DIP2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the disco-interacting protein homolog 2 protein family. The encoded protein contains a binding site for the transcriptional regulator DNA methyltransferase 1 associated protein 1 as well as AMP-binding sites. The presence of these sites suggests that the encoded protein may participate in DNA methylation. This gene is located near a folate-sensitive fragile site, and CGG-repeat expansion in the promoter of this gene which affects transcription has been detected in individuals containing this fragile site on chromosome 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.40406171
2central nervous system myelination (GO:0022010)6.40406171
3negative regulation of neurotransmitter secretion (GO:0046929)4.58477672
4long-chain fatty acid biosynthetic process (GO:0042759)4.37953955
5myelination (GO:0042552)4.36231162
6presynaptic membrane assembly (GO:0097105)4.35582917
7ensheathment of neurons (GO:0007272)4.32864823
8axon ensheathment (GO:0008366)4.32864823
9presynaptic membrane organization (GO:0097090)4.18640984
10negative regulation of neurotransmitter transport (GO:0051589)4.16156145
11regulation of ARF protein signal transduction (GO:0032012)3.90906797
12cytoskeletal anchoring at plasma membrane (GO:0007016)3.83680541
13fatty acid elongation (GO:0030497)3.77885100
14L-amino acid import (GO:0043092)3.74014272
15regulation of collateral sprouting (GO:0048670)3.58974511
16regulation of NFAT protein import into nucleus (GO:0051532)3.47994615
17histone H3-K36 demethylation (GO:0070544)3.42853410
18neuron cell-cell adhesion (GO:0007158)3.39077915
19negative regulation of protein localization to cell surface (GO:2000009)3.20640079
20myelination in peripheral nervous system (GO:0022011)3.16569660
21peripheral nervous system axon ensheathment (GO:0032292)3.16569660
22nuclear pore complex assembly (GO:0051292)3.16361502
23negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.13022701
24cerebral cortex radially oriented cell migration (GO:0021799)3.12674667
25cerebellar granule cell differentiation (GO:0021707)3.11324385
26hemidesmosome assembly (GO:0031581)3.09061757
27layer formation in cerebral cortex (GO:0021819)3.07786818
28photoreceptor cell differentiation (GO:0046530)3.04828726
29eye photoreceptor cell differentiation (GO:0001754)3.04828726
30oligodendrocyte differentiation (GO:0048709)3.02275870
31sodium ion export (GO:0071436)3.00188623
32peptidyl-threonine phosphorylation (GO:0018107)2.98841737
33peptidyl-threonine modification (GO:0018210)2.96276658
34positive regulation of action potential (GO:0045760)2.96273295
35embryonic retina morphogenesis in camera-type eye (GO:0060059)2.94838373
36Rap protein signal transduction (GO:0032486)2.94437492
37cyclic nucleotide catabolic process (GO:0009214)2.90496822
38nerve growth factor signaling pathway (GO:0038180)2.90205174
39regulation of nucleobase-containing compound transport (GO:0032239)2.88570996
40myelin maintenance (GO:0043217)2.87683471
41negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.87050522
42positive regulation of cellular amide metabolic process (GO:0034250)2.86894949
43cytoplasmic mRNA processing body assembly (GO:0033962)2.86187910
44neuronal action potential propagation (GO:0019227)2.84201782
45desmosome organization (GO:0002934)2.81848462
46developmental pigmentation (GO:0048066)2.80827647
47regulation of RNA export from nucleus (GO:0046831)2.79430525
48detection of molecule of bacterial origin (GO:0032490)2.79128173
49histone H3-K9 demethylation (GO:0033169)2.76617784
50amino acid import (GO:0043090)2.73624383
51epithelial cell differentiation involved in prostate gland development (GO:0060742)2.72963462
52negative regulation of synaptic transmission, GABAergic (GO:0032229)2.72880187
53cellular response to epinephrine stimulus (GO:0071872)2.72776973
54negative regulation of axonogenesis (GO:0050771)2.72647609
55apical protein localization (GO:0045176)2.71639751
56asymmetric protein localization (GO:0008105)2.71419949
57histone lysine demethylation (GO:0070076)2.70387085
58negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.69622769
59cellular response to ethanol (GO:0071361)2.67568075
60limb bud formation (GO:0060174)2.67079594
61regulation of beta-amyloid formation (GO:1902003)2.66580487
62establishment of nucleus localization (GO:0040023)2.66334496
63membrane assembly (GO:0071709)2.64789724
64synaptic vesicle docking involved in exocytosis (GO:0016081)2.62230310
65adult walking behavior (GO:0007628)2.58913521
66protein localization to endosome (GO:0036010)2.58878931
67cellular response to catecholamine stimulus (GO:0071870)2.58339623
68cellular response to monoamine stimulus (GO:0071868)2.58339623
69astrocyte development (GO:0014002)2.58047921
70histone demethylation (GO:0016577)2.57716445
71response to redox state (GO:0051775)2.57233170
72clathrin coat assembly (GO:0048268)2.57181110
73negative regulation of axon extension (GO:0030517)2.54749597
74embryonic camera-type eye morphogenesis (GO:0048596)2.54176101
75mechanosensory behavior (GO:0007638)2.53940156
76cortical actin cytoskeleton organization (GO:0030866)2.53884954
77membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.53199347
78glycerophospholipid catabolic process (GO:0046475)2.53095457
79regulation of histone H3-K27 methylation (GO:0061085)2.52596614
80regulation of Rac protein signal transduction (GO:0035020)2.51283449
81positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.50729227
82synaptic vesicle exocytosis (GO:0016079)2.49364403
83positive regulation of Rap GTPase activity (GO:0032854)2.49020536
84nuclear pore organization (GO:0006999)2.48422115
85transmission of nerve impulse (GO:0019226)2.48046369
86positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.48026295
87dicarboxylic acid biosynthetic process (GO:0043650)2.47209966
88regulation of Rap GTPase activity (GO:0032317)2.47181639
89regulation of clathrin-mediated endocytosis (GO:2000369)2.46967749
90insulin-like growth factor receptor signaling pathway (GO:0048009)2.46510292
