DIRAS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DIRAS2 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.46842733
2locomotory exploration behavior (GO:0035641)6.41197962
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.36330464
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.95577025
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.95093567
6synaptic vesicle exocytosis (GO:0016079)5.73990782
7glutamate secretion (GO:0014047)5.54186429
8vocalization behavior (GO:0071625)5.43342506
9regulation of synaptic vesicle exocytosis (GO:2000300)5.32073019
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.30628409
11neuronal action potential propagation (GO:0019227)5.22736832
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.21537020
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.98155856
14regulation of glutamate receptor signaling pathway (GO:1900449)4.79891023
15regulation of synaptic vesicle transport (GO:1902803)4.74940370
16neurotransmitter secretion (GO:0007269)4.73059678
17cellular potassium ion homeostasis (GO:0030007)4.70133537
18exploration behavior (GO:0035640)4.68990549
19synaptic transmission, glutamatergic (GO:0035249)4.63993249
20glutamate receptor signaling pathway (GO:0007215)4.59518067
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.56099179
22protein localization to synapse (GO:0035418)4.53899709
23sodium ion export (GO:0071436)4.45441290
24regulation of neuronal synaptic plasticity (GO:0048168)4.43352153
25layer formation in cerebral cortex (GO:0021819)4.42169722
26gamma-aminobutyric acid transport (GO:0015812)4.40208525
27regulation of synapse structural plasticity (GO:0051823)4.34222728
28long-term memory (GO:0007616)4.32063487
29neuron-neuron synaptic transmission (GO:0007270)4.31066974
30potassium ion homeostasis (GO:0055075)4.21728851
31axon ensheathment in central nervous system (GO:0032291)4.20082942
32central nervous system myelination (GO:0022010)4.20082942
33cerebellar granule cell differentiation (GO:0021707)4.17356562
34postsynaptic membrane organization (GO:0001941)4.15938201
35cerebellar Purkinje cell differentiation (GO:0021702)4.12294545
36positive regulation of synapse maturation (GO:0090129)4.10373091
37neurotransmitter-gated ion channel clustering (GO:0072578)4.09067098
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.05625289
39amino acid import (GO:0043090)4.04956405
40regulation of excitatory postsynaptic membrane potential (GO:0060079)4.02391592
41G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.99793764
42dendritic spine morphogenesis (GO:0060997)3.97615286
43positive regulation of membrane potential (GO:0045838)3.96494706
44neuronal ion channel clustering (GO:0045161)3.89865593
45neuron cell-cell adhesion (GO:0007158)3.87102448
46gamma-aminobutyric acid signaling pathway (GO:0007214)3.81074222
47regulation of postsynaptic membrane potential (GO:0060078)3.81010891
48neurotransmitter transport (GO:0006836)3.78886881
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.75891192
50neuromuscular process controlling balance (GO:0050885)3.74787315
51synaptic vesicle endocytosis (GO:0048488)3.74616675
52proline transport (GO:0015824)3.74114915
53cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.71642621
54response to pheromone (GO:0019236)3.69525418
55regulation of synaptic plasticity (GO:0048167)3.66376480
56regulation of neurotransmitter secretion (GO:0046928)3.64717345
57negative regulation of dendrite morphogenesis (GO:0050774)3.60662423
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.58915503
59positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.58219958
60neurotransmitter uptake (GO:0001504)3.57759746
61long-term synaptic potentiation (GO:0060291)3.57163913
62activation of protein kinase A activity (GO:0034199)3.55984372
63regulation of dendritic spine morphogenesis (GO:0061001)3.55680324
64neuromuscular process controlling posture (GO:0050884)3.54273574
65regulation of neurotransmitter levels (GO:0001505)3.52566998
66transmission of nerve impulse (GO:0019226)3.45161613
67positive regulation of dendritic spine morphogenesis (GO:0061003)3.43541310
68cell communication by electrical coupling (GO:0010644)3.41521787
