

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 4.82002496 |
| 2 | synaptic vesicle maturation (GO:0016188) | 4.57904933 |
| 3 | vocalization behavior (GO:0071625) | 4.48030774 |
| 4 | locomotory exploration behavior (GO:0035641) | 4.44265644 |
| 5 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.23719259 |
| 6 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.12150137 |
| 7 | synaptic vesicle exocytosis (GO:0016079) | 4.00783172 |
| 8 | glutamate secretion (GO:0014047) | 3.97603829 |
| 9 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.97441807 |
| 10 | layer formation in cerebral cortex (GO:0021819) | 3.93539974 |
| 11 | regulation of synaptic vesicle exocytosis (GO:2000300) | 3.85369782 |
| 12 | neuron cell-cell adhesion (GO:0007158) | 3.83717777 |
| 13 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.81220964 |
| 14 | regulation of synapse structural plasticity (GO:0051823) | 3.78911799 |
| 15 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.74544416 |
| 16 | protein localization to synapse (GO:0035418) | 3.68902483 |
| 17 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.65526650 |
| 18 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.60761317 |
| 19 | exploration behavior (GO:0035640) | 3.52336457 |
| 20 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.48951261 |
| 21 | cell communication by electrical coupling (GO:0010644) | 3.42948242 |
| 22 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 3.40259075 |
| 23 | regulation of synaptic vesicle transport (GO:1902803) | 3.40114617 |
| 24 | dendritic spine morphogenesis (GO:0060997) | 3.38954732 |
| 25 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.38018054 |
| 26 | cell migration in hindbrain (GO:0021535) | 3.35966331 |
| 27 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.35908171 |
| 28 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 3.35276526 |
| 29 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.34962844 |
| 30 | neuron recognition (GO:0008038) | 3.34873343 |
| 31 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.33522680 |
| 32 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 3.32408535 |
| 33 | activation of protein kinase A activity (GO:0034199) | 3.31963820 |
| 34 | dendrite morphogenesis (GO:0048813) | 3.28180916 |
| 35 | neurotransmitter secretion (GO:0007269) | 3.27977705 |
| 36 | proline transport (GO:0015824) | 3.21152747 |
| 37 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.16293789 |
| 38 | axonal fasciculation (GO:0007413) | 3.15632309 |
| 39 | innervation (GO:0060384) | 3.14760369 |
| 40 | cell communication involved in cardiac conduction (GO:0086065) | 3.12487694 |
| 41 | glutamate receptor signaling pathway (GO:0007215) | 3.08613090 |
| 42 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 3.07812460 |
| 43 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.07171169 |
| 44 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.06263167 |
| 45 | synaptic transmission, glutamatergic (GO:0035249) | 3.01820216 |
| 46 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 3.00758321 |
| 47 | neuronal action potential propagation (GO:0019227) | 3.00458912 |
| 48 | establishment of nucleus localization (GO:0040023) | 3.00000830 |
| 49 | neuron-neuron synaptic transmission (GO:0007270) | 2.96903476 |
| 50 | detection of calcium ion (GO:0005513) | 2.93999992 |
| 51 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.92410225 |
| 52 | positive regulation of synapse maturation (GO:0090129) | 2.88976689 |
| 53 | membrane depolarization during action potential (GO:0086010) | 2.87458761 |
| 54 | vesicle transport along microtubule (GO:0047496) | 2.86099831 |
| 55 | regulation of membrane repolarization (GO:0060306) | 2.85662792 |
| 56 | gamma-aminobutyric acid transport (GO:0015812) | 2.83794690 |
| 57 | organelle transport along microtubule (GO:0072384) | 2.83167860 |
| 58 | postsynaptic membrane organization (GO:0001941) | 2.82122474 |
| 59 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 2.81829422 |
| 60 | regulation of postsynaptic membrane potential (GO:0060078) | 2.81458487 |
| 61 | long-term memory (GO:0007616) | 2.81193662 |
| 62 | presynaptic membrane assembly (GO:0097105) | 2.79657069 |
| 63 | neuromuscular process controlling balance (GO:0050885) | 2.76985877 |
| 64 | cellular potassium ion homeostasis (GO:0030007) | 2.76060940 |
| 65 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 2.75970601 |
| 66 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.75893095 |
| 67 | auditory behavior (GO:0031223) | 2.72072530 |
| 68 | regulation of synaptic plasticity (GO:0048167) | 2.71587386 |
| 69 | plasma membrane repair (GO:0001778) | 2.70542551 |
| 70 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.70067628 |
| 71 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.68875326 |
| 72 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 2.67244886 |
| 73 | positive regulation of membrane potential (GO:0045838) | 2.67228714 |
| 74 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.67212397 |
| 75 | sodium ion export (GO:0071436) | 2.66642579 |
| 76 | synaptic vesicle endocytosis (GO:0048488) | 2.65918457 |
| 77 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 2.65496479 |
| 78 | transmission of nerve impulse (GO:0019226) | 2.64497399 |
| 79 | regulation of dendritic spine development (GO:0060998) | 2.64066733 |
| 80 | neuronal ion channel clustering (GO:0045161) | 2.62284125 |
| 81 | cardiac myofibril assembly (GO:0055003) | 2.61748748 |
| 82 | long-term synaptic potentiation (GO:0060291) | 2.61241338 |
| 83 | regulation of cell communication by electrical coupling (GO:0010649) | 2.61144026 |
| 84 | regulation of calcium ion transmembrane transport (GO:1903169) | 2.60590159 |
