DIS3L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The cytoplasmic RNA exosome complex degrades unstable mRNAs and is involved in the regular turnover of other mRNAs. The protein encoded by this gene contains 3'-5' exoribonuclease activity and is a catalytic component of this complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm-egg recognition (GO:0035036)9.97709244
2multicellular organism reproduction (GO:0032504)9.45874220
3acrosome reaction (GO:0007340)9.31415213
4binding of sperm to zona pellucida (GO:0007339)9.29258275
5axonemal dynein complex assembly (GO:0070286)9.19781433
6cell-cell recognition (GO:0009988)8.97042743
7male meiosis (GO:0007140)8.57578815
8plasma membrane fusion (GO:0045026)8.49820356
9spermatid development (GO:0007286)8.32270163
10motile cilium assembly (GO:0044458)8.15746683
11epithelial cilium movement (GO:0003351)8.01245262
12cell wall macromolecule metabolic process (GO:0044036)8.01046893
13cell wall macromolecule catabolic process (GO:0016998)8.01046893
14synaptonemal complex organization (GO:0070193)7.95087300
15reproduction (GO:0000003)7.73040038
16synaptonemal complex assembly (GO:0007130)7.67218984
17regulation of cilium movement (GO:0003352)7.14031964
18cilium movement (GO:0003341)7.06420286
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.85871711
20DNA methylation involved in gamete generation (GO:0043046)6.38581518
21single fertilization (GO:0007338)6.31065736
22male meiosis I (GO:0007141)6.27566770
23sperm capacitation (GO:0048240)6.11809139
24negative regulation of inclusion body assembly (GO:0090084)5.86463619
25behavioral response to nicotine (GO:0035095)5.76023538
26fertilization (GO:0009566)5.57912301
27chromosome organization involved in meiosis (GO:0070192)5.42672304
28spermatogenesis (GO:0007283)5.41779924
29male gamete generation (GO:0048232)5.39837347
30organic cation transport (GO:0015695)5.25169965
31meiosis I (GO:0007127)5.07707879
32meiotic nuclear division (GO:0007126)5.04020159
33gamete generation (GO:0007276)5.00505455
34cellular process involved in reproduction in multicellular organism (GO:0022412)4.86020154
35germ cell development (GO:0007281)4.80296208
36regulation of inclusion body assembly (GO:0090083)4.75811805
37meiotic cell cycle (GO:0051321)4.64540450
38microtubule severing (GO:0051013)4.61348451
39carnitine transmembrane transport (GO:1902603)4.58661325
40amino-acid betaine transport (GO:0015838)4.53433056
41carnitine transport (GO:0015879)4.53433056
42microtubule depolymerization (GO:0007019)4.47345269
43calcium ion-dependent exocytosis (GO:0017156)4.38729256
44seminiferous tubule development (GO:0072520)4.36883775
45DNA deamination (GO:0045006)4.36336942
46gene silencing by RNA (GO:0031047)4.21003177
47water-soluble vitamin biosynthetic process (GO:0042364)4.20146054
48regulation of microtubule-based movement (GO:0060632)4.18188759
49cell recognition (GO:0008037)4.18104254
50left/right pattern formation (GO:0060972)4.17614063
51monoubiquitinated protein deubiquitination (GO:0035520)4.13887523
52ventricular system development (GO:0021591)4.03790455
53genitalia morphogenesis (GO:0035112)4.01618161
54multicellular organismal reproductive process (GO:0048609)3.92325503
55regulation of mitochondrial translation (GO:0070129)3.90057420
56protein localization to cilium (GO:0061512)3.69227982
57L-fucose catabolic process (GO:0042355)3.64522482
58fucose catabolic process (GO:0019317)3.64522482
59L-fucose metabolic process (GO:0042354)3.64522482
60somatic hypermutation of immunoglobulin genes (GO:0016446)3.59935979
61somatic diversification of immune receptors via somatic mutation (GO:0002566)3.59935979
62protein K6-linked ubiquitination (GO:0085020)3.59218323
63regulation of meiosis I (GO:0060631)3.57947787
64regulation of mesoderm development (GO:2000380)3.54684688
65protein polyglutamylation (GO:0018095)3.54141000
66negative regulation of organelle assembly (GO:1902116)3.51127437
67glycerol ether metabolic process (GO:0006662)3.49253917
68synapsis (GO:0007129)3.47934260
69* RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.46185331
70somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.45560938
71somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.45560938
72isotype switching (GO:0045190)3.45560938
73replication fork processing (GO:0031297)3.41490234
74regulation of nuclear cell cycle DNA replication (GO:0033262)3.37500024
75polyol catabolic process (GO:0046174)3.37477571
76meiotic cell cycle process (GO:1903046)3.36613227
77kynurenine metabolic process (GO:0070189)3.35868382
78chromosome condensation (GO:0030261)3.34355163
79lactate metabolic process (GO:0006089)3.30827646
80peptidyl-glutamic acid modification (GO:0018200)3.29984005
81quaternary ammonium group transport (GO:0015697)3.26855697
82glycolytic process (GO:0006096)3.23445374
83regulation of memory T cell differentiation (GO:0043380)3.21344636
84negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.20070908
85chaperone-mediated protein complex assembly (GO:0051131)3.19467991
86mitotic sister chromatid cohesion (GO:0007064)3.17569098
87ether metabolic process (GO:0018904)3.17193202
88DNA packaging (GO:0006323)3.14464331
89double-strand break repair via homologous recombination (GO:0000724)3.13991059
90respiratory chain complex IV assembly (GO:0008535)3.13302910
91recombinational repair (GO:0000725)3.12653127
92DNA double-strand break processing (GO:0000729)3.11576431
93negative regulation of telomere maintenance (GO:0032205)3.09496823
94negative regulation of transcription regulatory region DNA binding (GO:2000678)3.09386430
95reciprocal DNA recombination (GO:0035825)3.09013669
96reciprocal meiotic recombination (GO:0007131)3.09013669
97multicellular organismal development (GO:0007275)3.07521819
98tricarboxylic acid cycle (GO:0006099)3.06816945
99nuclear pore complex assembly (GO:0051292)3.04390140
100fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.04133346
101regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.01273144
102regulation of mitotic spindle checkpoint (GO:1903504)3.01273144
103intraciliary transport (GO:0042073)2.99286373
104DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.97352746
105gene silencing (GO:0016458)2.97100217
106cytochrome complex assembly (GO:0017004)2.94205390
107cellular ketone body metabolic process (GO:0046950)2.94099083
108somatic diversification of immunoglobulins (GO:0016445)2.92710501
