DHX9P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activation of protein kinase A activity (GO:0034199)9.86572793
2negative regulation of type 2 immune response (GO:0002829)9.82752392
3regulation of T-helper 2 cell differentiation (GO:0045628)9.71416707
4positive regulation of RNA splicing (GO:0033120)9.37210665
5seminiferous tubule development (GO:0072520)9.33369783
6negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)9.04335645
7cAMP biosynthetic process (GO:0006171)8.52828960
8detection of chemical stimulus involved in sensory perception (GO:0050907)8.40731841
9negative regulation of alpha-beta T cell differentiation (GO:0046639)8.26424191
10enteric nervous system development (GO:0048484)7.69794466
11regulation of protein sumoylation (GO:0033233)7.15870734
12dendritic spine morphogenesis (GO:0060997)7.00284946
13synaptic transmission, dopaminergic (GO:0001963)6.90147025
14righting reflex (GO:0060013)6.79607381
15positive regulation of mitochondrial fission (GO:0090141)6.74755877
16positive regulation of T-helper 1 type immune response (GO:0002827)6.47122049
17heterotypic cell-cell adhesion (GO:0034113)6.31403799
18detection of chemical stimulus (GO:0009593)6.01030852
19icosanoid secretion (GO:0032309)5.95250759
20arachidonic acid secretion (GO:0050482)5.95250759
21endothelial cell differentiation (GO:0045446)5.86070128
22hepatocyte apoptotic process (GO:0097284)5.82814646
23positive regulation of T-helper cell differentiation (GO:0045624)5.79279617
24phosphatidylinositol acyl-chain remodeling (GO:0036149)5.49585005
25drug transmembrane transport (GO:0006855)5.12891463
26phosphatidylserine acyl-chain remodeling (GO:0036150)5.07333940
27phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.06656161
28regulation of mitochondrial fission (GO:0090140)4.95883385
29fatty acid derivative transport (GO:1901571)4.89206562
30icosanoid transport (GO:0071715)4.89206562
31neuronal ion channel clustering (GO:0045161)4.77383540
32neural tube formation (GO:0001841)4.76780655
33negative regulation of alpha-beta T cell activation (GO:0046636)4.74537136
34regulation of T-helper 1 type immune response (GO:0002825)4.71194260
35chemosensory behavior (GO:0007635)4.70976792
36embryonic digestive tract morphogenesis (GO:0048557)4.57123793
37hyaluronan catabolic process (GO:0030214)4.49073611
38cilium or flagellum-dependent cell motility (GO:0001539)4.44393219
39positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.40583733
40nephron epithelium morphogenesis (GO:0072088)4.30514566
41nephron tubule morphogenesis (GO:0072078)4.30514566
42retina layer formation (GO:0010842)4.25992190
43attachment of spindle microtubules to kinetochore (GO:0008608)4.25139819
44regulation of T-helper cell differentiation (GO:0045622)4.24073732
45vocalization behavior (GO:0071625)4.22761346
46energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.22469470
47ATP hydrolysis coupled proton transport (GO:0015991)4.22469470
48cyclic purine nucleotide metabolic process (GO:0052652)4.21218266
49negative regulation of actin filament bundle assembly (GO:0032232)4.10027050
50cellular response to glucagon stimulus (GO:0071377)4.09308692
51positive regulation of membrane potential (GO:0045838)4.08465651
52cyclic nucleotide biosynthetic process (GO:0009190)4.08151009
53regulation of cAMP-mediated signaling (GO:0043949)4.01984919
54response to dietary excess (GO:0002021)3.99401132
55regulation of type 2 immune response (GO:0002828)3.96595421
56water transport (GO:0006833)3.95708049
57mitochondrial fusion (GO:0008053)3.92743342
58dendritic spine organization (GO:0097061)3.89176048
59positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.88318800
60cAMP metabolic process (GO:0046058)3.86213071
61protein localization to synapse (GO:0035418)3.81000345
62negative regulation of cytosolic calcium ion concentration (GO:0051481)3.71679572
63cytoskeletal anchoring at plasma membrane (GO:0007016)3.66276371
64leukotriene biosynthetic process (GO:0019370)3.65585827
65negative regulation of T cell differentiation (GO:0045581)3.64735796
66phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.59008644
67monoamine transport (GO:0015844)3.54720710
68protein heterotrimerization (GO:0070208)3.54190849
69fluid transport (GO:0042044)3.50884333
70cellular response to ATP (GO:0071318)3.50749074
71cellular zinc ion homeostasis (GO:0006882)3.50183419
72drug transport (GO:0015893)3.47020847
73positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.45430202
74negative regulation of homotypic cell-cell adhesion (GO:0034111)3.42253266
75pre-miRNA processing (GO:0031054)3.38429706
76negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.36542128
77positive regulation of protein targeting to membrane (GO:0090314)3.33644119
78regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.33028860
79sulfur amino acid catabolic process (GO:0000098)3.29764726
80positive regulation of alpha-beta T cell differentiation (GO:0046638)3.24897294
81sequestering of metal ion (GO:0051238)3.21115452
82left/right axis specification (GO:0070986)3.20257162
83regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.13195068
84exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.13002846
85negative regulation of response to reactive oxygen species (GO:1901032)3.11636086
86adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.09882471
87negative regulation of astrocyte differentiation (GO:0048712)3.07304941
88phosphatidylcholine acyl-chain remodeling (GO:0036151)3.06767701
89renal tubule morphogenesis (GO:0061333)3.05075127
90positive regulation of dendritic spine development (GO:0060999)3.04691495
91cellular potassium ion transport (GO:0071804)3.03592531
92potassium ion transmembrane transport (GO:0071805)3.03592531
93response to glucagon (GO:0033762)3.03389303
94tooth mineralization (GO:0034505)13.9184729
95detection of chemical stimulus involved in sensory perception of smell (GO:0050911)13.5214072
96positive regulation of protein sumoylation (GO:0033235)11.4262640
97negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)11.2401745
98negative regulation of T-helper cell differentiation (GO:0045623)11.2401745
99protein K11-linked deubiquitination (GO:0035871)10.4549847
100regulation of T-helper 1 cell differentiation (GO:0045625)10.1265976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.76881042
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.75981660
3AR_21572438_ChIP-Seq_LNCaP_Human4.66202329
4IGF1R_20145208_ChIP-Seq_DFB_Human4.59260596
5VDR_22108803_ChIP-Seq_LS180_Human4.38829447
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.26406474
7EZH2_22144423_ChIP-Seq_EOC_Human3.07388694
8TP53_16413492_ChIP-PET_HCT116_Human2.21689160
9PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.08474801
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse10.0868312
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.97431099
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89643269
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.89643269
14ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.88533511
15YY1_22570637_ChIP-Seq_MALME-3M_Human1.84376589
16DROSHA_22980978_ChIP-Seq_HELA_Human1.76122787
17GATA1_19941826_ChIP-Seq_K562_Human1.72773836
