ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	RNA destabilization (GO:0050779)	6.54829268
2	positive regulation of protein deacetylation (GO:0090312)	5.43401561
3	tryptophan catabolic process (GO:0006569)	4.51940856
4	indole-containing compound catabolic process (GO:0042436)	4.51940856
5	indolalkylamine catabolic process (GO:0046218)	4.51940856
6	cell wall macromolecule metabolic process (GO:0044036)	4.51170375
7	tryptophan metabolic process (GO:0006568)	4.29661741
8	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	4.26064096
9	cell wall macromolecule catabolic process (GO:0016998)	4.21519237
10	ovulation from ovarian follicle (GO:0001542)	3.97933173
11	retinal ganglion cell axon guidance (GO:0031290)	3.95973180
12	regulation of cilium movement (GO:0003352)	3.86194776
13	kynurenine metabolic process (GO:0070189)	3.73981693
14	somite rostral/caudal axis specification (GO:0032525)	3.63321443
15	regulation of cytokine secretion involved in immune response (GO:0002739)	3.51195095
16	acrosome reaction (GO:0007340)	3.49461511
17	response to misfolded protein (GO:0051788)	3.46087209
18	left/right axis specification (GO:0070986)	3.40446586
19	sperm motility (GO:0030317)	3.38875388
20	cellular ketone body metabolic process (GO:0046950)	3.35699332
21	positive regulation of action potential (GO:0045760)	3.35275080
22	negative regulation of nitric oxide biosynthetic process (GO:0045019)	3.35067681
23	negative regulation of macroautophagy (GO:0016242)	3.31345944
24	negative regulation of viral entry into host cell (GO:0046597)	3.30866329
25	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.30628084
26	forebrain neuron development (GO:0021884)	3.23876600
27	neurotransmitter-gated ion channel clustering (GO:0072578)	3.23432952
28	amine catabolic process (GO:0009310)	3.20248076
29	cellular biogenic amine catabolic process (GO:0042402)	3.20248076
30	indolalkylamine metabolic process (GO:0006586)	3.11377389
31	regulation of protein deacetylation (GO:0090311)	3.10176064
32	peptide catabolic process (GO:0043171)	3.08203744
33	membrane budding (GO:0006900)	3.02929359
34	fusion of sperm to egg plasma membrane (GO:0007342)	3.02823508
35	interleukin-6-mediated signaling pathway (GO:0070102)	2.99067147
36	positive regulation of cellular amide metabolic process (GO:0034250)	2.95007464
37	mature B cell differentiation involved in immune response (GO:0002313)	2.93933041
38	prenylation (GO:0097354)	2.93638581
39	protein prenylation (GO:0018342)	2.93638581
40	negative regulation of lipid storage (GO:0010888)	2.93097133
41	virion attachment to host cell (GO:0019062)	2.88409974
42	adhesion of symbiont to host cell (GO:0044650)	2.88409974
43	heart contraction (GO:0060047)	2.85336090
44	heart process (GO:0003015)	2.85336090
45	negative regulation of signal transduction by p53 class mediator (GO:1901797)	2.83881149
46	epithelial cilium movement (GO:0003351)	2.82302658
47	regulation of microtubule-based movement (GO:0060632)	2.82094870
48	regulation of T-helper 1 cell differentiation (GO:0045625)	2.79542853
49	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.78367821
50	negative regulation of protein localization to cell surface (GO:2000009)	2.77032393
51	ketone body metabolic process (GO:1902224)	2.76558303
52	multicellular organism reproduction (GO:0032504)	2.72853628
53	oligosaccharide catabolic process (GO:0009313)	2.72764038
54	interferon-gamma production (GO:0032609)	2.72311999
55	circadian sleep/wake cycle process (GO:0022410)	2.71170310
56	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	2.71082495
57	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.67921753
58	regulation of viral entry into host cell (GO:0046596)	2.67851551
59	interkinetic nuclear migration (GO:0022027)	2.65671577
60	myelin assembly (GO:0032288)	2.65261912
61	ADP metabolic process (GO:0046031)	2.53949620
62	substrate-dependent cell migration (GO:0006929)	2.53452668
63	arachidonic acid secretion (GO:0050482)	2.53408874
64	icosanoid secretion (GO:0032309)	2.53408874
65	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	2.53214913
66	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.52875497
67	cell adhesion mediated by integrin (GO:0033627)	2.52337585
68	keratan sulfate catabolic process (GO:0042340)	2.51402525
69	ovulation (GO:0030728)	2.50720014
70	activation of protein kinase B activity (GO:0032148)	2.48659094
71	positive regulation of gastrulation (GO:2000543)	2.47801056
