DIEXF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heterochromatin organization (GO:0070828)4.88611256
2protein localization to kinetochore (GO:0034501)4.72550196
3nuclear pore organization (GO:0006999)4.68887131
4nuclear pore complex assembly (GO:0051292)4.58573483
5DNA unwinding involved in DNA replication (GO:0006268)4.51844159
6mitotic nuclear envelope disassembly (GO:0007077)4.10172333
7mitotic sister chromatid cohesion (GO:0007064)4.06679086
8folic acid-containing compound biosynthetic process (GO:0009396)4.05497462
9tRNA methylation (GO:0030488)4.01832256
10pre-miRNA processing (GO:0031054)3.98889700
11maturation of 5.8S rRNA (GO:0000460)3.97825785
12regulation of RNA export from nucleus (GO:0046831)3.94028639
13DNA duplex unwinding (GO:0032508)3.93038799
14ribosomal large subunit biogenesis (GO:0042273)3.91974750
15pseudouridine synthesis (GO:0001522)3.89280276
16DNA geometric change (GO:0032392)3.89165881
17DNA replication initiation (GO:0006270)3.85098786
18DNA replication checkpoint (GO:0000076)3.84959703
19nuclear envelope disassembly (GO:0051081)3.81563978
20membrane disassembly (GO:0030397)3.81563978
21protein localization to chromosome, centromeric region (GO:0071459)3.76511704
22IMP biosynthetic process (GO:0006188)3.72110499
23maturation of SSU-rRNA (GO:0030490)3.69768797
24negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.68480291
25regulation of histone H3-K9 methylation (GO:0051570)3.68301354
26regulation of centriole replication (GO:0046599)3.66376636
27alternative mRNA splicing, via spliceosome (GO:0000380)3.65543705
28negative regulation of histone methylation (GO:0031061)3.61372949
29mitochondrial RNA metabolic process (GO:0000959)3.59703820
30protein K11-linked deubiquitination (GO:0035871)3.56385013
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.49801416
32mitotic metaphase plate congression (GO:0007080)3.48339712
33nucleobase biosynthetic process (GO:0046112)3.46825627
34ribosome assembly (GO:0042255)3.45603479
35non-recombinational repair (GO:0000726)3.44360978
36double-strand break repair via nonhomologous end joining (GO:0006303)3.44360978
37mitotic sister chromatid segregation (GO:0000070)3.41935346
38DNA replication-dependent nucleosome organization (GO:0034723)3.38889243
39DNA replication-dependent nucleosome assembly (GO:0006335)3.38889243
40amino acid activation (GO:0043038)3.38770282
41tRNA aminoacylation (GO:0043039)3.38770282
42DNA strand elongation involved in DNA replication (GO:0006271)3.38613688
43tRNA aminoacylation for protein translation (GO:0006418)3.37662572
44negative regulation of mRNA processing (GO:0050686)3.36406203
45regulation of nuclear cell cycle DNA replication (GO:0033262)3.35602252
46ribonucleoprotein complex biogenesis (GO:0022613)3.34707655
47pore complex assembly (GO:0046931)3.33735790
48negative regulation of RNA splicing (GO:0033119)3.32035923
49DNA strand elongation (GO:0022616)3.31660509
50ribosome biogenesis (GO:0042254)3.29224632
51protein K6-linked ubiquitination (GO:0085020)3.28690037
52formation of translation preinitiation complex (GO:0001731)3.26838366
53IMP metabolic process (GO:0046040)3.26501923
54mitotic chromosome condensation (GO:0007076)3.23709083
55protein localization to chromosome (GO:0034502)3.23347239
56sister chromatid segregation (GO:0000819)3.22935614
57telomere maintenance via telomerase (GO:0007004)3.22275955
58spliceosomal complex assembly (GO:0000245)3.15676694
59histone H3-K36 demethylation (GO:0070544)3.15365359
60DNA double-strand break processing (GO:0000729)3.14981089
61rRNA processing (GO:0006364)3.14335176
62regulation of translational termination (GO:0006449)3.13701066
63spliceosomal tri-snRNP complex assembly (GO:0000244)3.13028392
64regulation of telomere maintenance via telomerase (GO:0032210)3.12976454
65DNA conformation change (GO:0071103)3.12483677
66regulation of histone H3-K4 methylation (GO:0051569)3.11906072
67RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.11624205
68DNA topological change (GO:0006265)3.11413652
69termination of RNA polymerase I transcription (GO:0006363)3.11198814
70positive regulation of chromosome segregation (GO:0051984)3.09925473
71metaphase plate congression (GO:0051310)3.07714250
72rRNA metabolic process (GO:0016072)3.07235366
73translational termination (GO:0006415)3.05216714
74viral transcription (GO:0019083)3.04860105
75regulation of nucleobase-containing compound transport (GO:0032239)3.04203655
76DNA catabolic process, exonucleolytic (GO:0000738)3.03287847
77regulation of spindle organization (GO:0090224)3.02576565
78regulation of centrosome cycle (GO:0046605)3.02411298
79ribosomal small subunit biogenesis (GO:0042274)3.01662818
80regulation of translation in response to stress (GO:0043555)3.01178712
81telomere maintenance via semi-conservative replication (GO:0032201)3.01129818
82nuclear envelope organization (GO:0006998)2.99515909
83negative regulation of mRNA metabolic process (GO:1903312)2.99472993
84RNA splicing, via transesterification reactions (GO:0000375)2.99358405
85regulation of centrosome duplication (GO:0010824)2.98815706
86regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.97936751
87V(D)J recombination (GO:0033151)2.97725667
88RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.96914274
89mRNA splicing, via spliceosome (GO:0000398)2.96914274
90chromatin assembly or disassembly (GO:0006333)2.96503503
91DNA replication-independent nucleosome organization (GO:0034724)2.96289482
