DICER1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.90785254
2nuclear pore organization (GO:0006999)5.32077270
3protein localization to kinetochore (GO:0034501)4.98678664
4* pre-miRNA processing (GO:0031054)4.94370167
5phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.86177261
6mitotic sister chromatid cohesion (GO:0007064)4.44634304
7heterochromatin organization (GO:0070828)4.21731482
8regulation of telomere maintenance via telomerase (GO:0032210)4.19199291
9interkinetic nuclear migration (GO:0022027)4.14384467
10sister chromatid segregation (GO:0000819)4.09740705
11mitotic chromosome condensation (GO:0007076)4.08194469
12pore complex assembly (GO:0046931)4.07329710
13cytoplasmic mRNA processing body assembly (GO:0033962)3.97209644
14regulation of RNA export from nucleus (GO:0046831)3.95378288
15NLS-bearing protein import into nucleus (GO:0006607)3.95047483
16chromatin assembly (GO:0031497)3.92362350
17histone H4-K8 acetylation (GO:0043982)3.92291600
18histone H4-K5 acetylation (GO:0043981)3.92291600
19protein localization to chromosome, centromeric region (GO:0071459)3.90839322
20negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.90011175
21histone H4-K12 acetylation (GO:0043983)3.89162277
22positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.87971445
23mitotic sister chromatid segregation (GO:0000070)3.87243115
24negative regulation of histone methylation (GO:0031061)3.83350430
25histone H4-K16 acetylation (GO:0043984)3.81250260
26detection of molecule of bacterial origin (GO:0032490)3.77692162
27histone H2A monoubiquitination (GO:0035518)3.75139211
28histone H3-K4 methylation (GO:0051568)3.73514441
29regulation of NFAT protein import into nucleus (GO:0051532)3.67994008
30notochord development (GO:0030903)3.55212304
31establishment of protein localization to Golgi (GO:0072600)3.54823390
32retrograde transport, vesicle recycling within Golgi (GO:0000301)3.41852265
33histone H3-K4 trimethylation (GO:0080182)3.41404567
34negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.40643004
35negative regulation of cell cycle G2/M phase transition (GO:1902750)3.40603269
36regulation of sister chromatid cohesion (GO:0007063)3.39900584
37* mRNA stabilization (GO:0048255)3.39394422
38* RNA stabilization (GO:0043489)3.39394422
39regulation of pigment cell differentiation (GO:0050932)3.39179130
40protein targeting to Golgi (GO:0000042)3.38389996
41regulation of nucleobase-containing compound transport (GO:0032239)3.38239650
42cellular response to ethanol (GO:0071361)3.36344161
43mitotic nuclear envelope disassembly (GO:0007077)3.35975038
44nucleus localization (GO:0051647)3.32906673
45positive regulation of gamma-delta T cell activation (GO:0046645)3.30107300
46DNA duplex unwinding (GO:0032508)3.29003552
47regulation of posttranscriptional gene silencing (GO:0060147)3.28508462
48regulation of gene silencing by miRNA (GO:0060964)3.28508462
49regulation of gene silencing by RNA (GO:0060966)3.28508462
50regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.27415826
51glucocorticoid receptor signaling pathway (GO:0042921)3.26688510
52DNA geometric change (GO:0032392)3.24542474
53peptidyl-lysine trimethylation (GO:0018023)3.24107326
54establishment of nucleus localization (GO:0040023)3.21982801
55DNA replication-dependent nucleosome organization (GO:0034723)3.21777277
56DNA replication-dependent nucleosome assembly (GO:0006335)3.21777277
57nuclear envelope disassembly (GO:0051081)3.20840327
58membrane disassembly (GO:0030397)3.20840327
59regulation of nuclear cell cycle DNA replication (GO:0033262)3.19825805
60histone H3-K9 demethylation (GO:0033169)3.19755313
61positive regulation of histone deacetylation (GO:0031065)3.19383687
62paraxial mesoderm development (GO:0048339)3.18464216
63neural tube formation (GO:0001841)3.17286673
64regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.16850838
65regulation of histone H3-K9 methylation (GO:0051570)3.16349917
66stress granule assembly (GO:0034063)3.15721575
67negative regulation of DNA repair (GO:0045738)3.15683425
68nerve growth factor signaling pathway (GO:0038180)3.15229734
69DNA unwinding involved in DNA replication (GO:0006268)3.14409579
70intracellular estrogen receptor signaling pathway (GO:0030520)3.13913097
71embryonic camera-type eye morphogenesis (GO:0048596)3.12691836
72embryonic retina morphogenesis in camera-type eye (GO:0060059)3.10118976
73somite rostral/caudal axis specification (GO:0032525)3.05857117
74cellular extravasation (GO:0045123)3.04239798
75histone lysine methylation (GO:0034968)3.02773446
76regulation of telomere maintenance (GO:0032204)3.02716508
77positive regulation of chromosome segregation (GO:0051984)2.95722171
78protein localization to chromosome (GO:0034502)2.95688763
79peptidyl-lysine dimethylation (GO:0018027)2.93986256
80histone mRNA catabolic process (GO:0071044)2.91615716
81positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.89802234
82positive regulation of mitotic sister chromatid separation (GO:1901970)2.89802234
83positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.89802234
84peptidyl-threonine phosphorylation (GO:0018107)2.89011854
85negative regulation of epidermis development (GO:0045683)2.88865946
86modulation by symbiont of host immune response (GO:0052553)2.88763777
87positive regulation by symbiont of host defense response (GO:0052509)2.88763777
88modulation by symbiont of host defense response (GO:0052031)2.88763777
89modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.88763777
90modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.88763777
91positive regulation by organism of defense response of other organism involved in symbiotic interact2.88763777
92protein localization to microtubule cytoskeleton (GO:0072698)2.88450665
93positive regulation of histone H3-K4 methylation (GO:0051571)2.88394651
94trophectodermal cell differentiation (GO:0001829)2.87266949
95cell fate commitment involved in formation of primary germ layer (GO:0060795)2.86265379
96microglial cell activation (GO:0001774)2.85110791
97regulation of histone H3-K4 methylation (GO:0051569)2.84947017