72	plasma membrane fusion (GO:0045026)	2.47606710
73	response to folic acid (GO:0051593)	2.47560595
74	establishment of protein localization to Golgi (GO:0072600)	2.46194550
75	activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)	2.44148383
76	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.42954319
77	aromatic amino acid family catabolic process (GO:0009074)	2.40879231
78	negative regulation of smooth muscle cell migration (GO:0014912)	2.39847043
79	negative regulation of activin receptor signaling pathway (GO:0032926)	2.39758983
80	negative regulation of amino acid transport (GO:0051956)	2.39189560
81	branching involved in labyrinthine layer morphogenesis (GO:0060670)	2.37909185
82	negative regulation of cAMP-mediated signaling (GO:0043951)	2.35900580
83	regulation of mononuclear cell migration (GO:0071675)	2.34310910
84	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.33552265
85	carnitine shuttle (GO:0006853)	2.31859345
86	adhesion of symbiont to host (GO:0044406)	2.31151190
87	hemoglobin metabolic process (GO:0020027)	2.30172221
88	short-term memory (GO:0007614)	2.30150514
89	cardiac myofibril assembly (GO:0055003)	2.29961326
90	negative regulation of chemotaxis (GO:0050922)	2.29746904
91	myofibril assembly (GO:0030239)	2.29661843
92	protein polyglutamylation (GO:0018095)	2.29616046
93	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.28573528
94	regulation of membrane protein ectodomain proteolysis (GO:0051043)	2.28339263
95	positive regulation of lipid storage (GO:0010884)	2.26814135
96	amino sugar catabolic process (GO:0046348)	2.26565792
97	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.25967847
98	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.25967847
99	regulation of lipid storage (GO:0010883)	2.25920509
100	motile cilium assembly (GO:0044458)	2.25650157

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.46574623
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.39880234
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.24754578
4	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.97204480
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.56853241
6	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.51003219
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.25987077
8	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.19607312
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.19575574
10	TP53_16413492_ChIP-PET_HCT116_Human	2.18798748
11	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.17257857
12	FUS_26573619_Chip-Seq_HEK293_Human	2.16764324
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.07054796
14	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.04474808
15	VDR_24787735_ChIP-Seq_THP-1_Human	2.03598749
16	TCF4_18268006_ChIP-ChIP_LS174T_Human	2.02311778
17	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.95943470
18	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.91377303
19	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.89517214
20	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.88023158
21	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.86961113
22	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.86961113
23	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.85634619
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.84504537
25	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.81348321
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.77064906
27	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.70503304
28	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.66828602
29	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.65577987
30	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.60447931
31	P300_19829295_ChIP-Seq_ESCs_Human	1.60346377
32	* CJUN_26792858_Chip-Seq_BT549_Human	1.58949844
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.55920889
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.55920889
35	* ARNT_22903824_ChIP-Seq_MCF-7_Human	1.54965567
36	TP53_18474530_ChIP-ChIP_U2OS_Human	1.53541904
37	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.51420477
38	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.51093070
39	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.50967215
40	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.48583159
41	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.44702406
