DIS3L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1replication fork processing (GO:0031297)8.62663064
2transcription from mitochondrial promoter (GO:0006390)7.75581138
3proline metabolic process (GO:0006560)7.73532264
4negative regulation of cytosolic calcium ion concentration (GO:0051481)7.61695304
5embryonic process involved in female pregnancy (GO:0060136)6.90955227
6maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.88748927
7oxidative demethylation (GO:0070989)6.83963235
8negative regulation of cAMP-mediated signaling (GO:0043951)6.41204226
9positive regulation of protein homooligomerization (GO:0032464)6.33363875
10DNA strand renaturation (GO:0000733)6.15825702
11behavioral response to ethanol (GO:0048149)5.68202145
12DNA deamination (GO:0045006)5.66122325
13regulation of protein homooligomerization (GO:0032462)5.53433304
14regulation of integrin activation (GO:0033623)5.45709330
15somatic diversification of immune receptors via somatic mutation (GO:0002566)5.27789660
16somatic hypermutation of immunoglobulin genes (GO:0016446)5.27789660
17regulation of translational fidelity (GO:0006450)5.26460363
18establishment of apical/basal cell polarity (GO:0035089)5.22214436
19viral mRNA export from host cell nucleus (GO:0046784)5.15265170
20poly(A)+ mRNA export from nucleus (GO:0016973)5.14927093
21positive regulation of developmental pigmentation (GO:0048087)5.04176105
22mitochondrial DNA metabolic process (GO:0032042)4.93972244
23negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.88459889
24negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.85665361
25establishment of monopolar cell polarity (GO:0061162)4.80004558
26establishment or maintenance of monopolar cell polarity (GO:0061339)4.80004558
27epithelial cilium movement (GO:0003351)4.76713270
28piRNA metabolic process (GO:0034587)4.73544460
29protein polyglutamylation (GO:0018095)4.63175281
30dosage compensation (GO:0007549)4.60877043
31opioid receptor signaling pathway (GO:0038003)4.55909862
32negative regulation of JAK-STAT cascade (GO:0046426)4.44909861
33mRNA cleavage (GO:0006379)4.44277735
34negative regulation of cell cycle arrest (GO:0071157)4.39254587
35negative regulation of mRNA processing (GO:0050686)4.38641885
36base-excision repair (GO:0006284)4.37740298
37axoneme assembly (GO:0035082)4.32057078
38spliceosomal tri-snRNP complex assembly (GO:0000244)4.30338999
39pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.25554328
40cilium movement (GO:0003341)4.25530940
41DNA integration (GO:0015074)4.23170564
42non-recombinational repair (GO:0000726)4.22888042
43double-strand break repair via nonhomologous end joining (GO:0006303)4.22888042
44establishment of protein localization to Golgi (GO:0072600)4.18293701
45convergent extension (GO:0060026)4.17145571
46cilium or flagellum-dependent cell motility (GO:0001539)4.17000221
47regulation of acrosome reaction (GO:0060046)4.14711997
48DNA demethylation (GO:0080111)4.13964805
49cellular response to zinc ion (GO:0071294)4.12272303
50DNA replication-dependent nucleosome assembly (GO:0006335)4.04103600
51DNA replication-dependent nucleosome organization (GO:0034723)4.04103600
52DNA double-strand break processing (GO:0000729)3.99108982
53positive regulation by host of viral transcription (GO:0043923)3.98889358
54base-excision repair, AP site formation (GO:0006285)3.98368076
55embryonic placenta development (GO:0001892)3.96037625
56adult feeding behavior (GO:0008343)3.95387337
57DNA ligation (GO:0006266)3.90768143
58mitotic G1 DNA damage checkpoint (GO:0031571)3.89874852
59regulation of RNA export from nucleus (GO:0046831)3.89837132
60regulation of cilium movement (GO:0003352)3.86012489
61glutamine family amino acid biosynthetic process (GO:0009084)3.83472515
62negative regulation of RNA splicing (GO:0033119)3.82128337
63telomere maintenance via semi-conservative replication (GO:0032201)3.81878171
64cellular response to ATP (GO:0071318)3.79948474
65nucleotide-excision repair, DNA gap filling (GO:0006297)3.72774036
66embryonic camera-type eye development (GO:0031076)3.72531897
67protein targeting to Golgi (GO:0000042)3.72013258
68histone H3-K9 modification (GO:0061647)3.70676865
69regulation of translational termination (GO:0006449)3.70321970
70negative regulation of protein oligomerization (GO:0032460)3.68243050
71positive regulation of protein oligomerization (GO:0032461)3.67640464
72termination of RNA polymerase II transcription (GO:0006369)3.63328731
73histone H3-K9 methylation (GO:0051567)3.61940026
74mitochondrial RNA metabolic process (GO:0000959)3.61626130
75apoptotic process involved in morphogenesis (GO:0060561)3.58820360
76DNA topological change (GO:0006265)3.56732521
77regulation of protein oligomerization (GO:0032459)3.55183347
78pyrimidine nucleotide catabolic process (GO:0006244)3.53099479
79negative regulation of mRNA metabolic process (GO:1903312)3.52875362
80histone H4-K12 acetylation (GO:0043983)3.52420232
81regulation of cAMP-dependent protein kinase activity (GO:2000479)3.46459240
82negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.43960912
83G1 DNA damage checkpoint (GO:0044783)3.43772148
84protein K11-linked deubiquitination (GO:0035871)3.42718401
85activation of Rac GTPase activity (GO:0032863)3.41533940
86regulation of sister chromatid cohesion (GO:0007063)3.39987855
87retrograde transport, vesicle recycling within Golgi (GO:0000301)3.39466682
88positive regulation of mitotic sister chromatid separation (GO:1901970)3.37576165
89positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.37576165
90positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.37576165
91regulation of mitochondrial depolarization (GO:0051900)3.37271470
92photoreceptor cell maintenance (GO:0045494)3.35195033
93mitotic G1/S transition checkpoint (GO:0044819)3.34522900
94negative regulation of viral release from host cell (GO:1902187)3.33536219
95cell migration in hindbrain (GO:0021535)3.32512027
96snRNA transcription (GO:0009301)3.32017137
97sperm motility (GO:0030317)3.30197710
98positive regulation of DNA repair (GO:0045739)3.29030318
99ketone body metabolic process (GO:1902224)3.29014552
100cellular ketone body metabolic process (GO:0046950)3.27911110
101negative regulation of Ras GTPase activity (GO:0034261)3.27332621
102spermatid development (GO:0007286)3.26521940
103protein targeting to lysosome (GO:0006622)3.24891068
104establishment of protein localization to vacuole (GO:0072666)3.24891068
105protein targeting to vacuole (GO:0006623)3.24891068
106DNA strand elongation involved in DNA replication (GO:0006271)3.24410228
107cullin deneddylation (GO:0010388)3.24290326