98positive regulation of gene expression, epigenetic (GO:0045815)2.84923613
99interleukin-6-mediated signaling pathway (GO:0070102)2.84920318
100protein targeting to vacuole (GO:0006623)2.84915340
101protein targeting to lysosome (GO:0006622)2.84915340
102establishment of protein localization to vacuole (GO:0072666)2.84915340
103histone demethylation (GO:0016577)2.83468909
104histone H3-K9 modification (GO:0061647)2.81287807
105gene silencing by RNA (GO:0031047)2.80385656
106dosage compensation (GO:0007549)2.79985926
107primitive streak formation (GO:0090009)2.79823364
108maintenance of protein location in nucleus (GO:0051457)2.79576165
109macrophage activation involved in immune response (GO:0002281)2.79335644
110hippo signaling (GO:0035329)2.79095236
111corticosteroid receptor signaling pathway (GO:0031958)2.77668624
112polarized epithelial cell differentiation (GO:0030859)2.77436591
113histone methylation (GO:0016571)2.76016469
114positive regulation of DNA-templated transcription, initiation (GO:2000144)2.74856166
115body morphogenesis (GO:0010171)2.72747607
116negative regulation of neurotransmitter secretion (GO:0046929)2.72465596
117peptidyl-threonine modification (GO:0018210)2.71613565
118histone H3-K9 methylation (GO:0051567)2.70649143
119chromosome condensation (GO:0030261)2.70366402
120regulation of B cell receptor signaling pathway (GO:0050855)2.69900802
121centrosome localization (GO:0051642)2.69040498
122microtubule anchoring (GO:0034453)2.67946773
123gene silencing (GO:0016458)2.66848830
124neutrophil mediated immunity (GO:0002446)2.65777050
125negative regulation of NF-kappaB import into nucleus (GO:0042347)2.65608390
126folic acid-containing compound biosynthetic process (GO:0009396)2.65321670
127nuclear envelope organization (GO:0006998)2.65244697
128positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.64347800
129positive regulation of DNA-dependent DNA replication (GO:2000105)2.64103724
130DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.63475038
131regulation of mitotic spindle organization (GO:0060236)2.61848090
132regulation of hippo signaling (GO:0035330)2.61740607
133peptidyl-lysine methylation (GO:0018022)2.61439545
134phospholipid translocation (GO:0045332)2.61264057
135lipid translocation (GO:0034204)2.61264057
136regulation of establishment of cell polarity (GO:2000114)2.60841020
137DNA conformation change (GO:0071103)2.60499832
138negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.60399505
139negative regulation of translation, ncRNA-mediated (GO:0040033)2.60399505
140regulation of translation, ncRNA-mediated (GO:0045974)2.60399505
141head development (GO:0060322)2.60294190
142chromatin assembly or disassembly (GO:0006333)2.59016185
143I-kappaB phosphorylation (GO:0007252)2.58181232
144histone H3-K36 demethylation (GO:0070544)2.58016211
145histone lysine demethylation (GO:0070076)2.56933709
146monoubiquitinated protein deubiquitination (GO:0035520)2.56641384
147protein K11-linked deubiquitination (GO:0035871)2.55568217
148dorsal/ventral axis specification (GO:0009950)2.55222816
149regulation of protein polyubiquitination (GO:1902914)2.55199419
150Golgi to endosome transport (GO:0006895)2.55133435
151regulation of spindle organization (GO:0090224)2.55042843
152positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.54449558
153protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.54329843
154insulin-like growth factor receptor signaling pathway (GO:0048009)2.54225096
155detection of external biotic stimulus (GO:0098581)2.52899407
156regulation of gene silencing (GO:0060968)2.52108829
157* regulation of mRNA stability (GO:0043488)2.51389300
158gastrulation with mouth forming second (GO:0001702)2.50795046
159early endosome to late endosome transport (GO:0045022)2.50105402
160macrophage activation (GO:0042116)2.47688251
161positive regulation of macroautophagy (GO:0016239)2.46379216
162regulation of gamma-delta T cell activation (GO:0046643)2.46345754
163hepatocyte apoptotic process (GO:0097284)2.43643837
164genitalia morphogenesis (GO:0035112)2.42775004
165positive regulation of insulin receptor signaling pathway (GO:0046628)2.41745867
166protein localization to cytoskeleton (GO:0044380)2.39807858
167protein dealkylation (GO:0008214)2.39083421
168protein demethylation (GO:0006482)2.39083421
169positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.38384600
170histone-serine phosphorylation (GO:0035404)2.38041130
171negative regulation of fibroblast apoptotic process (GO:2000270)2.36994330
172protein K48-linked deubiquitination (GO:0071108)2.35451016
173negative regulation of B cell proliferation (GO:0030889)2.34672881
174regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.32865284
175detection of other organism (GO:0098543)2.31750065
176myeloid leukocyte mediated immunity (GO:0002444)2.30632246

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.23184334
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.17759006
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.34223524
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.34223524
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.34223524
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.75792216
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.28921913
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.25987872
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.22774468
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.22056737
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.18800412
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.15117975
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.75785532
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.67684949
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.63633262
16MYC_22102868_ChIP-Seq_BL_Human2.61213449
17SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.45925332
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43183356
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.40427819
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.38596199
