DIO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein is expressed predominantly in the liver and kidney and provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.39208023
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.39208023
3L-phenylalanine metabolic process (GO:0006558)7.05408395
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.05408395
5exogenous drug catabolic process (GO:0042738)6.98256902
6epoxygenase P450 pathway (GO:0019373)6.94736069
7aromatic amino acid family catabolic process (GO:0009074)6.64109636
8phenylpropanoid metabolic process (GO:0009698)6.27903894
9indole-containing compound catabolic process (GO:0042436)5.94565856
10indolalkylamine catabolic process (GO:0046218)5.94565856
11tryptophan catabolic process (GO:0006569)5.94565856
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.92510022
13kynurenine metabolic process (GO:0070189)5.79993992
14omega-hydroxylase P450 pathway (GO:0097267)5.76377727
15tryptophan metabolic process (GO:0006568)5.63747348
16bile acid biosynthetic process (GO:0006699)5.61847894
17oxidative demethylation (GO:0070989)5.56401885
18urea cycle (GO:0000050)5.48963686
19urea metabolic process (GO:0019627)5.48963686
20alpha-linolenic acid metabolic process (GO:0036109)5.38663012
21glyoxylate metabolic process (GO:0046487)5.37323188
22high-density lipoprotein particle remodeling (GO:0034375)5.25905612
23peptidyl-glutamic acid carboxylation (GO:0017187)5.11798444
24protein carboxylation (GO:0018214)5.11798444
25hormone catabolic process (GO:0042447)5.11663919
26cysteine metabolic process (GO:0006534)5.07153909
27sulfur amino acid catabolic process (GO:0000098)5.06525422
28negative regulation of fibrinolysis (GO:0051918)5.05919622
29nitrogen cycle metabolic process (GO:0071941)5.05552107
30regulation of fibrinolysis (GO:0051917)4.99216153
31bile acid metabolic process (GO:0008206)4.90260864
32complement activation, alternative pathway (GO:0006957)4.87229638
33negative regulation of hemostasis (GO:1900047)4.83983932
34negative regulation of blood coagulation (GO:0030195)4.83983932
35aromatic amino acid family metabolic process (GO:0009072)4.82523152
36regulation of plasminogen activation (GO:0010755)4.79304526
37serine family amino acid catabolic process (GO:0009071)4.77279732
38regulation of protein activation cascade (GO:2000257)4.74806741
39cellular ketone body metabolic process (GO:0046950)4.67626062
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.66751178
41tyrosine metabolic process (GO:0006570)4.63241018
42regulation of cholesterol esterification (GO:0010872)4.62895690
43imidazole-containing compound metabolic process (GO:0052803)4.61030189
44alkaloid metabolic process (GO:0009820)4.59710005
45reverse cholesterol transport (GO:0043691)4.58653427
46homocysteine metabolic process (GO:0050667)4.53281346
47acylglycerol homeostasis (GO:0055090)4.52384651
48triglyceride homeostasis (GO:0070328)4.52384651
49regulation of triglyceride catabolic process (GO:0010896)4.51697197
50lysine metabolic process (GO:0006553)4.50408393
51lysine catabolic process (GO:0006554)4.50408393
52amino-acid betaine metabolic process (GO:0006577)4.49208484
53alpha-amino acid catabolic process (GO:1901606)4.46664642
54macromolecular complex remodeling (GO:0034367)4.46278202
55plasma lipoprotein particle remodeling (GO:0034369)4.46278202
56protein-lipid complex remodeling (GO:0034368)4.46278202
57regulation of complement activation (GO:0030449)4.43261608
58phospholipid efflux (GO:0033700)4.42930323
59negative regulation of coagulation (GO:0050819)4.39729396
60negative regulation of wound healing (GO:0061045)4.39445036
61bile acid and bile salt transport (GO:0015721)4.37994155
62negative regulation of sterol transport (GO:0032372)4.36947770
63negative regulation of cholesterol transport (GO:0032375)4.36947770
64steroid catabolic process (GO:0006706)4.36619471
65regulation of lipoprotein particle clearance (GO:0010984)4.33203649
66heme transport (GO:0015886)4.32322619
67indolalkylamine metabolic process (GO:0006586)4.27851302
68negative regulation of protein activation cascade (GO:2000258)4.20734105
69ethanol metabolic process (GO:0006067)4.17167212
70coenzyme catabolic process (GO:0009109)4.16328443
71protein activation cascade (GO:0072376)4.14033636
72cellular amino acid catabolic process (GO:0009063)4.12405702
73amine catabolic process (GO:0009310)4.08052341
74cellular biogenic amine catabolic process (GO:0042402)4.08052341
75plasma lipoprotein particle clearance (GO:0034381)4.05935141
76cellular glucuronidation (GO:0052695)4.04318099
77ketone body metabolic process (GO:1902224)4.03718905
78glutamate metabolic process (GO:0006536)4.03671708
