DISC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation via MHC class Ib (GO:0002475)4.82179953
2regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.62029670
3superoxide anion generation (GO:0042554)4.46188450
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.36643377
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.30986290
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.24065815
7negative regulation of cell killing (GO:0031342)4.24065815
8positive regulation of B cell differentiation (GO:0045579)4.22675081
9antigen processing and presentation of endogenous antigen (GO:0019883)4.20678071
10mature B cell differentiation involved in immune response (GO:0002313)4.18166226
11response to peptidoglycan (GO:0032494)4.06147875
12mesenchymal cell differentiation involved in kidney development (GO:0072161)3.98638831
13mesenchymal cell differentiation involved in renal system development (GO:2001012)3.98638831
14polyketide metabolic process (GO:0030638)3.96566581
15doxorubicin metabolic process (GO:0044598)3.96566581
16daunorubicin metabolic process (GO:0044597)3.96566581
17germinal center formation (GO:0002467)3.95126542
18cellular extravasation (GO:0045123)3.93906825
19regulation of interferon-beta biosynthetic process (GO:0045357)3.92265522
20positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.86063546
21mature B cell differentiation (GO:0002335)3.82059400
22macrophage activation (GO:0042116)3.80893771
23positive regulation by symbiont of host defense response (GO:0052509)3.76459566
24modulation by symbiont of host defense response (GO:0052031)3.76459566
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.76459566
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.76459566
27positive regulation by organism of defense response of other organism involved in symbiotic interact3.76459566
28modulation by symbiont of host immune response (GO:0052553)3.76459566
29regulation of gamma-delta T cell activation (GO:0046643)3.76380568
30immunoglobulin mediated immune response (GO:0016064)3.67620375
31positive regulation of cellular amide metabolic process (GO:0034250)3.66802272
32regulation of hypersensitivity (GO:0002883)3.58244938
33regulation of B cell differentiation (GO:0045577)3.55169169
34negative regulation of mast cell activation (GO:0033004)3.54339001
35regulation of gamma-delta T cell differentiation (GO:0045586)3.53954648
36negative regulation of interleukin-12 production (GO:0032695)3.51017410
37positive regulation of mast cell activation (GO:0033005)3.50094520
38myeloid cell activation involved in immune response (GO:0002275)3.47564868
39positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.44744664
40regulation of interleukin-6 biosynthetic process (GO:0045408)3.36291135
41positive regulation of interferon-alpha production (GO:0032727)3.31819770
42negative regulation of T cell mediated immunity (GO:0002710)3.30438056
43regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.30182975
44response to host immune response (GO:0052572)3.29753895
45response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.29753895
46response to interleukin-15 (GO:0070672)3.28120211
47T-helper 1 type immune response (GO:0042088)3.26888998
48cellular response to interleukin-15 (GO:0071350)3.25864929
49energy homeostasis (GO:0097009)3.25065487
50activated T cell proliferation (GO:0050798)3.23301350
51positive regulation of gamma-delta T cell activation (GO:0046645)3.21935797
52defense response to protozoan (GO:0042832)3.20539881
53positive regulation of mast cell activation involved in immune response (GO:0033008)3.19226243
54positive regulation of mast cell degranulation (GO:0043306)3.19226243
55regulation of myeloid leukocyte mediated immunity (GO:0002886)3.15777426
56regulation of activation of Janus kinase activity (GO:0010533)3.14408042
57DNA double-strand break processing (GO:0000729)3.12845463
58B cell mediated immunity (GO:0019724)3.10782860
59regulation of interferon-alpha production (GO:0032647)3.10275266
60adaptation of signaling pathway (GO:0023058)3.05709695
61positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.05667374
62positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.03784015
63regulation of granulocyte differentiation (GO:0030852)3.02788850
64interferon-gamma production (GO:0032609)3.01641714
65T cell migration (GO:0072678)3.00886766
66detection of external biotic stimulus (GO:0098581)3.00033372
67cellular response to ethanol (GO:0071361)2.98842988
68microglial cell activation (GO:0001774)2.98830340
69replicative senescence (GO:0090399)2.97086562
70detection of other organism (GO:0098543)2.96643987
71negative regulation of lymphocyte mediated immunity (GO:0002707)2.96152306
72neutrophil mediated immunity (GO:0002446)2.95503641
73negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.93575995
74regulation of B cell receptor signaling pathway (GO:0050855)2.93047342
75response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.92942415
76response to host (GO:0075136)2.92942415
77response to host defenses (GO:0052200)2.92942415
78B cell receptor signaling pathway (GO:0050853)2.88758943
79dendritic cell migration (GO:0036336)2.87981758
80centriole assembly (GO:0098534)2.87964090
81phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.87386149
82dendritic cell chemotaxis (GO:0002407)2.86875102
83negative regulation of B cell proliferation (GO:0030889)2.86369868
84regulation of RIG-I signaling pathway (GO:0039535)2.85980336
85regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.85889535
86regulation of interleukin-8 biosynthetic process (GO:0045414)2.85686643