92DNA replication-independent nucleosome assembly (GO:0006336)2.96289482
93response to X-ray (GO:0010165)2.95246651
94translational initiation (GO:0006413)2.94867576
95replication fork processing (GO:0031297)2.94858169
96mRNA transport (GO:0051028)2.93981910
97transcription elongation from RNA polymerase I promoter (GO:0006362)2.93273806
98meiotic chromosome segregation (GO:0045132)2.93270526
99spliceosomal snRNP assembly (GO:0000387)2.92685129
100RNA-dependent DNA replication (GO:0006278)2.92432989
101ATP-dependent chromatin remodeling (GO:0043044)2.91958471
102mRNA splice site selection (GO:0006376)2.89841614
103telomere maintenance via recombination (GO:0000722)2.89181911
104positive regulation of gene expression, epigenetic (GO:0045815)2.88147866
105nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.87878499
106histone mRNA metabolic process (GO:0008334)2.87437379
107DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.87433527
108positive regulation of histone H3-K4 methylation (GO:0051571)2.87351150
109regulation of chromatin silencing (GO:0031935)2.86418714
110maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.86390283
111negative regulation of gene silencing (GO:0060969)2.86188892
112mRNA stabilization (GO:0048255)2.86104403
113RNA stabilization (GO:0043489)2.86104403
114mitotic spindle checkpoint (GO:0071174)2.84925283
115peptidyl-histidine modification (GO:0018202)2.84598215
116regulation of mitotic spindle organization (GO:0060236)2.84268613
117spindle checkpoint (GO:0031577)2.83627848
118somatic diversification of immune receptors via somatic mutation (GO:0002566)2.82987801
119somatic hypermutation of immunoglobulin genes (GO:0016446)2.82987801
120telomere maintenance via telomere lengthening (GO:0010833)2.82826984
121ncRNA processing (GO:0034470)2.82342722
122termination of RNA polymerase II transcription (GO:0006369)2.81710067
123sister chromatid cohesion (GO:0007062)2.80864059
124spindle assembly checkpoint (GO:0071173)2.80580690
125mitotic recombination (GO:0006312)2.80296476
126transcription initiation from RNA polymerase I promoter (GO:0006361)2.79781548
127rRNA modification (GO:0000154)2.78433868
128RNA export from nucleus (GO:0006405)2.78013605
129tRNA metabolic process (GO:0006399)2.77457827
130regulation of DNA endoreduplication (GO:0032875)2.77044542
131purine nucleobase biosynthetic process (GO:0009113)2.76878417
132negative regulation of DNA repair (GO:0045738)2.76346132
133negative regulation of chromosome segregation (GO:0051985)2.76050876
134rRNA methylation (GO:0031167)2.75708664
135L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.75586056
136histone H2A monoubiquitination (GO:0035518)2.75210970
137regulation of histone methylation (GO:0031060)2.75137967
138dosage compensation (GO:0007549)2.75082164
139rRNA transcription (GO:0009303)2.74532489
140chromatin assembly (GO:0031497)2.74272111
141cellular protein complex localization (GO:0034629)2.73757079
142regulation of helicase activity (GO:0051095)2.73300559
143ncRNA metabolic process (GO:0034660)2.71949552
144transcription from mitochondrial promoter (GO:0006390)2.69606253
145postreplication repair (GO:0006301)2.69565635
146negative regulation of mitotic sister chromatid separation (GO:2000816)2.69538444
147negative regulation of sister chromatid segregation (GO:0033046)2.69538444
148negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.69538444
149negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.69538444
150negative regulation of mitotic sister chromatid segregation (GO:0033048)2.69538444
151proteasome assembly (GO:0043248)2.68425561
152rRNA catabolic process (GO:0016075)2.66943180
153negative regulation of DNA-dependent DNA replication (GO:2000104)2.65988243
154mitotic spindle assembly checkpoint (GO:0007094)2.65652580
155UDP-N-acetylglucosamine metabolic process (GO:0006047)2.65402178
156regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.65264351
157regulation of mitotic metaphase/anaphase transition (GO:0030071)2.65264351
158transcription elongation from RNA polymerase III promoter (GO:0006385)2.64525116
159termination of RNA polymerase III transcription (GO:0006386)2.64525116

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.09997192
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.35121964
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.13095807
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.49742414
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.01794634
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.99038538
7MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68052137
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.64186214
9MYC_22102868_ChIP-Seq_BL_Human2.53349680
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.51673425
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.35699877
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.29474607
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29294660
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.28829844
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.23581609
16XRN2_22483619_ChIP-Seq_HELA_Human2.11822054
17CIITA_25753668_ChIP-Seq_RAJI_Human2.10918676
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.09540365
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.04729659
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01512831
