DIAPH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the diaphanous subfamily of the formin family. Members of this family are involved in actin remodeling and regulate cell movement and adhesion. Mutations in this gene are associated with autosomal dominant auditory neuropathy 1. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.01435845
2protein localization to chromosome, centromeric region (GO:0071459)5.36918855
3kinetochore organization (GO:0051383)5.22949329
4mitotic sister chromatid segregation (GO:0000070)5.09217095
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.07336065
6mitotic chromosome condensation (GO:0007076)4.93454125
7sister chromatid segregation (GO:0000819)4.90760250
8mitotic metaphase plate congression (GO:0007080)4.82384307
9nuclear pore complex assembly (GO:0051292)4.63088674
10meiotic chromosome segregation (GO:0045132)4.58177387
11nuclear pore organization (GO:0006999)4.54646762
12DNA unwinding involved in DNA replication (GO:0006268)4.50677752
13metaphase plate congression (GO:0051310)4.50626525
14attachment of spindle microtubules to kinetochore (GO:0008608)4.45317826
15kinetochore assembly (GO:0051382)4.40513865
16positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.37184646
17positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.37184646
18positive regulation of mitotic sister chromatid separation (GO:1901970)4.37184646
19regulation of spindle organization (GO:0090224)4.34540859
20mitotic sister chromatid cohesion (GO:0007064)4.32299356
21CENP-A containing nucleosome assembly (GO:0034080)4.14850181
22regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.12939461
23establishment of chromosome localization (GO:0051303)4.12705776
24chromatin remodeling at centromere (GO:0031055)4.11430905
25positive regulation of chromosome segregation (GO:0051984)4.11085860
26mitotic nuclear envelope disassembly (GO:0007077)4.05515312
27DNA replication initiation (GO:0006270)4.02693954
28regulation of sister chromatid cohesion (GO:0007063)4.01150265
29DNA replication checkpoint (GO:0000076)3.92315280
30establishment of integrated proviral latency (GO:0075713)3.91405947
31DNA strand elongation involved in DNA replication (GO:0006271)3.91338852
32DNA replication-dependent nucleosome assembly (GO:0006335)3.89190192
33DNA replication-dependent nucleosome organization (GO:0034723)3.89190192
34protein localization to chromosome (GO:0034502)3.86827372
35DNA replication-independent nucleosome assembly (GO:0006336)3.83909508
36DNA replication-independent nucleosome organization (GO:0034724)3.83909508
37mitotic recombination (GO:0006312)3.83599730
38regulation of mitotic spindle organization (GO:0060236)3.81464464
39membrane disassembly (GO:0030397)3.76545908
40nuclear envelope disassembly (GO:0051081)3.76545908
41DNA strand elongation (GO:0022616)3.72341422
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.72195757
43telomere maintenance via recombination (GO:0000722)3.71081333
44telomere maintenance via semi-conservative replication (GO:0032201)3.70616898
45pore complex assembly (GO:0046931)3.69808723
46chromatin assembly or disassembly (GO:0006333)3.61913244
47DNA ligation (GO:0006266)3.60105965
48chromosome segregation (GO:0007059)3.59209631
49regulation of DNA endoreduplication (GO:0032875)3.58659952
50protein K6-linked ubiquitination (GO:0085020)3.53319975
51regulation of chromosome segregation (GO:0051983)3.53307519
52proteasome assembly (GO:0043248)3.52986246
53spindle checkpoint (GO:0031577)3.46894705
54histone exchange (GO:0043486)3.46549652
55microtubule depolymerization (GO:0007019)3.46371626
56chromosome condensation (GO:0030261)3.45877447
57regulation of centrosome cycle (GO:0046605)3.45587213
58chromatin assembly (GO:0031497)3.38295591
59DNA geometric change (GO:0032392)3.35468994
60ventricular cardiac muscle cell development (GO:0055015)3.34319208
61regulation of mitotic metaphase/anaphase transition (GO:0030071)3.33798892
62DNA duplex unwinding (GO:0032508)3.32634077
63non-recombinational repair (GO:0000726)3.31318386
64double-strand break repair via nonhomologous end joining (GO:0006303)3.31318386
65anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.30700657
66regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.27250011
67ribosome assembly (GO:0042255)3.25781455
68maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.22218829
69regulation of histone H3-K9 methylation (GO:0051570)3.20312811
70regulation of centriole replication (GO:0046599)3.19128740
71heterochromatin organization (GO:0070828)3.18771882
72regulation of sister chromatid segregation (GO:0033045)3.18590400
73regulation of mitotic sister chromatid separation (GO:0010965)3.18590400
74regulation of mitotic sister chromatid segregation (GO:0033047)3.18590400
75DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.17991042