87I-kappaB phosphorylation (GO:0007252)2.84664795
88negative regulation of DNA-dependent DNA replication (GO:2000104)2.84477875
89mast cell activation (GO:0045576)2.83914437
90positive regulation of granulocyte differentiation (GO:0030854)2.83516566
91negative regulation of myeloid cell apoptotic process (GO:0033033)2.83188881
92positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.82463454
93positive regulation of antigen processing and presentation (GO:0002579)2.81459084
94neutrophil activation (GO:0042119)2.80509064
95meiotic chromosome segregation (GO:0045132)2.79111445
96positive regulation of interleukin-1 beta secretion (GO:0050718)2.77833578
97negative regulation of interleukin-6 production (GO:0032715)2.76990635
98negative regulation of viral genome replication (GO:0045071)2.75602562
99positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.75174156
100positive regulation of toll-like receptor signaling pathway (GO:0034123)2.74957443
101regulation of interleukin-12 biosynthetic process (GO:0045075)2.74078235
102response to protozoan (GO:0001562)2.73734255
103antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.73361274
104negative regulation of bone resorption (GO:0045779)2.71843991
105detection of biotic stimulus (GO:0009595)2.71771113
106positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.71707645
107response to muramyl dipeptide (GO:0032495)2.71649151
108G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.71461436
109detection of molecule of bacterial origin (GO:0032490)2.69559642
110regulation of heat generation (GO:0031650)2.69341199
111negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.68715383
112cell wall macromolecule catabolic process (GO:0016998)2.67952485
113regulation of mast cell activation (GO:0033003)2.66682928
114neutrophil activation involved in immune response (GO:0002283)2.66193062
115negative regulation of T-helper cell differentiation (GO:0045623)2.65667329
116negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.65667329
117regulation of dendritic cell antigen processing and presentation (GO:0002604)2.63970595
118regulation of germinal center formation (GO:0002634)2.61110167
119myeloid leukocyte mediated immunity (GO:0002444)2.60350841
120negative regulation of granulocyte differentiation (GO:0030853)2.59589488
121interleukin-6-mediated signaling pathway (GO:0070102)2.58478018
122DNA synthesis involved in DNA repair (GO:0000731)2.55227321
123negative regulation of adaptive immune response (GO:0002820)2.54620185
124regulation of T cell mediated cytotoxicity (GO:0001914)2.54614025
125kinetochore assembly (GO:0051382)2.53809729
126positive T cell selection (GO:0043368)2.53509994
127leukocyte degranulation (GO:0043299)2.53401969
128negative regulation of leukocyte mediated immunity (GO:0002704)2.53256315
129positive thymic T cell selection (GO:0045059)2.52885936
130myeloid dendritic cell activation (GO:0001773)2.51846126
131regulation of mast cell degranulation (GO:0043304)2.51409892
132positive regulation of heat generation (GO:0031652)2.50601103
133positive regulation of interleukin-10 production (GO:0032733)2.50384967
134positive regulation of interleukin-1 secretion (GO:0050716)2.50161055
135granulocyte activation (GO:0036230)2.49947089
136T-helper cell differentiation (GO:0042093)2.49043522
137CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.49043522
138positive regulation of DNA-dependent DNA replication (GO:2000105)2.48887710
139myeloid leukocyte activation (GO:0002274)2.48498073
140regulation of mast cell activation involved in immune response (GO:0033006)2.48231615
141negative thymic T cell selection (GO:0045060)2.48221487
142I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.48053919
143regulation of nuclear cell cycle DNA replication (GO:0033262)2.47020691
144cellular response to exogenous dsRNA (GO:0071360)2.44704669
145detection of bacterium (GO:0016045)2.44623045
146B cell homeostasis (GO:0001782)2.43871761
147T cell lineage commitment (GO:0002360)2.42849869
148macrophage activation involved in immune response (GO:0002281)2.42279989
149cellular response to zinc ion (GO:0071294)2.41475337
150superoxide metabolic process (GO:0006801)2.40941641
151glycosphingolipid catabolic process (GO:0046479)2.39360878
152regulation of interleukin-1 beta secretion (GO:0050706)2.39207494
153histamine secretion (GO:0001821)2.38968115
154microtubule depolymerization (GO:0007019)2.38852238
155production of molecular mediator involved in inflammatory response (GO:0002532)2.37734982
156positive regulation of interferon-beta production (GO:0032728)2.36939727
157B cell proliferation (GO:0042100)2.36214673
158negative regulation of homotypic cell-cell adhesion (GO:0034111)2.35739483
159positive regulation of interferon-gamma production (GO:0032729)2.34521950
160positive regulation of T cell mediated cytotoxicity (GO:0001916)2.33913341
161leukocyte aggregation (GO:0070486)2.33545273
162positive regulation of response to biotic stimulus (GO:0002833)2.31362696
163CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.31249722
164regulation of antigen processing and presentation (GO:0002577)2.30199330

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.98370238
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.12450918
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.67768633
4E2F7_22180533_ChIP-Seq_HELA_Human3.57132096
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.13992961
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.77838165
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.76347583
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.71963198
