DIDO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.64371913
2histone H3-K36 demethylation (GO:0070544)4.39602560
3mitotic sister chromatid cohesion (GO:0007064)3.99240385
4mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.89935242
5nuclear pore organization (GO:0006999)3.89404707
6regulation of nucleobase-containing compound transport (GO:0032239)3.88787193
7regulation of histone H3-K9 methylation (GO:0051570)3.84793996
8mitotic chromosome condensation (GO:0007076)3.84117589
9spliceosomal tri-snRNP complex assembly (GO:0000244)3.83290396
10peptidyl-threonine dephosphorylation (GO:0035970)3.78493337
11regulation of NFAT protein import into nucleus (GO:0051532)3.76205243
12positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.69172657
13DNA ligation (GO:0006266)3.63382839
14embryonic process involved in female pregnancy (GO:0060136)3.61998887
15regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.55960030
16genitalia morphogenesis (GO:0035112)3.55902952
17regulation of DNA endoreduplication (GO:0032875)3.46101401
18regulation of stem cell maintenance (GO:2000036)3.44949907
19definitive hemopoiesis (GO:0060216)3.44309463
20pore complex assembly (GO:0046931)3.44015751
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.41289016
22adherens junction assembly (GO:0034333)3.38703814
23histone H3-K4 methylation (GO:0051568)3.36211393
24focal adhesion assembly (GO:0048041)3.35508659
25cell-substrate adherens junction assembly (GO:0007045)3.35508659
26histone lysine demethylation (GO:0070076)3.35059244
27DNA replication initiation (GO:0006270)3.30294280
28glucocorticoid receptor signaling pathway (GO:0042921)3.29154794
29histone H3-K4 trimethylation (GO:0080182)3.28837195
30regulation of chromatin binding (GO:0035561)3.27686759
31negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.25707810
32regulation of mammary gland epithelial cell proliferation (GO:0033599)3.25362043
33negative regulation of histone methylation (GO:0031061)3.25146225
34interkinetic nuclear migration (GO:0022027)3.20839592
35histone demethylation (GO:0016577)3.18997287
36endothelium development (GO:0003158)3.17906556
37pattern specification involved in kidney development (GO:0061004)3.16585541
38negative regulation of DNA-dependent DNA replication (GO:2000104)3.16002347
39histone H3-K9 demethylation (GO:0033169)3.15963431
40cellular response to epidermal growth factor stimulus (GO:0071364)3.15846737
41telomere maintenance via semi-conservative replication (GO:0032201)3.15106785
42nephron tubule formation (GO:0072079)3.13585888
43regulation of histone H3-K4 methylation (GO:0051569)3.09312806
44response to folic acid (GO:0051593)3.08282855
45negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.07346529
46chromatin assembly (GO:0031497)3.06836591
47negative regulation of RNA splicing (GO:0033119)3.06250064
48kinetochore organization (GO:0051383)3.02609112
49regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.02431337
50DNA unwinding involved in DNA replication (GO:0006268)3.02186976
51corticosteroid receptor signaling pathway (GO:0031958)3.00596369
52DNA duplex unwinding (GO:0032508)2.98775573
53activation of Rac GTPase activity (GO:0032863)2.96982165
54urogenital system development (GO:0001655)2.96222381
55negative regulation of granulocyte differentiation (GO:0030853)2.95904460
56DNA geometric change (GO:0032392)2.95425072
57stress granule assembly (GO:0034063)2.95083417
58pre-miRNA processing (GO:0031054)2.94656365
593-UTR-mediated mRNA stabilization (GO:0070935)2.93998334
60negative regulation of erythrocyte differentiation (GO:0045647)2.93427190
61viral transcription (GO:0019083)2.92795065
62response to epidermal growth factor (GO:0070849)2.91845015
63regulation of apoptotic process involved in morphogenesis (GO:1902337)2.91422727
64mitotic recombination (GO:0006312)2.90608150
65telomere maintenance via recombination (GO:0000722)2.90486360
66Golgi transport vesicle coating (GO:0048200)2.89381357
67COPI coating of Golgi vesicle (GO:0048205)2.89381357
68dosage compensation (GO:0007549)2.89283939
69positive regulation of hormone metabolic process (GO:0032352)2.88572145
70peptidyl-lysine dimethylation (GO:0018027)2.87752031
71sister chromatid cohesion (GO:0007062)2.87751311
72negative regulation of mRNA processing (GO:0050686)2.86974600
73regulation of cholesterol homeostasis (GO:2000188)2.83469854
74maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80922030
75translational termination (GO:0006415)2.79895798
76heterochromatin organization (GO:0070828)2.77579262
77intracellular estrogen receptor signaling pathway (GO:0030520)2.77490638
78megakaryocyte development (GO:0035855)2.76662284
79DNA dealkylation (GO:0035510)2.76550688
80protein dealkylation (GO:0008214)2.76480223
81protein demethylation (GO:0006482)2.76480223
82trophectodermal cell differentiation (GO:0001829)2.76271400
83lymphoid progenitor cell differentiation (GO:0002320)2.75011599
84peptidyl-lysine trimethylation (GO:0018023)2.74725593
85regulation of histone methylation (GO:0031060)2.74710260
86histone H4-K12 acetylation (GO:0043983)2.74148791
87protein localization to kinetochore (GO:0034501)2.74100375
88apoptotic process involved in morphogenesis (GO:0060561)2.73650446
89regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.72321610
90histone H4-K16 acetylation (GO:0043984)2.71888068
91embryonic camera-type eye morphogenesis (GO:0048596)2.71788174
92cell-substrate junction assembly (GO:0007044)2.70667659
93positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.68550423
94determination of adult lifespan (GO:0008340)2.67080643
95protein export from nucleus (GO:0006611)2.66863120
96DNA strand elongation involved in DNA replication (GO:0006271)2.66627602
97negative regulation of myotube differentiation (GO:0010832)2.65916403
98regulation of nuclear cell cycle DNA replication (GO:0033262)2.65161289