79glycine metabolic process (GO:0006544)4.02997116
80positive regulation of blood coagulation (GO:0030194)4.02989513
81positive regulation of hemostasis (GO:1900048)4.02989513
82benzene-containing compound metabolic process (GO:0042537)4.02728926
83cholesterol efflux (GO:0033344)4.02366686
84regulation of bile acid biosynthetic process (GO:0070857)3.99168105
85cellular modified amino acid catabolic process (GO:0042219)3.94328789
86arginine metabolic process (GO:0006525)3.89662086
87polyketide metabolic process (GO:0030638)3.88226280
88doxorubicin metabolic process (GO:0044598)3.88226280
89daunorubicin metabolic process (GO:0044597)3.88226280
90drug catabolic process (GO:0042737)3.87783132
91serine family amino acid metabolic process (GO:0009069)3.87538484
92negative regulation of complement activation (GO:0045916)3.84456332
93* thyroid hormone generation (GO:0006590)3.79814966
94fat-soluble vitamin biosynthetic process (GO:0042362)3.74550235
95plasma lipoprotein particle assembly (GO:0034377)3.74236302
96positive regulation of coagulation (GO:0050820)3.74054619
97ethanol oxidation (GO:0006069)3.73820268
98negative regulation of fatty acid biosynthetic process (GO:0045717)3.73052326
99acute-phase response (GO:0006953)3.72128930
100regulation of humoral immune response (GO:0002920)3.71159589
101S-adenosylmethionine metabolic process (GO:0046500)3.69366721
102dicarboxylic acid biosynthetic process (GO:0043650)3.68738677
103fibrinolysis (GO:0042730)3.67034710
104low-density lipoprotein particle remodeling (GO:0034374)3.66426024
105primary alcohol catabolic process (GO:0034310)3.66201685
106drug transmembrane transport (GO:0006855)3.65536008
107complement activation (GO:0006956)3.64651377
108cholesterol homeostasis (GO:0042632)3.63809346
109organic acid catabolic process (GO:0016054)3.63275129
110carboxylic acid catabolic process (GO:0046395)3.63275129
111proline metabolic process (GO:0006560)3.62575737
112urate metabolic process (GO:0046415)3.62367762
113short-chain fatty acid metabolic process (GO:0046459)3.62197237
114aldehyde catabolic process (GO:0046185)3.60542991
115regulation of cholesterol homeostasis (GO:2000188)3.59705790
116sterol homeostasis (GO:0055092)3.58400433
117glucuronate metabolic process (GO:0019585)3.58180104
118uronic acid metabolic process (GO:0006063)3.58180104
119positive regulation of lipoprotein lipase activity (GO:0051006)3.56062427
120positive regulation of triglyceride lipase activity (GO:0061365)3.56062427
121aminoglycoside antibiotic metabolic process (GO:0030647)3.54637729
122negative regulation of lipase activity (GO:0060192)3.53954267
123cofactor catabolic process (GO:0051187)3.53536062
124xenobiotic metabolic process (GO:0006805)3.53390864
125carnitine metabolic process (GO:0009437)3.51360790
126cytolysis (GO:0019835)3.51299644
127serine family amino acid biosynthetic process (GO:0009070)3.50779500
128phospholipid homeostasis (GO:0055091)3.50440824
129positive regulation of lipid catabolic process (GO:0050996)3.49415306
130flavonoid metabolic process (GO:0009812)3.48270138
131blood coagulation, intrinsic pathway (GO:0007597)3.45754635
132very-low-density lipoprotein particle assembly (GO:0034379)3.44667732
133intestinal cholesterol absorption (GO:0030299)3.43864255
134complement activation, classical pathway (GO:0006958)3.43448872
135acetyl-CoA metabolic process (GO:0006084)3.42450599
136drug metabolic process (GO:0017144)3.41764178
137lipoprotein metabolic process (GO:0042157)3.41253208

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.19331989
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.98071384
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.62820037
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.38378614
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.09239823
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.73104363
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.63993163
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.93748755
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.74373024
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2552822
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.97855796
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94289622
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94151857
14GATA1_22025678_ChIP-Seq_K562_Human1.85638408
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.64602225
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60242135
17CLOCK_20551151_ChIP-Seq_293T_Human1.59840984
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43802494
19* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40565026
20HTT_18923047_ChIP-ChIP_STHdh_Human1.30067481