109protein complex biogenesis (GO:0070271)2.92174007
110microtubule-based movement (GO:0007018)2.90525681
111alditol metabolic process (GO:0019400)2.86678476
112somatic recombination of immunoglobulin gene segments (GO:0016447)2.86531678
113negative regulation of DNA-dependent DNA replication (GO:2000104)2.86322005
114ubiquinone biosynthetic process (GO:0006744)2.84575870
115tryptophan catabolic process (GO:0006569)2.84173952
116indole-containing compound catabolic process (GO:0042436)2.84173952
117indolalkylamine catabolic process (GO:0046218)2.84173952
118preassembly of GPI anchor in ER membrane (GO:0016254)2.83528521
119somite development (GO:0061053)2.78819285
120pseudouridine synthesis (GO:0001522)2.78572956
121mitochondrial respiratory chain complex assembly (GO:0033108)2.77133275
122nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.75882707
123spermatid nucleus differentiation (GO:0007289)2.75171698
124regulation of rhodopsin mediated signaling pathway (GO:0022400)2.74118705
125exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.73351783
126carnitine shuttle (GO:0006853)2.73191465
127positive regulation of defense response to virus by host (GO:0002230)2.72558283
128L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.72116428
129metallo-sulfur cluster assembly (GO:0031163)2.69288502
130iron-sulfur cluster assembly (GO:0016226)2.69288502
131mitochondrial respiratory chain complex I assembly (GO:0032981)2.69215476
132NADH dehydrogenase complex assembly (GO:0010257)2.69215476
133mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.69215476
134tryptophan metabolic process (GO:0006568)2.67554610
135indolalkylamine metabolic process (GO:0006586)2.67192171
136rRNA modification (GO:0000154)2.66894270
137negative regulation by host of viral transcription (GO:0043922)2.66271635
138RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.66119767
139tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.66119767
140mitotic cell cycle arrest (GO:0071850)2.65886484
141DNA catabolic process, exonucleolytic (GO:0000738)2.65752368
142axoneme assembly (GO:0035082)2.65392263
143detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.64478581
144regulation of chromatin binding (GO:0035561)2.64122423
145DNA damage response, signal transduction resulting in transcription (GO:0042772)2.63326011
146maturation of 5.8S rRNA (GO:0000460)2.62663731
147regulation of spindle checkpoint (GO:0090231)2.62501553
148meiotic chromosome segregation (GO:0045132)2.62310889
149replicative senescence (GO:0090399)2.60655948
150glycerol metabolic process (GO:0006071)2.59667416
151DNA demethylation (GO:0080111)2.59428114
152ketone body metabolic process (GO:1902224)2.59357942
153sleep (GO:0030431)2.59279447
154rhodopsin mediated signaling pathway (GO:0016056)2.58920106
155regulation of hippo signaling (GO:0035330)2.57435109
156carnitine metabolic process (GO:0009437)2.57416540
157cytidine metabolic process (GO:0046087)2.55446313
158cytidine catabolic process (GO:0006216)2.55446313
159cytidine deamination (GO:0009972)2.55446313
160amino acid salvage (GO:0043102)2.55121147
161L-methionine salvage (GO:0071267)2.55121147
162L-methionine biosynthetic process (GO:0071265)2.55121147
163detection of light stimulus involved in visual perception (GO:0050908)2.55062766
164detection of light stimulus involved in sensory perception (GO:0050962)2.55062766
165adaptation of signaling pathway (GO:0023058)2.54959373
166branched-chain amino acid catabolic process (GO:0009083)2.53818123
167endoderm formation (GO:0001706)2.53714630
168positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.53597982
169regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.53597982
170maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.53417089
171ubiquinone metabolic process (GO:0006743)2.52884657
172aspartate family amino acid catabolic process (GO:0009068)2.52130118
173regulation of centriole replication (GO:0046599)2.51271131
174protein refolding (GO:0042026)2.50020921
175cellular component assembly involved in morphogenesis (GO:0010927)2.49711357
176DNA replication checkpoint (GO:0000076)2.48075518
177interferon-gamma secretion (GO:0072643)2.47944407
178pyruvate metabolic process (GO:0006090)2.47684824
179regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.46631840
180cilium organization (GO:0044782)2.46308646
181regulation of glucokinase activity (GO:0033131)2.46143201
182regulation of hexokinase activity (GO:1903299)2.46143201
183sister chromatid cohesion (GO:0007062)2.44617013
184methionine biosynthetic process (GO:0009086)2.44465987
185DNA alkylation (GO:0006305)2.44008691
186mitochondrial RNA metabolic process (GO:0000959)2.42997559
187S-adenosylmethionine metabolic process (GO:0046500)2.42775980
188cilium or flagellum-dependent cell motility (GO:0001539)12.5392179
189fusion of sperm to egg plasma membrane (GO:0007342)11.1610317
190sperm motility (GO:0030317)10.8073969
191piRNA metabolic process (GO:0034587)10.2978302
192acrosome assembly (GO:0001675)10.2112524

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.22995912
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.74247251
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.31466668
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.31127000
5IGF1R_20145208_ChIP-Seq_DFB_Human3.21437775
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.99847205
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.86560647
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.76641491
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.48029357
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.37025143
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35622071
12IRF1_19129219_ChIP-ChIP_H3396_Human2.21542354
13* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.20592288
14GBX2_23144817_ChIP-Seq_PC3_Human2.17483347
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13944507
16ZNF274_21170338_ChIP-Seq_K562_Hela2.11887898
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.10737430
18EWS_26573619_Chip-Seq_HEK293_Human2.09222116
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.5750196
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96502365
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.95786832
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.94236779
23VDR_23849224_ChIP-Seq_CD4+_Human1.92454071
