DIAPH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.94793953
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.94793953
3positive regulation of gamma-delta T cell activation (GO:0046645)4.65048259
4antigen processing and presentation of endogenous antigen (GO:0019883)4.54058260
5regulation of gamma-delta T cell differentiation (GO:0045586)4.11913715
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.92491250
7regulation of gamma-delta T cell activation (GO:0046643)3.86532729
8regulation of histone H3-K27 methylation (GO:0061085)3.66829468
9positive regulation by symbiont of host defense response (GO:0052509)3.58317612
10modulation by symbiont of host defense response (GO:0052031)3.58317612
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.58317612
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.58317612
13positive regulation by organism of defense response of other organism involved in symbiotic interact3.58317612
14modulation by symbiont of host immune response (GO:0052553)3.58317612
15negative regulation of cell killing (GO:0031342)3.49275830
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.49275830
17positive regulation of histone deacetylation (GO:0031065)3.20418473
18regulation of interleukin-12 biosynthetic process (GO:0045075)3.19106065
19positive regulation of B cell differentiation (GO:0045579)3.19045646
20positive thymic T cell selection (GO:0045059)3.18660606
21antigen processing and presentation via MHC class Ib (GO:0002475)3.14634727
22immunoglobulin mediated immune response (GO:0016064)3.10036261
23leukocyte aggregation (GO:0070486)3.01785810
24nuclear pore organization (GO:0006999)3.01108963
25JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.00281760
26regulation of interferon-beta biosynthetic process (GO:0045357)2.97092591
27histone H3-K36 demethylation (GO:0070544)2.95267848
28regulation of B cell receptor signaling pathway (GO:0050855)2.95198824
29Arp2/3 complex-mediated actin nucleation (GO:0034314)2.93002536
30detection of other organism (GO:0098543)2.92516173
31negative regulation of interleukin-12 production (GO:0032695)2.89926057
32positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.87501734
33detection of bacterium (GO:0016045)2.86691075
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.86494927
35regulation of B cell differentiation (GO:0045577)2.83758441
36pore complex assembly (GO:0046931)2.78353611
37mannose metabolic process (GO:0006013)2.77580391
38regulation of RNA export from nucleus (GO:0046831)2.77303479
39negative thymic T cell selection (GO:0045060)2.76694050
40positive regulation of interferon-alpha production (GO:0032727)2.76584344
41positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.76532053
42negative regulation of erythrocyte differentiation (GO:0045647)2.75860534
43regulation of integrin activation (GO:0033623)2.75755553
44Golgi transport vesicle coating (GO:0048200)2.73857727
45COPI coating of Golgi vesicle (GO:0048205)2.73857727
46protein localization to endosome (GO:0036010)2.72994599
47negative T cell selection (GO:0043383)2.72728509
48response to laminar fluid shear stress (GO:0034616)2.72680866
49thymic T cell selection (GO:0045061)2.72408534
50regulation of cholesterol storage (GO:0010885)2.72399612
51positive regulation of granulocyte differentiation (GO:0030854)2.72274461
52response to muramyl dipeptide (GO:0032495)2.67196571
53cellular extravasation (GO:0045123)2.66898095
54leukocyte cell-cell adhesion (GO:0007159)2.64095364
55regulation of interferon-alpha production (GO:0032647)2.64068208
56mitotic chromosome condensation (GO:0007076)2.64031884
57positive regulation of Cdc42 GTPase activity (GO:0043089)2.63475622
58negative regulation of T cell mediated immunity (GO:0002710)2.63470635
59B cell mediated immunity (GO:0019724)2.62274422
60regulation of nucleobase-containing compound transport (GO:0032239)2.61115520
61tolerance induction (GO:0002507)2.57663483
62macrophage activation involved in immune response (GO:0002281)2.57016192
63negative regulation of phagocytosis (GO:0050765)2.56887595
64hepatocyte apoptotic process (GO:0097284)2.56081037
65interferon-gamma production (GO:0032609)2.55139725
66DNA unwinding involved in DNA replication (GO:0006268)2.54633750
67positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.54325925
68regulation of type I interferon-mediated signaling pathway (GO:0060338)2.53295228
69negative regulation of lymphocyte mediated immunity (GO:0002707)2.52918841
70response to peptidoglycan (GO:0032494)2.50344167
71regulation of leukocyte degranulation (GO:0043300)2.49734741
72pinocytosis (GO:0006907)2.48663663
73positive regulation of protein deacetylation (GO:0090312)2.48603329
74NIK/NF-kappaB signaling (GO:0038061)2.47202079
75regulation of necroptotic process (GO:0060544)2.47074248
