DIRAS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ras superfamily. This gene is imprinted gene with monoallelic expression of the paternal allele which is associated with growth suppression. The encoded protein acts as a tumor suppressor whose function is abrogated in many ovarian and breast cancers. This protein may also play a role autophagy in certain cancer cells by regulating the autophagosome initiation complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1embryonic retina morphogenesis in camera-type eye (GO:0060059)5.60847121
2positive regulation of gastrulation (GO:2000543)5.25040880
3pyrimidine nucleobase catabolic process (GO:0006208)5.07103618
4head development (GO:0060322)4.89158970
5ionotropic glutamate receptor signaling pathway (GO:0035235)4.37268227
6nucleobase catabolic process (GO:0046113)4.35820974
7regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.35541711
8regulation of cAMP-dependent protein kinase activity (GO:2000479)4.27868532
9presynaptic membrane assembly (GO:0097105)4.27583427
10positive regulation of amino acid transport (GO:0051957)4.21779552
11negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.20743383
12positive regulation of synaptic transmission, GABAergic (GO:0032230)4.18434989
13presynaptic membrane organization (GO:0097090)4.05904439
14primitive streak formation (GO:0090009)3.98865579
15postsynaptic membrane organization (GO:0001941)3.70131938
16establishment of mitochondrion localization (GO:0051654)3.61526484
17startle response (GO:0001964)3.58941993
18glutamate receptor signaling pathway (GO:0007215)3.58916494
19glomerulus development (GO:0032835)3.58393980
20glycosphingolipid biosynthetic process (GO:0006688)3.56572831
21secondary heart field specification (GO:0003139)3.53661529
22heart field specification (GO:0003128)3.53661529
23synaptic transmission, glutamatergic (GO:0035249)3.51663103
24somite rostral/caudal axis specification (GO:0032525)3.49709067
25neuron recognition (GO:0008038)3.48753729
26axonal fasciculation (GO:0007413)3.44028763
27apical protein localization (GO:0045176)3.41758332
28nonmotile primary cilium assembly (GO:0035058)3.40270800
29cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.36483544
30neurofilament cytoskeleton organization (GO:0060052)3.29226208
31retinal ganglion cell axon guidance (GO:0031290)3.24021436
32spinal cord association neuron differentiation (GO:0021527)3.16074710
33ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.09068647
34neuron-neuron synaptic transmission (GO:0007270)3.06133327
35retina layer formation (GO:0010842)3.02382842
36neuron cell-cell adhesion (GO:0007158)3.01830188
37mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.99296580
38positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.99296580
39response to pheromone (GO:0019236)2.99211631
40negative regulation of axon extension (GO:0030517)2.95737449
41axon extension (GO:0048675)2.94440367
42positive regulation of mitochondrial fission (GO:0090141)2.93797378
43regulation of short-term neuronal synaptic plasticity (GO:0048172)2.86412423
44adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.86321118
45glycerophospholipid catabolic process (GO:0046475)2.82254915
46endoderm formation (GO:0001706)2.82128311
47embryonic viscerocranium morphogenesis (GO:0048703)2.81594995
48response to follicle-stimulating hormone (GO:0032354)2.80499041
49motor neuron axon guidance (GO:0008045)2.79869112
50cellular ketone body metabolic process (GO:0046950)2.79711018
51regulation of meiosis I (GO:0060631)2.78357421
52regulation of synaptic transmission, GABAergic (GO:0032228)2.76096852
53regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.75596606
54cochlea development (GO:0090102)2.75457883
55asymmetric protein localization (GO:0008105)2.72174248
56cellular response to gonadotropin stimulus (GO:0071371)2.71382074
57synaptic vesicle maturation (GO:0016188)2.70275926
58regulation of synaptic vesicle exocytosis (GO:2000300)2.70259174
59positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.69931010
60cerebellar Purkinje cell differentiation (GO:0021702)2.68195072
61negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66835838
62behavioral response to nicotine (GO:0035095)2.64072979