76telomere maintenance via telomere lengthening (GO:0010833)3.15626559
77DNA topological change (GO:0006265)3.15452928
78spindle assembly checkpoint (GO:0071173)3.13919558
79histone-serine phosphorylation (GO:0035404)3.13677811
80DNA conformation change (GO:0071103)3.11241779
81negative regulation of chromosome segregation (GO:0051985)3.10820278
82DNA packaging (GO:0006323)3.10633001
83regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08887003
84nucleotide-excision repair, DNA gap filling (GO:0006297)3.05722220
85negative regulation of DNA-dependent DNA replication (GO:2000104)3.04399976
86translesion synthesis (GO:0019985)3.04016538
87negative regulation of mitotic sister chromatid separation (GO:2000816)3.01826488
88negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01826488
89negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.01826488
90negative regulation of sister chromatid segregation (GO:0033046)3.01826488
91regulation of centrosome duplication (GO:0010824)2.97511968
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.97428459
93mitotic spindle checkpoint (GO:0071174)2.96966584
94establishment of viral latency (GO:0019043)2.96705266
95replication fork processing (GO:0031297)2.96391563
96purine nucleobase biosynthetic process (GO:0009113)2.95488899
97mitotic spindle assembly checkpoint (GO:0007094)2.94666240
98DNA damage response, signal transduction resulting in transcription (GO:0042772)2.94518146
99nuclear envelope organization (GO:0006998)2.94489573
100negative regulation of mitosis (GO:0045839)2.94432506
101negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94291830
102G1/S transition of mitotic cell cycle (GO:0000082)2.93599661
103cell cycle G1/S phase transition (GO:0044843)2.93599661
104dosage compensation (GO:0007549)2.89733781
105spindle assembly involved in mitosis (GO:0090307)2.89032082
106mitotic G2/M transition checkpoint (GO:0044818)2.88676406
107IMP biosynthetic process (GO:0006188)2.88426730
108mitotic cytokinesis (GO:0000281)2.86655231
109nucleobase biosynthetic process (GO:0046112)2.86054860
110DNA synthesis involved in DNA repair (GO:0000731)2.85485057
111ATP-dependent chromatin remodeling (GO:0043044)2.84646440
112negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.84282312
113regulation of double-strand break repair (GO:2000779)2.82474762
114telomere maintenance (GO:0000723)2.82276490
115folic acid-containing compound biosynthetic process (GO:0009396)2.79285619
116telomere organization (GO:0032200)2.79112402
117mitotic cell cycle (GO:0000278)2.77829311
118chromosome organization (GO:0051276)2.77044425
119spindle assembly (GO:0051225)2.76922650

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human7.03762354
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.82591297
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.24213481
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.24400303
5AR_21909140_ChIP-Seq_LNCAP_Human2.91373730
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.90009434
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.78985489
8E2F1_21310950_ChIP-Seq_MCF-7_Human2.55328122
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34889730
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33517312
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25273571
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17116651
13MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10313885
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08211103
15E2F7_22180533_ChIP-Seq_HELA_Human10.8879830
16MYC_18358816_ChIP-ChIP_MESCs_Mouse1.85660850
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.82418918
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.81922868
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79287262
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74146036
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72307364
22VDR_23849224_ChIP-Seq_CD4+_Human1.70651665
23MYC_22102868_ChIP-Seq_BL_Human1.69937843
24XRN2_22483619_ChIP-Seq_HELA_Human1.67976548
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67380008
26TP63_19390658_ChIP-ChIP_HaCaT_Human1.66535408
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64042532
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.61499576
29ELK1_19687146_ChIP-ChIP_HELA_Human1.61139772
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54719751
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.51967163
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51438854
33SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.50104944
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49990591
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48844952
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43268803
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42237592