69prepulse inhibition (GO:0060134)3.41042840
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.39030901
71regulation of neurotransmitter transport (GO:0051588)3.37689584
72regulation of voltage-gated calcium channel activity (GO:1901385)3.34162726
73neuromuscular synaptic transmission (GO:0007274)3.33893440
74negative regulation of synaptic transmission, GABAergic (GO:0032229)3.33870100
75regulation of ARF protein signal transduction (GO:0032012)3.33282878
76regulation of vesicle fusion (GO:0031338)3.32216820
77serotonin metabolic process (GO:0042428)3.32161357
78membrane depolarization during action potential (GO:0086010)3.32131332
79membrane depolarization (GO:0051899)3.31001020
80glycine transport (GO:0015816)3.28780803
81regulation of dendritic spine development (GO:0060998)3.28285214
82long term synaptic depression (GO:0060292)3.28211766
83auditory behavior (GO:0031223)3.27879012
84presynaptic membrane organization (GO:0097090)3.26602704
85regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.26407151
86membrane hyperpolarization (GO:0060081)3.26351908
87acidic amino acid transport (GO:0015800)3.25849792
88dendrite morphogenesis (GO:0048813)3.25433796
89positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.23746911
90synaptic vesicle transport (GO:0048489)3.22303434
91establishment of synaptic vesicle localization (GO:0097480)3.22303434
92cell differentiation in hindbrain (GO:0021533)3.21110358
93positive regulation of neurotransmitter secretion (GO:0001956)3.20585995
94chemosensory behavior (GO:0007635)3.19684919
95innervation (GO:0060384)3.18283375
96presynaptic membrane assembly (GO:0097105)3.17873410
97potassium ion import (GO:0010107)3.12733504
98positive regulation of neurotransmitter transport (GO:0051590)3.12471768
99adult walking behavior (GO:0007628)3.11083800
100regulation of synapse maturation (GO:0090128)3.10864097
101cellular sodium ion homeostasis (GO:0006883)3.10753695
102detection of calcium ion (GO:0005513)3.08802844
103response to auditory stimulus (GO:0010996)3.08642583
104neuromuscular process (GO:0050905)3.08628405
105neuron recognition (GO:0008038)3.07899496
106L-amino acid import (GO:0043092)3.07521666
107vesicle docking involved in exocytosis (GO:0006904)3.06882228
108positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.05728429
109cell communication involved in cardiac conduction (GO:0086065)3.05007938
110regulation of synaptic transmission (GO:0050804)3.04241523
111behavioral defense response (GO:0002209)3.03105535
112behavioral fear response (GO:0001662)3.03105535
113primary amino compound metabolic process (GO:1901160)3.03034718
114synaptic transmission (GO:0007268)3.03029922
115learning (GO:0007612)3.02471250
116regulation of clathrin-mediated endocytosis (GO:2000369)3.02015675
117synapse assembly (GO:0007416)3.01643315
118vesicle transport along microtubule (GO:0047496)3.01538039
119signal release (GO:0023061)3.00530400
120positive regulation of synaptic transmission (GO:0050806)3.00359773
121positive regulation of dendritic spine development (GO:0060999)2.98835608
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.98601297

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.04029859
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.15065833
3GBX2_23144817_ChIP-Seq_PC3_Human3.14580448
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08611865
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05021477
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.83003438
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.83003438
8DROSHA_22980978_ChIP-Seq_HELA_Human2.82672175
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.82418071
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.78783176
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63473557
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59065920
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56272957
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55360524
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48024732
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.43262204
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39510554
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.33037139
