DIAPH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the diaphanous subfamily of the formin homology family of proteins. This gene may play a role in the development and normal function of the ovaries. Defects in this gene have been linked to premature ovarian failure 2. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact5.58941358
2modulation by symbiont of host immune response (GO:0052553)5.58941358
3positive regulation by symbiont of host defense response (GO:0052509)5.58941358
4modulation by symbiont of host defense response (GO:0052031)5.58941358
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.58941358
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.58941358
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.91155500
8nuclear pore complex assembly (GO:0051292)4.76965865
9positive regulation of SMAD protein import into nucleus (GO:0060391)4.48272725
10regulation of posttranscriptional gene silencing (GO:0060147)4.45952956
11regulation of gene silencing by miRNA (GO:0060964)4.45952956
12regulation of gene silencing by RNA (GO:0060966)4.45952956
13nuclear pore organization (GO:0006999)4.38666379
14positive regulation of cellular amide metabolic process (GO:0034250)4.29677684
15mitotic G2/M transition checkpoint (GO:0044818)4.22870621
16mitotic G2 DNA damage checkpoint (GO:0007095)4.19092521
17microglial cell activation (GO:0001774)4.17278830
18mitotic sister chromatid cohesion (GO:0007064)4.13784766
19macrophage activation involved in immune response (GO:0002281)4.10429311
20neutrophil activation involved in immune response (GO:0002283)4.07756945
21endothelium development (GO:0003158)4.05791698
22negative regulation of DNA repair (GO:0045738)3.96003344
23regulation of interferon-beta biosynthetic process (GO:0045357)3.91685414
24response to host immune response (GO:0052572)3.87498052
25response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.87498052
26pre-miRNA processing (GO:0031054)3.85088349
27response to peptidoglycan (GO:0032494)3.82941095
28positive regulation of interferon-alpha production (GO:0032727)3.73290098
29labyrinthine layer development (GO:0060711)3.58661381
30neutrophil activation (GO:0042119)3.57748153
31response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.55122427
32response to host (GO:0075136)3.55122427
33response to host defenses (GO:0052200)3.55122427
34regulation of interferon-alpha production (GO:0032647)3.52720766
35neutrophil mediated immunity (GO:0002446)3.52087567
36germinal center formation (GO:0002467)3.50179882
37response to muramyl dipeptide (GO:0032495)3.49270483
38response to hydroperoxide (GO:0033194)3.48911723
39I-kappaB phosphorylation (GO:0007252)3.47293635
40regulation of histone H3-K9 methylation (GO:0051570)3.45189598
41pore complex assembly (GO:0046931)3.43940388
42superoxide anion generation (GO:0042554)3.43573708
43granulocyte activation (GO:0036230)3.42369115
44response to X-ray (GO:0010165)3.40134702
45positive regulation of heat generation (GO:0031652)3.37479257
46negative regulation of fibroblast apoptotic process (GO:2000270)3.35274799
47CENP-A containing nucleosome assembly (GO:0034080)3.35254655
48chromatin remodeling at centromere (GO:0031055)3.33531402
49anterior/posterior axis specification, embryo (GO:0008595)3.31396043
50detection of molecule of bacterial origin (GO:0032490)3.31387157
51positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.30293266
52macrophage activation (GO:0042116)3.28409262
53nodal signaling pathway (GO:0038092)3.26154264
54positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.22627200
55regulation of meiosis I (GO:0060631)3.22492326
56cellular extravasation (GO:0045123)3.22334270
57regulation of helicase activity (GO:0051095)3.20230426
58histone exchange (GO:0043486)3.17831433
59negative regulation of DNA-dependent DNA replication (GO:2000104)3.15929219
60monoubiquitinated protein deubiquitination (GO:0035520)3.15437904
61regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.13905598
62regulation of mitotic spindle checkpoint (GO:1903504)3.13905598
63regulation of SMAD protein import into nucleus (GO:0060390)3.12003293
64negative regulation of granulocyte differentiation (GO:0030853)3.10065673
65regulation of B cell receptor signaling pathway (GO:0050855)3.06948299
66positive regulation of gamma-delta T cell activation (GO:0046645)3.06899666
67negative regulation of interleukin-12 production (GO:0032695)3.06315344
68myeloid cell activation involved in immune response (GO:0002275)3.05734884
69respiratory burst (GO:0045730)3.03930453
70negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.99637100
71negative regulation of translation, ncRNA-mediated (GO:0040033)2.99637100
72regulation of translation, ncRNA-mediated (GO:0045974)2.99637100
73positive regulation of interleukin-1 beta secretion (GO:0050718)2.99105223
74regulation of establishment of cell polarity (GO:2000114)2.94284543
75RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.94224719
76positive regulation of antigen processing and presentation (GO:0002579)2.92110634
77regulation of fever generation (GO:0031620)2.91625142
78regulation of mast cell degranulation (GO:0043304)2.90803286
79regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.84433085
80lipopolysaccharide-mediated signaling pathway (GO:0031663)2.83952045
81immunoglobulin mediated immune response (GO:0016064)2.83527163
82positive regulation of toll-like receptor signaling pathway (GO:0034123)2.80544842
83regulation of dendritic cell antigen processing and presentation (GO:0002604)2.80280106
84transcytosis (GO:0045056)2.78223146
85mitotic metaphase plate congression (GO:0007080)2.77073688
86negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.77008245
87negative regulation of cell killing (GO:0031342)2.77008245
88primitive streak formation (GO:0090009)2.76438858
89regulation of mast cell activation involved in immune response (GO:0033006)2.76426100
90glomerular visceral epithelial cell development (GO:0072015)2.76127246
91myeloid leukocyte mediated immunity (GO:0002444)2.75913998
92regulation of chromatin silencing (GO:0031935)2.75586096
93positive regulation of mast cell activation involved in immune response (GO:0033008)2.73924758
94positive regulation of mast cell degranulation (GO:0043306)2.73924758
95regulation of gene silencing (GO:0060968)2.72470402