99mannose metabolic process (GO:0006013)2.64322348
100regulation of histone H3-K27 methylation (GO:0061085)2.63642581
101nucleosome disassembly (GO:0006337)2.62850916
102protein-DNA complex disassembly (GO:0032986)2.62850916
103positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.62455207
104positive regulation of gamma-delta T cell activation (GO:0046645)2.61897361
105chromosome condensation (GO:0030261)2.61376765
106DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.60739549
107embryonic eye morphogenesis (GO:0048048)2.60657196
108mRNA splice site selection (GO:0006376)2.60139808
109cytoplasmic mRNA processing body assembly (GO:0033962)2.59362459
110insulin-like growth factor receptor signaling pathway (GO:0048009)2.59172164
111response to laminar fluid shear stress (GO:0034616)2.59049194
112histone lysine methylation (GO:0034968)2.59048461
113kinetochore assembly (GO:0051382)2.58954095
114embryonic hemopoiesis (GO:0035162)2.58272896
115negative regulation of mRNA metabolic process (GO:1903312)2.57345203
116positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.56866724
117epithelial cell differentiation involved in prostate gland development (GO:0060742)2.56022577
118negative regulation of cell size (GO:0045792)2.55723547
119regulation of mitotic spindle organization (GO:0060236)2.55697779
120regulation of glucose import in response to insulin stimulus (GO:2001273)2.55584282
121intra-S DNA damage checkpoint (GO:0031573)2.55573531
122histone mRNA catabolic process (GO:0071044)2.55504047
123negative regulation of metanephros development (GO:0072217)2.54200327
124RNA stabilization (GO:0043489)2.53686101
125mRNA stabilization (GO:0048255)2.53686101
126regulation of RNA export from nucleus (GO:0046831)2.52640782
127protein localization to chromosome, centromeric region (GO:0071459)2.52414289
128histone H3 acetylation (GO:0043966)2.52129202
129DNA strand elongation (GO:0022616)2.52115321
130mesenchymal to epithelial transition (GO:0060231)2.51391012
131negative regulation of viral release from host cell (GO:1902187)2.50450740
132DNA conformation change (GO:0071103)2.48983891
133positive regulation of gene expression, epigenetic (GO:0045815)2.48647646
134positive regulation of histone deacetylation (GO:0031065)2.48630515
135maternal placenta development (GO:0001893)2.47462173
136cytoskeletal anchoring at plasma membrane (GO:0007016)2.47152652
137regulation of DNA damage checkpoint (GO:2000001)2.47055150
138positive regulation of cell cycle checkpoint (GO:1901978)2.47041529
139histone H3-K9 methylation (GO:0051567)2.46906970
140histone H4-K5 acetylation (GO:0043981)2.46831923
141histone H4-K8 acetylation (GO:0043982)2.46831923
142negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.46720539
143negative regulation of translation, ncRNA-mediated (GO:0040033)2.46720539
144regulation of translation, ncRNA-mediated (GO:0045974)2.46720539
145peptidyl-threonine phosphorylation (GO:0018107)2.46531274
146mitotic nuclear envelope disassembly (GO:0007077)2.45927767
147histone methylation (GO:0016571)2.45753989
148positive regulation of cell cycle G2/M phase transition (GO:1902751)2.45543502
149positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.45543502
150sister chromatid segregation (GO:0000819)2.45485131
151negative regulation of fatty acid transport (GO:2000192)2.44828497
152nuclear envelope disassembly (GO:0051081)2.43741546
153membrane disassembly (GO:0030397)2.43741546
154nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.43702100
155negative regulation of chromatin modification (GO:1903309)2.43516156
156peptidyl-threonine modification (GO:0018210)2.43277573
157histone deubiquitination (GO:0016578)2.43247381
158regulation of gene silencing (GO:0060968)2.43234259
159negative regulation of DNA repair (GO:0045738)2.42605918
160facial nerve structural organization (GO:0021612)2.42187179
161negative regulation of histone modification (GO:0031057)2.41640885
162DNA topological change (GO:0006265)2.41286461
163nephron epithelium development (GO:0072009)2.40300319
164telomere maintenance via telomere lengthening (GO:0010833)2.40080814
165mesonephros development (GO:0001823)2.39982435
166regulation of mRNA stability (GO:0043488)2.39489331
167retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.38632680
168histone H4 deacetylation (GO:0070933)2.38592291
169regulation of translational fidelity (GO:0006450)2.34631312
170mitotic sister chromatid segregation (GO:0000070)2.34339228
171NLS-bearing protein import into nucleus (GO:0006607)2.32103801
172nuclear envelope organization (GO:0006998)2.31750815

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.38859099
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.99733640
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.46995690
4* MYC_22102868_ChIP-Seq_BL_Human3.16591558
5SCL_19346495_ChIP-Seq_HPC-7_Human3.11603588
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.08739987
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.78229721
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.67975772
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.56348308
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.55551526
11VDR_21846776_ChIP-Seq_THP-1_Human2.55317878
12* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.39994106
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.33494798
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.27265177
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.17120950
16* TCF7_22412390_ChIP-Seq_EML_Mouse2.08460462
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.08336227
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.06331764
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05955369
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04577578
