DISP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.03516005
2positive regulation of cell size (GO:0045793)4.79723467
3negative regulation of neurotransmitter transport (GO:0051589)4.73479670
4response to lipoprotein particle (GO:0055094)4.72331616
5arginine catabolic process (GO:0006527)4.67082861
6exogenous drug catabolic process (GO:0042738)4.66224694
7chondrocyte proliferation (GO:0035988)4.51613986
8drug catabolic process (GO:0042737)4.12143031
9collagen fibril organization (GO:0030199)4.11061193
10arginine metabolic process (GO:0006525)4.11058118
11negative regulation of vascular permeability (GO:0043116)3.99550707
12cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.92236527
13regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.74025269
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.72716841
15protein localization to kinetochore (GO:0034501)3.68310328
16negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.66245873
17sodium-independent organic anion transport (GO:0043252)3.45643614
18endodermal cell differentiation (GO:0035987)3.45379900
19regulation of neurotransmitter uptake (GO:0051580)3.40072908
20protein heterotrimerization (GO:0070208)3.39892322
21positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.37233357
22regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.36731319
23epithelial cilium movement (GO:0003351)3.33777305
24notochord development (GO:0030903)3.31879003
25nuclear pore complex assembly (GO:0051292)3.30283085
26negative regulation of calcium ion transport into cytosol (GO:0010523)3.28515478
27lateral sprouting from an epithelium (GO:0060601)3.23697212
28regulation of nuclear cell cycle DNA replication (GO:0033262)3.22914570
29bone trabecula formation (GO:0060346)3.18462658
30paraxial mesoderm development (GO:0048339)3.18059768
31nonmotile primary cilium assembly (GO:0035058)3.17758505
32somite development (GO:0061053)3.16421434
33regulation of cilium movement (GO:0003352)3.15496630
34positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.13082318
35mitotic chromosome condensation (GO:0007076)3.12599149
36negative regulation of macrophage differentiation (GO:0045650)3.09953734
37positive regulation of guanylate cyclase activity (GO:0031284)3.05869146
38cell migration involved in heart development (GO:0060973)3.04650207
39respiratory chain complex IV assembly (GO:0008535)3.02513924
40basement membrane organization (GO:0071711)3.00375725
41nuclear pore organization (GO:0006999)3.00287272
42negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.97683863
43regulation of mitotic spindle organization (GO:0060236)2.97347037
44mitotic nuclear envelope disassembly (GO:0007077)2.96445610
45neurotransmitter biosynthetic process (GO:0042136)2.96056641
46protein localization to chromosome, centromeric region (GO:0071459)2.94144326
47skin morphogenesis (GO:0043589)2.91964606
48positive regulation of epithelial to mesenchymal transition (GO:0010718)2.91120629
49embryonic skeletal joint morphogenesis (GO:0060272)2.86047705
50regulation of spindle organization (GO:0090224)2.85772382
51glomerular basement membrane development (GO:0032836)2.85296684
52nitric oxide mediated signal transduction (GO:0007263)2.84039209
53epithelial cell-cell adhesion (GO:0090136)2.82921042
54hippo signaling (GO:0035329)2.82526656
55membrane disassembly (GO:0030397)2.77488204
56nuclear envelope disassembly (GO:0051081)2.77488204
57chondrocyte development (GO:0002063)2.77354323
58DNA unwinding involved in DNA replication (GO:0006268)2.76845452
59heterochromatin organization (GO:0070828)2.75315836
60mitotic sister chromatid cohesion (GO:0007064)2.75144608
61neuron projection extension involved in neuron projection guidance (GO:1902284)2.74952085
62axon extension involved in axon guidance (GO:0048846)2.74952085
63planar cell polarity pathway involved in neural tube closure (GO:0090179)2.74749594
64positive regulation of sodium ion transmembrane transport (GO:1902307)2.73937886
65myoblast fusion (GO:0007520)2.73835082
66prostate gland growth (GO:0060736)2.73030948
67regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.71729937
68axonal fasciculation (GO:0007413)2.70275288
69regulation of SMAD protein import into nucleus (GO:0060390)2.70231512
70regulation of heart morphogenesis (GO:2000826)2.69800498
71COPI coating of Golgi vesicle (GO:0048205)2.67349563
72Golgi transport vesicle coating (GO:0048200)2.67349563
73outer ear morphogenesis (GO:0042473)2.67245599
74regulation of guanylate cyclase activity (GO:0031282)2.65930042
75metanephric mesenchyme development (GO:0072075)2.65485656
76mesenchymal cell differentiation involved in renal system development (GO:2001012)2.65280544
77mesenchymal cell differentiation involved in kidney development (GO:0072161)2.65280544
78substrate-independent telencephalic tangential migration (GO:0021826)2.64968347
79substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.64968347
80dentate gyrus development (GO:0021542)2.63644232
81endocardial cushion development (GO:0003197)2.62021454
82negative regulation of cytosolic calcium ion concentration (GO:0051481)2.61728785
83positive regulation of cGMP biosynthetic process (GO:0030828)2.61207506
84presynaptic membrane assembly (GO:0097105)2.60410627