76neutrophil activation involved in immune response (GO:0002283)2.46143658
77regulation of defense response to virus by virus (GO:0050690)2.45795842
78response to type I interferon (GO:0034340)2.45344100
79hypotonic response (GO:0006971)2.44387987
80T cell migration (GO:0072678)2.44260407
81pentose-phosphate shunt (GO:0006098)2.43861304
82regulation of hypersensitivity (GO:0002883)2.42619332
83negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.42005998
84definitive hemopoiesis (GO:0060216)2.41774720
85cellular response to interleukin-4 (GO:0071353)2.41123189
86B cell receptor signaling pathway (GO:0050853)2.40458418
87production of molecular mediator involved in inflammatory response (GO:0002532)2.37579168
88T cell selection (GO:0045058)2.37442594
89lipopolysaccharide-mediated signaling pathway (GO:0031663)2.37094931
90protein export from nucleus (GO:0006611)2.37025245
91type I interferon signaling pathway (GO:0060337)2.36793778
92cellular response to type I interferon (GO:0071357)2.36793778
93response to interleukin-15 (GO:0070672)2.36730464
94detection of external biotic stimulus (GO:0098581)2.36647856
95regulation of response to interferon-gamma (GO:0060330)2.36353854
96cell-substrate junction assembly (GO:0007044)2.33835528
97embryonic process involved in female pregnancy (GO:0060136)2.33481460
98myeloid dendritic cell activation (GO:0001773)2.33394823
99regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.33345782
100respiratory burst (GO:0045730)2.32539824
101germinal center formation (GO:0002467)2.31369295
102negative regulation of leukocyte mediated immunity (GO:0002704)2.30954089
103low-density lipoprotein particle clearance (GO:0034383)2.30728917
104megakaryocyte development (GO:0035855)2.29943514
105positive T cell selection (GO:0043368)2.29714848
106regulation of interleukin-2 biosynthetic process (GO:0045076)2.29674864
1073-UTR-mediated mRNA stabilization (GO:0070935)2.29037236
108regulation of myeloid leukocyte mediated immunity (GO:0002886)2.28059733
109neutrophil activation (GO:0042119)2.28031303
110granulocyte activation (GO:0036230)2.27928452
111response to protozoan (GO:0001562)2.27914914
112myeloid dendritic cell differentiation (GO:0043011)2.27723560
113natural killer cell differentiation (GO:0001779)2.26889245
114positive regulation of interferon-beta production (GO:0032728)2.26763643
115focal adhesion assembly (GO:0048041)2.26652595
116cell-substrate adherens junction assembly (GO:0007045)2.26652595
117regulation of mast cell degranulation (GO:0043304)2.26620191
118regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.26590969
119negative regulation of granulocyte differentiation (GO:0030853)2.26382640
120cellular response to interleukin-15 (GO:0071350)2.26365452
121interferon-gamma-mediated signaling pathway (GO:0060333)2.26063169
122negative regulation of stress fiber assembly (GO:0051497)2.25110614
123modulation by virus of host process (GO:0019054)2.24916510
124apoptotic cell clearance (GO:0043277)2.23778633
125regulation of erythrocyte differentiation (GO:0045646)2.23683476
126negative regulation of necroptotic process (GO:0060546)2.23474781
127modulation by symbiont of host cellular process (GO:0044068)2.23440861
128RNA stabilization (GO:0043489)2.23295134
129mRNA stabilization (GO:0048255)2.23295134
130actin nucleation (GO:0045010)2.21493190
131regulation of natural killer cell mediated immunity (GO:0002715)2.21159578
132regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.21159578
133response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.20095917
134response to host (GO:0075136)2.20095917
135response to host defenses (GO:0052200)2.20095917
136activation of Rac GTPase activity (GO:0032863)2.19375491
137cellular response to epidermal growth factor stimulus (GO:0071364)2.19263541
138T cell apoptotic process (GO:0070231)2.19214730
139response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.19133832
140response to host immune response (GO:0052572)2.19133832
141positive regulation of keratinocyte differentiation (GO:0045618)2.19017367
142regulation of superoxide anion generation (GO:0032928)2.18240709
143nuclear pore complex assembly (GO:0051292)2.17592832
144regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.16847171
145response to fungus (GO:0009620)2.16800462
146positive regulation of isotype switching (GO:0045830)2.16074744

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.17879614
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.68370507
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.25627800
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.06201770
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.04410447
6MYC_22102868_ChIP-Seq_BL_Human3.02407787
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.89560755
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.63303414