21E2F7_22180533_ChIP-Seq_HELA_Human10.6060390
22CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.99036482
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.98719286
24* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.98456634
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.95331566
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.95331566
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.95331566
28MYB_26560356_Chip-Seq_TH1_Human1.94259584
29ZNF263_19887448_ChIP-Seq_K562_Human1.93244032
30RACK7_27058665_Chip-Seq_MCF-7_Human1.87696000
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86494777
32MYC_18555785_ChIP-Seq_MESCs_Mouse1.85041630
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.82953983
34VDR_24763502_ChIP-Seq_THP-1_Human1.82840356
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.76122245
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.76106002
37MAF_26560356_Chip-Seq_TH1_Human1.74846836
38LXR_22292898_ChIP-Seq_THP-1_Human1.72373280
39* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.70217603
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69021291
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68931660
42CIITA_25753668_ChIP-Seq_RAJI_Human1.66895324
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.65033317
44CLOCK_20551151_ChIP-Seq_293T_Human1.64916935
45UTX_26944678_Chip-Seq_JUKART_Human1.64128639
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60734324
47KDM2B_26808549_Chip-Seq_K562_Human1.59183963
48MYB_26560356_Chip-Seq_TH2_Human1.57839884
49* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57415623
50* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.56949101
51* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52762847
52* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.52488641
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51218906
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50383924
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.49564830
56AR_21909140_ChIP-Seq_LNCAP_Human1.48488462
57RUNX1_27514584_Chip-Seq_MCF-7_Human1.48338600
58* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48220679
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47757811
60HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47594385
61* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47014246
62* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46879413
63* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46694821
64* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43873626
65* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43792111
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43670386
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43025125
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42417856
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40182728
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.40050615
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38926564
72P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35462265
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35031460
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34531203
75RUNX_20019798_ChIP-Seq_JUKART_Human1.34043330
76CHD1_26751641_Chip-Seq_LNCaP_Human1.33415773
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33124693
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32452691
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.31613832
80EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31247779
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31049538
82* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28865776
83IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27762610
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27113838
85* KDM2B_26808549_Chip-Seq_JURKAT_Human1.26506384
86SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25076760
87SPI1_23547873_ChIP-Seq_NB4_Human1.24821970
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24134948
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23949924
90* KDM2B_26808549_Chip-Seq_DND41_Human1.23040668
91* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22990092
92ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22669744
93* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21107225
94CREB1_26743006_Chip-Seq_LNCaP_Human1.18533862
95* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.18031765
96* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16785591
97PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16736475
98* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15038971
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.14316483
100SPI1_23127762_ChIP-Seq_K562_Human1.14199746
101* SMC4_20622854_ChIP-Seq_HELA_Human1.13500963
102STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13336781
103NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13211891
104ATF3_27146783_Chip-Seq_COLON_Human1.12757478
105* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12519687
106PU_27001747_Chip-Seq_BMDM_Mouse1.12215305
107ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11957722
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10857552
109ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10584737
110EZH2_22144423_ChIP-Seq_EOC_Human1.09962408
111KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09923769
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09525895
113SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08354443
114* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07958585
115SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07162025
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06991751
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06774021
118* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06258297
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05339095