63urogenital system development (GO:0001655)2.63081632
64negative regulation of axon extension involved in axon guidance (GO:0048843)2.62768634
65specification of organ identity (GO:0010092)2.62305694
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.62210503
67protein localization to synapse (GO:0035418)2.61049984
68uterus development (GO:0060065)2.60744135
69inositol phosphate catabolic process (GO:0071545)2.60109073
70regulation of male gonad development (GO:2000018)2.59377672
71membrane hyperpolarization (GO:0060081)2.57305825
72membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.56682593
73positive regulation of synapse assembly (GO:0051965)2.56281181
74regulation of axon extension involved in axon guidance (GO:0048841)2.55564135
75regulation of excitatory postsynaptic membrane potential (GO:0060079)2.53995163
76establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.53682340
77mitochondrion transport along microtubule (GO:0047497)2.53682340
78dendrite morphogenesis (GO:0048813)2.53341424
79response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.51947520
80regulation of postsynaptic membrane potential (GO:0060078)2.51344048
81DNA double-strand break processing (GO:0000729)2.49161185
82neuron projection extension (GO:1990138)2.49126288
83dendritic spine morphogenesis (GO:0060997)2.46529261
84positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.46026734
85positive regulation of amine transport (GO:0051954)2.45774634
86organelle transport along microtubule (GO:0072384)2.44830847
87regulation of axon guidance (GO:1902667)2.43866266
88negative regulation of axon guidance (GO:1902668)2.43380200
89ketone body metabolic process (GO:1902224)2.42811871
90regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.41584211
91protein K48-linked ubiquitination (GO:0070936)2.40889004
92positive regulation of mesonephros development (GO:0061213)2.40565812
93positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.40445760
94cerebellum development (GO:0021549)2.40068603
95regulation of respiratory system process (GO:0044065)2.39682914
96neurotransmitter-gated ion channel clustering (GO:0072578)2.38772717
97kidney morphogenesis (GO:0060993)2.37097525
98regulation of membrane repolarization (GO:0060306)2.36911626
99cardiac ventricle formation (GO:0003211)2.36720052
100protein K6-linked ubiquitination (GO:0085020)2.35976418

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.94373636
2GBX2_23144817_ChIP-Seq_PC3_Human3.85056483
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.32029447
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.25074962
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.87146355
6IGF1R_20145208_ChIP-Seq_DFB_Human2.61243673
7TAF15_26573619_Chip-Seq_HEK293_Human2.58823912
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.57296708
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.56437430
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.29359250
11* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25145283
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.22558659
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21589379
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06761137
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.03950983
16PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.96490620
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93844987
18FUS_26573619_Chip-Seq_HEK293_Human1.93602589
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.90760914
20ZNF274_21170338_ChIP-Seq_K562_Hela1.89675701
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.89063113
22* P300_19829295_ChIP-Seq_ESCs_Human1.87424954
23SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.86585650
24RNF2_27304074_Chip-Seq_NSC_Mouse1.83992986
25REST_21632747_ChIP-Seq_MESCs_Mouse1.82308787
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81774747
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.78797789
28* SMAD4_21799915_ChIP-Seq_A2780_Human1.78287602
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73588728
30OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73232590
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65734018