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67030540
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66806690
20EGR1_23403033_ChIP-Seq_LIVER_Mouse1.65807355
21NR3C1_23031785_ChIP-Seq_PC12_Mouse1.63888795
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61594672
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.61341146
24EGR1_19032775_ChIP-ChIP_M12_Human1.60741770
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.55346066
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.50427220
27SMAD3_21741376_ChIP-Seq_EPCs_Human1.45129149
28SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44693557
29SMAD3_21741376_ChIP-Seq_HESCs_Human1.44406258
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44205151
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41775466
32RNF2_27304074_Chip-Seq_NSC_Mouse1.35680069
33ZNF274_21170338_ChIP-Seq_K562_Hela1.32545286
34TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.31043905
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.22674023
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20959768
37RXR_22108803_ChIP-Seq_LS180_Human1.20264215
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.18232834
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17821846
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.17172467
41TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16995872
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16440066
43KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15746150
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14617753
45ER_23166858_ChIP-Seq_MCF-7_Human1.14221153
46SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13789176
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12356064
48PRDM14_20953172_ChIP-Seq_ESCs_Human1.12278481
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.11781080
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.11501386
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10739220
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10305875
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.09699773
54TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08845981
55CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08819699
56HNFA_21074721_ChIP-Seq_CACO-2_Human1.08750902
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07077709
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05849075
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05192915
60TBL1_22424771_ChIP-Seq_293T_Human1.05136620
61STAT3_23295773_ChIP-Seq_U87_Human1.04404559
62SMAD4_21741376_ChIP-Seq_HESCs_Human1.04162145
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03911287
64GATA6_21074721_ChIP-Seq_CACO-2_Human1.02721802
65NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01256163
66GBX2_23144817_ChIP-Seq_PC3_Human1.00228054
67SOX2_18555785_Chip-Seq_ESCs_Mouse0.99090852
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98483915
69CJUN_26792858_Chip-Seq_BT549_Human0.97989922
70PHF8_20622853_ChIP-Seq_HELA_Human0.97605289
71HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97522778
72CMYC_18555785_Chip-Seq_ESCs_Mouse0.96733210
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95795465
74PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.93225106
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92780405
76SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91961146
77TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91675121
78SMAD4_21741376_ChIP-Seq_EPCs_Human0.89976084
79BCAT_22108803_ChIP-Seq_LS180_Human0.89506730
80CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.87794212
81REST_21632747_ChIP-Seq_MESCs_Mouse0.87793136
82TCF4_22108803_ChIP-Seq_LS180_Human0.87420299
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86841961
84CBP_20019798_ChIP-Seq_JUKART_Human0.86555213
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86555213
86SMAD4_21799915_ChIP-Seq_A2780_Human0.85574769
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85216748
88EZH2_27294783_Chip-Seq_NPCs_Mouse0.85185900
89DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84665462
90REST_18959480_ChIP-ChIP_MESCs_Mouse0.83195393
91ETV1_20927104_ChIP-Seq_GIST48_Human0.83036394
92EZH2_18974828_ChIP-Seq_MESCs_Mouse0.81762622
93RNF2_18974828_ChIP-Seq_MESCs_Mouse0.81762622
94E2F1_18555785_Chip-Seq_ESCs_Mouse0.80977217
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80472684
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.80225265
97NANOG_20526341_ChIP-Seq_ESCs_Human0.79757072
98FOXO3_23340844_ChIP-Seq_DLD1_Human0.79428191
99SUZ12_18555785_Chip-Seq_ESCs_Mouse0.78012972
100AR_25329375_ChIP-Seq_VCAP_Human0.77998826

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.48180645
2MP0004130_abnormal_muscle_cell5.01303633
3MP0004264_abnormal_extraembryonic_tissu3.49061857
4MP0003252_abnormal_bile_duct3.36668119
5MP0004133_heterotaxia3.01058311
6MP0002928_abnormal_bile_duct2.73229424
7MP0006072_abnormal_retinal_apoptosis2.43320271
8MP0005448_abnormal_energy_balance2.16672787
9MP0002751_abnormal_autonomic_nervous2.10495970
10MP0001270_distended_abdomen2.04427522
11MP0005084_abnormal_gallbladder_morpholo12.1133896
12MP0005408_hypopigmentation1.97560490
13MP0003646_muscle_fatigue1.95007910
14MP0000566_synostosis1.93009049
15MP0004272_abnormal_basement_membrane1.86381981
16MP0003718_maternal_effect1.85229694
17MP0009764_decreased_sensitivity_to1.72384858
18MP0003329_amyloid_beta_deposits1.66473109
19MP0005220_abnormal_exocrine_pancreas1.59815739
20MP0003943_abnormal_hepatobiliary_system1.53637192
21MP0005379_endocrine/exocrine_gland_phen1.49770955
22MP0002234_abnormal_pharynx_morphology1.36410021
23MP0005645_abnormal_hypothalamus_physiol1.32385258
24MP0001529_abnormal_vocalization1.31861179
25MP0005165_increased_susceptibility_to1.29579375
26MP0000470_abnormal_stomach_morphology1.27307295
27MP0009053_abnormal_anal_canal1.11762253
28MP0001958_emphysema1.05961895
29MP0002572_abnormal_emotion/affect_behav1.03311164
30MP0004043_abnormal_pH_regulation1.03231511
31MP0000604_amyloidosis1.02461738
32MP0001905_abnormal_dopamine_level1.01686839
33MP0005646_abnormal_pituitary_gland1.00183591
34MP0000465_gastrointestinal_hemorrhage0.92760344
35MP0010368_abnormal_lymphatic_system0.92089305
36MP0001501_abnormal_sleep_pattern0.85587028
37MP0008569_lethality_at_weaning0.85154234
38MP0001944_abnormal_pancreas_morphology0.84444150
39MP0005164_abnormal_response_to0.79534034
40MP0003638_abnormal_response/metabolism_0.78858994
41MP0005167_abnormal_blood-brain_barrier0.74220904
42MP0001915_intracranial_hemorrhage0.74010989
43MP0002098_abnormal_vibrissa_morphology0.71195483
44MP0003121_genomic_imprinting0.71053199
45MP0002909_abnormal_adrenal_gland0.66522895
46MP0003283_abnormal_digestive_organ0.66200225
47MP0000609_abnormal_liver_physiology0.65529224
48MP0001800_abnormal_humoral_immune0.63697615
49MP0008469_abnormal_protein_level0.63155816
50MP0002136_abnormal_kidney_physiology0.62782570
51MP0002405_respiratory_system_inflammati0.62212218
52MP0004858_abnormal_nervous_system0.61454649
53MP0005253_abnormal_eye_physiology0.61275457
54MP0005387_immune_system_phenotype0.60183029
55MP0001790_abnormal_immune_system0.60183029