| 85 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 2.60590159 |
| 86 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.59737009 |
| 87 | axon extension (GO:0048675) | 2.59500787 |
| 88 | neurotransmitter transport (GO:0006836) | 2.57094512 |
| 89 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 2.56918423 |
| 90 | synapse assembly (GO:0007416) | 2.56401460 |
| 91 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.56130866 |
| 92 | cerebellar granule cell differentiation (GO:0021707) | 2.56070164 |
| 93 | positive regulation of potassium ion transport (GO:0043268) | 2.54958449 |
| 94 | membrane repolarization during cardiac muscle cell action potential (GO:0086013) | 2.54679021 |
| 95 | nucleobase catabolic process (GO:0046113) | 2.54088893 |
| 96 | response to auditory stimulus (GO:0010996) | 2.54079835 |
| 97 | membrane depolarization (GO:0051899) | 2.53750673 |
| 98 | central nervous system myelination (GO:0022010) | 2.53071359 |
| 99 | axon ensheathment in central nervous system (GO:0032291) | 2.53071359 |
| 100 | regulation of neurotransmitter secretion (GO:0046928) | 2.52301987 |
| 101 | synapse organization (GO:0050808) | 2.51751117 |
| 102 | actin-myosin filament sliding (GO:0033275) | 2.51715810 |
| 103 | muscle filament sliding (GO:0030049) | 2.51715810 |
| 104 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.51629907 |
| 105 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 2.50631517 |
| 106 | presynaptic membrane organization (GO:0097090) | 2.48711952 |
| 107 | regulation of potassium ion transmembrane transport (GO:1901379) | 2.48709371 |
| 108 | positive regulation of synapse assembly (GO:0051965) | 2.47259596 |
| 109 | myofibril assembly (GO:0030239) | 2.46883490 |
| 110 | establishment of mitochondrion localization (GO:0051654) | 2.46096084 |
| 111 | negative regulation of protein localization to cell surface (GO:2000009) | 2.43235349 |
| 112 | neuromuscular synaptic transmission (GO:0007274) | 2.42842222 |
| 113 | regulation of synapse assembly (GO:0051963) | 2.39167927 |
| 114 | peripheral nervous system axon ensheathment (GO:0032292) | 2.38887380 |
| 115 | myelination in peripheral nervous system (GO:0022011) | 2.38887380 |
| 116 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339) | 2.36938564 |
| 117 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 2.34381795 |
| 118 | regulation of axon extension involved in axon guidance (GO:0048841) | 2.33437740 |
| 119 | actin-mediated cell contraction (GO:0070252) | 2.33436232 |
| 120 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.32160303 |
| 121 | neuron projection extension (GO:1990138) | 2.30956152 |
| 122 | regulation of axon guidance (GO:1902667) | 2.29446815 |
| 123 | myoblast fusion (GO:0007520) | 2.27299131 |
| 124 | membrane assembly (GO:0071709) | 2.22431975 |
| 125 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.20815182 |
| 126 | embryonic retina morphogenesis in camera-type eye (GO:0060059) | 2.20169049 |
| 127 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.18315425 |
| 128 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 2.18149626 |
| 129 | positive regulation of dendritic spine development (GO:0060999) | 2.15528870 |
| 130 | sarcomere organization (GO:0045214) | 2.13027843 |
| 131 | regulation of synapse maturation (GO:0090128) | 2.12912209 |
| 132 | cerebral cortex radially oriented cell migration (GO:0021799) | 2.11312186 |
| 133 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 2.11197324 |
| 134 | camera-type eye morphogenesis (GO:0048593) | 2.10438444 |
| 135 | dendritic spine organization (GO:0097061) | 2.09603237 |
| 136 | short-term memory (GO:0007614) | 2.09312778 |
| 137 | protein heterotrimerization (GO:0070208) | 2.06747583 |
| 138 | regulation of synapse organization (GO:0050807) | 2.06022217 |
| 139 | regulation of respiratory system process (GO:0044065) | 2.05110093 |
| 140 | cerebellar Purkinje cell layer development (GO:0021680) | 2.04635448 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.88616579 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.49089648 |
| 3 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.70308603 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.68723111 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.51856011 |
| 6 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.38088011 |
| 7 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.38088011 |
| 8 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.24021668 |
| 9 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.19207395 |
| 10 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.19073380 |
| 11 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.18991001 |
| 12 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.16339928 |
| 13 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.14910275 |
| 14 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.11706179 |
| 15 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.11329031 |
| 16 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.06557250 |
| 17 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.04820905 |
| 18 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 2.04023030 |
| 19 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.95471206 |
| 20 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.90871440 |
| 21 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.89863581 |
| 22 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.86877563 |
| 23 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.80808518 |
| 24 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.78997274 |
| 25 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.78442065 |
| 26 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.72304477 |