21SOX2_27498859_Chip-Seq_STOMACH_Mouse1.28020189
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.13844548
23* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06988579
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05754777
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05394401
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02472487
27GATA4_25053715_ChIP-Seq_YYC3_Human1.02060913
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97853078
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97124109
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93096101
31NFE2_27457419_Chip-Seq_LIVER_Mouse0.91547824
32BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89714079
33SOX2_21211035_ChIP-Seq_LN229_Human0.89246597
34ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88967843
35* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.88643477
36PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87385683
37SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85720425
38* HNFA_21074721_ChIP-Seq_CACO-2_Human0.82711410
39SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82543848
40* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.81731085
41KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80602894
42IRF1_19129219_ChIP-ChIP_H3396_Human0.80221246
43BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.79870048
44* ESR2_21235772_ChIP-Seq_MCF-7_Human0.79093277
45* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78701941
46RARA_24833708_ChIP-Seq_LIVER_Mouse0.78170018
47IRF8_22096565_ChIP-ChIP_GC-B_Human0.77988652
48* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.77023690
49ESR1_21235772_ChIP-Seq_MCF-7_Human0.76338378
50AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76073198
51EZH2_27294783_Chip-Seq_NPCs_Mouse0.75907975
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.75854551
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.75842028
54TCF4_18268006_ChIP-ChIP_LS174T_Human0.74202235
55* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.73861301
56* PHF8_20622853_ChIP-Seq_HELA_Human0.73430718
57TP53_18474530_ChIP-ChIP_U2OS_Human0.73167518
58RARG_19884340_ChIP-ChIP_MEFs_Mouse0.72667655
59* GATA6_21074721_ChIP-Seq_CACO-2_Human0.72348841
60ER_23166858_ChIP-Seq_MCF-7_Human0.72062705
61FOXA1_25552417_ChIP-Seq_VCAP_Human0.71441635
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.70653124
63SUZ12_27294783_Chip-Seq_NPCs_Mouse0.69978594
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.69906101
65NRF2_20460467_ChIP-Seq_MEFs_Mouse0.69906101
66RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69677337
67GATA3_21867929_ChIP-Seq_CD8_Mouse0.69173433
68SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.68110260
69ELF1_20517297_ChIP-Seq_JURKAT_Human0.67531695
70SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67256059
71RARB_24833708_ChIP-Seq_LIVER_Mouse0.67108043
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.67044451
73JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.66964909
74CBX2_22325352_ChIP-Seq_293T-Rex_Human0.66259425
75SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.66179742
76PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.65782179
77* NFYA_21822215_ChIP-Seq_K562_Human0.64545844
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.64303698
79CRX_20693478_ChIP-Seq_RETINA_Mouse0.63283620
80STAT1_17558387_ChIP-Seq_HELA_Human0.63059118
81PIAS1_25552417_ChIP-Seq_VCAP_Human0.62977613
82AR_20517297_ChIP-Seq_VCAP_Human0.62023232
83EGR1_19032775_ChIP-ChIP_M12_Human0.61394511
84RUNX1_27457419_Chip-Seq_LIVER_Mouse0.61328564
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.61187308
86FOXO3_23340844_ChIP-Seq_DLD1_Human0.60788134
87RAC3_21632823_ChIP-Seq_H3396_Human0.60713769
88FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.60157429
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.59827279
90LXR_22292898_ChIP-Seq_THP-1_Human0.59145814
91ESRRB_18555785_Chip-Seq_ESCs_Mouse0.58873157
92NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.58482018
93ESR1_15608294_ChIP-ChIP_MCF-7_Human0.57998719
94SOX2_20726797_ChIP-Seq_SW620_Human0.57942318
95FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.57863557
96OCT4_21477851_ChIP-Seq_ESCs_Mouse0.57162163
97PCGF2_27294783_Chip-Seq_NPCs_Mouse0.57058033
98SMAD1_18555785_Chip-Seq_ESCs_Mouse0.56930009
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.56489945
100CEBPB_22108803_ChIP-Seq_LS180_Human0.56345561
101GATA6_25053715_ChIP-Seq_YYC3_Human0.55269964
102NANOG_19829295_ChIP-Seq_ESCs_Human0.53078545
103SOX2_19829295_ChIP-Seq_ESCs_Human0.53078545
104ERG_20517297_ChIP-Seq_VCAP_Human0.52843089
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.52493536