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.65623514
33EWS_26573619_Chip-Seq_HEK293_Human1.64235927
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63004873
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.61307236
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59697070
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58892027
38* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55597562
39AR_25329375_ChIP-Seq_VCAP_Human1.54676441
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52981559
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.49397467
42STAT3_23295773_ChIP-Seq_U87_Human1.48920419
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48466320
44ER_23166858_ChIP-Seq_MCF-7_Human1.47836228
45TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47788998
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46781231
47VDR_22108803_ChIP-Seq_LS180_Human1.44639691
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.43969736
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43528184
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.43470099
51SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.42381994
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42222275
53CBP_20019798_ChIP-Seq_JUKART_Human1.41715519
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41715519
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41023335
56RUNX2_22187159_ChIP-Seq_PCA_Human1.38455646
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36649290
58HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36517413
59* SMAD3_21741376_ChIP-Seq_EPCs_Human1.35722366
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34870172
61EZH2_18974828_ChIP-Seq_MESCs_Mouse1.34830509
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.34830509
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34565520
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33825195
65TCF4_23295773_ChIP-Seq_U87_Human1.32185004
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30301265
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.29811333
68LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27648881
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.25002165
70TAL1_26923725_Chip-Seq_HPCs_Mouse1.24592557
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22157933
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.21352405
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.20393915
74STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17021197
75TP53_18474530_ChIP-ChIP_U2OS_Human1.16394745
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16237149
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16237149
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15631298
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13425895
80BCAT_22108803_ChIP-Seq_LS180_Human1.12253745
81WT1_19549856_ChIP-ChIP_CCG9911_Human1.11079270
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10471319
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10423226
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09504432
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08286253
86EP300_21415370_ChIP-Seq_HL-1_Mouse1.06883024
87JUN_21703547_ChIP-Seq_K562_Human1.06529261
88TCF4_22108803_ChIP-Seq_LS180_Human1.06337844
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06099480
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05481857
91TP53_16413492_ChIP-PET_HCT116_Human1.04948562
92KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04889926
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.03780119
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03123638
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.00777350
96SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99813392
97P53_22387025_ChIP-Seq_ESCs_Mouse0.99064869
98P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98861413
99FLI1_27457419_Chip-Seq_LIVER_Mouse0.98365275
100SMAD4_21741376_ChIP-Seq_EPCs_Human0.97401553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.96113922
2MP0003121_genomic_imprinting3.51425081
3MP0003890_abnormal_embryonic-extraembry2.92850538
4MP0001984_abnormal_olfaction2.85458033
5MP0005423_abnormal_somatic_nervous2.62745028