91cellular potassium ion homeostasis (GO:0030007)2.46494593
92establishment of mitochondrion localization (GO:0051654)2.45839566
93pore complex assembly (GO:0046931)2.45487385
94iron ion import (GO:0097286)2.44569886
95startle response (GO:0001964)2.41507003
96postsynaptic membrane organization (GO:0001941)2.40727644
97substantia nigra development (GO:0021762)2.40098703
98regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.39838557
99negative regulation of dendrite morphogenesis (GO:0050774)2.39235091
100ER overload response (GO:0006983)2.38230148
101response to catecholamine (GO:0071869)2.37724128
102response to monoamine (GO:0071867)2.37724128
103ionotropic glutamate receptor signaling pathway (GO:0035235)2.37245384
104regulation of synaptic vesicle exocytosis (GO:2000300)2.36847479
105gamma-aminobutyric acid signaling pathway (GO:0007214)2.36685328
106Rac protein signal transduction (GO:0016601)2.36515821
107peripheral nervous system development (GO:0007422)2.36103953
108morphogenesis of an epithelial sheet (GO:0002011)2.35342158
109regulation of interleukin-13 production (GO:0032656)2.35338155
110cerebellar Purkinje cell differentiation (GO:0021702)2.34735263
111regulation of pigment cell differentiation (GO:0050932)2.34167639
112response to epinephrine (GO:0071871)2.33727402
113cAMP catabolic process (GO:0006198)2.33597242
114phospholipid translocation (GO:0045332)2.33507305
115lipid translocation (GO:0034204)2.33507305
116regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.33504908
117regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.31544986
118vesicle docking involved in exocytosis (GO:0006904)2.31498310
119regulation of voltage-gated calcium channel activity (GO:1901385)2.31369412
120Golgi to endosome transport (GO:0006895)2.31367673
121long-term synaptic potentiation (GO:0060291)2.30982215
122positive regulation of oligodendrocyte differentiation (GO:0048714)2.30972530
123positive regulation of Rac GTPase activity (GO:0032855)2.30170396
124dendrite development (GO:0016358)2.29984475
125locomotory exploration behavior (GO:0035641)2.29920731
126macroautophagy (GO:0016236)2.28473093
127neuron recognition (GO:0008038)2.28422052
128activated T cell proliferation (GO:0050798)2.28153847
129axonal fasciculation (GO:0007413)2.27264828
130regulation of cellular amide metabolic process (GO:0034248)2.26991997
131cortical cytoskeleton organization (GO:0030865)2.26848825
132G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.26650734
133peptidyl-tyrosine autophosphorylation (GO:0038083)2.26632301
134response to lipoprotein particle (GO:0055094)2.25887814
135neuron-neuron synaptic transmission (GO:0007270)2.25257759
136Golgi to plasma membrane protein transport (GO:0043001)2.24733432
137neurotransmitter uptake (GO:0001504)2.24518502
138phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.24470682
139synaptic transmission, glutamatergic (GO:0035249)2.23300655
140hypotonic response (GO:0006971)2.22557124
141negative regulation of exocytosis (GO:0045920)2.22314755
142cell-substrate junction assembly (GO:0007044)2.21064288
143embryonic process involved in female pregnancy (GO:0060136)2.20064193
144dendritic spine morphogenesis (GO:0060997)2.19454979
145negative regulation of axon extension involved in axon guidance (GO:0048843)2.19390751
146import into cell (GO:0098657)2.18232368
147glutamate receptor signaling pathway (GO:0007215)2.17531359
148vesicle transport along microtubule (GO:0047496)2.17472043
149regulation of synaptic transmission, GABAergic (GO:0032228)2.17378827
150glutamate secretion (GO:0014047)2.17112355
151protein demethylation (GO:0006482)2.16280115
152protein dealkylation (GO:0008214)2.16280115
153activation of Rac GTPase activity (GO:0032863)2.15583381
154stress granule assembly (GO:0034063)2.15264158
155negative regulation of synaptic transmission (GO:0050805)2.14786281
156regulation of ARF GTPase activity (GO:0032312)2.14137900
157protein localization to synapse (GO:0035418)2.14135313
158synaptic vesicle maturation (GO:0016188)2.14133757
159auditory behavior (GO:0031223)2.13799578
160neuronal ion channel clustering (GO:0045161)2.13217143
161protein neddylation (GO:0045116)2.12774605
162positive regulation of macroautophagy (GO:0016239)2.12486499
163macrophage activation involved in immune response (GO:0002281)2.11843529
164magnesium ion transport (GO:0015693)2.11456964
165negative regulation of axon guidance (GO:1902668)2.11225956
166positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.10946525
167protein targeting to lysosome (GO:0006622)2.10322236
168establishment of protein localization to vacuole (GO:0072666)2.10322236
169protein targeting to vacuole (GO:0006623)2.10322236
170glucocorticoid receptor signaling pathway (GO:0042921)2.09037569
171coronary vasculature morphogenesis (GO:0060977)2.08976170
172corticosteroid receptor signaling pathway (GO:0031958)2.08760553
173regulation of water loss via skin (GO:0033561)2.08127111
174positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.07629635
175peptidyl-serine phosphorylation (GO:0018105)2.06955122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.90962066
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.66281636
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.58784769
4EZH2_22144423_ChIP-Seq_EOC_Human2.96508057
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.80049979
6* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.37418442
7TAF15_26573619_Chip-Seq_HEK293_Human2.30278274
8VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.27875421
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25728184
10SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.22028670
11TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.12277375
12AR_21572438_ChIP-Seq_LNCaP_Human2.10399831
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.07569300
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03906550
15GATA1_22025678_ChIP-Seq_K562_Human2.02508649
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.02420119
17POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99755379
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.98977054
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.97580325
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.96510530
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96385740
22OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.95133082
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.93211830
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88427528
25P300_19829295_ChIP-Seq_ESCs_Human1.85670129
26* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85102792
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.82379310
28DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.82154413
29ER_23166858_ChIP-Seq_MCF-7_Human1.76277193
30* FOXA2_19822575_ChIP-Seq_HepG2_Human1.72549931
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.72351292
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71107633
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.69423556
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.69084910
35SMAD3_21741376_ChIP-Seq_EPCs_Human1.67380296
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.66470444
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65649468
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.65609685
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65453773
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.65123631
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64159552
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64100799
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.63655538
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.62000294
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59510757
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59376238
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59311591
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59311591
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.58246992
50* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56205048
51DROSHA_22980978_ChIP-Seq_HELA_Human1.55851311
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.55590165
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.53741089
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53354562
55TCF7_22412390_ChIP-Seq_EML_Mouse1.52378685
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51249990
57AHR_22903824_ChIP-Seq_MCF-7_Human1.50574492
58FUS_26573619_Chip-Seq_HEK293_Human1.49903717
59STAT3_23295773_ChIP-Seq_U87_Human1.49840838
60* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48750310
61KDM2B_26808549_Chip-Seq_K562_Human1.48566835
62SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.48173053
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47290868
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46885951
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.46139605
66SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46116488
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.45294836
68* ARNT_22903824_ChIP-Seq_MCF-7_Human1.45285014
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.45136477
70* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45121206
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44050241
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43129946
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42511397
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41388931
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41281389
76NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40342836
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.40034805
78JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39209824
79VDR_22108803_ChIP-Seq_LS180_Human1.38399778
80TCF4_23295773_ChIP-Seq_U87_Human1.36071835
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36066950
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33150661
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.33102386
84EWS_26573619_Chip-Seq_HEK293_Human1.33049313
85* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32200270
86* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31519932
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31247950
88SALL1_21062744_ChIP-ChIP_HESCs_Human1.30949440
89* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30636568
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.29659954
91SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29576594
92EZH2_27294783_Chip-Seq_ESCs_Mouse1.29082423
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27656984
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27656984
95TCF4_18268006_ChIP-ChIP_LS174T_Human1.27330096
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27117109
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26031283
98RNF2_27304074_Chip-Seq_NSC_Mouse1.25994574
99* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25854519
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.25164107
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25146447
102KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24621791
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24489792
104TP53_16413492_ChIP-PET_HCT116_Human1.24478882
105E2F1_18555785_Chip-Seq_ESCs_Mouse1.24087125
106REST_21632747_ChIP-Seq_MESCs_Mouse1.22819653
107SCL_19346495_ChIP-Seq_HPC-7_Human1.22085502
108P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21861426
109NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20815412
110CLOCK_20551151_ChIP-Seq_293T_Human1.20474164
111EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20198869
112NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18611878
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18611878
114PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18591706
115SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18392994
116SOX2_21211035_ChIP-Seq_LN229_Gbm1.17364911
117P53_22387025_ChIP-Seq_ESCs_Mouse1.16769297
118TP53_18474530_ChIP-ChIP_U2OS_Human1.16559364
119SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15958542
120SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15958542
121FLI1_27457419_Chip-Seq_LIVER_Mouse1.15900902
122* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15502941
123GATA2_21666600_ChIP-Seq_HMVEC_Human1.14903846
124RARB_27405468_Chip-Seq_BRAIN_Mouse1.14301321
125LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14094521
126* RUNX2_22187159_ChIP-Seq_PCA_Human1.13235447
127* EP300_21415370_ChIP-Seq_HL-1_Mouse1.13118206
128IGF1R_20145208_ChIP-Seq_DFB_Human1.13024525
129* AR_25329375_ChIP-Seq_VCAP_Human1.13022266
130KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13004593
131IRF8_27001747_Chip-Seq_BMDM_Mouse1.12632051
132BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12436916
133* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12389886
134HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11745227
135P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11149050
136TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10722868
137* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09718025
138SOX9_26525672_Chip-Seq_HEART_Mouse1.09280481
139ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09000387
140KDM2B_26808549_Chip-Seq_JURKAT_Human1.08761796
141P300_18555785_Chip-Seq_ESCs_Mouse1.07769019
142SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07319351
143KDM2B_26808549_Chip-Seq_DND41_Human1.07269985
144STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07215984
145ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06700129
146* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06433141
147UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06262553
148YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04226066
149SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01511532
150SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99122733
151SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98724154
152NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98578289
153SPI1_23127762_ChIP-Seq_K562_Human0.98506164
154* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97383798
155GATA1_19941827_ChIP-Seq_MEL_Mouse0.95549175
156AR_19668381_ChIP-Seq_PC3_Human0.95434135
157KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95163000
158* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94977822
159GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94925135
160PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94708551
161FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94273683
162ISL1_27105846_Chip-Seq_CPCs_Mouse0.93616628
163TP63_23658742_ChIP-Seq_EP156T_Human0.92619032
164* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92528694
165PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92125000
166RUNX1_27514584_Chip-Seq_MCF-7_Human0.90999589
167SMAD3_21741376_ChIP-Seq_HESCs_Human0.90973919
168GATA2_19941826_ChIP-Seq_K562_Human0.90937710
169PU_27001747_Chip-Seq_BMDM_Mouse0.89686695
170ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89192044
171RUNX_20019798_ChIP-Seq_JUKART_Human0.89061811

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.02444523
2MP0003880_abnormal_central_pattern3.94262372
3MP0005171_absent_coat_pigmentation3.59925724
4MP0000920_abnormal_myelination3.49907890
5MP0004270_analgesia2.81862337
6MP0005409_darkened_coat_color2.71216687
7MP0008057_abnormal_DNA_replication2.50832403
8MP0003950_abnormal_plasma_membrane2.49964554
9MP0000569_abnormal_digit_pigmentation2.42380103
10MP0009046_muscle_twitch2.41826961
11MP0004742_abnormal_vestibular_system2.39939975
12MP0001486_abnormal_startle_reflex2.36515887
13MP0008260_abnormal_autophagy2.35545585
14MP0004859_abnormal_synaptic_plasticity2.34376495
15MP0000579_abnormal_nail_morphology2.33477550
16MP0000778_abnormal_nervous_system2.31222491
17MP0002064_seizures2.30127392
18MP0003787_abnormal_imprinting2.25534128
19MP0002272_abnormal_nervous_system2.22953445
20MP0010352_gastrointestinal_tract_polyps2.22427293
21MP0003690_abnormal_glial_cell2.19639177
22MP0005248_abnormal_Harderian_gland2.18964148
23MP0001188_hyperpigmentation2.16804709
24MP0003300_gastrointestinal_ulcer2.15267509
25MP0002877_abnormal_melanocyte_morpholog2.09093374
26MP0003635_abnormal_synaptic_transmissio2.07113963
27MP0005423_abnormal_somatic_nervous2.05066653
28MP0003329_amyloid_beta_deposits2.01846751
29MP0003172_abnormal_lysosome_physiology1.99610596
30MP0005076_abnormal_cell_differentiation1.98663222
31MP0003303_peritoneal_inflammation1.98173120
32MP0001529_abnormal_vocalization1.95670360
33MP0009745_abnormal_behavioral_response1.90853152
34MP0003705_abnormal_hypodermis_morpholog1.88181852
35MP0003453_abnormal_keratinocyte_physiol1.86423442
36MP0002734_abnormal_mechanical_nocicepti1.78939200
37MP0001968_abnormal_touch/_nociception1.78103949
38MP0003091_abnormal_cell_migration1.77909919
39MP0003566_abnormal_cell_adhesion1.77250318
40MP0002063_abnormal_learning/memory/cond1.72901622
41MP0003634_abnormal_glial_cell1.72549232
42MP0002572_abnormal_emotion/affect_behav1.71458728
43MP0004264_abnormal_extraembryonic_tissu1.70345648
44MP0002735_abnormal_chemical_nociception1.67576884
45MP0001905_abnormal_dopamine_level1.67314760
46MP0003136_yellow_coat_color1.63748510
47MP0002796_impaired_skin_barrier1.62907372
48MP0000015_abnormal_ear_pigmentation1.60324773
49MP0004142_abnormal_muscle_tone1.59251320
50MP0001346_abnormal_lacrimal_gland1.57873389
51MP0000566_synostosis1.57254955
52MP0001915_intracranial_hemorrhage1.56271428
53MP0002067_abnormal_sensory_capabilities1.55299028
54MP0001485_abnormal_pinna_reflex1.51741878
55MP0004885_abnormal_endolymph1.51527587
56MP0002736_abnormal_nociception_after1.50395738
57MP0003191_abnormal_cellular_cholesterol1.49981104
58MP0002396_abnormal_hematopoietic_system1.45833638
59MP0003632_abnormal_nervous_system1.45555725
60MP0000383_abnormal_hair_follicle1.45489853
61MP0008569_lethality_at_weaning1.44364232
62MP0003183_abnormal_peptide_metabolism1.43948513
63MP0005645_abnormal_hypothalamus_physiol1.42310236