120UBF1/2_26484160_Chip-Seq_HMECs_Human1.04057543
121POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03658566
122NCOR1_26117541_ChIP-Seq_K562_Human1.02652274
123SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01748478
124GATA6_25053715_ChIP-Seq_YYC3_Human1.01642389
125* KDM5A_27292631_Chip-Seq_BREAST_Human1.01335509
126STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01196184
127TP53_22127205_ChIP-Seq_IMR90_Human1.01073209
128MAF_26560356_Chip-Seq_TH2_Human1.00349623
129ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99772596
130HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99389522
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98539905
132FOXA2_19822575_ChIP-Seq_HepG2_Human0.98471569
133* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98332091
134* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97804598
135GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97717006
136NANOG_21062744_ChIP-ChIP_HESCs_Human0.97694783
137FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.96729544
138GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94177945
139E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93657625
140CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92425500
141MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.92216800
142* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91212092
143DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86928032
144MYCN_18555785_ChIP-Seq_MESCs_Mouse0.86176877
145* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84848713
146GATA1_22025678_ChIP-Seq_K562_Human0.82968296
147RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.80201812
148FOXP3_21729870_ChIP-Seq_TREG_Human0.79546004
149* IRF8_27001747_Chip-Seq_BMDM_Mouse0.78562204
150PCGF2_27294783_Chip-Seq_NPCs_Mouse0.77185768
151NANOG_18555785_ChIP-Seq_MESCs_Mouse0.75853101
152VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.74763238
153PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.74677167
154* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.73499643
155FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.73349688
156* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.72871819
157* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.71890308
158* GATA1_19941827_ChIP-Seq_MEL_Mouse0.71414707

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.96807783
2MP0003705_abnormal_hypodermis_morpholog3.65465045
3MP0005174_abnormal_tail_pigmentation3.44728497
4MP0005409_darkened_coat_color3.12033844
5MP0008057_abnormal_DNA_replication3.09767190
6MP0003303_peritoneal_inflammation3.03854068
7MP0003136_yellow_coat_color2.86319258
8MP0002396_abnormal_hematopoietic_system2.77955139
9MP0005451_abnormal_body_composition2.60902132
10MP0010094_abnormal_chromosome_stability2.53494668
11MP0004264_abnormal_extraembryonic_tissu2.41472327
12MP0000015_abnormal_ear_pigmentation2.39361792
13MP0004185_abnormal_adipocyte_glucose2.35267933
14MP0003724_increased_susceptibility_to2.21101074
15MP0006292_abnormal_olfactory_placode2.19785666
16MP0001188_hyperpigmentation2.17358893
17MP0003566_abnormal_cell_adhesion2.12435055
18MP0010234_abnormal_vibrissa_follicle2.09604427
19MP0004808_abnormal_hematopoietic_stem2.07724926
20MP0002166_altered_tumor_susceptibility2.02829166
21MP0002095_abnormal_skin_pigmentation2.00150046
22MP0003763_abnormal_thymus_physiology1.98265928
23MP0001730_embryonic_growth_arrest1.94564796
24MP0003111_abnormal_nucleus_morphology1.93880951
25MP0004381_abnormal_hair_follicle1.93633601
26MP0000490_abnormal_crypts_of1.92378352
27MP0000569_abnormal_digit_pigmentation1.87738145
28MP0005397_hematopoietic_system_phenotyp1.87065726
29MP0001545_abnormal_hematopoietic_system1.87065726
30MP0005075_abnormal_melanosome_morpholog1.85613836
31MP0004233_abnormal_muscle_weight1.83332423
32MP0008007_abnormal_cellular_replicative1.80720773
33MP0003828_pulmonary_edema1.79102255
34MP0008058_abnormal_DNA_repair1.67579604
35MP0001849_ear_inflammation1.67162582
36MP0003091_abnormal_cell_migration1.67137103
37MP0003077_abnormal_cell_cycle1.64975597
38MP0000537_abnormal_urethra_morphology1.58699884
39MP0005076_abnormal_cell_differentiation1.55795137
40MP0009672_abnormal_birth_weight1.54489130
41MP0001915_intracranial_hemorrhage1.52663566
42MP0008260_abnormal_autophagy1.51421494
43MP0009278_abnormal_bone_marrow1.51111047
44MP0002249_abnormal_larynx_morphology1.50537583
45MP0010307_abnormal_tumor_latency1.47000076
46MP0002075_abnormal_coat/hair_pigmentati1.46279683
47MP0002006_tumorigenesis1.46113852
48MP0002796_impaired_skin_barrier1.46000670
49MP0002177_abnormal_outer_ear1.45398938
50MP0002089_abnormal_postnatal_growth/wei1.40048378
51MP0003123_paternal_imprinting1.38641876
52MP0003453_abnormal_keratinocyte_physiol1.38166610
53MP0003868_abnormal_feces_composition1.37839899
54MP0010352_gastrointestinal_tract_polyps1.37021550
55* MP0002398_abnormal_bone_marrow1.35718713
56MP0000003_abnormal_adipose_tissue1.32846841
57MP0003693_abnormal_embryo_hatching1.32094734
58MP0005621_abnormal_cell_physiology1.31461724
59MP0003786_premature_aging1.31104500
60MP0000371_diluted_coat_color1.30874598
61MP0004957_abnormal_blastocyst_morpholog1.30012295
62MP0003115_abnormal_respiratory_system1.28610536
63MP0000049_abnormal_middle_ear1.28074089
64MP0000703_abnormal_thymus_morphology1.27694860
65MP0001835_abnormal_antigen_presentation1.27592265
66MP0001348_abnormal_lacrimal_gland1.27504394
67MP0001800_abnormal_humoral_immune1.26009426
68MP0005666_abnormal_adipose_tissue1.24630758
69MP0001697_abnormal_embryo_size1.21545542
70MP0000733_abnormal_muscle_development1.19449771
71MP0009333_abnormal_splenocyte_physiolog1.17645582
72MP0001986_abnormal_taste_sensitivity1.17090251
73MP0010630_abnormal_cardiac_muscle1.16857390
74MP0005671_abnormal_response_to1.16041874
75* MP0000689_abnormal_spleen_morphology1.15883900