| 27 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.65260285 |
| 28 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.64405542 |
| 29 | * SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.63333140 |
| 30 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.61304103 |
| 31 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.54956414 |
| 32 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.50116745 |
| 33 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.49905820 |
| 34 | * ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.48318499 |
| 35 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.48198402 |
| 36 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.47757875 |
| 37 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.47363476 |
| 38 | * EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.45122000 |
| 39 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.44706841 |
| 40 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.44391660 |
| 41 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.43375486 |
| 42 | * SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.40881120 |
| 43 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.40570869 |
| 44 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.40394615 |
| 45 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.39586857 |
| 46 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.38375541 |
| 47 | * SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.36422253 |
| 48 | P300_19829295_ChIP-Seq_ESCs_Human | 1.36340510 |
| 49 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.35104509 |
| 50 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.34324452 |
| 51 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.34006484 |
| 52 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.33954037 |
| 53 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.33661054 |
| 54 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.33080076 |
| 55 | * OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.31083691 |
| 56 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.30616737 |
| 57 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.27599927 |
| 58 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.27012470 |
| 59 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.26957179 |
| 60 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.25818800 |
| 61 | * AR_19668381_ChIP-Seq_PC3_Human | 1.25351840 |
| 62 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.25219316 |
| 63 | AR_25329375_ChIP-Seq_VCAP_Human | 1.25054726 |
| 64 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.20326094 |
| 65 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.19943158 |
| 66 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.19539561 |
| 67 | * POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.17769404 |
| 68 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.17749420 |
| 69 | TCF4_23295773_ChIP-Seq_U87_Human | 1.17680809 |
| 70 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.17415279 |
| 71 | TP53_16413492_ChIP-PET_HCT116_Human | 1.16457052 |
| 72 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.15146573 |
| 73 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.15081166 |
| 74 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.14183692 |
| 75 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.14028554 |
| 76 | * YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.13855752 |
| 77 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.12262230 |
| 78 | * TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.11928037 |
| 79 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.11565970 |
| 80 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.11431348 |
| 81 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.10881226 |
| 82 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.10173034 |
| 83 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.07662458 |
| 84 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.05982450 |
| 85 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.05776588 |
| 86 | * SMAD4_21741376_ChIP-Seq_HESCs_Human | 1.04854970 |
| 87 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.04829540 |
| 88 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.04504348 |
| 89 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.04228465 |
| 90 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.02835607 |
| 91 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.02832555 |
| 92 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.01017065 |
| 93 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.00465655 |
| 94 | * TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.00341625 |
| 95 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.00120728 |
| 96 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.99801382 |
| 97 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.99654565 |
| 98 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.98973558 |
| 99 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.98265271 |
| 100 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.98125850 |
| 101 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.97827824 |
| 102 | KDM2B_26808549_Chip-Seq_K562_Human | 0.97639638 |
| 103 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.97175078 |
| 104 | * RUNX2_22187159_ChIP-Seq_PCA_Human | 0.97126942 |
| 105 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.96918262 |
| 106 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 0.96690569 |
| 107 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.96490869 |
| 108 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.96490869 |
| 109 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.95382180 |