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.50978635
10VDR_21846776_ChIP-Seq_THP-1_Human2.49502786
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.46720142
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.45763711
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.29455716
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25327873
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.24346289
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23563782
17TCF7_22412390_ChIP-Seq_EML_Mouse2.21383142
18SCL_19346495_ChIP-Seq_HPC-7_Human2.14871620
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.13624394
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.13414993
21MAF_26560356_Chip-Seq_TH1_Human2.09522572
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.07084324
23BRD4_27068464_Chip-Seq_AML-cells_Mouse2.06851092
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.02303315
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.91836367
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90745429
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.84226056
28MYB_26560356_Chip-Seq_TH2_Human1.82065680
29UTX_26944678_Chip-Seq_JUKART_Human1.79555754
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.79435860
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.77056820
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76137645
33MYB_26560356_Chip-Seq_TH1_Human1.75894901
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75523012
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74414135
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.72131443
37VDR_24763502_ChIP-Seq_THP-1_Human1.71360363
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.69566591
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.67240086
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.65768651
41PPARA_22158963_ChIP-Seq_LIVER_Mouse1.65692131
42KDM2B_26808549_Chip-Seq_DND41_Human1.65630952
43SPI1_23547873_ChIP-Seq_NB4_Human1.60015516
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57291122
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57148569
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51878769
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50574115
48* RUNX_20019798_ChIP-Seq_JUKART_Human1.48832408
49RXR_22158963_ChIP-Seq_LIVER_Mouse1.46785057
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44610554
51SPI1_23127762_ChIP-Seq_K562_Human1.42196554
52EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39336441
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36274129
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36065331
55MAF_26560356_Chip-Seq_TH2_Human1.33551913
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33172057
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30913652
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29628117
59NCOR1_26117541_ChIP-Seq_K562_Human1.27119372
60CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25525064
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25386382
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24643505
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22156911
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18992076
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18356832
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18282612
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17893489
68LXR_22292898_ChIP-Seq_THP-1_Human1.17148439
69LXR_22158963_ChIP-Seq_LIVER_Mouse1.16611262
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14808701
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14495380
72RACK7_27058665_Chip-Seq_MCF-7_Human1.12450050
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12123140
74CIITA_25753668_ChIP-Seq_RAJI_Human1.11914900
75PU_27001747_Chip-Seq_BMDM_Mouse1.11211423
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10234265
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08534900
78CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06604225
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.02922720
80TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02647186
81SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02554053
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02554053
83ATF3_27146783_Chip-Seq_COLON_Human1.02521320
84SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02119377
85GATA3_27048872_Chip-Seq_THYMUS_Human1.01896605
86HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.01479479
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01152957
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00916422
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00856235
90GATA1_22025678_ChIP-Seq_K562_Human1.00732600
91GATA6_25053715_ChIP-Seq_YYC3_Human1.00123367