76MP0005375_adipose_tissue_phenotype1.14593733
77MP0002009_preneoplasia1.14512059
78MP0000350_abnormal_cell_proliferation1.13893519
79MP0000685_abnormal_immune_system1.13718681
80MP0005501_abnormal_skin_physiology1.12454226
81MP0000465_gastrointestinal_hemorrhage1.12413392
82MP0004858_abnormal_nervous_system1.11311800
83MP0002933_joint_inflammation1.08306245
84* MP0002722_abnormal_immune_system1.07593860
85MP0002060_abnormal_skin_morphology1.02378964
86MP0003172_abnormal_lysosome_physiology1.01727209
87MP0009703_decreased_birth_body0.99634624
88MP0002019_abnormal_tumor_incidence0.99397085
89MP0004197_abnormal_fetal_growth/weight/0.99158845
90MP0004947_skin_inflammation0.99080172
91MP0005384_cellular_phenotype0.97281448
92MP0001661_extended_life_span0.96998935
93MP0000428_abnormal_craniofacial_morphol0.96992794
94* MP0000716_abnormal_immune_system0.94741579
95MP0001293_anophthalmia0.94617520
96MP0002102_abnormal_ear_morphology0.94589552
97MP0001873_stomach_inflammation0.93664253
98MP0008961_abnormal_basal_metabolism0.92550703
99MP0002420_abnormal_adaptive_immunity0.92195430
100MP0003300_gastrointestinal_ulcer0.92137758
101MP0000313_abnormal_cell_death0.91769255
102MP0005623_abnormal_meninges_morphology0.91558814
103MP0002085_abnormal_embryonic_tissue0.91032916
104MP0002925_abnormal_cardiovascular_devel0.90978080
105MP0005257_abnormal_intraocular_pressure0.90083791
106MP0001186_pigmentation_phenotype0.89786452
107MP0000432_abnormal_head_morphology0.89677466
108MP0002452_abnormal_antigen_presenting0.89354968
109MP0001819_abnormal_immune_cell0.89247625
110MP0005380_embryogenesis_phenotype0.88862641
111MP0001672_abnormal_embryogenesis/_devel0.88862641
112MP0002210_abnormal_sex_determination0.88637500
113MP0000858_altered_metastatic_potential0.88170496
114MP0000372_irregular_coat_pigmentation0.87867491
115MP0002084_abnormal_developmental_patter0.87471336
116MP0010155_abnormal_intestine_physiology0.86819729
117MP0003935_abnormal_craniofacial_develop0.85955144
118* MP0002429_abnormal_blood_cell0.85356466
119MP0000681_abnormal_thyroid_gland0.85086555
120MP0002098_abnormal_vibrissa_morphology0.84866267
121MP0002723_abnormal_immune_serum0.83800871
122MP0001346_abnormal_lacrimal_gland0.83733669
123MP0003436_decreased_susceptibility_to0.83588077
124MP0002086_abnormal_extraembryonic_tissu0.83391744
125MP0000377_abnormal_hair_follicle0.83183788
126MP0003984_embryonic_growth_retardation0.83148428
127MP0002088_abnormal_embryonic_growth/wei0.82955080
128MP0001216_abnormal_epidermal_layer0.81215036
129MP0003191_abnormal_cellular_cholesterol0.80342367
130MP0008877_abnormal_DNA_methylation0.78071629
131MP0003221_abnormal_cardiomyocyte_apopto0.77990717
132MP0000477_abnormal_intestine_morphology0.77734132
133MP0002877_abnormal_melanocyte_morpholog0.76900846
134MP0003941_abnormal_skin_development0.76593736
135MP0000678_abnormal_parathyroid_gland0.76572603
136MP0009931_abnormal_skin_appearance0.75351116
137MP0003567_abnormal_fetal_cardiomyocyte0.73868610
138MP0003938_abnormal_ear_development0.73213790
139MP0004087_abnormal_muscle_fiber0.73030952
140MP0002092_abnormal_eye_morphology0.72332663
141MP0009115_abnormal_fat_cell0.72002202
142MP0008995_early_reproductive_senescence0.71949242
143MP0002970_abnormal_white_adipose0.71822546
144MP0008932_abnormal_embryonic_tissue0.71748276
145MP0000566_synostosis0.71598424
146MP0003942_abnormal_urinary_system0.71126700
147MP0005058_abnormal_lysosome_morphology0.70829032
148MP0003890_abnormal_embryonic-extraembry0.70714656
149MP0010030_abnormal_orbit_morphology0.69939431
150MP0003943_abnormal_hepatobiliary_system0.69403100
151MP0005025_abnormal_response_to0.69153206
152MP0005000_abnormal_immune_tolerance0.68220279
153MP0002080_prenatal_lethality0.67436794
154MP0003646_muscle_fatigue0.67176351

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)4.45899785
2Abnormality of the fingertips (HP:0001211)3.77114168
3Type I transferrin isoform profile (HP:0003642)3.59941447
4Hyperacusis (HP:0010780)3.33352442
5Thyroid-stimulating hormone excess (HP:0002925)3.28459870
6Broad face (HP:0000283)3.19646596
7Chromsome breakage (HP:0040012)3.00661423
8Flat acetabular roof (HP:0003180)3.00410658
9Volvulus (HP:0002580)2.90938854
10Chromosomal breakage induced by crosslinking agents (HP:0003221)2.90454369
11Asymmetry of the thorax (HP:0001555)2.86337468
12Acute lymphatic leukemia (HP:0006721)2.84024186
13Ankle contracture (HP:0006466)2.73777162
14Absent rod-and cone-mediated responses on ERG (HP:0007688)2.73552090
15Acute myeloid leukemia (HP:0004808)2.72951820
16Dislocated radial head (HP:0003083)2.68002152
17Abnormality of the distal phalanx of the thumb (HP:0009617)2.65594695
18Sparse lateral eyebrow (HP:0005338)2.62297998
19Long eyelashes (HP:0000527)2.57591328
20Dysmetric saccades (HP:0000641)2.53457704
21Abnormality of the radial head (HP:0003995)2.42921815
22Clubbing of toes (HP:0100760)2.41523440
23Urethral obstruction (HP:0000796)2.40541441
24Narrow palate (HP:0000189)2.40535281
25Obstructive sleep apnea (HP:0002870)2.37541587
26Deep venous thrombosis (HP:0002625)2.35371925
27Medulloblastoma (HP:0002885)2.34970454
28Ulnar bowing (HP:0003031)2.34414903
29Vertebral arch anomaly (HP:0008438)2.33852191
30Smooth philtrum (HP:0000319)2.30039909
31Attenuation of retinal blood vessels (HP:0007843)2.29452163
32Abnormality of chromosome stability (HP:0003220)2.28420636
33Ankyloglossia (HP:0010296)2.27096815
34Broad palm (HP:0001169)2.26702514
35Subacute progressive viral hepatitis (HP:0006572)2.26475161
36Ectopic kidney (HP:0000086)2.25827169
37Severe visual impairment (HP:0001141)2.21675264
38Abnormal protein glycosylation (HP:0012346)2.18692154
39Abnormal glycosylation (HP:0012345)2.18692154
40Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.18692154
41Abnormal protein N-linked glycosylation (HP:0012347)2.18692154