| 110 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 0.95301239 |
| 111 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.93729667 |
| 112 | KDM2B_26808549_Chip-Seq_REH_Human | 0.92977208 |
| 113 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.92154322 |
| 114 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.91723058 |
| 115 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.91679867 |
| 116 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.90045551 |
| 117 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.89880621 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.25337626 |
| 2 | MP0004270_analgesia | 3.85599850 |
| 3 | MP0003880_abnormal_central_pattern | 3.50111528 |
| 4 | MP0003635_abnormal_synaptic_transmissio | 3.40122731 |
| 5 | MP0002063_abnormal_learning/memory/cond | 2.80656249 |
| 6 | MP0002837_dystrophic_cardiac_calcinosis | 2.80616251 |
| 7 | MP0009745_abnormal_behavioral_response | 2.61156633 |
| 8 | MP0009780_abnormal_chondrocyte_physiolo | 2.57262457 |
| 9 | MP0002734_abnormal_mechanical_nocicepti | 2.47100134 |
| 10 | MP0009046_muscle_twitch | 2.44949835 |
| 11 | MP0001968_abnormal_touch/_nociception | 2.44596595 |
| 12 | MP0002064_seizures | 2.42427548 |
| 13 | MP0002735_abnormal_chemical_nociception | 2.32553209 |
| 14 | MP0000751_myopathy | 2.25608567 |
| 15 | MP0008438_abnormal_cutaneous_collagen | 2.23790096 |
| 16 | MP0002572_abnormal_emotion/affect_behav | 2.21974992 |
| 17 | MP0002822_catalepsy | 2.10753227 |
| 18 | MP0005423_abnormal_somatic_nervous | 2.10439818 |
| 19 | MP0004858_abnormal_nervous_system | 2.06557674 |
| 20 | MP0002272_abnormal_nervous_system | 2.02917586 |
| 21 | MP0001486_abnormal_startle_reflex | 1.95475526 |
| 22 | MP0004215_abnormal_myocardial_fiber | 1.95002664 |
| 23 | MP0000778_abnormal_nervous_system | 1.93776654 |
| 24 | MP0002736_abnormal_nociception_after | 1.87015699 |
| 25 | MP0002909_abnormal_adrenal_gland | 1.76752233 |
| 26 | MP0001440_abnormal_grooming_behavior | 1.76545146 |
| 27 | MP0002184_abnormal_innervation | 1.73065377 |
| 28 | MP0002733_abnormal_thermal_nociception | 1.69794133 |
| 29 | MP0002067_abnormal_sensory_capabilities | 1.65287079 |
| 30 | MP0005386_behavior/neurological_phenoty | 1.63308413 |
| 31 | MP0004924_abnormal_behavior | 1.63308413 |
| 32 | MP0004811_abnormal_neuron_physiology | 1.62788795 |
| 33 | MP0004084_abnormal_cardiac_muscle | 1.60669651 |
| 34 | MP0001970_abnormal_pain_threshold | 1.60139449 |
| 35 | MP0005503_abnormal_tendon_morphology | 1.58917824 |
| 36 | MP0003329_amyloid_beta_deposits | 1.56357084 |
| 37 | MP0000955_abnormal_spinal_cord | 1.47352753 |
| 38 | MP0001501_abnormal_sleep_pattern | 1.42916642 |
| 39 | MP0004036_abnormal_muscle_relaxation | 1.40106613 |
| 40 | MP0004085_abnormal_heartbeat | 1.38671802 |
| 41 | MP0002108_abnormal_muscle_morphology | 1.37386541 |
| 42 | MP0002557_abnormal_social/conspecific_i | 1.37329593 |
| 43 | MP0003137_abnormal_impulse_conducting | 1.36483923 |
| 44 | MP0004885_abnormal_endolymph | 1.36468290 |
| 45 | MP0008569_lethality_at_weaning | 1.36064922 |
| 46 | MP0000534_abnormal_ureter_morphology | 1.35161024 |
| 47 | MP0004145_abnormal_muscle_electrophysio | 1.34241242 |
| 48 | MP0000569_abnormal_digit_pigmentation | 1.33495459 |
| 49 | MP0006276_abnormal_autonomic_nervous | 1.31273875 |
| 50 | MP0003646_muscle_fatigue | 1.30353659 |
| 51 | MP0004130_abnormal_muscle_cell | 1.30263119 |
| 52 | MP0002882_abnormal_neuron_morphology | 1.29041637 |
| 53 | MP0001984_abnormal_olfaction | 1.28860606 |
| 54 | MP0005257_abnormal_intraocular_pressure | 1.28464608 |
| 55 | MP0000566_synostosis | 1.26069399 |
| 56 | MP0001958_emphysema | 1.24079108 |
| 57 | MP0004272_abnormal_basement_membrane | 1.23571320 |
| 58 | MP0005275_abnormal_skin_tensile | 1.22037977 |
| 59 | MP0004484_altered_response_of | 1.21878808 |
| 60 | MP0002066_abnormal_motor_capabilities/c | 1.19930036 |
| 61 | MP0010030_abnormal_orbit_morphology | 1.19342802 |
| 62 | MP0002972_abnormal_cardiac_muscle | 1.17777699 |
| 63 | MP0002638_abnormal_pupillary_reflex | 1.17747339 |
| 64 | MP0004233_abnormal_muscle_weight | 1.17724528 |
| 65 | MP0001299_abnormal_eye_distance/ | 1.17320240 |
| 66 | MP0005620_abnormal_muscle_contractility | 1.17020302 |
| 67 | MP0005171_absent_coat_pigmentation | 1.15570005 |
| 68 | MP0003136_yellow_coat_color | 1.15298362 |
| 69 | MP0000013_abnormal_adipose_tissue | 1.14189272 |
| 70 | MP0005623_abnormal_meninges_morphology | 1.13307435 |
| 71 | MP0005646_abnormal_pituitary_gland | 1.12505407 |
| 72 | MP0003633_abnormal_nervous_system | 1.12305174 |
| 73 | MP0003283_abnormal_digestive_organ | 1.07565937 |
| 74 | MP0005670_abnormal_white_adipose | 1.07392581 |
| 75 | MP0004087_abnormal_muscle_fiber | 1.06821832 |
| 76 | MP0003879_abnormal_hair_cell | 1.06069781 |
| 77 | MP0000749_muscle_degeneration | 1.05334463 |
| 78 | MP0003942_abnormal_urinary_system | 1.04226536 |
| 79 | MP0003787_abnormal_imprinting | 1.03968416 |
| 80 | MP0005330_cardiomyopathy | 1.03388701 |
| 81 | MP0004510_myositis | 1.02285634 |
| 82 | MP0010368_abnormal_lymphatic_system | 1.02021910 |
| 83 | MP0002152_abnormal_brain_morphology | 0.98416790 |
| 84 | MP0003631_nervous_system_phenotype | 0.96898412 |
| 85 | MP0003634_abnormal_glial_cell | 0.94723296 |
| 86 | MP0000747_muscle_weakness | 0.94039743 |
| 87 | MP0005187_abnormal_penis_morphology | 0.93408353 |
| 88 | MP0001502_abnormal_circadian_rhythm | 0.91423517 |
| 89 | MP0009384_cardiac_valve_regurgitation | 0.91141812 |
| 90 | MP0003122_maternal_imprinting | 0.90644083 |
| 91 | MP0000049_abnormal_middle_ear | 0.90117912 |
| 92 | MP0002249_abnormal_larynx_morphology | 0.89915739 |
| 93 | MP0003705_abnormal_hypodermis_morpholog | 0.89124865 |
| 94 | MP0009250_abnormal_appendicular_skeleto | 0.88788408 |