6MP0005645_abnormal_hypothalamus_physiol2.53016622
7MP0002909_abnormal_adrenal_gland2.47963441
8MP0004859_abnormal_synaptic_plasticity2.43685763
9MP0004270_analgesia2.23317964
10MP0002735_abnormal_chemical_nociception2.22927669
11MP0006276_abnormal_autonomic_nervous2.21499627
12MP0003787_abnormal_imprinting2.11881190
13MP0002272_abnormal_nervous_system2.04338072
14MP0000778_abnormal_nervous_system1.99789854
15MP0001502_abnormal_circadian_rhythm1.97925012
16MP0003635_abnormal_synaptic_transmissio1.93117222
17MP0001188_hyperpigmentation1.92771275
18MP0009745_abnormal_behavioral_response1.84976594
19MP0002837_dystrophic_cardiac_calcinosis1.82581591
20MP0002063_abnormal_learning/memory/cond1.76091678
21MP0009046_muscle_twitch1.73651851
22MP0004133_heterotaxia1.72478278
23MP0000569_abnormal_digit_pigmentation1.68097843
24MP0008877_abnormal_DNA_methylation1.67706219
25MP0002653_abnormal_ependyma_morphology1.67162060
26MP0004142_abnormal_muscle_tone1.62307472
27MP0002572_abnormal_emotion/affect_behav1.55559113
28MP0001529_abnormal_vocalization1.53263511
29MP0005187_abnormal_penis_morphology1.52181960
30MP0001968_abnormal_touch/_nociception1.51543200
31MP0001970_abnormal_pain_threshold1.48839150
32MP0006072_abnormal_retinal_apoptosis1.48322511
33MP0002734_abnormal_mechanical_nocicepti1.47274177
34MP0002184_abnormal_innervation1.45452524
35MP0003880_abnormal_central_pattern1.45361779
36MP0001440_abnormal_grooming_behavior1.42247364
37MP0002557_abnormal_social/conspecific_i1.42117354
38MP0002102_abnormal_ear_morphology1.36644019
39MP0002733_abnormal_thermal_nociception1.36144340
40MP0003567_abnormal_fetal_cardiomyocyte1.35869579
41MP0002064_seizures1.34615660
42MP0001486_abnormal_startle_reflex1.34046529
43MP0000538_abnormal_urinary_bladder1.33915984
44MP0000955_abnormal_spinal_cord1.31014546
45MP0004811_abnormal_neuron_physiology1.29218042
46MP0005394_taste/olfaction_phenotype1.28793776
47MP0005499_abnormal_olfactory_system1.28793776
48MP0004924_abnormal_behavior1.26662552
49MP0005386_behavior/neurological_phenoty1.26662552
50MP0001501_abnormal_sleep_pattern1.26294861
51MP0000566_synostosis1.26052925
52MP0005551_abnormal_eye_electrophysiolog1.26044960
53MP0005379_endocrine/exocrine_gland_phen1.19205880
54MP0002736_abnormal_nociception_after1.19087672
55MP0004885_abnormal_endolymph1.17634640
56MP0008775_abnormal_heart_ventricle1.17349046
57MP0002163_abnormal_gland_morphology1.16584308
58MP0008995_early_reproductive_senescence1.14987612
59MP0002928_abnormal_bile_duct1.13742905
60MP0002882_abnormal_neuron_morphology1.12918600
61MP0010386_abnormal_urinary_bladder1.12291345
62MP0002067_abnormal_sensory_capabilities1.10402208
63MP0000631_abnormal_neuroendocrine_gland1.08451246
64MP0001299_abnormal_eye_distance/1.07662256
65MP0002876_abnormal_thyroid_physiology1.05221206
66MP0000534_abnormal_ureter_morphology1.05176173
67MP0009780_abnormal_chondrocyte_physiolo1.04343675
68MP0008789_abnormal_olfactory_epithelium0.99337207
69MP0004145_abnormal_muscle_electrophysio0.98135181
70MP0002638_abnormal_pupillary_reflex0.96875543
71MP0002751_abnormal_autonomic_nervous0.96443444
72MP0001919_abnormal_reproductive_system0.95642278
73MP0005646_abnormal_pituitary_gland0.94864931
74MP0003942_abnormal_urinary_system0.92303156
75MP0002152_abnormal_brain_morphology0.91881188
76MP0000427_abnormal_hair_cycle0.91656410
77MP0002332_abnormal_exercise_endurance0.91510220
78MP0001905_abnormal_dopamine_level0.90830665
79MP0000013_abnormal_adipose_tissue0.90529470
80MP0000639_abnormal_adrenal_gland0.89849455
81MP0002066_abnormal_motor_capabilities/c0.89062071
82MP0004215_abnormal_myocardial_fiber0.88545495
83MP0003950_abnormal_plasma_membrane0.88504791
84MP0004043_abnormal_pH_regulation0.85032567
85MP0000026_abnormal_inner_ear0.83057475
86MP0005253_abnormal_eye_physiology0.82681685
87MP0000462_abnormal_digestive_system0.81531368
88MP0004085_abnormal_heartbeat0.79404983
89MP0003879_abnormal_hair_cell0.78608030
90MP0002069_abnormal_eating/drinking_beha0.78306884
91MP0008875_abnormal_xenobiotic_pharmacok0.78255473
92MP0005389_reproductive_system_phenotype0.78247744
93MP0002752_abnormal_somatic_nervous0.78099474
94MP0003633_abnormal_nervous_system0.76777986