9GBX2_23144817_ChIP-Seq_PC3_Human2.69394698
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.61859461
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.59630886
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.56434903
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.38359265
14SCL_19346495_ChIP-Seq_HPC-7_Human2.26312907
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.25979887
16* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19441721
17* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17955763
18SUZ12_27294783_Chip-Seq_NPCs_Mouse2.12509565
19NFE2_27457419_Chip-Seq_LIVER_Mouse2.11657444
20PCGF2_27294783_Chip-Seq_NPCs_Mouse2.05874384
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.98579818
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97011165
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.96371455
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94672409
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93399505
26STAT3_18555785_Chip-Seq_ESCs_Mouse1.85250144
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.84728086
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.82250090
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80791220
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78538514
31IGF1R_20145208_ChIP-Seq_DFB_Human1.73756310
32SUZ12_18555785_Chip-Seq_ESCs_Mouse1.73520903
33NMYC_18555785_Chip-Seq_ESCs_Mouse1.71823907
34E2F1_18555785_Chip-Seq_ESCs_Mouse1.70648607
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68469673
36P53_22387025_ChIP-Seq_ESCs_Mouse1.65755532
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65504592
38EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.65477669
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.62200467
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60146913
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.59287150
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.57863134
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56613511
44TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.55986401
45EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.55691779
46PU1_27457419_Chip-Seq_LIVER_Mouse1.55467399
47RUNX1_27457419_Chip-Seq_LIVER_Mouse1.54070259
48PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52890053
49RUNX_20019798_ChIP-Seq_JUKART_Human1.51120361
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50013948
51EWS_26573619_Chip-Seq_HEK293_Human1.49225987
52VDR_24787735_ChIP-Seq_THP-1_Human1.48644055
53VDR_22108803_ChIP-Seq_LS180_Human1.47176056
54MYB_26560356_Chip-Seq_TH2_Human1.45342085
55SOX2_18555785_Chip-Seq_ESCs_Mouse1.44841696
56P300_18555785_Chip-Seq_ESCs_Mouse1.44055438
57CMYC_18555785_Chip-Seq_ESCs_Mouse1.43978690
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43415346
59GATA3_26560356_Chip-Seq_TH2_Human1.42753797
60ZFX_18555785_Chip-Seq_ESCs_Mouse1.42426576
61ZNF274_21170338_ChIP-Seq_K562_Hela1.40663629
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40154049
63* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38707884
64OCT4_18555785_Chip-Seq_ESCs_Mouse1.38359142
65* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37357651
66* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37357651
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34925089
68* SPI1_23547873_ChIP-Seq_NB4_Human1.33080338
69CTCF_18555785_Chip-Seq_ESCs_Mouse1.32923761
70ESRRB_18555785_Chip-Seq_ESCs_Mouse1.30711189
71EZH2_22144423_ChIP-Seq_EOC_Human1.29971863
72NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29896241
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29867521
74KLF4_18555785_Chip-Seq_ESCs_Mouse1.28752775
75GATA3_27048872_Chip-Seq_THYMUS_Human1.28585302
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28024992
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.26782789
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26040147
79* DROSHA_22980978_ChIP-Seq_HELA_Human1.25984984
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.24082117
81SMAD1_18555785_Chip-Seq_ESCs_Mouse1.22438768
82TP53_16413492_ChIP-PET_HCT116_Human1.21855198
83* STAT3_23295773_ChIP-Seq_U87_Human1.21408454
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20710719
85* P300_19829295_ChIP-Seq_ESCs_Human1.19251742
86LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19243498
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18765908
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18624487
89GATA1_22025678_ChIP-Seq_K562_Human1.18281646
90FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18028171
91TAF15_26573619_Chip-Seq_HEK293_Human1.17270896
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16612674
93OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16262874
94* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16228380
95MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15989615
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15641418
97* SMAD4_21799915_ChIP-Seq_A2780_Human1.14654439
98* TCF4_23295773_ChIP-Seq_U87_Human1.14354626
99BCAT_22108803_ChIP-Seq_LS180_Human1.13943228
100FLI1_21867929_ChIP-Seq_TH2_Mouse1.11360032
101FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11174663
102SMRT_27268052_Chip-Seq_Bcells_Human1.10425879
103CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09376589
104CRX_20693478_ChIP-Seq_RETINA_Mouse1.07634728
105GATA2_21666600_ChIP-Seq_HMVEC_Human1.07477767
106HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05948804
107PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05781132
108* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05591480
109CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05356792
110SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04087368
111BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03940879
112LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02935226
113RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02439102
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02380513
115CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01667978
116E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01364322
117* TAL1_26923725_Chip-Seq_HPCs_Mouse1.00951229
118ER_23166858_ChIP-Seq_MCF-7_Human1.00773333
119PU_27001747_Chip-Seq_BMDM_Mouse1.00487991
120RXR_22108803_ChIP-Seq_LS180_Human1.00196689
121* AHR_22903824_ChIP-Seq_MCF-7_Human1.00009699
122VDR_24763502_ChIP-Seq_THP-1_Human0.99212026
123STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98833994
124TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98582028
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98230396
126RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98079193
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98065566
128RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97294515
129KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96242531
130MYB_26560356_Chip-Seq_TH1_Human0.96152430
131* ARNT_22903824_ChIP-Seq_MCF-7_Human0.95167417
132SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94747208
133AR_21572438_ChIP-Seq_LNCaP_Human0.94418322
134TCF4_22108803_ChIP-Seq_LS180_Human0.94294667
135AR_25329375_ChIP-Seq_VCAP_Human0.93645032
136SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92275826
137SPI1_23127762_ChIP-Seq_K562_Human0.92010163
138CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91762097
139* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90641216
140SRF_21415370_ChIP-Seq_HL-1_Mouse0.90571353
141ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90401640
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90274353
143PIAS1_25552417_ChIP-Seq_VCAP_Human0.90195082
144CBP_20019798_ChIP-Seq_JUKART_Human0.89680000
145IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89680000
146RNF2_27304074_Chip-Seq_NSC_Mouse0.88626978
147SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88179173
148RUNX2_22187159_ChIP-Seq_PCA_Human0.87507337
149NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86998466

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.60297413
2MP0000569_abnormal_digit_pigmentation3.10627908
3MP0000015_abnormal_ear_pigmentation2.93714481
4MP0002396_abnormal_hematopoietic_system2.79680405
5MP0003303_peritoneal_inflammation2.76131314
6MP0001188_hyperpigmentation2.63721800
7MP0005174_abnormal_tail_pigmentation2.60143116
8MP0005671_abnormal_response_to2.55560553
9MP0009785_altered_susceptibility_to2.46914391
10MP0003787_abnormal_imprinting2.43719429
11MP0000566_synostosis2.42206991
12MP0002419_abnormal_innate_immunity2.33881258
13MP0009697_abnormal_copulation2.21526397
14MP0002148_abnormal_hypersensitivity_rea2.18497773
15MP0005075_abnormal_melanosome_morpholog2.12125938
16MP0003183_abnormal_peptide_metabolism2.09543959
17MP0006292_abnormal_olfactory_placode2.09454452
18MP0001790_abnormal_immune_system2.07471712
19MP0005387_immune_system_phenotype2.07471712
20MP0008058_abnormal_DNA_repair1.96942477
21MP0002452_abnormal_antigen_presenting1.95296031
22MP0004381_abnormal_hair_follicle1.89086049
23MP0001986_abnormal_taste_sensitivity1.86464175
24MP0008057_abnormal_DNA_replication1.85538095
25MP0005025_abnormal_response_to1.84678357
26MP0006082_CNS_inflammation1.83749089
27MP0005000_abnormal_immune_tolerance1.79559752
28MP0001800_abnormal_humoral_immune1.78427027
29MP0002095_abnormal_skin_pigmentation1.77279730
30MP0003724_increased_susceptibility_to1.75622741
31MP0001819_abnormal_immune_cell1.74885508
32MP0002277_abnormal_respiratory_mucosa1.74718057
33MP0002723_abnormal_immune_serum1.73252393
34MP0003763_abnormal_thymus_physiology1.72307825
35MP0002420_abnormal_adaptive_immunity1.71300339
36MP0008260_abnormal_autophagy1.70695441
37MP0002132_abnormal_respiratory_system1.68897971
38MP0000685_abnormal_immune_system1.67752219
39MP0005171_absent_coat_pigmentation1.63321657
40MP0005646_abnormal_pituitary_gland1.57645213
41MP0000372_irregular_coat_pigmentation1.57450431
42MP0001853_heart_inflammation1.57068355
43MP0004742_abnormal_vestibular_system1.56333589
44MP0004484_altered_response_of1.51932938
45MP0005167_abnormal_blood-brain_barrier1.49363494
46MP0003195_calcinosis1.48605971
47MP0005464_abnormal_platelet_physiology1.47493070
48MP0001533_abnormal_skeleton_physiology1.46509957
49MP0003111_abnormal_nucleus_morphology1.45071486
50MP0004883_abnormal_blood_vessel1.44443646
51MP0003693_abnormal_embryo_hatching1.43079616
52MP0005377_hearing/vestibular/ear_phenot1.42533809
53MP0003878_abnormal_ear_physiology1.42533809
54MP0010094_abnormal_chromosome_stability1.41395570
55MP0009764_decreased_sensitivity_to1.37765824
56MP0008004_abnormal_stomach_pH1.36365485
57MP0004782_abnormal_surfactant_physiolog1.35527430
58MP0002398_abnormal_bone_marrow1.34954042
59MP0003136_yellow_coat_color1.33723470
60MP0002876_abnormal_thyroid_physiology1.33209944
61MP0003436_decreased_susceptibility_to1.32437137
62MP0008007_abnormal_cellular_replicative1.32211364
63MP0005310_abnormal_salivary_gland1.27164710
64MP0000490_abnormal_crypts_of1.26626003
65MP0001545_abnormal_hematopoietic_system1.26022213
66MP0005397_hematopoietic_system_phenotyp1.26022213
67MP0009278_abnormal_bone_marrow1.25642734
68MP0009333_abnormal_splenocyte_physiolog1.25106264
69MP0004808_abnormal_hematopoietic_stem1.24591146
70MP0000371_diluted_coat_color1.23543362