106ZFX_18555785_Chip-Seq_ESCs_Mouse0.52373079
107ERG_21242973_ChIP-ChIP_JURKAT_Human0.52260531
108MYC_19915707_ChIP-ChIP_AK7_Human0.52157463
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.52008367
110GATA3_21878914_ChIP-Seq_MCF-7_Human0.51546680
111SA1_27219007_Chip-Seq_Bcells_Human0.51537043
112CBP_21632823_ChIP-Seq_H3396_Human0.51043691
113CDX2_20551321_ChIP-Seq_CACO-2_Human0.50800848
114PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.50766160
115BCAT_22108803_ChIP-Seq_LS180_Human0.50375461
116* ESET_19884257_ChIP-Seq_ESCs_Mouse0.50305574
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.50175885
118* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.50139108
119EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.48914564
120FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.48136182
121GATA1_19941826_ChIP-Seq_K562_Human0.47655226
122GATA3_24758297_ChIP-Seq_MCF-7_Human0.47368031
123NCOR_22424771_ChIP-Seq_293T_Human0.47059466
124* P53_21459846_ChIP-Seq_SAOS-2_Human0.46894415
125PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46735462
126* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46203618
127ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.46130862
128MYC_27129775_Chip-Seq_CORNEA_Mouse0.43784125
129CDX2_22108803_ChIP-Seq_LS180_Human0.43420458
130P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.43252405
131* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43243943
132ESR1_20079471_ChIP-ChIP_T-47D_Human0.42993810
133GATA2_19941826_ChIP-Seq_K562_Human0.42780289
134TAF2_19829295_ChIP-Seq_ESCs_Human0.42765259
135GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.42175843
136CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.41522485
137PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.41451552
138ETV2_25802403_ChIP-Seq_MESCs_Mouse0.41128776

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.11329657
2MP0005360_urolithiasis7.15380576
3MP0005085_abnormal_gallbladder_physiolo6.22988663
4MP0005365_abnormal_bile_salt6.00661210
5MP0008875_abnormal_xenobiotic_pharmacok5.14274899
6MP0003806_abnormal_nucleotide_metabolis4.07668357
7MP0003252_abnormal_bile_duct3.87202177
8MP0010329_abnormal_lipoprotein_level3.42923761
9MP0003195_calcinosis3.21984233
10MP0009840_abnormal_foam_cell3.10720824
11MP0005332_abnormal_amino_acid2.77903126
12MP0005083_abnormal_biliary_tract2.74951230
13MP0001666_abnormal_nutrient_absorption2.66184761
14MP0002138_abnormal_hepatobiliary_system2.29377534
15MP0004019_abnormal_vitamin_homeostasis2.15203280
16MP0000609_abnormal_liver_physiology2.12817468
17MP0003191_abnormal_cellular_cholesterol2.09761454
18* MP0002118_abnormal_lipid_homeostasis2.08015885
19MP0002254_reproductive_system_inflammat1.86889363
20MP0005319_abnormal_enzyme/_coenzyme1.77112453
21* MP0003868_abnormal_feces_composition1.76377820
22MP0001764_abnormal_homeostasis1.68882580
23* MP0009643_abnormal_urine_homeostasis1.53060576
24MP0005584_abnormal_enzyme/coenzyme_acti1.50718277
25MP0005451_abnormal_body_composition1.36296244
26MP0005647_abnormal_sex_gland1.32110325
27MP0009697_abnormal_copulation1.31063840
28MP0004043_abnormal_pH_regulation1.28622237
29* MP0002876_abnormal_thyroid_physiology1.22016025
30MP0005187_abnormal_penis_morphology1.14622486
31MP0000598_abnormal_liver_morphology1.11836699
32MP0005636_abnormal_mineral_homeostasis1.11744303
33MP0003186_abnormal_redox_activity1.10527431
34MP0003879_abnormal_hair_cell1.03853944
35MP0002078_abnormal_glucose_homeostasis1.03095654
36MP0009764_decreased_sensitivity_to1.00723688
37MP0003011_delayed_dark_adaptation0.99402589
38MP0005220_abnormal_exocrine_pancreas0.98627129
39MP0001915_intracranial_hemorrhage0.97534622
40MP0002132_abnormal_respiratory_system0.96763316
41MP0003656_abnormal_erythrocyte_physiolo0.94427704
42* MP0009642_abnormal_blood_homeostasis0.92143390
43MP0001756_abnormal_urination0.90919409
44MP0009763_increased_sensitivity_to0.90217325
45MP0003705_abnormal_hypodermis_morpholog0.88757291
46MP0000604_amyloidosis0.88226002
47MP0006036_abnormal_mitochondrial_physio0.87801740
48MP0008469_abnormal_protein_level0.86553791
49MP0005535_abnormal_body_temperature0.80297806
50MP0005334_abnormal_fat_pad0.77192521
51MP0005408_hypopigmentation0.76651709
52MP0009765_abnormal_xenobiotic_induced0.76262841
53MP0002971_abnormal_brown_adipose0.70863498
54MP0005376_homeostasis/metabolism_phenot0.70537247
55MP0005670_abnormal_white_adipose0.70138890
56MP0005084_abnormal_gallbladder_morpholo0.69938082
57MP0010368_abnormal_lymphatic_system0.67017605
58MP0002837_dystrophic_cardiac_calcinosis0.66505909
59MP0001944_abnormal_pancreas_morphology0.66366277
60MP0005448_abnormal_energy_balance0.62753822