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.18608094
43Depressed nasal tip (HP:0000437)2.16736184
44Lip pit (HP:0100267)2.16686132
45Deep philtrum (HP:0002002)2.15532966
46Macroorchidism (HP:0000053)2.14588991
47Prominent nose (HP:0000448)2.14174872
48Rhabdomyosarcoma (HP:0002859)2.11631988
49Intestinal fistula (HP:0100819)2.10818244
50Pendular nystagmus (HP:0012043)2.10669684
51Prolonged bleeding time (HP:0003010)2.10263503
52Myelodysplasia (HP:0002863)2.08682171
53Disproportionate tall stature (HP:0001519)2.07721985
54Absent frontal sinuses (HP:0002688)2.07319720
55Hypothermia (HP:0002045)2.07149099
56Persistence of primary teeth (HP:0006335)2.06238506
57Advanced eruption of teeth (HP:0006288)2.06080454
58Meckel diverticulum (HP:0002245)2.05667128
59Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.05475949
60Deviation of the thumb (HP:0009603)2.05456044
61Abnormality of oral frenula (HP:0000190)2.04756862
62Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.04681028
63Short 4th metacarpal (HP:0010044)2.04681028
64Supernumerary ribs (HP:0005815)2.04405468
65Abnormality of the ileum (HP:0001549)2.04186775
66Neonatal hypoglycemia (HP:0001998)2.03505217
67Abnormality of the columella (HP:0009929)2.03385663
68Anal stenosis (HP:0002025)2.02698219
69Neoplasm of the oral cavity (HP:0100649)2.02527477
70Septate vagina (HP:0001153)2.01720130
71Reticulocytopenia (HP:0001896)2.01017878
72Long palpebral fissure (HP:0000637)2.00776098
73Agammaglobulinemia (HP:0004432)1.99284113
74Flat occiput (HP:0005469)1.99115965
75Abnormal foot bone ossification (HP:0010675)1.98488478
76Small hand (HP:0200055)1.97598688
77Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.97555003
78Supernumerary spleens (HP:0009799)1.97097391
79Trigonocephaly (HP:0000243)1.92185057
80Abnormality of the preputium (HP:0100587)1.91691742
81Truncal obesity (HP:0001956)1.91382154
82Abnormal ossification of hand bones (HP:0005921)1.91118166
83Germ cell neoplasia (HP:0100728)1.90244061
84Amaurosis fugax (HP:0100576)1.89980160
85Heterotopia (HP:0002282)1.89972094
86Nephroblastoma (Wilms tumor) (HP:0002667)1.89871682
87Abnormality of the humeroradial joint (HP:0100744)1.89547215
88Neoplasm of striated muscle (HP:0009728)1.89321360
89Cellulitis (HP:0100658)1.89145554
90Overlapping toe (HP:0001845)1.89016567
91Panhypogammaglobulinemia (HP:0003139)1.88957227
92Supernumerary bones of the axial skeleton (HP:0009144)1.87799496
93Spinal cord lesions (HP:0100561)1.87682047
94Syringomyelia (HP:0003396)1.87682047
95Sandal gap (HP:0001852)1.85597399
96Abnormality of the carotid arteries (HP:0005344)1.85467001
97Obsessive-compulsive behavior (HP:0000722)1.83189583
98Laryngomalacia (HP:0001601)1.82688141
99Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.82038112
100Recurrent viral infections (HP:0004429)1.81746129
101Colitis (HP:0002583)1.81316219
102Absent thumb (HP:0009777)1.80990860
103Microcytic anemia (HP:0001935)1.80717340
104Progressive external ophthalmoplegia (HP:0000590)1.79421167
105Bronchomalacia (HP:0002780)1.79385420
106Thoracic kyphosis (HP:0002942)1.79153293
107Abnormality of carpal bone ossification (HP:0006257)1.78802614
108Increased connective tissue (HP:0009025)1.78730249
109Increased nuchal translucency (HP:0010880)1.78384032
110Embryonal renal neoplasm (HP:0011794)1.78161893
111Malignant gastrointestinal tract tumors (HP:0006749)1.77813122
112Gastrointestinal carcinoma (HP:0002672)1.77813122
113Abnormality of the phalanges of the hallux (HP:0010057)1.76283555
114Distal lower limb amyotrophy (HP:0008944)1.76008243
115Hemorrhage of the eye (HP:0011885)1.75228665
116Abnormal rod and cone electroretinograms (HP:0008323)1.75058207
117Pointed chin (HP:0000307)1.74399490
118Deep palmar crease (HP:0006191)1.74309140
119Limited elbow extension (HP:0001377)1.73525535
120Viral hepatitis (HP:0006562)1.73197714
121Skin tags (HP:0010609)1.72874659
122Basal cell carcinoma (HP:0002671)1.72404337
123Selective tooth agenesis (HP:0001592)1.71635678
124Midline defect of the nose (HP:0004122)1.71288930
125Abnormality of the nasal septum (HP:0000419)1.71178698
126Mitral valve prolapse (HP:0001634)1.70678797
127Leiomyosarcoma (HP:0100243)1.70490935
128Uterine leiomyosarcoma (HP:0002891)1.70490935
129Hypochromic anemia (HP:0001931)1.70180135
130Cerebral aneurysm (HP:0004944)1.69900132
131Recurrent fungal infections (HP:0002841)1.69497979
132Arnold-Chiari malformation (HP:0002308)1.69470783
133Shallow orbits (HP:0000586)1.69363601
134Meningitis (HP:0001287)1.69049992
135Self-mutilation (HP:0000742)1.68648444
136Abnormal number of incisors (HP:0011064)1.68647039
137Stomatitis (HP:0010280)1.67918340
138Mitral regurgitation (HP:0001653)1.67855012
139Chronic mucocutaneous candidiasis (HP:0002728)1.67747170
140Recurrent cutaneous fungal infections (HP:0011370)1.67747170
141Rib fusion (HP:0000902)1.67195615
142Micronodular cirrhosis (HP:0001413)1.67138032
143Thrombocytosis (HP:0001894)1.67132733
144Entropion (HP:0000621)1.66686383
145Precocious puberty (HP:0000826)1.66588017
14611 pairs of ribs (HP:0000878)1.66493669
147Large earlobe (HP:0009748)1.64587131
148Sparse scalp hair (HP:0002209)1.64019997
149Proximal placement of thumb (HP:0009623)1.63901679
150Renovascular hypertension (HP:0100817)1.63742348
151Abnormality of the peritoneum (HP:0002585)1.62412910
152Aplasia/Hypoplasia of the sacrum (HP:0008517)1.62297186
153Short nail (HP:0001799)1.62274008
154Anal atresia (HP:0002023)1.62250148
155Hepatoblastoma (HP:0002884)1.61448394
156Ocular albinism (HP:0001107)1.61205053
157Cutis marmorata (HP:0000965)1.61169972
158Protrusio acetabuli (HP:0003179)1.61089089
159Abnormal number of erythroid precursors (HP:0012131)1.60616649
160Centrally nucleated skeletal muscle fibers (HP:0003687)1.60478551
161Bowel incontinence (HP:0002607)1.60463458
162Insomnia (HP:0100785)1.60434365
