DIO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4) to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by outer ring 5'-deiodination. This gene is widely expressed, including in thyroid, placenta, pituitary and brain. It is thought to be responsible for the 'local' production of T3, and thus important in influencing thyroid hormone action in these tissues. It has also been reported to be highly expressed in thyroids of patients with Graves disease, and in follicular adenomas. The intrathyroidal T4 to T3 conversion by this enzyme may contribute significantly to the relative increase in thyroidal T3 production in these patients. This protein is a selenoprotein containing the rare selenocysteine (Sec) amino acid at its active site, and may contain additional Sec residues. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* thyroid hormone generation (GO:0006590)7.54418989
2* thyroid hormone metabolic process (GO:0042403)6.00924311
3L-amino acid import (GO:0043092)5.94098134
4cerebellar Purkinje cell layer development (GO:0021680)5.82364197
5barbed-end actin filament capping (GO:0051016)5.24344348
6nonmotile primary cilium assembly (GO:0035058)5.03560676
7oligodendrocyte differentiation (GO:0048709)5.02454658
8C4-dicarboxylate transport (GO:0015740)4.99821480
9amino acid import (GO:0043090)4.93217898
10long-chain fatty acid biosynthetic process (GO:0042759)4.92152466
11ectoderm development (GO:0007398)4.87012597
12locomotory exploration behavior (GO:0035641)4.86356572
13regulation of cell proliferation involved in kidney development (GO:1901722)4.68555261
14chaperone-mediated protein complex assembly (GO:0051131)4.65179858
15cell proliferation involved in kidney development (GO:0072111)4.63290476
16synaptic vesicle maturation (GO:0016188)4.35349567
17cellular potassium ion homeostasis (GO:0030007)4.33079340
18fatty acid elongation (GO:0030497)4.23531096
19sodium ion export (GO:0071436)4.21452529
20negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.17494281
21regulation of protein kinase C signaling (GO:0090036)3.97457867
22alanine transport (GO:0032328)3.93741507
23positive regulation of fatty acid beta-oxidation (GO:0032000)3.87586970
24synaptic vesicle docking involved in exocytosis (GO:0016081)3.79089378
25regulation of cardiac muscle cell contraction (GO:0086004)3.76207726
26mesenchymal-epithelial cell signaling (GO:0060638)3.68811133
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.68575400
28proline transport (GO:0015824)3.68014596
29glutamate secretion (GO:0014047)3.67324710
30ovulation cycle (GO:0042698)3.66725475
31regulation of short-term neuronal synaptic plasticity (GO:0048172)3.63850149
32positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.62358493
33dermatan sulfate biosynthetic process (GO:0030208)3.57412763
34regulation of glomerulus development (GO:0090192)3.57331346
35regulation of mesenchymal cell apoptotic process (GO:2001053)3.49550313
36dermatan sulfate metabolic process (GO:0030205)3.48702943
37branched-chain amino acid catabolic process (GO:0009083)3.48359627
38positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.47553840
39dicarboxylic acid biosynthetic process (GO:0043650)3.44825147
40chronic inflammatory response (GO:0002544)3.42819242
41presynaptic membrane assembly (GO:0097105)3.40074553
42synaptic vesicle exocytosis (GO:0016079)3.39529858
43dendrite morphogenesis (GO:0048813)3.38653687
44vocalization behavior (GO:0071625)3.37564698
45response to auditory stimulus (GO:0010996)3.36669120
46potassium ion import (GO:0010107)3.36164926
47chondroitin sulfate catabolic process (GO:0030207)3.32870640
48regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.32816333
49cell communication by electrical coupling (GO:0010644)3.32418347
50retinal metabolic process (GO:0042574)3.29785086
51regulation of alkaline phosphatase activity (GO:0010692)3.28838224
52pericardium development (GO:0060039)3.28749191
53neuromuscular synaptic transmission (GO:0007274)3.24073541
54layer formation in cerebral cortex (GO:0021819)3.23931688
55neurotransmitter catabolic process (GO:0042135)3.22499338
56cell proliferation involved in metanephros development (GO:0072203)3.22115777
57regulation of glutamate receptor signaling pathway (GO:1900449)3.19717305
58positive regulation of peptidyl-threonine phosphorylation (GO:0010800)3.19645577
59cell morphogenesis involved in neuron differentiation (GO:0048667)3.19023362
60branching involved in salivary gland morphogenesis (GO:0060445)3.18728441
61regulation of apoptotic process involved in morphogenesis (GO:1902337)3.18337637
62cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.16727454
63positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.14997937
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.12473337
65regulation of synapse structural plasticity (GO:0051823)3.11409214
66peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.09261405
67negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.08460600
68cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.08174326
69lateral sprouting from an epithelium (GO:0060601)3.07026588
70neurotransmitter-gated ion channel clustering (GO:0072578)3.05403998
71negative regulation of protein localization to cell surface (GO:2000009)3.04960808
72negative regulation of adenylate cyclase activity (GO:0007194)3.04456399
73positive regulation of fatty acid oxidation (GO:0046321)3.04279316
74gamma-aminobutyric acid transport (GO:0015812)3.03430162
75mesenchyme morphogenesis (GO:0072132)3.00844564
76mesonephros development (GO:0001823)3.00139883
77acidic amino acid transport (GO:0015800)2.98722834
78positive regulation of actin filament depolymerization (GO:0030836)2.98401877
79auditory behavior (GO:0031223)2.98009023
80exploration behavior (GO:0035640)2.97758454