96phospholipid scrambling (GO:0017121)2.72030745
97regulation of integrin activation (GO:0033623)2.71745505
98positive regulation of interleukin-1 secretion (GO:0050716)2.71642551
99double-strand break repair via nonhomologous end joining (GO:0006303)2.70947727
100non-recombinational repair (GO:0000726)2.70947727
101glomerular epithelial cell development (GO:0072310)2.70256647
102polyketide metabolic process (GO:0030638)2.70165450
103doxorubicin metabolic process (GO:0044598)2.70165450
104daunorubicin metabolic process (GO:0044597)2.70165450
105positive regulation of catenin import into nucleus (GO:0035413)2.69425967
106interkinetic nuclear migration (GO:0022027)2.69336084
107UDP-N-acetylglucosamine metabolic process (GO:0006047)2.67869972
108positive regulation of interferon-beta production (GO:0032728)2.66973819
109histone H3-K4 trimethylation (GO:0080182)2.66403981
110positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.65384590
111regulation of mesoderm development (GO:2000380)2.65195069
112embryonic process involved in female pregnancy (GO:0060136)2.63705673
113negative regulation of lipid storage (GO:0010888)2.63562983
114positive regulation of protein autophosphorylation (GO:0031954)2.62911967
115cellular response to zinc ion (GO:0071294)2.61899639
116regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.61447698
117phagocytosis, engulfment (GO:0006911)2.61267302
118regulation of myeloid leukocyte mediated immunity (GO:0002886)2.61233826
119regulation of mononuclear cell migration (GO:0071675)2.60949179
120regulation of mast cell activation (GO:0033003)2.59854797
121cytokine secretion (GO:0050663)2.59767945
122definitive hemopoiesis (GO:0060216)2.59673933
123bundle of His cell to Purkinje myocyte communication (GO:0086069)2.58831935
124regulation of establishment or maintenance of cell polarity (GO:0032878)2.57720579
125monocyte chemotaxis (GO:0002548)2.57693435
126regulation of interleukin-1 beta secretion (GO:0050706)2.56897238
127leukocyte aggregation (GO:0070486)2.54898807
128regulation of interleukin-8 biosynthetic process (GO:0045414)2.54263707
129IMP metabolic process (GO:0046040)2.54087920
130regulation of heat generation (GO:0031650)2.54052571
131hydrogen peroxide biosynthetic process (GO:0050665)2.53741434
132metaphase plate congression (GO:0051310)2.53450511
133detection of other organism (GO:0098543)2.52998488
134IMP biosynthetic process (GO:0006188)2.52531670
135regulation of mitotic metaphase/anaphase transition (GO:0030071)2.52487428
136regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.52487428
137ncRNA catabolic process (GO:0034661)2.52035271
138regulation of antigen processing and presentation (GO:0002577)2.51893086
139B cell homeostasis (GO:0001782)2.51261243
140lactate metabolic process (GO:0006089)2.50766964
141pinocytosis (GO:0006907)2.50687923
142regulation of leukocyte degranulation (GO:0043300)2.50209086
143protein localization to kinetochore (GO:0034501)2.49436221
144myeloid leukocyte activation (GO:0002274)2.48803131
145G-protein coupled receptor internalization (GO:0002031)2.48789771
146positive regulation of mast cell activation (GO:0033005)2.48674007
147detection of external biotic stimulus (GO:0098581)2.48213679
148response to interferon-alpha (GO:0035455)2.47781943
149positive regulation of glycoprotein biosynthetic process (GO:0010560)2.47384118
150modulation by symbiont of host cellular process (GO:0044068)2.46993693
151regulation of cell fate specification (GO:0042659)2.44993217
152positive regulation of interleukin-1 beta production (GO:0032731)2.44328567
153DNA replication-independent nucleosome assembly (GO:0006336)2.44297776
154DNA replication-independent nucleosome organization (GO:0034724)2.44297776
155positive regulation of natural killer cell differentiation (GO:0032825)2.44289561
156regulation of hypersensitivity (GO:0002883)2.43479753
157regulation of DNA endoreduplication (GO:0032875)2.43287728
158positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.43148802
159N-terminal protein amino acid acetylation (GO:0006474)2.42254918
160synapsis (GO:0007129)2.41355129
161production of molecular mediator involved in inflammatory response (GO:0002532)2.40232001
162sister chromatid cohesion (GO:0007062)2.39423231
163negative regulation of mast cell activation (GO:0033004)2.38787680
164replicative senescence (GO:0090399)2.38628284
165natural killer cell mediated cytotoxicity (GO:0042267)2.38326859
166natural killer cell mediated immunity (GO:0002228)2.38326859
167positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.38225155
168detection of biotic stimulus (GO:0009595)2.38007846
169negative regulation of thymocyte apoptotic process (GO:0070244)2.37879952
170positive regulation of interleukin-12 production (GO:0032735)2.37795390
171negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.37717410
172negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.37717410
173negative regulation of mitotic sister chromatid segregation (GO:0033048)2.37717410
174negative regulation of mitotic sister chromatid separation (GO:2000816)2.37717410
175negative regulation of sister chromatid segregation (GO:0033046)2.37717410
176positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.37166137
177response to type I interferon (GO:0034340)2.36641906
178histone mRNA catabolic process (GO:0071044)2.35710900
179regulation of DNA methylation (GO:0044030)2.34733523
180regulation of mitotic sister chromatid separation (GO:0010965)2.34708224
181regulation of mitotic sister chromatid segregation (GO:0033047)2.34708224
182regulation of sister chromatid segregation (GO:0033045)2.34708224
183interferon-gamma-mediated signaling pathway (GO:0060333)2.34613557
184type I interferon signaling pathway (GO:0060337)2.33987107
185determination of adult lifespan (GO:0008340)2.33906110
186cellular response to ethanol (GO:0071361)2.33590040
187female gonad development (GO:0008585)2.32649282
188lymphangiogenesis (GO:0001946)2.31627191
189protein complex localization (GO:0031503)2.30547569
190ribosome assembly (GO:0042255)2.29905483
191toxin transport (GO:1901998)2.29651338
192positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.28987207
193positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.28987207
194positive regulation of mitotic sister chromatid separation (GO:1901970)2.28987207
195cell migration involved in gastrulation (GO:0042074)2.28830639