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.32019310
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.31228937
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26063880
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.25295600
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.23151649
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.16871289
25* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16763909
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95605003
27AR_21572438_ChIP-Seq_LNCaP_Human1.82997045
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.82526003
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80650796
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73680726
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71372291
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.66887740
33SMAD4_21799915_ChIP-Seq_A2780_Human1.59515754
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54435497
35* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37660470
36ZNF274_21170338_ChIP-Seq_K562_Hela1.36397058
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36132462
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.35268467
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33920677
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.30692610
41AR_19668381_ChIP-Seq_PC3_Human1.30528605
42KDM2B_26808549_Chip-Seq_K562_Human1.30392502
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30346354
44SOX2_21211035_ChIP-Seq_LN229_Gbm1.28206514
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27877952
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25929696
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25716279
48STAT3_23295773_ChIP-Seq_U87_Human1.21147162
49* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20902365
50TAF15_26573619_Chip-Seq_HEK293_Human1.20419766
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17498974
52* AR_25329375_ChIP-Seq_VCAP_Human1.17177109
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17059985
54EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16777547
55GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16388181
56* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14800813
57P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14226512
58RING1B_27294783_Chip-Seq_NPCs_Mouse1.12818405
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12267154
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.12010648
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10734611
62* P300_19829295_ChIP-Seq_ESCs_Human1.10361375
63TP53_16413492_ChIP-PET_HCT116_Human1.06379458
64ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05843341
65* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05518232
66RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04445387
67* TCF4_23295773_ChIP-Seq_U87_Human1.04365894
68* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03737076
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02588289
70* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02134898
71* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01593537
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01224190
73ARNT_22903824_ChIP-Seq_MCF-7_Human0.99697345
74SMAD3_21741376_ChIP-Seq_ESCs_Human0.98527731
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98473750
76CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98437661
77CTCF_27219007_Chip-Seq_Bcells_Human0.97807128
78* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97413657
79PIAS1_25552417_ChIP-Seq_VCAP_Human0.97320960
80* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97253790
81SMAD3_21741376_ChIP-Seq_HESCs_Human0.96058869
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95368833
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94663415
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94641072
85SMAD4_21741376_ChIP-Seq_HESCs_Human0.94413402
86TET1_21490601_ChIP-Seq_MESCs_Mouse0.94014196
87CBX2_27304074_Chip-Seq_ESCs_Mouse0.93644911
88OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93190354
89AHR_22903824_ChIP-Seq_MCF-7_Human0.92973307
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92694522