81ionotropic glutamate receptor signaling pathway (GO:0035235)2.96926071
82regulation of long-term neuronal synaptic plasticity (GO:0048169)2.96007590
83keratinization (GO:0031424)2.94778349
84glutamate receptor signaling pathway (GO:0007215)2.94453711
85regulation of neuronal synaptic plasticity (GO:0048168)2.90210743
86regulation of neuron projection regeneration (GO:0070570)2.88810752
87regulation of axon regeneration (GO:0048679)2.88810752
88cellular sodium ion homeostasis (GO:0006883)2.88719144
89ganglion development (GO:0061548)2.87337428
90regulation of actin filament-based movement (GO:1903115)2.87096515
91regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.86508983
92cell adhesion mediated by integrin (GO:0033627)2.85881176
93negative regulation of cyclase activity (GO:0031280)2.85240443
94regulation of synaptic vesicle exocytosis (GO:2000300)2.84441719
95phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.84399698
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.83668696
97prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.82603055
98neuronal ion channel clustering (GO:0045161)2.81868889
99cellular response to cholesterol (GO:0071397)2.81625599
100cerebellar granule cell differentiation (GO:0021707)2.81273313
101peripheral nervous system axon ensheathment (GO:0032292)2.81187284
102myelination in peripheral nervous system (GO:0022011)2.81187284
103establishment of skin barrier (GO:0061436)2.80769633
104regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.80246039
105protein K11-linked deubiquitination (GO:0035871)2.78712015
106negative regulation of astrocyte differentiation (GO:0048712)2.78343332
107regulation of fatty acid beta-oxidation (GO:0031998)2.75628530
108synaptic transmission, glutamatergic (GO:0035249)2.75202788
109thyroid gland development (GO:0030878)2.73800928
110L-glutamate transport (GO:0015813)2.73758991
111positive regulation of glomerulus development (GO:0090193)2.72148663
112negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.71777286
113embryonic camera-type eye morphogenesis (GO:0048596)2.70893055
114desmosome organization (GO:0002934)2.70165866
115long-term memory (GO:0007616)2.68742924
116dendritic spine morphogenesis (GO:0060997)2.68685497
117neurotransmitter secretion (GO:0007269)2.68253550
118positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.67601402
119fibroblast migration (GO:0010761)2.67184098
120positive regulation of muscle hypertrophy (GO:0014742)2.66418397
121positive regulation of cardiac muscle hypertrophy (GO:0010613)2.66418397
122presynaptic membrane organization (GO:0097090)2.66234101
123regulation of water loss via skin (GO:0033561)2.65896106
124potassium ion homeostasis (GO:0055075)2.65804034
125positive regulation of mesenchymal cell proliferation (GO:0002053)2.65310298
126cellular response to gonadotropin stimulus (GO:0071371)2.64374685
127limb bud formation (GO:0060174)2.63705071
128protein localization to synapse (GO:0035418)2.62788190
129adrenergic receptor signaling pathway (GO:0071875)2.61206979
130positive regulation of cardiac muscle tissue growth (GO:0055023)2.60878509
131negative regulation of lyase activity (GO:0051350)2.59426912
132long-term synaptic potentiation (GO:0060291)2.59105150
133regulation of mesenchymal cell proliferation (GO:0010464)2.58934638
134* phenol-containing compound catabolic process (GO:0019336)2.58897140
135adenine nucleotide transport (GO:0051503)2.58486870
136inositol phosphate-mediated signaling (GO:0048016)2.58241396
137negative regulation of cAMP biosynthetic process (GO:0030818)2.56637972
138regulation of synaptic transmission, glutamatergic (GO:0051966)2.56074157
139glial cell proliferation (GO:0014009)2.55479410
140regulation of ARF protein signal transduction (GO:0032012)2.54461566
141regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.54301292
142branched-chain amino acid metabolic process (GO:0009081)2.54043260
143neuronal action potential propagation (GO:0019227)2.53834484
144negative regulation of systemic arterial blood pressure (GO:0003085)2.52540685
145glomerular basement membrane development (GO:0032836)2.52527426
146sulfate transmembrane transport (GO:1902358)2.52417664
147negative regulation of sodium ion transport (GO:0010766)2.49678719
148regulation of glial cell proliferation (GO:0060251)2.48744944
149negative regulation of osteoblast proliferation (GO:0033689)2.47760452
150craniofacial suture morphogenesis (GO:0097094)2.47550775
151neurotransmitter uptake (GO:0001504)2.47357824
152regulation of synaptic vesicle transport (GO:1902803)2.46853449
153neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.46630796
154regulation of excitatory postsynaptic membrane potential (GO:0060079)2.45631894
155positive regulation of cardiac muscle cell differentiation (GO:2000727)2.45499001
156negative regulation of nucleotide biosynthetic process (GO:0030809)2.45244052
157negative regulation of purine nucleotide biosynthetic process (GO:1900372)2.45244052
158negative regulation of catenin import into nucleus (GO:0035414)2.45106070
159regulation of synaptic plasticity (GO:0048167)2.44318686
160negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)2.43720331
161glial cell differentiation (GO:0010001)2.41881378
162postsynaptic membrane organization (GO:0001941)2.41191834
163negative regulation of smoothened signaling pathway (GO:0045879)2.41036239
164neuromuscular process controlling balance (GO:0050885)2.40867563
165central nervous system projection neuron axonogenesis (GO:0021952)2.40655360
166response to histamine (GO:0034776)2.37380690
167positive regulation of glucose import (GO:0046326)2.35497669
168mechanosensory behavior (GO:0007638)2.35200279
169prepulse inhibition (GO:0060134)2.35072134
170negative regulation of synaptic transmission, GABAergic (GO:0032229)2.33505082