196prenylation (GO:0097354)2.28203086

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.29067376
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.26917020
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.12171392
4E2F7_22180533_ChIP-Seq_HELA_Human3.94024484
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.75816436
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.30072547
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.22435915
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.17057842
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.16387786
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.13256440
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.83805519
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.78722944
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48793548
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.47145716
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.46792008
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.39498337
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.21715117
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.03196859
19EWS_26573619_Chip-Seq_HEK293_Human1.98681505
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.94794242
21MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91379062
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.90466190
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89266593
24* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.85994215
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.83820584
26VDR_24787735_ChIP-Seq_THP-1_Human1.78552099
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75870771
28FUS_26573619_Chip-Seq_HEK293_Human1.75316101
29RUNX_20019798_ChIP-Seq_JUKART_Human1.74116419
30SALL4_18804426_ChIP-ChIP_XEN_Mouse1.74108923
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.74042006
32PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.72023525
33ELK1_19687146_ChIP-ChIP_HELA_Human1.69963417
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.68784651
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63928461
36GBX2_23144817_ChIP-Seq_PC3_Human1.63587193
37VDR_22108803_ChIP-Seq_LS180_Human1.61350171
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59424129
39TP53_16413492_ChIP-PET_HCT116_Human1.58930139
40GATA1_22025678_ChIP-Seq_K562_Human1.57123749
41AR_21909140_ChIP-Seq_LNCAP_Human1.55015818
42SCL_19346495_ChIP-Seq_HPC-7_Human1.51910755
43HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.46006598
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43700421
45PU_27001747_Chip-Seq_BMDM_Mouse1.41954795
46* TAF15_26573619_Chip-Seq_HEK293_Human1.39660455
47CDX2_22108803_ChIP-Seq_LS180_Human1.39340000
48SPI1_23127762_ChIP-Seq_K562_Human1.38446531
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38029172
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34357293
51CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30483411
52BCAT_22108803_ChIP-Seq_LS180_Human1.29917282
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.29615209
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29198736
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28167213
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27359076
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25293808
58NANOG_16153702_ChIP-ChIP_HESCs_Human1.23900743
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21633639
60FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21520872
61FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18731028
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18179422
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17280305
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17092223
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17015514
66EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16335284
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16136997
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15403492
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15196087
70CJUN_26792858_Chip-Seq_BT549_Human1.15006990
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14289577
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13759340
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.13615238
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10177055
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10177055
76RXR_22108803_ChIP-Seq_LS180_Human1.09703669
77CBP_20019798_ChIP-Seq_JUKART_Human1.08980763
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08980763
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08606668
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.08586685
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08084962
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08078377
83FLI1_27457419_Chip-Seq_LIVER_Mouse1.07721534
84AHR_22903824_ChIP-Seq_MCF-7_Human1.07142124
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.07120362
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07092501
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06751847
88TCF4_22108803_ChIP-Seq_LS180_Human1.06516065
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06316388
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06265615
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.05093070
92E2F1_21310950_ChIP-Seq_MCF-7_Human1.04660126
93TP63_17297297_ChIP-ChIP_HaCaT_Human1.04615198
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04017938
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04017938
96STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03957002
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03725877
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03589433
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03581253
100WT1_19549856_ChIP-ChIP_CCG9911_Human1.02435768
101TP63_23658742_ChIP-Seq_EP156T_Human1.02355241
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02307129
103NFE2_27457419_Chip-Seq_LIVER_Mouse1.01024319
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00754781
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00292074
106SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00046244
107ER_23166858_ChIP-Seq_MCF-7_Human0.99651215
108EZH2_27294783_Chip-Seq_NPCs_Mouse0.99201263