71MP0002405_respiratory_system_inflammati1.23017272
72MP0000716_abnormal_immune_system1.22559327
73MP0003866_abnormal_defecation1.21481585
74MP0001485_abnormal_pinna_reflex1.21411985
75MP0002102_abnormal_ear_morphology1.20615163
76MP0001186_pigmentation_phenotype1.18142662
77MP0005164_abnormal_response_to1.17302917
78MP0002638_abnormal_pupillary_reflex1.13156312
79MP0005451_abnormal_body_composition1.12429062
80MP0005551_abnormal_eye_electrophysiolog1.12237668
81MP0004084_abnormal_cardiac_muscle1.11624759
82MP0005409_darkened_coat_color1.11074812
83MP0002006_tumorigenesis1.11035664
84MP0005645_abnormal_hypothalamus_physiol1.10199393
85MP0003300_gastrointestinal_ulcer1.09928768
86MP0000689_abnormal_spleen_morphology1.08394364
87MP0002075_abnormal_coat/hair_pigmentati1.08241634
88MP0003828_pulmonary_edema1.06745519
89MP0008877_abnormal_DNA_methylation1.06167169
90MP0002933_joint_inflammation1.06111796
91MP0005670_abnormal_white_adipose1.03573120
92MP0003690_abnormal_glial_cell1.03098722
93MP0002998_abnormal_bone_remodeling1.02768392
94MP0004130_abnormal_muscle_cell1.01479876
95MP0003646_muscle_fatigue1.00592311
96MP0008469_abnormal_protein_level0.99275110
97MP0001119_abnormal_female_reproductive0.97733288
98MP0005257_abnormal_intraocular_pressure0.97535216
99MP0002429_abnormal_blood_cell0.94764353
100MP0002332_abnormal_exercise_endurance0.93196240
101MP0002166_altered_tumor_susceptibility0.93102744
102MP0002163_abnormal_gland_morphology0.93049687
103MP0008961_abnormal_basal_metabolism0.92769455
104MP0002722_abnormal_immune_system0.92313564
105MP0010368_abnormal_lymphatic_system0.92249316
106MP0000681_abnormal_thyroid_gland0.92226049
107MP0001501_abnormal_sleep_pattern0.92069046
108MP0001845_abnormal_inflammatory_respons0.90440575
109MP0000249_abnormal_blood_vessel0.89185832
110MP0004510_myositis0.87944219
111MP0003172_abnormal_lysosome_physiology0.86510182
112MP0001851_eye_inflammation0.85840430
113MP0010155_abnormal_intestine_physiology0.85582199
114MP0003191_abnormal_cellular_cholesterol0.83169563
115MP0003718_maternal_effect0.82515018
116MP0004885_abnormal_endolymph0.82475858
117MP0000465_gastrointestinal_hemorrhage0.81647005
118MP0003941_abnormal_skin_development0.79911210
119MP0003077_abnormal_cell_cycle0.79577315
120MP0003890_abnormal_embryonic-extraembry0.79362514
121MP0001873_stomach_inflammation0.77961317
122MP0005379_endocrine/exocrine_gland_phen0.76412904
123MP0003448_altered_tumor_morphology0.76246327
124MP0000703_abnormal_thymus_morphology0.74942880
125MP0000427_abnormal_hair_cycle0.74554959
126MP0002009_preneoplasia0.73269800
127MP0010386_abnormal_urinary_bladder0.73045902
128MP0000858_altered_metastatic_potential0.72549514
129MP0001663_abnormal_digestive_system0.71942566
130MP0004142_abnormal_muscle_tone0.71385530
131* MP0001486_abnormal_startle_reflex0.70227472
132MP0003045_fibrosis0.68503721
133MP0003879_abnormal_hair_cell0.66087140
134MP0000920_abnormal_myelination0.65947675
135MP0005647_abnormal_sex_gland0.65512325
136MP0003632_abnormal_nervous_system0.65162589
137MP0009763_increased_sensitivity_to0.65082669
138MP0000343_altered_response_to0.64634224
139MP0000678_abnormal_parathyroid_gland0.64469922
140MP0008775_abnormal_heart_ventricle0.64451862
141MP0001879_abnormal_lymphatic_vessel0.59957905
142MP0001502_abnormal_circadian_rhythm0.59874608
143MP0002168_other_aberrant_phenotype0.58369656
144MP0000470_abnormal_stomach_morphology0.56408215
145MP0002928_abnormal_bile_duct0.56161355

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.83062909
2Chromsome breakage (HP:0040012)6.25073687
3Chronic otitis media (HP:0000389)4.28587917
4Retrobulbar optic neuritis (HP:0100654)3.92674193
5Optic neuritis (HP:0100653)3.92674193
6Recurrent abscess formation (HP:0002722)3.75029693
7T lymphocytopenia (HP:0005403)3.55939044
8Aplasia/Hypoplasia of the uvula (HP:0010293)3.49497829
9Spontaneous hematomas (HP:0007420)3.42351392
10Abnormality of the preputium (HP:0100587)3.42232131
11Clubbing of toes (HP:0100760)3.40753474
12Meckel diverticulum (HP:0002245)3.38142569
13Orchitis (HP:0100796)3.38121958
14Abnormality of chromosome stability (HP:0003220)3.36657004
15Abnormality of T cell number (HP:0011839)3.33797065
16Myositis (HP:0100614)3.24114441
17Abnormality of the ileum (HP:0001549)3.23181630
18Hemoptysis (HP:0002105)3.20248494
19Aplastic anemia (HP:0001915)3.13469290
20Recurrent bacterial skin infections (HP:0005406)3.11353878
21Eczematoid dermatitis (HP:0000976)3.08949397
22Mediastinal lymphadenopathy (HP:0100721)2.95559278
23Prostate neoplasm (HP:0100787)2.94827380
24Absent rod-and cone-mediated responses on ERG (HP:0007688)2.84776843
25Gastrointestinal infarctions (HP:0005244)2.80489556
26Ectopic kidney (HP:0000086)2.75910699
27Hemiplegia (HP:0002301)2.68937261
28Arterial thrombosis (HP:0004420)2.68921226
29Recurrent bronchitis (HP:0002837)2.62149523
30Leukocytosis (HP:0001974)2.60389994
31Type I transferrin isoform profile (HP:0003642)2.59141062
32Pulmonary embolism (HP:0002204)2.57178745
33Abnormality of the renal cortex (HP:0011035)2.56915879
34Myelodysplasia (HP:0002863)2.54430040
35Abnormality of the renal collecting system (HP:0004742)2.52895624
36Duplicated collecting system (HP:0000081)2.48988813
37Chest pain (HP:0100749)2.46471579
38Abnormality of T cells (HP:0002843)2.45875961
39Abnormality of the fingertips (HP:0001211)2.42425544
40Nephroblastoma (Wilms tumor) (HP:0002667)2.41995056
41Abnormality of eosinophils (HP:0001879)2.41455344
42Reduced antithrombin III activity (HP:0001976)2.39595722
43Chronic mucocutaneous candidiasis (HP:0002728)2.38643896
44Recurrent cutaneous fungal infections (HP:0011370)2.38643896