38FOXP3_21729870_ChIP-Seq_TREG_Human1.42105686
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37755335
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.36676081
41TTF2_22483619_ChIP-Seq_HELA_Human1.36263952
42DCP1A_22483619_ChIP-Seq_HELA_Human1.35858980
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34714712
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32530576
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31833252
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29667558
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29023521
48* KDM5A_27292631_Chip-Seq_BREAST_Human1.25262507
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24067916
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.23916629
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21016268
52MYC_18940864_ChIP-ChIP_HL60_Human1.18445394
53CIITA_25753668_ChIP-Seq_RAJI_Human1.17937983
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17707602
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17620361
56NANOG_16153702_ChIP-ChIP_HESCs_Human1.17456301
57* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17146921
58* GABP_19822575_ChIP-Seq_HepG2_Human1.15633028
59SOX17_20123909_ChIP-Seq_XEN_Mouse1.14861820
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11871847
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11054233
62* VDR_21846776_ChIP-Seq_THP-1_Human1.10879870
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09417848
64TFEB_21752829_ChIP-Seq_HELA_Human1.09244055
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08868105
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08008739
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07744318
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07118444
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06835722
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06563842
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03660370
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99827838
73ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99799730
74SRF_21415370_ChIP-Seq_HL-1_Mouse0.96695658
75ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96277767
76* EWS_26573619_Chip-Seq_HEK293_Human0.95068245
77CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94686240
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94676415
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94534262
80SPI1_23547873_ChIP-Seq_NB4_Human0.93289581
81MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.91133531
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90900815
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.90836782
84POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90372854
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89362691
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89023406
87SCL_19346495_ChIP-Seq_HPC-7_Human0.87923530
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87735374
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87286007
90* SOX2_16153702_ChIP-ChIP_HESCs_Human0.86020514
91NANOG_21062744_ChIP-ChIP_HESCs_Human0.85884935
92* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85286400
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84544944
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.84190384
95BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82885773
96PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81285458
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81069151
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81062948
99SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80927755
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80670750
101SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.80453882
102BRD4_25478319_ChIP-Seq_HGPS_Human0.80266198
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80044608
104MYB_26560356_Chip-Seq_TH1_Human0.78737597
105TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.76857777
106TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75940671
107EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.75760058
108MYB_26560356_Chip-Seq_TH2_Human0.74250943
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.74186911
110* FUS_26573619_Chip-Seq_HEK293_Human0.74179317
111HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74021868
112SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.73993938
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.73948827
114RBPJ_22232070_ChIP-Seq_NCS_Mouse0.73753333
115ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.72666707
116CHD1_26751641_Chip-Seq_LNCaP_Human0.72517804
117TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.71597121
118NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.70384513
119YY1_21170310_ChIP-Seq_MESCs_Mouse0.68462309
120CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.66714384
121ELK1_22589737_ChIP-Seq_MCF10A_Human0.66263999
122NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.63924432
123WT1_19549856_ChIP-ChIP_CCG9911_Human0.63178042

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.61119770
2MP0003111_abnormal_nucleus_morphology4.33350063
3MP0010094_abnormal_chromosome_stability4.24180081
4MP0008057_abnormal_DNA_replication3.64499303
5MP0003077_abnormal_cell_cycle3.62822584
6MP0004957_abnormal_blastocyst_morpholog3.54959988
7MP0010352_gastrointestinal_tract_polyps2.82497611
8MP0009697_abnormal_copulation2.64917172
9MP0002396_abnormal_hematopoietic_system2.46110281
10MP0010307_abnormal_tumor_latency2.45355035
11MP0008058_abnormal_DNA_repair2.43033511
12MP0008007_abnormal_cellular_replicative2.29496176
13MP0008932_abnormal_embryonic_tissue2.26141221
14MP0000350_abnormal_cell_proliferation2.14252350
15MP0003950_abnormal_plasma_membrane2.05523948
16MP0001730_embryonic_growth_arrest2.00239118
17MP0004808_abnormal_hematopoietic_stem1.97064782
18MP0005076_abnormal_cell_differentiation1.89492355
19MP0003705_abnormal_hypodermis_morpholog1.82171655
20MP0006292_abnormal_olfactory_placode1.82089423
21MP0008877_abnormal_DNA_methylation1.81351281
22MP0005380_embryogenesis_phenotype1.79335005
23MP0001672_abnormal_embryogenesis/_devel1.79335005
24MP0000490_abnormal_crypts_of1.76430103
25MP0003984_embryonic_growth_retardation1.62201067
26MP0001697_abnormal_embryo_size1.62125841
27MP0002086_abnormal_extraembryonic_tissu1.61526013
28MP0002088_abnormal_embryonic_growth/wei1.58740685
29MP0003567_abnormal_fetal_cardiomyocyte1.58242960
30MP0005397_hematopoietic_system_phenotyp1.56995532
31MP0001545_abnormal_hematopoietic_system1.56995532
32MP0002877_abnormal_melanocyte_morpholog1.55318839
33MP0003123_paternal_imprinting1.50975186
34MP0002084_abnormal_developmental_patter1.50772417
35MP0002085_abnormal_embryonic_tissue1.47321670
36MP0004197_abnormal_fetal_growth/weight/1.46765752
37MP0002080_prenatal_lethality1.41283918
38MP0003566_abnormal_cell_adhesion1.40227012
39MP0000569_abnormal_digit_pigmentation1.37382689
40MP0003121_genomic_imprinting1.37133400
41MP0003786_premature_aging1.37086721
42MP0009278_abnormal_bone_marrow1.37001720
43MP0002938_white_spotting1.35251455
44MP0002019_abnormal_tumor_incidence1.32668059
45MP0000313_abnormal_cell_death1.32510589
46MP0000537_abnormal_urethra_morphology1.31390890
47MP0004272_abnormal_basement_membrane1.28988706
48MP0001286_abnormal_eye_development1.27577849
49MP0003806_abnormal_nucleotide_metabolis1.25982171
50MP0010030_abnormal_orbit_morphology1.20601431
51MP0005023_abnormal_wound_healing1.16948646
52MP0001293_anophthalmia1.08646365
53MP0000358_abnormal_cell_content/1.07394403
54MP0002398_abnormal_bone_marrow1.07094826
55MP0003890_abnormal_embryonic-extraembry1.06861625
56MP0006054_spinal_hemorrhage1.05952820
57MP0000703_abnormal_thymus_morphology1.05840021
58MP0003937_abnormal_limbs/digits/tail_de1.05673023
59MP0000733_abnormal_muscle_development1.03447021
60MP0003718_maternal_effect1.01474104
61MP0003385_abnormal_body_wall1.01438172
62MP0000762_abnormal_tongue_morphology1.00309842
63MP0008438_abnormal_cutaneous_collagen1.00160062
64MP0003941_abnormal_skin_development0.99500865
65MP0002722_abnormal_immune_system0.98544147
66MP0001915_intracranial_hemorrhage0.96394778
67MP0002233_abnormal_nose_morphology0.96314392
68MP0001346_abnormal_lacrimal_gland0.95842948
69MP0005621_abnormal_cell_physiology0.95610109
70MP0002234_abnormal_pharynx_morphology0.94688496
71MP0003656_abnormal_erythrocyte_physiolo0.94533779
72MP0004233_abnormal_muscle_weight0.94281222
73MP0004264_abnormal_extraembryonic_tissu0.93936618
74MP0002210_abnormal_sex_determination0.93848187
75MP0009250_abnormal_appendicular_skeleto0.93301213
76MP0005623_abnormal_meninges_morphology0.92855119
77MP0005395_other_phenotype0.90715525
78MP0001299_abnormal_eye_distance/0.89442006
79MP0000689_abnormal_spleen_morphology0.89307880
80MP0000858_altered_metastatic_potential0.88230982
81MP0002160_abnormal_reproductive_system0.87585929
82MP0009333_abnormal_splenocyte_physiolog0.85058588
83MP0000049_abnormal_middle_ear0.84120680
84MP0005384_cellular_phenotype0.83664083
85MP0000647_abnormal_sebaceous_gland0.83399066
86MP0003119_abnormal_digestive_system0.83224697
87MP0000432_abnormal_head_morphology0.83015232
88MP0001661_extended_life_span0.82930307
89MP0001849_ear_inflammation0.80887391
90MP0002925_abnormal_cardiovascular_devel0.79962587
91MP0001145_abnormal_male_reproductive0.79269260
92MP0005408_hypopigmentation0.77022390
93MP0002092_abnormal_eye_morphology0.76860888
94MP0003091_abnormal_cell_migration0.76388998
95MP0003942_abnormal_urinary_system0.76222328
96MP0001929_abnormal_gametogenesis0.75689850
97MP0005501_abnormal_skin_physiology0.74989686
98MP0009703_decreased_birth_body0.74800576