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99138949
110TP53_18474530_ChIP-ChIP_U2OS_Human0.99003843
111SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98793518
112CMYC_18555785_Chip-Seq_ESCs_Mouse0.98260144
113ARNT_22903824_ChIP-Seq_MCF-7_Human0.98116312
114POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97785743
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97748715
116NANOG_19829295_ChIP-Seq_ESCs_Human0.97704812
117SOX2_19829295_ChIP-Seq_ESCs_Human0.97704812
118TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97622266
119P53_22387025_ChIP-Seq_ESCs_Mouse0.97416676
120PU1_27457419_Chip-Seq_LIVER_Mouse0.97027717
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96578698
122STAT3_18555785_Chip-Seq_ESCs_Mouse0.95100394
123CRX_20693478_ChIP-Seq_RETINA_Mouse0.95006930
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94063352
125TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93432360
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93421468
127OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92549863
128* SMAD4_21799915_ChIP-Seq_A2780_Human0.92272185
129BRD4_25478319_ChIP-Seq_HGPS_Human0.92137015
130* SPI1_23547873_ChIP-Seq_NB4_Human0.91359593
131SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91335619
132CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91171793
133SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91142969
134* STAT3_23295773_ChIP-Seq_U87_Human0.90446288
135MYB_26560356_Chip-Seq_TH1_Human0.90349474
136MYB_26560356_Chip-Seq_TH2_Human0.90201197
137TCF4_18268006_ChIP-ChIP_LS174T_Human0.89767475
138FOXO3_23340844_ChIP-Seq_DLD1_Human0.88997731
139SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88647280
140PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88615589
141OCT4_18555785_Chip-Seq_ESCs_Mouse0.87958103
142NMYC_18555785_Chip-Seq_ESCs_Mouse0.87771469
143FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87695443
144ESR1_21235772_ChIP-Seq_MCF-7_Human0.86944166
145* P300_19829295_ChIP-Seq_ESCs_Human0.86744578
146KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86684963
147KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86684963
148KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86684963
149CDX2_20551321_ChIP-Seq_CACO-2_Human0.85840702
150SMAD3_21741376_ChIP-Seq_HESCs_Human0.85770539
151P300_18555785_Chip-Seq_ESCs_Mouse0.85591340
152CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85007482
153IGF1R_20145208_ChIP-Seq_DFB_Human0.84230920

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.10321184
2MP0010352_gastrointestinal_tract_polyps3.53307246
3MP0001835_abnormal_antigen_presentation3.39124842
4MP0003941_abnormal_skin_development3.23257741
5MP0003890_abnormal_embryonic-extraembry3.04193401
6MP0002419_abnormal_innate_immunity2.92934822
7MP0003436_decreased_susceptibility_to2.82901003
8MP0003172_abnormal_lysosome_physiology2.58916610
9MP0003724_increased_susceptibility_to2.56624209
10MP0009697_abnormal_copulation2.53706891
11MP0002148_abnormal_hypersensitivity_rea2.52456049
12MP0006054_spinal_hemorrhage2.51434690
13MP0004510_myositis2.48884794
14MP0006082_CNS_inflammation2.46610698
15MP0003303_peritoneal_inflammation2.35549710
16MP0005387_immune_system_phenotype2.34487993
17MP0001790_abnormal_immune_system2.34487993
18MP0010368_abnormal_lymphatic_system2.32897213
19MP0009785_altered_susceptibility_to2.26498298
20MP0005000_abnormal_immune_tolerance2.25596531
21MP0005058_abnormal_lysosome_morphology2.23349829
22MP0002452_abnormal_antigen_presenting2.22258170
23MP0005025_abnormal_response_to2.18828645
24MP0002006_tumorigenesis2.10480776
25MP0005464_abnormal_platelet_physiology2.06542407
26MP0001800_abnormal_humoral_immune2.05424862
27MP0002166_altered_tumor_susceptibility2.00920553
28MP0002723_abnormal_immune_serum2.00799120
29MP0009278_abnormal_bone_marrow2.00093356
30MP0003045_fibrosis1.99190300
31MP0005174_abnormal_tail_pigmentation1.98188433
32MP0004957_abnormal_blastocyst_morpholog1.98010527
33MP0003950_abnormal_plasma_membrane1.97659036
34MP0005671_abnormal_response_to1.97617847
35MP0003183_abnormal_peptide_metabolism1.96459792
36MP0003828_pulmonary_edema1.91413632
37MP0000685_abnormal_immune_system1.91051020
38MP0001879_abnormal_lymphatic_vessel1.89541475
39MP0003300_gastrointestinal_ulcer1.86019585
40MP0003195_calcinosis1.85670988
41MP0002998_abnormal_bone_remodeling1.80799874
42MP0001819_abnormal_immune_cell1.78889820
43MP0010094_abnormal_chromosome_stability1.77883547
44MP0004272_abnormal_basement_membrane1.77481883
45MP0002420_abnormal_adaptive_immunity1.75417799
46MP0000015_abnormal_ear_pigmentation1.71894912
47MP0002254_reproductive_system_inflammat1.70903373
48MP0001533_abnormal_skeleton_physiology1.70711760
49MP0009764_decreased_sensitivity_to1.69814071
50MP0003718_maternal_effect1.65782732
51MP0001853_heart_inflammation1.60738188
52MP0004084_abnormal_cardiac_muscle1.58698791
53MP0003448_altered_tumor_morphology1.57779739
54MP0002405_respiratory_system_inflammati1.57570534
55MP0002396_abnormal_hematopoietic_system1.56958239
56MP0002009_preneoplasia1.50693200
57MP0000371_diluted_coat_color1.47241038
58MP0004947_skin_inflammation1.46461186
59MP0003191_abnormal_cellular_cholesterol1.45824066
60MP0008877_abnormal_DNA_methylation1.45423938
61MP0001845_abnormal_inflammatory_respons1.42993159
62MP0000343_altered_response_to1.39435643
63MP0005171_absent_coat_pigmentation1.37636647
64MP0003566_abnormal_cell_adhesion1.36628955
65MP0010234_abnormal_vibrissa_follicle1.36345843
66MP0002277_abnormal_respiratory_mucosa1.36157359
67MP0001545_abnormal_hematopoietic_system1.32892192
68MP0005397_hematopoietic_system_phenotyp1.32892192
69MP0003077_abnormal_cell_cycle1.32341781
70MP0003075_altered_response_to1.32247097
71MP0005380_embryogenesis_phenotype1.31569060
72MP0001672_abnormal_embryogenesis/_devel1.31569060
73MP0010155_abnormal_intestine_physiology1.29879542
74MP0009672_abnormal_birth_weight1.28266494
75MP0003984_embryonic_growth_retardation1.27497216
76MP0001661_extended_life_span1.26654525
77MP0001851_eye_inflammation1.26261776
78MP0002088_abnormal_embryonic_growth/wei1.26097620
79MP0002928_abnormal_bile_duct1.24842659
80MP0005076_abnormal_cell_differentiation1.24041014
81MP0004036_abnormal_muscle_relaxation1.23540553
82MP0000716_abnormal_immune_system1.22519781
83MP0008058_abnormal_DNA_repair1.22302502
84MP0005075_abnormal_melanosome_morpholog1.20909632