171neuron-neuron synaptic transmission (GO:0007270)2.30700864
172cerebral cortex radially oriented cell migration (GO:0021799)2.29635856
173cellular response to sterol (GO:0036315)2.29378138
174visual behavior (GO:0007632)2.29362917
175positive regulation of synaptic transmission (GO:0050806)2.27383847
176neuron cell-cell adhesion (GO:0007158)2.27014557
177regulation of postsynaptic membrane potential (GO:0060078)2.24660952
178regulation of dendritic spine morphogenesis (GO:0061001)2.24330457
179regulation of beta-amyloid formation (GO:1902003)2.22935468
180chondroitin sulfate biosynthetic process (GO:0030206)2.22402229
181regulation of vesicle fusion (GO:0031338)2.21134848

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human5.59491594
2EZH2_22144423_ChIP-Seq_EOC_Human4.33884644
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.71975773
4GBX2_23144817_ChIP-Seq_PC3_Human2.66809039
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.62961817
6SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52377441
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.52238603
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.41411322
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41131864
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41131864
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37420334
12AR_21572438_ChIP-Seq_LNCaP_Human2.35521461
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34444146
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.31469703
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.29269305
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.25841854
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.21753972
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.20613669
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.19337455
20DROSHA_22980978_ChIP-Seq_HELA_Human2.11879025
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.09301664
22CJUN_26792858_Chip-Seq_BT549_Human2.05080817
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.04365289
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.03199707
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.02937939
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99420107
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97901962
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.92888889
29* ER_23166858_ChIP-Seq_MCF-7_Human1.87615719
30ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.76678903
31STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.64230074
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.64164919
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63831739
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.63691552
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62831213
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60684268
37* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.60576828
38* RXR_22108803_ChIP-Seq_LS180_Human1.57551181
39* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57390312
40SMAD4_21799915_ChIP-Seq_A2780_Human1.56081241
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.55581109
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55037009
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54279494
44TAF15_26573619_Chip-Seq_HEK293_Human1.53899419
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53087369
46EWS_26573619_Chip-Seq_HEK293_Human1.53004761
47TP53_16413492_ChIP-PET_HCT116_Human1.52637951
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52576906
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49908401
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.47746522
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44913000
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.41088932
53* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.40825272
54REST_21632747_ChIP-Seq_MESCs_Mouse1.40703452
55TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.39556124
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38396767
57SOX9_26525672_Chip-Seq_HEART_Mouse1.34976320
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34143542
59P300_19829295_ChIP-Seq_ESCs_Human1.33880448
60SMAD3_21741376_ChIP-Seq_HESCs_Human1.31863479
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31842678
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.31695956
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30212999
64BCAT_22108803_ChIP-Seq_LS180_Human1.29813910
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29095690
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.27805083
67* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27445093
68* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26160412
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.25763601
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.25374245
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25292158
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23526353
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23028279
74TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.22065058
75* AR_19668381_ChIP-Seq_PC3_Human1.21033297
76* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20449831
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20319219
78* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19747044
79* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19284017
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.19201690
81* TP53_18474530_ChIP-ChIP_U2OS_Human1.18652501
82STAT3_23295773_ChIP-Seq_U87_Human1.18197286
83* AR_25329375_ChIP-Seq_VCAP_Human1.16778830
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.16365461
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14918644
86AHR_22903824_ChIP-Seq_MCF-7_Human1.14549106
87NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13964136
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13964136
89CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13761994
90ISL1_27105846_Chip-Seq_CPCs_Mouse1.12514736
91* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11807135
92PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10966020
93CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10884439
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10579171
95EP300_21415370_ChIP-Seq_HL-1_Mouse1.10507022
96THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09800463
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08892826
98EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08868802
99BRD4_25478319_ChIP-Seq_HGPS_Human1.08766128
100TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06493316
101TCF4_23295773_ChIP-Seq_U87_Human1.06465631
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05071686
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03830985
104EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03589043
105TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03248676
106ESR2_21235772_ChIP-Seq_MCF-7_Human1.01989671
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01807945
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01531336
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01531336
110REST_18959480_ChIP-ChIP_MESCs_Mouse1.01068283
111TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01030204
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99104649
113NANOG_18555785_Chip-Seq_ESCs_Mouse0.98530427
114TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98444723
115TCF4_22108803_ChIP-Seq_LS180_Human0.98379074
116TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97210036
117AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97086361
118RING1B_27294783_Chip-Seq_NPCs_Mouse0.97077519
119NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96717387
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96145581
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95689187
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94069617
123TCF4_18268006_ChIP-ChIP_LS174T_Human0.93826244
124* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93780570
125* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92971226
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90626352
127CBX2_27304074_Chip-Seq_ESCs_Mouse0.90416932
128RUNX2_22187159_ChIP-Seq_PCA_Human0.90187501
129KDM2B_26808549_Chip-Seq_K562_Human0.90101798
130POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89817578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.98147658
2MP0000383_abnormal_hair_follicle3.61363588
3MP0009780_abnormal_chondrocyte_physiolo3.41370727
4MP0010678_abnormal_skin_adnexa2.91895687
5MP0004885_abnormal_endolymph2.84850222
6MP0003635_abnormal_synaptic_transmissio2.74932557
7MP0001299_abnormal_eye_distance/2.74538711
8MP0002254_reproductive_system_inflammat2.56388746
9MP0000681_abnormal_thyroid_gland2.44726552
10MP0001486_abnormal_startle_reflex2.42878481
11MP0004270_analgesia2.36678598
12MP0005503_abnormal_tendon_morphology2.36655339
13MP0004858_abnormal_nervous_system2.36264206
14MP0009046_muscle_twitch2.31053941
15MP0002063_abnormal_learning/memory/cond2.23402174
16MP0008438_abnormal_cutaneous_collagen2.23250038
17MP0002233_abnormal_nose_morphology2.11031598
18MP0002064_seizures2.07426582
19MP0002796_impaired_skin_barrier2.06396916
20MP0008569_lethality_at_weaning2.05581856
21MP0009745_abnormal_behavioral_response2.00951892
22MP0009384_cardiac_valve_regurgitation1.98178396
23MP0004134_abnormal_chest_morphology1.97323666
24MP0009250_abnormal_appendicular_skeleto1.93662554
25MP0002572_abnormal_emotion/affect_behav1.89258686
26MP0000566_synostosis1.84181516
27MP0003755_abnormal_palate_morphology1.82167855
28MP0003690_abnormal_glial_cell1.81423407
29MP0005646_abnormal_pituitary_gland1.81017256
30MP0002249_abnormal_larynx_morphology1.78075736
31MP0000751_myopathy1.73133399
32MP0005187_abnormal_penis_morphology1.69124832
33MP0001501_abnormal_sleep_pattern1.68810312
34MP0002876_abnormal_thyroid_physiology1.63622572
35MP0001502_abnormal_circadian_rhythm1.62895963
36MP0002098_abnormal_vibrissa_morphology1.53837623
37MP0001177_atelectasis1.52885420
38MP0008789_abnormal_olfactory_epithelium1.51850193
39MP0002734_abnormal_mechanical_nocicepti1.51829344
40MP0004043_abnormal_pH_regulation1.51266860
41MP0002234_abnormal_pharynx_morphology1.49001543
42MP0002272_abnormal_nervous_system1.48260771
43MP0010771_integument_phenotype1.47343574
44MP0003942_abnormal_urinary_system1.46999924
45MP0001958_emphysema1.46138191
46MP0005248_abnormal_Harderian_gland1.41265489
47MP0001440_abnormal_grooming_behavior1.40778629
48MP0003937_abnormal_limbs/digits/tail_de1.40544981
49MP0000427_abnormal_hair_cycle1.39070144
50MP0001666_abnormal_nutrient_absorption1.38167747
51MP0001984_abnormal_olfaction1.38151163
52MP0001968_abnormal_touch/_nociception1.37223769
53MP0002557_abnormal_social/conspecific_i1.37190256
54MP0002089_abnormal_postnatal_growth/wei1.36443959
55MP0003183_abnormal_peptide_metabolism1.36174926
56MP0003656_abnormal_erythrocyte_physiolo1.33640227
57MP0000778_abnormal_nervous_system1.31255649
58MP0003633_abnormal_nervous_system1.30718414
59MP0010234_abnormal_vibrissa_follicle1.29548636
60MP0005083_abnormal_biliary_tract1.28989098
61MP0003935_abnormal_craniofacial_develop1.28244723
62MP0003880_abnormal_central_pattern1.27648036
63MP0004130_abnormal_muscle_cell1.25248936
64MP0005377_hearing/vestibular/ear_phenot1.23618462
65MP0003878_abnormal_ear_physiology1.23618462
66MP0000569_abnormal_digit_pigmentation1.22758646
67MP0006054_spinal_hemorrhage1.22547021
68MP0001485_abnormal_pinna_reflex1.21857515
69MP0002108_abnormal_muscle_morphology1.17043229