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91598181
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87265123
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86595171
27E2F7_22180533_ChIP-Seq_HELA_Human1.85765736
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.82345199
29MYC_18940864_ChIP-ChIP_HL60_Human1.82277061
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.77809491
31ELK4_26923725_Chip-Seq_MESODERM_Mouse1.73809630
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72184328
33FUS_26573619_Chip-Seq_HEK293_Human1.70515395
34* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67155837
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.65987049
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.65454518
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64666999
38FOXP3_21729870_ChIP-Seq_TREG_Human1.63265292
39TP53_22573176_ChIP-Seq_HFKS_Human1.63158787
40ER_23166858_ChIP-Seq_MCF-7_Human1.62367666
41EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.62071180
42TAF15_26573619_Chip-Seq_HEK293_Human1.59871003
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.59575437
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56203147
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55739342
46WDR5_24793694_ChIP-Seq_LNCAP_Human1.53812608
47ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.53453140
48TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.51677836
49STAT1_17558387_ChIP-Seq_HELA_Human1.51199048
50GATA1_26923725_Chip-Seq_HPCs_Mouse1.50118666
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48184009
52P300_19829295_ChIP-Seq_ESCs_Human1.46940940
53IRF8_22096565_ChIP-ChIP_GC-B_Human1.45815909
54CBP_20019798_ChIP-Seq_JUKART_Human1.45338852
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45338852
56GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.44358064
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.43762635
58KAP1_22055183_ChIP-Seq_ESCs_Mouse1.41567210
59ELK1_19687146_ChIP-ChIP_HELA_Human1.41522086
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37203996
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34940114
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.33274789
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33274789
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.32603726
65AR_20517297_ChIP-Seq_VCAP_Human1.31565838
66* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29211415
67* GATA3_26560356_Chip-Seq_TH2_Human1.28960447
68SOX2_19829295_ChIP-Seq_ESCs_Human1.27667343
69NANOG_19829295_ChIP-Seq_ESCs_Human1.27667343
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26427367
71* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.26225323
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24179253
73FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24025214
74RUNX1_26923725_Chip-Seq_HPCs_Mouse1.23938477
75SOX2_22085726_ChIP-Seq_NPCs_Mouse1.22742415
76REST_21632747_ChIP-Seq_MESCs_Mouse1.22069764
77VDR_22108803_ChIP-Seq_LS180_Human1.21595092
78NCOR_22424771_ChIP-Seq_293T_Human1.21117605
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20962689
80STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.20578757
81GATA3_21867929_ChIP-Seq_CD8_Mouse1.19341171
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19294558
83LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.19118393
84KDM2B_26808549_Chip-Seq_REH_Human1.19013727
85HOXB7_26014856_ChIP-Seq_BT474_Human1.17362149
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17247826
87ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16999998
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15988211
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15604063
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15343762
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15297889
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15145837
93CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14627841
94* STAT3_23295773_ChIP-Seq_U87_Human1.14540271
95P53_21459846_ChIP-Seq_SAOS-2_Human1.12915275
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12422474
97TAL1_26923725_Chip-Seq_HPCs_Mouse1.11273985
98FLI1_21867929_ChIP-Seq_TH2_Mouse1.10945232
99LXR_22158963_ChIP-Seq_LIVER_Mouse1.10651748
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09833604
101TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09717719
102SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.09442846
103PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08662373
104RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08317173
105FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07863366
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07845654
107CRX_20693478_ChIP-Seq_RETINA_Mouse1.07603583
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07583780
109PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06650408
110CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05860918
111ELF1_20517297_ChIP-Seq_JURKAT_Human1.05453567
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04867055
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04496524
114CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04486011
115PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04214813
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03886156
117SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03783937
118AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03017784
119RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03013400
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02053180
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02053180
122LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01922892
123PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01558829
124GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00290987
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00135254
126AR_25329375_ChIP-Seq_VCAP_Human0.99544874
127ERG_20517297_ChIP-Seq_VCAP_Human0.99493103
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99358762
129PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99180649
130GATA3_21878914_ChIP-Seq_MCF-7_Human0.98214099
131RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97980944
132CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97980258
133CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97773218