| 95 | MP0010386_abnormal_urinary_bladder | 0.88347443 |
| 96 | MP0005645_abnormal_hypothalamus_physiol | 0.87907025 |
| 97 | MP0001177_atelectasis | 0.87422122 |
| 98 | MP0008775_abnormal_heart_ventricle | 0.87104337 |
| 99 | MP0000733_abnormal_muscle_development | 0.87058705 |
| 100 | MP0002234_abnormal_pharynx_morphology | 0.86616711 |
| 101 | MP0002229_neurodegeneration | 0.85929801 |
| 102 | MP0005409_darkened_coat_color | 0.85419580 |
| 103 | MP0006138_congestive_heart_failure | 0.84742685 |
| 104 | MP0003279_aneurysm | 0.83648217 |
| 105 | MP0002090_abnormal_vision | 0.83206819 |
| 106 | MP0003755_abnormal_palate_morphology | 0.82612904 |
| 107 | MP0000631_abnormal_neuroendocrine_gland | 0.82477362 |
| 108 | MP0003385_abnormal_body_wall | 0.81887137 |
| 109 | MP0001529_abnormal_vocalization | 0.81780875 |
| 110 | MP0002269_muscular_atrophy | 0.80663971 |
| 111 | MP0000750_abnormal_muscle_regeneration | 0.79863576 |
| 112 | MP0000003_abnormal_adipose_tissue | 0.79775569 |
| 113 | MP0002106_abnormal_muscle_physiology | 0.78481416 |
| 114 | MP0002127_abnormal_cardiovascular_syste | 0.76991277 |
| 115 | MP0000759_abnormal_skeletal_muscle | 0.76654929 |
| 116 | MP0003632_abnormal_nervous_system | 0.75546002 |
| 117 | MP0004142_abnormal_muscle_tone | 0.74342280 |
| 118 | MP0005551_abnormal_eye_electrophysiolog | 0.74107162 |
| 119 | MP0005369_muscle_phenotype | 0.72851870 |
| 120 | MP0000920_abnormal_myelination | 0.71827675 |
| 121 | MP0003690_abnormal_glial_cell | 0.71789699 |
| 122 | MP0005535_abnormal_body_temperature | 0.71779690 |
| 123 | MP0002069_abnormal_eating/drinking_beha | 0.71694732 |
| 124 | MP0008961_abnormal_basal_metabolism | 0.69030338 |
| 125 | MP0002752_abnormal_somatic_nervous | 0.67535052 |
| 126 | MP0005248_abnormal_Harderian_gland | 0.67193138 |
| 127 | MP0001544_abnormal_cardiovascular_syste | 0.66164245 |
| 128 | MP0005385_cardiovascular_system_phenoty | 0.66164245 |
| 129 | MP0004742_abnormal_vestibular_system | 0.66072988 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 5.27755984 |
| 2 | Myokymia (HP:0002411) | 4.86786837 |
| 3 | Focal seizures (HP:0007359) | 4.32205459 |
| 4 | Type 1 muscle fiber predominance (HP:0003803) | 4.08276671 |
| 5 | Atonic seizures (HP:0010819) | 3.54298034 |
| 6 | Action tremor (HP:0002345) | 3.54270881 |
| 7 | Visual hallucinations (HP:0002367) | 3.51760648 |
| 8 | Epileptic encephalopathy (HP:0200134) | 3.48528542 |
| 9 | Sudden death (HP:0001699) | 3.45939131 |
| 10 | Muscle fiber inclusion bodies (HP:0100299) | 3.35619396 |
| 11 | Termporal pattern (HP:0011008) | 3.34162822 |
| 12 | Insidious onset (HP:0003587) | 3.34162822 |
| 13 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 3.29931334 |
| 14 | Progressive cerebellar ataxia (HP:0002073) | 3.27638157 |
| 15 | Nemaline bodies (HP:0003798) | 3.23489448 |
| 16 | Febrile seizures (HP:0002373) | 3.19300145 |
| 17 | Pheochromocytoma (HP:0002666) | 3.08854427 |
| 18 | Absence seizures (HP:0002121) | 3.06582971 |
| 19 | Hyperventilation (HP:0002883) | 3.02194158 |
| 20 | Ankle clonus (HP:0011448) | 2.87673822 |
| 21 | Generalized tonic-clonic seizures (HP:0002069) | 2.83301824 |
| 22 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.79683728 |
| 23 | Supranuclear gaze palsy (HP:0000605) | 2.79160358 |
| 24 | Dialeptic seizures (HP:0011146) | 2.76356361 |
| 25 | Syncope (HP:0001279) | 2.65499968 |
| 26 | Dysdiadochokinesis (HP:0002075) | 2.64146529 |
| 27 | Abnormality of the corticospinal tract (HP:0002492) | 2.62640431 |
| 28 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.62500783 |
| 29 | Excessive salivation (HP:0003781) | 2.61621072 |
| 30 | Drooling (HP:0002307) | 2.61621072 |
| 31 | Poor eye contact (HP:0000817) | 2.58364210 |
| 32 | Broad-based gait (HP:0002136) | 2.57751641 |
| 33 | Neuroendocrine neoplasm (HP:0100634) | 2.56217873 |
| 34 | Impaired social interactions (HP:0000735) | 2.55577703 |
| 35 | Abnormal social behavior (HP:0012433) | 2.55577703 |
| 36 | Atrial fibrillation (HP:0005110) | 2.53855757 |
| 37 | Prolonged QT interval (HP:0001657) | 2.53249074 |
| 38 | Abnormality of the lower motor neuron (HP:0002366) | 2.50608412 |
| 39 | Primary atrial arrhythmia (HP:0001692) | 2.47724676 |
| 40 | Bundle branch block (HP:0011710) | 2.46841928 |
| 41 | Protrusio acetabuli (HP:0003179) | 2.45270308 |
| 42 | Urinary urgency (HP:0000012) | 2.45270263 |
| 43 | Dysmetric saccades (HP:0000641) | 2.44486326 |
| 44 | Shallow orbits (HP:0000586) | 2.43202202 |
| 45 | Ventricular fibrillation (HP:0001663) | 2.42800730 |
| 46 | Depression (HP:0000716) | 2.41401158 |
| 47 | Spinal rigidity (HP:0003306) | 2.40903073 |
| 48 | Truncal ataxia (HP:0002078) | 2.39692164 |
| 49 | Genetic anticipation (HP:0003743) | 2.38241099 |
| 50 | Premature rupture of membranes (HP:0001788) | 2.36283989 |
| 51 | Round ear (HP:0100830) | 2.33342863 |
| 52 | Amblyopia (HP:0000646) | 2.32990862 |
| 53 | Blue irides (HP:0000635) | 2.32634296 |
| 54 | Dysmetria (HP:0001310) | 2.32175272 |
| 55 | Cerebral inclusion bodies (HP:0100314) | 2.30125087 |
| 56 | Abnormality of the calf musculature (HP:0001430) | 2.30022920 |
| 57 | Distal arthrogryposis (HP:0005684) | 2.28917181 |
| 58 | Epileptiform EEG discharges (HP:0011182) | 2.28214759 |
| 59 | Gaze-evoked nystagmus (HP:0000640) | 2.27217118 |
| 60 | Lower limb amyotrophy (HP:0007210) | 2.27006106 |
| 61 | Exercise-induced myalgia (HP:0003738) | 2.25347993 |
| 62 | Supraventricular tachycardia (HP:0004755) | 2.25285980 |
| 63 | Postural instability (HP:0002172) | 2.24942393 |
| 64 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.24768956 |
| 65 | Broad metatarsal (HP:0001783) | 2.24464772 |
| 66 | Calf muscle hypertrophy (HP:0008981) | 2.24391444 |
| 67 | Lower limb muscle weakness (HP:0007340) | 2.23642641 |