42	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44282171
43	VDR_22108803_ChIP-Seq_LS180_Human	1.44226262
44	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.43759773
45	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.40752798
46	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.40414245
47	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.39999659
48	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.39999659
49	TAF15_26573619_Chip-Seq_HEK293_Human	1.39905127
50	KDM2B_26808549_Chip-Seq_REH_Human	1.39448878
51	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.37264318
52	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.37093846
53	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.36977244
54	* AHR_22903824_ChIP-Seq_MCF-7_Human	1.36700958
55	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.34475165
56	* STAT3_23295773_ChIP-Seq_U87_Human	1.33299966
57	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.31660722
58	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.31495124
59	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.31299101
60	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.31269847
61	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.30716814
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30164376
63	* TCF4_23295773_ChIP-Seq_U87_Human	1.30111452
64	* NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28276618
65	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.27767634
66	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.27023995
67	BCAT_22108803_ChIP-Seq_LS180_Human	1.26952199
68	* ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.26377381
69	P53_22387025_ChIP-Seq_ESCs_Mouse	1.25063082
70	EZH2_22144423_ChIP-Seq_EOC_Human	1.22482052
71	* SMAD3_21741376_ChIP-Seq_EPCs_Human	1.21837174
72	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21317376
73	* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.20625475
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19724737
75	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19724737
76	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.19584296
77	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.19546293
78	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.17753701
79	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.14843280
80	AR_25329375_ChIP-Seq_VCAP_Human	1.13928530
81	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.11627573
82	P300_18555785_Chip-Seq_ESCs_Mouse	1.11130184
83	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.10815694
84	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.10067255
85	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.07717419
86	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.06683907
87	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.06280503
88	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.05369386
89	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.05210808
90	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.04816656
91	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.04476294
92	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.04348889
93	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.03382971
94	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.03020797
95	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.02415389
96	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.99710957
97	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.99243654
98	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.98590242
99	ER_23166858_ChIP-Seq_MCF-7_Human	0.98398864
100	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.97785082

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003950_abnormal_plasma_membrane	3.98837146
2	MP0005670_abnormal_white_adipose	3.83850579
3	MP0010368_abnormal_lymphatic_system	3.34345430
4	MP0003183_abnormal_peptide_metabolism	3.00345015
5	MP0001501_abnormal_sleep_pattern	2.94807186
6	MP0003195_calcinosis	2.63228982
7	MP0005410_abnormal_fertilization	2.60881083
8	MP0002837_dystrophic_cardiac_calcinosis	2.50828225
9	MP0004510_myositis	2.43132094
10	MP0005058_abnormal_lysosome_morphology	2.42313162
11	MP0003646_muscle_fatigue	2.34495189
12	MP0000569_abnormal_digit_pigmentation	2.21300798
13	MP0004215_abnormal_myocardial_fiber	2.20413581
14	MP0005666_abnormal_adipose_tissue	2.20394449
15	MP0004272_abnormal_basement_membrane	2.16551013
16	MP0005367_renal/urinary_system_phenotyp	2.13369496