21E2F7_22180533_ChIP-Seq_HELA_Human11.5947923
22MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97937802
23YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92169474
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91324907
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.81849729
26AR_21909140_ChIP-Seq_LNCAP_Human1.81274420
27FOXP3_21729870_ChIP-Seq_TREG_Human1.80935979
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.79036059
29VDR_23849224_ChIP-Seq_CD4+_Human1.77922099
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77157575
31KDM5A_27292631_Chip-Seq_BREAST_Human1.76568405
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71642091
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71311280
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70671762
35SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.66596200
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.64716988
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63888903
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63689203
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63582912
40TTF2_22483619_ChIP-Seq_HELA_Human1.62330266
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.56682854
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55342671
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.54594548
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53902496
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47407594
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43252408
47BRD4_25478319_ChIP-Seq_HGPS_Human1.41052991
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39907789
49GABP_19822575_ChIP-Seq_HepG2_Human1.38148551
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37134348
51VDR_21846776_ChIP-Seq_THP-1_Human1.34736710
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30255203
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28726764
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28337773
55DCP1A_22483619_ChIP-Seq_HELA_Human1.26317584
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26018191
57FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24810827
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.23889797
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.23427327
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22340847
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22264849
62FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22009190
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21202129
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20475674
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20475674
66KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20475674
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20213255
68ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17574610
69EWS_26573619_Chip-Seq_HEK293_Human1.17399974
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17324779
71TCF7_22412390_ChIP-Seq_EML_Mouse1.15770657
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15569574
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.15067527
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13159902
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13030769
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11056986
77SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10944920
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10944920
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10828338
80ELK1_19687146_ChIP-ChIP_HELA_Human1.09858706
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08619773
82MYC_18940864_ChIP-ChIP_HL60_Human1.08098553
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07433362
84ELF5_23300383_ChIP-Seq_T47D_Human1.07235056
85PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06759177
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06746823
87CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06373088
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05496453
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05443379
90HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05242792
91FUS_26573619_Chip-Seq_HEK293_Human1.04464427
92NANOG_21062744_ChIP-ChIP_HESCs_Human1.03622347
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03561563
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03030481
95UTX_26944678_Chip-Seq_JUKART_Human1.02519021
96CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98760762
97TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98603452
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.98071020
99NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96208481
100TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96127878
101STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95975652
102SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95886102
103SALL1_21062744_ChIP-ChIP_HESCs_Human0.94920516
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91937444
105TFEB_21752829_ChIP-Seq_HELA_Human0.91065023
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89034584
107POU5F1_16518401_ChIP-PET_MESCs_Mouse0.88705944
108MYB_26560356_Chip-Seq_TH1_Human0.88597385
109HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88157996
110CHD1_26751641_Chip-Seq_LNCaP_Human0.88006958
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85641162
112FLI1_27457419_Chip-Seq_LIVER_Mouse0.84810745
113CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84605995
114STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84548739
115MYB_26560356_Chip-Seq_TH2_Human0.84226883
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83144543
117HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82927439
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82291447
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81581108
120ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.81439529
121NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81387145
122FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80871879
123EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.80332852
124TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.77823955
125IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.76942017
126NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.76821340
127TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73878537
128CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.73701986
129TBX5_21415370_ChIP-Seq_HL-1_Mouse0.73301865
130PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.71851680

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane5.29169733
2MP0003693_abnormal_embryo_hatching4.25760987
3MP0003111_abnormal_nucleus_morphology4.21719987
4MP0008057_abnormal_DNA_replication4.17388775
5MP0010094_abnormal_chromosome_stability4.05703284
6MP0004957_abnormal_blastocyst_morpholog3.61668886
7MP0003077_abnormal_cell_cycle3.49075174
8MP0002396_abnormal_hematopoietic_system3.12233221
9MP0008058_abnormal_DNA_repair3.01138280
10MP0006292_abnormal_olfactory_placode2.56006176
11MP0008932_abnormal_embryonic_tissue2.31765402
12MP0010352_gastrointestinal_tract_polyps2.23030571
13MP0001730_embryonic_growth_arrest2.20914626
14MP0000350_abnormal_cell_proliferation2.20181614
15MP0003806_abnormal_nucleotide_metabolis2.12968704
16MP0003890_abnormal_embryonic-extraembry2.10851426
17MP0008007_abnormal_cellular_replicative2.06524634
18MP0009697_abnormal_copulation2.01462893
19MP0003941_abnormal_skin_development1.94564235
20MP0003121_genomic_imprinting1.93641002
21MP0001672_abnormal_embryogenesis/_devel1.91102829
22MP0005380_embryogenesis_phenotype1.91102829
23MP0008877_abnormal_DNA_methylation1.83968227
24MP0001293_anophthalmia1.80571719
25MP0002877_abnormal_melanocyte_morpholog1.80477931
26MP0003183_abnormal_peptide_metabolism1.79338183
27MP0003123_paternal_imprinting1.77693986
28MP0002084_abnormal_developmental_patter1.77227607
29MP0002085_abnormal_embryonic_tissue1.73655337
30MP0005076_abnormal_cell_differentiation1.73405715
31MP0004808_abnormal_hematopoietic_stem1.71610814
32MP0001697_abnormal_embryo_size1.67174229
33MP0003984_embryonic_growth_retardation1.66911530
34MP0003763_abnormal_thymus_physiology1.65850155
35MP0004197_abnormal_fetal_growth/weight/1.65621222
36MP0002088_abnormal_embryonic_growth/wei1.62508000
37MP0000703_abnormal_thymus_morphology1.62490967
38MP0002086_abnormal_extraembryonic_tissu1.54567422
39MP0003787_abnormal_imprinting1.53059715
40MP0000490_abnormal_crypts_of1.52990147
41MP0008961_abnormal_basal_metabolism1.51985523
42MP0002080_prenatal_lethality1.51116611
43MP0004233_abnormal_muscle_weight1.48679411
44MP0002009_preneoplasia1.47936287
45MP0005623_abnormal_meninges_morphology1.42823282
46MP0000358_abnormal_cell_content/1.40002372
47MP0000383_abnormal_hair_follicle1.37697171
48MP0003786_premature_aging1.36862162
49MP0000371_diluted_coat_color1.35744221
50MP0005408_hypopigmentation1.31607025
51MP0003119_abnormal_digestive_system1.29724717
52MP0003937_abnormal_limbs/digits/tail_de1.27763044
53MP0009672_abnormal_birth_weight1.27153118
54MP0000428_abnormal_craniofacial_morphol1.26024459
55MP0000427_abnormal_hair_cycle1.24401424
56MP0000015_abnormal_ear_pigmentation1.23998272
57MP0009703_decreased_birth_body1.22835960
58MP0003303_peritoneal_inflammation1.22506944
59MP0000313_abnormal_cell_death1.21689305
60MP0005409_darkened_coat_color1.20253780
61MP0002095_abnormal_skin_pigmentation1.20049293
62MP0000569_abnormal_digit_pigmentation1.18927219
63MP0008995_early_reproductive_senescence1.17750204
64MP0002019_abnormal_tumor_incidence1.17689863
65MP0001919_abnormal_reproductive_system1.16510018
66MP0002006_tumorigenesis1.15113478
67MP0005257_abnormal_intraocular_pressure1.14655479
68MP0002398_abnormal_bone_marrow1.13938887
69MP0002060_abnormal_skin_morphology1.13758936
70MP0003136_yellow_coat_color1.13073946
71MP0003221_abnormal_cardiomyocyte_apopto1.11593734
72MP0005171_absent_coat_pigmentation1.11387313
73MP0003656_abnormal_erythrocyte_physiolo1.10197402
74MP0005174_abnormal_tail_pigmentation1.09895842
75MP0003935_abnormal_craniofacial_develop1.08376188
76MP0001545_abnormal_hematopoietic_system1.07173363
77MP0005397_hematopoietic_system_phenotyp1.07173363
78MP0008438_abnormal_cutaneous_collagen1.07146386
79MP0001661_extended_life_span1.06727986
80MP0006035_abnormal_mitochondrial_morpho1.05365387
81MP0009278_abnormal_bone_marrow1.05252744
82MP0002722_abnormal_immune_system1.04738001
83MP0000432_abnormal_head_morphology1.04717842
84MP0010234_abnormal_vibrissa_follicle1.04664043
85MP0003938_abnormal_ear_development1.04500043
86MP0010307_abnormal_tumor_latency1.04375844
87MP0004133_heterotaxia1.04307434
88MP0002092_abnormal_eye_morphology1.04109654
89MP0005501_abnormal_skin_physiology1.03990081
90MP0000465_gastrointestinal_hemorrhage1.03969762
91MP0004185_abnormal_adipocyte_glucose1.01576202
92MP0005670_abnormal_white_adipose0.99838316