85MP0003690_abnormal_glial_cell1.20115215
86MP0008469_abnormal_protein_level1.18965760
87MP0008438_abnormal_cutaneous_collagen1.18286212
88MP0008007_abnormal_cellular_replicative1.18205893
89MP0002086_abnormal_extraembryonic_tissu1.17908009
90MP0005670_abnormal_white_adipose1.17533990
91MP0001730_embryonic_growth_arrest1.16230327
92MP0005395_other_phenotype1.16097823
93MP0003453_abnormal_keratinocyte_physiol1.12998028
94MP0010678_abnormal_skin_adnexa1.12514727
95MP0005257_abnormal_intraocular_pressure1.11964784
96MP0003868_abnormal_feces_composition1.10340932
97MP0002398_abnormal_bone_marrow1.09486219
98MP0000767_abnormal_smooth_muscle1.09393036
99MP0003567_abnormal_fetal_cardiomyocyte1.06836648
100MP0002796_impaired_skin_barrier1.06835319
101MP0005647_abnormal_sex_gland1.05848206
102MP0010307_abnormal_tumor_latency1.05473600
103MP0002084_abnormal_developmental_patter1.04681579
104MP0005310_abnormal_salivary_gland1.04513198
105MP0003693_abnormal_embryo_hatching1.02665209
106MP0005666_abnormal_adipose_tissue1.01916497
107MP0004215_abnormal_myocardial_fiber1.01670635
108MP0004381_abnormal_hair_follicle1.01571191
109MP0003091_abnormal_cell_migration1.00801922
110MP0005390_skeleton_phenotype0.99544466
111MP0003646_muscle_fatigue0.98138761
112MP0000858_altered_metastatic_potential0.97947805
113MP0005167_abnormal_blood-brain_barrier0.96410974
114MP0001873_stomach_inflammation0.94322525
115MP0001293_anophthalmia0.93977043
116MP0002933_joint_inflammation0.93489131
117MP0005164_abnormal_response_to0.92527606
118MP0000689_abnormal_spleen_morphology0.92309418
119MP0004264_abnormal_extraembryonic_tissu0.91836656
120MP0003111_abnormal_nucleus_morphology0.90717922
121MP0002332_abnormal_exercise_endurance0.90611926
122MP0008004_abnormal_stomach_pH0.89861867
123MP0004782_abnormal_surfactant_physiolog0.89750930
124MP0009703_decreased_birth_body0.89552419
125MP0003279_aneurysm0.88925595
126MP0000383_abnormal_hair_follicle0.87374148
127MP0002925_abnormal_cardiovascular_devel0.87224960
128MP0002429_abnormal_blood_cell0.87082063
129MP0002168_other_aberrant_phenotype0.86704308
130MP0004808_abnormal_hematopoietic_stem0.86131484
131MP0000350_abnormal_cell_proliferation0.86084733
132MP0001958_emphysema0.86057795
133MP0001697_abnormal_embryo_size0.85764726
134MP0008057_abnormal_DNA_replication0.83655255
135MP0002722_abnormal_immune_system0.81738077
136MP0003806_abnormal_nucleotide_metabolis0.81476994
137MP0009763_increased_sensitivity_to0.81380795
138MP0005166_decreased_susceptibility_to0.81248073
139MP0010630_abnormal_cardiac_muscle0.80902368
140MP0001666_abnormal_nutrient_absorption0.80199066
141MP0005165_increased_susceptibility_to0.79778942
142MP0003252_abnormal_bile_duct0.78376617
143MP0000249_abnormal_blood_vessel0.78111767
144MP0002060_abnormal_skin_morphology0.77074696
145MP0005023_abnormal_wound_healing0.77038706
146MP0002085_abnormal_embryonic_tissue0.76985774
147MP0002138_abnormal_hepatobiliary_system0.75808259
148MP0000465_gastrointestinal_hemorrhage0.74945742
149MP0008932_abnormal_embryonic_tissue0.73654957
150MP0004484_altered_response_of0.73378109
151MP0002128_abnormal_blood_circulation0.73110691
152MP0005409_darkened_coat_color0.72596766
153MP0003937_abnormal_limbs/digits/tail_de0.72204275
154MP0005266_abnormal_metabolism0.71007655
155MP0003705_abnormal_hypodermis_morpholog0.69660654
156MP0000266_abnormal_heart_morphology0.69492011
157MP0004185_abnormal_adipocyte_glucose0.68666184
158MP0001915_intracranial_hemorrhage0.68344402
159MP0003795_abnormal_bone_structure0.67547469
160MP0000428_abnormal_craniofacial_morphol0.67477807
161MP0001784_abnormal_fluid_regulation0.66749101
162MP0001614_abnormal_blood_vessel0.66312036
163MP0003786_premature_aging0.66172693
164MP0005275_abnormal_skin_tensile0.66158989
165MP0001191_abnormal_skin_condition0.66150894

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.01917518
2Recurrent bacterial skin infections (HP:0005406)5.70005647
3Eczematoid dermatitis (HP:0000976)5.38340308
4Recurrent gram-negative bacterial infections (HP:0005420)4.60148825
5Hypoglycemic seizures (HP:0002173)4.29784768
6Prostate neoplasm (HP:0100787)3.99986237
7Pancreatic islet-cell hyperplasia (HP:0004510)3.94914006
8Embryonal renal neoplasm (HP:0011794)3.85928453
9Nephroblastoma (Wilms tumor) (HP:0002667)3.65401090
10Mediastinal lymphadenopathy (HP:0100721)3.65391044
11Gingivitis (HP:0000230)3.59566171
12Recurrent skin infections (HP:0001581)3.45441024
13Acute myeloid leukemia (HP:0004808)3.42819148
14Abnormality of macrophages (HP:0004311)3.33363833
15Recurrent fungal infections (HP:0002841)3.31397766
16Periodontitis (HP:0000704)3.26150153
17Orchitis (HP:0100796)3.24695163
18Myositis (HP:0100614)3.23628304
19Retrobulbar optic neuritis (HP:0100654)3.16649494
20Optic neuritis (HP:0100653)3.16649494
21Colon cancer (HP:0003003)3.14066450
22Thick nail (HP:0001805)3.12841802
23Biliary tract neoplasm (HP:0100574)3.06243763
24Papillary thyroid carcinoma (HP:0002895)3.05283420
25Spastic diplegia (HP:0001264)3.04912659
26Systemic lupus erythematosus (HP:0002725)3.01158629
27Stomatitis (HP:0010280)2.94998394
28Symptomatic seizures (HP:0011145)2.94710661
29Hyperinsulinemic hypoglycemia (HP:0000825)2.90748385
30Volvulus (HP:0002580)2.89748936
31Rhabdomyosarcoma (HP:0002859)2.87584901
32Chromosomal breakage induced by crosslinking agents (HP:0003221)2.86147135
33Myocardial infarction (HP:0001658)2.86032548
34Absent frontal sinuses (HP:0002688)2.84762731
35Reduced antithrombin III activity (HP:0001976)2.82316738
36Chronic obstructive pulmonary disease (HP:0006510)2.78268481
37Obstructive lung disease (HP:0006536)2.78268481
38Axonal loss (HP:0003447)2.73000202
39Hypoglycemic coma (HP:0001325)2.71012778
40Recurrent cutaneous fungal infections (HP:0011370)2.70508748
41Chronic mucocutaneous candidiasis (HP:0002728)2.70508748
42Supernumerary spleens (HP:0009799)2.70391047
43Abnormality of the nasal septum (HP:0000419)2.70333987
44Elevated erythrocyte sedimentation rate (HP:0003565)2.69495134
45B lymphocytopenia (HP:0010976)2.67708453
46Chromsome breakage (HP:0040012)2.67510562
47Chronic bronchitis (HP:0004469)2.66664396
48Abnormality of the prostate (HP:0008775)2.61234016
49Abnormality of B cell number (HP:0010975)2.61184991
50Stenosis of the external auditory canal (HP:0000402)2.55969868
51Thrombocytosis (HP:0001894)2.51980263