45Panhypogammaglobulinemia (HP:0003139)2.38382361
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.34460706
47Meningitis (HP:0001287)2.32876841
48True hermaphroditism (HP:0010459)2.32510864
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.32280505
50Bone marrow hypocellularity (HP:0005528)2.31830054
51Thyroiditis (HP:0100646)2.30959938
52Abnormal rod and cone electroretinograms (HP:0008323)2.30893877
53Prolonged bleeding time (HP:0003010)2.30675952
54Recurrent fungal infections (HP:0002841)2.30205854
55Increased cerebral lipofuscin (HP:0011813)2.29836158
56Duodenal stenosis (HP:0100867)2.29319264
57Small intestinal stenosis (HP:0012848)2.29319264
58Abolished electroretinogram (ERG) (HP:0000550)2.29021536
59Hematochezia (HP:0002573)2.27238039
60Renal cortical cysts (HP:0000803)2.27104971
61Keratoconjunctivitis sicca (HP:0001097)2.24449338
62Obstructive lung disease (HP:0006536)2.24425162
63Chronic obstructive pulmonary disease (HP:0006510)2.24425162
64Embryonal renal neoplasm (HP:0011794)2.23992865
65Abnormality of the carotid arteries (HP:0005344)2.22451538
66Microcytic anemia (HP:0001935)2.22167219
67Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.20946941
68Stomach cancer (HP:0012126)2.20182606
69Chronic hepatic failure (HP:0100626)2.18559205
70Asymmetry of the thorax (HP:0001555)2.17759964
71Gingival bleeding (HP:0000225)2.16934783
72Abnormal hair whorl (HP:0010721)2.15556742
73Attenuation of retinal blood vessels (HP:0007843)2.14498329
74Vasculitis (HP:0002633)2.14335550
75Abnormality of the pleura (HP:0002103)2.14045351
76Epistaxis (HP:0000421)2.12360655
77Natal tooth (HP:0000695)2.12089055
78Abnormality of DNA repair (HP:0003254)2.10754773
79Eosinophilia (HP:0001880)2.09457394
80Stomatitis (HP:0010280)2.09070508
81Abnormality of the prostate (HP:0008775)2.07324330
82Hypochromic microcytic anemia (HP:0004840)2.06943218
83Basal ganglia calcification (HP:0002135)2.06733842
84Elevated erythrocyte sedimentation rate (HP:0003565)2.05242890
85Pancreatic cysts (HP:0001737)2.05136954
86Decreased electroretinogram (ERG) amplitude (HP:0000654)2.04359691
87Urethral obstruction (HP:0000796)2.03981394
88Recurrent pneumonia (HP:0006532)2.03971631
89Pustule (HP:0200039)2.03141996
90Petechiae (HP:0000967)2.01264193
91Protruding tongue (HP:0010808)2.01065548
92Keratoconjunctivitis (HP:0001096)2.00933004
93Chronic sinusitis (HP:0011109)2.00756583
94Neoplasm of the tracheobronchial system (HP:0100552)2.00083688
95Nasal polyposis (HP:0100582)1.99675766
96Abnormality of macrophages (HP:0004311)1.98970460
97Recurrent skin infections (HP:0001581)1.98966440
98Cheilitis (HP:0100825)1.98842371
99Congenital stationary night blindness (HP:0007642)1.98590877
100Birth length less than 3rd percentile (HP:0003561)1.98461214
101Hyperventilation (HP:0002883)1.97812965
102Recurrent viral infections (HP:0004429)1.97305264
103Gingivitis (HP:0000230)1.96786884
104Congenital sensorineural hearing impairment (HP:0008527)1.96155145
105Abnormality of incisor morphology (HP:0011063)1.95403462
106Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94848931
107Pulmonary infiltrates (HP:0002113)1.93792030
108Chronic diarrhea (HP:0002028)1.93434705
109Generalized hypopigmentation of hair (HP:0011358)1.93098033
110Xerostomia (HP:0000217)1.92217134
111White forelock (HP:0002211)1.90825431
112Hypoplasia of the thymus (HP:0000778)1.88247598
113Granulocytopenia (HP:0001913)1.87957919
114Vertigo (HP:0002321)1.87073569
115Abnormality of the renal medulla (HP:0100957)1.86936875
116Vacuolated lymphocytes (HP:0001922)1.86902450
117Anal stenosis (HP:0002025)1.86750860
118Abnormality of the nasal mucosa (HP:0000433)1.86361258
119Abnormality of T cell physiology (HP:0011840)1.85654172
120Albinism (HP:0001022)1.85207782
121Syringomyelia (HP:0003396)1.85103677
122Spinal cord lesions (HP:0100561)1.85103677
123Gangrene (HP:0100758)1.84805657
124Anorexia (HP:0002039)1.84108001
125Encephalitis (HP:0002383)1.83279128
126Oligohydramnios (HP:0001562)1.83207137
127Viral hepatitis (HP:0006562)1.83073467
128Polydipsia (HP:0001959)1.82603427
129Abnormal drinking behavior (HP:0030082)1.82603427
130Abnormality of the endocardium (HP:0004306)1.82500486
131Febrile seizures (HP:0002373)1.82412147
132Abnormality of the columella (HP:0009929)1.82391210
133Abnormality of the duodenum (HP:0002246)1.81957908
134Glomerulopathy (HP:0100820)1.81803731
135Pancreatic fibrosis (HP:0100732)1.81082932
136IgM deficiency (HP:0002850)1.80766713
137Short thumb (HP:0009778)1.80229590
138Hypergonadotropic hypogonadism (HP:0000815)1.80140409
139Leukopenia (HP:0001882)1.79317140
140Embryonal neoplasm (HP:0002898)1.79112555
141Decreased central vision (HP:0007663)1.78385765
142Peritonitis (HP:0002586)1.78200885
143Keratitis (HP:0000491)1.77815490
144Abnormality of transition element cation homeostasis (HP:0011030)1.77108451
145Recurrent gram-negative bacterial infections (HP:0005420)1.77013031
146Keratoconus (HP:0000563)1.76766657
147Increased corneal curvature (HP:0100692)1.76766657
148Abnormal biliary tract physiology (HP:0012439)1.76692676
149Bile duct proliferation (HP:0001408)1.76692676
150Nephronophthisis (HP:0000090)1.76451559
151Alveolar cell carcinoma (HP:0006519)1.76432160
152Autoimmune thrombocytopenia (HP:0001973)1.75776976
153Abnormality of macular pigmentation (HP:0008002)1.75656139
154Anomalous pulmonary venous return (HP:0010772)1.74872861
155Patchy hypopigmentation of hair (HP:0011365)1.72743669
156Acute myeloid leukemia (HP:0004808)1.70763555
157Fair hair (HP:0002286)1.70296184
158Increased IgM level (HP:0003496)1.67482789
159Duplication of thumb phalanx (HP:0009942)1.67261527