99MP0002429_abnormal_blood_cell0.74677996
100MP0003448_altered_tumor_morphology0.74521553
101MP0002060_abnormal_skin_morphology0.73253524
102MP0002177_abnormal_outer_ear0.72794672
103MP0003115_abnormal_respiratory_system0.72547605
104MP0003943_abnormal_hepatobiliary_system0.72202396
105MP0005171_absent_coat_pigmentation0.72030043
106MP0001881_abnormal_mammary_gland0.71356411
107MP0001119_abnormal_female_reproductive0.71205941
108MP0002111_abnormal_tail_morphology0.70988476
109MP0003763_abnormal_thymus_physiology0.70821120
110MP0003315_abnormal_perineum_morphology0.69915165
111MP0000427_abnormal_hair_cycle0.69656631
112MP0003935_abnormal_craniofacial_develop0.69267297
113MP0005174_abnormal_tail_pigmentation0.68952403
114MP0003300_gastrointestinal_ulcer0.68923032
115MP0004147_increased_porphyrin_level0.68798144
116MP0000428_abnormal_craniofacial_morphol0.68595263
117MP0003787_abnormal_imprinting0.68361941
118MP0000653_abnormal_sex_gland0.68196028
119MP0000383_abnormal_hair_follicle0.67918900
120MP0008770_decreased_survivor_rate0.67592209
121MP0003861_abnormal_nervous_system0.67271776
122MP0005197_abnormal_uvea_morphology0.67144133
123MP0002006_tumorigenesis0.66601573
124MP0009672_abnormal_birth_weight0.65648017
125MP0002009_preneoplasia0.64807255
126MP0000685_abnormal_immune_system0.64787612
127MP0002102_abnormal_ear_morphology0.64109474
128MP0000372_irregular_coat_pigmentation0.63674937
129MP0009053_abnormal_anal_canal0.63527958
130MP0008789_abnormal_olfactory_epithelium0.63040918
131MP0003755_abnormal_palate_morphology0.62848627
132MP0002114_abnormal_axial_skeleton0.62454159
133MP0005257_abnormal_intraocular_pressure0.62340551
134MP0006035_abnormal_mitochondrial_morpho0.61826428
135MP0002697_abnormal_eye_size0.61499277
136MP0000716_abnormal_immune_system0.61499202

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.04297696
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.80370955
3Abnormality of chromosome stability (HP:0003220)3.55065897
4Volvulus (HP:0002580)3.42881821
5Birth length less than 3rd percentile (HP:0003561)3.33871190
6Meckel diverticulum (HP:0002245)3.10140518
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.02993617
8Aplasia/Hypoplasia of the sacrum (HP:0008517)3.01183169
9Ectopic kidney (HP:0000086)2.99366700
10Abnormality of the ileum (HP:0001549)2.97607172
11Abnormality of the preputium (HP:0100587)2.94854321
12Impulsivity (HP:0100710)2.91410767
13Selective tooth agenesis (HP:0001592)2.90790747
14Myelodysplasia (HP:0002863)2.87055877
15Reticulocytopenia (HP:0001896)2.80859326
16Small intestinal stenosis (HP:0012848)2.73195273
17Duodenal stenosis (HP:0100867)2.73195273
18Patellar aplasia (HP:0006443)2.66315442
19Deviation of the thumb (HP:0009603)2.56243088
20Cortical dysplasia (HP:0002539)2.55993474
21Increased nuchal translucency (HP:0010880)2.50303883
22Breast hypoplasia (HP:0003187)2.49252700
23Absent radius (HP:0003974)2.49100200
24Ependymoma (HP:0002888)2.47147631
25Sloping forehead (HP:0000340)2.44576324
26Aplasia/Hypoplasia of the patella (HP:0006498)2.43455587
27Proximal placement of thumb (HP:0009623)2.40641449
28Abnormality of the fetal cardiovascular system (HP:0010948)2.38988732
29Abnormal umbilical cord blood vessels (HP:0011403)2.38988732
30Single umbilical artery (HP:0001195)2.38988732
31High pitched voice (HP:0001620)2.35553652
32Medulloblastoma (HP:0002885)2.35455480
33Aplasia involving forearm bones (HP:0009822)2.33236228
34Absent forearm bone (HP:0003953)2.33236228
35Colon cancer (HP:0003003)2.32004491
36Triphalangeal thumb (HP:0001199)2.31917166
37Facial cleft (HP:0002006)2.26977790
38Abnormality of the umbilical cord (HP:0010881)2.26525347
39Abnormality of the labia minora (HP:0012880)2.22971503
40Agnosia (HP:0010524)2.22593930
41Clubbing of toes (HP:0100760)2.21304354
42Rhabdomyosarcoma (HP:0002859)2.21026460
43Abnormality of the carotid arteries (HP:0005344)2.19200804
44Absent thumb (HP:0009777)2.17808715
45Prostate neoplasm (HP:0100787)2.17043819
46Prominent nose (HP:0000448)2.16825016
47Abnormality of the duodenum (HP:0002246)2.15645419
48Horseshoe kidney (HP:0000085)2.15015601
49Cafe-au-lait spot (HP:0000957)2.12284412
50Choanal atresia (HP:0000453)2.10860528
51Abnormality of the fingertips (HP:0001211)2.10600673
52Duplicated collecting system (HP:0000081)2.07600848
53Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.07374824
54Short 4th metacarpal (HP:0010044)2.07374824
55Basal cell carcinoma (HP:0002671)2.06831028
56Astrocytoma (HP:0009592)2.05532563
57Abnormality of the astrocytes (HP:0100707)2.05532563
58Squamous cell carcinoma (HP:0002860)2.04370998
59Ankle contracture (HP:0006466)2.03855794
60Facial hemangioma (HP:0000329)2.03704246
61Bone marrow hypocellularity (HP:0005528)2.01207689
62Hypochromic microcytic anemia (HP:0004840)1.99738832