| 68 | EEG with generalized epileptiform discharges (HP:0011198) | 2.22777800 |
| 69 | Supraventricular arrhythmia (HP:0005115) | 2.21476903 |
| 70 | Anxiety (HP:0000739) | 2.20264221 |
| 71 | Abnormal EKG (HP:0003115) | 2.18944586 |
| 72 | Muscle fiber splitting (HP:0003555) | 2.18459451 |
| 73 | Hypsarrhythmia (HP:0002521) | 2.16501464 |
| 74 | Spastic gait (HP:0002064) | 2.14024453 |
| 75 | Neurofibrillary tangles (HP:0002185) | 2.13799524 |
| 76 | Limb-girdle muscle weakness (HP:0003325) | 2.11383711 |
| 77 | Fetal akinesia sequence (HP:0001989) | 2.10688328 |
| 78 | Hyporeflexia of lower limbs (HP:0002600) | 2.10289091 |
| 79 | Mutism (HP:0002300) | 2.09840661 |
| 80 | Muscle hypertrophy of the lower extremities (HP:0008968) | 2.08399081 |
| 81 | Scanning speech (HP:0002168) | 2.04816315 |
| 82 | Torticollis (HP:0000473) | 2.02126830 |
| 83 | Akinesia (HP:0002304) | 1.99431122 |
| 84 | Difficulty running (HP:0009046) | 1.96386814 |
| 85 | Megalencephaly (HP:0001355) | 1.95746368 |
| 86 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.94753657 |
| 87 | Hammertoe (HP:0001765) | 1.94638712 |
| 88 | Abnormal eating behavior (HP:0100738) | 1.94323278 |
| 89 | Limited hip movement (HP:0008800) | 1.94219553 |
| 90 | Calcaneovalgus deformity (HP:0001848) | 1.94067614 |
| 91 | Coronal craniosynostosis (HP:0004440) | 1.92923115 |
| 92 | Neonatal short-limb short stature (HP:0008921) | 1.92496981 |
| 93 | Intention tremor (HP:0002080) | 1.91740312 |
| 94 | Myotonia (HP:0002486) | 1.91472282 |
| 95 | Ventricular arrhythmia (HP:0004308) | 1.90268384 |
| 96 | Agitation (HP:0000713) | 1.89547179 |
| 97 | Slender build (HP:0001533) | 1.89398919 |
| 98 | Limb dystonia (HP:0002451) | 1.89259871 |
| 99 | Papilledema (HP:0001085) | 1.88359840 |
| 100 | Turricephaly (HP:0000262) | 1.86117221 |
| 101 | Abnormality of skeletal muscle fiber size (HP:0012084) | 1.85561715 |
| 102 | Neoplasm of the peripheral nervous system (HP:0100007) | 1.85539340 |
| 103 | Progressive inability to walk (HP:0002505) | 1.85474774 |
| 104 | Neoplasm of the heart (HP:0100544) | 1.85467645 |
| 105 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.84809139 |
| 106 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.84809139 |
| 107 | Rapidly progressive (HP:0003678) | 1.84145846 |
| 108 | Bradycardia (HP:0001662) | 1.83667079 |
| 109 | Deformed tarsal bones (HP:0008119) | 1.80623199 |
| 110 | Bradykinesia (HP:0002067) | 1.78548972 |
| 111 | Macroorchidism (HP:0000053) | 1.78188193 |
| 112 | Aortic dissection (HP:0002647) | 1.77543576 |
| 113 | Ulnar deviation of the wrist (HP:0003049) | 1.77469462 |
| 114 | Resting tremor (HP:0002322) | 1.77247386 |
| 115 | Abnormality of the ischium (HP:0003174) | 1.76691633 |
| 116 | Wide anterior fontanel (HP:0000260) | 1.76672601 |
| 117 | Hemiparesis (HP:0001269) | 1.76559232 |
| 118 | Stereotypic behavior (HP:0000733) | 1.76363950 |
| 119 | Abnormality of dentin (HP:0010299) | 1.76292890 |
| 120 | EMG: myopathic abnormalities (HP:0003458) | 1.76284781 |
| 121 | Focal dystonia (HP:0004373) | 1.75949701 |
| 122 | Central scotoma (HP:0000603) | 1.75665534 |
| 123 | Aqueductal stenosis (HP:0002410) | 1.75156394 |
| 124 | Absent speech (HP:0001344) | 1.74084250 |
| 125 | Exercise-induced muscle cramps (HP:0003710) | 1.73056312 |
| 126 | Impaired smooth pursuit (HP:0007772) | 1.71626558 |
| 127 | Hip contracture (HP:0003273) | 1.71473036 |
| 128 | Impaired vibratory sensation (HP:0002495) | 1.71444628 |
| 129 | Infantile muscular hypotonia (HP:0008947) | 1.69594943 |
| 130 | Frequent falls (HP:0002359) | 1.69344371 |
| 131 | Increased variability in muscle fiber diameter (HP:0003557) | 1.69008716 |
| 132 | Hypoventilation (HP:0002791) | 1.68917496 |
| 133 | Vascular tortuosity (HP:0004948) | 1.68771262 |
| 134 | Obstructive sleep apnea (HP:0002870) | 1.68411427 |
| 135 | Aortic aneurysm (HP:0004942) | 1.68019965 |
| 136 | Rimmed vacuoles (HP:0003805) | 1.67692991 |
| 137 | Scapular winging (HP:0003691) | 1.66285242 |
| 138 | Soft skin (HP:0000977) | 1.63389109 |
| 139 | Lymphangioma (HP:0100764) | 1.63334771 |
| 140 | Abnormality of the aortic arch (HP:0012303) | 1.63227762 |
| 141 | Wrist flexion contracture (HP:0001239) | 1.62394499 |
| 142 | Increased connective tissue (HP:0009025) | 1.62178356 |
| 143 | Hypoplastic ischia (HP:0003175) | 1.61642879 |
| 144 | Proximal amyotrophy (HP:0007126) | 1.60231692 |
| 145 | Overgrowth (HP:0001548) | 1.59471342 |
| 146 | Bladder diverticulum (HP:0000015) | 1.59129067 |
| 147 | Sleep apnea (HP:0010535) | 1.58177513 |
| 148 | Ankle contracture (HP:0006466) | 1.56568769 |
| 149 | Bowel diverticulosis (HP:0005222) | 1.55384727 |
| 150 | Arterial tortuosity (HP:0005116) | 1.53846230 |
| 151 | Buphthalmos (HP:0000557) | 1.52952325 |
| 152 | Absent phalangeal crease (HP:0006109) | 1.49573390 |
| 153 | Cerebral aneurysm (HP:0004944) | 1.48724755 |
| 154 | Vertebral arch anomaly (HP:0008438) | 1.48708001 |
| 155 | Aplasia involving bones of the extremities (HP:0009825) | 1.47168657 |
| 156 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.47168657 |
| 157 | Aplasia of the phalanges of the hand (HP:0009802) | 1.47168657 |
| 158 | Polyphagia (HP:0002591) | 1.47059708 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 3.88492248 |
| 2 | MARK1 | 3.74192619 |
| 3 | EPHA4 | 3.22075964 |
| 4 | MAP3K9 | 3.18047432 |
| 5 | MAP3K4 | 2.79060820 |
| 6 | PRKD3 | 2.39639330 |
| 7 | MINK1 | 2.37813823 |
| 8 | PAK6 | 2.04960294 |
| 9 | MAP2K7 | 2.00340325 |
| 10 | CASK | 1.93988484 |
| 11 | KSR2 | 1.92893505 |
| 12 | DAPK2 | 1.89032339 |
| 13 | PHKG1 | 1.87459142 |
| 14 | PHKG2 | 1.87459142 |
| 15 | NTRK2 | 1.85611412 |
| 16 | NTRK1 | 1.81410329 |
| 17 | STK38L | 1.80125221 |
| 18 | KSR1 | 1.79006518 |
| 19 | MAP2K4 | 1.74543780 |
| 20 | EPHB2 | 1.61084371 |