56MP0001533_abnormal_skeleton_physiology0.58690455
57MP0000703_abnormal_thymus_morphology0.57188438
58MP0004484_altered_response_of0.56091299
59MP0003866_abnormal_defecation0.55895021
60MP0000371_diluted_coat_color0.55825543
61MP0004019_abnormal_vitamin_homeostasis0.55564127
62MP0002693_abnormal_pancreas_physiology0.55514418
63MP0003953_abnormal_hormone_level0.51069610
64MP0008875_abnormal_xenobiotic_pharmacok0.50553062
65MP0004233_abnormal_muscle_weight0.50482793
66MP0002078_abnormal_glucose_homeostasis0.50076359
67MP0004084_abnormal_cardiac_muscle0.48937272
68MP0005551_abnormal_eye_electrophysiolog0.46109597
69MP0000477_abnormal_intestine_morphology0.44965126
70MP0003195_calcinosis0.44191492
71MP0001845_abnormal_inflammatory_respons0.43518870
72MP0002998_abnormal_bone_remodeling0.40756038
73MP0008872_abnormal_physiological_respon0.40469800
74MP0001851_eye_inflammation0.39141340
75MP0005423_abnormal_somatic_nervous0.38910804
76MP0009642_abnormal_blood_homeostasis0.38345954
77MP0002396_abnormal_hematopoietic_system0.38042981
78MP0005395_other_phenotype0.37983591
79MP0004947_skin_inflammation0.37679869
80MP0006082_CNS_inflammation0.37208332
81MP0001664_abnormal_digestion0.36628224
82MP0002722_abnormal_immune_system0.36208968
83MP0000759_abnormal_skeletal_muscle0.33887484
84MP0002882_abnormal_neuron_morphology0.33872007
85MP0003315_abnormal_perineum_morphology0.33608519
86MP0005390_skeleton_phenotype0.33379742
87MP0002822_catalepsy0.33113336
88MP0001440_abnormal_grooming_behavior0.32863668
89MP0002113_abnormal_skeleton_development0.32659080
90MP0002429_abnormal_blood_cell0.32551811
91MP0001986_abnormal_taste_sensitivity0.32486992
92MP0005334_abnormal_fat_pad0.32165280
93MP0002109_abnormal_limb_morphology0.29003043
94MP0000598_abnormal_liver_morphology0.28965352
95MP0000163_abnormal_cartilage_morphology0.27551310
96MP0005332_abnormal_amino_acid0.26983696
97MP0002452_abnormal_antigen_presenting0.25706854
98MP0001175_abnormal_lung_morphology0.25607822
99MP0002128_abnormal_blood_circulation0.25323406
100MP0005377_hearing/vestibular/ear_phenot0.25318231

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of calcium-phosphate metabolism (HP:0100530)8.86128990
2Abnormality of dental color (HP:0011073)7.48951121
3Polyuria (HP:0000103)7.36282817
4Abnormality of renal resorption (HP:0011038)7.31290208
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.96769317
6Osteomalacia (HP:0002749)6.91464070
7Abnormality of the dental pulp (HP:0006479)6.75415916
8Abnormal urine output (HP:0012590)6.27091882
9Lip pit (HP:0100267)6.05753508
10Autoimmune thrombocytopenia (HP:0001973)6.05431512
11Abnormality of renal excretion (HP:0011036)5.43499173
12Sparse lateral eyebrow (HP:0005338)5.20610618
13Chronic bronchitis (HP:0004469)4.95490170
14Round ear (HP:0100830)4.93588538
15Depressed nasal tip (HP:0000437)4.86024707
16Intestinal fistula (HP:0100819)4.58426808
17Volvulus (HP:0002580)3.99027500
18Anal stenosis (HP:0002025)3.91525031
19IgM deficiency (HP:0002850)3.84828398
20Ureteral stenosis (HP:0000071)3.83933329
21Short 5th finger (HP:0009237)3.81654119
22Abnormality of the fingertips (HP:0001211)3.80812388
23Toxemia of pregnancy (HP:0100603)3.79629567
24Abnormality of midbrain morphology (HP:0002418)3.68586528
25Molar tooth sign on MRI (HP:0002419)3.68586528
26Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.60257953
27Ureteral obstruction (HP:0006000)3.52661982
28Abnormal respiratory motile cilium physiology (HP:0012261)3.39000601
29Rhinitis (HP:0012384)3.34610282
30Nephrocalcinosis (HP:0000121)3.32912152
31Esophageal varix (HP:0002040)3.16737130