108telomere maintenance via recombination (GO:0000722)3.24161250
109protein localization to Golgi apparatus (GO:0034067)3.23932262
110face development (GO:0060324)3.23191548
111ether lipid metabolic process (GO:0046485)3.22791443
112behavioral response to nicotine (GO:0035095)3.22256677
113mRNA polyadenylation (GO:0006378)3.20779483
114regulation of DNA damage checkpoint (GO:2000001)3.20089118
115GDP-mannose metabolic process (GO:0019673)3.19851654
116establishment of protein localization to mitochondrial membrane (GO:0090151)3.19153024
117glial cell migration (GO:0008347)3.19113981
118formation of translation preinitiation complex (GO:0001731)3.18696257
119negative regulation of heart rate (GO:0010459)3.18403828
120regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.17955942
121regulation of cell size (GO:0008361)3.17831576
122glycerol ether metabolic process (GO:0006662)3.16483246
123synaptic vesicle endocytosis (GO:0048488)3.14979824
124coenzyme catabolic process (GO:0009109)3.12920684
125anatomical structure regression (GO:0060033)3.11333655
126resolution of meiotic recombination intermediates (GO:0000712)3.11326920
127positive regulation of dendritic spine morphogenesis (GO:0061003)3.10216119
128DNA strand elongation (GO:0022616)3.09513338
129regulation of protein glycosylation (GO:0060049)3.09261655
130epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.09155850
131N-terminal protein amino acid acetylation (GO:0006474)3.08489079
132cilium morphogenesis (GO:0060271)3.07887020
133positive regulation of receptor recycling (GO:0001921)3.06671069
134positive regulation of circadian rhythm (GO:0042753)3.05185312
135sphingosine metabolic process (GO:0006670)3.03592783
136gene silencing by RNA (GO:0031047)3.02757389
137protein K48-linked deubiquitination (GO:0071108)3.01042282
138positive regulation of cAMP-mediated signaling (GO:0043950)2.95345147
139axonemal dynein complex assembly (GO:0070286)2.93739985
140neural tube formation (GO:0001841)2.93288437
141acrosome reaction (GO:0007340)2.86065661
142motile cilium assembly (GO:0044458)2.85973170
143regulation of hippo signaling (GO:0035330)2.85167567
144microtubule severing (GO:0051013)2.84518831
145cornea development in camera-type eye (GO:0061303)2.84387497
146sulfation (GO:0051923)2.81299660
147head development (GO:0060322)2.79211143
148detection of light stimulus involved in sensory perception (GO:0050962)2.77455302
149detection of light stimulus involved in visual perception (GO:0050908)2.77455302
150microtubule nucleation (GO:0007020)2.73478013
151cAMP catabolic process (GO:0006198)2.73355107
152microtubule anchoring (GO:0034453)2.72658563
153monoubiquitinated protein deubiquitination (GO:0035520)2.70997852
154fucose catabolic process (GO:0019317)2.70705782
155L-fucose metabolic process (GO:0042354)2.70705782
156L-fucose catabolic process (GO:0042355)2.70705782
157peptidyl-lysine trimethylation (GO:0018023)2.70284304
158phosphatidylethanolamine biosynthetic process (GO:0006646)2.70091039
159pyrimidine nucleobase catabolic process (GO:0006208)2.70047454
160intraciliary transport (GO:0042073)2.68699431
161sphingoid metabolic process (GO:0046519)2.68670986
162diol metabolic process (GO:0034311)2.66762368
163thyroid hormone generation (GO:0006590)2.66323856
164double-strand break repair via homologous recombination (GO:0000724)2.65162091
165multicellular organism reproduction (GO:0032504)2.64579626
166thyroid hormone metabolic process (GO:0042403)2.64214920
167cilium organization (GO:0044782)2.63961392
168regulation of microtubule-based movement (GO:0060632)2.63491301
169recombinational repair (GO:0000725)2.62521171
170phosphatidylethanolamine metabolic process (GO:0046337)2.61749235
171brain morphogenesis (GO:0048854)2.60648819
172response to pheromone (GO:0019236)2.60359297
173retinal rod cell development (GO:0046548)2.59589191
174peptidyl-lysine methylation (GO:0018022)2.59056162
175cellular response to sterol (GO:0036315)2.58416590
176positive regulation of defense response to virus by host (GO:0002230)2.58312918
177cilium assembly (GO:0042384)2.58080229
178positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.57918726
179protein K63-linked deubiquitination (GO:0070536)2.57725137
180snRNA processing (GO:0016180)2.56469685
181rRNA catabolic process (GO:0016075)2.55998815
182regulation of Rab GTPase activity (GO:0032313)2.52728009
183positive regulation of Rab GTPase activity (GO:0032851)2.52728009
184DNA methylation involved in gamete generation (GO:0043046)2.50506131
185gene silencing (GO:0016458)2.50299397
186fibroblast migration (GO:0010761)2.50122650
187genitalia morphogenesis (GO:0035112)2.47495511
188regulation of telomere maintenance (GO:0032204)2.47254055
189detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.45602460
190positive regulation of oligodendrocyte differentiation (GO:0048714)2.43254369
191negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.42403248
192negative regulation of translation, ncRNA-mediated (GO:0040033)2.42403248
193regulation of translation, ncRNA-mediated (GO:0045974)2.42403248
194adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.41200647
195proline biosynthetic process (GO:0006561)10.2567792

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.30474344
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.07384408
3ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.57906138
4SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.30007061
5GBX2_23144817_ChIP-Seq_PC3_Human3.01596145
6VDR_22108803_ChIP-Seq_LS180_Human2.98592691
7* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.88582035
8VDR_21846776_ChIP-Seq_THP-1_Human2.88040491
9ZNF274_21170338_ChIP-Seq_K562_Hela2.62465824
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.49530490
11E2F7_22180533_ChIP-Seq_HELA_Human2.46479212
12IGF1R_20145208_ChIP-Seq_DFB_Human2.46222954
13DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.44564305
14SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.41558869
15DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.40334987
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39094761
17MYC_22102868_ChIP-Seq_BL_Human2.36133807
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.33550372
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.30453246
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.29521830
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.26904975
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.24638716
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.24638716
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.24638716
25NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.17742800
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17719261
27POU5F1_16518401_ChIP-PET_MESCs_Mouse2.14003372
28TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13316285
29POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.13316285
30PU.1_20513432_ChIP-Seq_Bcells_Mouse2.13029322
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.10845426
32LXR_22292898_ChIP-Seq_THP-1_Human2.09812948
33KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.09217597
34CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.02444797
35TCF3_18692474_ChIP-Seq_MESCs_Mouse2.01580520
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97470767
37RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.97419210
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.97130396
39TAF15_26573619_Chip-Seq_HEK293_Human1.96795226
40CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.96306858
41* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94932249
42NANOG_21062744_ChIP-ChIP_HESCs_Human1.93518611
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.92495494
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.91631289
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.87868986
46* STAT3_23295773_ChIP-Seq_U87_Human1.86718891
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.85631932
48CBP_20019798_ChIP-Seq_JUKART_Human1.82974702
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.82974702
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80264702
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77981713
52RXR_22108803_ChIP-Seq_LS180_Human1.75311728
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.73788066
54IRF1_19129219_ChIP-ChIP_H3396_Human1.71056297
55* TCF4_23295773_ChIP-Seq_U87_Human1.70456636
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.69975478
57DROSHA_22980978_ChIP-Seq_HELA_Human1.68505177
58AR_21572438_ChIP-Seq_LNCaP_Human1.63474462
59FUS_26573619_Chip-Seq_HEK293_Human1.62424868
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.62210752
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.62184149
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61964415
63ER_23166858_ChIP-Seq_MCF-7_Human1.61562509
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61091791
65* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58526537
66CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.56939464
67ZFP281_27345836_Chip-Seq_ESCs_Mouse1.56511118
68BCAT_22108803_ChIP-Seq_LS180_Human1.55562079
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55033269
70* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52675254
71EZH2_22144423_ChIP-Seq_EOC_Human1.51340348
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.50322497
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50106204
74* SMAD4_21799915_ChIP-Seq_A2780_Human1.49424281
75P300_19829295_ChIP-Seq_ESCs_Human1.49023904
76ETS1_21867929_ChIP-Seq_TH2_Mouse1.48077198
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47664833
78NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.47492409
79NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.46404485
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45746938
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45516910
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.43917261
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43912421
84EWS_26573619_Chip-Seq_HEK293_Human1.43118645
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.42923888
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.42701120
87WDR5_24793694_ChIP-Seq_LNCAP_Human1.42102010
88KDM2B_26808549_Chip-Seq_DND41_Human1.41869777
89POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.40850018
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38450878
91SOX2_18555785_ChIP-Seq_MESCs_Mouse1.38179605
92JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37557280
93* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36941081
94HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36680803
95NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.36024203
96* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35599533
97SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34041184
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.33375122
99* FLI1_27457419_Chip-Seq_LIVER_Mouse1.32856169
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.32759843
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32109248
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29843265
103KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28941034
104KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28251847
105* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27127081
106RXRA_24833708_ChIP-Seq_LIVER_Mouse1.26342689
107MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26186661
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25741164
109E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25610246
110STAT1_20625510_ChIP-Seq_HELA_Human1.25478479
111* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.25265791
112RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24348932
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24169320
114RARB_24833708_ChIP-Seq_LIVER_Mouse1.23548352
115TCF3_18692474_ChIP-Seq_MEFs_Mouse1.23489160
116SOX2_18692474_ChIP-Seq_MESCs_Mouse1.21730934
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21438949
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21123174
119SPI1_26923725_Chip-Seq_HPCs_Mouse1.21110653
120* AR_25329375_ChIP-Seq_VCAP_Human1.20983598
121SALL1_21062744_ChIP-ChIP_HESCs_Human1.19798333
122* GABP_19822575_ChIP-Seq_HepG2_Human1.19638769
123MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19553361
124NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18798354
125* SMAD3_21741376_ChIP-Seq_EPCs_Human1.18768136
126PRDM14_20953172_ChIP-Seq_ESCs_Human1.18629243
127RACK7_27058665_Chip-Seq_MCF-7_Human1.17857109
128MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17750215
129SOX2_19829295_ChIP-Seq_ESCs_Human1.16929783
130NANOG_19829295_ChIP-Seq_ESCs_Human1.16929783
131VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16457464
132YY1_22570637_ChIP-Seq_MALME-3M_Human1.16454238
133EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13896661
134PIAS1_25552417_ChIP-Seq_VCAP_Human1.13738540
135PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.13719571
136FOXM1_23109430_ChIP-Seq_U2OS_Human1.13121232
137* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12578272
138FLI1_21867929_ChIP-Seq_TH2_Mouse1.11982712
139KDM5A_27292631_Chip-Seq_BREAST_Human1.11834963
140LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11471862
141FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.11264668
142SOX2_21211035_ChIP-Seq_LN229_Gbm1.10914868
143TCF4_22108803_ChIP-Seq_LS180_Human1.10655008
144NANOG_18692474_ChIP-Seq_MESCs_Mouse1.10099753
145* RUNX2_22187159_ChIP-Seq_PCA_Human1.09811732
146STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09500755
147TP53_16413492_ChIP-PET_HCT116_Human1.08948141
148PHF8_20622854_ChIP-Seq_HELA_Human1.08557909
149PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08420890
150* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08244884
151TTF2_22483619_ChIP-Seq_HELA_Human1.07969688
152E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06916974
153XRN2_22483619_ChIP-Seq_HELA_Human1.06524780
154SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.06089645
155RARA_24833708_ChIP-Seq_LIVER_Mouse1.05746220
156SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05185051
157DCP1A_22483619_ChIP-Seq_HELA_Human1.04785450
158TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.04123935
159ERA_21632823_ChIP-Seq_H3396_Human1.04045947
160CIITA_25753668_ChIP-Seq_RAJI_Human1.03440047
161RUNX_20019798_ChIP-Seq_JUKART_Human1.03396153
162AHR_22903824_ChIP-Seq_MCF-7_Human1.02440022
163E2F1_20622854_ChIP-Seq_HELA_Human1.02380275
164VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01913395
165POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01710640
166TP53_22573176_ChIP-Seq_HFKS_Human1.01221641
167* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01186560
168KDM2B_26808549_Chip-Seq_REH_Human1.01119274
169BCOR_27268052_Chip-Seq_Bcells_Human0.99934567
170HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99905756
171OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99758434
172CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99734713
173CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99145260
174NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98903588
175GATA3_21878914_ChIP-Seq_MCF-7_Human0.97360266
176KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96600088
177MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96169328
178MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95022263
179CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94155341
180TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94006566
181TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93726309
182E2F1_17053090_ChIP-ChIP_MCF-7_Human0.92918472
183* NFE2_27457419_Chip-Seq_LIVER_Mouse0.92575145
184ARNT_22903824_ChIP-Seq_MCF-7_Human0.92514159
185SMAD4_21741376_ChIP-Seq_EPCs_Human0.92478085
186CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92247909
187* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92120255
188AR_19668381_ChIP-Seq_PC3_Human0.89445852
189CDX2_22108803_ChIP-Seq_LS180_Human0.89347963
190TP63_19390658_ChIP-ChIP_HaCaT_Human0.89119410
191FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.88656742
192OCT4_20526341_ChIP-Seq_ESCs_Human0.88286726
193TDRD3_21172665_ChIP-Seq_MCF-7_Human0.87668174
194RAC3_21632823_ChIP-Seq_H3396_Human0.87552295
195* EZH2_27294783_Chip-Seq_NPCs_Mouse0.87091997
196ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86743618

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.63048078
2MP0005171_absent_coat_pigmentation4.58292746
3MP0010030_abnormal_orbit_morphology3.97082521
4MP0004233_abnormal_muscle_weight3.69825870
5MP0009278_abnormal_bone_marrow3.61197145
6MP0005174_abnormal_tail_pigmentation3.31278966
7MP0002009_preneoplasia3.26148629
8MP0002653_abnormal_ependyma_morphology3.11645409
9MP0002876_abnormal_thyroid_physiology2.97162087
10MP0003646_muscle_fatigue2.92609636
11MP0002102_abnormal_ear_morphology2.70274679
12MP0005075_abnormal_melanosome_morpholog2.68503349
13MP0009780_abnormal_chondrocyte_physiolo2.64613545
14MP0003890_abnormal_embryonic-extraembry2.62049881
15MP0003172_abnormal_lysosome_physiology2.58320882
16MP0006072_abnormal_retinal_apoptosis2.52641138
17MP0008995_early_reproductive_senescence2.52259026
18MP0000015_abnormal_ear_pigmentation2.44735471
19MP0010094_abnormal_chromosome_stability2.43993162
20MP0001968_abnormal_touch/_nociception2.42093577
21MP0000372_irregular_coat_pigmentation2.29117109
22MP0005551_abnormal_eye_electrophysiolog2.23470878
23MP0003136_yellow_coat_color2.04688294
24MP0001270_distended_abdomen1.99384576
25MP0008877_abnormal_DNA_methylation1.94254844
26MP0001485_abnormal_pinna_reflex1.92913093
27MP0004742_abnormal_vestibular_system1.91959810
28MP0003763_abnormal_thymus_physiology1.85676186
29MP0000371_diluted_coat_color1.84827366
30MP0001293_anophthalmia1.84565755
31MP0004133_heterotaxia1.83374565
32MP0005503_abnormal_tendon_morphology1.80917250
33MP0003195_calcinosis1.72783267
34MP0002249_abnormal_larynx_morphology1.71836886
35MP0008058_abnormal_DNA_repair1.71195029
36MP0003045_fibrosis1.70393301
37MP0001545_abnormal_hematopoietic_system1.67420007
38MP0005397_hematopoietic_system_phenotyp1.67420007
39MP0003878_abnormal_ear_physiology1.63792713
40MP0005377_hearing/vestibular/ear_phenot1.63792713
41MP0001984_abnormal_olfaction1.63477754
42MP0000566_synostosis1.59997874
43MP0003283_abnormal_digestive_organ1.59511627
44MP0003119_abnormal_digestive_system1.58894391
45MP0001486_abnormal_startle_reflex1.58217540
46MP0001501_abnormal_sleep_pattern1.53684774
47MP0002928_abnormal_bile_duct1.52912182
48MP0004381_abnormal_hair_follicle1.51038844
49MP0003937_abnormal_limbs/digits/tail_de1.47515907
50MP0003453_abnormal_keratinocyte_physiol1.47337084
51MP0001929_abnormal_gametogenesis1.47328518
52MP0002095_abnormal_skin_pigmentation1.42825361
53MP0002282_abnormal_trachea_morphology1.41745397
54MP0002075_abnormal_coat/hair_pigmentati1.40866904
55MP0002938_white_spotting1.39771570
56MP0005310_abnormal_salivary_gland1.38780950
57MP0000427_abnormal_hair_cycle1.37250629
58MP0002084_abnormal_developmental_patter1.36329683
59MP0003786_premature_aging1.33471425
60MP0005076_abnormal_cell_differentiation1.32298917
61MP0002160_abnormal_reproductive_system1.30967818
62MP0002168_other_aberrant_phenotype1.29617760
63MP0000462_abnormal_digestive_system1.26155937
64MP0000470_abnormal_stomach_morphology1.25776653
65MP0004957_abnormal_blastocyst_morpholog1.24619976
66MP0001529_abnormal_vocalization1.24494234
67MP0001697_abnormal_embryo_size1.24367352
68MP0005389_reproductive_system_phenotype1.23425385
69MP0000579_abnormal_nail_morphology1.23034166
70MP0000631_abnormal_neuroendocrine_gland1.21522070
71MP0008932_abnormal_embryonic_tissue1.21127330
72MP0001340_abnormal_eyelid_morphology1.21046199
73MP0006035_abnormal_mitochondrial_morpho1.20013776