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31273405
22CDX2_19796622_ChIP-Seq_MESCs_Mouse2.26399302
23ZNF217_24962896_ChIP-Seq_MCF-7_Human2.24481556
24TAF15_26573619_Chip-Seq_HEK293_Human2.21260738
25GBX2_23144817_ChIP-Seq_PC3_Human2.18580129
26ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.17734077
27* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.17195921
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.16958501
29TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.14296256
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.12950968
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08693556
32TCF3_18692474_ChIP-Seq_MESCs_Mouse2.08444243
33SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.05974780
34* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.02075683
35* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.01608158
36GATA1_22025678_ChIP-Seq_K562_Human1.99363599
37FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.96466587
38NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.93613696
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.84610469
40* AHR_22903824_ChIP-Seq_MCF-7_Human1.83097006
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.82290825
42TCF7_22412390_ChIP-Seq_EML_Mouse1.81741792
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.77138644
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.76767506
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.73435782
46TCF3_18692474_ChIP-Seq_MEFs_Mouse1.72766841
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.72432565
48* ARNT_22903824_ChIP-Seq_MCF-7_Human1.72195429
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.70851233
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70717389
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67600705
52DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.67137963
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64670879
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64555400
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.64238387
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62971810
57NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.61029874
58* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59686682
59AR_21909140_ChIP-Seq_LNCAP_Human1.59024994
60BP1_19119308_ChIP-ChIP_Hs578T_Human1.58510103
61* SMAD4_21799915_ChIP-Seq_A2780_Human1.57732961
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.57421179
63TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.56840067
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.55130652
65NANOG_21062744_ChIP-ChIP_HESCs_Human1.52687019
66STAT3_23295773_ChIP-Seq_U87_Human1.52495261
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51726737
68PKCTHETA_26484144_Chip-Seq_BREAST_Human1.51509140
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51416536
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51416536
71POU5F1_16518401_ChIP-PET_MESCs_Mouse1.50434551
72FUS_26573619_Chip-Seq_HEK293_Human1.50066086
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49806558
74TBX3_20139965_ChIP-Seq_ESCs_Mouse1.49289726
75TBX3_20139965_ChIP-Seq_MESCs_Mouse1.49281232
76FOXM1_26456572_ChIP-Seq_MCF-7_Human1.48806776
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47951915
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47873100
79TP53_16413492_ChIP-PET_HCT116_Human1.47615925
80RUNX_20019798_ChIP-Seq_JUKART_Human1.46423597
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.46376518
82ER_23166858_ChIP-Seq_MCF-7_Human1.42353387
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41069481
84CIITA_25753668_ChIP-Seq_RAJI_Human1.40719168
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40684780
86* P300_19829295_ChIP-Seq_ESCs_Human1.39304196
87IRF8_27001747_Chip-Seq_BMDM_Mouse1.38168710
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36647649
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.36244322
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35328844
91* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.34756034
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.34060998
93* TCF4_23295773_ChIP-Seq_U87_Human1.32464816
94FOXO3_23340844_ChIP-Seq_DLD1_Human1.30996341
95FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30834977
96PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29552763
97KDM2B_26808549_Chip-Seq_DND41_Human1.29017095
98FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27557190
99PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.26977381
100AR_21572438_ChIP-Seq_LNCaP_Human1.26920782
101FLI1_27457419_Chip-Seq_LIVER_Mouse1.26446303
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26237673
103* ISL1_27105846_Chip-Seq_CPCs_Mouse1.26073379
104IRF8_21731497_ChIP-ChIP_J774_Mouse1.25694550
105SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25457376
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24802782
107POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.24645205
108E2F1_18555785_Chip-Seq_ESCs_Mouse1.23668653
109SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23219167
110MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21990118
111CHD1_26751641_Chip-Seq_LNCaP_Human1.21695635
112VDR_24787735_ChIP-Seq_THP-1_Human1.21679911
113* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21645226
114IGF1R_20145208_ChIP-Seq_DFB_Human1.21484084
115* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20855541
116TCF4_18268006_ChIP-ChIP_LS174T_Human1.20631576
117* FLI1_21867929_ChIP-Seq_TH2_Mouse1.20493403
118P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20407226
119EWS_26573619_Chip-Seq_HEK293_Human1.20076790
120KDM2B_26808549_Chip-Seq_K562_Human1.19358634
121* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19063634
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18974441
123KDM2B_26808549_Chip-Seq_JURKAT_Human1.18228750
124SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18087180
125CBP_20019798_ChIP-Seq_JUKART_Human1.17620772
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17620772
127TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15479059
128PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15094367
129EZH2_27294783_Chip-Seq_NPCs_Mouse1.14720924
130ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14616628
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13380765
132NCOR1_26117541_ChIP-Seq_K562_Human1.13232598
133KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12862574
134YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12689068
135CMYC_18555785_Chip-Seq_ESCs_Mouse1.12509653
136* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12229718
137PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11328769
138RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10913947
139NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09370773
140NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09370773
141KDM5A_27292631_Chip-Seq_BREAST_Human1.09302738
142CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09109140
143* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08727402
144SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08658640
145MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07518648
146KDM2B_26808549_Chip-Seq_REH_Human1.07500112
147NANOG_18692474_ChIP-Seq_MESCs_Mouse1.06214607
148IRF8_22096565_ChIP-ChIP_GC-B_Human1.05562569
149LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05546012
150RXR_22108803_ChIP-Seq_LS180_Human1.05289331
151P53_22387025_ChIP-Seq_ESCs_Mouse1.05243909
152CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04746953
153NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04691533
154HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04558278
155TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03986353
156SOX2_21211035_ChIP-Seq_LN229_Gbm1.03319981
157GATA6_25053715_ChIP-Seq_YYC3_Human1.00239666
158NANOG_16518401_ChIP-PET_MESCs_Mouse0.98771176
159SOX2_18692474_ChIP-Seq_MESCs_Mouse0.95326687
160KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95281444
161NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94381814
162POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93841595
163* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92937570
164WT1_19549856_ChIP-ChIP_CCG9911_Human0.91431697
165ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90616609
166RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90157352
167KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89685901
168* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.87937418
169FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.86329414
170HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.84721789
171STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84487889
172POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83457288
173* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83371743
174CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83222056
175SOX2_16153702_ChIP-ChIP_HESCs_Human0.82789066
176CREB1_26743006_Chip-Seq_LNCaP_Human0.82387901
177NANOG_18555785_ChIP-Seq_MESCs_Mouse0.81845094
178TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81324894
179YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.81180581
180FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.80746702
181BRD4_25478319_ChIP-Seq_HGPS_Human0.80104907
182FOXA2_19822575_ChIP-Seq_HepG2_Human0.79617196
183TP53_22127205_ChIP-Seq_IMR90_Human0.77232863
184STAT3_1855785_ChIP-Seq_MESCs_Mouse0.76528179
185POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.75703917

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia4.14188283
2MP0004264_abnormal_extraembryonic_tissu3.42987320
3MP0003121_genomic_imprinting3.42432838
4MP0003890_abnormal_embryonic-extraembry3.27175433
5MP0005409_darkened_coat_color3.09255513
6MP0003705_abnormal_hypodermis_morpholog2.86734188
7MP0003123_paternal_imprinting2.83513391
8MP0003122_maternal_imprinting2.71757754
9MP0003787_abnormal_imprinting2.62084155
10MP0010352_gastrointestinal_tract_polyps2.54830726
11MP0005076_abnormal_cell_differentiation2.42578388
12MP0004957_abnormal_blastocyst_morpholog2.34093426
13MP0003724_increased_susceptibility_to2.23665025
14MP0005380_embryogenesis_phenotype2.22518176
15MP0001672_abnormal_embryogenesis/_devel2.22518176
16MP0005174_abnormal_tail_pigmentation2.16559698
17MP0003111_abnormal_nucleus_morphology2.15269332
18MP0006292_abnormal_olfactory_placode2.12106009
19MP0002166_altered_tumor_susceptibility2.11453550
20MP0002084_abnormal_developmental_patter2.10632628
21MP0002088_abnormal_embryonic_growth/wei2.06377969
22MP0003303_peritoneal_inflammation2.05977284
23MP0003984_embryonic_growth_retardation2.05868188
24* MP0003077_abnormal_cell_cycle2.00663713
25MP0010094_abnormal_chromosome_stability2.00318625
26* MP0002085_abnormal_embryonic_tissue1.92241258
27MP0004197_abnormal_fetal_growth/weight/1.91740726
28MP0009703_decreased_birth_body1.84677912
29MP0000537_abnormal_urethra_morphology1.83982866
30* MP0000350_abnormal_cell_proliferation1.83127351
31MP0003690_abnormal_glial_cell1.81748728
32* MP0002086_abnormal_extraembryonic_tissu1.79787581
33MP0000015_abnormal_ear_pigmentation1.79680008
34* MP0001730_embryonic_growth_arrest1.77465173
35MP0003183_abnormal_peptide_metabolism1.75265065
36MP0010030_abnormal_orbit_morphology1.75169434
37MP0001849_ear_inflammation1.73122760
38MP0005499_abnormal_olfactory_system1.71352275
39MP0005394_taste/olfaction_phenotype1.71352275
40MP0001293_anophthalmia1.70952735
41MP0003119_abnormal_digestive_system1.69243309
42MP0002877_abnormal_melanocyte_morpholog1.64060161
43MP0000569_abnormal_digit_pigmentation1.63977564
44* MP0003935_abnormal_craniofacial_develop1.63965035
45* MP0003937_abnormal_limbs/digits/tail_de1.60979951
46MP0004185_abnormal_adipocyte_glucose1.59536168
47MP0003221_abnormal_cardiomyocyte_apopto1.58976972
48* MP0001697_abnormal_embryo_size1.58890948
49MP0009053_abnormal_anal_canal1.58515156
50* MP0010678_abnormal_skin_adnexa1.58437545
51MP0002092_abnormal_eye_morphology1.54869213
52MP0001188_hyperpigmentation1.54218011
53MP0003283_abnormal_digestive_organ1.54094256
54MP0005257_abnormal_intraocular_pressure1.52017224
55MP0003828_pulmonary_edema1.49436928
56MP0004381_abnormal_hair_follicle1.49053755