64MP0002166_altered_tumor_susceptibility1.40353617
65MP0002163_abnormal_gland_morphology1.39334607
66MP0000372_irregular_coat_pigmentation1.36677243
67MP0000377_abnormal_hair_follicle1.35470947
68MP0009780_abnormal_chondrocyte_physiolo1.32634609
69MP0002882_abnormal_neuron_morphology1.30591810
70MP0000955_abnormal_spinal_cord1.29364891
71MP0005310_abnormal_salivary_gland1.27584736
72MP0001299_abnormal_eye_distance/1.27326089
73MP0002229_neurodegeneration1.25143457
74MP0010678_abnormal_skin_adnexa1.24704646
75MP0004134_abnormal_chest_morphology1.23942915
76MP0002909_abnormal_adrenal_gland1.23942538
77MP0005386_behavior/neurological_phenoty1.23699242
78MP0004924_abnormal_behavior1.23699242
79MP0005646_abnormal_pituitary_gland1.22859408
80MP0001970_abnormal_pain_threshold1.20583565
81MP0003631_nervous_system_phenotype1.20506300
82MP0004381_abnormal_hair_follicle1.19681820
83MP0002184_abnormal_innervation1.17939164
84MP0000371_diluted_coat_color1.17580547
85MP0001849_ear_inflammation1.15122842
86MP0004808_abnormal_hematopoietic_stem1.14488588
87MP0001216_abnormal_epidermal_layer1.09787125
88MP0003868_abnormal_feces_composition1.09426781
89MP0003122_maternal_imprinting1.09060205
90MP0001963_abnormal_hearing_physiology1.09028609
91MP0002098_abnormal_vibrissa_morphology1.08906615
92MP0005621_abnormal_cell_physiology1.08552885
93MP0001440_abnormal_grooming_behavior1.08466855
94MP0004185_abnormal_adipocyte_glucose1.06660683
95MP0003633_abnormal_nervous_system1.03110236
96MP0001984_abnormal_olfaction1.03080547
97MP0002066_abnormal_motor_capabilities/c1.02382487
98MP0005623_abnormal_meninges_morphology1.01295387
99MP0003045_fibrosis1.00243308
100MP0004947_skin_inflammation0.99637087
101MP0002733_abnormal_thermal_nociception0.99128923
102MP0003123_paternal_imprinting0.98938853
103MP0000604_amyloidosis0.98353797
104MP0002557_abnormal_social/conspecific_i0.97783661
105MP0001986_abnormal_taste_sensitivity0.97388458
106MP0002006_tumorigenesis0.96754428
107MP0001177_atelectasis0.96188315
108MP0005551_abnormal_eye_electrophysiolog0.95673558
109MP0001851_eye_inflammation0.94523427
110MP0003121_genomic_imprinting0.93522273
111MP0004811_abnormal_neuron_physiology0.90844569
112MP0005058_abnormal_lysosome_morphology0.90562934
113MP0002752_abnormal_somatic_nervous0.89570187
114MP0002095_abnormal_skin_pigmentation0.89405227
115MP0002152_abnormal_brain_morphology0.88738877
116MP0002938_white_spotting0.88050448
117MP0005671_abnormal_response_to0.85140712
118MP0004147_increased_porphyrin_level0.83895219
119MP0000427_abnormal_hair_cycle0.83228820
120MP0003656_abnormal_erythrocyte_physiolo0.81380223
121MP0008877_abnormal_DNA_methylation0.79446182
122MP0001502_abnormal_circadian_rhythm0.78696878
123MP0001348_abnormal_lacrimal_gland0.78474937
124MP0003221_abnormal_cardiomyocyte_apopto0.78459827
125MP0002089_abnormal_postnatal_growth/wei0.77677202
126MP0003828_pulmonary_edema0.77492542
127MP0002060_abnormal_skin_morphology0.77454482
128MP0000631_abnormal_neuroendocrine_gland0.76468920
129MP0005666_abnormal_adipose_tissue0.76355838
130MP0004510_myositis0.75813530
131MP0000026_abnormal_inner_ear0.75461578
132MP0003385_abnormal_body_wall0.74803211
133MP0003943_abnormal_hepatobiliary_system0.73649942
134MP0003115_abnormal_respiratory_system0.73138186
135MP0005410_abnormal_fertilization0.72557056
136MP0005174_abnormal_tail_pigmentation0.72043205
137MP0002086_abnormal_extraembryonic_tissu0.72042483
138MP0000647_abnormal_sebaceous_gland0.71517622
139MP0002075_abnormal_coat/hair_pigmentati0.69577547
140MP0005379_endocrine/exocrine_gland_phen0.69445920
141MP0003937_abnormal_limbs/digits/tail_de0.69398839
142MP0005384_cellular_phenotype0.68945398
143MP0001186_pigmentation_phenotype0.67665111
144MP0005408_hypopigmentation0.66183565
145MP0005501_abnormal_skin_physiology0.65977295
146MP0000537_abnormal_urethra_morphology0.64794771
147MP0002148_abnormal_hypersensitivity_rea0.64612027
148MP0009115_abnormal_fat_cell0.63108466
149MP0005195_abnormal_posterior_eye0.62667348
150MP0002009_preneoplasia0.60750630
151MP0000627_abnormal_mammary_gland0.60358870
152MP0005451_abnormal_body_composition0.60352880
153MP0002971_abnormal_brown_adipose0.59585152
154MP0003861_abnormal_nervous_system0.58956753
155MP0004883_abnormal_blood_vessel0.58923871
156MP0000367_abnormal_coat/_hair0.58846067
157MP0001790_abnormal_immune_system0.58521444
158MP0005387_immune_system_phenotype0.58521444
159MP0003938_abnormal_ear_development0.57515937
160MP0009250_abnormal_appendicular_skeleto0.57337312
161MP0009672_abnormal_birth_weight0.55924063

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.12614704
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.12614704
3Sensory axonal neuropathy (HP:0003390)4.01126727
4Abnormality of the corticospinal tract (HP:0002492)3.88499336
5Focal motor seizures (HP:0011153)3.71896171
6Epileptic encephalopathy (HP:0200134)3.39345402
7Atonic seizures (HP:0010819)3.33578144
8Abnormal hair whorl (HP:0010721)3.31344931
9Subacute progressive viral hepatitis (HP:0006572)3.23046469
10Parakeratosis (HP:0001036)3.09635749
11Abnormality of incisor morphology (HP:0011063)2.91105690
12Peripheral hypomyelination (HP:0007182)2.83668307
13White forelock (HP:0002211)2.76905332
14Dysmetric saccades (HP:0000641)2.75728038
15Insidious onset (HP:0003587)2.74385948
16Termporal pattern (HP:0011008)2.74385948
17Germ cell neoplasia (HP:0100728)2.71704682
18Blue irides (HP:0000635)2.70914213
19Neurofibrillary tangles (HP:0002185)2.65851963
20Onion bulb formation (HP:0003383)2.65339281
21Abnormality of nail color (HP:0100643)2.63337661
22Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.61170689
23Spastic gait (HP:0002064)2.55308129
24Heterotopia (HP:0002282)2.55122123
25Macroorchidism (HP:0000053)2.54754523
26Vertebral arch anomaly (HP:0008438)2.52281841
27Ankyloglossia (HP:0010296)2.47776506
28Patchy hypopigmentation of hair (HP:0011365)2.43120363
29Abnormal auditory evoked potentials (HP:0006958)2.37027403
30Akinesia (HP:0002304)2.36783615
31Progressive cerebellar ataxia (HP:0002073)2.35876188