163Thin bony cortex (HP:0002753)1.59714890
164Hypoplasia of the radius (HP:0002984)1.58713600
165Abnormality of the thoracic spine (HP:0100711)1.58418823
166Knee flexion contracture (HP:0006380)1.57959114
167Patellar dislocation (HP:0002999)1.55927272
168Metaphyseal cupping (HP:0003021)1.55544284
169Abnormality of the calcaneus (HP:0008364)1.55082875
170High anterior hairline (HP:0009890)1.54126942
171Renal cell carcinoma (HP:0005584)1.54011582
172Aneurysm (HP:0002617)1.53577614
173Abnormal tarsal ossification (HP:0008369)1.53462822
174Biconcave vertebral bodies (HP:0004586)1.52348136
175Termporal pattern (HP:0011008)1.51026275
176Insidious onset (HP:0003587)1.51026275
177Distal upper limb amyotrophy (HP:0007149)1.50663733
178Upper limb amyotrophy (HP:0009129)1.50663733
179Transitional cell carcinoma of the bladder (HP:0006740)1.49764410

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.94516188
2TRIB34.53086378
3MKNK23.89893066
4CDK123.72073273
5SMG13.55762453
6NLK3.23639299
7FES2.95046669
8FGFR42.84707386
9TLK12.66129117
10EIF2AK32.49741192
11MKNK12.47740309
12BRD41.90664483
13EEF2K1.89528276
14MUSK1.81130980
15SRPK11.76539726
16ERN11.73705938
17FLT31.63064772
18CDC71.61588779
19NEK21.59251073
20CDK71.51636643
21CSK1.46008016
22TEC1.45978347
23CLK11.45944831
24PDGFRA1.44211935
25KIT1.43920921
26CDK91.43583049
27CAMK1D1.42964270
28YES11.42600226
29RIPK11.40122343
30SCYL21.38443224
31WEE11.38026127
32TTN1.35831310
33EIF2AK21.34334664
34CDK41.32533385
35MAP4K11.29703609
36MAP3K101.26186950
37PRKD21.22510605
38PRPF4B1.20857198
39CDK61.18887106
40EPHA21.16954123
41PIM11.13026091
42CSF1R1.11222143
43DYRK31.08329855
44HIPK21.07072807
45PRKAA21.03280268
46ATR1.02032537
47MAP3K130.99526854
48ACVR1B0.98881098
49STK40.98089744
50MAP3K70.97761900
51CAMK10.96529332
52MELK0.95739740
53KSR20.95731527
54BTK0.93882862
55ZAK0.88422458
56CDC42BPA0.88133897
57RET0.87487587
58FER0.87124260
59HCK0.86275360
60RPS6KB20.86049352
61FGFR30.85802754
62MAP2K30.85054030
63ATM0.84895943
64CAMK1G0.84864065
65TYRO30.84644867
66DYRK1B0.83715800
67TGFBR20.83168322
68PTK60.81857822
69SGK30.80329783
70TXK0.79401682
71LATS10.77843687
72LCK0.76981571
73CHEK20.76379736
74AKT30.74288142
75FGFR20.73109124
76MTOR0.71321763
77MAPK110.69894481
78WNK10.69293770
79CAMK40.68566573
80LATS20.67881128
81LYN0.67551980
82MST1R0.66487219
83MATK0.64867221
84ICK0.64339249
85RIPK40.64154971
86MAP3K20.63431082
87MAP3K80.61309027
88SIK20.61234913
89AURKB0.60884035
90PDGFRB0.60702946
91EPHB10.60650866
92IRAK40.60309440
93MAP3K10.59525580
94CHEK10.59521420
95TAOK10.59133459
96STK100.57795644
97RPS6KC10.56522521
98RPS6KL10.56522521
99PKN20.56368990
100MAPK40.55816665
101TRPM70.55649662
102DMPK0.54198997
103PDPK10.54045631
104MAP3K140.53946533
105IKBKB0.51843544
106PRKDC0.51220699
107CDK20.51186351
108RPS6KA20.50732935
109SIK10.50629517
110MAPK100.50234054
111FGFR10.49364073
112PASK0.49060868
113CAMKK20.48591745
114PAK40.48244961
115PTK20.48026745
116PLK10.47961414
117IRAK30.47286195
118CASK0.46932474
119NEK60.46690830
120JAK30.45748100
121MAP3K30.45440865
122MAPK140.45126705
123RPS6KA60.44765043
124IRAK20.43749960
125CHUK0.42870864
126BMX0.41898056
127TGFBR10.41459617
128TYK20.40769802
129NUAK10.40624069
130JAK10.40595721
131SIK30.40484231
132NEK90.40224831
133CSNK1D0.40031037
134PAK20.39948159
135MARK20.39936304
136PDK10.39010994
137ZAP700.38650297
138CSNK1G10.38361851
139AKT10.37867980
140TTK0.37849763
141RPS6KB10.37090842
142MAP3K60.36753670
143PRKAA10.36624592
144MAPK10.35713050
145PRKD30.35684667
146RPS6KA50.35571955
147ALK0.35461927
148RPS6KA10.34935130
149TNK20.34282262
150* GSK3B0.34056785
151* CDK10.33795766
152MAPK70.32993390
153GRK60.31953239
154ABL10.31785648

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.24037873
2Fanconi anemia pathway_Homo sapiens_hsa034602.41649591
3One carbon pool by folate_Homo sapiens_hsa006702.37118110
4Homologous recombination_Homo sapiens_hsa034402.32553166
5Mismatch repair_Homo sapiens_hsa034302.26304946
6Systemic lupus erythematosus_Homo sapiens_hsa053222.25346388
7Transcriptional misregulation in cancer_Homo sapiens_hsa052022.21989134
8Base excision repair_Homo sapiens_hsa034102.19328313
9Primary immunodeficiency_Homo sapiens_hsa053402.12285215
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.09001943
11Non-homologous end-joining_Homo sapiens_hsa034502.00785476
12Spliceosome_Homo sapiens_hsa030401.92456963
13Thyroid cancer_Homo sapiens_hsa052161.90841205
14Lysine degradation_Homo sapiens_hsa003101.87230204
15Ribosome_Homo sapiens_hsa030101.67109228
16Herpes simplex infection_Homo sapiens_hsa051681.62020815
17Cell cycle_Homo sapiens_hsa041101.54370587
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.52488514
19mRNA surveillance pathway_Homo sapiens_hsa030151.46622718
20Acute myeloid leukemia_Homo sapiens_hsa052211.46255836
21Renal cell carcinoma_Homo sapiens_hsa052111.45604762
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43565210
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.39745846
24ErbB signaling pathway_Homo sapiens_hsa040121.34560051
25Glioma_Homo sapiens_hsa052141.34532395
26Nucleotide excision repair_Homo sapiens_hsa034201.33236645
27Hematopoietic cell lineage_Homo sapiens_hsa046401.32398769
28Bladder cancer_Homo sapiens_hsa052191.29804402
29VEGF signaling pathway_Homo sapiens_hsa043701.28978439
30Basal cell carcinoma_Homo sapiens_hsa052171.28205013
31p53 signaling pathway_Homo sapiens_hsa041151.27999126
32B cell receptor signaling pathway_Homo sapiens_hsa046621.27189608
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.26037586
34MicroRNAs in cancer_Homo sapiens_hsa052061.25885047
35Phototransduction_Homo sapiens_hsa047441.25607364
36Insulin signaling pathway_Homo sapiens_hsa049101.22853412
37Measles_Homo sapiens_hsa051621.22579760
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.20934111