61MP0010386_abnormal_urinary_bladder0.62144480
62MP0001661_extended_life_span0.61395481
63MP0004264_abnormal_extraembryonic_tissu0.60712336
64* MP0003953_abnormal_hormone_level0.60486651
65MP0000639_abnormal_adrenal_gland0.60147065
66MP0002090_abnormal_vision0.59199605
67MP0001348_abnormal_lacrimal_gland0.58637759
68MP0002136_abnormal_kidney_physiology0.56820498
69MP0005266_abnormal_metabolism0.56249634
70MP0002928_abnormal_bile_duct0.55717397
71MP0004782_abnormal_surfactant_physiolog0.55638524
72MP0002693_abnormal_pancreas_physiology0.54804449
73MP0004130_abnormal_muscle_cell0.54049721
74MP0005058_abnormal_lysosome_morphology0.53128557
75MP0000579_abnormal_nail_morphology0.53002843
76MP0009053_abnormal_anal_canal0.52091173
77MP0002089_abnormal_postnatal_growth/wei0.50945832
78MP0003690_abnormal_glial_cell0.50797685
79MP0000538_abnormal_urinary_bladder0.48059558
80MP0001765_abnormal_ion_homeostasis0.47939889
81MP0003329_amyloid_beta_deposits0.46219514
82MP0000681_abnormal_thyroid_gland0.44231919
83MP0000678_abnormal_parathyroid_gland0.44156643
84MP0006082_CNS_inflammation0.43985666
85MP0000230_abnormal_systemic_arterial0.43523527
86MP0001881_abnormal_mammary_gland0.42830763
87MP0005395_other_phenotype0.42408525
88MP0006035_abnormal_mitochondrial_morpho0.42242988
89MP0002877_abnormal_melanocyte_morpholog0.41237658
90MP0003959_abnormal_lean_body0.41101160
91* MP0003638_abnormal_response/metabolism_0.39809018
92MP0009780_abnormal_chondrocyte_physiolo0.39447828
93MP0005464_abnormal_platelet_physiology0.38971630
94MP0000249_abnormal_blood_vessel0.38730694
95MP0009672_abnormal_birth_weight0.38633761
96MP0003183_abnormal_peptide_metabolism0.37622042
97MP0003941_abnormal_skin_development0.37267559
98MP0003300_gastrointestinal_ulcer0.37099829
99MP0002249_abnormal_larynx_morphology0.36858065
100MP0002168_other_aberrant_phenotype0.35276199
101MP0003075_altered_response_to0.35245624
102MP0008874_decreased_physiological_sensi0.34794903
103MP0002282_abnormal_trachea_morphology0.33418817
104MP0002909_abnormal_adrenal_gland0.33358407
105MP0005666_abnormal_adipose_tissue0.33027724
106MP0002896_abnormal_bone_mineralization0.32604488
107MP0002970_abnormal_white_adipose0.32443407
108MP0010234_abnormal_vibrissa_follicle0.32396598
109MP0002822_catalepsy0.32153260
110MP0005248_abnormal_Harderian_gland0.31879962
111MP0002796_impaired_skin_barrier0.31831045
112MP0000685_abnormal_immune_system0.31601726
113MP0008872_abnormal_physiological_respon0.31382965
114MP0003718_maternal_effect0.29306283
115MP0000920_abnormal_myelination0.28465761
116MP0005197_abnormal_uvea_morphology0.27135386
117MP0005167_abnormal_blood-brain_barrier0.26143057
118MP0005164_abnormal_response_to0.26064871
119MP0001501_abnormal_sleep_pattern0.25485628
120MP0005645_abnormal_hypothalamus_physiol0.23373763
121MP0001485_abnormal_pinna_reflex0.22059264
122MP0003172_abnormal_lysosome_physiology0.20766750
123MP0004272_abnormal_basement_membrane0.20062078
124MP0004885_abnormal_endolymph0.19756263
125MP0005023_abnormal_wound_healing0.19721176
126MP0001324_abnormal_eye_pigmentation0.19489777
127MP0008873_increased_physiological_sensi0.19436962
128MP0000566_synostosis0.18784796
129MP0004883_abnormal_blood_vessel0.18769613
130MP0001845_abnormal_inflammatory_respons0.17609726

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.44028024
2Intrahepatic cholestasis (HP:0001406)7.04332813
3Deep venous thrombosis (HP:0002625)6.67431507
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.37108916
5Prolonged partial thromboplastin time (HP:0003645)6.22919496
6Hypobetalipoproteinemia (HP:0003563)5.91816362
7Xanthomatosis (HP:0000991)5.86869353
8Hyperlipoproteinemia (HP:0010980)5.20755677
9Complement deficiency (HP:0004431)4.70294955
10Hypoglycemic coma (HP:0001325)4.42214164
11Joint hemorrhage (HP:0005261)4.41813203
12Hypolipoproteinemia (HP:0010981)4.40451864
13Hyperammonemia (HP:0001987)4.38246382
14Ketosis (HP:0001946)4.37396580
15Abnormality of the common coagulation pathway (HP:0010990)4.25368058
16Epidermoid cyst (HP:0200040)4.24509006
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.23231061
18Reduced antithrombin III activity (HP:0001976)4.18871483
19Hyperglycinemia (HP:0002154)4.16655247
20Fat malabsorption (HP:0002630)4.05665691
21Hyperglycinuria (HP:0003108)4.02466176
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.99290187
23Abnormality of the intrinsic pathway (HP:0010989)3.98773533
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.98486195
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.97692010
26Abnormality of methionine metabolism (HP:0010901)3.94476679
27Conjugated hyperbilirubinemia (HP:0002908)3.84389074