160Sloping forehead (HP:0000340)1.66752538
161Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.66744628
162Abnormal protein N-linked glycosylation (HP:0012347)1.66744628
163Abnormal protein glycosylation (HP:0012346)1.66744628
164Abnormal glycosylation (HP:0012345)1.66744628
165Hypoplasia of the fovea (HP:0007750)1.66326453
166Aplasia/Hypoplasia of the fovea (HP:0008060)1.66326453
167Fibular hypoplasia (HP:0003038)1.64896876

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.37275622
2FRK3.73792117
3IRAK43.32948826
4TXK3.22241607
5ZAK3.18750898
6MAP3K142.89479897
7CASK2.80090766
8FES2.71097340
9SIK32.23893240
10EIF2AK21.98085558
11YES11.97894918
12ERBB31.86708491
13TEC1.84319214
14ADRBK21.69505954
15BMPR21.66452026
16TNK21.65065093
17SGK21.63426412
18TLK11.62399316
19KIT1.61385934
20INSRR1.57572555
21MAP4K11.57119091
22NUAK11.53897421
23ITK1.51040975
24BMPR1B1.50914650
25STK241.50015837
26PIK3CG1.48235024
27JAK31.46177017
28IKBKB1.46100269
29MAP2K71.39112750
30BTK1.38810636
31MKNK21.36365451
32CDK81.35510689
33PLK41.33809533
34STK38L1.32770986
35MAP2K31.32477133
36AKT31.28568755
37PRPF4B1.27220862
38SRPK11.25820401
39IRAK11.25339990
40GRK61.25120585
41TGFBR21.24463476
42IKBKE1.23622186
43TRPM71.19498351
44MOS1.19463366
45CHUK1.17605059
46JAK21.16358425
47CDK31.13922997
48HCK1.09425329
49VRK11.08877490
50CLK11.07695745
51GRK71.03106137
52MARK31.02442036
53MUSK1.02404230
54ACVR1B1.02200221
55NEK61.01763664
56PTK2B1.01622373
57JAK11.00293417
58ATR0.99816226
59CAMK1D0.99815963
60TAOK30.99720810
61MAP3K130.99320120
62STK160.99267376
63FGR0.97979107
64CSF1R0.95984835
65NLK0.95287926
66BLK0.95201458
67EPHA30.94389738
68SGK30.93665623
69TIE10.91741235
70IRAK20.91062899
71LYN0.90947286
72STK100.88238911
73WNK10.86738736
74ADRBK10.86213847
75MKNK10.84845594
76GRK50.82437188
77FLT30.82119580
78PRKCQ0.80467196
79TTK0.80458438
80TYK20.79319401
81PDK10.78013461
82SYK0.77492199
83PAK30.76531238
84GRK10.76314808
85BRD40.72160220
86ZAP700.70588095
87LCK0.70143715
88MAP3K70.68826282
89RIPK40.67797902
90MAPK70.66470187
91MATK0.66359531
92TBK10.65859132
93SGK2230.65496848
94SGK4940.65496848
95WNK40.64409808
96MAPK120.64096950
97MAPK130.63406590
98PIM10.63385206
99TAOK20.62640011
100SIK20.62376998
101CAMK40.62106184
102STK40.61847189
103FGFR30.60941266
104STK110.60623527
105DAPK20.57849647
106ERBB20.56795450
107TNIK0.54935011
108NEK90.53691218
109MAP4K20.53619023
110ABL10.52798952
111EPHB10.51910670
112PRKAA20.51909624
113CAMK1G0.51546038
114MAP3K30.49660213
115RPS6KA60.49558996
116CSK0.49088217
117SGK10.48348603
118KDR0.48102091
119IGF1R0.47397589
120MARK20.46825398
121STK30.46336842
122CDK70.46096018
123CDK90.45775787
124PKN10.45727316
125MAP3K10.45620705
126PRKCD0.45053096
127EGFR0.44969819
128HIPK20.43941894
129STK380.43757865
130CAMK10.43602209
131CCNB10.43497896
132PRKCE0.42046582
133RPS6KL10.41421242
134RPS6KC10.41421242
135MAP3K40.40787007
136PDGFRB0.40492364
137MELK0.40269267
138PIK3CA0.40013880
139OBSCN0.39951755
140PINK10.39107994
141PLK20.38604496
142AKT10.37475455
143PIM20.37328336
144CHEK20.36986294
145ATM0.35148546
146CAMKK20.34818419
147EIF2AK30.34771479

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.06696860
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.55467430
3Graft-versus-host disease_Homo sapiens_hsa053322.48073028
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.36503911
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.25437057
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.24000561
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.09761374
8Homologous recombination_Homo sapiens_hsa034402.08280399
9Allograft rejection_Homo sapiens_hsa053302.04140846
10Measles_Homo sapiens_hsa051621.98848145
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.87791413
12Leishmaniasis_Homo sapiens_hsa051401.84439448
13Other glycan degradation_Homo sapiens_hsa005111.81245474
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.74703392
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73112858
16Non-homologous end-joining_Homo sapiens_hsa034501.72423851
17Hematopoietic cell lineage_Homo sapiens_hsa046401.69246341
18Base excision repair_Homo sapiens_hsa034101.68929218
19Autoimmune thyroid disease_Homo sapiens_hsa053201.67858774
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58393882
21Herpes simplex infection_Homo sapiens_hsa051681.57753609
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56016262
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.51906405
24Malaria_Homo sapiens_hsa051441.50357003
25Platelet activation_Homo sapiens_hsa046111.47406693
26Primary immunodeficiency_Homo sapiens_hsa053401.43559540
27Mismatch repair_Homo sapiens_hsa034301.38682206
28TNF signaling pathway_Homo sapiens_hsa046681.37763571
29DNA replication_Homo sapiens_hsa030301.36837964
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33794158
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.32536358
32Influenza A_Homo sapiens_hsa051641.29406287
33Rheumatoid arthritis_Homo sapiens_hsa053231.29401301
34Dorso-ventral axis formation_Homo sapiens_hsa043201.27847786
35Osteoclast differentiation_Homo sapiens_hsa043801.27153113
36Basal transcription factors_Homo sapiens_hsa030221.27026159
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.23863190
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22502811
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22171505
40Type I diabetes mellitus_Homo sapiens_hsa049401.21365898
41Asthma_Homo sapiens_hsa053101.20212062
42Tuberculosis_Homo sapiens_hsa051521.18155818
43Pertussis_Homo sapiens_hsa051331.13213218