52Hematochezia (HP:0002573)2.51360251
53Abnormality of the vasculature of the conjunctiva (HP:0008054)2.48235023
54Abnormality of chromosome stability (HP:0003220)2.47618226
55Nemaline bodies (HP:0003798)2.44970225
56Urethral obstruction (HP:0000796)2.44060771
57Sensory axonal neuropathy (HP:0003390)2.43223674
58Neoplasm of the small intestine (HP:0100833)2.42786677
59Conjunctival telangiectasia (HP:0000524)2.42141695
60Recurrent viral infections (HP:0004429)2.42068002
61Vasculitis (HP:0002633)2.40453514
62Vacuolated lymphocytes (HP:0001922)2.39603705
63Osteomyelitis (HP:0002754)2.35473465
64Abnormality of the pancreatic islet cells (HP:0006476)2.35161544
65Abnormality of endocrine pancreas physiology (HP:0012093)2.35161544
66Gingival bleeding (HP:0000225)2.33593326
67Gonadotropin excess (HP:0000837)2.33409452
68Abnormality of the frontal sinuses (HP:0002687)2.32719845
69Premature loss of primary teeth (HP:0006323)2.32112836
70Fair hair (HP:0002286)2.31806265
71Abnormality of the fingertips (HP:0001211)2.30812576
72Pustule (HP:0200039)2.29089960
73Recurrent pneumonia (HP:0006532)2.26955390
74Cheilitis (HP:0100825)2.26209416
75Intrahepatic cholestasis (HP:0001406)2.24487948
76Cellulitis (HP:0100658)2.24316515
77Basal ganglia calcification (HP:0002135)2.23301639
78Abnormality of liposaccharide metabolism (HP:0010968)2.22878928
79Abnormality of glycosphingolipid metabolism (HP:0004343)2.22878928
80Abnormality of glycolipid metabolism (HP:0010969)2.22878928
81Portal hypertension (HP:0001409)2.21599850
82Autoimmune thrombocytopenia (HP:0001973)2.18924526
83Pulmonary infiltrates (HP:0002113)2.18754471
84Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.17312108
85Eosinophilia (HP:0001880)2.17027345
86Bone pain (HP:0002653)2.16956775
87T lymphocytopenia (HP:0005403)2.16601340
88Medulloblastoma (HP:0002885)2.16451015
89Arterial thrombosis (HP:0004420)2.16203457
90Facial diplegia (HP:0001349)2.14432690
91Muscle fiber inclusion bodies (HP:0100299)2.14284401
92Leukocytosis (HP:0001974)2.14170151
93Meningitis (HP:0001287)2.13430045
94Increased cerebral lipofuscin (HP:0011813)2.12654435
95Glomerulonephritis (HP:0000099)2.11704122
96Abnormal hair whorl (HP:0010721)2.11569733
97Chronic diarrhea (HP:0002028)2.10793661
98Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.09525996
99Abnormality of the intrinsic pathway (HP:0010989)2.09326598
100Osteolytic defects of the phalanges of the hand (HP:0009771)2.09088766
101Osteolytic defects of the hand bones (HP:0009699)2.09088766
102Malignant gastrointestinal tract tumors (HP:0006749)2.08090233
103Gastrointestinal carcinoma (HP:0002672)2.08090233
104Lip pit (HP:0100267)2.05632708
105Pathologic fracture (HP:0002756)2.05304140
106Nephritis (HP:0000123)2.04547435
107Dyschromatopsia (HP:0007641)2.04215954
108Increased neuronal autofluorescent lipopigment (HP:0002074)2.03647156
109Abnormal biliary tract morphology (HP:0012440)2.01262431
110Clitoromegaly (HP:0000057)2.00335930
111Esophageal varix (HP:0002040)1.98888889
112Abnormality of the hepatic vasculature (HP:0006707)1.98661834
113Cerebral aneurysm (HP:0004944)1.98261993
114Capillary hemangiomas (HP:0005306)1.98250015
115Pulmonary artery stenosis (HP:0004415)1.98134819
116Abnormality of abdominal situs (HP:0011620)1.97459843
117Abdominal situs inversus (HP:0003363)1.97459843
118Abnormality of male internal genitalia (HP:0000022)1.95713734
119Joint hemorrhage (HP:0005261)1.95021388
120Skull defect (HP:0001362)1.94817297
121Spinal cord lesions (HP:0100561)1.94694164
122Syringomyelia (HP:0003396)1.94694164
123Abnormality of the right ventricle (HP:0001707)1.94142012
124Hemoptysis (HP:0002105)1.94110224
125Abnormal spermatogenesis (HP:0008669)1.93842409
126Keratoconjunctivitis sicca (HP:0001097)1.92636188
127Tetraparesis (HP:0002273)1.92172449
128Disinhibition (HP:0000734)1.90076793
129Distal lower limb amyotrophy (HP:0008944)1.90035803
130Amaurosis fugax (HP:0100576)1.89368873
131Clubbing of toes (HP:0100760)1.88152453
132Type I transferrin isoform profile (HP:0003642)1.87507239
133Dysostosis multiplex (HP:0000943)1.87313624
134Abnormal umbilical cord blood vessels (HP:0011403)1.87078641
135Single umbilical artery (HP:0001195)1.87078641
136Abnormality of the fetal cardiovascular system (HP:0010948)1.87078641
137Abnormality of polysaccharide metabolism (HP:0011012)1.86814066
138Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86814066
139Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86814066
140Thyroiditis (HP:0100646)1.85156937
141Keratoconjunctivitis (HP:0001096)1.84955873
142Recurrent lower respiratory tract infections (HP:0002783)1.84744133
143Submucous cleft hard palate (HP:0000176)1.84054274
144Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.83130366
145Azoospermia (HP:0000027)1.82669516
146Aplasia/Hypoplasia of the hallux (HP:0008362)1.81909621
147Abnormality of T cell number (HP:0011839)1.81883485
148Thyroid carcinoma (HP:0002890)1.81427533
149Agnosia (HP:0010524)1.81312617
150Chronic otitis media (HP:0000389)1.81053634
151Neoplasm of the rectum (HP:0100743)1.81039763
152Spondylolisthesis (HP:0003302)1.79072474
153Hepatoblastoma (HP:0002884)1.78350816
154Right ventricular cardiomyopathy (HP:0011663)1.78076808
155Selective tooth agenesis (HP:0001592)1.77842158
156Neoplasm of the colon (HP:0100273)1.77627474
157Hypochromic microcytic anemia (HP:0004840)1.77048418
158Arterial tortuosity (HP:0005116)1.76876653
159Ascites (HP:0001541)1.75964705
160Narrow palate (HP:0000189)1.75959517
161Abnormal lung lobation (HP:0002101)1.75173932
162Neoplasm of the oral cavity (HP:0100649)1.75004541
163Increased IgM level (HP:0003496)1.74974881
164Short hallux (HP:0010109)1.74922139
165Abnormality of the columella (HP:0009929)1.74874979
166Intestinal fistula (HP:0100819)1.73486562
167Spontaneous hematomas (HP:0007420)1.73388295
168Rhinitis (HP:0012384)1.71860687
169Long foot (HP:0001833)1.71611755
170Bronchitis (HP:0012387)1.71060368
171Albinism (HP:0001022)1.70275823
172Fused cervical vertebrae (HP:0002949)1.70126110
173Carpal bone hypoplasia (HP:0001498)1.70011669
174Abnormality of aspartate family amino acid metabolism (HP:0010899)1.69991198
175Urticaria (HP:0001025)1.69436229
176Embryonal neoplasm (HP:0002898)1.69031753
177Neoplasm of the tracheobronchial system (HP:0100552)1.68767899
178Abnormality of the basal ganglia (HP:0002134)1.66563731