74MP0005360_urolithiasis1.19534148
75MP0002085_abnormal_embryonic_tissue1.18931957
76MP0002086_abnormal_extraembryonic_tissu1.18258369
77MP0002272_abnormal_nervous_system1.17420492
78MP0004197_abnormal_fetal_growth/weight/1.16476697
79MP0005253_abnormal_eye_physiology1.15948704
80MP0000955_abnormal_spinal_cord1.15197257
81MP0001873_stomach_inflammation1.14496570
82MP0000383_abnormal_hair_follicle1.14405203
83MP0000778_abnormal_nervous_system1.13950080
84MP0003656_abnormal_erythrocyte_physiolo1.13518560
85MP0005646_abnormal_pituitary_gland1.13207387
86MP0004142_abnormal_muscle_tone1.13000238
87MP0001963_abnormal_hearing_physiology1.10558053
88MP0002557_abnormal_social/conspecific_i1.10138218
89MP0002822_catalepsy1.10088916
90MP0001186_pigmentation_phenotype1.08388587
91MP0001324_abnormal_eye_pigmentation1.07864430
92MP0002210_abnormal_sex_determination1.07798954
93MP0000569_abnormal_digit_pigmentation1.05782259
94MP0005645_abnormal_hypothalamus_physiol1.04916662
95MP0002837_dystrophic_cardiac_calcinosis1.04834768
96MP0004043_abnormal_pH_regulation1.04540159
97MP0003880_abnormal_central_pattern1.04454370
98MP0001986_abnormal_taste_sensitivity1.04394400
99MP0000639_abnormal_adrenal_gland1.03900363
100MP0000490_abnormal_crypts_of1.03750893
101MP0003111_abnormal_nucleus_morphology1.03225542
102MP0009745_abnormal_behavioral_response1.01296640
103MP0002751_abnormal_autonomic_nervous1.01289476
104MP0000678_abnormal_parathyroid_gland1.00151119
105MP0005410_abnormal_fertilization0.99369461
106MP0004924_abnormal_behavior0.98987561
107MP0005386_behavior/neurological_phenoty0.98987561
108MP0009046_muscle_twitch0.98670963
109MP0000467_abnormal_esophagus_morphology0.94807739
110MP0005058_abnormal_lysosome_morphology0.93962680
111MP0004264_abnormal_extraembryonic_tissu0.93646625
112MP0005391_vision/eye_phenotype0.93634590
113MP0000049_abnormal_middle_ear0.93374985
114MP0002932_abnormal_joint_morphology0.92806638
115MP0000681_abnormal_thyroid_gland0.90280523
116MP0002229_neurodegeneration0.89030133
117MP0010678_abnormal_skin_adnexa0.88812408
118MP0001145_abnormal_male_reproductive0.86499585
119MP0002108_abnormal_muscle_morphology0.86484324
120MP0003137_abnormal_impulse_conducting0.85692900
121MP0009764_decreased_sensitivity_to0.85400628
122MP0002111_abnormal_tail_morphology0.85363995
123MP0003861_abnormal_nervous_system0.84184941
124MP0001919_abnormal_reproductive_system0.84143570
125MP0002114_abnormal_axial_skeleton0.84065113
126MP0002752_abnormal_somatic_nervous0.83842218
127MP0002109_abnormal_limb_morphology0.83371450
128MP0000653_abnormal_sex_gland0.82787003
129MP0001672_abnormal_embryogenesis/_devel0.81844163
130MP0005380_embryogenesis_phenotype0.81844163
131MP0000350_abnormal_cell_proliferation0.81694838
132MP0008961_abnormal_basal_metabolism0.80796559
133MP0005266_abnormal_metabolism0.80701122
134MP0002269_muscular_atrophy0.80006340
135MP0002116_abnormal_craniofacial_bone0.79605805
136MP0003787_abnormal_imprinting0.79329918
137MP0000026_abnormal_inner_ear0.77684955
138MP0003938_abnormal_ear_development0.77596381
139MP0003077_abnormal_cell_cycle0.77200455
140MP0002572_abnormal_emotion/affect_behav0.76176225
141MP0005408_hypopigmentation0.74579392
142MP0008789_abnormal_olfactory_epithelium0.74232532
143MP0008875_abnormal_xenobiotic_pharmacok0.73641598
144MP0004134_abnormal_chest_morphology0.73380558
145MP0000538_abnormal_urinary_bladder0.71475583
146MP0002019_abnormal_tumor_incidence0.71438495
147MP0004811_abnormal_neuron_physiology0.70789655
148MP0001664_abnormal_digestion0.70619499
149MP0002089_abnormal_postnatal_growth/wei0.69078505
150MP0002080_prenatal_lethality0.68875471
151MP0003755_abnormal_palate_morphology0.68018511
152MP0000685_abnormal_immune_system0.68017503
153MP0002697_abnormal_eye_size0.67464860
154MP0010768_mortality/aging0.66794524
155MP0003698_abnormal_male_reproductive0.66650828
156MP0005195_abnormal_posterior_eye0.65837987
157MP0000313_abnormal_cell_death0.64949422
158MP0005499_abnormal_olfactory_system0.64463501
159MP0005394_taste/olfaction_phenotype0.64463501
160MP0003943_abnormal_hepatobiliary_system0.64090860
161MP0002166_altered_tumor_susceptibility0.64085400
162MP0003633_abnormal_nervous_system0.63981124
163MP0002733_abnormal_thermal_nociception0.63776040
164MP0000762_abnormal_tongue_morphology0.63512499
165MP0001730_embryonic_growth_arrest0.63203023
166MP0002796_impaired_skin_barrier0.63110775
167MP0010769_abnormal_survival0.62533015
168MP0001970_abnormal_pain_threshold0.62107391

Predicted human phenotypes

RankGene SetZ-score
1Thyroid-stimulating hormone excess (HP:0002925)6.28520287
2Facial hemangioma (HP:0000329)5.19439267
3Rectal fistula (HP:0100590)4.86133548
4Rectovaginal fistula (HP:0000143)4.86133548
5Rib fusion (HP:0000902)4.83853035
6Concave nail (HP:0001598)4.74003060
7Intestinal fistula (HP:0100819)4.59976889
8Poikiloderma (HP:0001029)4.58160122
9Hypochromic microcytic anemia (HP:0004840)4.28578145
10Vaginal fistula (HP:0004320)4.27059904
11Pancreatic cysts (HP:0001737)4.17681696
12Annular pancreas (HP:0001734)4.15739586
13Anteriorly placed anus (HP:0001545)4.10270899
14Alacrima (HP:0000522)4.09771751
15Pustule (HP:0200039)3.96429325
16Turricephaly (HP:0000262)3.92012835
17Increased IgM level (HP:0003496)3.90675039
18Albinism (HP:0001022)3.88685671
19Pancreatic fibrosis (HP:0100732)3.75640409
20Chronic hepatic failure (HP:0100626)3.72642457
21Coronal craniosynostosis (HP:0004440)3.62603704
22Molar tooth sign on MRI (HP:0002419)3.56414623
23Abnormality of midbrain morphology (HP:0002418)3.56414623
24Abnormality of male internal genitalia (HP:0000022)3.42702046
25Gaze-evoked nystagmus (HP:0000640)3.42369395
26True hermaphroditism (HP:0010459)3.40931704
27Hyperventilation (HP:0002883)3.39496992
28Short chin (HP:0000331)3.38918689
29Orthostatic hypotension (HP:0001278)3.37090044
30Tongue fasciculations (HP:0001308)3.36919359
31Decreased lacrimation (HP:0000633)3.31358151
32Alopecia of scalp (HP:0002293)3.26683296
33Nephronophthisis (HP:0000090)3.22736525
34Ulnar bowing (HP:0003031)3.21081735
35Tubular atrophy (HP:0000092)3.16130472
36Abnormality of the renal medulla (HP:0100957)3.14599719
37Abnormality of the renal cortex (HP:0011035)3.14566016
38Cerebellar dysplasia (HP:0007033)3.09803841
39Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.08948170
40Premature skin wrinkling (HP:0100678)3.07398971
41Growth hormone excess (HP:0000845)3.07031387
42Chromosomal breakage induced by crosslinking agents (HP:0003221)3.02383980
43Squamous cell carcinoma (HP:0002860)3.02105695
44Duplicated collecting system (HP:0000081)2.96905208
45Cystic liver disease (HP:0006706)2.96602929