134GF1_26923725_Chip-Seq_HPCs_Mouse0.97203076
135SMAD4_21799915_ChIP-Seq_A2780_Human0.96963491
136SOX2_21211035_ChIP-Seq_LN229_Human0.96941610
137SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96739201
138RARA_24833708_ChIP-Seq_LIVER_Mouse0.96397835
139BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96372831
140RXR_22158963_ChIP-Seq_LIVER_Mouse0.95915513
141GATA3_26560356_Chip-Seq_TH1_Human0.95901109
142ESET_19884257_ChIP-Seq_ESCs_Mouse0.95539999
143OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95497230
144* SPI1_26923725_Chip-Seq_HPCs_Mouse0.95476722
145MYC_27129775_Chip-Seq_CORNEA_Mouse0.95441790
146FOXH1_21741376_ChIP-Seq_EPCs_Human0.95380284
147TCF4_22108803_ChIP-Seq_LS180_Human0.94215851
148CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94038194
149SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93030409
150NANOG_20526341_ChIP-Seq_ESCs_Human0.92009581
151GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91868419
152RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91779489
153TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91192110
154GATA3_21867929_ChIP-Seq_TH1_Mouse0.90338761
155EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90335514
156PRDM14_20953172_ChIP-Seq_ESCs_Human0.89372585
157YY1_22570637_ChIP-Seq_MALME-3M_Human0.88740466
158OCT4_18555785_Chip-Seq_ESCs_Mouse0.87754001
159PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87571886
160CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87543025
161EZH2_27294783_Chip-Seq_NPCs_Mouse0.87534332
162* TBX20_22328084_ChIP-Seq_HEART_Mouse0.86883135
163* TBX20_22080862_ChIP-Seq_HEART_Mouse0.86883135
164SMAD4_21741376_ChIP-Seq_EPCs_Human0.85639024
165FOXM1_23109430_ChIP-Seq_U2OS_Human0.85151711
166TBL1_22424771_ChIP-Seq_293T_Human0.85048659
167BCAT_22108803_ChIP-Seq_LS180_Human0.83084655
168NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.81585953
169* TCF4_23295773_ChIP-Seq_U87_Human0.81486276
170NANOG_18555785_Chip-Seq_ESCs_Mouse0.80516753
171SMC4_20622854_ChIP-Seq_HELA_Human0.80307271
172GF1B_26923725_Chip-Seq_HPCs_Mouse0.80286631
173TET1_21451524_ChIP-Seq_MESCs_Mouse0.80085586
174NFYB_21822215_ChIP-Seq_K562_Human0.79758801
175P53_22387025_ChIP-Seq_ESCs_Mouse0.77691164

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.17895151
2MP0001929_abnormal_gametogenesis4.90121034
3MP0008877_abnormal_DNA_methylation4.82475113
4MP0003646_muscle_fatigue3.75341968
5MP0002210_abnormal_sex_determination3.38124651
6MP0002161_abnormal_fertility/fecundity2.91629515
7MP0006292_abnormal_olfactory_placode2.91145434
8MP0003195_calcinosis2.77536106
9MP0001145_abnormal_male_reproductive2.76882311
10MP0002653_abnormal_ependyma_morphology2.75202702
11MP0002102_abnormal_ear_morphology2.71639468
12MP0005670_abnormal_white_adipose2.59807842
13MP0000653_abnormal_sex_gland2.49860662
14MP0009697_abnormal_copulation2.23827159
15MP0005646_abnormal_pituitary_gland2.18160038
16MP0006072_abnormal_retinal_apoptosis2.15182551
17MP0008872_abnormal_physiological_respon2.08930467
18MP0004233_abnormal_muscle_weight2.08046443
19MP0001661_extended_life_span2.07436859
20MP0004885_abnormal_endolymph2.06347024
21MP0002139_abnormal_hepatobiliary_system2.05591806
22MP0001986_abnormal_taste_sensitivity2.01010563
23MP0005410_abnormal_fertilization13.0139857
24MP0002876_abnormal_thyroid_physiology1.99945639
25MP0005551_abnormal_eye_electrophysiolog1.97560457
26MP0003283_abnormal_digestive_organ1.96407682
27MP0005365_abnormal_bile_salt1.93380591
28MP0004147_increased_porphyrin_level1.84974292
29MP0002837_dystrophic_cardiac_calcinosis1.84639419
30MP0002736_abnormal_nociception_after1.80937848
31MP0002160_abnormal_reproductive_system1.77932736
32MP0001968_abnormal_touch/_nociception1.75870185
33MP0003693_abnormal_embryo_hatching1.75319809
34MP0005075_abnormal_melanosome_morpholog1.75185266
35MP0000751_myopathy1.71920891
36MP0005360_urolithiasis1.68728852
37MP0005645_abnormal_hypothalamus_physiol1.64571915
38MP0003787_abnormal_imprinting1.62850129
39MP0005671_abnormal_response_to1.54188830
40MP0004130_abnormal_muscle_cell1.52167239
41MP0004036_abnormal_muscle_relaxation1.47626095
42MP0008057_abnormal_DNA_replication1.45197126
43MP0000749_muscle_degeneration1.40400797
44MP0002269_muscular_atrophy1.38372157
45MP0005085_abnormal_gallbladder_physiolo1.38275993
46MP0003011_delayed_dark_adaptation1.36739728
47MP0003119_abnormal_digestive_system1.33167354
48MP0005253_abnormal_eye_physiology1.32229451
49MP0002163_abnormal_gland_morphology1.31584563
50MP0005647_abnormal_sex_gland1.31457035
51MP0004145_abnormal_muscle_electrophysio1.31295178
52MP0002138_abnormal_hepatobiliary_system1.28438549
53MP0006036_abnormal_mitochondrial_physio1.25287210
54MP0008775_abnormal_heart_ventricle1.22919285
55MP0005666_abnormal_adipose_tissue1.21344864
56MP0000372_irregular_coat_pigmentation1.20129863
57MP0000631_abnormal_neuroendocrine_gland1.19135899
58MP0001485_abnormal_pinna_reflex1.18579510
59MP0005623_abnormal_meninges_morphology1.18565787
60MP0000427_abnormal_hair_cycle1.16198821
61MP0010094_abnormal_chromosome_stability1.15772041
62MP0004084_abnormal_cardiac_muscle1.14067087
63MP0003786_premature_aging1.13429383
64MP0009046_muscle_twitch1.09382161
65MP0008875_abnormal_xenobiotic_pharmacok1.08794966
66MP0004087_abnormal_muscle_fiber1.08402189
67MP0002938_white_spotting1.06185115
68MP0001919_abnormal_reproductive_system1.04742583
69MP0005220_abnormal_exocrine_pancreas1.04074541
70MP0002009_preneoplasia1.01780083
71MP0002638_abnormal_pupillary_reflex0.99561117
72MP0005451_abnormal_body_composition0.98769029
73MP0006276_abnormal_autonomic_nervous0.98208921
74MP0005379_endocrine/exocrine_gland_phen0.93430471
75MP0003763_abnormal_thymus_physiology0.91760183
76MP0003252_abnormal_bile_duct0.91640650
77MP0001765_abnormal_ion_homeostasis0.91635698
78MP0003718_maternal_effect0.89919555
79MP0005174_abnormal_tail_pigmentation0.89874079
80MP0004142_abnormal_muscle_tone0.89088346
81MP0002272_abnormal_nervous_system0.88748951
82MP0009745_abnormal_behavioral_response0.87606334
83MP0008961_abnormal_basal_metabolism0.86011312
84MP0004215_abnormal_myocardial_fiber0.84471519
85MP0005389_reproductive_system_phenotype0.84134577
86MP0010386_abnormal_urinary_bladder0.84105853
87MP0002106_abnormal_muscle_physiology0.83502780
88MP0002971_abnormal_brown_adipose0.82431276
89MP0008789_abnormal_olfactory_epithelium0.81477824
90MP0000383_abnormal_hair_follicle0.81437772