| 21 | MAP3K2 | 1.55014710 |
| 22 | LATS2 | 1.46864202 |
| 23 | PLK2 | 1.45896514 |
| 24 | MAPK13 | 1.36539843 |
| 25 | CAMKK1 | 1.35726754 |
| 26 | CDK5 | 1.33567785 |
| 27 | LMTK2 | 1.31295044 |
| 28 | EPHA3 | 1.30817963 |
| 29 | PAK3 | 1.21998565 |
| 30 | LIMK1 | 1.19698242 |
| 31 | RIPK4 | 1.16562837 |
| 32 | RET | 1.13476859 |
| 33 | SGK223 | 1.13065860 |
| 34 | SGK494 | 1.13065860 |
| 35 | SGK2 | 1.11356704 |
| 36 | MYLK | 1.10672114 |
| 37 | MUSK | 1.07376798 |
| 38 | CAMK1G | 1.04265501 |
| 39 | DMPK | 1.01997466 |
| 40 | GRK5 | 1.00388238 |
| 41 | PRKCH | 1.00385694 |
| 42 | STK38 | 0.99843689 |
| 43 | PNCK | 0.98676870 |
| 44 | CAMK2A | 0.98671586 |
| 45 | SGK3 | 0.96418688 |
| 46 | MAP4K2 | 0.95889114 |
| 47 | CAMK2G | 0.95856209 |
| 48 | PTK2 | 0.93419244 |
| 49 | ICK | 0.92689582 |
| 50 | TYRO3 | 0.92471045 |
| 51 | PRPF4B | 0.89223187 |
| 52 | TAOK1 | 0.88676786 |
| 53 | UHMK1 | 0.88531828 |
| 54 | RIPK1 | 0.87199398 |
| 55 | AKT3 | 0.86800689 |
| 56 | DAPK1 | 0.85660124 |
| 57 | SIK2 | 0.82277425 |
| 58 | PRKCG | 0.81894496 |
| 59 | MARK2 | 0.81347388 |
| 60 | MAP3K12 | 0.81021689 |
| 61 | LATS1 | 0.79738292 |
| 62 | WNK1 | 0.79408127 |
| 63 | FER | 0.77449163 |
| 64 | FGFR2 | 0.75921441 |
| 65 | PRKCE | 0.75395818 |
| 66 | PDGFRA | 0.74777086 |
| 67 | PAK2 | 0.74729838 |
| 68 | PTK2B | 0.74416203 |
| 69 | CDC42BPA | 0.73617813 |
| 70 | STK11 | 0.72276354 |
| 71 | PDK3 | 0.71950762 |
| 72 | PDK4 | 0.71950762 |
| 73 | SGK1 | 0.71600841 |
| 74 | CSNK1G2 | 0.71304424 |
| 75 | PRKD2 | 0.70204968 |
| 76 | DYRK1B | 0.69573978 |
| 77 | CAMKK2 | 0.69142739 |
| 78 | DYRK2 | 0.68563225 |
| 79 | INSRR | 0.68390309 |
| 80 | CAMK2D | 0.68389800 |
| 81 | WNK3 | 0.66648674 |
| 82 | TTN | 0.66308812 |
| 83 | TESK1 | 0.64902530 |
| 84 | CAMK2B | 0.64344678 |
| 85 | DYRK1A | 0.63397741 |
| 86 | CDK14 | 0.61804030 |
| 87 | DDR2 | 0.61673601 |
| 88 | CDK18 | 0.60746668 |
| 89 | CSNK1G1 | 0.60613391 |
| 90 | ARAF | 0.60557956 |
| 91 | RPS6KA2 | 0.60084811 |
| 92 | PINK1 | 0.59533834 |
| 93 | CAMK1 | 0.59189246 |
| 94 | FRK | 0.58860699 |
| 95 | STK39 | 0.58024118 |
| 96 | CDK15 | 0.56990933 |
| 97 | ROCK1 | 0.56878029 |
| 98 | ERBB3 | 0.56688479 |
| 99 | PRKCZ | 0.56500056 |
| 100 | WNK4 | 0.55012692 |
| 101 | MAP2K1 | 0.54877327 |
| 102 | MAPK12 | 0.54484922 |
| 103 | MET | 0.54240686 |
| 104 | OBSCN | 0.54148689 |
| 105 | PIK3CA | 0.54071029 |
| 106 | PDPK1 | 0.53757000 |
| 107 | TNIK | 0.53581425 |
| 108 | PKN1 | 0.53027475 |
| 109 | PKN2 | 0.52938046 |
| 110 | CSNK1A1L | 0.52621786 |
| 111 | RAF1 | 0.52174858 |
| 112 | MAP3K1 | 0.51845932 |
| 113 | PRKG1 | 0.51482678 |
| 114 | CSNK1G3 | 0.51088222 |
| 115 | SIK1 | 0.50173339 |
| 116 | RPS6KA3 | 0.49480561 |
| 117 | NEK9 | 0.49422261 |
| 118 | PDK1 | 0.48957426 |
| 119 | ROCK2 | 0.47919414 |
| 120 | MAP3K6 | 0.47565895 |
| 121 | MTOR | 0.47322621 |
| 122 | BCR | 0.47233915 |
| 123 | TRIB3 | 0.46797302 |
| 124 | SCYL2 | 0.45557775 |
| 125 | PRKD1 | 0.44183022 |
| 126 | CDK11A | 0.44035975 |
| 127 | MAP3K7 | 0.43592923 |
| 128 | CAMK4 | 0.42994531 |
| 129 | ALK | 0.42640828 |
| 130 | PRKAA1 | 0.41670226 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 2.60224308 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.50364144 |
| 3 | Circadian entrainment_Homo sapiens_hsa04713 | 2.28458231 |
| 4 | Olfactory transduction_Homo sapiens_hsa04740 | 2.26875090 |
| 5 | Long-term potentiation_Homo sapiens_hsa04720 | 2.18767943 |
| 6 | GABAergic synapse_Homo sapiens_hsa04727 | 2.18111755 |
| 7 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.13185116 |
| 8 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.06652177 |
| 9 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.98907237 |
| 10 | Morphine addiction_Homo sapiens_hsa05032 | 1.97168452 |
| 11 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.88710077 |
| 12 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.87950607 |
| 13 | Insulin secretion_Homo sapiens_hsa04911 | 1.85973328 |
| 14 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.80144949 |
| 15 | Salivary secretion_Homo sapiens_hsa04970 | 1.72988845 |
| 16 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.70186865 |
| 17 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.60010122 |
| 18 | Renin secretion_Homo sapiens_hsa04924 | 1.57199758 |
| 19 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.55553564 |
| 20 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.50935706 |
| 21 | Taste transduction_Homo sapiens_hsa04742 | 1.50547234 |
| 22 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.50266384 |
| 23 | Circadian rhythm_Homo sapiens_hsa04710 | 1.48834603 |
| 24 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.47500882 |
| 25 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.39983092 |
| 26 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.39108574 |
| 27 | Long-term depression_Homo sapiens_hsa04730 | 1.37035912 |
| 28 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.36986893 |
| 29 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.36275292 |
| 30 | Axon guidance_Homo sapiens_hsa04360 | 1.33374617 |
| 31 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.32134952 |
| 32 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.28894156 |
| 33 | ECM-receptor interaction_Homo sapiens_hsa04512 | 1.27830124 |
| 34 | Cocaine addiction_Homo sapiens_hsa05030 | 1.27683939 |
| 35 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.25085665 |
| 36 | Gap junction_Homo sapiens_hsa04540 | 1.22417804 |
| 37 | Glioma_Homo sapiens_hsa05214 | 1.18347477 |
| 38 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.16927377 |
| 39 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.13993391 |
| 40 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.12724314 |