32Tachypnea (HP:0002789)3.02629099
33Ectopic kidney (HP:0000086)2.97941390
34Lipoatrophy (HP:0100578)2.95096422
35Preauricular pit (HP:0004467)2.91751479
36Periauricular skin pits (HP:0100277)2.91751479
37Drooling (HP:0002307)2.86041048
38Thick eyebrow (HP:0000574)2.84439010
39Panhypogammaglobulinemia (HP:0003139)2.76531826
40Nephronophthisis (HP:0000090)2.74171965
41Large earlobe (HP:0009748)2.72824863
42Excessive salivation (HP:0003781)2.72271448
43Hypoparathyroidism (HP:0000829)2.62892770
44Recurrent otitis media (HP:0000403)2.51136947
45Hyperphosphaturia (HP:0003109)2.45501438
46Ectropion (HP:0000656)2.34450638
47Abnormality of transition element cation homeostasis (HP:0011030)2.32743693
48Petechiae (HP:0000967)2.29869020
49Glycosuria (HP:0003076)2.27557408
50Abnormality of urine glucose concentration (HP:0011016)2.27557408
51Hepatitis (HP:0012115)2.21600628
52Personality changes (HP:0000751)2.21093553
53Abnormality of the renal medulla (HP:0100957)2.20028489
54Mask-like facies (HP:0000298)2.18267845
55Dilated cardiomyopathy (HP:0001644)2.09902175
56Inability to walk (HP:0002540)2.09487124
57Chorioretinal coloboma (HP:0000567)2.09217426
58Preauricular skin tag (HP:0000384)2.09138219
59Abnormal delayed hypersensitivity skin test (HP:0002963)2.06193836
60Abnormal urine phosphate concentration (HP:0012599)2.06044510
61Bronchitis (HP:0012387)2.01214201
62Recurrent cutaneous fungal infections (HP:0011370)2.00928624
63Chronic mucocutaneous candidiasis (HP:0002728)2.00928624
64Gingival overgrowth (HP:0000212)2.00424898
65Overgrowth (HP:0001548)10.8022407
66Amelogenesis imperfecta (HP:0000705)10.5332843
67Nephropathy (HP:0000112)1.99491803
68Delayed eruption of teeth (HP:0000684)1.87920034
69Skin pits (HP:0100276)1.87400461
70Agammaglobulinemia (HP:0004432)1.85130882
71Hypercalciuria (HP:0002150)1.81551407
72Striae distensae (HP:0001065)1.76761793
73Long palpebral fissure (HP:0000637)1.75201022
74Highly arched eyebrow (HP:0002553)1.74180826
75Popliteal pterygium (HP:0009756)1.74123852
76Decreased muscle mass (HP:0003199)1.73557339
77Sudden cardiac death (HP:0001645)1.72890796
78Skin tags (HP:0010609)1.72539434
79Abnormality of salivation (HP:0100755)1.71441324
80Bronchiectasis (HP:0002110)1.67487065
81Prominent supraorbital ridges (HP:0000336)1.66205049
82Stage 5 chronic kidney disease (HP:0003774)1.63948555
83Colitis (HP:0002583)1.58905458
84Small hand (HP:0200055)1.55716725
85Congenital hip dislocation (HP:0001374)1.49774943
86Oculomotor apraxia (HP:0000657)1.49453115
87Renal tubular dysfunction (HP:0000124)1.49407699
88Chondrocalcinosis (HP:0000934)1.48674476
89Abnormality of Sharpey fibers (HP:0100685)1.45831333
90Intestinal malrotation (HP:0002566)1.43818152
91Short palm (HP:0004279)1.43061723
92Coarctation of aorta (HP:0001680)1.38417996
93Limited elbow extension (HP:0001377)1.37806919
94Prenatal maternal abnormality (HP:0002686)1.37433030
95Truncal ataxia (HP:0002078)1.37297471
96Palmoplantar keratoderma (HP:0000982)1.34624309
97Blepharitis (HP:0000498)1.32658854
98Non-midline cleft lip (HP:0100335)1.30257303
99Congenital diaphragmatic hernia (HP:0000776)1.29624660
100Polyneuropathy (HP:0001271)1.28473782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.10486077
2BLK3.98097971
3STK33.69025757
4RIPK42.68978884
5STK242.37357559
6WNK42.02842784
7NTRK213.5461597
8BMPR21.91124762
9STK391.83017414
10CDC42BPA1.81600984
11CCNB11.46641860
12PINK11.30138157
13MAP3K31.11936983
14ZAK1.09713787
15HIPK20.96158467
16MAP3K20.93897895
17PRKCQ0.93012829
18SRPK10.91601602
19FRK0.73903049
20JAK30.73533926
21INSRR0.72983095
22FGFR10.70884715
23GRK10.66206442