46Oligodontia (HP:0000677)2.96406445
47Clumsiness (HP:0002312)2.95954003
48Type II lissencephaly (HP:0007260)2.94968750
49Medial flaring of the eyebrow (HP:0010747)2.94355355
50Absent radius (HP:0003974)2.93606211
51Abnormality of the labia minora (HP:0012880)2.92839284
52Absent thumb (HP:0009777)2.91605946
53Abnormality of DNA repair (HP:0003254)2.89462792
54Muscle fibrillation (HP:0010546)2.87364532
55Hypotelorism (HP:0000601)2.86746519
56Attenuation of retinal blood vessels (HP:0007843)2.85928620
57Male infertility (HP:0003251)2.85344838
58Aplasia involving forearm bones (HP:0009822)2.84831572
59Absent forearm bone (HP:0003953)2.84831572
60Increased number of teeth (HP:0011069)2.82540242
61Abnormal hemoglobin (HP:0011902)2.82396119
62Abnormality of the renal collecting system (HP:0004742)2.79121547
63Basal cell carcinoma (HP:0002671)2.77713139
64Congenital hip dislocation (HP:0001374)2.77494417
65Acute lymphatic leukemia (HP:0006721)2.75013838
66Vertebral hypoplasia (HP:0008417)2.70258785
67Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.70258785
68Genetic anticipation (HP:0003743)2.69644524
69Popliteal pterygium (HP:0009756)2.69564865
70Short humerus (HP:0005792)2.66991690
71Astrocytoma (HP:0009592)2.65338094
72Abnormality of the astrocytes (HP:0100707)2.65338094
73Bifid uvula (HP:0000193)2.63749825
74Neoplasm of the oral cavity (HP:0100649)2.58660015
75Poor coordination (HP:0002370)2.58659973
76Muscle fiber atrophy (HP:0100295)2.58511946
77Chromsome breakage (HP:0040012)2.55985396
78Lissencephaly (HP:0001339)2.52970884
79Bile duct proliferation (HP:0001408)2.52760689
80Abnormal biliary tract physiology (HP:0012439)2.52760689
81Abnormal number of incisors (HP:0011064)2.49869150
82Type 2 muscle fiber atrophy (HP:0003554)2.48854631
83Nephrogenic diabetes insipidus (HP:0009806)2.48698689
84Absent speech (HP:0001344)2.48672988
85Urinary glycosaminoglycan excretion (HP:0003541)2.47340264
86Mucopolysacchariduria (HP:0008155)2.47340264
87Truncal obesity (HP:0001956)2.46655244
88Aplasia/hypoplasia of the humerus (HP:0006507)2.46627051
89Occipital encephalocele (HP:0002085)2.43840573
90Split hand (HP:0001171)2.42970345
91Hypotrichosis (HP:0001006)2.42537420
92Premature graying of hair (HP:0002216)2.41812163
93Dysautonomia (HP:0002459)2.37695849
94Narrow nasal bridge (HP:0000446)2.37204902
95Lower limb hyperreflexia (HP:0002395)2.36188540
96Generalized hypopigmentation (HP:0007513)2.34475355
97Hypoplasia of the radius (HP:0002984)2.33962313
98Abnormality of glycosaminoglycan metabolism (HP:0004371)2.33685359
99Abnormality of mucopolysaccharide metabolism (HP:0011020)2.33685359
100Abnormality of polysaccharide metabolism (HP:0011012)2.33685359
101Abnormal drinking behavior (HP:0030082)2.31816494
102Polydipsia (HP:0001959)2.31816494
103Capillary hemangiomas (HP:0005306)2.26522482
104Abnormality of lateral ventricle (HP:0030047)2.24567548
105Congenital hepatic fibrosis (HP:0002612)2.20768808
106Postaxial foot polydactyly (HP:0001830)2.18324266
107Patellar aplasia (HP:0006443)2.18240817
108Genital tract atresia (HP:0001827)2.17345349
109Hypokinesia (HP:0002375)2.17156058
110* Hamartoma (HP:0010566)2.15540536
111Selective tooth agenesis (HP:0001592)2.15300431
112Poor head control (HP:0002421)2.15257843
113Epileptic encephalopathy (HP:0200134)2.14672672
114Vaginal atresia (HP:0000148)2.14662585
115Abnormality of the columella (HP:0009929)2.13463534
116Polyuria (HP:0000103)2.13450763
117Absent/shortened dynein arms (HP:0200106)2.11665722
118Dynein arm defect of respiratory motile cilia (HP:0012255)2.11665722
119Ectopic kidney (HP:0000086)2.10965737
120Choanal stenosis (HP:0000452)2.10442387
121Abnormality of the pons (HP:0007361)2.10225785
122Hypoplastic ischia (HP:0003175)2.07882530
123Gait imbalance (HP:0002141)2.07423455
124Keratoconus (HP:0000563)2.06033906
125Increased corneal curvature (HP:0100692)2.06033906
126Diaphragmatic weakness (HP:0009113)2.05755270
127Diminished movement (HP:0002374)2.05487554
128Optic nerve hypoplasia (HP:0000609)2.05369754
129Broad-based gait (HP:0002136)2.04744486
130Aplasia/Hypoplasia of the uvula (HP:0010293)2.02973009
131Glioma (HP:0009733)2.02355512
132Ependymoma (HP:0002888)2.01873056
133Dysostosis multiplex (HP:0000943)2.01430201
134Abnormal rod and cone electroretinograms (HP:0008323)1.99433190
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.99399666
136Heterotopia (HP:0002282)1.98990403
137Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.98309654
138IgA deficiency (HP:0002720)1.98049252
139Congenital primary aphakia (HP:0007707)1.97202710
140* Tented upper lip vermilion (HP:0010804)1.96941300
141Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.96463436
142Bulbar palsy (HP:0001283)1.94740305
143Aplasia of the musculature (HP:0100854)1.94579974
144Aplasia/Hypoplasia of the spleen (HP:0010451)1.93370431
145Clubbing of toes (HP:0100760)1.93031063
146Abnormality of the ischium (HP:0003174)1.92782589
147Pendular nystagmus (HP:0012043)1.91964403
148Abnormal ciliary motility (HP:0012262)1.91914385
149Ectopic anus (HP:0004397)1.91244121
150Progressive sensorineural hearing impairment (HP:0000408)1.90958338
151Renal cortical cysts (HP:0000803)1.90106070
152Bony spicule pigmentary retinopathy (HP:0007737)1.89462626
153Hypoplasia of the brainstem (HP:0002365)1.89457480
154Aplasia/Hypoplasia of the brainstem (HP:0007362)1.89457480
155Hypoplasia of the pons (HP:0012110)1.88594279
156Colitis (HP:0002583)1.88099195
157Astigmatism (HP:0000483)1.87974200
158Abnormal respiratory motile cilium morphology (HP:0005938)1.87514025
159Abnormal respiratory epithelium morphology (HP:0012253)1.87514025
160Abnormality of the lower motor neuron (HP:0002366)1.87091920
161Bowed forearm bones (HP:0003956)1.86512599
162Bowing of the arm (HP:0006488)1.86512599
163Sloping forehead (HP:0000340)1.86311689
164Ketosis (HP:0001946)1.85205174
165Anencephaly (HP:0002323)1.84921353
166Hyperglycinemia (HP:0002154)1.84735138
167Sclerocornea (HP:0000647)1.83803805
168Aplasia/Hypoplasia of the patella (HP:0006498)1.83685844
169Hypercortisolism (HP:0001578)1.83622307
170Male pseudohermaphroditism (HP:0000037)1.83587830
171Decreased circulating renin level (HP:0003351)1.82993657
172Cheilitis (HP:0100825)1.82214256
173Lip pit (HP:0100267)1.82070976
174Protruding tongue (HP:0010808)1.81948190
175Postaxial hand polydactyly (HP:0001162)1.81325715
176Large eyes (HP:0001090)1.80529900
177Preaxial hand polydactyly (HP:0001177)1.79907043
178Abnormality of placental membranes (HP:0011409)1.79744110
179Amniotic constriction ring (HP:0009775)1.79744110
180* Intestinal atresia (HP:0011100)1.78678162