179Short middle phalanx of the 5th finger (HP:0004220)1.66491981
180Prolonged bleeding time (HP:0003010)1.66213811
181Urinary glycosaminoglycan excretion (HP:0003541)1.65438142
182Mucopolysacchariduria (HP:0008155)1.65438142
183Hydroxyprolinuria (HP:0003080)1.65265814
184Cone-rod dystrophy (HP:0000548)1.64901790
185Uterine neoplasm (HP:0010784)1.64040875
186Abnormality of the labia minora (HP:0012880)1.63388263
187Acute lymphatic leukemia (HP:0006721)1.62798587
188Aortic aneurysm (HP:0004942)1.62519032
189Muscle fiber splitting (HP:0003555)1.62463439

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.93755544
2RIPK43.51641925
3ACVR1B3.45986106
4IRAK33.21584390
5IRAK42.89916426
6CDK122.75632059
7TGFBR22.74162762
8BRSK22.25875215
9TIE12.22799038
10EIF2AK32.21748655
11PIK3CG2.21125177
12TXK2.17638576
13TTK2.15185788
14BLK2.09252502
15CAMK1D2.06652549
16TYK22.06272657
17MAP3K131.95034933
18MKNK21.92025626
19NLK1.85683277
20JAK11.83272037
21IKBKE1.75625418
22OBSCN1.73603727
23JAK31.73471258
24SIK31.73271984
25PLK41.72938689
26SIK21.72589660
27FGR1.72335649
28CAMK1G1.65872054
29MKNK11.65650617
30MAP3K121.64962240
31GRK71.64702384
32IKBKB1.61734702
33KIT1.58085571
34CSK1.56880132
35TBK11.56060529
36TNIK1.51863221
37STK38L1.51284921
38TAF11.49290035
39TEC1.49014634
40STK241.48068299
41TAOK31.46489744
42MAP4K11.44526893
43TGFBR11.37697873
44YES11.33877899
45HCK1.32032273
46FLT31.30698236
47PLK31.30268871
48CHUK1.26738984
49FGFR31.24147576
50CSF1R1.20328903
51ZAK1.19678619
52BMPR21.19273617
53SCYL21.18219946
54NUAK11.17369785
55INSRR1.16124317
56MYLK1.15719720
57MARK31.15101839
58TRPM71.14741091
59STK101.10997500
60MATK1.08858361
61EIF2AK21.08500152
62ITK1.07842988
63MELK1.05619401
64CDC71.04730025
65CDK61.04460021
66NEK91.03168773
67OXSR11.00483900
68BRD40.99209387
69FRK0.98283529
70FES0.97920888
71MAP3K60.97792554
72MAPK70.97353919
73LYN0.93862565
74SGK30.93501453
75PBK0.91587569
76SRPK10.90266604
77SGK20.89584762
78EPHA30.88096750
79WNK30.84835366
80LCK0.84835055
81ERN10.83116949
82STK390.82259807
83PIM10.79901326
84LATS10.79459895
85SYK0.79200362
86PLK10.78963578
87JAK20.78663745
88CDK190.78445922
89ADRBK20.78270576
90ERBB40.77063914
91PRPF4B0.77003615
92EPHB10.76034008
93CAMK40.75041006
94ATM0.74766745
95ZAP700.74046919
96SIK10.72820623
97TSSK60.72076639
98CLK10.70337668
99STK30.68848734
100CDK90.68469682
101AKT30.67260678
102MAP2K30.66845180
103MET0.66615803
104FER0.66280067
105BUB10.66046152
106EGFR0.65065761
107ERBB30.64787778
108STK40.64200122
109BTK0.63844590
110PRKAA20.63596467
111SGK10.62796722
112RPS6KA40.59500942
113MAPK150.58653335
114PAK40.57448131
115DYRK30.56848718
116TTN0.56664794
117MST40.55787549
118ABL10.55432705
119PNCK0.54384598
120MAP3K100.53488237
121BMX0.53338874
122PLK20.52686503
123PDGFRB0.50911254
124STK160.49774011
125PRKCQ0.49527452
126CHEK20.47739117
127DMPK0.45228795
128IRAK10.44823868
129MOS0.44591543
130DAPK20.44336305
131IGF1R0.44234341
132CASK0.44174376
133PKN10.44148185
134PIK3CA0.43845732
135DDR20.43407998
136PRKD20.42210944
137BMPR1B0.42138103
138RIPK10.40248663
139GRK10.39914472
140WNK10.39755218
141PRKG20.39297065
142PTK60.39199001
143CDK30.39176614
144PRKCD0.38708745
145VRK10.38078230
146FGFR10.37730779
147CHEK10.37653776
148EEF2K0.37115097
149INSR0.36925333
150ATR0.35691152
151MAP3K80.35586117
152PDGFRA0.35347536
153CAMKK20.34388347
154RPS6KB20.33084346
155RPS6KA60.32890281
156KDR0.31816229

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.43912316
2Mismatch repair_Homo sapiens_hsa034303.00475728
3Staphylococcus aureus infection_Homo sapiens_hsa051502.61775525
4Leishmaniasis_Homo sapiens_hsa051402.56422622
5Osteoclast differentiation_Homo sapiens_hsa043802.46224750
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.45218093
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.42732485
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.32112923
9Homologous recombination_Homo sapiens_hsa034402.15505328
10Propanoate metabolism_Homo sapiens_hsa006402.11740601
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.04675632
12Graft-versus-host disease_Homo sapiens_hsa053321.89361614
13DNA replication_Homo sapiens_hsa030301.89029224
14Tuberculosis_Homo sapiens_hsa051521.88871314
15RNA degradation_Homo sapiens_hsa030181.82803774
16Systemic lupus erythematosus_Homo sapiens_hsa053221.79614791
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78793826
18Measles_Homo sapiens_hsa051621.78619451
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.77057401
20TNF signaling pathway_Homo sapiens_hsa046681.73107758
21Basal transcription factors_Homo sapiens_hsa030221.70396209
22Malaria_Homo sapiens_hsa051441.69863527
23Pertussis_Homo sapiens_hsa051331.67052772
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65935741
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.65269636
26B cell receptor signaling pathway_Homo sapiens_hsa046621.63936094
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.61736669
28Influenza A_Homo sapiens_hsa051641.60398920
29Rheumatoid arthritis_Homo sapiens_hsa053231.60164071
30Retinol metabolism_Homo sapiens_hsa008301.55942141
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.54513971
32TGF-beta signaling pathway_Homo sapiens_hsa043501.51341187
33Proteasome_Homo sapiens_hsa030501.50523196
34African trypanosomiasis_Homo sapiens_hsa051431.50516950
35Nucleotide excision repair_Homo sapiens_hsa034201.50252042
36RNA transport_Homo sapiens_hsa030131.48444473
37Legionellosis_Homo sapiens_hsa051341.46334530
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.45764649
39Fatty acid degradation_Homo sapiens_hsa000711.45743400
40Glutathione metabolism_Homo sapiens_hsa004801.42767134
41Starch and sucrose metabolism_Homo sapiens_hsa005001.41278139
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.40463048
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40432585
44Cell cycle_Homo sapiens_hsa041101.39677411
45Toxoplasmosis_Homo sapiens_hsa051451.38139618
46Chemokine signaling pathway_Homo sapiens_hsa040621.34725891
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.33805366
48Allograft rejection_Homo sapiens_hsa053301.32913214
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32749405
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.32667095
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31913083
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29563630