93MP0001286_abnormal_eye_development0.99642739
94MP0002796_impaired_skin_barrier0.97352716
95MP0004272_abnormal_basement_membrane0.96823167
96MP0002210_abnormal_sex_determination0.95376963
97MP0005187_abnormal_penis_morphology0.94743988
98MP0000689_abnormal_spleen_morphology0.94525064
99MP0002751_abnormal_autonomic_nervous0.94189027
100MP0010030_abnormal_orbit_morphology0.93701091
101MP0003718_maternal_effect0.92787855
102MP0003861_abnormal_nervous_system0.92311990
103MP0001216_abnormal_epidermal_layer0.90488511
104MP0002075_abnormal_coat/hair_pigmentati0.85986429
105MP0005384_cellular_phenotype0.85818209
106MP0003567_abnormal_fetal_cardiomyocyte0.85472922
107MP0002160_abnormal_reproductive_system0.85406701
108MP0001915_intracranial_hemorrhage0.84936161
109MP0001145_abnormal_male_reproductive0.84433271
110MP0001873_stomach_inflammation0.83253732
111MP0000049_abnormal_middle_ear0.82550915
112MP0001186_pigmentation_phenotype0.82540450
113MP0003943_abnormal_hepatobiliary_system0.82482527
114MP0002269_muscular_atrophy0.82384350
115MP0002111_abnormal_tail_morphology0.81896558
116MP0008770_decreased_survivor_rate0.81533958
117MP0003755_abnormal_palate_morphology0.80827995
118MP0003936_abnormal_reproductive_system0.80791268
119MP0005451_abnormal_body_composition0.80468516
120MP0001849_ear_inflammation0.80246834
121MP0002166_altered_tumor_susceptibility0.79360623
122MP0000647_abnormal_sebaceous_gland0.79136199
123MP0000627_abnormal_mammary_gland0.78453988
124MP0005310_abnormal_salivary_gland0.78207861
125MP0006054_spinal_hemorrhage0.76140994
126MP0005394_taste/olfaction_phenotype0.75669304
127MP0005499_abnormal_olfactory_system0.75669304
128MP0003315_abnormal_perineum_morphology0.75592052
129MP0001191_abnormal_skin_condition0.75409685
130MP0003705_abnormal_hypodermis_morpholog0.74836571
131MP0000372_irregular_coat_pigmentation0.74487130
132MP0009053_abnormal_anal_canal0.74190791
133MP0002116_abnormal_craniofacial_bone0.73860074
134MP0004381_abnormal_hair_follicle0.73593826
135MP0002081_perinatal_lethality0.73573325
136MP0005389_reproductive_system_phenotype0.73564132
137MP0009379_abnormal_foot_pigmentation0.72555697
138MP0002249_abnormal_larynx_morphology0.72540570
139MP0010678_abnormal_skin_adnexa0.72280723
140MP0002970_abnormal_white_adipose0.72185432
141MP0003566_abnormal_cell_adhesion0.71958652
142MP0002114_abnormal_axial_skeleton0.71764153
143MP0002925_abnormal_cardiovascular_devel0.70695832
144MP0001346_abnormal_lacrimal_gland0.70597469
145MP0002429_abnormal_blood_cell0.70456453
146MP0002102_abnormal_ear_morphology0.70368533
147MP0009333_abnormal_splenocyte_physiolog0.70217093
148MP0000377_abnormal_hair_follicle0.69932325
149MP0002233_abnormal_nose_morphology0.69885187
150MP0005621_abnormal_cell_physiology0.69846626
151MP0000716_abnormal_immune_system0.68340619
152MP0005197_abnormal_uvea_morphology0.68005632
153MP0003186_abnormal_redox_activity0.66982948
154MP0000749_muscle_degeneration0.66428195
155MP0001243_abnormal_dermal_layer0.65685487
156MP0005395_other_phenotype0.63446409
157MP0010771_integument_phenotype0.63049306
158MP0000613_abnormal_salivary_gland0.62766157
159MP0001929_abnormal_gametogenesis0.61136819

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.44939016
2Medulloblastoma (HP:0002885)4.19202851
3Volvulus (HP:0002580)4.15137020
4Poikiloderma (HP:0001029)3.94710900
5Chromsome breakage (HP:0040012)3.67407969
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.61641724
7Astrocytoma (HP:0009592)3.59087321
8Abnormality of the astrocytes (HP:0100707)3.59087321
9Entropion (HP:0000621)3.34448034
10Colon cancer (HP:0003003)3.20345329
11Reticulocytopenia (HP:0001896)3.17252139
12Neoplasm of the oral cavity (HP:0100649)3.12392610
13Abnormality of the renal collecting system (HP:0004742)3.06902913
14Microvesicular hepatic steatosis (HP:0001414)3.05778907
15Prominent nose (HP:0000448)3.05082770
16Neoplasm of striated muscle (HP:0009728)3.02449654
17Abnormality of the fingertips (HP:0001211)3.02322974
18Patellar aplasia (HP:0006443)2.99746865
19Rhabdomyosarcoma (HP:0002859)2.98478517
20Glioma (HP:0009733)2.95433181
21Abnormality of the pons (HP:0007361)2.91671704
22Abnormality of chromosome stability (HP:0003220)2.88537355
23Impulsivity (HP:0100710)2.87652554
24Abnormal number of incisors (HP:0011064)2.84911803
25Long eyelashes (HP:0000527)2.83812117
26Abnormality of the labia minora (HP:0012880)2.80141182
27Birth length less than 3rd percentile (HP:0003561)2.77896489
28Proximal placement of thumb (HP:0009623)2.74798562
29Aplasia/Hypoplasia of the patella (HP:0006498)2.73119234
30Facial hemangioma (HP:0000329)2.72355052
31Squamous cell carcinoma (HP:0002860)2.67225807
32Heterotopia (HP:0002282)2.66401937
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.65438225
34Selective tooth agenesis (HP:0001592)2.64293077
35Premature graying of hair (HP:0002216)2.61703885
36Deviation of the thumb (HP:0009603)2.61322290
37Abnormality of alanine metabolism (HP:0010916)2.56710607
38Hyperalaninemia (HP:0003348)2.56710607
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.56710607
40Ureteral duplication (HP:0000073)2.53893523
41Oral leukoplakia (HP:0002745)2.47230425
42Abnormality of DNA repair (HP:0003254)2.46351594
43Myelodysplasia (HP:0002863)2.44872215
443-Methylglutaconic aciduria (HP:0003535)2.42668347
45Acute lymphatic leukemia (HP:0006721)2.39601209
46Ectopic kidney (HP:0000086)2.33692874