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92690241
92ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91239931
93* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89865698
94* RUNX2_22187159_ChIP-Seq_PCA_Human0.87059288
95RNF2_27304074_Chip-Seq_NSC_Mouse0.86440031
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85167106
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85167106
98CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85148906
99BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85141163
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84948018
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84550717
102DPY_21335234_ChIP-Seq_ESCs_Mouse0.84453823
103* RXR_22108803_ChIP-Seq_LS180_Human0.84315763
104* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84172973
105FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83969572
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83776089
107* PRDM14_20953172_ChIP-Seq_ESCs_Human0.83716669
108OCT4_19829295_ChIP-Seq_ESCs_Human0.83337347
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83192740
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82897231
111LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82674709
112SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.80947888
113PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78371858
114KDM2B_26808549_Chip-Seq_REH_Human0.76344178
115* GATA1_26923725_Chip-Seq_HPCs_Mouse0.75248453

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.11740823
2MP0003635_abnormal_synaptic_transmissio4.43987374
3MP0003880_abnormal_central_pattern4.27664384
4MP0004270_analgesia3.84094664
5MP0009046_muscle_twitch3.78325682
6MP0009745_abnormal_behavioral_response3.52139832
7MP0002063_abnormal_learning/memory/cond3.44911272
8MP0002064_seizures3.31799315
9MP0001968_abnormal_touch/_nociception3.02513787
10MP0002572_abnormal_emotion/affect_behav2.88989206
11MP0005423_abnormal_somatic_nervous2.86724323
12MP0002272_abnormal_nervous_system2.83773570
13MP0002734_abnormal_mechanical_nocicepti2.76320675
14MP0001486_abnormal_startle_reflex2.64197601
15MP0002822_catalepsy2.62203171
16MP0008569_lethality_at_weaning2.53114475
17MP0001501_abnormal_sleep_pattern2.37639030
18MP0002736_abnormal_nociception_after2.28231127
19MP0001440_abnormal_grooming_behavior2.20939234
20MP0002067_abnormal_sensory_capabilities2.14285165
21MP0002735_abnormal_chemical_nociception2.07636114
22MP0002184_abnormal_innervation1.95553971
23MP0002733_abnormal_thermal_nociception1.94713099
24MP0001970_abnormal_pain_threshold1.91991035
25MP0003329_amyloid_beta_deposits1.90402799
26MP0004924_abnormal_behavior1.84847544
27MP0005386_behavior/neurological_phenoty1.84847544
28MP0004811_abnormal_neuron_physiology1.81104568
29MP0002909_abnormal_adrenal_gland1.80467501
30MP0002557_abnormal_social/conspecific_i1.77897188
31MP0009780_abnormal_chondrocyte_physiolo1.73507039
32MP0003879_abnormal_hair_cell1.69494471
33MP0004858_abnormal_nervous_system1.67199554
34MP0000778_abnormal_nervous_system1.57960881
35MP0004885_abnormal_endolymph1.56233521
36MP0000955_abnormal_spinal_cord1.55965106
37MP0004145_abnormal_muscle_electrophysio1.50973673
38MP0001984_abnormal_olfaction1.50950296
39MP0002066_abnormal_motor_capabilities/c1.49916994
40MP0004147_increased_porphyrin_level1.47514781
41MP0002882_abnormal_neuron_morphology1.44654698
42MP0003633_abnormal_nervous_system1.44553233
43MP0005646_abnormal_pituitary_gland1.40369021
44MP0003123_paternal_imprinting1.38573935
45MP0001502_abnormal_circadian_rhythm1.38102274
46MP0004142_abnormal_muscle_tone1.27165588
47MP0003631_nervous_system_phenotype1.26787557
48MP0005551_abnormal_eye_electrophysiolog1.26400222
49MP0000569_abnormal_digit_pigmentation1.21726338
50MP0003787_abnormal_imprinting1.18760942
51MP0008872_abnormal_physiological_respon1.15313626
52MP0002152_abnormal_brain_morphology1.13959562
53MP0006276_abnormal_autonomic_nervous1.08131066
54MP0008877_abnormal_DNA_methylation1.06971728
55MP0002229_neurodegeneration1.06010595
56MP0003632_abnormal_nervous_system1.04767627
57MP0004742_abnormal_vestibular_system1.03038247
58MP0001986_abnormal_taste_sensitivity1.02138865
59MP0001348_abnormal_lacrimal_gland1.00597551