57MP0003091_abnormal_cell_migration1.48701880
58MP0009672_abnormal_birth_weight1.48504369
59MP0004808_abnormal_hematopoietic_stem1.47612243
60MP0005248_abnormal_Harderian_gland1.47356100
61MP0008961_abnormal_basal_metabolism1.45222724
62MP0000432_abnormal_head_morphology1.42274255
63MP0001835_abnormal_antigen_presentation1.40712732
64MP0008877_abnormal_DNA_methylation1.40669306
65MP0002932_abnormal_joint_morphology1.38912392
66MP0005310_abnormal_salivary_gland1.38525752
67* MP0000428_abnormal_craniofacial_morphol1.38367916
68MP0003755_abnormal_palate_morphology1.36005654
69MP0000733_abnormal_muscle_development1.35236179
70MP0002653_abnormal_ependyma_morphology1.34465566
71MP0005187_abnormal_penis_morphology1.27723767
72MP0003632_abnormal_nervous_system1.26580054
73MP0002233_abnormal_nose_morphology1.26337555
74* MP0002925_abnormal_cardiovascular_devel1.25783545
75MP0010307_abnormal_tumor_latency1.25310941
76* MP0002080_prenatal_lethality1.24932662
77MP0002006_tumorigenesis1.23919047
78MP0003172_abnormal_lysosome_physiology1.23549896
79MP0003693_abnormal_embryo_hatching1.22080910
80MP0002697_abnormal_eye_size1.21940933
81MP0002254_reproductive_system_inflammat1.21885070
82MP0004883_abnormal_blood_vessel1.20640409
83MP0003861_abnormal_nervous_system1.19699637
84MP0003385_abnormal_body_wall1.19452243
85MP0002909_abnormal_adrenal_gland1.19281747
86MP0003195_calcinosis1.18025186
87MP0010234_abnormal_vibrissa_follicle1.15011461
88MP0003938_abnormal_ear_development1.13127687
89MP0001851_eye_inflammation1.12937452
90MP0003868_abnormal_feces_composition1.09348321
91MP0003315_abnormal_perineum_morphology1.08916647
92MP0009115_abnormal_fat_cell1.07360377
93MP0002116_abnormal_craniofacial_bone1.07142656
94MP0000678_abnormal_parathyroid_gland1.03148369
95MP0000516_abnormal_urinary_system1.02038243
96MP0005367_renal/urinary_system_phenotyp1.02038243
97MP0001286_abnormal_eye_development1.01976997
98MP0003943_abnormal_hepatobiliary_system1.00116070
99MP0003300_gastrointestinal_ulcer0.99880242
100* MP0002114_abnormal_axial_skeleton0.99501554
101MP0002396_abnormal_hematopoietic_system0.98579216
102MP0008789_abnormal_olfactory_epithelium0.98475586
103MP0000427_abnormal_hair_cycle0.98270417
104MP0003045_fibrosis0.98197888
105MP0008932_abnormal_embryonic_tissue0.98031085
106* MP0000383_abnormal_hair_follicle0.97239492
107MP0000647_abnormal_sebaceous_gland0.95727244
108MP0002111_abnormal_tail_morphology0.95225476
109MP0003763_abnormal_thymus_physiology0.94195626
110MP0004858_abnormal_nervous_system0.94138587
111MP0003115_abnormal_respiratory_system0.92469153
112MP0000371_diluted_coat_color0.91927637
113MP0003942_abnormal_urinary_system0.91249441
114MP0005451_abnormal_body_composition0.91105878
115MP0000778_abnormal_nervous_system0.90552953
116MP0001915_intracranial_hemorrhage0.90360888
117MP0001800_abnormal_humoral_immune0.90204870
118MP0002938_white_spotting0.89821749
119MP0008770_decreased_survivor_rate0.89286427
120MP0002168_other_aberrant_phenotype0.89167533
121MP0003191_abnormal_cellular_cholesterol0.89163781
122MP0000462_abnormal_digestive_system0.88578652
123MP0000049_abnormal_middle_ear0.88449498
124* MP0000266_abnormal_heart_morphology0.85606977
125MP0003567_abnormal_fetal_cardiomyocyte0.84109126
126MP0002638_abnormal_pupillary_reflex0.83814666
127MP0009780_abnormal_chondrocyte_physiolo0.83742085
128* MP0002081_perinatal_lethality0.83353066
129MP0002249_abnormal_larynx_morphology0.83341979
130MP0004130_abnormal_muscle_cell0.83136767
131MP0002998_abnormal_bone_remodeling0.82665995
132MP0005391_vision/eye_phenotype0.82636245
133MP0000762_abnormal_tongue_morphology0.80694476
134MP0010368_abnormal_lymphatic_system0.80375792
135MP0003252_abnormal_bile_duct0.79659355
136MP0010630_abnormal_cardiac_muscle0.78068958
137MP0000465_gastrointestinal_hemorrhage0.78016649
138MP0001177_atelectasis0.76837838
139MP0003631_nervous_system_phenotype0.75572780
140MP0003566_abnormal_cell_adhesion0.74805769
141MP0002928_abnormal_bile_duct0.73050582
142MP0005666_abnormal_adipose_tissue0.72413556
143* MP0000313_abnormal_cell_death0.71924990
144* MP0008057_abnormal_DNA_replication0.71877896
145MP0005623_abnormal_meninges_morphology0.71872235
146MP0003941_abnormal_skin_development0.71806592
147MP0009250_abnormal_appendicular_skeleto0.71022210
148MP0002419_abnormal_innate_immunity0.68602604
149MP0001186_pigmentation_phenotype0.67542654
150MP0003656_abnormal_erythrocyte_physiolo0.66658333
151MP0004484_altered_response_of0.66617283
152MP0000955_abnormal_spinal_cord0.65518213
153MP0003633_abnormal_nervous_system0.63748286
154MP0004510_myositis0.63306606
155* MP0002398_abnormal_bone_marrow0.63255917
156* MP0000377_abnormal_hair_follicle0.62761621
157MP0002332_abnormal_exercise_endurance0.62131838
158MP0004134_abnormal_chest_morphology0.61833280
159MP0003453_abnormal_keratinocyte_physiol0.60991763
160MP0002452_abnormal_antigen_presenting0.58476311
161* MP0000703_abnormal_thymus_morphology0.57142049

Predicted human phenotypes

RankGene SetZ-score
1* Papillary thyroid carcinoma (HP:0002895)4.45100876
2Hypochromic microcytic anemia (HP:0004840)4.01939268
3Hepatoblastoma (HP:0002884)3.81732636
4Ependymoma (HP:0002888)3.77991979
5Bilateral microphthalmos (HP:0007633)3.75942607
6Volvulus (HP:0002580)3.47911546
7Astrocytoma (HP:0009592)3.18160813
8Abnormality of the astrocytes (HP:0100707)3.18160813
9Acute myeloid leukemia (HP:0004808)2.99381104
10Difficulty running (HP:0009046)2.98833412
11Rib fusion (HP:0000902)2.88626868
12Short 4th metacarpal (HP:0010044)2.87448410
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.87448410
14Macroorchidism (HP:0000053)2.86259651
15Abnormality of the lower motor neuron (HP:0002366)2.85006778
16Eczematoid dermatitis (HP:0000976)2.81064860
17Recurrent bacterial skin infections (HP:0005406)2.77367262
18Renal duplication (HP:0000075)2.73823059
19* Thyroid carcinoma (HP:0002890)2.71097968
20Curly hair (HP:0002212)2.68463889
21Abnormality of the fingertips (HP:0001211)2.67542822
22T lymphocytopenia (HP:0005403)2.65512826
23* Neoplasm of striated muscle (HP:0009728)2.65394371
24Pseudobulbar signs (HP:0002200)2.64266555