70MP0002009_preneoplasia1.16304027
71MP0002067_abnormal_sensory_capabilities1.15397115
72MP0000377_abnormal_hair_follicle1.14449597
73MP0005645_abnormal_hypothalamus_physiol1.13774776
74MP0000762_abnormal_tongue_morphology1.12935159
75MP0003329_amyloid_beta_deposits1.10799896
76MP0005595_abnormal_vascular_smooth1.10220722
77MP0000428_abnormal_craniofacial_morphol1.09443439
78MP0000534_abnormal_ureter_morphology1.09410598
79MP0005394_taste/olfaction_phenotype1.08515739
80MP0005499_abnormal_olfactory_system1.08515739
81MP0000163_abnormal_cartilage_morphology1.08227669
82MP0003631_nervous_system_phenotype1.07417697
83MP0002733_abnormal_thermal_nociception1.06842538
84MP0005275_abnormal_skin_tensile1.04930342
85MP0002115_abnormal_skeleton_extremities1.03652767
86MP0005386_behavior/neurological_phenoty1.02955674
87MP0004924_abnormal_behavior1.02955674
88MP0002882_abnormal_neuron_morphology1.02250941
89MP0005171_absent_coat_pigmentation1.01559935
90MP0001970_abnormal_pain_threshold1.01381974
91MP0005423_abnormal_somatic_nervous1.00983648
92MP0003634_abnormal_glial_cell1.00898806
93MP0000955_abnormal_spinal_cord1.00697654
94MP0004883_abnormal_blood_vessel1.00124398
95MP0005409_darkened_coat_color0.99287275
96MP0002735_abnormal_chemical_nociception0.97268729
97MP0003075_altered_response_to0.96846052
98MP0002127_abnormal_cardiovascular_syste0.96823656
99MP0000920_abnormal_myelination0.96445788
100MP0002090_abnormal_vision0.96235410
101MP0000003_abnormal_adipose_tissue0.95385149
102MP0002971_abnormal_brown_adipose0.94434657
103MP0002736_abnormal_nociception_after0.94060173
104MP0002938_white_spotting0.93820766
105MP0000538_abnormal_urinary_bladder0.92059042
106MP0006072_abnormal_retinal_apoptosis0.91654791
107MP0004811_abnormal_neuron_physiology0.91465149
108MP0003136_yellow_coat_color0.90987017
109MP0003705_abnormal_hypodermis_morpholog0.90954457
110MP0009053_abnormal_anal_canal0.90656832
111MP0002822_catalepsy0.90396059
112MP0002060_abnormal_skin_morphology0.90321936
113MP0003279_aneurysm0.90137552
114MP0000462_abnormal_digestive_system0.89321230
115MP0000432_abnormal_head_morphology0.89060491
116MP0002909_abnormal_adrenal_gland0.89026124
117MP0010030_abnormal_orbit_morphology0.88444958
118MP0003632_abnormal_nervous_system0.88242681
119MP0002282_abnormal_trachea_morphology0.88092552
120MP0004215_abnormal_myocardial_fiber0.87772023
121MP0004272_abnormal_basement_membrane0.87499159
122MP0005508_abnormal_skeleton_morphology0.85728759
123MP0001346_abnormal_lacrimal_gland0.85547193
124MP0002896_abnormal_bone_mineralization0.84353180
125MP0000049_abnormal_middle_ear0.81897269
126MP0002116_abnormal_craniofacial_bone0.81328931
127MP0008775_abnormal_heart_ventricle0.80623244
128MP0002066_abnormal_motor_capabilities/c0.80450531
129MP0000647_abnormal_sebaceous_gland0.80384460
130MP0003045_fibrosis0.80127830
131MP0001764_abnormal_homeostasis0.78967271
132MP0005164_abnormal_response_to0.78782877
133MP0005257_abnormal_intraocular_pressure0.78462836
134MP0002152_abnormal_brain_morphology0.78056256
135MP0002168_other_aberrant_phenotype0.77168086
136MP0005501_abnormal_skin_physiology0.76730991
137MP0002638_abnormal_pupillary_reflex0.76509292
138MP0005023_abnormal_wound_healing0.76300145
139MP0003300_gastrointestinal_ulcer0.75068923
140MP0000579_abnormal_nail_morphology0.74616275
141MP0001963_abnormal_hearing_physiology0.73805095
142MP0002109_abnormal_limb_morphology0.72690061
143MP0008961_abnormal_basal_metabolism0.72688188
144MP0002092_abnormal_eye_morphology0.72487029
145MP0008872_abnormal_physiological_respon0.72092881
146MP0000631_abnormal_neuroendocrine_gland0.70882941
147MP0000026_abnormal_inner_ear0.70856297
148MP0009931_abnormal_skin_appearance0.70231480
149MP0002697_abnormal_eye_size0.69166907
150MP0003186_abnormal_redox_activity0.68808186
151MP0004019_abnormal_vitamin_homeostasis0.68453388
152MP0002932_abnormal_joint_morphology0.68120274
153MP0003453_abnormal_keratinocyte_physiol0.67962863
154MP0001542_abnormal_bone_strength0.66378156
155MP0005551_abnormal_eye_electrophysiolog0.65729210

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the upper limbs (HP:0009823)5.80530953
2Aplasia of the phalanges of the hand (HP:0009802)5.80530953
3Aplasia involving bones of the extremities (HP:0009825)5.80530953
4Spastic paraparesis (HP:0002313)3.96660235
5Goiter (HP:0000853)3.85370808
6Megalencephaly (HP:0001355)3.78844991
7Focal motor seizures (HP:0011153)3.68012484
8Abnormality of the labia majora (HP:0012881)3.64050233
9Popliteal pterygium (HP:0009756)3.47524089
10Sensorimotor neuropathy (HP:0007141)3.40556707
11Broad metatarsal (HP:0001783)3.36192110
12Gait imbalance (HP:0002141)3.33181598
13Metaphyseal dysplasia (HP:0100255)3.31533925
14Aplasia of the musculature (HP:0100854)3.28630414
15Congenital primary aphakia (HP:0007707)3.24986113
16Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.19355009
17Intestinal atresia (HP:0011100)3.12264403
18Action tremor (HP:0002345)3.09100921
19Abnormality of calcium-phosphate metabolism (HP:0100530)3.06106599
20Hypoplastic labia majora (HP:0000059)3.02639257
21Increased density of long bones (HP:0006392)2.97039918
22Abnormality of the parietal bone (HP:0002696)2.91931943
23Spondylolisthesis (HP:0003302)2.89708558
24Shallow orbits (HP:0000586)2.89676504
25Trigonocephaly (HP:0000243)2.86570384
26Hypoplastic ischia (HP:0003175)2.82396167
27Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)2.82237387
28Myokymia (HP:0002411)2.81222170
29Abnormality of the middle phalanges of the toes (HP:0010183)2.79989544
30Thyroid carcinoma (HP:0002890)2.78806001
31Nephrogenic diabetes insipidus (HP:0009806)2.76697882
32Epileptic encephalopathy (HP:0200134)2.71387573
33Arterial tortuosity (HP:0005116)2.67353810
34Short 4th metacarpal (HP:0010044)2.65624576
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.65624576