24SYK0.65832996
25OBSCN0.61410694
26SRC0.56880130
27ROCK20.52884732
28WNK10.52788788
29TXK0.52316668
30PRKAA10.52101835
31EEF2K0.51492510
32WNK30.46828814
33MUSK0.45489811
34ADRBK20.45051475
35TIE10.44989117
36PRKACG0.44970271
37ROCK10.44288418
38CAMK10.43392520
39MAP4K20.42179586
40ABL10.38013894
41PRKACA0.36776197
42MAPKAPK50.36616365
43PIK3CG0.35255340
44CHEK20.32529124
45CAMK2A0.32513676
46GRK70.30654728
47PRKACB0.30289240
48MAPK150.27502755
49CAMK40.27303923
50EPHA40.25243358
51PRKCA0.25200302
52RPS6KA60.24171595
53MAPK130.23564243
54PLK10.23305952
55ILK0.23188102
56TEC0.22687148
57CDC70.22062683
58LYN0.21932418
59MATK0.21845572
60ADRBK10.21700941
61PLK40.21339675
62MAPKAPK30.20979865
63KIT0.19502423
64TNK20.18007537
65RPS6KC10.17970521
66RPS6KL10.17970521
67TLK10.17777901
68CSNK1A10.17390190
69HCK0.17216863
70PRKCB0.17043196
71PHKG20.16858921
72PHKG10.16858921
73MAPK140.16812648
74DAPK20.16762950
75GSK3B0.16362772
76BCKDK0.16129023
77ERBB40.15892076
78GRK50.14674199
79EGFR0.14648801
80ACVR1B0.14296895
81RPS6KA30.14045344
82PRKCG0.13774422
83PRKCD0.13357882
84MAPK90.12947641
85TRPM70.12923165
86CDK10.12849126
87OXSR10.11800940
88FYN0.09622697
89BMPR1B0.09619643
90TTK0.09341992
91PKN10.08828443
92PIK3CA0.08566674
93MAP2K60.08400279
94ITK0.08104761
95IGF1R0.07593822
96PRKCE0.07289162
97ERBB20.06858709
98PIM10.05517696
99INSR0.04728548
100TNIK0.04650017

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.37087939
2Sulfur metabolism_Homo sapiens_hsa009203.77019437
3Sulfur relay system_Homo sapiens_hsa041223.69240561
4Ovarian steroidogenesis_Homo sapiens_hsa049133.29311547
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.20622553
6Linoleic acid metabolism_Homo sapiens_hsa005912.94474125
7Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.76859071
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.59963980
9Collecting duct acid secretion_Homo sapiens_hsa049662.49106056
10Bile secretion_Homo sapiens_hsa049762.31693106
11Salivary secretion_Homo sapiens_hsa049702.30319718
12Vibrio cholerae infection_Homo sapiens_hsa051102.22045098
13Gastric acid secretion_Homo sapiens_hsa049712.15580338
14Thyroid hormone synthesis_Homo sapiens_hsa049182.15078733
15Fat digestion and absorption_Homo sapiens_hsa049752.12530713
16Pancreatic secretion_Homo sapiens_hsa049722.11569477
17Circadian entrainment_Homo sapiens_hsa047132.06277045
18Synaptic vesicle cycle_Homo sapiens_hsa047211.94473599
19Cocaine addiction_Homo sapiens_hsa050301.87020581
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85951098
21Taste transduction_Homo sapiens_hsa047421.80058772
22Insulin secretion_Homo sapiens_hsa049111.77137590
23Vascular smooth muscle contraction_Homo sapiens_hsa042701.72843084
24Morphine addiction_Homo sapiens_hsa050321.72549264
25Glutamatergic synapse_Homo sapiens_hsa047241.72113231
26GABAergic synapse_Homo sapiens_hsa047271.69799671
27Dilated cardiomyopathy_Homo sapiens_hsa054141.63916255
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62966806
29Longevity regulating pathway - mammal_Homo sapiens_hsa042111.60139332
30Ether lipid metabolism_Homo sapiens_hsa005651.56234794
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.48867720
32Amphetamine addiction_Homo sapiens_hsa050311.48323291
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46149507
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.45174076
35Gap junction_Homo sapiens_hsa045401.40845556
36Melanogenesis_Homo sapiens_hsa049161.32205963
37GnRH signaling pathway_Homo sapiens_hsa049121.29934304
38Oxytocin signaling pathway_Homo sapiens_hsa049211.25471630