25Neoplasm of the oral cavity (HP:0100649)2.64177215
26Increased nuchal translucency (HP:0010880)2.57068852
27Heterotopia (HP:0002282)2.56477392
28Glioma (HP:0009733)2.56112396
29Abnormality of chromosome segregation (HP:0002916)2.54644087
30Low anterior hairline (HP:0000294)2.53871698
31Neonatal hypoglycemia (HP:0001998)2.52333776
32Shawl scrotum (HP:0000049)2.50406466
33Supernumerary ribs (HP:0005815)2.47363920
34Large earlobe (HP:0009748)2.42271212
35Fair hair (HP:0002286)2.33620539
36Abnormal hair whorl (HP:0010721)2.30068903
37Aplasia/Hypoplasia of the sternum (HP:0006714)2.30000658
38Broad thumb (HP:0011304)2.28642916
39Absent frontal sinuses (HP:0002688)2.28453790
40Hip dysplasia (HP:0001385)2.27831256
41Vertebral arch anomaly (HP:0008438)2.27502419
42Aqueductal stenosis (HP:0002410)2.25969073
43Nephroblastoma (Wilms tumor) (HP:0002667)2.25616004
44Skin tags (HP:0010609)2.25348501
45Recurrent abscess formation (HP:0002722)2.24945589
46Abnormality of the 4th metacarpal (HP:0010012)2.23540317
47Cystic hygroma (HP:0000476)2.21056427
48Bifid tongue (HP:0010297)2.20213929
49Abnormality of T cell number (HP:0011839)2.18345779
50Abnormality of the labia minora (HP:0012880)2.15934673
51* Rhabdomyosarcoma (HP:0002859)2.14102179
52Abnormality of the distal phalanx of the thumb (HP:0009617)2.13488957
53Chromsome breakage (HP:0040012)2.12636426
54Long eyelashes (HP:0000527)2.10315197
55Supernumerary bones of the axial skeleton (HP:0009144)2.09640123
56Hypopigmentation of the fundus (HP:0007894)2.08752510
57Impulsivity (HP:0100710)2.08132062
58Neoplasm of the heart (HP:0100544)2.07535848
59Lip pit (HP:0100267)2.07286151
60Thickened calvaria (HP:0002684)2.06770513
61Widely spaced teeth (HP:0000687)2.06428232
62Preauricular skin tag (HP:0000384)2.05989698
63Generalized hypopigmentation of hair (HP:0011358)2.05665194
64Embryonal renal neoplasm (HP:0011794)2.05081230
65Thick eyebrow (HP:0000574)2.04953511
66Gastrointestinal carcinoma (HP:0002672)2.04461351
67Malignant gastrointestinal tract tumors (HP:0006749)2.04461351
68Hypoplastic labia majora (HP:0000059)2.04013669
69Genetic anticipation (HP:0003743)2.03981883
70Gingivitis (HP:0000230)2.03557147
71Conjunctival telangiectasia (HP:0000524)2.03482780
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01443158
73Drooling (HP:0002307)2.01134004
74Protruding tongue (HP:0010808)2.00836284
75Tapered finger (HP:0001182)2.00816700
76Excessive salivation (HP:0003781)1.99556666
77Uterine leiomyosarcoma (HP:0002891)1.99130816
78Leiomyosarcoma (HP:0100243)1.99130816
79Abnormality of incisor morphology (HP:0011063)1.99121310
80Prominent nose (HP:0000448)1.98920125
81Abnormality of the vasculature of the conjunctiva (HP:0008054)1.97811585
82Transitional cell carcinoma of the bladder (HP:0006740)1.93183070
83Short humerus (HP:0005792)1.92282799
84Skin pits (HP:0100276)1.91941232
85Degeneration of the lateral corticospinal tracts (HP:0002314)1.91790738
86Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91790738
87Hyperinsulinemic hypoglycemia (HP:0000825)1.90888899
88Multiple enchondromatosis (HP:0005701)1.90739896
89Spontaneous hematomas (HP:0007420)1.90650330
90Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.90186186
91Deviation of the thumb (HP:0009603)1.89652585
92Truncal obesity (HP:0001956)1.89355944
93Proximal placement of thumb (HP:0009623)1.88886031
94Obsessive-compulsive behavior (HP:0000722)1.88724217
95Inappropriate behavior (HP:0000719)1.88569346
96Midline defect of the nose (HP:0004122)1.87965937
97Facial hemangioma (HP:0000329)1.87621673
98Shallow orbits (HP:0000586)1.87381184
99Broad palm (HP:0001169)1.86573635
100Subacute progressive viral hepatitis (HP:0006572)1.86204734
101Intestinal fistula (HP:0100819)1.86045311
102Atresia of the external auditory canal (HP:0000413)1.86010251
103Sandal gap (HP:0001852)1.85401651
104Trigonocephaly (HP:0000243)1.84668854
105Periodontitis (HP:0000704)1.84642794
106Germ cell neoplasia (HP:0100728)1.83879563
107Abnormality of the nasal septum (HP:0000419)1.83813438
108Abnormality of the salivary glands (HP:0010286)1.83618365
109Cutis marmorata (HP:0000965)1.83444341
110Hyperventilation (HP:0002883)1.83126578
111Anal stenosis (HP:0002025)1.82811899
112Biliary tract neoplasm (HP:0100574)1.82773217
113Abnormality of the ischium (HP:0003174)1.81137858
114Recurrent gram-negative bacterial infections (HP:0005420)1.80865668
115Optic neuritis (HP:0100653)1.80608490
116Retrobulbar optic neuritis (HP:0100654)1.80608490
117Broad phalanges of the hand (HP:0009768)1.80561686
118Abnormality of the labia majora (HP:0012881)1.79039669
119Bladder carcinoma (HP:0002862)1.78630778
120Bladder neoplasm (HP:0009725)1.78630778
121Menstrual irregularities (HP:0000858)1.78578120
122Spinal cord lesions (HP:0100561)1.78066658
123Syringomyelia (HP:0003396)1.78066658
124Long clavicles (HP:0000890)1.77989331
125Disinhibition (HP:0000734)1.75870375
126Subaortic stenosis (HP:0001682)1.75633768
127Abnormality of the left ventricular outflow tract (HP:0011103)1.75633768
128Narrow palate (HP:0000189)1.75570906
129Short 5th finger (HP:0009237)1.75305389
130Cubitus valgus (HP:0002967)1.74809871
131Insidious onset (HP:0003587)1.74015339
132Termporal pattern (HP:0011008)1.74015339
133Cortical dysplasia (HP:0002539)1.73620225
134Urinary bladder sphincter dysfunction (HP:0002839)1.73542186
135Hypoplasia of the maxilla (HP:0000327)1.73511403
136Periauricular skin pits (HP:0100277)1.72523686
137Preauricular pit (HP:0004467)1.72523686
138Skull defect (HP:0001362)1.72175378
139Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.71949835
140Abnormal pancreas size (HP:0012094)1.71139176
141Overgrowth (HP:0001548)1.69945420
142Aplasia/hypoplasia of the humerus (HP:0006507)1.69135766
143Hyperacusis (HP:0010780)1.68878515
144Abnormal lung lobation (HP:0002101)1.68819219
145Broad finger (HP:0001500)1.68692704
146Gingival bleeding (HP:0000225)1.68304763
147Deep philtrum (HP:0002002)1.68024156
148Neoplasm of the adrenal cortex (HP:0100641)1.67232133
149Abnormality of the phalanges of the hallux (HP:0010057)1.66889720