60MP0008874_decreased_physiological_sensi0.98544449
61MP0001905_abnormal_dopamine_level0.97236026
62MP0005645_abnormal_hypothalamus_physiol0.96930846
63MP0003075_altered_response_to0.96866781
64MP0002069_abnormal_eating/drinking_beha0.92514634
65MP0003690_abnormal_glial_cell0.90585599
66MP0008961_abnormal_basal_metabolism0.90151802
67MP0001177_atelectasis0.89742277
68MP0002090_abnormal_vision0.88451615
69MP0001529_abnormal_vocalization0.85872725
70MP0000604_amyloidosis0.84915136
71MP0000920_abnormal_myelination0.84488334
72MP0000751_myopathy0.84462679
73MP0004510_myositis0.83129580
74MP0001188_hyperpigmentation0.83026036
75MP0004215_abnormal_myocardial_fiber0.82471319
76MP0004085_abnormal_heartbeat0.80952705
77MP0000013_abnormal_adipose_tissue0.80362131
78MP0005535_abnormal_body_temperature0.79441514
79MP0003634_abnormal_glial_cell0.77540161
80MP0004233_abnormal_muscle_weight0.76814727
81MP0003283_abnormal_digestive_organ0.76807359
82MP0001963_abnormal_hearing_physiology0.76712760
83MP0004484_altered_response_of0.75973113
84MP0005394_taste/olfaction_phenotype0.73950725
85MP0005499_abnormal_olfactory_system0.73950725
86MP0010386_abnormal_urinary_bladder0.73187707
87MP0002752_abnormal_somatic_nervous0.72763135
88MP0001346_abnormal_lacrimal_gland0.71079407
89MP0010234_abnormal_vibrissa_follicle0.69075929
90MP0003121_genomic_imprinting0.66896085
91MP0003137_abnormal_impulse_conducting0.65907247
92MP0003122_maternal_imprinting0.65490994
93MP0005167_abnormal_blood-brain_barrier0.65179843
94MP0006072_abnormal_retinal_apoptosis0.64644348
95MP0002638_abnormal_pupillary_reflex0.64249703
96MP0004043_abnormal_pH_regulation0.62368624
97MP0000631_abnormal_neuroendocrine_gland0.61039348
98MP0004130_abnormal_muscle_cell0.60976151
99MP0005187_abnormal_penis_morphology0.59197648
100MP0001485_abnormal_pinna_reflex0.57268442
101MP0010769_abnormal_survival0.57039022
102MP0003172_abnormal_lysosome_physiology0.55609871
103MP0001299_abnormal_eye_distance/0.54608638
104MP0010768_mortality/aging0.53656379
105MP0002082_postnatal_lethality0.52691935
106MP0010770_preweaning_lethality0.52691935
107MP0003861_abnormal_nervous_system0.52551254
108MP0005623_abnormal_meninges_morphology0.52231738
109MP0000026_abnormal_inner_ear0.51261462
110MP0000579_abnormal_nail_morphology0.50812716
111MP0003956_abnormal_body_size0.49430443
112MP0001943_abnormal_respiration0.46217393
113MP0001765_abnormal_ion_homeostasis0.42646824

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.46838656
2Myokymia (HP:0002411)7.12372564
3Focal seizures (HP:0007359)5.92493445
4Visual hallucinations (HP:0002367)5.87470064
5Progressive cerebellar ataxia (HP:0002073)5.38077584
6Action tremor (HP:0002345)5.37788570
7Epileptic encephalopathy (HP:0200134)4.83563314
8Febrile seizures (HP:0002373)4.62466949
9Atonic seizures (HP:0010819)4.61552853
10Gaze-evoked nystagmus (HP:0000640)4.40602583
11Absence seizures (HP:0002121)4.26439391
12Broad-based gait (HP:0002136)3.98237018
13Dysdiadochokinesis (HP:0002075)3.95079930
14Generalized tonic-clonic seizures (HP:0002069)3.85006743
15Dialeptic seizures (HP:0011146)3.79840655
16Poor eye contact (HP:0000817)3.76053514
17Impaired smooth pursuit (HP:0007772)3.62733161
18Cerebral hypomyelination (HP:0006808)3.59696225
19Scanning speech (HP:0002168)3.53609619
20Dysmetria (HP:0001310)3.52785211
21Dysmetric saccades (HP:0000641)3.51340244
22Genetic anticipation (HP:0003743)3.44626198
23Depression (HP:0000716)3.42281715
24Supranuclear gaze palsy (HP:0000605)3.38252525
25Truncal ataxia (HP:0002078)3.36952361
26Impaired social interactions (HP:0000735)3.35149495
27Abnormal social behavior (HP:0012433)3.35149495
28Impaired vibration sensation in the lower limbs (HP:0002166)3.29351927
29Abnormality of ocular smooth pursuit (HP:0000617)3.27043581
30Intention tremor (HP:0002080)3.26971254
31Abnormality of the lower motor neuron (HP:0002366)3.25112940
32Ankle clonus (HP:0011448)3.15389323
33Hemiplegia (HP:0002301)3.14379113
34Postural instability (HP:0002172)3.11906106
35Mutism (HP:0002300)3.08687902
36Anxiety (HP:0000739)3.07125782
37Urinary bladder sphincter dysfunction (HP:0002839)3.03513335
38Papilledema (HP:0001085)3.03417826
39Abnormality of binocular vision (HP:0011514)2.95554180