28Hypoalphalipoproteinemia (HP:0003233)3.83953134
29Thyroid-stimulating hormone excess (HP:0002925)3.83671975
30Abnormality of glycine metabolism (HP:0010895)3.82928799
31Abnormality of serine family amino acid metabolism (HP:0010894)3.82928799
32Ketoacidosis (HP:0001993)3.60964795
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.46353004
34Abnormality of fatty-acid metabolism (HP:0004359)3.40657558
35Abnormality of complement system (HP:0005339)3.37668699
36Abnormality of pyrimidine metabolism (HP:0004353)3.37437460
37Delayed CNS myelination (HP:0002188)3.34517787
38Hypercholesterolemia (HP:0003124)3.34151294
39Osteomalacia (HP:0002749)3.27639008
40Hyperbilirubinemia (HP:0002904)3.26846291
41Hypoglycemic seizures (HP:0002173)3.24882173
42Abnormality of nucleobase metabolism (HP:0010932)3.02538072
43Steatorrhea (HP:0002570)2.98507217
44Nephritis (HP:0000123)2.98129843
45* Goiter (HP:0000853)2.96922982
46Hepatocellular carcinoma (HP:0001402)2.89745562
47Abnormality of purine metabolism (HP:0004352)2.85088378
48Hyperinsulinemic hypoglycemia (HP:0000825)2.83342098
49Abnormality of serum amino acid levels (HP:0003112)2.82332266
50Gout (HP:0001997)2.76332987
51Metabolic acidosis (HP:0001942)2.76296367
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.69214314
53Dicarboxylic aciduria (HP:0003215)2.69214314
54Hemorrhage of the eye (HP:0011885)2.67294385
55Lethargy (HP:0001254)2.61811853
56Skin nodule (HP:0200036)2.61335403
57Vascular calcification (HP:0004934)2.56388515
58Irritability (HP:0000737)2.55452839
59Mitral stenosis (HP:0001718)2.54772993
60Myocardial infarction (HP:0001658)2.53053697
61Late onset (HP:0003584)2.52667708
62Hyperphosphaturia (HP:0003109)2.52456726
63Abnormal gallbladder morphology (HP:0012437)2.51367996
64Systemic lupus erythematosus (HP:0002725)2.50022703
65Hypochromic microcytic anemia (HP:0004840)2.48358327
66Pulmonary embolism (HP:0002204)2.47117889
67Spontaneous abortion (HP:0005268)2.42903424
68Bile duct proliferation (HP:0001408)2.42547730
69Abnormal biliary tract physiology (HP:0012439)2.42547730
70Hyperglycemia (HP:0003074)2.42220975
71Generalized aminoaciduria (HP:0002909)2.42090659
72Symptomatic seizures (HP:0011145)2.39807756
73Cholelithiasis (HP:0001081)2.34856676
74Purpura (HP:0000979)2.31959883
75Cerebral edema (HP:0002181)2.31622316
76Brushfield spots (HP:0001088)2.28987807
77Malnutrition (HP:0004395)2.28446629
78Hydroxyprolinuria (HP:0003080)2.26043694
79Abnormality of proline metabolism (HP:0010907)2.26043694
80Cardiovascular calcification (HP:0011915)2.25217363
81Enlarged kidneys (HP:0000105)2.24990599
82Acanthocytosis (HP:0001927)2.23459635
83Alkalosis (HP:0001948)2.23248114
84Arthropathy (HP:0003040)2.21686578
85Abnormality of the Achilles tendon (HP:0005109)2.20400805
86Neonatal onset (HP:0003623)2.20350002
87Abnormal pupillary function (HP:0007686)2.13012895
88Recurrent gram-negative bacterial infections (HP:0005420)2.11570744
89Pancreatitis (HP:0001733)2.11177132
90Abnormal urine phosphate concentration (HP:0012599)2.08375014
91Sensorimotor neuropathy (HP:0007141)2.08262389
92Esophageal varix (HP:0002040)2.07908257
93Opisthotonus (HP:0002179)2.07842017
94Glomerulonephritis (HP:0000099)2.07472173
95Spastic diplegia (HP:0001264)2.07025231
96Vomiting (HP:0002013)2.07021796
97Fair hair (HP:0002286)2.04482794
98Abnormality of the gallbladder (HP:0005264)2.02075506
99Menorrhagia (HP:0000132)2.01117198
100Abnormal gallbladder physiology (HP:0012438)2.00339204
101Cholecystitis (HP:0001082)2.00339204
102Thrombophlebitis (HP:0004418)2.00330393
103Amyloidosis (HP:0011034)1.98742065
104Abnormal enzyme/coenzyme activity (HP:0012379)1.97819465
105Abnormality of transition element cation homeostasis (HP:0011030)1.95078037
106Retinal atrophy (HP:0001105)1.94757024
107Abnormality of vitamin metabolism (HP:0100508)1.93390865
108Renal cortical cysts (HP:0000803)1.93211905
109Gingival bleeding (HP:0000225)1.92724785
110Rickets (HP:0002748)1.90620048
111Proximal tubulopathy (HP:0000114)1.88867321
112Glycosuria (HP:0003076)1.87946122
113Abnormality of urine glucose concentration (HP:0011016)1.87946122
114Increased purine levels (HP:0004368)1.87169584
115Hyperuricemia (HP:0002149)1.87169584
116Abnormality of iron homeostasis (HP:0011031)1.85485387
117Neonatal hypoglycemia (HP:0001998)1.85139233
118Poikilocytosis (HP:0004447)1.83372347
119Elevated alkaline phosphatase (HP:0003155)1.82780918
120Atrioventricular block (HP:0001678)1.80289323
121Lower limb hyperreflexia (HP:0002395)1.78208113
122Bifid scrotum (HP:0000048)1.77239021
123Abnormality of alkaline phosphatase activity (HP:0004379)1.76446743
124Hypophosphatemic rickets (HP:0004912)1.75158294