181Oligodactyly (hands) (HP:0001180)1.76272750
182Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75229334
183Asplenia (HP:0001746)1.73626083
184Chorioretinal atrophy (HP:0000533)1.73180055
185Dandy-Walker malformation (HP:0001305)1.70845311
186Agitation (HP:0000713)1.70817615
187Hypoplastic iliac wings (HP:0002866)1.70242984
188Progressive inability to walk (HP:0002505)1.70188350
189Rhinitis (HP:0012384)1.69909838
190Nonprogressive disorder (HP:0003680)1.67994647
191Abnormal respiratory motile cilium physiology (HP:0012261)1.67652071
192Vitreoretinal degeneration (HP:0000655)1.67176277
193Congenital stationary night blindness (HP:0007642)1.67145275
194Thyroiditis (HP:0100646)1.66943317
195High anterior hairline (HP:0009890)1.66054337

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.55165784
2ICK6.11948773
3MAPK155.75055959
4MAP3K64.71287380
5ADRBK24.66656847
6DDR24.17151632
7UHMK13.18574360
8TLK13.03997387
9MATK2.97485534
10MAP4K22.96887793
11ZAK2.95020612
12PINK12.94866931
13TYRO32.89618484
14FGR2.81562137
15DAPK12.71650232
16MAP3K112.48496589
17YES12.41670632
18BMPR1B2.36330185
19SIK22.22262319
20ACVR1B2.11524455
21EPHA32.04471412
22DYRK1B2.02178530
23PASK1.95893771
24CSK1.81893415
25PIM21.79559521
26BMX1.74103864
27PRKD21.72756609
28AKT31.64475174
29NEK21.63430135
30WNK31.61622914
31TRIM281.53520035
32CDK71.48090112
33CASK1.42208325
34STK381.42020748
35STK38L1.40772937
36PDGFRA1.39721777
37CAMK1G1.36983586
38RPS6KL11.34509657
39RPS6KC11.34509657
40MAP3K41.33930051
41WNK41.33110983
42NTRK21.31842507
43PRPF4B1.31467798
44NUAK11.28269904
45MAP3K71.26875160
46IRAK11.26587507
47INSRR1.26501760
48FGFR21.26014954
49SIK31.25279644
50RPS6KA51.25136507
51PIM11.22425617
52NLK1.20858965
53MAP3K101.20346199
54LATS11.18813797
55MAPK111.18569042
56RPS6KA61.17862143
57ADRBK11.15748508
58PHKG21.14816142
59PHKG11.14816142
60HIPK21.14671673
61MARK31.14147203
62CDC42BPA1.09958573
63TGFBR11.09203434
64GRK11.07428981
65STK391.01801901
66CSNK1A1L1.00427411
67PKN21.00180001
68GSK3A0.99027888
69CAMK1D0.98728088
70TRPM70.96772559
71CDK120.96203208
72NME10.95423472
73DYRK30.94088431
74MAPK130.93727608
75SGK20.93687464
76CDK60.92799084
77CHEK20.88990249
78CAMK40.88729963
79DYRK20.87218988
80ATR0.83445197
81TAOK20.82645631
82MAP2K70.78376657
83TXK0.77302959
84TIE10.77050429
85RAF10.76735419
86PRKCG0.74117980
87PRKD30.73397714
88SGK4940.71505832
89SGK2230.71505832
90ERBB30.70816448
91MELK0.70792456
92FGFR30.70459267
93MKNK20.70226573
94RPS6KA10.66414030
95MTOR0.63166134
96CLK10.62259813
97PRKAA10.61931476
98PRKCE0.61220833
99CSNK1G30.61217915
100LATS20.61015964
101TEC0.59735433
102MARK10.59295005
103STK30.59257395
104PLK10.58212303
105GRK60.57105301
106MAP2K60.56675333
107BCR0.56649954
108CAMK10.56052576
109KSR10.55849174
110OXSR10.55240679
111ITK0.53150857
112PRKCZ0.51422734
113CAMK2B0.50881863
114MAP4K10.50159377
115LYN0.50072277
116BRD40.48056097
117CDK20.47664428
118WNK10.47633322
119OBSCN0.47313461
120MAPK40.46603336
121PTK2B0.46257665
122RPS6KB10.46111708
123CSNK1G20.45050079
124CSNK1D0.44215466
125PAK30.43351075
126BTK0.42322682
127SGK30.41963245
128SGK10.41101967
129PRKCI0.40829674
130PRKCQ0.40653091
131MAPK30.39110924
132NEK60.38863496
133MAPK140.38799968
134CDK40.38650317
135MAPK100.38172400
136MAP2K20.37023519
137CDK180.36843267
138CDC70.36699290
139BCKDK0.36548243
140PKN10.36539093
141MAPK10.36286818
142FGFR10.36121979
143PLK40.35420469
144ERBB20.35315004
145MARK20.34761663
146CHEK10.34731505
147CHUK0.34015897
148VRK10.33655482
149EGFR0.33445915
150CDK190.33385745
151CSNK2A10.32220967
152CDK150.32158718
153CDK10.31974740
154CSNK1G10.31123214
155CDK11A0.30100443
156CDK80.29311541
157PDGFRB0.28328882
158CAMK2G0.28176138
159RPS6KB20.27964033
160ATM0.25879575
161MAPK90.25809095
162SIK10.25719243
163GSK3B0.24683103
164CDK140.23312750
165RPS6KA30.21967630
166CAMK2D0.21582160
167CSNK2A20.20894430
168CAMK2A0.20752192
169AURKA0.19483417
170LCK0.18704563
171INSR0.18378314
172BRSK10.17120306
173PRKCD0.17041912
174MAP3K90.16375691
175MAPKAPK20.16231855
176AKT10.15291060
177CDK50.14364230
178JAK20.11962996
179TNK20.11700157

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.96959978
2Base excision repair_Homo sapiens_hsa034104.92423019
3Mismatch repair_Homo sapiens_hsa034304.71844016
4DNA replication_Homo sapiens_hsa030303.82125674
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.26573104
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.97966850
7Systemic lupus erythematosus_Homo sapiens_hsa053222.69708489
8Notch signaling pathway_Homo sapiens_hsa043302.67889951
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.56513281
10ABC transporters_Homo sapiens_hsa020102.43582289
11Butanoate metabolism_Homo sapiens_hsa006502.32047829
12Hedgehog signaling pathway_Homo sapiens_hsa043402.27698303
13Olfactory transduction_Homo sapiens_hsa047402.24098523
14Phototransduction_Homo sapiens_hsa047442.19174845
15Spliceosome_Homo sapiens_hsa030402.08941762
16Circadian rhythm_Homo sapiens_hsa047102.08790752
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.08735239
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.00159640
19mRNA surveillance pathway_Homo sapiens_hsa030151.99178915
20mTOR signaling pathway_Homo sapiens_hsa041501.98654858
21Fanconi anemia pathway_Homo sapiens_hsa034601.94085313
22Nucleotide excision repair_Homo sapiens_hsa034201.93266889
23Taste transduction_Homo sapiens_hsa047421.74493958
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.74249714
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.70705709
26Glycerolipid metabolism_Homo sapiens_hsa005611.65235858
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.64246552
28Arginine and proline metabolism_Homo sapiens_hsa003301.63723019
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63099600
30RNA transport_Homo sapiens_hsa030131.61858152
31Basal cell carcinoma_Homo sapiens_hsa052171.56465123
32Hippo signaling pathway_Homo sapiens_hsa043901.55021422
33Homologous recombination_Homo sapiens_hsa034401.54860831
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51816394
35Lysine degradation_Homo sapiens_hsa003101.51145399
36Nitrogen metabolism_Homo sapiens_hsa009101.46495888
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45951395
38Biosynthesis of amino acids_Homo sapiens_hsa012301.42434136
39Wnt signaling pathway_Homo sapiens_hsa043101.41802656
40Linoleic acid metabolism_Homo sapiens_hsa005911.37333714
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35283917
42Colorectal cancer_Homo sapiens_hsa052101.35099353
43Fatty acid metabolism_Homo sapiens_hsa012121.27888319
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.26682224