32Gaze-evoked nystagmus (HP:0000640)2.35793417
33Urinary bladder sphincter dysfunction (HP:0002839)2.35637212
34Broad-based gait (HP:0002136)2.35082643
35Febrile seizures (HP:0002373)2.32604215
36Focal seizures (HP:0007359)2.32112877
37Alacrima (HP:0000522)2.29744986
38Scanning speech (HP:0002168)2.26942528
39Dysmetria (HP:0001310)2.24569765
40Absent speech (HP:0001344)2.23264344
41Vaginal atresia (HP:0000148)2.22876022
42Genital tract atresia (HP:0001827)2.22484602
43Decreased motor nerve conduction velocity (HP:0003431)2.22373941
44Cerebral hypomyelination (HP:0006808)2.21607297
45Ankle clonus (HP:0011448)2.19740594
46Abnormality of the nasal septum (HP:0000419)2.17753721
47Asymmetry of the thorax (HP:0001555)2.15137077
48Medial flaring of the eyebrow (HP:0010747)2.13632719
49Anteriorly placed anus (HP:0001545)2.13258860
50Decreased lacrimation (HP:0000633)2.12595035
51Segmental peripheral demyelination/remyelination (HP:0003481)2.10823112
52Testicular neoplasm (HP:0010788)2.10814218
53Supranuclear gaze palsy (HP:0000605)2.09546483
54Curly hair (HP:0002212)2.08664001
55Lower limb muscle weakness (HP:0007340)2.08579512
56Hypoplasia of the iris (HP:0007676)2.07673271
57Aqueductal stenosis (HP:0002410)2.06950220
58Thickened helices (HP:0000391)2.06689573
59Hyperventilation (HP:0002883)2.06265713
60Slow saccadic eye movements (HP:0000514)2.06195400
61Transitional cell carcinoma of the bladder (HP:0006740)2.06173993
62Flat acetabular roof (HP:0003180)2.05898304
63Milia (HP:0001056)2.05056975
64Action tremor (HP:0002345)2.04657761
65Autoamputation (HP:0001218)2.04239572
66Fetal akinesia sequence (HP:0001989)2.04004517
67Gait imbalance (HP:0002141)2.02926212
68Split foot (HP:0001839)2.02048158
69Widely spaced teeth (HP:0000687)2.01135150
70Deep philtrum (HP:0002002)2.00190092
71Congenital sensorineural hearing impairment (HP:0008527)1.99241693
72Relative macrocephaly (HP:0004482)1.97269003
73Thyroid carcinoma (HP:0002890)1.96580825
74Esophageal atresia (HP:0002032)1.96194751
75Bladder carcinoma (HP:0002862)1.94570368
76Bladder neoplasm (HP:0009725)1.94570368
77Absent septum pellucidum (HP:0001331)1.94494930
78Absent/shortened dynein arms (HP:0200106)1.93828821
79Dynein arm defect of respiratory motile cilia (HP:0012255)1.93828821
80Clumsiness (HP:0002312)1.92921197
81Heterochromia iridis (HP:0001100)1.92462371
82Drooling (HP:0002307)1.91486386
83Excessive salivation (HP:0003781)1.91486386
84Thick nail (HP:0001805)1.91193304
85Myokymia (HP:0002411)1.90541777
86Viral hepatitis (HP:0006562)1.90281490
87Intention tremor (HP:0002080)1.89287875
88Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.88521334
89Right ventricular cardiomyopathy (HP:0011663)1.88357864
90Congenital primary aphakia (HP:0007707)1.87959532
91Micronodular cirrhosis (HP:0001413)1.87537632
92Eczematoid dermatitis (HP:0000976)1.86451405
93Cupped ear (HP:0000378)1.86115697
94Leiomyosarcoma (HP:0100243)1.85627733
95Uterine leiomyosarcoma (HP:0002891)1.85627733
96Nephrogenic diabetes insipidus (HP:0009806)1.85241048
97Pheochromocytoma (HP:0002666)1.84931591
98Septo-optic dysplasia (HP:0100842)1.84797504
99Bowel incontinence (HP:0002607)1.84447188
100Abnormality of the fingertips (HP:0001211)1.84264651
101Urinary urgency (HP:0000012)1.83946917
102Truncal ataxia (HP:0002078)1.83339628
103Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81802998
104Poor speech (HP:0002465)1.81154707
105Gastrointestinal atresia (HP:0002589)1.80637528
106Difficulty running (HP:0009046)1.80423906
107Gastroesophageal reflux (HP:0002020)1.79957833
108Cubitus valgus (HP:0002967)1.78924674
109Premature skin wrinkling (HP:0100678)1.78844382
110Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.78290335
111Abnormality of oral frenula (HP:0000190)1.77159161
112Coarse hair (HP:0002208)1.76771803
113Hypoplastic pelvis (HP:0008839)1.76278734
114Abnormal large intestine physiology (HP:0012700)1.75504529
115Poor coordination (HP:0002370)1.74704658
116Myelomeningocele (HP:0002475)1.73427960
117Plantar hyperkeratosis (HP:0007556)1.72177288
118Hammertoe (HP:0001765)1.71551064
119Neuronal loss in central nervous system (HP:0002529)1.70424659
120Hepatoblastoma (HP:0002884)1.70381214
121Hypopigmentation of the fundus (HP:0007894)1.68204569
122Abnormality of binocular vision (HP:0011514)1.68124380
123Diplopia (HP:0000651)1.68124380
124Abnormality of the septum pellucidum (HP:0007375)1.68013554
125Neuroendocrine neoplasm (HP:0100634)1.67991250
126Dialeptic seizures (HP:0011146)1.67515870
127Septate vagina (HP:0001153)1.67130382
128Specific learning disability (HP:0001328)1.66692974
129Papillary thyroid carcinoma (HP:0002895)1.66657396
130Stomach cancer (HP:0012126)1.66226982
131Abnormality of the salivary glands (HP:0010286)1.66168557
132Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.65667347
133Low anterior hairline (HP:0000294)1.65465056
134Cerebral inclusion bodies (HP:0100314)1.65262734
135Open mouth (HP:0000194)1.64602563
136Impaired vibratory sensation (HP:0002495)1.63516557
137Conical tooth (HP:0000698)1.63365907
138Obstructive sleep apnea (HP:0002870)1.63110872
139Abnormality of salivation (HP:0100755)1.62953395
140Menstrual irregularities (HP:0000858)1.62933313
141Overgrowth (HP:0001548)1.62431164
142Choroideremia (HP:0001139)1.62340992
143Recurrent bacterial skin infections (HP:0005406)1.61659134
144Deep venous thrombosis (HP:0002625)1.61343951
145Postural instability (HP:0002172)1.59733893
146Tapered finger (HP:0001182)1.59573406
147Midline defect of the nose (HP:0004122)1.59480370
148Aplasia involving bones of the upper limbs (HP:0009823)1.59231888
149Aplasia of the phalanges of the hand (HP:0009802)1.59231888
150Aplasia involving bones of the extremities (HP:0009825)1.59231888
151Steppage gait (HP:0003376)1.57595882
152Apathy (HP:0000741)1.55286227
153Arterial tortuosity (HP:0005116)1.55093516
154Renal cell carcinoma (HP:0005584)1.55002256
155Megalencephaly (HP:0001355)1.54915327
156Generalized hypopigmentation of hair (HP:0011358)1.53701674
157Gingivitis (HP:0000230)1.52562615
158Palmoplantar hyperkeratosis (HP:0000972)1.51232634