| 41 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.12691790 |
| 42 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.11716704 |
| 43 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.08486188 |
| 44 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.08406284 |
| 45 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.07417481 |
| 46 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.07224338 |
| 47 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.06814016 |
| 48 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.05893451 |
| 49 | Melanogenesis_Homo sapiens_hsa04916 | 1.05784164 |
| 50 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.03213118 |
| 51 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.02624727 |
| 52 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.01362915 |
| 53 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.98378674 |
| 54 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.97951950 |
| 55 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.96074024 |
| 56 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.95101691 |
| 57 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.93503405 |
| 58 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.92669956 |
| 59 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.92425355 |
| 60 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.81434539 |
| 61 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.80187431 |
| 62 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.78603963 |
| 63 | Endometrial cancer_Homo sapiens_hsa05213 | 0.76869256 |
| 64 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.76346033 |
| 65 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.75657224 |
| 66 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.74895879 |
| 67 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.74609172 |
| 68 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.74139054 |
| 69 | Lysine degradation_Homo sapiens_hsa00310 | 0.73509056 |
| 70 | Adherens junction_Homo sapiens_hsa04520 | 0.73464840 |
| 71 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.73296514 |
| 72 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.71193135 |
| 73 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.69914283 |
| 74 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.69909493 |
| 75 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.69693524 |
| 76 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.66645053 |
| 77 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.66297792 |
| 78 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.65134131 |
| 79 | Phototransduction_Homo sapiens_hsa04744 | 0.64683994 |
| 80 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.64501212 |
| 81 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.63885248 |
| 82 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.63874746 |
| 83 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.63024979 |
| 84 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.62533254 |
| 85 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.62062802 |
| 86 | Bile secretion_Homo sapiens_hsa04976 | 0.61645275 |
| 87 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.61607102 |
| 88 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.61470847 |
| 89 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.60597891 |
| 90 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.60103582 |
| 91 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.59676802 |
| 92 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.58500173 |
| 93 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.57781828 |
| 94 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.56885256 |
| 95 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.56056455 |
| 96 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.55932452 |
| 97 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.53858643 |
| 98 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.53251529 |
| 99 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.52614263 |
| 100 | Prion diseases_Homo sapiens_hsa05020 | 0.52495859 |
| 101 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.52092730 |
| 102 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.50187633 |
| 103 | Focal adhesion_Homo sapiens_hsa04510 | 0.48620281 |
| 104 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.48272808 |
| 105 | Tight junction_Homo sapiens_hsa04530 | 0.47948805 |
| 106 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.46937714 |
| 107 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.46333743 |
| 108 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.46003112 |
| 109 | Histidine metabolism_Homo sapiens_hsa00340 | 0.45707671 |
| 110 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.44910044 |
| 111 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.44731670 |
| 112 | Insulin resistance_Homo sapiens_hsa04931 | 0.42437762 |
| 113 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.41899952 |
| 114 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.41810328 |
| 115 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.41612461 |
| 116 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.41427076 |
| 117 | Melanoma_Homo sapiens_hsa05218 | 0.40883201 |
| 118 | Endocytosis_Homo sapiens_hsa04144 | 0.39433713 |
| 119 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.39368621 |
| 120 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.38258900 |
| 121 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.38164693 |
| 122 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.36853332 |
| 123 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.35108739 |
| 124 | Alzheimers disease_Homo sapiens_hsa05010 | 0.35074623 |