95MP0002233_abnormal_nose_morphology0.75279588
96MP0002160_abnormal_reproductive_system0.74942930
97MP0003195_calcinosis0.74811565
98MP0005266_abnormal_metabolism0.73242384
99MP0000647_abnormal_sebaceous_gland0.71441227
100MP0003755_abnormal_palate_morphology0.70519351

Predicted human phenotypes

RankGene SetZ-score
1Polyphagia (HP:0002591)4.63819692
2Hypomagnesemia (HP:0002917)4.61518965
3Abnormal pancreas size (HP:0012094)4.34198942
4Occipital encephalocele (HP:0002085)3.73412019
5Abnormality of magnesium homeostasis (HP:0004921)3.68146421
6Abnormality of the labia minora (HP:0012880)3.63362232
7Type 2 muscle fiber atrophy (HP:0003554)3.63216008
8Renal salt wasting (HP:0000127)3.55186363
9Shawl scrotum (HP:0000049)3.34089218
10Failure to thrive in infancy (HP:0001531)3.33768976
11Pendular nystagmus (HP:0012043)3.13606360
12Muscle fiber atrophy (HP:0100295)3.04905610
13Hypoplasia of the brainstem (HP:0002365)2.99606384
14Aplasia/Hypoplasia of the brainstem (HP:0007362)2.99606384
15Abnormal eating behavior (HP:0100738)2.97283988
16Ankle clonus (HP:0011448)2.94027681
17Oligodactyly (hands) (HP:0001180)2.90940072
18Gait imbalance (HP:0002141)2.88637904
19Hyperventilation (HP:0002883)2.88618184
20Pachygyria (HP:0001302)2.82645823
21Medial flaring of the eyebrow (HP:0010747)2.79496578
22Polyuria (HP:0000103)2.76637995
23Narrow forehead (HP:0000341)2.72001641
24Lissencephaly (HP:0001339)2.71504851
25EEG with generalized epileptiform discharges (HP:0011198)2.64719601
26Septo-optic dysplasia (HP:0100842)2.64282813
27Labial hypoplasia (HP:0000066)2.63999511
28Congenital primary aphakia (HP:0007707)2.63397467
29Type II lissencephaly (HP:0007260)2.61969652
30Hypsarrhythmia (HP:0002521)2.61768912
31Epileptiform EEG discharges (HP:0011182)2.61748944
32Molar tooth sign on MRI (HP:0002419)2.61069136
33Abnormality of midbrain morphology (HP:0002418)2.61069136
34Unilateral renal agenesis (HP:0000122)2.59943976
35Nephrogenic diabetes insipidus (HP:0009806)2.58943424
36Pancreatic fibrosis (HP:0100732)2.47011153
37Epileptic encephalopathy (HP:0200134)2.42254461
38Genital tract atresia (HP:0001827)2.39679060
39Drooling (HP:0002307)2.38669232
40Bell-shaped thorax (HP:0001591)2.37252720
41Abnormal hair whorl (HP:0010721)2.36971770
42Abnormal urine output (HP:0012590)2.36556235
43Aplasia/Hypoplasia of the tibia (HP:0005772)2.35071648
44Congenital malformation of the right heart (HP:0011723)2.30500883
45Double outlet right ventricle (HP:0001719)2.30500883
46Sleep apnea (HP:0010535)2.29984124
47Anophthalmia (HP:0000528)2.29583617
48Hypoventilation (HP:0002791)2.28388565
49Limb dystonia (HP:0002451)2.28143283
50Hypoplastic female external genitalia (HP:0012815)2.24890494
51True hermaphroditism (HP:0010459)2.24639148
52Delayed gross motor development (HP:0002194)2.24509663
53Increased purine levels (HP:0004368)2.20486935
54Hyperuricemia (HP:0002149)2.20486935
55Anomalous pulmonary venous return (HP:0010772)2.20279033
56Agitation (HP:0000713)2.17739288
57Hypogonadotrophic hypogonadism (HP:0000044)2.17063261
58Abnormality of the aortic arch (HP:0012303)2.14340769
59Enlarged penis (HP:0000040)2.13236330
60Abnormality of renal excretion (HP:0011036)2.13036350
61Excessive salivation (HP:0003781)2.12780104
62Oligomenorrhea (HP:0000876)2.09647181
63Pancreatic cysts (HP:0001737)2.07430403
64Nephronophthisis (HP:0000090)2.06611395
65Hyponatremia (HP:0002902)2.06352131
66Esotropia (HP:0000565)2.06280543
67Vaginal atresia (HP:0000148)2.05143076
68Absent speech (HP:0001344)2.04543042
69Poor suck (HP:0002033)2.04493426
70Focal seizures (HP:0007359)2.03787367
71Hemiparesis (HP:0001269)2.03264447
72Optic nerve hypoplasia (HP:0000609)2.01715620
73Retinal dysplasia (HP:0007973)1.94811194
74Narrow nasal bridge (HP:0000446)1.92328878
75Decreased testicular size (HP:0008734)1.92118537
76Supernumerary spleens (HP:0009799)1.90232823
77Arthropathy (HP:0003040)1.88491102
78Atrioventricular canal defect (HP:0006695)1.88004025
79Oligodactyly (HP:0012165)1.87600960
80Abnormality of the labia (HP:0000058)1.87404520
81Abnormality of the pulmonary veins (HP:0011718)1.85385203
82Hypoplasia of the corpus callosum (HP:0002079)1.85180373
83Postaxial hand polydactyly (HP:0001162)1.82287279
84Short foot (HP:0001773)1.81182035