47Supernumerary bones of the axial skeleton (HP:0009144)2.33655738
48Increased nuchal translucency (HP:0010880)2.31400087
49Basal cell carcinoma (HP:0002671)2.30210481
50Cerebral hypomyelination (HP:0006808)2.27985856
51Meckel diverticulum (HP:0002245)2.27041703
52Large earlobe (HP:0009748)2.26702019
53Abnormality of the fetal cardiovascular system (HP:0010948)2.26597948
54Abnormal umbilical cord blood vessels (HP:0011403)2.26597948
55Single umbilical artery (HP:0001195)2.26597948
56Shawl scrotum (HP:0000049)2.25373856
57Premature ovarian failure (HP:0008209)2.23788440
58Urethral obstruction (HP:0000796)2.20675904
59Rib fusion (HP:0000902)2.20265229
60T lymphocytopenia (HP:0005403)2.19903945
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.19834268
62Deep philtrum (HP:0002002)2.17943322
63Acute myeloid leukemia (HP:0004808)2.17656923
64Rough bone trabeculation (HP:0100670)2.16581566
65Sloping forehead (HP:0000340)2.16518413
66Supernumerary spleens (HP:0009799)2.15824963
67Aplastic anemia (HP:0001915)2.13755145
68Sensory axonal neuropathy (HP:0003390)2.11912326
69Microtia (HP:0008551)2.11846799
70Biliary tract neoplasm (HP:0100574)2.11766731
71Unilateral renal agenesis (HP:0000122)2.10910420
72Cutis marmorata (HP:0000965)2.10482503
73Abnormality of the ileum (HP:0001549)2.10287296
74Abnormal protein glycosylation (HP:0012346)2.09146701
75Abnormal glycosylation (HP:0012345)2.09146701
76Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09146701
77Abnormal protein N-linked glycosylation (HP:0012347)2.09146701
78Atresia of the external auditory canal (HP:0000413)2.08385170
79Duplicated collecting system (HP:0000081)2.08113404
80Agnosia (HP:0010524)2.08072907
81Abnormality of the preputium (HP:0100587)2.07981583
82Supernumerary ribs (HP:0005815)2.07738229
83Freckling (HP:0001480)2.05124397
84Abnormality of glycolysis (HP:0004366)2.03606887
85Type I transferrin isoform profile (HP:0003642)2.03519304
86IgA deficiency (HP:0002720)2.02428193
87Choanal atresia (HP:0000453)2.02003946
88Abnormality of the columella (HP:0009929)2.00311699
89Upper limb muscle weakness (HP:0003484)1.99837363
90Abnormality of the carotid arteries (HP:0005344)1.99814612
91Bone marrow hypocellularity (HP:0005528)1.99686536
92Clubbing of toes (HP:0100760)1.98881145
93Amaurosis fugax (HP:0100576)1.97729567
94Reduced antithrombin III activity (HP:0001976)1.95593893
95Aplasia cutis congenita (HP:0001057)1.94759142
96Cafe-au-lait spot (HP:0000957)1.92122306
97Anal stenosis (HP:0002025)1.91170884
98Hypochromic microcytic anemia (HP:0004840)1.90539071
99Abnormal lung lobation (HP:0002101)1.89541348
100Abnormality of the duodenum (HP:0002246)1.89441795
101Absent radius (HP:0003974)1.87778470
102Neoplasm of the adrenal cortex (HP:0100641)1.86373460
103Increased serum pyruvate (HP:0003542)1.86161678
104Panhypogammaglobulinemia (HP:0003139)1.85004861
105Hypochromic anemia (HP:0001931)1.84646360
106Abnormality of the intrinsic pathway (HP:0010989)1.84358574
107Neoplasm of the pancreas (HP:0002894)1.84124363
108Horseshoe kidney (HP:0000085)1.83632128
109Abnormality of T cell number (HP:0011839)1.83142792
110Secondary amenorrhea (HP:0000869)1.82774842
111Delayed closure of the anterior fontanelle (HP:0001476)1.82661021
112Pallor (HP:0000980)1.82649899
113Postnatal microcephaly (HP:0005484)1.82507527
114Obsessive-compulsive behavior (HP:0000722)1.82432320
115Abnormal trabecular bone morphology (HP:0100671)1.82213643
116Septate vagina (HP:0001153)1.81663150
117Increased serum lactate (HP:0002151)1.81637138
118Progressive muscle weakness (HP:0003323)1.81143129
119Abnormality of the umbilical cord (HP:0010881)1.80269051
120Abnormality of the intervertebral disk (HP:0005108)1.80188783
121Syringomyelia (HP:0003396)1.79833306
122Spinal cord lesions (HP:0100561)1.79833306
123Attention deficit hyperactivity disorder (HP:0007018)1.79760885
124Malignant gastrointestinal tract tumors (HP:0006749)1.78220485
125Gastrointestinal carcinoma (HP:0002672)1.78220485
126Nephroblastoma (Wilms tumor) (HP:0002667)1.77928676
127Pancytopenia (HP:0001876)1.77167033
128Increased number of teeth (HP:0011069)1.76748921
129Sparse lateral eyebrow (HP:0005338)1.76257720
130Asplenia (HP:0001746)1.76203265
131Blepharitis (HP:0000498)1.75492619
132Esophageal atresia (HP:0002032)1.75055687
133Small hand (HP:0200055)1.74210808
134Absent thumb (HP:0009777)1.74077367
135Absent forearm bone (HP:0003953)1.74063494
136Aplasia involving forearm bones (HP:0009822)1.74063494
137Neoplasm of the colon (HP:0100273)1.74012071
138Lip pit (HP:0100267)1.73760394
139Small intestinal stenosis (HP:0012848)1.73307019
140Duodenal stenosis (HP:0100867)1.73307019
141Increased hepatocellular lipid droplets (HP:0006565)1.73197999
142Sparse eyelashes (HP:0000653)1.73108851
143Anal atresia (HP:0002023)1.72209653
144Combined immunodeficiency (HP:0005387)1.71894157
145Spina bifida occulta (HP:0003298)1.71531769
146Abnormality of cells of the erythroid lineage (HP:0012130)1.71492001
147Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.70956407
148Short 4th metacarpal (HP:0010044)1.70956407
149Abnormality of T cells (HP:0002843)1.70893582
150Aplasia/Hypoplasia of the earlobes (HP:0009906)1.69702924
151Macrocytic anemia (HP:0001972)1.69234685
152Abnormality of chromosome segregation (HP:0002916)1.68625160
153Breast hypoplasia (HP:0003187)1.68235832
154Abnormality of the distal phalanges of the toes (HP:0010182)1.68115191
155Skin tags (HP:0010609)1.67933302