159Abnormality of the distal phalanx of the thumb (HP:0009617)1.50347239
160Palmar hyperkeratosis (HP:0010765)1.49388120
161Spastic paraplegia (HP:0001258)1.49146945
162Truncal obesity (HP:0001956)1.49074281
163Sandal gap (HP:0001852)1.48799438
164Hypoplasia of dental enamel (HP:0006297)1.48379529
165Gastrointestinal carcinoma (HP:0002672)1.48219268
166Malignant gastrointestinal tract tumors (HP:0006749)1.48219268
167Impaired vibration sensation in the lower limbs (HP:0002166)1.47250372
168Distal sensory impairment (HP:0002936)1.47114553
169Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.46359944

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.69592287
2STK393.64098245
3CDK123.35294669
4OXSR13.13389588
5BCR3.05764372
6PRPF4B2.75815016
7PKN12.73329847
8EPHB12.56451982
9TNIK2.50541224
10FGFR32.27577129
11MAPK132.27373946
12KSR22.23313060
13MAP3K22.15439025
14FGFR42.07446749
15RIPK12.02827579
16SGK4942.01854637
17SGK2232.01854637
18TRIB32.00148911
19SIK31.96109946
20MAP3K91.84015972
21MST41.79563797
22FGFR21.78886045
23NEK61.78375807
24CDK191.66084859
25WNK11.62894631
26EEF2K1.57779818
27MAPKAPK51.57584669
28PDGFRA1.56310769
29KSR11.54668807
30CLK11.53485265
31CAMK1D1.52019982
32SGK21.51248578
33MAP3K141.49937201
34RET1.44488763
35BMPR21.42763241
36SCYL21.36377837
37AKT31.33750111
38MAP2K71.32851034
39TAOK11.30530912
40UHMK11.30489703
41BMPR1B1.29648238
42PLK21.27657820
43PKN21.24717665
44MET1.23869065
45MAP3K11.21929195
46CSNK1A1L1.19264510
47EPHA41.15744500
48ROCK21.14903523
49SIK21.14516292
50TXK1.11988984
51LATS21.05428924
52NTRK21.04404492
53PBK1.04285584
54RAF11.03795237
55CSNK1G31.03084905
56FER1.01732455
57NTRK31.01435224
58RIPK40.99745156
59TRPM70.96289733
60SGK30.96148964
61CAMKK10.95830811
62WNK40.94476024
63JAK20.94461909
64YES10.94087788
65CDK60.93525650
66CSNK1G20.93521367
67CAMK2B0.92165359
68CDK30.90969794
69MAP3K40.89681814
70MTOR0.88960515
71PRKCQ0.86032353
72PRKCE0.85730198
73BLK0.85501687
74MAP3K130.85187577
75PAK60.84819362
76LATS10.84166788
77MAP3K100.83693228
78EPHA30.83505136
79STK380.82190312
80CSNK1G10.81108678
81MARK10.80094913
82SIK10.80020347
83ERBB20.78596570
84DMPK0.77693814
85FGR0.77478065
86CAMK2A0.76642335
87CDK50.76462213
88PTK60.75261731
89SGK10.72400144
90MAP3K60.72312905
91GRK70.71281996
92IRAK40.70774339
93MAPK70.69848744
94PAK30.68778585
95SMG10.68591302
96RPS6KB10.68444266
97IRAK10.68230541
98CAMK2D0.67688271
99MARK20.66722048
100PRKCH0.64789084
101CAMKK20.63761821
102DYRK1A0.61615460
103MAP2K40.59528195
104IRAK20.57694184
105ADRBK20.56838964
106FGFR10.55111600
107CSK0.52813424
108TYK20.51153890
109HCK0.49946396
110PRKG10.49893232
111FES0.49776592
112CAMK1G0.49152590
113ALK0.48282872
114IKBKB0.48204466
115DYRK20.46007318
116PRKD10.45538508
117MINK10.45164133
118CHUK0.44574412
119ROCK10.44227523
120CAMK40.44203679
121PTK20.43486544
122STK110.42874202
123FYN0.42583701
124JAK10.41977354
125DAPK20.41811539
126ERBB40.41314845
127RPS6KB20.41169922
128PDGFRB0.39804718
129ICK0.39523242
130CDK180.38591454
131MAP3K70.37916443
132CSNK1A10.37070032
133NTRK10.36918726
134LIMK10.36772112
135PRKD30.36268532
136CSNK1D0.35311996
137CDK140.35201964
138MKNK10.34717327
139PRKCZ0.33903751
140CSF1R0.33216682
141INSRR0.33021180
142MAPK100.32463494
143PDPK10.32336227
144PDK10.31436915
145ITK0.30848641
146RPS6KA20.30758651
147NLK0.30129613
148CDK150.30030121
149BRD40.29075474
150TYRO30.28921330
151NUAK10.28733730

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.50238815
2Axon guidance_Homo sapiens_hsa043601.97954037
3Ether lipid metabolism_Homo sapiens_hsa005651.86825351
4Endometrial cancer_Homo sapiens_hsa052131.85467207
5Nicotine addiction_Homo sapiens_hsa050331.80207285
6Synaptic vesicle cycle_Homo sapiens_hsa047211.78365781
7Morphine addiction_Homo sapiens_hsa050321.76279250
8Glutamatergic synapse_Homo sapiens_hsa047241.75750281
9Non-small cell lung cancer_Homo sapiens_hsa052231.74831793
10Steroid biosynthesis_Homo sapiens_hsa001001.70184615
11Collecting duct acid secretion_Homo sapiens_hsa049661.67102405
12Chronic myeloid leukemia_Homo sapiens_hsa052201.66976822
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.66664158
14Serotonergic synapse_Homo sapiens_hsa047261.66607303
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63810805
16Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.63646152
17Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.62470945
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54246796
19Circadian entrainment_Homo sapiens_hsa047131.53098967
20GABAergic synapse_Homo sapiens_hsa047271.51794890
21Thyroid hormone signaling pathway_Homo sapiens_hsa049191.51464900
22Long-term depression_Homo sapiens_hsa047301.45874560
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42721388
24Prolactin signaling pathway_Homo sapiens_hsa049171.40932413
25mTOR signaling pathway_Homo sapiens_hsa041501.38581445
26Rheumatoid arthritis_Homo sapiens_hsa053231.36109540
27Acute myeloid leukemia_Homo sapiens_hsa052211.35919301
28Autoimmune thyroid disease_Homo sapiens_hsa053201.35682618
29VEGF signaling pathway_Homo sapiens_hsa043701.35297018
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34595610
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33347163
32Fatty acid elongation_Homo sapiens_hsa000621.33125441
33Vibrio cholerae infection_Homo sapiens_hsa051101.31037188
34Estrogen signaling pathway_Homo sapiens_hsa049151.30236644
35Cholinergic synapse_Homo sapiens_hsa047251.28737239
36Olfactory transduction_Homo sapiens_hsa047401.25498700
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22429296
38Adherens junction_Homo sapiens_hsa045201.21995668
39Dopaminergic synapse_Homo sapiens_hsa047281.21815303
40Allograft rejection_Homo sapiens_hsa053301.18831428
41ErbB signaling pathway_Homo sapiens_hsa040121.17971172
42Long-term potentiation_Homo sapiens_hsa047201.17666991
43Renal cell carcinoma_Homo sapiens_hsa052111.17344453
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15449547
45Sphingolipid metabolism_Homo sapiens_hsa006001.10589000