91MP0004742_abnormal_vestibular_system0.80000334
92MP0001486_abnormal_startle_reflex0.79955505
93MP0001873_stomach_inflammation0.79196676
94MP0009780_abnormal_chondrocyte_physiolo0.78769518
95MP0001963_abnormal_hearing_physiology0.78296881
96MP0003699_abnormal_female_reproductive0.77688997
97MP0005084_abnormal_gallbladder_morpholo0.77622352
98MP0000358_abnormal_cell_content/0.77047883
99MP0000049_abnormal_middle_ear0.76991099
100MP0001984_abnormal_olfaction0.76966502
101MP0005330_cardiomyopathy0.76512271
102MP0002282_abnormal_trachea_morphology0.74475012
103MP0001501_abnormal_sleep_pattern0.73143714
104MP0004043_abnormal_pH_regulation0.72936559
105MP0010329_abnormal_lipoprotein_level0.72160804
106MP0003329_amyloid_beta_deposits0.72086266
107MP0001293_anophthalmia0.72076543
108MP0008007_abnormal_cellular_replicative0.71817056
109MP0002006_tumorigenesis0.71733293
110MP0002234_abnormal_pharynx_morphology0.71484894
111MP0005332_abnormal_amino_acid0.68852895
112MP0003656_abnormal_erythrocyte_physiolo0.67711246
113MP0000759_abnormal_skeletal_muscle0.67551580
114MP0003567_abnormal_fetal_cardiomyocyte0.67335173
115MP0008058_abnormal_DNA_repair0.67189287
116MP0005620_abnormal_muscle_contractility0.66364920
117MP0003111_abnormal_nucleus_morphology0.65599948
118MP0000230_abnormal_systemic_arterial0.65570833
119MP0000569_abnormal_digit_pigmentation0.65519069
120MP0003937_abnormal_limbs/digits/tail_de0.65164237
121MP0005266_abnormal_metabolism0.64734432
122MP0002735_abnormal_chemical_nociception0.64384854
123MP0003938_abnormal_ear_development0.63972195
124MP0002118_abnormal_lipid_homeostasis0.63266566
125MP0003806_abnormal_nucleotide_metabolis0.62769982
126MP0005167_abnormal_blood-brain_barrier0.62737825
127MP0005083_abnormal_biliary_tract0.62318526
128MP0010630_abnormal_cardiac_muscle0.59397251
129MP0006035_abnormal_mitochondrial_morpho0.57293701
130MP0001119_abnormal_female_reproductive0.56395258
131MP0005375_adipose_tissue_phenotype0.55603255
132MP0004264_abnormal_extraembryonic_tissu0.55477504
133MP0001764_abnormal_homeostasis0.55256783
134MP0000609_abnormal_liver_physiology0.54244933
135MP0005319_abnormal_enzyme/_coenzyme0.53338943
136MP0005369_muscle_phenotype0.53337353
137MP0002078_abnormal_glucose_homeostasis0.52904106
138MP0001730_embryonic_growth_arrest0.52397221
139MP0005636_abnormal_mineral_homeostasis0.51310980
140MP0005584_abnormal_enzyme/coenzyme_acti0.50179121
141MP0010307_abnormal_tumor_latency0.48383106
142MP0000747_muscle_weakness0.48372264
143MP0006138_congestive_heart_failure0.47107742
144MP0009115_abnormal_fat_cell0.44438653
145MP0003115_abnormal_respiratory_system0.43362787
146MP0003137_abnormal_impulse_conducting0.41378740
147MP0005076_abnormal_cell_differentiation0.40452382
148MP0005535_abnormal_body_temperature0.40439512
149MP0005397_hematopoietic_system_phenotyp0.40172807
150MP0001545_abnormal_hematopoietic_system0.40172807
151MP0003077_abnormal_cell_cycle0.40090177
152MP0002972_abnormal_cardiac_muscle0.39504783
153MP0002909_abnormal_adrenal_gland0.38496466
154MP0000750_abnormal_muscle_regeneration0.37420053
155MP0001544_abnormal_cardiovascular_syste0.37105099
156MP0005385_cardiovascular_system_phenoty0.37105099
157MP0004085_abnormal_heartbeat0.34597460
158MP0000604_amyloidosis0.34558714
159MP0002693_abnormal_pancreas_physiology0.34352422
160MP0004019_abnormal_vitamin_homeostasis0.33258343
161MP0008995_early_reproductive_senescence0.33019650
162MP0002970_abnormal_white_adipose0.32447849
163MP0003953_abnormal_hormone_level0.31790649
164MP0002254_reproductive_system_inflammat0.31108892

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.22146289
2Abnormal respiratory motile cilium morphology (HP:0005938)7.48856083
3Abnormal respiratory epithelium morphology (HP:0012253)7.48856083
4Rhinitis (HP:0012384)7.17723815
5Chronic bronchitis (HP:0004469)6.73215875
6Nasal polyposis (HP:0100582)6.38601337
7Infertility (HP:0000789)6.34660536
8Abnormal ciliary motility (HP:0012262)6.17473420
9Abnormality of the nasal mucosa (HP:0000433)5.17471687
10Bronchitis (HP:0012387)4.19048609
11Bronchiectasis (HP:0002110)4.17598484
12Abnormality of the lower motor neuron (HP:0002366)4.09920250
13Renal cortical cysts (HP:0000803)4.03004891
14Nephronophthisis (HP:0000090)3.95572208
15Pancreatic cysts (HP:0001737)3.50762520
16Bilateral microphthalmos (HP:0007633)3.44344714
17Male infertility (HP:0003251)3.44080185
18Congenital stationary night blindness (HP:0007642)3.32250210
19Gonadotropin excess (HP:0000837)3.23281356
20Exercise-induced myalgia (HP:0003738)3.14112450
21Tubulointerstitial nephritis (HP:0001970)3.13615296
22Fibular aplasia (HP:0002990)3.13247052
23Abnormality of alanine metabolism (HP:0010916)3.00588211
24Hyperalaninemia (HP:0003348)3.00588211
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.00588211
26IgG deficiency (HP:0004315)3.00410453
27Abnormal spermatogenesis (HP:0008669)2.95555389
28Recurrent otitis media (HP:0000403)2.87450314
29Abnormality of the renal medulla (HP:0100957)2.87174152
30Pancreatic fibrosis (HP:0100732)2.81605438
31Hypoplasia of the fovea (HP:0007750)2.79253390
32Aplasia/Hypoplasia of the fovea (HP:0008060)2.79253390
33Amyotrophic lateral sclerosis (HP:0007354)2.77423210
34Recurrent sinusitis (HP:0011108)2.73652247
35Progressive inability to walk (HP:0002505)2.72210557
36Myoglobinuria (HP:0002913)2.68243685
37Hyperglycinuria (HP:0003108)2.65269211
38Colon cancer (HP:0003003)2.64529226
39Abnormality of serine family amino acid metabolism (HP:0010894)2.58943647
40Abnormality of glycine metabolism (HP:0010895)2.58943647
41Attenuation of retinal blood vessels (HP:0007843)2.58491553
42Impulsivity (HP:0100710)2.57654772
43Exercise-induced muscle cramps (HP:0003710)2.55426963
44Hyperglycinemia (HP:0002154)2.55203857
45Tubulointerstitial abnormality (HP:0001969)2.52768621
46Impaired proprioception (HP:0010831)2.50877849
47True hermaphroditism (HP:0010459)2.49988635
48Abolished electroretinogram (ERG) (HP:0000550)2.49680049
49Recurrent bronchitis (HP:0002837)2.49603765
50Type II lissencephaly (HP:0007260)2.48565566
51Methylmalonic acidemia (HP:0002912)2.48030699
52Prostate neoplasm (HP:0100787)2.47711168
53Cholecystitis (HP:0001082)2.47451967
54Abnormal gallbladder physiology (HP:0012438)2.47451967
55Azoospermia (HP:0000027)2.37392667
56Unilateral renal agenesis (HP:0000122)2.35804360
57Partial agenesis of the corpus callosum (HP:0001338)2.35709161