45Longevity regulating pathway - mammal_Homo sapiens_hsa042111.24421423
46Regulation of autophagy_Homo sapiens_hsa041401.23836603
47Primary immunodeficiency_Homo sapiens_hsa053401.23475312
48Folate biosynthesis_Homo sapiens_hsa007901.22474792
49Sulfur relay system_Homo sapiens_hsa041221.20332223
50Bladder cancer_Homo sapiens_hsa052191.17775741
51Cell cycle_Homo sapiens_hsa041101.16285226
52Ovarian steroidogenesis_Homo sapiens_hsa049131.13670019
53VEGF signaling pathway_Homo sapiens_hsa043701.13621193
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12889354
55Adherens junction_Homo sapiens_hsa045201.12814570
56p53 signaling pathway_Homo sapiens_hsa041151.12776377
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10737937
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07341944
59Dorso-ventral axis formation_Homo sapiens_hsa043201.04656618
60Maturity onset diabetes of the young_Homo sapiens_hsa049501.03365177
61Nicotine addiction_Homo sapiens_hsa050330.99877842
62Non-homologous end-joining_Homo sapiens_hsa034500.97262111
63Shigellosis_Homo sapiens_hsa051310.96144601
64T cell receptor signaling pathway_Homo sapiens_hsa046600.95380281
65RNA polymerase_Homo sapiens_hsa030200.94325917
66Steroid biosynthesis_Homo sapiens_hsa001000.91770581
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87396746
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.86756350
69Fructose and mannose metabolism_Homo sapiens_hsa000510.84443863
70Salivary secretion_Homo sapiens_hsa049700.84004696
71Gap junction_Homo sapiens_hsa045400.82197389
72Sphingolipid metabolism_Homo sapiens_hsa006000.82149688
73Circadian entrainment_Homo sapiens_hsa047130.81600915
74Fatty acid elongation_Homo sapiens_hsa000620.81401706
75ErbB signaling pathway_Homo sapiens_hsa040120.81193098
76Oocyte meiosis_Homo sapiens_hsa041140.78957981
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78182592
78Ether lipid metabolism_Homo sapiens_hsa005650.77545950
79Choline metabolism in cancer_Homo sapiens_hsa052310.76800118
80Tryptophan metabolism_Homo sapiens_hsa003800.75583607
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74757917
82Calcium signaling pathway_Homo sapiens_hsa040200.74486124
83Histidine metabolism_Homo sapiens_hsa003400.74052886
84MicroRNAs in cancer_Homo sapiens_hsa052060.74014227
85Inositol phosphate metabolism_Homo sapiens_hsa005620.73993355
86Peroxisome_Homo sapiens_hsa041460.73605828
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73534979
88Propanoate metabolism_Homo sapiens_hsa006400.71704321
89Acute myeloid leukemia_Homo sapiens_hsa052210.70369383
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68867210
91Viral carcinogenesis_Homo sapiens_hsa052030.64124000
92B cell receptor signaling pathway_Homo sapiens_hsa046620.63475858
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.62467939
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62398862
95Chronic myeloid leukemia_Homo sapiens_hsa052200.62351428
96Endometrial cancer_Homo sapiens_hsa052130.61667369
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.60662409
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.60352792
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59218108
100TGF-beta signaling pathway_Homo sapiens_hsa043500.59111306
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58322905
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56680769
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.56524955
104Purine metabolism_Homo sapiens_hsa002300.54830617
105N-Glycan biosynthesis_Homo sapiens_hsa005100.54786676
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.54428670
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53459306
108Chemical carcinogenesis_Homo sapiens_hsa052040.53319859
109Long-term depression_Homo sapiens_hsa047300.52667159
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.51469263
111GABAergic synapse_Homo sapiens_hsa047270.50910733
112Oxytocin signaling pathway_Homo sapiens_hsa049210.50701069
113Legionellosis_Homo sapiens_hsa051340.48677446
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48047663
115Insulin signaling pathway_Homo sapiens_hsa049100.47790394
116FoxO signaling pathway_Homo sapiens_hsa040680.47719120
117AMPK signaling pathway_Homo sapiens_hsa041520.47497305
118One carbon pool by folate_Homo sapiens_hsa006700.47351444
119Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46796704
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45887164
121MAPK signaling pathway_Homo sapiens_hsa040100.43453799
122Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42602818
123Arachidonic acid metabolism_Homo sapiens_hsa005900.41796914
124Thyroid cancer_Homo sapiens_hsa052160.39966000
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39691715
126Cholinergic synapse_Homo sapiens_hsa047250.38857133
127Viral myocarditis_Homo sapiens_hsa054160.37264852
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36821661
129Retinol metabolism_Homo sapiens_hsa008300.35798625
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33397094
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32806740
132Insulin secretion_Homo sapiens_hsa049110.31570894
133Estrogen signaling pathway_Homo sapiens_hsa049150.31266368
134Alcoholism_Homo sapiens_hsa050340.30978620
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30047218
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.29742448
137Renin secretion_Homo sapiens_hsa049240.29666851
138Pancreatic cancer_Homo sapiens_hsa052120.29239205
139cAMP signaling pathway_Homo sapiens_hsa040240.29148212
140Non-small cell lung cancer_Homo sapiens_hsa052230.29099486
141RNA degradation_Homo sapiens_hsa030180.29021533
142Epstein-Barr virus infection_Homo sapiens_hsa051690.29020231
143Small cell lung cancer_Homo sapiens_hsa052220.28479362
144Hepatitis B_Homo sapiens_hsa051610.26644961
145Morphine addiction_Homo sapiens_hsa050320.24560880
146Pathways in cancer_Homo sapiens_hsa052000.21820947
147Endocytosis_Homo sapiens_hsa041440.21059780
148Melanogenesis_Homo sapiens_hsa049160.20677127
149Synaptic vesicle cycle_Homo sapiens_hsa047210.20418549
150Ribosome_Homo sapiens_hsa030100.20332711
151Axon guidance_Homo sapiens_hsa043600.19499427
152HTLV-I infection_Homo sapiens_hsa051660.19269109
153PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18378319
154Basal transcription factors_Homo sapiens_hsa030220.17281455
155Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17045494
156Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.16470210
157Selenocompound metabolism_Homo sapiens_hsa004500.15962196

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