17	MP0000516_abnormal_urinary_system	2.13369496
18	MP0008438_abnormal_cutaneous_collagen	2.12114609
19	MP0003890_abnormal_embryonic-extraembry	2.01974838
20	MP0008961_abnormal_basal_metabolism	1.98745626
21	MP0008004_abnormal_stomach_pH	1.94020180
22	MP0005375_adipose_tissue_phenotype	1.88615286
23	MP0000013_abnormal_adipose_tissue	1.86626743
24	MP0004084_abnormal_cardiac_muscle	1.81430246
25	MP0009840_abnormal_foam_cell	1.77465218
26	MP0003879_abnormal_hair_cell	1.76021293
27	MP0001958_emphysema	1.75662883
28	MP0006054_spinal_hemorrhage	1.71535312
29	MP0000749_muscle_degeneration	1.70104299
30	MP0005275_abnormal_skin_tensile	1.65258230
31	MP0000372_irregular_coat_pigmentation	1.64008755
32	MP0003279_aneurysm	1.54690583
33	MP0010386_abnormal_urinary_bladder	1.46216546
34	MP0005595_abnormal_vascular_smooth	1.41295152
35	MP0004036_abnormal_muscle_relaxation	1.37453076
36	MP0009115_abnormal_fat_cell	1.32990484
37	MP0002127_abnormal_cardiovascular_syste	1.30664747
38	MP0002148_abnormal_hypersensitivity_rea	1.29553349
39	MP0006082_CNS_inflammation	1.29106091
40	MP0005257_abnormal_intraocular_pressure	1.22000153
41	MP0005620_abnormal_muscle_contractility	1.19918833
42	MP0001533_abnormal_skeleton_physiology	1.19078406
43	MP0009780_abnormal_chondrocyte_physiolo	1.18608390
44	MP0001853_heart_inflammation	1.15014420
45	MP0001542_abnormal_bone_strength	1.12565706
46	MP0003690_abnormal_glial_cell	1.12000685
47	MP0001485_abnormal_pinna_reflex	1.11841629
48	MP0003724_increased_susceptibility_to	1.11436654
49	MP0000604_amyloidosis	1.11047419
50	MP0001984_abnormal_olfaction	1.10511358
51	MP0000343_altered_response_to	1.07530619
52	MP0002971_abnormal_brown_adipose	1.07344055
53	MP0004043_abnormal_pH_regulation	1.06814062
54	MP0005503_abnormal_tendon_morphology	1.06608225
55	MP0000003_abnormal_adipose_tissue	1.06500335
56	MP0006072_abnormal_retinal_apoptosis	1.06112618
57	MP0002736_abnormal_nociception_after	1.06082255
58	MP0002933_joint_inflammation	1.04296103
59	MP0002938_white_spotting	1.00116875
60	MP0005377_hearing/vestibular/ear_phenot	0.97602749
61	MP0003878_abnormal_ear_physiology	0.97602749
62	MP0005508_abnormal_skeleton_morphology	0.97468198
63	MP0009785_altered_susceptibility_to	0.96491520
64	MP0002332_abnormal_exercise_endurance	0.95638512
65	MP0004859_abnormal_synaptic_plasticity	0.94288657
66	MP0003191_abnormal_cellular_cholesterol	0.94026798
67	MP0005390_skeleton_phenotype	0.93250643
68	MP0009046_muscle_twitch	0.92786173
69	MP0000751_myopathy	0.92772751
70	MP0005334_abnormal_fat_pad	0.92457576
71	MP0010329_abnormal_lipoprotein_level	0.91687404
72	MP0002295_abnormal_pulmonary_circulatio	0.90892803
73	MP0005253_abnormal_eye_physiology	0.89788872
74	MP0002998_abnormal_bone_remodeling	0.89161809
75	MP0003656_abnormal_erythrocyte_physiolo	0.87896394
76	MP0005551_abnormal_eye_electrophysiolog	0.86248428
77	MP0002090_abnormal_vision	0.85823164
78	MP0002108_abnormal_muscle_morphology	0.84517250
79	MP0003172_abnormal_lysosome_physiology	0.84036970
80	MP0005164_abnormal_response_to	0.82717396
81	MP0003633_abnormal_nervous_system	0.81631879
82	MP0008775_abnormal_heart_ventricle	0.80911449
83	MP0009384_cardiac_valve_regurgitation	0.80028863
84	MP0005174_abnormal_tail_pigmentation	0.78772854
85	MP0005671_abnormal_response_to	0.78757744
86	MP0001764_abnormal_homeostasis	0.78692648
87	MP0009765_abnormal_xenobiotic_induced	0.78261387
88	MP0002115_abnormal_skeleton_extremities	0.77607470
89	MP0002638_abnormal_pupillary_reflex	0.73585876
90	MP0004133_heterotaxia	0.72802372
91	MP0002972_abnormal_cardiac_muscle	0.72757653
92	MP0002572_abnormal_emotion/affect_behav	0.71354541
93	MP0004264_abnormal_extraembryonic_tissu	0.71075945
94	MP0003091_abnormal_cell_migration	0.70653523
95	MP0003880_abnormal_central_pattern	0.70385379
96	MP0001440_abnormal_grooming_behavior	0.70204655
97	MP0004130_abnormal_muscle_cell	0.69211827
98	MP0009250_abnormal_appendicular_skeleto	0.68958395
99	MP0009764_decreased_sensitivity_to	0.68785982
100	MP0001905_abnormal_dopamine_level	0.68319518

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Failure to thrive in infancy (HP:0001531)	7.25558188
2	Abnormality of glycolipid metabolism (HP:0010969)	4.94717801
3	Abnormality of liposaccharide metabolism (HP:0010968)	4.94717801
4	Abnormality of glycosphingolipid metabolism (HP:0004343)	4.94717801
5	Febrile seizures (HP:0002373)	4.06659362
6	Vacuolated lymphocytes (HP:0001922)	3.78214379