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99538727
93SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99537175
94ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99440493
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99253600
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98296556
97SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97959897
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97719324
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97510955
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97384168
101RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96073079
102CLOCK_20551151_ChIP-Seq_293T_Human0.95817627
103FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95691913
104* KDM2B_26808549_Chip-Seq_JURKAT_Human0.93790012
105FOXO3_23340844_ChIP-Seq_DLD1_Human0.92836039
106FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.91700923
107TFEB_21752829_ChIP-Seq_HELA_Human0.91448068
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91219397
109E2F4_17652178_ChIP-ChIP_JURKAT_Human0.89752549
110GATA1_19941826_ChIP-Seq_K562_Human0.89157117
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89133136
112P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85795516
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85122262
114HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84971956
115POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81882887
116PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81571025
117ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81197585
118GATA2_19941826_ChIP-Seq_K562_Human0.79971780
119GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79723424
120ZNF263_19887448_ChIP-Seq_K562_Human0.79720424

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.11434839
2MP0003303_peritoneal_inflammation2.98535723
3MP0003436_decreased_susceptibility_to2.91616877
4MP0001835_abnormal_antigen_presentation2.65475154
5MP0009278_abnormal_bone_marrow2.45807080
6MP0000685_abnormal_immune_system2.40294605
7MP0003300_gastrointestinal_ulcer2.38750129
8MP0010352_gastrointestinal_tract_polyps2.32401091
9MP0001790_abnormal_immune_system2.19913547
10MP0005387_immune_system_phenotype2.19913547
11MP0001800_abnormal_humoral_immune2.18530192
12MP0003705_abnormal_hypodermis_morpholog2.07822568
13MP0005464_abnormal_platelet_physiology2.07065424
14MP0005025_abnormal_response_to2.04111351
15MP0009785_altered_susceptibility_to2.01434897
16MP0005000_abnormal_immune_tolerance2.00077706
17MP0002452_abnormal_antigen_presenting1.98148298
18MP0004947_skin_inflammation1.97541375
19MP0008260_abnormal_autophagy1.96853269
20MP0005397_hematopoietic_system_phenotyp1.96237674
21MP0001545_abnormal_hematopoietic_system1.96237674
22MP0002419_abnormal_innate_immunity1.94285021
23MP0003191_abnormal_cellular_cholesterol1.90354442
24MP0005076_abnormal_cell_differentiation1.88618645
25MP0010155_abnormal_intestine_physiology1.86886173
26MP0002723_abnormal_immune_serum1.86415567
27MP0003566_abnormal_cell_adhesion1.86398089
28MP0008057_abnormal_DNA_replication1.85708634
29MP0002405_respiratory_system_inflammati1.83988729
30MP0005671_abnormal_response_to1.83642959
31MP0009840_abnormal_foam_cell1.83459404
32MP0002396_abnormal_hematopoietic_system1.81863895
33MP0002420_abnormal_adaptive_immunity1.81301238
34MP0001819_abnormal_immune_cell1.81126105
35MP0006082_CNS_inflammation1.80610892
36MP0002398_abnormal_bone_marrow1.73813114
37MP0003763_abnormal_thymus_physiology1.69474960
38MP0002166_altered_tumor_susceptibility1.64681962
39MP0004510_myositis1.62181977
40MP0010307_abnormal_tumor_latency1.60124575
41MP0004808_abnormal_hematopoietic_stem1.59737016
42MP0000716_abnormal_immune_system1.56145920
43MP0000689_abnormal_spleen_morphology1.53781122
44MP0001873_stomach_inflammation1.53630015
45MP0002148_abnormal_hypersensitivity_rea1.53043263
46MP0003724_increased_susceptibility_to1.52196753
47MP0004381_abnormal_hair_follicle1.50910336
48MP0002722_abnormal_immune_system1.50789246
49MP0001853_heart_inflammation1.50430466
50MP0005058_abnormal_lysosome_morphology1.48992737
51MP0001845_abnormal_inflammatory_respons1.48869410
52MP0000465_gastrointestinal_hemorrhage1.48709814
53MP0003448_altered_tumor_morphology1.41426470
54MP0009333_abnormal_splenocyte_physiolog1.39985295
55MP0010234_abnormal_vibrissa_follicle1.38839960
56MP0000490_abnormal_crypts_of1.38136826
57MP0002006_tumorigenesis1.37490470
58MP0002429_abnormal_blood_cell1.37224761
59MP0003091_abnormal_cell_migration1.34279500
60MP0002009_preneoplasia1.34181597
61MP0003111_abnormal_nucleus_morphology1.32915091
62MP0003656_abnormal_erythrocyte_physiolo1.32440250
63MP0002877_abnormal_melanocyte_morpholog1.30523567
64MP0005409_darkened_coat_color1.30002727
65MP0003453_abnormal_keratinocyte_physiol1.29324758
66MP0001533_abnormal_skeleton_physiology1.27682967