36Abnormality of the proximal phalanges of the hand (HP:0009834)2.65259018
37Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.64869364
38Midline defect of the nose (HP:0004122)2.64471780
39Vaginal atresia (HP:0000148)2.58084204
40Medial flaring of the eyebrow (HP:0010747)2.56236197
41Focal seizures (HP:0007359)2.55551469
42Genital tract atresia (HP:0001827)2.53855847
43Symphalangism affecting the phalanges of the hand (HP:0009773)2.51869811
44Vascular tortuosity (HP:0004948)2.51661955
45Cystic hygroma (HP:0000476)2.50440808
46Aplasia/Hypoplasia of the lens (HP:0008063)2.50360588
47Short hallux (HP:0010109)2.50352509
48Abnormality of the ischium (HP:0003174)2.49673532
49Poor coordination (HP:0002370)2.46759118
50Bifid tongue (HP:0010297)2.46156463
51Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.45758569
52Abnormality of secondary sexual hair (HP:0009888)2.42943372
53Abnormality of the axillary hair (HP:0100134)2.42943372
54Epiphyseal dysplasia (HP:0002656)2.41952872
55Laryngomalacia (HP:0001601)2.40944466
56Cutaneous melanoma (HP:0012056)2.40001775
57Increased number of teeth (HP:0011069)2.38889139
58Progressive cerebellar ataxia (HP:0002073)2.38489148
59Polycythemia (HP:0001901)2.37239029
60Vitreoretinal degeneration (HP:0000655)2.35681069
61Neonatal respiratory distress (HP:0002643)2.35634431
62Bronchomalacia (HP:0002780)2.35256826
63Overgrowth (HP:0001548)2.34675636
64Mixed hearing impairment (HP:0000410)2.33364183
65Mild short stature (HP:0003502)2.32664916
66Thyroid-stimulating hormone excess (HP:0002925)2.32380016
67Erythroderma (HP:0001019)2.32111930
68Aplasia/Hypoplasia of the hallux (HP:0008362)2.31910791
69Abnormality of incisor morphology (HP:0011063)2.31315730
70Choroideremia (HP:0001139)2.28975401
71Genetic anticipation (HP:0003743)2.28395769
72Abnormality of the middle phalanges of the hand (HP:0009833)2.28169138
73Narrow palate (HP:0000189)2.26865721
74Neoplasm of the heart (HP:0100544)2.24529144
75Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.22561878
76Split foot (HP:0001839)2.21906680
77Pili torti (HP:0003777)2.21817348
78Abnormality of the phalanges of the 2nd finger (HP:0009541)2.19872530
79Abnormality of nail color (HP:0100643)2.19485477
80Alacrima (HP:0000522)2.16512436
81Abnormality of the frontal sinuses (HP:0002687)2.15361249
82Curly hair (HP:0002212)2.15242063
83Abnormality of the diencephalon (HP:0010662)2.14996527
84Exostoses (HP:0100777)2.14742383
85Macroorchidism (HP:0000053)2.12995149
86Fibular aplasia (HP:0002990)2.12437805
87Small epiphyses (HP:0010585)2.11839431
88Bell-shaped thorax (HP:0001591)2.11042370
89Dysdiadochokinesis (HP:0002075)2.10091190
90Synostosis involving the elbow (HP:0003938)2.10011470
91Humeroradial synostosis (HP:0003041)2.10011470
92Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.09831474
93Infantile muscular hypotonia (HP:0008947)2.09746498
94Nasolacrimal duct obstruction (HP:0000579)2.08635876
95Microglossia (HP:0000171)2.06794850
96Sparse lateral eyebrow (HP:0005338)2.05432467
97Depressed nasal tip (HP:0000437)2.05340398
98Neonatal short-limb short stature (HP:0008921)2.04675764
99Abnormality of the nasal septum (HP:0000419)2.04009279
100Dental crowding (HP:0000678)2.03829112
101Congenital ichthyosiform erythroderma (HP:0007431)2.03154531
102Left ventricular hypertrophy (HP:0001712)2.02892955
103Flat capital femoral epiphysis (HP:0003370)2.02789246
104Abnormality of the distal phalanx of the thumb (HP:0009617)2.02750258
105Paraparesis (HP:0002385)2.02610255
106Congenital sensorineural hearing impairment (HP:0008527)2.01827438
107Coronal craniosynostosis (HP:0004440)2.01563120
108Hemiplegia (HP:0002301)1.98374895
109Aortic dissection (HP:0002647)1.98160428
110Asymmetry of the thorax (HP:0001555)1.97253895
111Broad face (HP:0000283)1.96868281
112Abnormality of placental membranes (HP:0011409)1.96122216
113Amniotic constriction ring (HP:0009775)1.96122216
114Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.95536528
115Abnormal eating behavior (HP:0100738)1.95096821
116Meningioma (HP:0002858)1.94165745
117Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.93359954
118Broad hallux (HP:0010055)1.93168934
119Tibial bowing (HP:0002982)1.92632561
120Ulnar bowing (HP:0003031)1.92229605
121Knee flexion contracture (HP:0006380)1.91690301
122Heterotopia (HP:0002282)1.91529908
123Difficulty running (HP:0009046)1.90214585
124Anteriorly placed anus (HP:0001545)1.89726432
125Abnormality of the labia (HP:0000058)1.89266148
126Absent frontal sinuses (HP:0002688)1.88393351
127Hemiparesis (HP:0001269)1.88111495
128Akinesia (HP:0002304)1.88078116
129Conical tooth (HP:0000698)1.87185063
130Adactyly (HP:0009776)1.86995161
131Synostosis involving bones of the feet (HP:0009140)1.86588401
132Synostosis involving bones of the lower limbs (HP:0009138)1.86588401
133Papilledema (HP:0001085)1.85522123
134Clumsiness (HP:0002312)1.85496949
135Onycholysis (HP:0001806)1.85262120
136Preaxial foot polydactyly (HP:0001841)1.84362631
137Termporal pattern (HP:0011008)1.83877890
138Insidious onset (HP:0003587)1.83877890
139Cubitus valgus (HP:0002967)1.83130295
140Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.82925212
141Labial hypoplasia (HP:0000066)1.82652059
142Abnormality of binocular vision (HP:0011514)1.82600398
143Diplopia (HP:0000651)1.82600398
144Thickened helices (HP:0000391)1.82365944
145Turricephaly (HP:0000262)1.81956436
146Hypomagnesemia (HP:0002917)1.81546567
147Soft skin (HP:0000977)1.78621786
148Long toe (HP:0010511)1.78102077
149Aqueductal stenosis (HP:0002410)1.77929561
150Pterygium (HP:0001059)1.77888735
151Ulnar claw (HP:0001178)1.77528210
152Aortic aneurysm (HP:0004942)1.77461436
153Cupped ribs (HP:0000887)1.76128925
154Hypopigmentation of the fundus (HP:0007894)1.75877025