63Spinal cord lesions (HP:0100561)1.99018242
64Syringomyelia (HP:0003396)1.99018242
65Supernumerary spleens (HP:0009799)1.98431029
66Acute myeloid leukemia (HP:0004808)1.98016204
67Poikiloderma (HP:0001029)1.97715211
68Duplication of thumb phalanx (HP:0009942)1.95846539
69Nephroblastoma (Wilms tumor) (HP:0002667)1.95768712
70Short thumb (HP:0009778)1.95470596
71Bifid tongue (HP:0010297)1.95036118
72Abnormality of the calcaneus (HP:0008364)1.94915798
73Hypoplastic pelvis (HP:0008839)1.93819621
74Long eyelashes (HP:0000527)1.93597708
7511 pairs of ribs (HP:0000878)1.90626766
76Neoplasm of the colon (HP:0100273)1.89309431
77Atresia of the external auditory canal (HP:0000413)1.88311133
78Abnormality of the heme biosynthetic pathway (HP:0010472)1.87450365
79Amaurosis fugax (HP:0100576)1.87150970
80Premature rupture of membranes (HP:0001788)1.86103622
81Embryonal renal neoplasm (HP:0011794)1.85278458
82Increased mean platelet volume (HP:0011877)1.84025802
83Tracheoesophageal fistula (HP:0002575)1.83779605
84Deep philtrum (HP:0002002)1.83023941
85Increased density of long bones (HP:0006392)1.82742548
86Abnormal platelet volume (HP:0011876)1.82320588
87Abnormality of reticulocytes (HP:0004312)1.81486146
88Protrusio acetabuli (HP:0003179)1.80915103
89Missing ribs (HP:0000921)1.79834669
90Abnormality of the renal collecting system (HP:0004742)1.79703762
91Poikilocytosis (HP:0004447)1.78153660
92Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76471403
93Premature graying of hair (HP:0002216)1.76194912
94Thrombocytosis (HP:0001894)1.75132718
95Microtia (HP:0008551)1.75044644
96Blepharitis (HP:0000498)1.74965782
97Absent frontal sinuses (HP:0002688)1.74739141
98Abnormality of cells of the erythroid lineage (HP:0012130)1.74551274
99Glioma (HP:0009733)1.74239302
100Aplasia/Hypoplasia of the sternum (HP:0006714)1.73868437
101Abnormal number of incisors (HP:0011064)1.73630601
102Abnormality of chromosome segregation (HP:0002916)1.73619737
103Abnormal number of erythroid precursors (HP:0012131)1.73169341
104Entropion (HP:0000621)1.72719121
105Abnormality of DNA repair (HP:0003254)1.72591635
106Arteriovenous malformation (HP:0100026)1.72341092
107Neoplasm of the oral cavity (HP:0100649)1.71826087
108Abnormal lung lobation (HP:0002101)1.71365499
109Aplastic anemia (HP:0001915)1.71107321
110Aplasia/hypoplasia of the humerus (HP:0006507)1.70784055
111Short middle phalanx of the 5th finger (HP:0004220)1.69485130
112Abnormalities of placenta or umbilical cord (HP:0001194)1.69323474
113Wrist flexion contracture (HP:0001239)1.68607831
114Carpal bone hypoplasia (HP:0001498)1.68267630
115Biliary tract neoplasm (HP:0100574)1.68182754
116Gastrointestinal carcinoma (HP:0002672)1.67505434
117Malignant gastrointestinal tract tumors (HP:0006749)1.67505434
118Overlapping toe (HP:0001845)1.67348285
119Multiple enchondromatosis (HP:0005701)1.67284278
120Ulnar bowing (HP:0003031)1.66424324
121Small hand (HP:0200055)1.66125154
122Ureteral duplication (HP:0000073)1.65142350
123Microglossia (HP:0000171)1.59417021
124Abnormality of the proximal phalanges of the hand (HP:0009834)1.53522158
125Abnormality of methionine metabolism (HP:0010901)1.53354164
126High anterior hairline (HP:0009890)1.52946796
127Aplasia/Hypoplasia of the earlobes (HP:0009906)1.52755944
128Irregular epiphyses (HP:0010582)1.48619532
129Absent epiphyses (HP:0010577)1.47812071
130Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.47812071
131Oligodactyly (hands) (HP:0001180)1.42555508
132Sensory axonal neuropathy (HP:0003390)1.42067243
133Stenosis of the external auditory canal (HP:0000402)1.41593232
134Embryonal neoplasm (HP:0002898)1.41497270
135Bilateral microphthalmos (HP:0007633)1.40779984
136Microvesicular hepatic steatosis (HP:0001414)1.38687000
137Median cleft lip (HP:0000161)1.38112529
138Hypoplasia of the pons (HP:0012110)1.37907698
139Facial asymmetry (HP:0000324)1.37515568
140Astigmatism (HP:0000483)1.36859683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.71976657
2CDK123.77626048
3WEE13.67324125
4NEK23.61963297
5TTK2.71860111
6BRSK22.40954850
7BUB12.32068500
8STK42.20430446
9PLK12.18362938
10AURKB2.14831563
11NEK12.14164210
12STK102.11870012
13VRK22.04525559
14PLK41.95795199
15SRPK11.92841986
16CHEK21.91874197
17EEF2K1.87739483
18ZAK1.87696500
19TLK11.84602371
20CDK41.76529711
21CDK71.75904868
22STK31.73533173
23ATR1.72549395
24MST41.68087058
25EIF2AK11.63463221
26RPS6KB21.59381017
27PLK31.59247505
28MAP3K81.57695671
29TAF11.54309354
30MKNK11.50877475
31CDK61.48444928
32MST1R1.46684566
33VRK11.46671126
34CHEK11.41755957
35PNCK1.41511787
36LATS11.41066333
37TTN1.39571900
38RPS6KA41.38128251
39ERBB41.36171062
40PIM11.31797557
41BRD41.30654228
42BRSK11.26854548
43EPHA21.26448929
44MET1.24899716
45TRPM71.24879548
46TRIM281.23329569
47PKN21.18770709
48MELK1.17846240
49ATM1.12772293
50ACVR1B1.08048015