85Hyperinsulinemic hypoglycemia (HP:0000825)1.79830319
86Specific learning disability (HP:0001328)1.77706717
87Abnormality of the renal medulla (HP:0100957)1.76358634
88Poor coordination (HP:0002370)1.74842127
89Short tibia (HP:0005736)1.74736182
90Spastic tetraplegia (HP:0002510)1.73763463
91Dialeptic seizures (HP:0011146)1.73535447
92Large eyes (HP:0001090)1.73038394
93Oculomotor apraxia (HP:0000657)1.72895213
94Hypothermia (HP:0002045)1.71851572
95Abnormality of sodium homeostasis (HP:0010931)1.71031661
96Polymicrogyria (HP:0002126)1.69704969
97Metaphyseal dysplasia (HP:0100255)1.69423245
98Bony spicule pigmentary retinopathy (HP:0007737)1.67787769
99Alkalosis (HP:0001948)1.67654431
100Highly arched eyebrow (HP:0002553)1.67174960

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB33.93204397
2MST43.92023530
3MARK13.78549209
4FRK3.62482727
5TNIK3.57238605
6CASK3.48132351
7MAP3K42.80037981
8MAPK132.44551422
9BCR2.19931092
10TRIM281.99171042
11DYRK21.79744434
12PLK21.76784904
13MAP2K71.76374930
14NTRK31.71292382
15FGFR21.65634977
16MAP4K21.62004110
17NTRK21.61719293
18PRKCE1.59292372
19AKT31.48453087
20CSNK1G21.48175493
21FER1.44968938
22WNK31.42839750
23PAK31.41742604
24UHMK11.38191876
25MINK11.35204169
26PINK11.30460102
27STK38L1.23617150
28PNCK1.23557163
29PAK61.17259903
30PRKCG1.10883056
31NTRK11.10727835
32MAP3K91.09720787
33ADRBK21.08180304
34EPHA31.05416890
35SIK20.99413206
36CAMK2A0.95475043
37GRK10.94670544
38DYRK30.94563812
39MAP3K60.94245022
40SGK4940.94231001
41SGK2230.94231001
42CSNK1G10.93359614
43PHKG20.90512456
44PHKG10.90512456
45CDK50.85512174
46MAP2K40.84822999
47CAMK2D0.82871260
48STK390.82757262
49INSRR0.82729013
50CAMK2B0.82721723
51RPS6KA40.81766149
52SGK20.81025852
53MKNK20.80682541
54CLK10.77661105
55CSNK1G30.75156740
56PRKG10.67323326
57PRKACA0.67129885
58LATS10.66864600
59ROCK20.66029099
60DAPK20.65258090
61STK240.64551951
62GRK70.62716214
63PKN20.60715632
64CDK140.58652597
65KSR10.57493607
66PRKCZ0.57323888
67CSNK1A1L0.56187635
68ADRBK10.56070482
69NUAK10.55945095
70ROCK10.54114086
71TAOK30.52582978
72DMPK0.52416852
73PRKACB0.51415747
74PKN10.49794018
75CDK180.48783389
76WNK40.48734819
77RPS6KA50.46497605
78CSNK1E0.46351477
79CSNK1D0.46263473
80EPHB20.45566046
81SIK30.44408674
82BMPR1B0.44206979
83CDK150.42958806
84EGFR0.42617681
85CDK30.42543564
86PRKACG0.41551288
87NLK0.39807263
88CAMK2G0.38754756
89RPS6KA30.38196760
90CSNK1A10.37442372
91CAMK40.36723187
92MOS0.35950841
93PRKCA0.35949640
94CDK90.35751285
95CDK11A0.35014674
96PLK30.34863343
97STK30.34670821
98EPHA40.34584415
99DYRK1A0.33479218
100OXSR10.33404060

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.73191347
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.59746434
3GABAergic synapse_Homo sapiens_hsa047272.46270801
4Synaptic vesicle cycle_Homo sapiens_hsa047212.19781299
5Butanoate metabolism_Homo sapiens_hsa006502.12848760
6Steroid biosynthesis_Homo sapiens_hsa001002.08772502
7Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.07523788
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.06592729
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.03006253
10Glutamatergic synapse_Homo sapiens_hsa047242.02239114
11Morphine addiction_Homo sapiens_hsa050322.02056975
12Circadian entrainment_Homo sapiens_hsa047132.02024108
13Protein export_Homo sapiens_hsa030601.98020824
14Cocaine addiction_Homo sapiens_hsa050301.97413303
15Phototransduction_Homo sapiens_hsa047441.95217245
16Dopaminergic synapse_Homo sapiens_hsa047281.91798115
17Amphetamine addiction_Homo sapiens_hsa050311.81650462
18Insulin secretion_Homo sapiens_hsa049111.80196674
19Collecting duct acid secretion_Homo sapiens_hsa049661.77161649
20Circadian rhythm_Homo sapiens_hsa047101.63993461
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.62463539
22Taste transduction_Homo sapiens_hsa047421.57078321
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53597686
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50890742
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.49215163
26Serotonergic synapse_Homo sapiens_hsa047261.47991195
27Olfactory transduction_Homo sapiens_hsa047401.44678151
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41761904