7	Spondylolisthesis (HP:0003302)	3.77845751
8	Asymmetric septal hypertrophy (HP:0001670)	3.43837966
9	Amniotic constriction ring (HP:0009775)	3.29632944
10	Abnormality of placental membranes (HP:0011409)	3.29632944
11	Dysostosis multiplex (HP:0000943)	3.11417068
12	Mutism (HP:0002300)	2.87799287
13	Abnormality of lateral ventricle (HP:0030047)	2.87221333
14	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.81095423
15	Apathy (HP:0000741)	2.76074066
16	Peritonitis (HP:0002586)	2.63074901
17	Diminished motivation (HP:0000745)	2.57079281
18	Rib fusion (HP:0000902)	2.55762136
19	Disinhibition (HP:0000734)	2.49975073
20	Aortic aneurysm (HP:0004942)	2.47637596
21	Papillary thyroid carcinoma (HP:0002895)	2.47178081
22	Severe visual impairment (HP:0001141)	2.47058181
23	Ankle contracture (HP:0006466)	2.44764999
24	Spontaneous abortion (HP:0005268)	2.43418990
25	Generalized aminoaciduria (HP:0002909)	2.42806129
26	Nausea (HP:0002018)	2.39147533
27	Progressive external ophthalmoplegia (HP:0000590)	2.35994357
28	Potter facies (HP:0002009)	2.34517842
29	Facial shape deformation (HP:0011334)	2.34517842
30	Abnormality of dental color (HP:0011073)	2.34115522
31	Atrophic scars (HP:0001075)	2.29700742
32	Glucose intolerance (HP:0000833)	2.28965039
33	Gowers sign (HP:0003391)	2.27192439
34	Loss of speech (HP:0002371)	2.24318849
35	Severe global developmental delay (HP:0011344)	2.24029142
36	Decreased subcutaneous fat (HP:0001002)	2.23970807
37	Chin dimple (HP:0010751)	2.23856554
38	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.20836160
39	Poor head control (HP:0002421)	2.20342265
40	Absent/shortened dynein arms (HP:0200106)	2.19753822
41	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.19753822
42	Systemic lupus erythematosus (HP:0002725)	2.16296597
43	Nonprogressive disorder (HP:0003680)	2.16007567
44	Axonal loss (HP:0003447)	2.13419577
45	Soft skin (HP:0000977)	2.12200633
46	Chronic hepatic failure (HP:0100626)	2.06604581
47	Methylmalonic acidemia (HP:0002912)	2.06440058
48	Fatigable weakness (HP:0003473)	2.04407209
49	Abnormality of the neuromuscular junction (HP:0003398)	2.04407209
50	Aortic dissection (HP:0002647)	2.03105919
51	Coxa valga (HP:0002673)	2.02925756
52	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.02821742
53	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	2.00622090
54	Narrow forehead (HP:0000341)	1.99112411
55	Easy fatigability (HP:0003388)	1.96861988
56	Split foot (HP:0001839)	1.96464513
57	Congenital sensorineural hearing impairment (HP:0008527)	1.96252241
58	Follicular hyperkeratosis (HP:0007502)	1.93289861
59	Reduced antithrombin III activity (HP:0001976)	1.91933672
60	Prolonged neonatal jaundice (HP:0006579)	1.87421407
61	Hoarse voice (HP:0001609)	1.85315494
62	Rhabdomyolysis (HP:0003201)	1.84933504
63	Anhidrosis (HP:0000970)	1.82819035
64	Exercise-induced myalgia (HP:0003738)	1.82681398
65	Abnormality of polysaccharide metabolism (HP:0011012)	1.81646686
66	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.81646686
67	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.81646686
68	Eosinophilia (HP:0001880)	1.80944527
69	Increased number of teeth (HP:0011069)	1.80901696
70	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.80737162
71	Abnormality of methionine metabolism (HP:0010901)	1.79668285
72	Hypoplastic ischia (HP:0003175)	1.79554514
73	Abnormality of the frontal sinuses (HP:0002687)	1.79506836
74	Popliteal pterygium (HP:0009756)	1.79343483
75	Neonatal short-limb short stature (HP:0008921)	1.77956940
76	Hypoalphalipoproteinemia (HP:0003233)	1.77223106
77	Medial flaring of the eyebrow (HP:0010747)	1.76228353
78	Malignant hyperthermia (HP:0002047)	1.75099307
79	Aortic regurgitation (HP:0001659)	1.73385976
80	Abnormal respiratory epithelium morphology (HP:0012253)	1.72895623
81	Abnormal respiratory motile cilium morphology (HP:0005938)	1.72895623
82	Knee flexion contracture (HP:0006380)	1.71831878
83	Premature rupture of membranes (HP:0001788)	1.70450542
84	Sudden death (HP:0001699)	1.69919312
85	Spinal rigidity (HP:0003306)	1.68796877
86	Intestinal atresia (HP:0011100)	1.67956012
87	Optic neuritis (HP:0100653)	1.67288207
88	Retrobulbar optic neuritis (HP:0100654)	1.67288207
89	Orchitis (HP:0100796)	1.66729908
90	Muscular dystrophy (HP:0003560)	1.65423868
91	Fetal akinesia sequence (HP:0001989)	1.65338326
92	Abnormality of macular pigmentation (HP:0008002)	1.64412507