67MP0005023_abnormal_wound_healing1.26759444
68MP0001730_embryonic_growth_arrest1.24314008
69MP0000858_altered_metastatic_potential1.23294487
70MP0002254_reproductive_system_inflammat1.21678134
71MP0000703_abnormal_thymus_morphology1.20411543
72MP0005360_urolithiasis1.18747207
73MP0002138_abnormal_hepatobiliary_system1.17223995
74MP0008469_abnormal_protein_level1.16672189
75MP0003172_abnormal_lysosome_physiology1.15953595
76MP0003866_abnormal_defecation1.12827195
77MP0005501_abnormal_skin_physiology1.11117335
78MP0008961_abnormal_basal_metabolism1.09545885
79MP0004264_abnormal_extraembryonic_tissu1.08991251
80MP0004957_abnormal_blastocyst_morpholog1.08084046
81MP0000609_abnormal_liver_physiology1.05970982
82MP0005621_abnormal_cell_physiology1.03729653
83MP0001849_ear_inflammation1.03393827
84MP0000350_abnormal_cell_proliferation1.02268406
85MP0005310_abnormal_salivary_gland1.01802266
86MP0005174_abnormal_tail_pigmentation1.00947310
87MP0000343_altered_response_to1.00442590
88MP0000569_abnormal_digit_pigmentation1.00229619
89MP0004185_abnormal_adipocyte_glucose0.99356290
90MP0002019_abnormal_tumor_incidence0.98837424
91MP0001851_eye_inflammation0.98530662
92MP0001915_intracranial_hemorrhage0.97668722
93MP0010094_abnormal_chromosome_stability0.96691478
94MP0004233_abnormal_muscle_weight0.95910000
95MP0005365_abnormal_bile_salt0.95838993
96MP0003075_altered_response_to0.93238473
97MP0002060_abnormal_skin_morphology0.93184488
98MP0003221_abnormal_cardiomyocyte_apopto0.89204057
99MP0003828_pulmonary_edema0.88762014
100MP0009764_decreased_sensitivity_to0.88640169
101MP0005666_abnormal_adipose_tissue0.88132937
102MP0010329_abnormal_lipoprotein_level0.86374394
103MP0000678_abnormal_parathyroid_gland0.86169485
104MP0002139_abnormal_hepatobiliary_system0.85971531
105MP0005166_decreased_susceptibility_to0.85679701
106MP0009763_increased_sensitivity_to0.84348842
107MP0003693_abnormal_embryo_hatching0.84248942
108MP0000598_abnormal_liver_morphology0.82100980
109MP0003984_embryonic_growth_retardation0.81662793
110MP0002796_impaired_skin_barrier0.80943331
111MP0000313_abnormal_cell_death0.78994408
112MP0001216_abnormal_epidermal_layer0.78924312
113MP0002933_joint_inflammation0.78571340
114MP0002086_abnormal_extraembryonic_tissu0.78337337
115MP0005083_abnormal_biliary_tract0.78282886
116MP0005085_abnormal_gallbladder_physiolo0.74909357
117MP0002998_abnormal_bone_remodeling0.74012426
118MP0000371_diluted_coat_color0.73366507
119MP0009931_abnormal_skin_appearance0.73183031
120MP0005319_abnormal_enzyme/_coenzyme0.73122089
121MP0003077_abnormal_cell_cycle0.73029420
122MP0002132_abnormal_respiratory_system0.72746423
123MP0003252_abnormal_bile_duct0.72165601

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.70037687
2Recurrent abscess formation (HP:0002722)3.92436179
3Recurrent gram-negative bacterial infections (HP:0005420)3.81666045
4Recurrent fungal infections (HP:0002841)3.63380066
5Recurrent bacterial skin infections (HP:0005406)3.63371629
6Pustule (HP:0200039)3.40859228
7Recurrent viral infections (HP:0004429)3.28685560
8Myositis (HP:0100614)3.26910380
9Spontaneous hematomas (HP:0007420)3.11173856
10Interstitial pulmonary disease (HP:0006530)3.10788699
11Nasal polyposis (HP:0100582)3.08900800
12Abnormality of the nasal mucosa (HP:0000433)3.03833500
13Autoimmune thrombocytopenia (HP:0001973)3.01715352
14Abnormal platelet volume (HP:0011876)2.88953148
15Cellulitis (HP:0100658)2.86552401
16Abnormality of macrophages (HP:0004311)2.85525727
17Prolonged bleeding time (HP:0003010)2.83931376
18Orchitis (HP:0100796)2.83043604
19Elevated erythrocyte sedimentation rate (HP:0003565)2.79636391
20Increased IgE level (HP:0003212)2.77250046
21Ankyloglossia (HP:0010296)2.75575042
22Chronic otitis media (HP:0000389)2.74642494
23IgM deficiency (HP:0002850)2.74115948
24Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.71661637
25Gingival bleeding (HP:0000225)2.71388973
26Mediastinal lymphadenopathy (HP:0100721)2.71215565
27Abnormal platelet function (HP:0011869)2.67205929
28Impaired platelet aggregation (HP:0003540)2.67205929
29Periodontitis (HP:0000704)2.65570408
30Myocardial infarction (HP:0001658)2.65441547
31Increased mean platelet volume (HP:0011877)2.58864541
32Epistaxis (HP:0000421)2.58061154
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.55948124
34Abnormality of oral frenula (HP:0000190)2.55676209
35T lymphocytopenia (HP:0005403)2.51793403
36Recurrent skin infections (HP:0001581)2.50867461
37Inflammation of the large intestine (HP:0002037)2.49414277
38Petechiae (HP:0000967)2.47504641
39Abnormality of the fingertips (HP:0001211)2.46793339
40Gastrointestinal inflammation (HP:0004386)2.46519480
41Menorrhagia (HP:0000132)2.43468484
42Increased density of long bones (HP:0006392)2.43435712
43Gingivitis (HP:0000230)2.42384019
44Abnormality of T cell number (HP:0011839)2.41686979