40Diplopia (HP:0000651)2.95554180
41Hemiparesis (HP:0001269)2.93425005
42Annular pancreas (HP:0001734)2.84269714
43Abnormal eating behavior (HP:0100738)2.82068382
44Hyperventilation (HP:0002883)2.80249376
45Akinesia (HP:0002304)2.78444309
46Ventricular fibrillation (HP:0001663)2.77506165
47Sleep apnea (HP:0010535)2.71141309
48Status epilepticus (HP:0002133)2.67117265
49Amblyopia (HP:0000646)2.65530682
50Stereotypic behavior (HP:0000733)2.65119044
51Delusions (HP:0000746)2.64263163
52Torticollis (HP:0000473)2.57050349
53Urinary urgency (HP:0000012)2.53963108
54Spastic gait (HP:0002064)2.53465523
55Spastic tetraparesis (HP:0001285)2.48887012
56Excessive salivation (HP:0003781)2.47791997
57Drooling (HP:0002307)2.47791997
58Focal dystonia (HP:0004373)2.46353644
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.45027387
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.45027387
61Bradykinesia (HP:0002067)2.44621359
62Morphological abnormality of the pyramidal tract (HP:0002062)2.44269049
63Polyphagia (HP:0002591)2.40907941
64CNS hypomyelination (HP:0003429)2.38461998
65Fetal akinesia sequence (HP:0001989)2.35144318
66Epileptiform EEG discharges (HP:0011182)2.34399217
67Impaired vibratory sensation (HP:0002495)2.33567144
68Pointed chin (HP:0000307)2.33115831
69Megalencephaly (HP:0001355)2.32105696
70Choreoathetosis (HP:0001266)2.29764389
71EEG with generalized epileptiform discharges (HP:0011198)2.28057601
72Abnormality of saccadic eye movements (HP:0000570)2.27770836
73Absent speech (HP:0001344)2.26040801
74Bundle branch block (HP:0011710)2.25588245
75Progressive inability to walk (HP:0002505)2.23800803
76Amyotrophic lateral sclerosis (HP:0007354)2.22153212
77Gait ataxia (HP:0002066)2.21738200
78Abnormality of the corticospinal tract (HP:0002492)2.21631856
79Tetraplegia (HP:0002445)2.21582356
80Neurofibrillary tangles (HP:0002185)2.20166868
81Cerebral inclusion bodies (HP:0100314)2.17527196
82Hypsarrhythmia (HP:0002521)2.14753324
83Apathy (HP:0000741)2.14461772
84Agitation (HP:0000713)2.12633377
85Lower limb asymmetry (HP:0100559)2.11917492
86Postural tremor (HP:0002174)2.09422561
87Craniofacial dystonia (HP:0012179)2.08941708
88Generalized myoclonic seizures (HP:0002123)2.07275663
89Incomplete penetrance (HP:0003829)2.06547649
90Horizontal nystagmus (HP:0000666)2.06327687
91Peripheral hypomyelination (HP:0007182)2.05897001
92Insidious onset (HP:0003587)2.04618762
93Termporal pattern (HP:0011008)2.04618762
94Neuronal loss in central nervous system (HP:0002529)2.03520767
95Limb ataxia (HP:0002070)2.00609032
96Obstructive sleep apnea (HP:0002870)2.00133094
97Rapidly progressive (HP:0003678)1.97487066
98Increased circulating renin level (HP:0000848)1.95762307
99Insomnia (HP:0100785)1.95583155
100Diminished motivation (HP:0000745)1.94889841
101Clonus (HP:0002169)1.93815385
102Inappropriate behavior (HP:0000719)1.90339815
103Lower limb muscle weakness (HP:0007340)1.89697646
104Pheochromocytoma (HP:0002666)1.85402363
105Limb dystonia (HP:0002451)1.84907704
106Central scotoma (HP:0000603)1.82913766
107Spastic tetraplegia (HP:0002510)1.82815797
108Rigidity (HP:0002063)1.81807654
109Spinal canal stenosis (HP:0003416)1.80253980
110Psychosis (HP:0000709)1.79985043
111Unsteady gait (HP:0002317)1.79843123
112Inability to walk (HP:0002540)1.79260347
113Memory impairment (HP:0002354)1.78207834
114Resting tremor (HP:0002322)1.76642218
115Prolonged QT interval (HP:0001657)1.74165136
116Abnormal EKG (HP:0003115)1.71572809
117Heart block (HP:0012722)1.70935776
118Paraplegia (HP:0010550)1.70772817
119Intellectual disability, profound (HP:0002187)1.70619049
120Abnormality of the periventricular white matter (HP:0002518)1.66909038
121Aqueductal stenosis (HP:0002410)1.66661368
122Blue irides (HP:0000635)1.65315025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.19360889
2MAP3K94.14922064
3EPHA43.94552099
4MAP3K43.09418500
5DAPK22.74247367
6MARK12.69431789
7MINK12.69008427
8PAK62.53977416
9MAP2K72.43010858
10CAMKK12.40037448
11KSR22.27452167
12RIPK42.20098232
13PRKD32.11424153
14CAMKK22.03781908
15NTRK22.03325793
16MAP2K42.00317310
17CDK191.79060725
18STK381.78756755
19KSR11.64418737
20NTRK11.63018732
21DAPK11.55816063