58Abnormality of the fovea (HP:0000493)2.35043135
59Tubular atrophy (HP:0000092)2.34726835
60Upper motor neuron abnormality (HP:0002127)2.34555152
61Hyporeflexia of lower limbs (HP:0002600)2.34363684
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.25968325
63Inability to walk (HP:0002540)2.25769220
64Fused cervical vertebrae (HP:0002949)2.25744552
65Asymmetric septal hypertrophy (HP:0001670)2.25322655
66Abnormality of the renal cortex (HP:0011035)2.24468152
67Abnormality of B cell number (HP:0010975)2.19000624
68Decreased central vision (HP:0007663)2.18586379
69Congenital, generalized hypertrichosis (HP:0004540)2.16305241
70Aplasia/Hypoplasia of the spleen (HP:0010451)2.15399290
71Rhabdomyolysis (HP:0003201)2.14996791
72Severe combined immunodeficiency (HP:0004430)2.14823144
73Chromsome breakage (HP:0040012)2.14241154
74Asplenia (HP:0001746)2.14106842
75Difficulty climbing stairs (HP:0003551)2.12004220
76Abnormal rod and cone electroretinograms (HP:0008323)2.08427248
77Spastic tetraparesis (HP:0001285)2.08279193
78Neoplasm of the adrenal cortex (HP:0100641)2.07438811
79Chromosomal breakage induced by crosslinking agents (HP:0003221)2.06817477
80Clumsiness (HP:0002312)2.06027142
81Stomach cancer (HP:0012126)2.05442556
82Abnormality of serum amino acid levels (HP:0003112)2.04819774
83Increased CSF lactate (HP:0002490)2.03839763
84Bundle branch block (HP:0011710)2.03763906
85Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.02924985
86EMG: neuropathic changes (HP:0003445)2.02588417
87Thyroiditis (HP:0100646)2.01832995
88Aplasia/Hypoplasia of the tibia (HP:0005772)2.01276583
89Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.3336685
90Dynein arm defect of respiratory motile cilia (HP:0012255)10.9450512
91Absent/shortened dynein arms (HP:0200106)10.9450512
92Enlarged kidneys (HP:0000105)1.99888516
93Absent rod-and cone-mediated responses on ERG (HP:0007688)1.97179343
94Fibular hypoplasia (HP:0003038)1.95370948
95Hypoplasia of the pons (HP:0012110)1.92771856
96B lymphocytopenia (HP:0010976)1.92354167
97Calf muscle hypertrophy (HP:0008981)1.92303367
98Absent thumb (HP:0009777)1.91366219
99Abnormality of the renal collecting system (HP:0004742)1.91348535
100Short tibia (HP:0005736)1.91085211
101Methylmalonic aciduria (HP:0012120)1.90640712
102Keratoconus (HP:0000563)1.90606511
103Increased corneal curvature (HP:0100692)1.90606511
104Lipid accumulation in hepatocytes (HP:0006561)1.90280453
105Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89762896
106Increased serum lactate (HP:0002151)1.89604561
107Cystic liver disease (HP:0006706)1.89590184
108Medial flaring of the eyebrow (HP:0010747)1.89433928
109Abnormality of the ileum (HP:0001549)1.89411029
110Abnormality of the phalanges of the 5th finger (HP:0004213)1.89105114
111Difficulty running (HP:0009046)1.88933574
112Abnormality of the proximal phalanges of the hand (HP:0009834)1.86799039
113Tubulointerstitial fibrosis (HP:0005576)1.86760469
114Microglossia (HP:0000171)1.86727917
115Aplasia/Hypoplasia of the uvula (HP:0010293)1.85353029
116Chronic hepatic failure (HP:0100626)1.85349828
117Pendular nystagmus (HP:0012043)1.84657240
118Meckel diverticulum (HP:0002245)1.82075186
119Abnormality of midbrain morphology (HP:0002418)1.81957912
120Molar tooth sign on MRI (HP:0002419)1.81957912
121Abnormality of the pons (HP:0007361)1.81364071
122Abnormality of the prostate (HP:0008775)1.80850611
123Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78889726
124Abnormality of the labia minora (HP:0012880)1.78499242
125Aplasia/Hypoplasia of the fibula (HP:0006492)1.78328435
126Ketoacidosis (HP:0001993)1.77599636
127Tachypnea (HP:0002789)1.77170839
128Muscle hypertrophy of the lower extremities (HP:0008968)1.76304691
129Absent phalangeal crease (HP:0006109)1.76232878
130Heterotopia (HP:0002282)1.75664331
131Abnormal biliary tract physiology (HP:0012439)1.75576348
132Bile duct proliferation (HP:0001408)1.75576348
133Stage 5 chronic kidney disease (HP:0003774)1.74881775
134Large for gestational age (HP:0001520)1.72390297
135Postaxial foot polydactyly (HP:0001830)1.72036590
136Abnormality of DNA repair (HP:0003254)1.71932267
137Mitochondrial inheritance (HP:0001427)1.71790233
138Abnormality of chromosome stability (HP:0003220)1.71734235
139Bell-shaped thorax (HP:0001591)1.71494301
140J-shaped sella turcica (HP:0002680)1.69984250
141Abnormality of dentin (HP:0010299)1.69273776
142Hepatic necrosis (HP:0002605)1.68066349
143Birth length less than 3rd percentile (HP:0003561)1.67930793
144Brittle hair (HP:0002299)1.67343091
145Oligohydramnios (HP:0001562)1.65929348
146Renal dysplasia (HP:0000110)1.65714366
147Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.65315779
148Abnormal drinking behavior (HP:0030082)1.65254895
149Polydipsia (HP:0001959)1.65254895
150Cerebellar dysplasia (HP:0007033)1.64900705
151Duplicated collecting system (HP:0000081)1.64899748
152Sloping forehead (HP:0000340)1.64876205
153Decreased circulating renin level (HP:0003351)1.64871283
154Breast carcinoma (HP:0003002)1.61628342
155Congenital hepatic fibrosis (HP:0002612)1.60488794
156Decreased motor nerve conduction velocity (HP:0003431)1.59663548
157Abnormality of ocular smooth pursuit (HP:0000617)1.59395222
158Impaired vibratory sensation (HP:0002495)1.59341669
159Short ribs (HP:0000773)1.59207193
160Sudden death (HP:0001699)1.58013073
161Ketosis (HP:0001946)1.56037320
162Impaired vibration sensation in the lower limbs (HP:0002166)1.52231731
163Absent frontal sinuses (HP:0002688)1.49154570
164Short thorax (HP:0010306)1.48500853
165Hypoalphalipoproteinemia (HP:0003233)1.46844266
166Pachygyria (HP:0001302)1.44377737
167Oculomotor apraxia (HP:0000657)1.43967507
168Global brain atrophy (HP:0002283)1.42124418
169Broad distal phalanx of finger (HP:0009836)1.38719319
170Dysmetric saccades (HP:0000641)1.37903638
171Deformed sella turcica (HP:0002681)1.37520542
172Difficulty walking (HP:0002355)1.37239420
173Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.31690744
174Abnormality of renal excretion (HP:0011036)1.31220560
175Retinal atrophy (HP:0001105)1.30246359
176Abnormality of the dental root (HP:0006486)1.30078626
177Taurodontia (HP:0000679)1.30078626
178Abnormality of permanent molar morphology (HP:0011071)1.30078626
179Chronic sinusitis (HP:0011109)1.29789374
180Fatigable weakness (HP:0003473)1.29312944
181Abnormality of the neuromuscular junction (HP:0003398)1.29312944