93	Type 2 muscle fiber atrophy (HP:0003554)	1.64398298
94	Urinary glycosaminoglycan excretion (HP:0003541)	1.64012692
95	Mucopolysacchariduria (HP:0008155)	1.64012692
96	Congenital ichthyosiform erythroderma (HP:0007431)	1.63840230
97	Persistence of primary teeth (HP:0006335)	1.61724764
98	Erythroderma (HP:0001019)	1.61676414
99	Beaking of vertebral bodies (HP:0004568)	1.61241003
100	Abnormality of the calf musculature (HP:0001430)	1.61062085

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	6.07203404
2	FGFR3	3.60693429
3	TAF1	2.89182727
4	STK38L	2.77786808
5	MARK3	2.64170979
6	MAP3K6	2.60315485
7	MAP4K2	2.41152176
8	MYLK	2.37308386
9	DDR2	2.20728012
10	MAP2K7	2.12916600
11	MUSK	2.11995324
12	MAP3K4	2.01449684
13	STK38	1.98393330
14	PINK1	1.95609729
15	WNK3	1.94296666
16	BMPR1B	1.87190707
17	KIT	1.85101532
18	DYRK1A	1.81855550
19	BLK	1.75356439
20	GRK7	1.70700956
21	MAP3K5	1.60758309
22	MATK	1.57261378
23	FLT3	1.55217277
24	PKN1	1.43428770
25	PRKD2	1.42763498
26	DYRK1B	1.40283205
27	ACVR1B	1.39639428
28	BRSK2	1.39582749
29	CASK	1.36866268
30	MOS	1.22118219
31	OBSCN	1.18306018
32	CLK1	1.16638201
33	FGR	1.13177849
34	MARK2	1.09028225
35	CDK3	1.08740801
36	TAOK2	1.08705326
37	CAMKK2	1.08680965
38	JAK3	1.04041593
39	CDC42BPA	1.02283527
40	PRPF4B	0.98953513
41	MAP2K4	0.95079637
42	PLK4	0.94470518
43	PTK2B	0.93842246
44	MAPK13	0.92598679
45	CDK19	0.92265943
46	TRPM7	0.90905358
47	EIF2AK1	0.88256221
48	ADRBK2	0.88066346
49	WNK1	0.87823339
50	MAPK12	0.86355554
51	DAPK3	0.78353866
52	TGFBR2	0.76264833
53	CSF1R	0.72995208
54	TGFBR1	0.72688376
55	ROCK1	0.69886405
56	PIK3CG	0.66456042
57	PRKACB	0.62798759
58	PRKAA2	0.62374484
59	AKT3	0.59573715
60	ZAP70	0.58290409
61	CCNB1	0.57750351
62	PAK2	0.56748526
63	DMPK	0.55837298
64	TIE1	0.54740770
65	TYK2	0.54727631
66	LATS2	0.54015599
67	PKN2	0.53181255
68	JAK1	0.52554961
69	PRKD3	0.52328279
70	FRK	0.51302192
71	CHUK	0.49701193
72	CAMK1	0.49406367
73	PRKG1	0.49346913
74	INSR	0.48585771
75	PRKG2	0.48321168
76	TESK1	0.47778534
77	PLK2	0.46201729
78	INSRR	0.44169232
79	BRD4	0.41860429
80	MAP3K7	0.41033677
81	STK10	0.40673806
82	ADRBK1	0.40533188
83	IRAK3	0.40419430
84	PIM2	0.37939431
85	LATS1	0.37858310
86	RET	0.37698789
87	ERBB3	0.36974118
88	PRKCE	0.36960859
89	ERN1	0.36188409
90	ABL1	0.35314865
91	MAPKAPK3	0.35104848
92	PRKAA1	0.34321881
93	MAP3K13	0.33411718
94	RIPK1	0.32887807
95	NEK9	0.31448712
96	ERBB4	0.30636070
97	TBK1	0.29512698
98	IGF1R	0.29294694
99	NTRK2	0.27419493
100	CAMK4	0.26760866

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Other glycan degradation_Homo sapiens_hsa00511	3.31809350
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.29977578
3	Basal transcription factors_Homo sapiens_hsa03022	2.20676912
4	Circadian rhythm_Homo sapiens_hsa04710	2.20419189
5	Propanoate metabolism_Homo sapiens_hsa00640	2.11548755
6	Malaria_Homo sapiens_hsa05144	2.04804993
7	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.01384339
8	Lysosome_Homo sapiens_hsa04142	1.99726015
9	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.92691030
10	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.85752678
11	African trypanosomiasis_Homo sapiens_hsa05143	1.80860472
12	Taste transduction_Homo sapiens_hsa04742	1.80748734
13	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.74952964
14	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.74825613
15	ECM-receptor interaction_Homo sapiens_hsa04512	1.73476154
16	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.65445181
17	Amoebiasis_Homo sapiens_hsa05146	1.64497738
18	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.61051356
19	Pertussis_Homo sapiens_hsa05133	1.54997646
20	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.54198861
21	Rheumatoid arthritis_Homo sapiens_hsa05323	1.50948632
22	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.41485537
23	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.39534710
24	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.33325735
25	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.32060916
26	Focal adhesion_Homo sapiens_hsa04510	1.30821751
27	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.29627110
28	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.27757006
29	PPAR signaling pathway_Homo sapiens_hsa03320	1.27018864
30	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.26250561
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.20249419