22CDK51.53134334
23MAP3K121.52371721
24PRPF4B1.48836976
25RIPK11.45373627
26MAP3K131.39109645
27GRK51.30041398
28SIK21.29103155
29PLK21.28386131
30ARAF1.27255911
31TYRO31.26201401
32PRKCG1.24292967
33TNIK1.19308770
34PNCK1.18665344
35TAOK11.13119585
36CAMK11.12941619
37MAP3K21.12529136
38FES1.08147941
39MAPK131.06727301
40STK111.04545509
41PINK11.04246386
42UHMK11.03633107
43BMPR20.98941781
44SGK2230.98615169
45SGK4940.98615169
46CDK180.98058382
47CDK150.97928292
48RET0.96301366
49PRKCH0.95991913
50SGK20.90942826
51CAMK2A0.90849750
52LATS20.90451510
53CDK140.89652149
54ALK0.89109359
55RAF10.88560952
56SGK30.86705181
57CASK0.86269223
58CDK11A0.85413536
59PDK10.83991680
60WNK10.82946351
61PHKG20.80954550
62PHKG10.80954550
63OXSR10.80806060
64PKN10.74376577
65DYRK1A0.73795424
66PTK2B0.72951976
67SGK10.72917360
68FGFR20.71057854
69CAMK2B0.70265608
70PDPK10.70158944
71LIMK10.65742929
72MARK20.63398492
73PAK30.62765972
74CAMK40.62521201
75WNK40.59766982
76NEK10.57421447
77MAP3K10.56220734
78CAMK1G0.55937658
79LMTK20.54668477
80MAP3K110.53807874
81RPS6KA30.53333177
82CSNK1G20.52814621
83CDC42BPA0.51225346
84MAP3K60.50946209
85CAMK2G0.50087675
86SCYL20.49767089
87BRAF0.48933105
88STK390.48625727
89FYN0.47308180
90MAP3K70.46853067
91TNK20.46747101
92PRKCZ0.46532599
93CAMK2D0.45290329
94NEK60.43939643
95MAPK100.42676185
96MAPKAPK50.39301174
97PRKCA0.38381545
98DMPK0.38373582
99BRSK10.36822703
100DAPK30.35591329
101MOS0.34046874
102ROCK20.34002845
103MAPK120.32802187
104PRKCE0.32577508
105MAP2K10.31791793
106CCNB10.31298188
107PRKCB0.31175238
108PRKACA0.30038907
109PRKG10.28297927
110ERBB20.27722521
111CSNK1D0.27536591
112MAP2K60.24953478

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.73003010
2Synaptic vesicle cycle_Homo sapiens_hsa047213.21024137
3Long-term potentiation_Homo sapiens_hsa047202.84101833
4Glutamatergic synapse_Homo sapiens_hsa047242.76178608
5Circadian entrainment_Homo sapiens_hsa047132.75775165
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72116204
7GABAergic synapse_Homo sapiens_hsa047272.65404485
8Olfactory transduction_Homo sapiens_hsa047402.64547655
9Morphine addiction_Homo sapiens_hsa050322.48707113
10Amphetamine addiction_Homo sapiens_hsa050312.42769057
11Salivary secretion_Homo sapiens_hsa049702.28463683
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26191136
13Dopaminergic synapse_Homo sapiens_hsa047282.11159161
14Insulin secretion_Homo sapiens_hsa049111.99139526
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.98090955
16Gastric acid secretion_Homo sapiens_hsa049711.97899666
17Long-term depression_Homo sapiens_hsa047301.96406508
18Cholinergic synapse_Homo sapiens_hsa047251.92253572
19Taste transduction_Homo sapiens_hsa047421.74810451
20Oxytocin signaling pathway_Homo sapiens_hsa049211.70844778
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70066402
22Renin secretion_Homo sapiens_hsa049241.62762834
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.56774807
24Calcium signaling pathway_Homo sapiens_hsa040201.55403325
25Serotonergic synapse_Homo sapiens_hsa047261.51390899
26GnRH signaling pathway_Homo sapiens_hsa049121.50244488
27Cocaine addiction_Homo sapiens_hsa050301.47853498
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46440446
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.35407676
30Gap junction_Homo sapiens_hsa045401.34346902
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34298233
32cAMP signaling pathway_Homo sapiens_hsa040241.30557371
33Type II diabetes mellitus_Homo sapiens_hsa049301.29849010
34Nitrogen metabolism_Homo sapiens_hsa009101.27599714
35Vitamin B6 metabolism_Homo sapiens_hsa007501.25738545
36Estrogen signaling pathway_Homo sapiens_hsa049151.21124310
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20002120
38Glioma_Homo sapiens_hsa052141.14069860
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12255731
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10351020
41Phototransduction_Homo sapiens_hsa047441.05469091
42Collecting duct acid secretion_Homo sapiens_hsa049661.02842784
43Pancreatic secretion_Homo sapiens_hsa049721.00599534
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00562207
45ErbB signaling pathway_Homo sapiens_hsa040120.98245276