182Easy fatigability (HP:0003388)1.28781919
183Degeneration of anterior horn cells (HP:0002398)1.28586337
184Abnormality of the anterior horn cell (HP:0006802)1.28586337
185Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.28405343
186Gaze-evoked nystagmus (HP:0000640)1.25099642
187Heart block (HP:0012722)1.25094063
188Absent epiphyses (HP:0010577)1.24880481
189Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.24880481

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.45923641
2PDK48.45923641
3PDK25.31731580
4PRKD34.60432695
5TESK14.24842717
6TXK3.79999905
7FRK3.72375299
8ZAK3.55256459
9NUAK13.37870460
10TLK12.84778458
11MAP4K22.82408379
12ICK2.80914080
13VRK22.53392257
14GRK12.17788865
15ADRBK22.16513558
16ACVR1B2.15656758
17TAF12.03052206
18NEK21.97036668
19STK381.92622158
20WNK41.89098542
21PTK2B1.77330185
22EEF2K1.57950039
23INSRR1.52158075
24PNCK1.51447565
25PLK41.44590496
26VRK11.38589670
27STK391.38359764
28TRIB31.32550990
29PASK1.21612979
30BUB11.21289996
31MST41.19362771
32MUSK1.13117690
33MAP2K21.11853341
34MAP4K11.11274545
35OXSR11.08919714
36PLK31.05258059
37PDK10.99791092
38DYRK30.98591311
39EIF2AK20.93606543
40MKNK20.93455217
41OBSCN0.93349303
42MAPK130.93001182
43EIF2AK30.92304678
44STK30.91145004
45TTK0.89568200
46SRPK10.88038914
47CDC70.87918931
48BCKDK0.87331596
49PINK10.85098887
50TTN0.84828252
51DYRK1B0.84573445
52MAP3K60.82659338
53CDK80.81615797
54MAP3K40.80593883
55WNK10.80007886
56CSNK1G30.79884265
57TEC0.79346885
58GRK50.79292637
59KDR0.79156744
60ERBB30.78065234
61NME10.76946694
62CSNK1G10.76387548
63STK38L0.75774698
64KIT0.75433554
65CSNK1G20.73230499
66TIE10.72218936
67MKNK10.70652041
68ITK0.70062604
69MAPKAPK30.69901603
70DAPK20.69113175
71PRKCQ0.68607853
72GRK60.65723070
73IKBKB0.64302231
74SYK0.63456302
75CAMK1G0.62080547
76TYRO30.61011308
77LMTK20.60812087
78PRKAA10.60762586
79BMPR20.60267216
80PHKG20.59821722
81PHKG10.59821722
82PIK3CA0.59678381
83STK160.59527919
84PRKCI0.56584327
85MAP2K40.56402157
86DYRK20.55553618
87PLK20.54815453
88PRKCE0.52497056
89TRIM280.51845266
90CSNK1A1L0.51381844
91TAOK10.51150132
92RPS6KA50.50782874
93CHEK20.50377044
94NEK10.50292559
95MELK0.49692835
96RIPK10.49530026
97ADRBK10.48996077
98DAPK10.48774400
99BRSK20.48762707
100PKN20.48291464
101MAPK150.47813504
102TESK20.47134629
103ATR0.46944657
104TGFBR10.45718048
105CHEK10.45656205
106PDPK10.44784913
107MARK30.43783040
108CCNB10.43710695
109LATS10.43300193
110PAK60.42843111
111CAMKK10.42132208
112ATM0.41533371
113AURKB0.41284800
114PRKAA20.41110914
115MAP2K10.40548953
116IGF1R0.40442008
117MAP2K70.39796611
118FES0.39438844
119TRPM70.39166693
120LATS20.38610774
121HIPK20.38301666
122MTOR0.36574527
123MAP2K60.35831864
124FLT30.34991220
125CDK120.34750827
126CSNK2A10.34289153
127MAPK110.34065593
128DMPK0.33844652
129NTRK20.32775655
130MAP3K50.32598002
131MAPKAPK50.31197210
132RPS6KB10.30770480
133CSNK1A10.30669070
134CSNK1D0.29339971
135PLK10.27389190
136TAOK30.25193948
137BRSK10.23454802
138MARK20.21790131
139RPS6KA20.21175335
140ERBB40.19615126
141RPS6KA40.19212980
142MAP3K100.16368971
143PAK20.15747945
144STK110.15666687
145SIK10.15455555
146BMPR1B0.15297477
147MAP2K30.14457548
148RPS6KA10.14338688
149CDK40.14057401
150PAK10.13496149
151RET0.12515646
152WEE10.10967032
153CDK10.09865786
154MAP3K70.09636323
155PRKCG0.08754003
156PRKDC0.08319128
157MAPK100.07541633
158WNK30.07521483
159RPS6KA30.07290674
160CDK20.06525746
161PTK60.06251342
162PRKACG0.05070412
163GSK3B0.04156424
164PIK3CG0.03955829
165PRKACB0.03947481
166CDK150.03925306
167MAPK120.03806856
168PRKCH0.03186764
169JAK20.02948769

Predicted pathways (KEGG)

RankGene SetZ-score
1Pyruvate metabolism_Homo sapiens_hsa006203.90304272
2Propanoate metabolism_Homo sapiens_hsa006403.87670756
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.61132019
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.18883562
5Vitamin B6 metabolism_Homo sapiens_hsa007503.11537118
6Fatty acid biosynthesis_Homo sapiens_hsa000612.80098453
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.78082338
8Homologous recombination_Homo sapiens_hsa034402.69936872
9Glucagon signaling pathway_Homo sapiens_hsa049222.61941560
10Selenocompound metabolism_Homo sapiens_hsa004502.57564951
11Fatty acid degradation_Homo sapiens_hsa000712.51013595
12One carbon pool by folate_Homo sapiens_hsa006702.26947535
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.23230862
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17049750
15Mismatch repair_Homo sapiens_hsa034302.13072563
16Phototransduction_Homo sapiens_hsa047442.12577806
17Carbon metabolism_Homo sapiens_hsa012002.12206472
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.12128985
19Fatty acid metabolism_Homo sapiens_hsa012122.11920040
20DNA replication_Homo sapiens_hsa030302.06228764
21RNA polymerase_Homo sapiens_hsa030202.00315751
22Non-homologous end-joining_Homo sapiens_hsa034501.98661552
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95362523
24Primary immunodeficiency_Homo sapiens_hsa053401.93622750
25PPAR signaling pathway_Homo sapiens_hsa033201.92859504
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.84975960
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.83643319
28Dorso-ventral axis formation_Homo sapiens_hsa043201.79846804
29* RNA degradation_Homo sapiens_hsa030181.79741010
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.79017909
31Pentose phosphate pathway_Homo sapiens_hsa000301.75804555
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.72566985
33Caffeine metabolism_Homo sapiens_hsa002321.71707034
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.71461390
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62750250
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62093705
37Linoleic acid metabolism_Homo sapiens_hsa005911.60685573
38Glycerolipid metabolism_Homo sapiens_hsa005611.55888154
39Biosynthesis of amino acids_Homo sapiens_hsa012301.49626054
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45347295
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.43977617
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43760094
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36705158
44Oocyte meiosis_Homo sapiens_hsa041141.35959924
45Olfactory transduction_Homo sapiens_hsa047401.33932835
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.31087323