156Melanoma (HP:0002861)1.67417454
157Subacute progressive viral hepatitis (HP:0006572)1.67412692
158Natal tooth (HP:0000695)1.67101188
159Smooth philtrum (HP:0000319)1.67040815
160Embryonal renal neoplasm (HP:0011794)1.66092718
161Aplasia/Hypoplasia of the spleen (HP:0010451)1.64841494
162Neoplasm of the small intestine (HP:0100833)1.64694594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.09330165
2CDC73.90677284
3SRPK13.65467920
4WEE13.22553710
5NEK12.94769999
6STK102.85562677
7MKNK22.67225807
8EEF2K2.60716961
9EIF2AK12.53783938
10MST42.45783229
11MAP3K102.39435720
12PBK2.23334856
13MST1R2.23163758
14TTK2.20504103
15MKNK12.13681300
16NEK22.09851943
17BRD42.06320091
18AKT31.99420482
19ACVR1B1.96446111
20PNCK1.86494203
21RPS6KA41.81731998
22CDK71.79409524
23RPS6KB21.77885178
24BUB11.77833135
25CDK41.77431068
26FRK1.74862764
27ALK1.73185774
28ATR1.63437538
29TSSK61.59809995
30BRSK21.53919161
31EIF2AK31.53183303
32TLK11.51356481
33NUAK11.51087751
34STK31.50010082
35PLK11.47306424
36ERBB41.46398485
37CHEK11.42144340
38BLK1.37995586
39ZAK1.34004702
40MAP4K11.32575231
41CCNB11.32170685
42LATS11.31324157
43STK161.30036249
44CHEK21.27585550
45BMPR1B1.26369590
46STK38L1.23656276
47GRK61.23071349
48VRK21.22665347
49NME21.22620844
50MAP3K81.20204830
51NEK91.20160916
52PLK41.18770981
53ATM1.18449491
54WNK41.14847253
55STK391.14490710
56CDK21.10871454
57AURKB1.10208441
58PAK41.10174188
59ERBB31.09968820
60PIM21.09847821
61PLK31.05234572
62MET1.03924712
63BRSK11.03793451
64TRIM280.99557417
65DYRK30.99325877
66PIM10.98497392
67TRPM70.95984254
68MELK0.94716102
69MAP3K70.92992850
70BMPR20.92621941
71WNK30.91636625
72MTOR0.88606218
73VRK10.88097176
74FLT30.86432414
75CLK10.81963048
76CDK10.81546475
77CSNK1E0.76887258
78CDK60.76275272
79TAF10.75178388
80STK380.74575852
81RAF10.73284934
82AURKA0.72364906
83MAPKAPK50.70520310
84PAK20.69888551
85CDK80.69491861
86CAMK1G0.68061042
87CSNK1D0.67765673
88NME10.66752697
89CSF1R0.64573369
90RPS6KB10.61708753
91CSNK1A1L0.60937290
92MARK20.60849112
93TGFBR10.60509837
94LATS20.59210584
95STK40.59209579
96CAMK1D0.57219087
97LRRK20.56807526
98CAMK40.56006109
99MAPK140.55041180
100TEC0.54834792
101CDK90.53966811
102CSNK2A20.53858750
103PTK20.53729118
104PDGFRA0.52082685
105PRKDC0.50545046
106NLK0.50447491
107IRAK30.50317747
108EPHA20.49459041
109MAPK70.49219507
110BCR0.48444608
111PASK0.47346317
112EIF2AK20.47150776
113TXK0.47096026
114RPS6KA50.45079358
115TAOK10.44793527
116SCYL20.44780142
117CSNK1G10.44440895
118TYRO30.44408882
119GSK3B0.44039801
120SIK20.43991148
121FES0.43018289
122YES10.42493656
123MAPK100.42004825
124FGFR10.41903532
125PDGFRB0.38683161
126STK240.38552699
127MAP3K140.38055885
128MAPK10.37620762
129ICK0.36283269
130ADRBK10.35757565
131TAOK30.35688118
132ZAP700.34053360
133CSNK2A10.32885285
134DYRK1A0.32044670
135MAPK110.31733577
136MAP3K110.31443013
137AKT10.31338092
138CSNK1G30.31253756
139BTK0.30884921
140HIPK20.30807008
141PKN20.30303515
142PTK60.30286156
143RPS6KA10.29756844
144PAK10.29717472
145ITK0.29167201

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.89506316
2DNA replication_Homo sapiens_hsa030303.77576291
3Spliceosome_Homo sapiens_hsa030403.49217016
4Mismatch repair_Homo sapiens_hsa034303.40528987
5RNA transport_Homo sapiens_hsa030133.14760121
6Homologous recombination_Homo sapiens_hsa034403.00811118
7Cell cycle_Homo sapiens_hsa041102.82118695
8One carbon pool by folate_Homo sapiens_hsa006702.73176201
9RNA polymerase_Homo sapiens_hsa030202.69625797
10Fanconi anemia pathway_Homo sapiens_hsa034602.67967274
11Ribosome_Homo sapiens_hsa030102.67036778
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.49108793
13Non-homologous end-joining_Homo sapiens_hsa034502.45520629
14Base excision repair_Homo sapiens_hsa034102.34081469
15Protein export_Homo sapiens_hsa030602.11313704
16mRNA surveillance pathway_Homo sapiens_hsa030152.10449949
17Nucleotide excision repair_Homo sapiens_hsa034202.04865326
18RNA degradation_Homo sapiens_hsa030181.93946962
19Basal transcription factors_Homo sapiens_hsa030221.78377855
20Pyrimidine metabolism_Homo sapiens_hsa002401.75280900
21p53 signaling pathway_Homo sapiens_hsa041151.37045914
22Primary immunodeficiency_Homo sapiens_hsa053401.35169036
23N-Glycan biosynthesis_Homo sapiens_hsa005101.33360876
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29859961
25Herpes simplex infection_Homo sapiens_hsa051681.25654012
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.22333679
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21734452
28Viral carcinogenesis_Homo sapiens_hsa052031.21249800
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20174374
30MicroRNAs in cancer_Homo sapiens_hsa052061.17345363
31Propanoate metabolism_Homo sapiens_hsa006401.09257680
32Colorectal cancer_Homo sapiens_hsa052101.07269934
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05339734
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05205331
35Lysine degradation_Homo sapiens_hsa003101.04124091
36Epstein-Barr virus infection_Homo sapiens_hsa051691.03990873
37Oocyte meiosis_Homo sapiens_hsa041141.00518107
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96965306
39Purine metabolism_Homo sapiens_hsa002300.96680442
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95946088
41Thyroid cancer_Homo sapiens_hsa052160.95147482
42Chronic myeloid leukemia_Homo sapiens_hsa052200.94191057
43Antigen processing and presentation_Homo sapiens_hsa046120.94023724