45Viral hepatitis (HP:0006562)2.41628396
46Colitis (HP:0002583)2.39314986
47Thrombocytosis (HP:0001894)2.35929404
48Abnormality of T cells (HP:0002843)2.35527389
49Arterial thrombosis (HP:0004420)2.34982036
50Subacute progressive viral hepatitis (HP:0006572)2.31110202
51Recurrent cutaneous fungal infections (HP:0011370)2.29689083
52Chronic mucocutaneous candidiasis (HP:0002728)2.29689083
53Hematochezia (HP:0002573)2.26941755
54Fatigue (HP:0012378)2.25940037
55Vasculitis (HP:0002633)2.24801519
56Esophageal varix (HP:0002040)2.24284861
57Meningitis (HP:0001287)2.23448015
58Distal lower limb amyotrophy (HP:0008944)2.21227994
59Recurrent bronchitis (HP:0002837)2.21050234
60Retrobulbar optic neuritis (HP:0100654)2.20363626
61Optic neuritis (HP:0100653)2.20363626
62Obstructive lung disease (HP:0006536)2.18579147
63Chronic obstructive pulmonary disease (HP:0006510)2.18579147
64Systemic lupus erythematosus (HP:0002725)2.16593638
65Abnormality of T cell physiology (HP:0011840)2.14440359
66Abnormality of the common coagulation pathway (HP:0010990)2.14390006
67Increased cerebral lipofuscin (HP:0011813)2.14245501
68Chest pain (HP:0100749)2.13821725
69Broad face (HP:0000283)2.13420322
70Urticaria (HP:0001025)2.09954552
71Joint hemorrhage (HP:0005261)2.09109219
72Leukocytosis (HP:0001974)2.08542894
73Slow saccadic eye movements (HP:0000514)2.06732648
74Autoimmune hemolytic anemia (HP:0001890)2.05483245
75Hypochromic anemia (HP:0001931)2.05122403
76Abnormal gallbladder physiology (HP:0012438)2.04767428
77Cholecystitis (HP:0001082)2.04767428
78Increased connective tissue (HP:0009025)2.04707482
79Panhypogammaglobulinemia (HP:0003139)2.02225432
80Metaphyseal cupping (HP:0003021)2.02027244
81Hemorrhage of the eye (HP:0011885)2.01992394
82Micronodular cirrhosis (HP:0001413)2.01706996
83Flat acetabular roof (HP:0003180)2.01636980
84Vacuolated lymphocytes (HP:0001922)2.01614853
85Reticulocytosis (HP:0001923)1.99842728
86Centrally nucleated skeletal muscle fibers (HP:0003687)1.97957174
87Milia (HP:0001056)1.96770381
88Stomatitis (HP:0010280)1.96723259
89Granulocytopenia (HP:0001913)1.96440468
90Osteomyelitis (HP:0002754)1.95693238
91Osteolytic defects of the phalanges of the hand (HP:0009771)1.95425991
92Osteolytic defects of the hand bones (HP:0009699)1.95425991
93Increased serum ferritin (HP:0003281)1.91751250
94Ulnar bowing (HP:0003031)1.89704750
95Hemoptysis (HP:0002105)1.89185527
96Cerebral aneurysm (HP:0004944)1.87637665
97Urinary glycosaminoglycan excretion (HP:0003541)1.86583169
98Mucopolysacchariduria (HP:0008155)1.86583169
99Cheilitis (HP:0100825)1.86418879
100Ulnar deviation of the wrist (HP:0003049)1.86321973
101Skin ulcer (HP:0200042)1.85370249
102Polycythemia (HP:0001901)1.84755915
103Dysmetric saccades (HP:0000641)1.83689610
104Pulmonary infiltrates (HP:0002113)1.82600859
105Purpura (HP:0000979)1.81700315
106Gastrointestinal infarctions (HP:0005244)1.81269373
107Hyperacusis (HP:0010780)1.79639104
108Aplasia/Hypoplasia of the thymus (HP:0010515)1.79408876
109Pulmonary embolism (HP:0002204)1.79370428
110Agammaglobulinemia (HP:0004432)1.78279965
111Abnormality of iron homeostasis (HP:0011031)1.78214317
112Frequent falls (HP:0002359)1.77181832
113Encephalitis (HP:0002383)1.75029179
114Thick nail (HP:0001805)1.74947224
115Verrucae (HP:0200043)1.72552611
116Papilloma (HP:0012740)1.72552611
117Anorexia (HP:0002039)1.71626641
118Abnormality of mucopolysaccharide metabolism (HP:0011020)1.70939037
119Abnormality of polysaccharide metabolism (HP:0011012)1.70939037
120Abnormality of glycosaminoglycan metabolism (HP:0004371)1.70939037
121IgA deficiency (HP:0002720)1.70855628
122Deep venous thrombosis (HP:0002625)1.70853830
123Disproportionate tall stature (HP:0001519)1.70520742
124Poikiloderma (HP:0001029)1.69741911
125Persistence of primary teeth (HP:0006335)1.69302380
126Keratoconjunctivitis sicca (HP:0001097)1.69079296
127Dysostosis multiplex (HP:0000943)1.68365030
128Combined immunodeficiency (HP:0005387)1.67665654
129Hepatitis (HP:0012115)1.66528791
130Polygenic inheritance (HP:0010982)1.66479942
131Seborrheic dermatitis (HP:0001051)1.66229084
132Increased neuronal autofluorescent lipopigment (HP:0002074)1.64343475
133Hypertensive crisis (HP:0100735)1.63725291
134Segmental peripheral demyelination/remyelination (HP:0003481)1.62728365
135Abnormality of nail color (HP:0100643)1.61308951
136Acute myeloid leukemia (HP:0004808)1.61220224
137Distal lower limb muscle weakness (HP:0009053)1.60223323
138Abnormality of the thoracic spine (HP:0100711)1.60136542
139Long palpebral fissure (HP:0000637)1.59373297
140Abnormal blistering of the skin (HP:0008066)1.58728024

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.70934428
2PRPF4B3.44508233
3CDK123.12767621
4EEF2K2.91938792
5SMG12.87600337
6TRIB32.84788839
7ERN12.81783537