155Postural instability (HP:0002172)1.75622485
156Toxemia of pregnancy (HP:0100603)1.72969221
157Decreased lacrimation (HP:0000633)1.72258988
158Febrile seizures (HP:0002373)1.71067175
159Generalized tonic-clonic seizures (HP:0002069)1.71000369
160Long nose (HP:0003189)1.70752361
161Protrusio acetabuli (HP:0003179)1.70674827
162Hyperventilation (HP:0002883)1.70085242
163Thin ribs (HP:0000883)1.69865637
164Abnormality of the epiphyses of the hand (HP:0005924)1.69594742
165Broad toe (HP:0001837)1.66877733
1662-3 toe syndactyly (HP:0004691)1.66869710
167Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.66850828
168Concave nail (HP:0001598)1.65921415
169Abnormality of the 4th metacarpal (HP:0010012)1.63976489
170Broad long bones (HP:0005622)1.63641225
171Follicular hyperkeratosis (HP:0007502)1.63059264
172Short middle phalanx of finger (HP:0005819)1.62955019
173Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.61648651
174Accelerated skeletal maturation (HP:0005616)1.61313255
175Large earlobe (HP:0009748)1.59986435
176Short metatarsal (HP:0010743)1.59084224
177Cervical subluxation (HP:0003308)1.57915378
178Obstructive sleep apnea (HP:0002870)1.57119345
179Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.56785121
180Premature skin wrinkling (HP:0100678)1.56476600
181Premature rupture of membranes (HP:0001788)1.54277140

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.71094851
2TRIB33.29376977
3TNIK3.09984845
4AKT33.05475323
5MUSK2.77838941
6PRKD32.74618447
7NTRK22.73466004
8NTRK32.70628824
9RPS6KB22.66049162
10RPS6KA42.56618111
11DDR22.50633587
12FGFR22.47308062
13RIPK12.29851752
14PNCK2.18935214
15SGK32.17512969
16SGK22.15384831
17CAMK2G2.14154307
18LATS12.13384723
19RAF12.11856228
20DYRK31.94314881
21SIK11.83441060
22MAP3K91.78606290
23CAMKK11.65735537
24MAP2K11.65491584
25MAPKAPK31.64710058
26LMTK21.62648367
27MAP3K41.60380776
28NTRK11.58774530
29DMPK1.57071033
30SGK4941.56861010
31SGK2231.56861010
32MAP3K61.53860888
33CAMK1G1.52894597
34BRD41.52032549
35PHKG11.43065352
36PHKG21.43065352
37DAPK21.41602907
38PAK61.38742610
39MAP2K21.33442839
40CAMK1D1.30420927
41MINK11.29537228
42CAMK2B1.28174091
43PDK21.27003632
44MET1.26532860
45KSR21.25785740
46MAP2K71.23633734
47MST1R1.20094913
48PLK21.19346956
49PDGFRA1.15660710
50CDK51.14966853
51MAP3K131.13968303
52CASK1.13156586
53PRPF4B1.09805350
54CAMKK21.07591121
55KSR11.05681029
56RPS6KA21.03793509
57INSRR1.00531463
58JAK11.00514129
59FGFR30.99678777
60BMX0.97013870
61PIK3CA0.94671057
62MARK10.94497272
63RET0.94025154
64PRKCH0.93641460
65TTN0.93135839
66PRKCZ0.91265992
67CAMK2D0.91190191
68TAOK10.90316322
69FGFR10.89625480
70ICK0.89181880
71STK380.89072543
72STK390.84211034
73MAPK130.83621791
74CAMK10.83559211
75TYRO30.83041407
76ERBB40.81999017
77PINK10.80412623
78SGK10.79792121
79NUAK10.78156478
80MYLK0.77735266
81PAK30.77703622
82MAP2K40.77022497
83PDPK10.76936311
84SIK20.74891448
85PDGFRB0.73954810
86PRKCG0.73302354
87CSNK1A1L0.72485410
88CAMK40.70937059
89RIPK40.70772289
90MAP3K20.70318311
91PKN10.69837802
92PDK10.69531246
93MAP3K70.67548942
94MATK0.64977559
95WEE10.64471358
96STK110.64337311
97FES0.63733009
98ERBB20.62122304
99PRKCE0.62059228
100MARK20.61490086
101STK38L0.61162721
102RPS6KA10.59922588
103EPHA20.59631198
104TAOK30.58814436
105CSNK1A10.58160674
106TGFBR10.57565006
107ILK0.56443211
108SRPK10.56177522
109EPHA30.53420746
110STK240.52825670
111MAPK70.52066092
112ROCK10.49882972
113DYRK1A0.49698715
114MAP3K120.48713251
115RPS6KL10.48126327
116RPS6KC10.48126327
117RPS6KA30.47834752
118BMPR1B0.47328071
119CSNK1G10.46214191
120PRKCQ0.45720332
121PRKACG0.45308232
122ADRBK10.45169576
123RPS6KA60.44918594
124LATS20.44237855
125FRK0.44097399
126TNK20.44042863
127CAMK2A0.43841110
128PRKD10.42641270
129PRKAA20.41989099
130CDK150.41768200
131YES10.40829340
132ALK0.40342595
133CDK180.39659404
134CDK30.39653641
135STK30.39652240
136GSK3A0.39084803
137PTK2B0.38446177
138MAPK120.38400448
139PRKD20.38338679
140CDK140.38287639
141DAPK10.37415125
142NEK60.37283939
143FER0.37194977
144MAPK100.35508388
145ROCK20.35183857
146PBK0.35145291
147AKT20.34815518
148GRK50.33317798
149PRKG10.33027086
150FYN0.32805970
151HIPK20.32709231
152RPS6KB10.32642689
153ACVR1B0.30730320

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009106.85794214
2Propanoate metabolism_Homo sapiens_hsa006402.46271887
3Fatty acid biosynthesis_Homo sapiens_hsa000612.13053761
4Glutamatergic synapse_Homo sapiens_hsa047242.01945877
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.01537299
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95708041
7Olfactory transduction_Homo sapiens_hsa047401.91789884
8Nicotine addiction_Homo sapiens_hsa050331.85196800
9Circadian entrainment_Homo sapiens_hsa047131.81818790
10GABAergic synapse_Homo sapiens_hsa047271.73689311
11TGF-beta signaling pathway_Homo sapiens_hsa043501.69434083
12Long-term potentiation_Homo sapiens_hsa047201.69137015
13Morphine addiction_Homo sapiens_hsa050321.63751451
14Gastric acid secretion_Homo sapiens_hsa049711.62690375
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.61147474
16Salivary secretion_Homo sapiens_hsa049701.60230693
17Histidine metabolism_Homo sapiens_hsa003401.52323895
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51734053
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44692237
20Amphetamine addiction_Homo sapiens_hsa050311.41902105
21Cholinergic synapse_Homo sapiens_hsa047251.40904888
22Insulin secretion_Homo sapiens_hsa049111.40179248
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34945639
24Synaptic vesicle cycle_Homo sapiens_hsa047211.34252361
25Glioma_Homo sapiens_hsa052141.29811068
26Circadian rhythm_Homo sapiens_hsa047101.29549902
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26864466
28cAMP signaling pathway_Homo sapiens_hsa040241.24164959