47Cardiac muscle contraction_Homo sapiens_hsa042601.30464542
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.30075337
49Nucleotide excision repair_Homo sapiens_hsa034201.28923195
50Proteasome_Homo sapiens_hsa030501.27200021
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25934191
52Pyrimidine metabolism_Homo sapiens_hsa002401.21788031
53Base excision repair_Homo sapiens_hsa034101.20887586
54ABC transporters_Homo sapiens_hsa020101.20466859
55Primary bile acid biosynthesis_Homo sapiens_hsa001201.17185042
56Fructose and mannose metabolism_Homo sapiens_hsa000511.17138627
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.16533911
58Protein export_Homo sapiens_hsa030601.15632794
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14407000
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13593964
61Basal transcription factors_Homo sapiens_hsa030221.13026045
62Amphetamine addiction_Homo sapiens_hsa050311.09004407
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07475499
64Fanconi anemia pathway_Homo sapiens_hsa034601.06747773
65Intestinal immune network for IgA production_Homo sapiens_hsa046721.05752405
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03984800
67Nitrogen metabolism_Homo sapiens_hsa009101.03773021
68Oxidative phosphorylation_Homo sapiens_hsa001901.01053552
69Nicotine addiction_Homo sapiens_hsa050331.00250746
70Bile secretion_Homo sapiens_hsa049760.97277411
71Renin secretion_Homo sapiens_hsa049240.96716668
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94774574
73Butanoate metabolism_Homo sapiens_hsa006500.93340978
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.93182726
75Regulation of autophagy_Homo sapiens_hsa041400.92865741
76Parkinsons disease_Homo sapiens_hsa050120.92521982
77Fat digestion and absorption_Homo sapiens_hsa049750.90903204
78Huntingtons disease_Homo sapiens_hsa050160.89574626
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88860150
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88440025
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86867089
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86256958
83Starch and sucrose metabolism_Homo sapiens_hsa005000.85592010
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84587053
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84002937
86Arginine biosynthesis_Homo sapiens_hsa002200.82718776
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82552902
88Peroxisome_Homo sapiens_hsa041460.82502044
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.81191437
90Tryptophan metabolism_Homo sapiens_hsa003800.80653542
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.79367003
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74316473
93Lysine degradation_Homo sapiens_hsa003100.73292422
94mRNA surveillance pathway_Homo sapiens_hsa030150.72176377
95Arachidonic acid metabolism_Homo sapiens_hsa005900.72078562
96AMPK signaling pathway_Homo sapiens_hsa041520.70217455
97Long-term potentiation_Homo sapiens_hsa047200.69090945
98Insulin secretion_Homo sapiens_hsa049110.69063685
99Insulin resistance_Homo sapiens_hsa049310.68941659
100Type II diabetes mellitus_Homo sapiens_hsa049300.64733014
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63686207
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63327585
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62071506
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61986858
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61832943
106Ribosome_Homo sapiens_hsa030100.60837309
107Chemical carcinogenesis_Homo sapiens_hsa052040.60782522
108Antigen processing and presentation_Homo sapiens_hsa046120.59997920
109Spliceosome_Homo sapiens_hsa030400.58066729
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56196473
111Morphine addiction_Homo sapiens_hsa050320.55890981
112beta-Alanine metabolism_Homo sapiens_hsa004100.53410243
113Insulin signaling pathway_Homo sapiens_hsa049100.53300296
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53132351
115Circadian entrainment_Homo sapiens_hsa047130.52952433
116Ether lipid metabolism_Homo sapiens_hsa005650.52666823
117Graft-versus-host disease_Homo sapiens_hsa053320.52261805
118Estrogen signaling pathway_Homo sapiens_hsa049150.52115497
119Histidine metabolism_Homo sapiens_hsa003400.51516282
120Arginine and proline metabolism_Homo sapiens_hsa003300.51494823
121Complement and coagulation cascades_Homo sapiens_hsa046100.51381885
122Salivary secretion_Homo sapiens_hsa049700.49929482
123RNA transport_Homo sapiens_hsa030130.46895006
124Alzheimers disease_Homo sapiens_hsa050100.46373210
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44663479
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43329887
127Calcium signaling pathway_Homo sapiens_hsa040200.43181040
128Fatty acid elongation_Homo sapiens_hsa000620.42456215
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41525350
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41380246
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.41235690
132Thyroid hormone synthesis_Homo sapiens_hsa049180.40933614
133Inositol phosphate metabolism_Homo sapiens_hsa005620.40555098
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40392604
135Tyrosine metabolism_Homo sapiens_hsa003500.40113980
136p53 signaling pathway_Homo sapiens_hsa041150.39140786
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38548636
138Dilated cardiomyopathy_Homo sapiens_hsa054140.38118775
139Glutathione metabolism_Homo sapiens_hsa004800.37640181
140Galactose metabolism_Homo sapiens_hsa000520.37467607
141Circadian rhythm_Homo sapiens_hsa047100.36159270
142Retinol metabolism_Homo sapiens_hsa008300.35290476
143Sulfur relay system_Homo sapiens_hsa041220.35087170
144Vitamin digestion and absorption_Homo sapiens_hsa049770.34081015
145Cyanoamino acid metabolism_Homo sapiens_hsa004600.33771123
146Cell cycle_Homo sapiens_hsa041100.33768067
147Ovarian steroidogenesis_Homo sapiens_hsa049130.32892216
148Sulfur metabolism_Homo sapiens_hsa009200.32882225
149Metabolic pathways_Homo sapiens_hsa011000.31522961
150Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30551121
151Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30300627
152Vascular smooth muscle contraction_Homo sapiens_hsa042700.26181260
153Taste transduction_Homo sapiens_hsa047420.25008734
154Purine metabolism_Homo sapiens_hsa002300.24385534

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