150Abnormality of the corticospinal tract (HP:0002492)1.66027112
151Ulnar bowing (HP:0003031)1.65415176
152Abnormality of the pubic bones (HP:0003172)1.65232948
153Viral hepatitis (HP:0006562)1.65032048
154Lymphangioma (HP:0100764)1.64976451
155Urethral obstruction (HP:0000796)1.64796722
156Scanning speech (HP:0002168)1.64525834
157Abnormality of the diencephalon (HP:0010662)1.64425268
158Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.63271134
159Ectopic kidney (HP:0000086)1.62094094
160Coarse hair (HP:0002208)1.61303673
161Vertebral fusion (HP:0002948)1.61173862
162Hemivertebrae (HP:0002937)1.61151525
163Asymmetry of the thorax (HP:0001555)1.61085231
164Cafe-au-lait spot (HP:0000957)1.60934628
165Resting tremor (HP:0002322)1.60823082
166Abnormality of the axillary hair (HP:0100134)1.60756593
167Abnormality of secondary sexual hair (HP:0009888)1.60756593
168Abnormal number of incisors (HP:0011064)1.60658422
169Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.59947489
170Blue irides (HP:0000635)1.59716717
171Thyroiditis (HP:0100646)1.59639183
172Thickened helices (HP:0000391)1.59550233
173Smooth philtrum (HP:0000319)1.59421460
174Mask-like facies (HP:0000298)1.58278100
175Renovascular hypertension (HP:0100817)1.57648806
176Prominent occiput (HP:0000269)1.57513847
177Abnormality of the musculature of the hand (HP:0001421)1.57204753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.61270264
2LATS13.68183676
3MAP3K93.14479140
4SGK22.76302083
5CDC72.69429093
6MAP3K102.56342636
7FRK2.53267941
8TTK2.50419625
9EEF2K2.10518412
10RIPK12.07236065
11TYRO32.07205232
12STK102.02013292
13TNIK1.98604163
14CASK1.82327996
15NLK1.80312439
16BRD41.74763661
17YES11.74458018
18MARK11.67791714
19NEK21.67715833
20SGK2231.63988178
21SGK4941.63988178
22LATS21.62579344
23PDGFRA1.61276057
24ERN11.59178836
25CAMK1G1.58674316
26CAMK1D1.55686998
27STK31.55684605
28MTOR1.54297018
29WNK11.52580296
30TAF11.51319343
31GRK61.51158753
32MAP3K21.46199587
33MAP3K141.45806878
34ALK1.44558210
35BLK1.43259313
36ACVR1B1.42899944
37PKN21.37439979
38FGR1.35498795
39CHEK11.30194538
40KSR11.28309087
41CHEK21.27200380
42TRIB31.25029327
43PIK3CG1.22236149
44RIPK41.22183901
45CDK71.19954596
46ICK1.18293808
47IRAK11.16348907
48GRK51.15527403
49IRAK21.13246330
50HIPK21.11381310
51FGFR31.10851716
52CDK41.06063333
53CSF1R1.03991836
54ATM1.03842481
55MAP3K131.01158062
56TAOK31.00730289
57MAP3K40.98770484
58RPS6KB20.96978344
59PDGFRB0.96971837
60MKNK20.96440420
61PRKD30.95533765
62BMPR1B0.94400684
63MARK20.94189681
64NEK90.94054712
65JAK10.92918605
66CDK60.92910137
67KSR20.92790796
68MELK0.92338488
69STK38L0.92017204
70CDK20.90832572
71ERBB30.89309620
72MAPK70.88875981
73PLK10.87579354
74SGK10.87310165
75PIK3CA0.83477627
76ATR0.82815439
77RPS6KB10.82139197
78FGFR20.81137338
79TGFBR20.79859681
80MAP3K70.79021336
81PASK0.78238215
82ERBB20.77648035
83PTK60.77245997
84CDK90.76910544
85PNCK0.76424885
86STK240.75974034
87CSNK1D0.75285106
88DMPK0.74184404
89CSNK1E0.74162140
90MKNK10.73845930
91JAK20.72484562
92TEC0.71428866
93STK110.71140136
94CDK10.71133278
95NTRK30.70577787
96CDK30.70020937
97NUAK10.69615674
98SIK10.69125811
99TRPM70.68939246
100TYK20.67836524
101BTK0.67723776
102PAK40.67003025
103CAMKK20.65922041
104CSNK1A1L0.65663118
105MAP3K80.65623385
106HCK0.65039192
107PTK20.64169269
108EPHA30.64062192
109IRAK40.63520720
110MAPK140.63229530
111MAP2K40.63152948
112MAP3K60.62810396
113IKBKE0.62646515
114FGFR40.62356628
115MAP2K30.61067101
116MAPK100.59966591
117MAPK130.58718533
118GSK3B0.58346681
119BMX0.56692806
120GRK10.56150478
121PAK30.55970354
122EPHA20.55908279
123STK380.55505433
124WNK30.55260114
125TTN0.54824081
126CHUK0.54720016
127NTRK10.54218351
128NEK60.53610100
129PRKAA10.53407434
130RET0.53274547
131MET0.53092503
132INSRR0.52251902
133AKT30.51736171
134AURKB0.51666106
135DYRK1A0.51420340
136PRKD20.50626577
137CDC42BPA0.50484790
138STK40.50205620
139MAPK10.50176223
140FGFR10.50069558
141PRKDC0.49448479
142EGFR0.49280424
143FES0.48627056
144CAMK40.48502478
145AKT20.48079008
146PAK20.47880899
147AKT10.46913861
148JAK30.46693821
149SYK0.46412082
150CSNK1G10.45108158
151PRKAA20.45076792
152PTK2B0.44829784
153ERBB40.44198365
154SIK20.43429570
155TAOK10.43328213
156NTRK20.42948190
157STK390.42852231
158FER0.41337603
159PDK10.38764028
160SGK30.38327738
161CSK0.37419204

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.68059345
2mRNA surveillance pathway_Homo sapiens_hsa030152.27042178
3mTOR signaling pathway_Homo sapiens_hsa041502.08059700
4Cell cycle_Homo sapiens_hsa041102.00995912
5Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.94552830
6RNA transport_Homo sapiens_hsa030131.91276307
7Basal cell carcinoma_Homo sapiens_hsa052171.82690213
8* MicroRNAs in cancer_Homo sapiens_hsa052061.80782274
9Adherens junction_Homo sapiens_hsa045201.74373593
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69762555
11Hippo signaling pathway_Homo sapiens_hsa043901.57888493
12Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.57632324
13One carbon pool by folate_Homo sapiens_hsa006701.54424593
14Dorso-ventral axis formation_Homo sapiens_hsa043201.54302184
15Thyroid hormone signaling pathway_Homo sapiens_hsa049191.53518415
16Osteoclast differentiation_Homo sapiens_hsa043801.48342940
17Thyroid cancer_Homo sapiens_hsa052161.39183702
18Hedgehog signaling pathway_Homo sapiens_hsa043401.38826346
19Endometrial cancer_Homo sapiens_hsa052131.34951872
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.34104262
21Chronic myeloid leukemia_Homo sapiens_hsa052201.33859543
22Vitamin B6 metabolism_Homo sapiens_hsa007501.31740016
23Colorectal cancer_Homo sapiens_hsa052101.29814588
24Non-small cell lung cancer_Homo sapiens_hsa052231.29288372
25Long-term potentiation_Homo sapiens_hsa047201.28553571
26Notch signaling pathway_Homo sapiens_hsa043301.26129174
27Proteoglycans in cancer_Homo sapiens_hsa052051.23769213
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23727336
29Non-homologous end-joining_Homo sapiens_hsa034501.21734579
30RNA degradation_Homo sapiens_hsa030181.21105824
31Leishmaniasis_Homo sapiens_hsa051401.20267656
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.19356881