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23587422
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18992589
31Calcium signaling pathway_Homo sapiens_hsa040201.18772298
32Dorso-ventral axis formation_Homo sapiens_hsa043201.17707267
33Dopaminergic synapse_Homo sapiens_hsa047281.16892785
34Renin secretion_Homo sapiens_hsa049241.16030223
35Cocaine addiction_Homo sapiens_hsa050301.09477963
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08373426
37Oxytocin signaling pathway_Homo sapiens_hsa049211.06671283
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04628950
39Long-term depression_Homo sapiens_hsa047301.04325029
40GnRH signaling pathway_Homo sapiens_hsa049121.04033915
41Phospholipase D signaling pathway_Homo sapiens_hsa040721.03974304
42Melanoma_Homo sapiens_hsa052180.94383503
43* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94359221
44Dilated cardiomyopathy_Homo sapiens_hsa054140.92260662
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90529725
46Gap junction_Homo sapiens_hsa045400.90431041
47Basal cell carcinoma_Homo sapiens_hsa052170.90411976
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90333588
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90245911
50Estrogen signaling pathway_Homo sapiens_hsa049150.89713322
51Lysine degradation_Homo sapiens_hsa003100.88296089
52ErbB signaling pathway_Homo sapiens_hsa040120.88064028
53Melanogenesis_Homo sapiens_hsa049160.87800575
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85975783
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83707702
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82585944
57Rap1 signaling pathway_Homo sapiens_hsa040150.81638542
58ECM-receptor interaction_Homo sapiens_hsa045120.81188523
59Thyroid hormone synthesis_Homo sapiens_hsa049180.81007840
60Proteoglycans in cancer_Homo sapiens_hsa052050.80785637
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80588288
62Type II diabetes mellitus_Homo sapiens_hsa049300.77776597
63Serotonergic synapse_Homo sapiens_hsa047260.77086124
64Prolactin signaling pathway_Homo sapiens_hsa049170.76736532
65Wnt signaling pathway_Homo sapiens_hsa043100.76479616
66Choline metabolism in cancer_Homo sapiens_hsa052310.75786333
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.75454330
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.75421639
69Focal adhesion_Homo sapiens_hsa045100.74922805
70Hedgehog signaling pathway_Homo sapiens_hsa043400.73677347
71Phenylalanine metabolism_Homo sapiens_hsa003600.72998382
72Ras signaling pathway_Homo sapiens_hsa040140.72474786
73MAPK signaling pathway_Homo sapiens_hsa040100.71414622
74Chronic myeloid leukemia_Homo sapiens_hsa052200.69873458
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69842892
76Glucagon signaling pathway_Homo sapiens_hsa049220.69769659
77Adherens junction_Homo sapiens_hsa045200.69375341
78beta-Alanine metabolism_Homo sapiens_hsa004100.69366613
79Fatty acid metabolism_Homo sapiens_hsa012120.69168636
80Amoebiasis_Homo sapiens_hsa051460.68339820
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67039842
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66868760
83Endometrial cancer_Homo sapiens_hsa052130.65693412
84Hippo signaling pathway_Homo sapiens_hsa043900.64239117
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64114252
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63827389
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62560569
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62044835
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60890634
90FoxO signaling pathway_Homo sapiens_hsa040680.60720601
91Pancreatic secretion_Homo sapiens_hsa049720.60178920
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.59823397
93Small cell lung cancer_Homo sapiens_hsa052220.59712225
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59425398
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.58436702
96ABC transporters_Homo sapiens_hsa020100.58379350
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56884761
98Taste transduction_Homo sapiens_hsa047420.56736890
99Bile secretion_Homo sapiens_hsa049760.56386241
100Axon guidance_Homo sapiens_hsa043600.56294833
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56215212
102Non-small cell lung cancer_Homo sapiens_hsa052230.55984087
103Renal cell carcinoma_Homo sapiens_hsa052110.55253858
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.53718196
105AMPK signaling pathway_Homo sapiens_hsa041520.53705158
106Tyrosine metabolism_Homo sapiens_hsa003500.53390589
107Tryptophan metabolism_Homo sapiens_hsa003800.51884013
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51708944
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51607064
110TNF signaling pathway_Homo sapiens_hsa046680.51481713
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50476725
112Colorectal cancer_Homo sapiens_hsa052100.50430841
113VEGF signaling pathway_Homo sapiens_hsa043700.50317950
114Protein digestion and absorption_Homo sapiens_hsa049740.49950566
115mTOR signaling pathway_Homo sapiens_hsa041500.49040254
116Hepatitis C_Homo sapiens_hsa051600.48367150
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48290022
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48204109
119Insulin resistance_Homo sapiens_hsa049310.48151070
120Insulin signaling pathway_Homo sapiens_hsa049100.47281553
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45752031
122African trypanosomiasis_Homo sapiens_hsa051430.45213568
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44019188
124Pancreatic cancer_Homo sapiens_hsa052120.42312771
125Arginine biosynthesis_Homo sapiens_hsa002200.40200460
126Prostate cancer_Homo sapiens_hsa052150.40196810
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39690172

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