32	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.16678977
33	Osteoclast differentiation_Homo sapiens_hsa04380	1.13522718
34	Chemical carcinogenesis_Homo sapiens_hsa05204	1.12835708
35	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	1.10964558
36	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.10904772
37	TNF signaling pathway_Homo sapiens_hsa04668	1.09308309
38	Phototransduction_Homo sapiens_hsa04744	1.09306426
39	Complement and coagulation cascades_Homo sapiens_hsa04610	1.06501642
40	Olfactory transduction_Homo sapiens_hsa04740	1.05147112
41	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.02466059
42	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.01717909
43	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.01534403
44	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.01428890
45	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.92431990
46	Retinol metabolism_Homo sapiens_hsa00830	0.91875985
47	Glycerolipid metabolism_Homo sapiens_hsa00561	0.85716291
48	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.83646832
49	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.83636715
50	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.83500074
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.82261925
52	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.79289105
53	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.78852840
54	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.78252888
55	Butanoate metabolism_Homo sapiens_hsa00650	0.77323862
56	Sphingolipid metabolism_Homo sapiens_hsa00600	0.76106613
57	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.75792046
58	Pyruvate metabolism_Homo sapiens_hsa00620	0.74955779
59	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.73819628
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.72120964
61	Protein digestion and absorption_Homo sapiens_hsa04974	0.71351095
62	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.71053626
63	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68035690
64	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.67315302
65	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.65815629
66	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.64999078
67	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.64389984
68	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.62416974
69	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.61840791
70	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.61602885
71	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.60302395
72	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.59004995
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57374800
74	Regulation of autophagy_Homo sapiens_hsa04140	0.57275849
75	Renin-angiotensin system_Homo sapiens_hsa04614	0.54726207
76	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.54260869
77	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.52014540
78	Glucagon signaling pathway_Homo sapiens_hsa04922	0.51704114
79	Nucleotide excision repair_Homo sapiens_hsa03420	0.51115361
80	cAMP signaling pathway_Homo sapiens_hsa04024	0.50113795
81	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.48768698
82	Chemokine signaling pathway_Homo sapiens_hsa04062	0.47402533
83	Ras signaling pathway_Homo sapiens_hsa04014	0.46450869
84	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.45432735
85	Salmonella infection_Homo sapiens_hsa05132	0.45222766
86	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.45027113
87	Fatty acid degradation_Homo sapiens_hsa00071	0.44006967
88	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.43450507
89	Toxoplasmosis_Homo sapiens_hsa05145	0.43053735
90	Cardiac muscle contraction_Homo sapiens_hsa04260	0.43008035
91	Glutathione metabolism_Homo sapiens_hsa00480	0.41317275
92	Morphine addiction_Homo sapiens_hsa05032	0.39906958
93	Glutamatergic synapse_Homo sapiens_hsa04724	0.37700149
94	Proteoglycans in cancer_Homo sapiens_hsa05205	0.37431902
95	Calcium signaling pathway_Homo sapiens_hsa04020	0.37157208
96	FoxO signaling pathway_Homo sapiens_hsa04068	0.36459922
97	MAPK signaling pathway_Homo sapiens_hsa04010	0.36299449
98	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.35646682
99	Tuberculosis_Homo sapiens_hsa05152	0.35320500
100	Peroxisome_Homo sapiens_hsa04146	0.35049139

DIRC3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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