51PASK1.03657384
52AURKA1.01091429
53MKNK20.99222711
54NME20.97652641
55MAP3K100.93317394
56* CDK20.91870696
57SCYL20.91587172
58NME10.91398163
59CCNB10.90601437
60CDK80.89823429
61PDK20.87570450
62BRAF0.85569885
63STK160.84753481
64PLK20.84715590
65PAK40.82840099
66MAP3K120.82542219
67MAP3K60.82134353
68BMPR1B0.81958781
69SMG10.79202342
70CDK10.77383411
71TNIK0.74525180
72EIF2AK20.72134988
73DYRK30.72065463
74CDK90.69654446
75MYLK0.69013947
76MTOR0.68697916
77RPS6KA50.67677633
78LRRK20.67656369
79TESK20.67352851
80MAP4K10.67309316
81LATS20.66357509
82ALK0.66283268
83PAK20.64946471
84MAP2K30.63229319
85JAK30.61394897
86CLK10.60086942
87TSSK60.59927992
88PTK20.57150133
89NEK90.55361434
90STK390.50426642
91PAK10.50349393
92TGFBR10.50245014
93MARK30.49099867
94BMX0.46502884
95FGFR10.45009742
96DDR20.43723104
97PDGFRA0.42717650
98BCR0.42363300
99EIF2AK30.42068945
100MAPK140.42017483
101FLT30.41691463
102AKT20.41550623
103STK38L0.40908402
104PRKDC0.40238765
105PBK0.38159777
106CHUK0.36898796
107AKT10.36530582
108CSNK2A20.35656261
109CSNK2A10.34740963
110CDK180.32495092
111ERBB30.32369534
112CSNK1D0.31452689
113CSNK1G10.30318256
114PRKCI0.30201977
115MAPK10.30154713
116CSNK1E0.29226257
117CDK150.28817905
118CSF1R0.28722890
119CDK11A0.28438395
120WNK40.26988514
121TRIB30.26383413
122CDK140.25675130
123KIT0.24236070
124MAP3K90.24151732
125ILK0.23909829
126FGR0.23306275
127MATK0.23133973
128GSK3B0.23133055
129IKBKB0.21962939
130NUAK10.21892089
131ICK0.21645974
132IRAK40.21588536
133YES10.20935794

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.35798050
2Mismatch repair_Homo sapiens_hsa034303.78449039
3Cell cycle_Homo sapiens_hsa041103.28330152
4Homologous recombination_Homo sapiens_hsa034402.98416993
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.84743924
6Base excision repair_Homo sapiens_hsa034102.78882584
7Fanconi anemia pathway_Homo sapiens_hsa034602.77696306
8RNA transport_Homo sapiens_hsa030132.77562423
9Spliceosome_Homo sapiens_hsa030402.53317004
10Nucleotide excision repair_Homo sapiens_hsa034202.47820774
11Systemic lupus erythematosus_Homo sapiens_hsa053222.39958889
12One carbon pool by folate_Homo sapiens_hsa006702.39643224
13Non-homologous end-joining_Homo sapiens_hsa034502.07466106
14p53 signaling pathway_Homo sapiens_hsa041152.03173869
15mRNA surveillance pathway_Homo sapiens_hsa030151.88112337
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77743504
17Basal transcription factors_Homo sapiens_hsa030221.77149642
18RNA degradation_Homo sapiens_hsa030181.75553710
19RNA polymerase_Homo sapiens_hsa030201.72030995
20Ribosome_Homo sapiens_hsa030101.70260142
21Viral carcinogenesis_Homo sapiens_hsa052031.59113725
22Protein export_Homo sapiens_hsa030601.55963895
23Pyrimidine metabolism_Homo sapiens_hsa002401.52980708
24MicroRNAs in cancer_Homo sapiens_hsa052061.44146566
25Small cell lung cancer_Homo sapiens_hsa052221.38955463
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.38500062
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33294835
28Selenocompound metabolism_Homo sapiens_hsa004501.23181132
29Folate biosynthesis_Homo sapiens_hsa007901.20403873
30Biosynthesis of amino acids_Homo sapiens_hsa012301.20101798
31Oocyte meiosis_Homo sapiens_hsa041141.19934020
32Herpes simplex infection_Homo sapiens_hsa051681.18835192
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18739354
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17093636
35Pyruvate metabolism_Homo sapiens_hsa006201.16252378
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13164064
37HTLV-I infection_Homo sapiens_hsa051661.09186264
38Epstein-Barr virus infection_Homo sapiens_hsa051691.09005432
39Alcoholism_Homo sapiens_hsa050341.06616296
40Chronic myeloid leukemia_Homo sapiens_hsa052201.06187746
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03926983
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03636304
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98425069
44Proteasome_Homo sapiens_hsa030500.95669623
45Huntingtons disease_Homo sapiens_hsa050160.92816662
46Shigellosis_Homo sapiens_hsa051310.90175444
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88200798
48Antigen processing and presentation_Homo sapiens_hsa046120.84607091
49Hepatitis B_Homo sapiens_hsa051610.83332809
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82204263
51Apoptosis_Homo sapiens_hsa042100.81358405
52N-Glycan biosynthesis_Homo sapiens_hsa005100.81191896
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.81177540
54Adherens junction_Homo sapiens_hsa045200.80848811
55TGF-beta signaling pathway_Homo sapiens_hsa043500.79114698
56Parkinsons disease_Homo sapiens_hsa050120.77903686
57Hematopoietic cell lineage_Homo sapiens_hsa046400.76942389
58Carbon metabolism_Homo sapiens_hsa012000.74773097
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74290031