125Gangrene (HP:0100758)1.75112026
126Urinary glycosaminoglycan excretion (HP:0003541)1.72054470
127Mucopolysacchariduria (HP:0008155)1.72054470
128Increased serum ferritin (HP:0003281)1.69170213
129Paraparesis (HP:0002385)1.66241136
130Abnormal hair laboratory examination (HP:0003328)1.63319704

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.41289787
2ERN14.43243190
3INSRR4.34274684
4FGFR44.03328027
5SIK13.80100146
6TAOK33.38928361
7MAP3K122.86672746
8FRK2.50565633
9ERBB42.24358245
10PRKCG2.15807522
11ADRBK22.05330311
12MAPK152.02940626
13FLT32.02430019
14MUSK1.99933908
15MAP2K21.95917359
16IRAK31.93755416
17MST1R1.80346783
18PTK61.79189536
19MAP3K141.69659233
20TRIB31.67936642
21MAP2K41.66608182
22PIK3CG1.62519566
23PKN21.56640901
24MAP3K101.52690420
25LATS11.51950068
26DYRK1B1.48349666
27MAPK111.43080199
28TYK21.42979070
29PIK3CA1.32697364
30EPHA31.29954703
31PDK21.29606600
32DAPK21.28230932
33JAK21.27532381
34MYLK1.22170929
35MAP3K71.14892067
36ARAF1.14843377
37PINK11.13315916
38PRKAA21.12443787
39CDK121.12432574
40MAP3K21.04710287
41FGFR21.04560486
42BRAF1.03734567
43EPHB11.01239351
44ABL20.99901348
45NEK90.99872722
46TAOK20.98368266
47AKT30.97924344
48MAP3K30.95729777
49PTK20.95034436
50EIF2AK10.94844148
51TBK10.94740517
52WNK40.94681691
53IRAK10.93750845
54SCYL20.91244053
55TESK20.90891762
56PRKCZ0.89125053
57PRPF4B0.88805613
58STK38L0.88187708
59JAK10.88085945
60IRAK20.86631393
61KDR0.86566765
62MET0.86357457
63SGK10.84890154
64CSNK1D0.83778251
65MAPKAPK30.78864670
66WNK30.77196616
67PIM20.75872059
68MAP3K50.75048516
69PRKACG0.74537467
70EPHA40.72091433
71PRKG10.71392399
72PDPK10.70018493
73MAP3K110.69360487
74STK380.68417970
75PRKAA10.68297340
76GSK3A0.66928352
77ERBB20.65944736
78MAP3K10.65827783
79PRKCB0.65218725
80MAP2K10.63464380
81RPS6KA30.60054289
82NTRK30.59852918
83MAPK40.59654759
84CSNK1A10.58651163
85TIE10.58647795
86GRK60.57886364
87CSK0.57387291
88MAP2K30.55646669
89CAMK2G0.55630411
90IKBKE0.55221073
91SGK30.55174580
92MAP2K60.53428524
93PRKCE0.53032522
94ACVR1B0.51673899
95MAP3K130.51007873
96RIPK10.50262874
97NLK0.49811367
98PAK30.49681572
99PBK0.49608913
100FGFR30.49058218
101RET0.47951851
102ITK0.46886010
103PRKCQ0.45370239
104NTRK10.44902925
105CSNK2A20.44781091
106CSNK1E0.44022364
107IGF1R0.44013819
108CASK0.43901475
109CHUK0.42119692
110CDK60.41817754
111PRKACB0.39985447
112CAMK1G0.39567358
113IRAK40.39294212
114ICK0.38757862
115CSF1R0.37925618
116CAMKK10.37337623
117MARK30.37296939
118PDGFRA0.37107413
119TNK20.36971130
120EPHA20.36823766
121CDK40.36423328
122SGK20.36030060
123CAMK1D0.34746737
124PDK10.34022365
125SRC0.33965012
126CSNK2A10.32346095
127RPS6KB10.32344638
128MAP3K90.31991654
129HIPK20.30853279
130MAPK120.29607238
131PRKCA0.29044125
132SGK2230.28502619
133SGK4940.28502619
134FER0.28442445
135PKN10.28092994
136PASK0.27924913
137MTOR0.26275505
138GRK10.26059973
139TGFBR20.24651427
140CSNK1G10.24621369
141PRKACA0.24135523
142EGFR0.21606574
143MAPK70.21540700

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.30709578
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.36933004
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.33781402
4Nitrogen metabolism_Homo sapiens_hsa009103.19271914
5Arginine biosynthesis_Homo sapiens_hsa002202.99614642
6Tryptophan metabolism_Homo sapiens_hsa003802.77806015
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.57281960
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.51007544
9Complement and coagulation cascades_Homo sapiens_hsa046102.49361767
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.48747161
11Fatty acid degradation_Homo sapiens_hsa000712.46771385
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.34680890
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32226139
14Butanoate metabolism_Homo sapiens_hsa006502.23026898
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11999481
16Peroxisome_Homo sapiens_hsa041462.09512021
17Histidine metabolism_Homo sapiens_hsa003402.05147736
18Maturity onset diabetes of the young_Homo sapiens_hsa049502.04130838
19Chemical carcinogenesis_Homo sapiens_hsa052041.89194289
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87639218
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.87329152
22Propanoate metabolism_Homo sapiens_hsa006401.84899061
23Sulfur metabolism_Homo sapiens_hsa009201.84812334
24PPAR signaling pathway_Homo sapiens_hsa033201.79926684
25Fatty acid metabolism_Homo sapiens_hsa012121.73269493
26Selenocompound metabolism_Homo sapiens_hsa004501.70866746
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.69714884
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67792195
29beta-Alanine metabolism_Homo sapiens_hsa004101.67070108