44Legionellosis_Homo sapiens_hsa051341.11553767
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05778286
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01212700
47Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99487038
48Arachidonic acid metabolism_Homo sapiens_hsa005900.98910296
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98499066
50Linoleic acid metabolism_Homo sapiens_hsa005910.98176150
51Hepatitis B_Homo sapiens_hsa051610.94736282
52Renin secretion_Homo sapiens_hsa049240.93946379
53Salivary secretion_Homo sapiens_hsa049700.93278271
54Chemokine signaling pathway_Homo sapiens_hsa040620.93108568
55One carbon pool by folate_Homo sapiens_hsa006700.92599921
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92299542
57Ether lipid metabolism_Homo sapiens_hsa005650.92107072
58Staphylococcus aureus infection_Homo sapiens_hsa051500.91564202
59RNA degradation_Homo sapiens_hsa030180.90914587
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90748266
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89785071
62Cell cycle_Homo sapiens_hsa041100.84195064
63Apoptosis_Homo sapiens_hsa042100.83603933
64Sphingolipid metabolism_Homo sapiens_hsa006000.80323170
65African trypanosomiasis_Homo sapiens_hsa051430.80272046
66Notch signaling pathway_Homo sapiens_hsa043300.79915305
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78270501
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.78179552
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77353962
70Phagosome_Homo sapiens_hsa041450.77071589
71B cell receptor signaling pathway_Homo sapiens_hsa046620.76493357
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.73336314
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72488610
74Toxoplasmosis_Homo sapiens_hsa051450.72269707
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71726255
76Long-term depression_Homo sapiens_hsa047300.71624518
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70500100
78Morphine addiction_Homo sapiens_hsa050320.69998142
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69533528
80Pyrimidine metabolism_Homo sapiens_hsa002400.69161854
81Nucleotide excision repair_Homo sapiens_hsa034200.69126148
82p53 signaling pathway_Homo sapiens_hsa041150.68779860
83Complement and coagulation cascades_Homo sapiens_hsa046100.67254383
84Oxytocin signaling pathway_Homo sapiens_hsa049210.66724117
85Circadian entrainment_Homo sapiens_hsa047130.66428376
86Epstein-Barr virus infection_Homo sapiens_hsa051690.63743998
87Gastric acid secretion_Homo sapiens_hsa049710.63649942
88Vitamin digestion and absorption_Homo sapiens_hsa049770.63535028
89Antigen processing and presentation_Homo sapiens_hsa046120.63529283
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62968716
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62807097
92Olfactory transduction_Homo sapiens_hsa047400.62736834
93Regulation of autophagy_Homo sapiens_hsa041400.62572043
94Phototransduction_Homo sapiens_hsa047440.62229108
95FoxO signaling pathway_Homo sapiens_hsa040680.61980197
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.61546021
97Hepatitis C_Homo sapiens_hsa051600.60910953
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60905024
99Viral myocarditis_Homo sapiens_hsa054160.60176084
100Glutamatergic synapse_Homo sapiens_hsa047240.60065306
101Calcium signaling pathway_Homo sapiens_hsa040200.59286369
102Taste transduction_Homo sapiens_hsa047420.58607158
103Lysosome_Homo sapiens_hsa041420.57789347
104Inositol phosphate metabolism_Homo sapiens_hsa005620.57532741
105cAMP signaling pathway_Homo sapiens_hsa040240.57100547
106Systemic lupus erythematosus_Homo sapiens_hsa053220.56647730
107Cholinergic synapse_Homo sapiens_hsa047250.56525668
108HTLV-I infection_Homo sapiens_hsa051660.56336265
109Purine metabolism_Homo sapiens_hsa002300.53072389
110GnRH signaling pathway_Homo sapiens_hsa049120.52893231
111T cell receptor signaling pathway_Homo sapiens_hsa046600.52577426
112Salmonella infection_Homo sapiens_hsa051320.52303030
113Ovarian steroidogenesis_Homo sapiens_hsa049130.51945465
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50994019
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50288655
116Ras signaling pathway_Homo sapiens_hsa040140.50255432
117Nitrogen metabolism_Homo sapiens_hsa009100.50020277
118Non-small cell lung cancer_Homo sapiens_hsa052230.49256488
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.48695662
120MAPK signaling pathway_Homo sapiens_hsa040100.48276660
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47643046
122Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46775518
123Rap1 signaling pathway_Homo sapiens_hsa040150.45725281
124Serotonergic synapse_Homo sapiens_hsa047260.45406564
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43148352
126MicroRNAs in cancer_Homo sapiens_hsa052060.41890875
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41868284
128Prolactin signaling pathway_Homo sapiens_hsa049170.39851581
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37619318
130Acute myeloid leukemia_Homo sapiens_hsa052210.37485968
131ABC transporters_Homo sapiens_hsa020100.34802100
132Pathways in cancer_Homo sapiens_hsa052000.34540623
133Shigellosis_Homo sapiens_hsa051310.34216330
134Small cell lung cancer_Homo sapiens_hsa052220.34069328
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33998170
136Melanoma_Homo sapiens_hsa052180.32682715
137Viral carcinogenesis_Homo sapiens_hsa052030.30544354
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.30306390
139RNA polymerase_Homo sapiens_hsa030200.29869852

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