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.18935881
40Choline metabolism in cancer_Homo sapiens_hsa052311.18463352
41RNA transport_Homo sapiens_hsa030131.17184029
42Notch signaling pathway_Homo sapiens_hsa043301.16936660
43Small cell lung cancer_Homo sapiens_hsa052221.12047776
44Viral carcinogenesis_Homo sapiens_hsa052031.10872969
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09261136
46Prolactin signaling pathway_Homo sapiens_hsa049171.06527524
47Insulin resistance_Homo sapiens_hsa049311.03943803
48Wnt signaling pathway_Homo sapiens_hsa043101.02959460
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02832631
50Alcoholism_Homo sapiens_hsa050341.02155719
51Basal transcription factors_Homo sapiens_hsa030221.00588515
52HTLV-I infection_Homo sapiens_hsa051660.99806896
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98379371
54Chronic myeloid leukemia_Homo sapiens_hsa052200.97917057
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97469266
56Hepatitis C_Homo sapiens_hsa051600.96713468
57Hepatitis B_Homo sapiens_hsa051610.95691357
58Sulfur relay system_Homo sapiens_hsa041220.93184930
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.92937643
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91853404
61Prostate cancer_Homo sapiens_hsa052150.91172572
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90125996
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88505528
64Estrogen signaling pathway_Homo sapiens_hsa049150.87320364
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.86432839
66RNA degradation_Homo sapiens_hsa030180.86317532
67N-Glycan biosynthesis_Homo sapiens_hsa005100.83225178
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.81781968
69HIF-1 signaling pathway_Homo sapiens_hsa040660.81345113
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79444895
71Adherens junction_Homo sapiens_hsa045200.79211101
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77782748
73Pathways in cancer_Homo sapiens_hsa052000.77492240
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76821473
75GnRH signaling pathway_Homo sapiens_hsa049120.76711308
76Colorectal cancer_Homo sapiens_hsa052100.76695947
77Malaria_Homo sapiens_hsa051440.76390355
78Osteoclast differentiation_Homo sapiens_hsa043800.73507724
79Glucagon signaling pathway_Homo sapiens_hsa049220.72274086
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71864907
81Leishmaniasis_Homo sapiens_hsa051400.71430361
82Type II diabetes mellitus_Homo sapiens_hsa049300.71003207
83Platelet activation_Homo sapiens_hsa046110.70205405
84Fructose and mannose metabolism_Homo sapiens_hsa000510.69172811
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69025858
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.67847305
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67722702
88T cell receptor signaling pathway_Homo sapiens_hsa046600.67329043
89Biosynthesis of amino acids_Homo sapiens_hsa012300.65761258
90ABC transporters_Homo sapiens_hsa020100.65446331
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65269017
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64216393
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63307948
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.62351814
95Antigen processing and presentation_Homo sapiens_hsa046120.62268742
96Long-term potentiation_Homo sapiens_hsa047200.61673658
97Pentose phosphate pathway_Homo sapiens_hsa000300.61477951
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61332726
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61165564
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59818120
101Influenza A_Homo sapiens_hsa051640.59652458
102Viral myocarditis_Homo sapiens_hsa054160.58335829
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58132934
104TGF-beta signaling pathway_Homo sapiens_hsa043500.57807224
105Inositol phosphate metabolism_Homo sapiens_hsa005620.54756225
106Hippo signaling pathway_Homo sapiens_hsa043900.54687548
107AMPK signaling pathway_Homo sapiens_hsa041520.54568791
108Endometrial cancer_Homo sapiens_hsa052130.54330891
109Endocytosis_Homo sapiens_hsa041440.53499568
110Non-small cell lung cancer_Homo sapiens_hsa052230.53221184
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52871641
112Amoebiasis_Homo sapiens_hsa051460.52248929
113TNF signaling pathway_Homo sapiens_hsa046680.52193510
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52019850
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.52016145
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51120004
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50815795
118Proteoglycans in cancer_Homo sapiens_hsa052050.50447450
119Tight junction_Homo sapiens_hsa045300.49544391
120Pyrimidine metabolism_Homo sapiens_hsa002400.49042184
121Fatty acid biosynthesis_Homo sapiens_hsa000610.48492023
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48184488
123Prion diseases_Homo sapiens_hsa050200.48155518
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47669839
125Other glycan degradation_Homo sapiens_hsa005110.43103943
126Caffeine metabolism_Homo sapiens_hsa002320.42452264
127Melanoma_Homo sapiens_hsa052180.42019440
128Apoptosis_Homo sapiens_hsa042100.41806361
129Epstein-Barr virus infection_Homo sapiens_hsa051690.40649742
130mTOR signaling pathway_Homo sapiens_hsa041500.40486133
131Pancreatic cancer_Homo sapiens_hsa052120.40406746
132Focal adhesion_Homo sapiens_hsa045100.40263943
133ECM-receptor interaction_Homo sapiens_hsa045120.39939095
134Toxoplasmosis_Homo sapiens_hsa051450.38741710
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38598291
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38569728
137Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38139267
138FoxO signaling pathway_Homo sapiens_hsa040680.37184525

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