44HTLV-I infection_Homo sapiens_hsa051660.90831344
45Proteasome_Homo sapiens_hsa030500.89896065
46Acute myeloid leukemia_Homo sapiens_hsa052210.88599303
47Basal cell carcinoma_Homo sapiens_hsa052170.87497534
48mTOR signaling pathway_Homo sapiens_hsa041500.86505924
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86098736
50T cell receptor signaling pathway_Homo sapiens_hsa046600.85797873
51Small cell lung cancer_Homo sapiens_hsa052220.84728615
52Notch signaling pathway_Homo sapiens_hsa043300.84535861
53Pyruvate metabolism_Homo sapiens_hsa006200.84320548
54Systemic lupus erythematosus_Homo sapiens_hsa053220.80563218
55Selenocompound metabolism_Homo sapiens_hsa004500.76478084
56TGF-beta signaling pathway_Homo sapiens_hsa043500.72795034
57Circadian rhythm_Homo sapiens_hsa047100.72756572
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70505090
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.70386658
60Measles_Homo sapiens_hsa051620.69006843
61Hepatitis B_Homo sapiens_hsa051610.68498455
62B cell receptor signaling pathway_Homo sapiens_hsa046620.68453425
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68393340
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65998562
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64362683
66Prostate cancer_Homo sapiens_hsa052150.63843291
67Biosynthesis of amino acids_Homo sapiens_hsa012300.62836517
68Non-small cell lung cancer_Homo sapiens_hsa052230.61711051
69Wnt signaling pathway_Homo sapiens_hsa043100.61112054
70Pathways in cancer_Homo sapiens_hsa052000.60237128
71Hippo signaling pathway_Homo sapiens_hsa043900.58367751
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56566909
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56427120
74Hematopoietic cell lineage_Homo sapiens_hsa046400.54536201
75Apoptosis_Homo sapiens_hsa042100.51902143
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.50879242
77Vitamin B6 metabolism_Homo sapiens_hsa007500.50115351
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.47223793
79Hedgehog signaling pathway_Homo sapiens_hsa043400.44771826
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.44617557
81Pancreatic cancer_Homo sapiens_hsa052120.42265574
82Metabolic pathways_Homo sapiens_hsa011000.41363182
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41041719
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40423493
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39952400
86MAPK signaling pathway_Homo sapiens_hsa040100.39811711
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.39658828
88Alcoholism_Homo sapiens_hsa050340.39462092
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.38970977
90FoxO signaling pathway_Homo sapiens_hsa040680.38133171
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37690378
92Endometrial cancer_Homo sapiens_hsa052130.36672008
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36116757
94Choline metabolism in cancer_Homo sapiens_hsa052310.35979365
95Bladder cancer_Homo sapiens_hsa052190.35654633
96Renal cell carcinoma_Homo sapiens_hsa052110.35627627
97Melanoma_Homo sapiens_hsa052180.35550799
98Glutathione metabolism_Homo sapiens_hsa004800.35005816
99Dorso-ventral axis formation_Homo sapiens_hsa043200.34486849
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33712792
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33252470
102Influenza A_Homo sapiens_hsa051640.33113633
103Proteoglycans in cancer_Homo sapiens_hsa052050.32622949
104Sulfur relay system_Homo sapiens_hsa041220.32434851
105Adherens junction_Homo sapiens_hsa045200.31053974
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31050892
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30839146
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30208967
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29633864
110Carbon metabolism_Homo sapiens_hsa012000.29231184
111Sulfur metabolism_Homo sapiens_hsa009200.29162604
112ErbB signaling pathway_Homo sapiens_hsa040120.29096859
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28989509
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28384407
115Hepatitis C_Homo sapiens_hsa051600.27965173
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27245575
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26435059
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26039460
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24609236
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23676646
121Prolactin signaling pathway_Homo sapiens_hsa049170.22593412
122Huntingtons disease_Homo sapiens_hsa050160.22504692
123Viral myocarditis_Homo sapiens_hsa054160.20904480
124Folate biosynthesis_Homo sapiens_hsa007900.20065933
125Steroid biosynthesis_Homo sapiens_hsa001000.19948212
126Platelet activation_Homo sapiens_hsa046110.19820160
127Sphingolipid metabolism_Homo sapiens_hsa006000.19366182
128Vibrio cholerae infection_Homo sapiens_hsa051100.19088521
129Shigellosis_Homo sapiens_hsa051310.19027743
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18660509
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18590430
132Glioma_Homo sapiens_hsa052140.18299532
133Inositol phosphate metabolism_Homo sapiens_hsa005620.18001296
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.16485389
135ECM-receptor interaction_Homo sapiens_hsa045120.15762559
136Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.14544750

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