8STK102.37502751
9PKN22.37004280
10MAP3K102.34279715
11TYK22.05093121
12MAP2K31.97219759
13JAK31.91149202
14TAOK31.84844848
15GRK61.82174499
16TTN1.68469891
17FGFR41.67365107
18TBK11.64984248
19ZAP701.64582646
20LRRK21.61265365
21MAP3K141.60685104
22KSR21.59683762
23KIT1.57022021
24CSK1.56729664
25EPHB11.51114430
26BLK1.50333908
27BTK1.46780672
28TXK1.46356543
29PTK61.43610872
30RIPK11.42043681
31FGFR31.35746203
32TGFBR21.34550420
33JAK11.32124714
34MST1R1.31076861
35SIK31.30967637
36CDK61.30270801
37PIM11.29867753
38HCK1.21854840
39ITK1.18657099
40RPS6KB21.17156544
41ALK1.16671442
42BMX1.15794023
43RPS6KA41.13385051
44IKBKB1.12081603
45IKBKE1.09606393
46MAP3K31.08011338
47CDK41.06666815
48TAOK11.05919369
49CAMK1D1.04577330
50CSF1R1.04368626
51IRAK31.04129824
52JAK21.04108248
53MATK1.02300210
54SYK1.00833271
55MAP3K20.99645561
56IRAK40.99114490
57SIK10.98201454
58RIPK40.96620165
59MAP3K110.95940533
60CHUK0.94407587
61TAOK20.93195094
62SIK20.91954019
63NEK20.91434388
64EIF2AK10.89991068
65TRPM70.89890105
66LCK0.88650560
67TEC0.86418893
68MAP3K80.86112956
69PAK40.84541241
70FLT30.83041451
71CLK10.81490675
72YES10.79724156
73MAP3K70.76759067
74PDPK10.74464418
75RET0.72399952
76RAF10.71276760
77MTOR0.70744088
78PIM20.70608519
79STK30.70003522
80SCYL20.69458009
81STK40.69407390
82IRAK10.68060168
83FES0.67808195
84MARK30.67021433
85MARK20.66096216
86PDK10.64721821
87SGK30.63290834
88BMPR20.63229651
89NME20.62740547
90LYN0.59741612
91BRD40.59458533
92ICK0.58377403
93CDC42BPA0.58319099
94PASK0.57422047
95TESK20.57223880
96STK240.56700558
97FGR0.55101088
98EGFR0.54593332
99MAPK110.54410529
100MAP3K90.54229166
101EPHA30.53863953
102NEK90.53733543
103CDK90.53522748
104RPS6KA60.53404257
105MAP3K130.52595738
106CAMK1G0.52545301
107PDGFRB0.52433175
108TGFBR10.52333453
109MAPKAPK30.52094467
110KSR10.51438121
111IRAK20.51216076
112PDGFRA0.50836423
113CDK70.50403221
114DMPK0.49892445
115EPHA20.48155599
116MST40.48109976
117RPS6KL10.47319894
118RPS6KC10.47319894
119MAPK120.46989644
120MAPKAPK20.46954502
121RPS6KA10.46014969
122PRKG20.45462631
123HIPK20.44671954
124WNK10.43154648
125MELK0.42843893
126ARAF0.41812765
127ABL10.40552518
128MAP3K60.39814034
129MAP2K20.38573577
130MAP3K10.38371647

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.60787020
2Staphylococcus aureus infection_Homo sapiens_hsa051502.44139752
3Osteoclast differentiation_Homo sapiens_hsa043802.09060545
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.07704077
5B cell receptor signaling pathway_Homo sapiens_hsa046622.06617844
6Primary immunodeficiency_Homo sapiens_hsa053402.00510021
7Antigen processing and presentation_Homo sapiens_hsa046121.91810822
8Acute myeloid leukemia_Homo sapiens_hsa052211.72604758
9Measles_Homo sapiens_hsa051621.71081598
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68281693
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58618302
12Toxoplasmosis_Homo sapiens_hsa051451.56150242
13Renal cell carcinoma_Homo sapiens_hsa052111.56124267
14Legionellosis_Homo sapiens_hsa051341.55877249
15Chronic myeloid leukemia_Homo sapiens_hsa052201.54677721
16Hematopoietic cell lineage_Homo sapiens_hsa046401.52829003
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.48972451
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47772574
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47449743
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46591009
21Endometrial cancer_Homo sapiens_hsa052131.46169919
22Caffeine metabolism_Homo sapiens_hsa002321.44546224
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.41482624
24Tuberculosis_Homo sapiens_hsa051521.40412650
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.39884900
26Apoptosis_Homo sapiens_hsa042101.39520380
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39008179
28T cell receptor signaling pathway_Homo sapiens_hsa046601.38918910
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37315933
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.36601868
31Herpes simplex infection_Homo sapiens_hsa051681.36052951
32Pertussis_Homo sapiens_hsa051331.35116679
33Influenza A_Homo sapiens_hsa051641.34343276
34TNF signaling pathway_Homo sapiens_hsa046681.31980036
35Complement and coagulation cascades_Homo sapiens_hsa046101.24214236
36Hepatitis B_Homo sapiens_hsa051611.21041014
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.20757234
38Prostate cancer_Homo sapiens_hsa052151.19736966
39Malaria_Homo sapiens_hsa051441.13903410
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12456491
41Platelet activation_Homo sapiens_hsa046111.11626349
42Viral myocarditis_Homo sapiens_hsa054161.07129922
43Small cell lung cancer_Homo sapiens_hsa052221.05542081
44* Shigellosis_Homo sapiens_hsa051311.03875386
45Graft-versus-host disease_Homo sapiens_hsa053321.03168132
46Nitrogen metabolism_Homo sapiens_hsa009101.03014452