85prenylation (GO:0097354)2.60255271
86protein prenylation (GO:0018342)2.60255271
87regulation of sequestering of triglyceride (GO:0010889)2.60248583
88cellular protein complex localization (GO:0034629)2.59590106
89embryonic viscerocranium morphogenesis (GO:0048703)2.58579022
90regulation of non-canonical Wnt signaling pathway (GO:2000050)2.57944717
91regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.57403133
92glucocorticoid receptor signaling pathway (GO:0042921)2.57398974
93mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.56136339
94negative regulation of protein kinase B signaling (GO:0051898)2.55738571
95regulation of stem cell maintenance (GO:2000036)2.55459627
96cilium movement (GO:0003341)2.54493355
97establishment of protein localization to Golgi (GO:0072600)2.54269389
98kidney mesenchyme development (GO:0072074)2.52226321
99* determination of left/right symmetry (GO:0007368)2.51836928
100collagen metabolic process (GO:0032963)2.51611659
101lung vasculature development (GO:0060426)2.51240410
102photoreceptor cell maintenance (GO:0045494)2.50755406
103limb bud formation (GO:0060174)2.50537391
104positive regulation of SMAD protein import into nucleus (GO:0060391)2.49903860
105negative regulation of chondrocyte differentiation (GO:0032331)2.49556873
106negative regulation of fatty acid transport (GO:2000192)2.48614214
107artery smooth muscle contraction (GO:0014824)2.48256375
108* determination of bilateral symmetry (GO:0009855)2.47777674
109* specification of symmetry (GO:0009799)2.47560361
110positive regulation of cGMP metabolic process (GO:0030825)2.47147464
111collagen catabolic process (GO:0030574)2.47077865
112keratan sulfate catabolic process (GO:0042340)2.47068437
113dosage compensation (GO:0007549)2.46590583
114atrial septum morphogenesis (GO:0060413)2.45996357
115peptidyl-proline hydroxylation (GO:0019511)2.45209139
116pore complex assembly (GO:0046931)2.45144708
117regulation of transforming growth factor beta2 production (GO:0032909)2.45142874
118regulation of translational fidelity (GO:0006450)2.44477120
119wound healing, spreading of epidermal cells (GO:0035313)2.43959390
120protein localization to Golgi apparatus (GO:0034067)2.43157661
121protein targeting to Golgi (GO:0000042)2.42484691
122protein hydroxylation (GO:0018126)2.40854327
123regulation of tight junction assembly (GO:2000810)2.40118975
124sulfation (GO:0051923)2.40114197
125axonemal dynein complex assembly (GO:0070286)2.38739936
126negative regulation of potassium ion transport (GO:0043267)2.38582201
127negative regulation of DNA repair (GO:0045738)2.38439984
128regulation of cGMP biosynthetic process (GO:0030826)2.38333422
129cell adhesion mediated by integrin (GO:0033627)2.38333060
130negative regulation of hormone biosynthetic process (GO:0032353)2.38081443
131positive regulation of gastrulation (GO:2000543)2.36970677
132kidney morphogenesis (GO:0060993)2.36967944
133positive regulation of embryonic development (GO:0040019)2.36456220
134protein localization to chromosome (GO:0034502)2.36411524
135regulation of mitochondrial translation (GO:0070129)2.36278470
136regulation of axon guidance (GO:1902667)2.35059584
137cell proliferation involved in metanephros development (GO:0072203)2.34557140
138positive regulation of stem cell differentiation (GO:2000738)2.34342256
139positive regulation of extracellular matrix organization (GO:1903055)2.34259190
140regulation of cartilage development (GO:0061035)2.32687858
141regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.32339966
142positive regulation of transcription regulatory region DNA binding (GO:2000679)2.31927831
143sister chromatid segregation (GO:0000819)2.31885135
144sequestering of extracellular ligand from receptor (GO:0035581)2.31780057
145presynaptic membrane organization (GO:0097090)2.31601717
146positive regulation of blood vessel endothelial cell migration (GO:0043536)2.31468336
147regulation of cGMP metabolic process (GO:0030823)2.30922335
148multicellular organismal macromolecule metabolic process (GO:0044259)2.30799432
149regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.30470508
150exocrine pancreas development (GO:0031017)2.30071508
151positive regulation of glycolytic process (GO:0045821)2.29701725
152extracellular matrix disassembly (GO:0022617)2.29155328
153dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.29053613
154regulation of secondary heart field cardioblast proliferation (GO:0003266)2.29007370
155regulation of cardioblast proliferation (GO:0003264)2.29007370
156regulation of female gonad development (GO:2000194)2.28867572
157cytochrome complex assembly (GO:0017004)2.28766088
158peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.28682867
159atrioventricular valve morphogenesis (GO:0003181)2.27886214
160retrograde transport, vesicle recycling within Golgi (GO:0000301)2.27692397
161establishment of tissue polarity (GO:0007164)2.27549701
162establishment of planar polarity (GO:0001736)2.27549701
163branching involved in prostate gland morphogenesis (GO:0060442)2.27438647
164tonic smooth muscle contraction (GO:0014820)2.26536846
165type B pancreatic cell development (GO:0003323)2.26506642
166nuclear envelope organization (GO:0006998)2.26332444