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63983841
31Caffeine metabolism_Homo sapiens_hsa002321.59738320
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59460988
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58375508
34Retinol metabolism_Homo sapiens_hsa008301.58298390
35Phenylalanine metabolism_Homo sapiens_hsa003601.58257198
36Bile secretion_Homo sapiens_hsa049761.55794372
37Tyrosine metabolism_Homo sapiens_hsa003501.55102854
38Staphylococcus aureus infection_Homo sapiens_hsa051501.50189621
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39452913
40Starch and sucrose metabolism_Homo sapiens_hsa005001.35321704
41Folate biosynthesis_Homo sapiens_hsa007901.34683044
42Pyruvate metabolism_Homo sapiens_hsa006201.34670885
43ABC transporters_Homo sapiens_hsa020101.26904890
44Fatty acid elongation_Homo sapiens_hsa000621.26687804
45Fat digestion and absorption_Homo sapiens_hsa049751.25475932
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.16932173
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.05834554
48Biosynthesis of amino acids_Homo sapiens_hsa012301.04848914
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03921596
50Steroid biosynthesis_Homo sapiens_hsa001000.99877006
51Carbon metabolism_Homo sapiens_hsa012000.99084630
52Vitamin digestion and absorption_Homo sapiens_hsa049770.98059639
53Arginine and proline metabolism_Homo sapiens_hsa003300.97073923
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93594336
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90335420
56Sulfur relay system_Homo sapiens_hsa041220.85229327
57Lysine degradation_Homo sapiens_hsa003100.79786485
58Vitamin B6 metabolism_Homo sapiens_hsa007500.77917460
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75981456
60Glycerolipid metabolism_Homo sapiens_hsa005610.66392488
61Glutathione metabolism_Homo sapiens_hsa004800.65274498
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63366367
63One carbon pool by folate_Homo sapiens_hsa006700.56398448
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51667293
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47591235
66Metabolic pathways_Homo sapiens_hsa011000.47084224
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46701716
68Pentose phosphate pathway_Homo sapiens_hsa000300.46627821
69Linoleic acid metabolism_Homo sapiens_hsa005910.43613524
70Prion diseases_Homo sapiens_hsa050200.42016534
71Fatty acid biosynthesis_Homo sapiens_hsa000610.37541458
72Galactose metabolism_Homo sapiens_hsa000520.35262626
73Fructose and mannose metabolism_Homo sapiens_hsa000510.28962124
74Insulin resistance_Homo sapiens_hsa049310.28889474
75Thyroid hormone synthesis_Homo sapiens_hsa049180.23330491
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.22816443
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.22460381
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.20118885
79Glucagon signaling pathway_Homo sapiens_hsa049220.18195011
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12576484
81Protein export_Homo sapiens_hsa030600.11262524
82Renin-angiotensin system_Homo sapiens_hsa046140.10644013
83Pertussis_Homo sapiens_hsa051330.09817393
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08624031
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.04054022
86Sphingolipid metabolism_Homo sapiens_hsa006000.03949390
87African trypanosomiasis_Homo sapiens_hsa05143-0.1915932
88Amoebiasis_Homo sapiens_hsa05146-0.1876033
89Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1845941
90Mineral absorption_Homo sapiens_hsa04978-0.1716803
91Bladder cancer_Homo sapiens_hsa05219-0.1703080
92Ether lipid metabolism_Homo sapiens_hsa00565-0.1671712
93Type II diabetes mellitus_Homo sapiens_hsa04930-0.1247932
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1182632
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1101120
96Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1078235
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0976427
98Insulin signaling pathway_Homo sapiens_hsa04910-0.0741385
99N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0685374
100Lysosome_Homo sapiens_hsa04142-0.0587240
101Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0509323
102Other glycan degradation_Homo sapiens_hsa00511-0.0399623
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0350903
104Serotonergic synapse_Homo sapiens_hsa04726-0.0311676
105Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0255020
106Autoimmune thyroid disease_Homo sapiens_hsa05320-0.0238844
107AMPK signaling pathway_Homo sapiens_hsa04152-0.0209172
108Regulation of autophagy_Homo sapiens_hsa04140-0.0203764

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