsa046110.53177960
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53108063
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.52658716
110Ribosome_Homo sapiens_hsa030100.52406358
111Rap1 signaling pathway_Homo sapiens_hsa040150.51228414
112Primary immunodeficiency_Homo sapiens_hsa053400.49566716
113Arginine biosynthesis_Homo sapiens_hsa002200.48688193
114Choline metabolism in cancer_Homo sapiens_hsa052310.48426447
115Alcoholism_Homo sapiens_hsa050340.48218045
116Axon guidance_Homo sapiens_hsa043600.47896065
117Amoebiasis_Homo sapiens_hsa051460.47645362
118Melanogenesis_Homo sapiens_hsa049160.45165865
119Influenza A_Homo sapiens_hsa051640.44308635
120Glucagon signaling pathway_Homo sapiens_hsa049220.44202261
121Shigellosis_Homo sapiens_hsa051310.43846033
122Measles_Homo sapiens_hsa051620.43449923
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43434698
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42060663
125Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35706535
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31041636

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