60Measles_Homo sapiens_hsa051620.74202969
61Steroid biosynthesis_Homo sapiens_hsa001000.73094577
62Fatty acid elongation_Homo sapiens_hsa000620.72990243
63Colorectal cancer_Homo sapiens_hsa052100.71853757
64Pancreatic cancer_Homo sapiens_hsa052120.71825377
65Oxidative phosphorylation_Homo sapiens_hsa001900.71679012
66Bladder cancer_Homo sapiens_hsa052190.70687327
67Hippo signaling pathway_Homo sapiens_hsa043900.70567611
68Purine metabolism_Homo sapiens_hsa002300.70532212
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68157664
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66563842
71Viral myocarditis_Homo sapiens_hsa054160.65994622
72Notch signaling pathway_Homo sapiens_hsa043300.65836694
73Hedgehog signaling pathway_Homo sapiens_hsa043400.65267671
74Proteoglycans in cancer_Homo sapiens_hsa052050.64417402
75ECM-receptor interaction_Homo sapiens_hsa045120.63683374
76Propanoate metabolism_Homo sapiens_hsa006400.63336585
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63281613
78Glutathione metabolism_Homo sapiens_hsa004800.62962130
79Thyroid cancer_Homo sapiens_hsa052160.62786782
80Sulfur relay system_Homo sapiens_hsa041220.60970929
81Prostate cancer_Homo sapiens_hsa052150.59945031
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59693807
83mTOR signaling pathway_Homo sapiens_hsa041500.59372122
84Focal adhesion_Homo sapiens_hsa045100.58738763
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57862312
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.57675362
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57633714
88Pathways in cancer_Homo sapiens_hsa052000.57577308
89Leishmaniasis_Homo sapiens_hsa051400.57267404
90Vitamin B6 metabolism_Homo sapiens_hsa007500.56552598
91Lysine degradation_Homo sapiens_hsa003100.56460083
92Non-small cell lung cancer_Homo sapiens_hsa052230.55891989
93Platelet activation_Homo sapiens_hsa046110.53280796
94Legionellosis_Homo sapiens_hsa051340.53227300
95Influenza A_Homo sapiens_hsa051640.52124425
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.51541097
97Basal cell carcinoma_Homo sapiens_hsa052170.51378410
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51020139
99Primary immunodeficiency_Homo sapiens_hsa053400.50774281
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49911210
101Malaria_Homo sapiens_hsa051440.48573965
102* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47831190
103Melanoma_Homo sapiens_hsa052180.47008967
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46052467
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44897751
106B cell receptor signaling pathway_Homo sapiens_hsa046620.43592649
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43213112
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42530356
109HIF-1 signaling pathway_Homo sapiens_hsa040660.42086837
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41944243
111Toxoplasmosis_Homo sapiens_hsa051450.41843358
112Acute myeloid leukemia_Homo sapiens_hsa052210.41587919
113Tight junction_Homo sapiens_hsa045300.40703042
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40513839
115Alzheimers disease_Homo sapiens_hsa050100.39827746
116TNF signaling pathway_Homo sapiens_hsa046680.39053084
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38911486
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.38467031
119Metabolic pathways_Homo sapiens_hsa011000.38437110
120FoxO signaling pathway_Homo sapiens_hsa040680.37906194
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35921193
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35368873
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34343909
124Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33746419
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32469926
126Endometrial cancer_Homo sapiens_hsa052130.32234966
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.32074248
128Salmonella infection_Homo sapiens_hsa051320.31003225
129Sulfur metabolism_Homo sapiens_hsa009200.30880903
130Wnt signaling pathway_Homo sapiens_hsa043100.29943944
131Pentose phosphate pathway_Homo sapiens_hsa000300.29685581
132Glioma_Homo sapiens_hsa052140.29556300
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29156120
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27582632
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26821816
136Galactose metabolism_Homo sapiens_hsa000520.26326108
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26158862
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24421958
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23498032
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.19757007
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.19520109
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17019711

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