33Wnt signaling pathway_Homo sapiens_hsa043101.18156936
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15164920
35Type II diabetes mellitus_Homo sapiens_hsa049301.15104489
36TGF-beta signaling pathway_Homo sapiens_hsa043501.13693749
37Prostate cancer_Homo sapiens_hsa052151.13559552
38AMPK signaling pathway_Homo sapiens_hsa041521.11214404
39Pancreatic cancer_Homo sapiens_hsa052121.11022429
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10760649
41Platelet activation_Homo sapiens_hsa046111.10409796
42Measles_Homo sapiens_hsa051621.08154015
43Insulin resistance_Homo sapiens_hsa049311.06123430
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.05250857
45Small cell lung cancer_Homo sapiens_hsa052221.04540557
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.04489526
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03927904
48Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03872675
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03776188
50Tuberculosis_Homo sapiens_hsa051521.02915318
51NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02689969
52Selenocompound metabolism_Homo sapiens_hsa004501.02396993
53Fanconi anemia pathway_Homo sapiens_hsa034601.01676866
54Oocyte meiosis_Homo sapiens_hsa041141.00649080
55Choline metabolism in cancer_Homo sapiens_hsa052310.99311504
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97784258
57Nitrogen metabolism_Homo sapiens_hsa009100.97361107
58Renal cell carcinoma_Homo sapiens_hsa052110.97346800
59Tight junction_Homo sapiens_hsa045300.96660232
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.96588748
61Pathways in cancer_Homo sapiens_hsa052000.96334581
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94368738
63Spliceosome_Homo sapiens_hsa030400.93588976
64Chemokine signaling pathway_Homo sapiens_hsa040620.93518867
65HTLV-I infection_Homo sapiens_hsa051660.93508276
66Hepatitis C_Homo sapiens_hsa051600.93438956
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.93030036
68Toxoplasmosis_Homo sapiens_hsa051450.89875198
69Ovarian steroidogenesis_Homo sapiens_hsa049130.88336531
70Circadian rhythm_Homo sapiens_hsa047100.88177045
71Glioma_Homo sapiens_hsa052140.87627968
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87610552
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.86011916
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84884945
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84394125
76Viral carcinogenesis_Homo sapiens_hsa052030.83678927
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83418735
78Focal adhesion_Homo sapiens_hsa045100.81436837
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81351513
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.81147521
81Inositol phosphate metabolism_Homo sapiens_hsa005620.80974841
82FoxO signaling pathway_Homo sapiens_hsa040680.80897352
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80885980
84Influenza A_Homo sapiens_hsa051640.80758454
85Staphylococcus aureus infection_Homo sapiens_hsa051500.79619509
86p53 signaling pathway_Homo sapiens_hsa041150.78510479
87Renin secretion_Homo sapiens_hsa049240.78477927
88Amoebiasis_Homo sapiens_hsa051460.77825591
89TNF signaling pathway_Homo sapiens_hsa046680.77672067
90Bladder cancer_Homo sapiens_hsa052190.77210257
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76778132
92ErbB signaling pathway_Homo sapiens_hsa040120.74946830
93Acute myeloid leukemia_Homo sapiens_hsa052210.73767128
94Prolactin signaling pathway_Homo sapiens_hsa049170.73651499
95Cholinergic synapse_Homo sapiens_hsa047250.73441887
96Rap1 signaling pathway_Homo sapiens_hsa040150.72966262
97Estrogen signaling pathway_Homo sapiens_hsa049150.71962967
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71382828
99Fatty acid biosynthesis_Homo sapiens_hsa000610.71024927
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70399569
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69875899
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68075079
103GnRH signaling pathway_Homo sapiens_hsa049120.68018166
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66644386
105Mismatch repair_Homo sapiens_hsa034300.66556297
106Gap junction_Homo sapiens_hsa045400.65684239
107HIF-1 signaling pathway_Homo sapiens_hsa040660.65428464
108Insulin signaling pathway_Homo sapiens_hsa049100.64881328
109Viral myocarditis_Homo sapiens_hsa054160.63994853
110Legionellosis_Homo sapiens_hsa051340.62770066
111Axon guidance_Homo sapiens_hsa043600.62623143
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62213238
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62014500
114VEGF signaling pathway_Homo sapiens_hsa043700.61908240
115MAPK signaling pathway_Homo sapiens_hsa040100.61347880
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60482081
117Herpes simplex infection_Homo sapiens_hsa051680.58038897
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56846669
119Oxytocin signaling pathway_Homo sapiens_hsa049210.55481033
120T cell receptor signaling pathway_Homo sapiens_hsa046600.54825967
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54816849
122Melanogenesis_Homo sapiens_hsa049160.54166111
123Glucagon signaling pathway_Homo sapiens_hsa049220.53696777
124Melanoma_Homo sapiens_hsa052180.53080863
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51451271
126B cell receptor signaling pathway_Homo sapiens_hsa046620.49098612
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48118992
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.44970834
129Homologous recombination_Homo sapiens_hsa034400.44249991
130ECM-receptor interaction_Homo sapiens_hsa045120.42590829
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41826978
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.41589278
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40447503
134Ras signaling pathway_Homo sapiens_hsa040140.40263511
135Basal transcription factors_Homo sapiens_hsa030220.40021372
136Long-term depression_Homo sapiens_hsa047300.39034026
137Hepatitis B_Homo sapiens_hsa051610.38975901

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