167oogenesis (GO:0048477)2.26266522
168regulation of male gonad development (GO:2000018)2.25956174
169mitotic metaphase plate congression (GO:0007080)2.25877422
170nitric oxide biosynthetic process (GO:0006809)2.24913859
171negative regulation of alcohol biosynthetic process (GO:1902931)2.24434283
172positive regulation of signal transduction by p53 class mediator (GO:1901798)2.24367290
173multicellular organismal catabolic process (GO:0044243)2.24264509
174cell-substrate junction assembly (GO:0007044)2.24227795
175negative regulation of cartilage development (GO:0061037)2.23770333
176prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.23738892
177plasma membrane repair (GO:0001778)2.23642996
178regulation of organ formation (GO:0003156)2.22509717
179cell aggregation (GO:0098743)2.21788601
180cartilage condensation (GO:0001502)2.21788601
181regulation of chondrocyte differentiation (GO:0032330)2.21723868
182regulation of endothelial cell differentiation (GO:0045601)2.21281258
183regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.21116966
184mesenchymal cell differentiation (GO:0048762)2.20966646
185positive regulation of catecholamine secretion (GO:0033605)2.20538523
186substrate adhesion-dependent cell spreading (GO:0034446)2.20106526
187inner ear receptor stereocilium organization (GO:0060122)2.19849227
188regulation of hippo signaling (GO:0035330)2.19725757
189corticosteroid receptor signaling pathway (GO:0031958)2.19161861
190vascular smooth muscle contraction (GO:0014829)2.18915007
191wound healing, spreading of cells (GO:0044319)2.17605918
192adherens junction assembly (GO:0034333)2.17428260
193positive regulation of endothelial cell apoptotic process (GO:2000353)2.17375158
194mesonephric tubule development (GO:0072164)2.17229743
195detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.17118578
196negative regulation of DNA-dependent DNA replication (GO:2000104)2.17071718
197platelet-derived growth factor receptor signaling pathway (GO:0048008)2.17033018
198germ cell migration (GO:0008354)2.16619857
199negative regulation of activin receptor signaling pathway (GO:0032926)2.16305949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.24358530
2E2F7_22180533_ChIP-Seq_HELA_Human5.46984763
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.78921141
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.07492718
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.94725347
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.30217787
7MYC_22102868_ChIP-Seq_BL_Human2.69017826
8GBX2_23144817_ChIP-Seq_PC3_Human2.64166546
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.63684896
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.61988558
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.60601477
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.54245235
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41572013
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.38769253
15* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.34406204
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29482481
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.27127727
18ZNF274_21170338_ChIP-Seq_K562_Hela2.23943344
19RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.22523785
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19728018
21AR_21909140_ChIP-Seq_LNCAP_Human2.15946208
22* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10976231
23PIAS1_25552417_ChIP-Seq_VCAP_Human2.09944344
24TAF15_26573619_Chip-Seq_HEK293_Human2.08640299
25ELK3_25401928_ChIP-Seq_HUVEC_Human2.04825522
26CLOCK_20551151_ChIP-Seq_293T_Human2.03155438
27* FUS_26573619_Chip-Seq_HEK293_Human2.02789228
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.95023396
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92215535
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89812734
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87116359
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85545546
33EWS_26573619_Chip-Seq_HEK293_Human1.84695721
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82611836
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.82558457
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.82280647
37SMAD4_21799915_ChIP-Seq_A2780_Human1.81165860
38* P300_19829295_ChIP-Seq_ESCs_Human1.79957985
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.79122470
40VDR_22108803_ChIP-Seq_LS180_Human1.78203825
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77876272
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.75413851
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74342384
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.73909084
45VDR_21846776_ChIP-Seq_THP-1_Human1.73432913
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72806972
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67314047
48TCF7_22412390_ChIP-Seq_EML_Mouse1.65745093
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.65197014
50* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.64664840
51AR_25329375_ChIP-Seq_VCAP_Human1.63507041
52TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.63461244
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63141968