46Melanogenesis_Homo sapiens_hsa049160.96393858
47Oocyte meiosis_Homo sapiens_hsa041140.95853235
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.91783536
49Thyroid hormone synthesis_Homo sapiens_hsa049180.91691788
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.91581769
51Axon guidance_Homo sapiens_hsa043600.85244037
52Cardiac muscle contraction_Homo sapiens_hsa042600.84976063
53Dorso-ventral axis formation_Homo sapiens_hsa043200.84213335
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80551115
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79896759
56Choline metabolism in cancer_Homo sapiens_hsa052310.78535189
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75249982
58VEGF signaling pathway_Homo sapiens_hsa043700.71385035
59MAPK signaling pathway_Homo sapiens_hsa040100.71236488
60Dilated cardiomyopathy_Homo sapiens_hsa054140.70815511
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70071263
62mTOR signaling pathway_Homo sapiens_hsa041500.67647287
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.67043464
64Circadian rhythm_Homo sapiens_hsa047100.66152796
65Inositol phosphate metabolism_Homo sapiens_hsa005620.65449096
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62805002
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59173226
68Bile secretion_Homo sapiens_hsa049760.57810582
69Vibrio cholerae infection_Homo sapiens_hsa051100.56832316
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.56475189
71Glucagon signaling pathway_Homo sapiens_hsa049220.56367877
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55928289
73Rap1 signaling pathway_Homo sapiens_hsa040150.53422975
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51839967
75Non-small cell lung cancer_Homo sapiens_hsa052230.51367735
76Ras signaling pathway_Homo sapiens_hsa040140.50439286
77Endocytosis_Homo sapiens_hsa041440.50405522
78Fatty acid biosynthesis_Homo sapiens_hsa000610.47277833
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46340793
80Mineral absorption_Homo sapiens_hsa049780.46078420
81Alcoholism_Homo sapiens_hsa050340.44971448
82Endometrial cancer_Homo sapiens_hsa052130.44563859
83Alzheimers disease_Homo sapiens_hsa050100.44463082
84Arginine and proline metabolism_Homo sapiens_hsa003300.43364858
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42109386
86African trypanosomiasis_Homo sapiens_hsa051430.40686632
87Histidine metabolism_Homo sapiens_hsa003400.40607917
88Chemokine signaling pathway_Homo sapiens_hsa040620.40280650
89Renal cell carcinoma_Homo sapiens_hsa052110.39354011
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39276976
91Arginine biosynthesis_Homo sapiens_hsa002200.38749423
92Ovarian steroidogenesis_Homo sapiens_hsa049130.35888339
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35632559
94Wnt signaling pathway_Homo sapiens_hsa043100.35292718
95Insulin signaling pathway_Homo sapiens_hsa049100.34337563
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34118558
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33612945
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33414155
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33176667
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32947919
101Type I diabetes mellitus_Homo sapiens_hsa049400.30711115
102Platelet activation_Homo sapiens_hsa046110.29709411
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28795187
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28349722
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28147546
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27641760
107Prion diseases_Homo sapiens_hsa050200.26441675
108beta-Alanine metabolism_Homo sapiens_hsa004100.25447357
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24502983
110Ether lipid metabolism_Homo sapiens_hsa005650.24135028
111Regulation of autophagy_Homo sapiens_hsa041400.22485224
112Butanoate metabolism_Homo sapiens_hsa006500.18570242
113ABC transporters_Homo sapiens_hsa020100.16962748
114AMPK signaling pathway_Homo sapiens_hsa041520.13940417
115Tight junction_Homo sapiens_hsa045300.13131818

Most similar genes based on co-expression Upload to Enrichr

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