29Ovarian steroidogenesis_Homo sapiens_hsa049131.39105565
30Long-term depression_Homo sapiens_hsa047301.36366251
31Vibrio cholerae infection_Homo sapiens_hsa051101.28725912
32Type II diabetes mellitus_Homo sapiens_hsa049301.24661774
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22060830
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22011910
35Renin secretion_Homo sapiens_hsa049241.17973095
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15291203
37Propanoate metabolism_Homo sapiens_hsa006401.04487339
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02621889
39Oxidative phosphorylation_Homo sapiens_hsa001901.01723349
40Cholinergic synapse_Homo sapiens_hsa047251.00188552
41Axon guidance_Homo sapiens_hsa043600.99968709
42Sphingolipid metabolism_Homo sapiens_hsa006000.93330128
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92902694
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91699612
45Hedgehog signaling pathway_Homo sapiens_hsa043400.90520994
46Cardiac muscle contraction_Homo sapiens_hsa042600.89502243
47Gastric acid secretion_Homo sapiens_hsa049710.87651530
48Gap junction_Homo sapiens_hsa045400.86633000
49Long-term potentiation_Homo sapiens_hsa047200.81846857
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79507448
51cAMP signaling pathway_Homo sapiens_hsa040240.78651347
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77161069
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75082956
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74895341
55Salivary secretion_Homo sapiens_hsa049700.72144175
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70829395
57Hippo signaling pathway_Homo sapiens_hsa043900.65872949
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64531574
59Dorso-ventral axis formation_Homo sapiens_hsa043200.63975027
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63045917
61Oxytocin signaling pathway_Homo sapiens_hsa049210.62881121
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.62653116
63Parkinsons disease_Homo sapiens_hsa050120.60223509
64Ether lipid metabolism_Homo sapiens_hsa005650.59718784
65Fatty acid biosynthesis_Homo sapiens_hsa000610.59587768
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59106307
67Alzheimers disease_Homo sapiens_hsa050100.58159724
68Tight junction_Homo sapiens_hsa045300.57435628
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56834376
70Ras signaling pathway_Homo sapiens_hsa040140.56124050
71Linoleic acid metabolism_Homo sapiens_hsa005910.55821369
72Estrogen signaling pathway_Homo sapiens_hsa049150.54450968
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54319894
74Alcoholism_Homo sapiens_hsa050340.52772209
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51161258
76Basal transcription factors_Homo sapiens_hsa030220.50600549
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50593227
78AMPK signaling pathway_Homo sapiens_hsa041520.50356748
79Caffeine metabolism_Homo sapiens_hsa002320.49221680
80Regulation of autophagy_Homo sapiens_hsa041400.48905179
81Fatty acid metabolism_Homo sapiens_hsa012120.47414595
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47374502
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47233608
84Melanogenesis_Homo sapiens_hsa049160.46315226
85RNA degradation_Homo sapiens_hsa030180.45486254
86Folate biosynthesis_Homo sapiens_hsa007900.41836024
87Thyroid hormone synthesis_Homo sapiens_hsa049180.41631409
88Pancreatic secretion_Homo sapiens_hsa049720.40911226
89Glucagon signaling pathway_Homo sapiens_hsa049220.40818613
90Oocyte meiosis_Homo sapiens_hsa041140.40430501
91Selenocompound metabolism_Homo sapiens_hsa004500.40400911
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.38068030
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37802084
94Huntingtons disease_Homo sapiens_hsa050160.37323823
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36894217
96Calcium signaling pathway_Homo sapiens_hsa040200.36045943
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35344871
98Tryptophan metabolism_Homo sapiens_hsa003800.35258963
99Chemical carcinogenesis_Homo sapiens_hsa052040.35082067
100Melanoma_Homo sapiens_hsa052180.34055490

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