47Pancreatic cancer_Homo sapiens_hsa052121.02004025
48Lysine degradation_Homo sapiens_hsa003101.01499284
49Chemokine signaling pathway_Homo sapiens_hsa040621.00448099
50Insulin resistance_Homo sapiens_hsa049310.99439047
51Glioma_Homo sapiens_hsa052140.99256112
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99179568
53ErbB signaling pathway_Homo sapiens_hsa040120.98606176
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98337998
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97432838
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93896174
57Hepatitis C_Homo sapiens_hsa051600.92344383
58Salmonella infection_Homo sapiens_hsa051320.90270600
59Non-small cell lung cancer_Homo sapiens_hsa052230.89052318
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88818313
61* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88400696
62Other glycan degradation_Homo sapiens_hsa005110.88049985
63Prolactin signaling pathway_Homo sapiens_hsa049170.87510622
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86921913
65Insulin signaling pathway_Homo sapiens_hsa049100.86857132
66One carbon pool by folate_Homo sapiens_hsa006700.86605607
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85581990
68Notch signaling pathway_Homo sapiens_hsa043300.85485211
69Inositol phosphate metabolism_Homo sapiens_hsa005620.85454312
70VEGF signaling pathway_Homo sapiens_hsa043700.85430893
71Choline metabolism in cancer_Homo sapiens_hsa052310.85169220
72mTOR signaling pathway_Homo sapiens_hsa041500.84727115
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.82726070
74Lysosome_Homo sapiens_hsa041420.80720540
75Viral carcinogenesis_Homo sapiens_hsa052030.80681008
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.79686565
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79052511
78ABC transporters_Homo sapiens_hsa020100.76639741
79MicroRNAs in cancer_Homo sapiens_hsa052060.76242475
80HTLV-I infection_Homo sapiens_hsa051660.75368977
81Asthma_Homo sapiens_hsa053100.74886632
82Amoebiasis_Homo sapiens_hsa051460.73492043
83Allograft rejection_Homo sapiens_hsa053300.72995361
84Autoimmune thyroid disease_Homo sapiens_hsa053200.72454989
85Cell cycle_Homo sapiens_hsa041100.71353116
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71300974
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71136407
88Proteoglycans in cancer_Homo sapiens_hsa052050.70851820
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.69432306
90Adherens junction_Homo sapiens_hsa045200.69137289
91Arginine biosynthesis_Homo sapiens_hsa002200.68213947
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67786654
93Prion diseases_Homo sapiens_hsa050200.66517806
94Fructose and mannose metabolism_Homo sapiens_hsa000510.65822739
95GnRH signaling pathway_Homo sapiens_hsa049120.65096008
96HIF-1 signaling pathway_Homo sapiens_hsa040660.64960913
97Endocytosis_Homo sapiens_hsa041440.64754288
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64214964
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63199170
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.61887739
101* Focal adhesion_Homo sapiens_hsa045100.61585179
102p53 signaling pathway_Homo sapiens_hsa041150.61162080
103Selenocompound metabolism_Homo sapiens_hsa004500.60725652
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.59776208
105* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59377806
106Epstein-Barr virus infection_Homo sapiens_hsa051690.58133762
107mRNA surveillance pathway_Homo sapiens_hsa030150.57344134
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56783343
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.55648596
110Pentose phosphate pathway_Homo sapiens_hsa000300.54981546
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54911950
112Bladder cancer_Homo sapiens_hsa052190.54627598
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54352922
114FoxO signaling pathway_Homo sapiens_hsa040680.53289758
115Estrogen signaling pathway_Homo sapiens_hsa049150.53195226
116DNA replication_Homo sapiens_hsa030300.53169185
117Colorectal cancer_Homo sapiens_hsa052100.52267808
118Thyroid cancer_Homo sapiens_hsa052160.52232452
119Galactose metabolism_Homo sapiens_hsa000520.52166346
120Renin-angiotensin system_Homo sapiens_hsa046140.52091618
121Starch and sucrose metabolism_Homo sapiens_hsa005000.50486157
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50390100
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47384347
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47174892
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.44398665
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42929555
127Dorso-ventral axis formation_Homo sapiens_hsa043200.42553148
128Base excision repair_Homo sapiens_hsa034100.42118139

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