39Arachidonic acid metabolism_Homo sapiens_hsa005901.25042910
40Calcium signaling pathway_Homo sapiens_hsa040201.15168984
41Cholinergic synapse_Homo sapiens_hsa047251.14731888
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08503323
43Platelet activation_Homo sapiens_hsa046111.08287747
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07315868
45Estrogen signaling pathway_Homo sapiens_hsa049150.99677319
46Circadian rhythm_Homo sapiens_hsa047100.91373494
47Pyruvate metabolism_Homo sapiens_hsa006200.79117680
48Dorso-ventral axis formation_Homo sapiens_hsa043200.78959964
49Serotonergic synapse_Homo sapiens_hsa047260.78709027
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77875050
51Oocyte meiosis_Homo sapiens_hsa041140.72691394
52ECM-receptor interaction_Homo sapiens_hsa045120.71769286
53Rheumatoid arthritis_Homo sapiens_hsa053230.65770825
54Chemokine signaling pathway_Homo sapiens_hsa040620.64638771
55RNA degradation_Homo sapiens_hsa030180.59079426
56Dopaminergic synapse_Homo sapiens_hsa047280.53883148
57cAMP signaling pathway_Homo sapiens_hsa040240.47595733
58Alcoholism_Homo sapiens_hsa050340.47356565
59Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40943141
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36989932
61Arginine biosynthesis_Homo sapiens_hsa002200.35352537
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.34907611
63Primary immunodeficiency_Homo sapiens_hsa053400.34652420
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34544273
65Parkinsons disease_Homo sapiens_hsa050120.34293766
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.31020133
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.29472203
68Purine metabolism_Homo sapiens_hsa002300.29417561
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.29329048
70Phototransduction_Homo sapiens_hsa047440.29275039
71Rap1 signaling pathway_Homo sapiens_hsa040150.25393801
72Retinol metabolism_Homo sapiens_hsa008300.23261176
73Hedgehog signaling pathway_Homo sapiens_hsa043400.22755777
74Staphylococcus aureus infection_Homo sapiens_hsa051500.21873436
75Systemic lupus erythematosus_Homo sapiens_hsa053220.19543435
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19508713
77Oxidative phosphorylation_Homo sapiens_hsa001900.17847226
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17383522
79Caffeine metabolism_Homo sapiens_hsa002320.16101052
80Phagosome_Homo sapiens_hsa041450.15940236
81Nitrogen metabolism_Homo sapiens_hsa009100.15404155
82Ras signaling pathway_Homo sapiens_hsa040140.13136782
83Nicotine addiction_Homo sapiens_hsa050330.12668250
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.12254294
85African trypanosomiasis_Homo sapiens_hsa051430.12196781
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.11930783
87Glucagon signaling pathway_Homo sapiens_hsa049220.11657452
88Type I diabetes mellitus_Homo sapiens_hsa049400.11214054
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.11061841
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.11058771
91Tuberculosis_Homo sapiens_hsa051520.09001323
92Renin secretion_Homo sapiens_hsa049240.08307529
93Asthma_Homo sapiens_hsa053100.07354807
94Graft-versus-host disease_Homo sapiens_hsa053320.06699653
95Chemical carcinogenesis_Homo sapiens_hsa052040.05672913
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.04922518
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.04890362
98Prion diseases_Homo sapiens_hsa050200.04696405
99HTLV-I infection_Homo sapiens_hsa051660.04350817
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.02341314

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