53Hematopoietic cell lineage_Homo sapiens_hsa046401.27488792
54p53 signaling pathway_Homo sapiens_hsa041151.25986725
55Herpes simplex infection_Homo sapiens_hsa051681.24875064
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22449610
57Lysosome_Homo sapiens_hsa041421.21459144
58Fanconi anemia pathway_Homo sapiens_hsa034601.20653503
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20078176
60Salmonella infection_Homo sapiens_hsa051321.16658788
61Phagosome_Homo sapiens_hsa041451.15722374
62Asthma_Homo sapiens_hsa053101.15229008
63Chemical carcinogenesis_Homo sapiens_hsa052041.13267576
64Primary bile acid biosynthesis_Homo sapiens_hsa001201.13029878
65One carbon pool by folate_Homo sapiens_hsa006701.13010775
66Jak-STAT signaling pathway_Homo sapiens_hsa046301.09268561
67Hepatitis B_Homo sapiens_hsa051611.09218208
68Base excision repair_Homo sapiens_hsa034101.06758804
69Steroid hormone biosynthesis_Homo sapiens_hsa001401.06680245
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05970732
71Other glycan degradation_Homo sapiens_hsa005111.05869553
72beta-Alanine metabolism_Homo sapiens_hsa004101.05035261
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01711029
74Complement and coagulation cascades_Homo sapiens_hsa046100.99689194
75Apoptosis_Homo sapiens_hsa042100.99001177
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98979140
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.98817485
78Selenocompound metabolism_Homo sapiens_hsa004500.97696716
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94909316
80Dorso-ventral axis formation_Homo sapiens_hsa043200.94585474
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93918275
82Histidine metabolism_Homo sapiens_hsa003400.93512547
83Renin-angiotensin system_Homo sapiens_hsa046140.93464328
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92299350
85Tryptophan metabolism_Homo sapiens_hsa003800.92078372
86Adherens junction_Homo sapiens_hsa045200.91454650
87Pancreatic cancer_Homo sapiens_hsa052120.90901382
88Tight junction_Homo sapiens_hsa045300.90769699
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90475747
90Small cell lung cancer_Homo sapiens_hsa052220.90126105
91Amoebiasis_Homo sapiens_hsa051460.89326240
92Hepatitis C_Homo sapiens_hsa051600.87300472
93Primary immunodeficiency_Homo sapiens_hsa053400.87280415
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86653689
95Shigellosis_Homo sapiens_hsa051310.86592647
96Pyruvate metabolism_Homo sapiens_hsa006200.85927594
97Acute myeloid leukemia_Homo sapiens_hsa052210.85408309
98Notch signaling pathway_Homo sapiens_hsa043300.84969006
99Chronic myeloid leukemia_Homo sapiens_hsa052200.82574196
100Platelet activation_Homo sapiens_hsa046110.82486832
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.82213265
102T cell receptor signaling pathway_Homo sapiens_hsa046600.81559875
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81412654
104Circadian rhythm_Homo sapiens_hsa047100.81251989
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80380847
106Type II diabetes mellitus_Homo sapiens_hsa049300.79010147
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78686869
108Autoimmune thyroid disease_Homo sapiens_hsa053200.77877333
109* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76858947
110Protein export_Homo sapiens_hsa030600.76446848
111Viral myocarditis_Homo sapiens_hsa054160.75057035
112Lysine degradation_Homo sapiens_hsa003100.74734924
113ABC transporters_Homo sapiens_hsa020100.72765146
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68028869
115mRNA surveillance pathway_Homo sapiens_hsa030150.67607952
116Wnt signaling pathway_Homo sapiens_hsa043100.67307909
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66699105
118Type I diabetes mellitus_Homo sapiens_hsa049400.66134776
119MicroRNAs in cancer_Homo sapiens_hsa052060.65201392
120Vitamin digestion and absorption_Homo sapiens_hsa049770.61778710
121Caffeine metabolism_Homo sapiens_hsa002320.61543626
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.60610005
123Prostate cancer_Homo sapiens_hsa052150.59882757
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.59294861
125Thyroid cancer_Homo sapiens_hsa052160.58234320
126Rap1 signaling pathway_Homo sapiens_hsa040150.58202400
127Inositol phosphate metabolism_Homo sapiens_hsa005620.57091299
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55427317
129Prolactin signaling pathway_Homo sapiens_hsa049170.54093666
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53321579
131Renin secretion_Homo sapiens_hsa049240.53100583
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52725739
133MAPK signaling pathway_Homo sapiens_hsa040100.51858024
134FoxO signaling pathway_Homo sapiens_hsa040680.51093799
135Focal adhesion_Homo sapiens_hsa045100.50600399
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50375206
137Proteoglycans in cancer_Homo sapiens_hsa052050.49980670
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49028558
139Fatty acid biosynthesis_Homo sapiens_hsa000610.48909089
140Oocyte meiosis_Homo sapiens_hsa041140.47687624
141Insulin resistance_Homo sapiens_hsa049310.46967679
142Purine metabolism_Homo sapiens_hsa002300.46910232
143Antigen processing and presentation_Homo sapiens_hsa046120.46478660
144cAMP signaling pathway_Homo sapiens_hsa040240.46031363
145ECM-receptor interaction_Homo sapiens_hsa045120.45235110
146HIF-1 signaling pathway_Homo sapiens_hsa040660.45206915
147Arachidonic acid metabolism_Homo sapiens_hsa005900.44999707
148Melanoma_Homo sapiens_hsa052180.44400970
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.44255499
150Ras signaling pathway_Homo sapiens_hsa040140.44187720
151Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42970145
152Sphingolipid metabolism_Homo sapiens_hsa006000.42816545
153Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42511023
154Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41968636
155Phospholipase D signaling pathway_Homo sapiens_hsa040720.41198597
156Galactose metabolism_Homo sapiens_hsa000520.41068606
157Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40651246
158Choline metabolism in cancer_Homo sapiens_hsa052310.37803754
159Pathways in cancer_Homo sapiens_hsa052000.37360512
160Sulfur metabolism_Homo sapiens_hsa009200.37252872
161RNA polymerase_Homo sapiens_hsa030200.36085332

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