46Salivary secretion_Homo sapiens_hsa049701.10075759
47Chemokine signaling pathway_Homo sapiens_hsa040621.09335079
48MicroRNAs in cancer_Homo sapiens_hsa052061.04372936
49Ras signaling pathway_Homo sapiens_hsa040141.04057006
50Amphetamine addiction_Homo sapiens_hsa050311.03938000
51Renin secretion_Homo sapiens_hsa049241.03878637
52Thyroid cancer_Homo sapiens_hsa052161.03500737
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02880851
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01896462
55FoxO signaling pathway_Homo sapiens_hsa040680.99100822
56Phototransduction_Homo sapiens_hsa047440.98475847
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97322291
58Phagosome_Homo sapiens_hsa041450.96558568
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96333360
60Insulin signaling pathway_Homo sapiens_hsa049100.95643964
61Taste transduction_Homo sapiens_hsa047420.94532476
62MAPK signaling pathway_Homo sapiens_hsa040100.92980906
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.92936528
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92545173
65Small cell lung cancer_Homo sapiens_hsa052220.90955235
66Cocaine addiction_Homo sapiens_hsa050300.90235014
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.89842163
68Proteoglycans in cancer_Homo sapiens_hsa052050.89105485
69Insulin secretion_Homo sapiens_hsa049110.89055350
70cAMP signaling pathway_Homo sapiens_hsa040240.87906270
71Oxytocin signaling pathway_Homo sapiens_hsa049210.87740190
72T cell receptor signaling pathway_Homo sapiens_hsa046600.87716795
73Fatty acid biosynthesis_Homo sapiens_hsa000610.87469771
74Endocytosis_Homo sapiens_hsa041440.87226471
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86551886
76Hepatitis B_Homo sapiens_hsa051610.86016819
77Amoebiasis_Homo sapiens_hsa051460.85913512
78Gastric acid secretion_Homo sapiens_hsa049710.85763089
79Notch signaling pathway_Homo sapiens_hsa043300.83808894
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82990042
81Prion diseases_Homo sapiens_hsa050200.82233409
82Calcium signaling pathway_Homo sapiens_hsa040200.81826339
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81658956
84Platelet activation_Homo sapiens_hsa046110.81245847
85B cell receptor signaling pathway_Homo sapiens_hsa046620.80953116
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80946025
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80337466
88Focal adhesion_Homo sapiens_hsa045100.79694560
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.79681424
90Hepatitis C_Homo sapiens_hsa051600.79319683
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78561238
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78169191
93Dorso-ventral axis formation_Homo sapiens_hsa043200.77774947
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77297969
95HIF-1 signaling pathway_Homo sapiens_hsa040660.76935444
96Toxoplasmosis_Homo sapiens_hsa051450.76921084
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.76837548
98Graft-versus-host disease_Homo sapiens_hsa053320.76157775
99Lysine degradation_Homo sapiens_hsa003100.75223894
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75203327
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.74628326
102Type I diabetes mellitus_Homo sapiens_hsa049400.74068038
103Type II diabetes mellitus_Homo sapiens_hsa049300.74058176
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73501758
105Melanogenesis_Homo sapiens_hsa049160.71856086
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71308610
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71027413
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70725323
109Insulin resistance_Homo sapiens_hsa049310.70257232
110Dilated cardiomyopathy_Homo sapiens_hsa054140.68687003
111Leishmaniasis_Homo sapiens_hsa051400.67870483
112Measles_Homo sapiens_hsa051620.67829283
113Tuberculosis_Homo sapiens_hsa051520.67666542
114Wnt signaling pathway_Homo sapiens_hsa043100.67527676
115Gap junction_Homo sapiens_hsa045400.67511275
116Thyroid hormone synthesis_Homo sapiens_hsa049180.67030669
117AMPK signaling pathway_Homo sapiens_hsa041520.66249124
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66164395
119Tight junction_Homo sapiens_hsa045300.65123008
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64835098
121Inositol phosphate metabolism_Homo sapiens_hsa005620.64776957
122Hedgehog signaling pathway_Homo sapiens_hsa043400.64371428
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.64322139
124Influenza A_Homo sapiens_hsa051640.63055999
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62853309
126GnRH signaling pathway_Homo sapiens_hsa049120.62269644
127Prostate cancer_Homo sapiens_hsa052150.61900676
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61588112
129Salmonella infection_Homo sapiens_hsa051320.60842541
130Glioma_Homo sapiens_hsa052140.59631920
131Rap1 signaling pathway_Homo sapiens_hsa040150.59560779
132Choline metabolism in cancer_Homo sapiens_hsa052310.59453416
133Pancreatic cancer_Homo sapiens_hsa052120.58117363
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.57722202
135Intestinal immune network for IgA production_Homo sapiens_hsa046720.57295403
136Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56776094
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55329244
138Osteoclast differentiation_Homo sapiens_hsa043800.54381360
139Melanoma_Homo sapiens_hsa052180.54044244
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53783382
141Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52346006
142NF-kappa B signaling pathway_Homo sapiens_hsa040640.52344008
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.51118256
144Shigellosis_Homo sapiens_hsa051310.51015258
145Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50191795
146Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48984688
147Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48933535
148Pancreatic secretion_Homo sapiens_hsa049720.48715895
149Colorectal cancer_Homo sapiens_hsa052100.48289516

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