54BCAT_22108803_ChIP-Seq_LS180_Human1.61790228
55KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.61479782
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60551432
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.60038618
58ATF3_27146783_Chip-Seq_COLON_Human1.58830116
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.58427816
60* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57893004
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57661061
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56930626
63STAT3_23295773_ChIP-Seq_U87_Human1.56469961
64* SMAD3_21741376_ChIP-Seq_EPCs_Human1.56365454
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55542089
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55187581
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54916453
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54852749
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54177000
70* BRD4_25478319_ChIP-Seq_HGPS_Human1.53812078
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.53458372
72KDM2B_26808549_Chip-Seq_DND41_Human1.52055659
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51913933
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51026396
75EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50715272
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48601178
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.46445618
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45572074
79XRN2_22483619_ChIP-Seq_HELA_Human1.44924719
80SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44567225
81AHR_22903824_ChIP-Seq_MCF-7_Human1.44031788
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43603679
83RNF2_27304074_Chip-Seq_NSC_Mouse1.43570487
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43255873
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42523892
86STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.42079599
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41508674
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41416177
89FLI1_27457419_Chip-Seq_LIVER_Mouse1.41310235
90JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40992559
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39605645
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39558662
93CBP_20019798_ChIP-Seq_JUKART_Human1.39558662
94* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38962462
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.38905745
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36554127
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.36357976
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36303880
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.35318786
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34911243
101TP53_22127205_ChIP-Seq_IMR90_Human1.32675483
102* TCF4_23295773_ChIP-Seq_U87_Human1.31566689
103TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.31441980
104DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.31179896
105SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31050735
106CIITA_25753668_ChIP-Seq_RAJI_Human1.30776897
107NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.30494432
108CJUN_26792858_Chip-Seq_BT549_Human1.29529801
109CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.29328990
110PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29321079
111* TCF4_22108803_ChIP-Seq_LS180_Human1.29055218
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28381339
113SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27930520
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27552265
115MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27244873
116KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27090325
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26664612
118SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26098374
119EP300_21415370_ChIP-Seq_HL-1_Mouse1.24929588
120NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24402067
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24335801
122CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.23377651
123PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23211167
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23204875
125UTX_26944678_Chip-Seq_JUKART_Human1.23115898
126TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23051716
127* SMAD4_21741376_ChIP-Seq_EPCs_Human1.22069056
128RUNX2_22187159_ChIP-Seq_PCA_Human1.21358476
129FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21263706
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21187463
131SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21134159
132SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21134159
133NANOG_18555785_Chip-Seq_ESCs_Mouse1.20560513
134UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20211352
135UBF1/2_26484160_Chip-Seq_HMECs_Human1.19443247
136ER_23166858_ChIP-Seq_MCF-7_Human1.19401387
137ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19070983
138MAF_26560356_Chip-Seq_TH1_Human1.18854688
139HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18603504
140SOX2_21211035_ChIP-Seq_LN229_Gbm1.18293447
141AR_21572438_ChIP-Seq_LNCaP_Human1.18170179
142MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17714057
143MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.17645702
144TP53_16413492_ChIP-PET_HCT116_Human1.16988851
145TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16786844
146KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16419044
147TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14747123
148ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14647435
149EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13764962
150HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13711667
151ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13575852
152RACK7_27058665_Chip-Seq_MCF-7_Human1.13566318
153SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13404294
154CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13023569
155P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12999144
156PRDM14_20953172_ChIP-Seq_ESCs_Human1.11848377
157KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11425521
158FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.11339542
159JUN_21703547_ChIP-Seq_K562_Human1.11121013
160NCOR1_26117541_ChIP-Seq_K562_Human1.10582887
161CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10476320
162ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09892626
163MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09200706
164SALL1_21062744_ChIP-ChIP_HESCs_Human1.09092391
165KDM2B_26808549_Chip-Seq_JURKAT_Human1.08781185
166POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08723568
167TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08723568
168SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08582277
169TFEB_21752829_ChIP-Seq_HELA_Human1.08385845
170CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07939510
171MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07428309
172WT1_19549856_ChIP-ChIP_CCG9911_Human1.06857974
173NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06728041
174KDM2B_26808549_Chip-Seq_REH_Human1.06652496
175* CDX2_22108803_ChIP-Seq_LS180_Human1.06575522
176NFE2_27457419_Chip-Seq_LIVER_Mouse1.06390945
177ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06384216
178DROSHA_22980978_ChIP-Seq_HELA_Human1.06324807
179* SMAD3_21741376_ChIP-Seq_ESCs_Human1.05906603
180RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05490242
181EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05490242
182PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05406934
183CRX_20693478_ChIP-Seq_RETINA_Mouse1.04577029
184VDR_24763502_ChIP-Seq_THP-1_Human1.03155341
185TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03120181
186CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02708900
187TTF2_22483619_ChIP-Seq_HELA_Human1.02065418
188CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01790064
189BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01279869
190MYC_18358816_ChIP-ChIP_MESCs_Mouse1.00911635
191* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00425329
192STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99813127
193CHD1_26751641_Chip-Seq_LNCaP_Human0.99405569
194NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97638993
195SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96606144
196SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94775019
197KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92897048

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.18909223
2MP0003646_muscle_fatigue4.93877125
3MP0008438_abnormal_cutaneous_collagen4.13455308
4MP0005503_abnormal_tendon_morphology3.62138947
5MP0003705_abnormal_hypodermis_morpholog3.05008436
6MP0004043_abnormal_pH_regulation2.82863968
7MP0010030_abnormal_orbit_morphology2.64124200
8MP0005645_abnormal_hypothalamus_physiol2.51200457
9MP0005275_abnormal_skin_tensile2.46246673
10MP0003279_aneurysm2.40815709
11MP0005623_abnormal_meninges_morphology2.29288391
12MP0003123_paternal_imprinting2.22371960
13MP0010352_gastrointestinal_tract_polyps2.14410075
14MP0009053_abnormal_anal_canal2.13393546
15MP0005167_abnormal_blood-brain_barrier2.12163585
16MP0009250_abnormal_appendicular_skeleto1.96861586
17MP0003718_maternal_effect1.93335983
18MP0006054_spinal_hemorrhage1.93203003
19MP0003283_abnormal_digestive_organ1.87917088
20MP0003566_abnormal_cell_adhesion1.87616208
21MP0003942_abnormal_urinary_system1.87473585
22MP0005508_abnormal_skeleton_morphology1.81180060
23MP0003195_calcinosis1.80336030
24MP0004272_abnormal_basement_membrane1.79593306
25MP0005023_abnormal_wound_healing1.75147041
26MP0005076_abnormal_cell_differentiation1.74549771
27MP0002938_white_spotting1.72280411
28MP0005257_abnormal_intraocular_pressure1.71711242
29MP0009384_cardiac_valve_regurgitation1.71518489
30MP0004858_abnormal_nervous_system1.70696147
31MP0003385_abnormal_body_wall1.64749541
32MP0002933_joint_inflammation1.63933037
33MP0003121_genomic_imprinting1.63257611
34MP0001919_abnormal_reproductive_system1.56738804
35* MP0000733_abnormal_muscle_development1.56720024
36MP0008775_abnormal_heart_ventricle1.55796173
37MP0008007_abnormal_cellular_replicative1.53747676
38MP0004134_abnormal_chest_morphology1.53199385
39MP0002282_abnormal_trachea_morphology1.52187089
40MP0004808_abnormal_hematopoietic_stem1.50518352
41MP0002932_abnormal_joint_morphology1.49732547
42MP0004133_heterotaxia1.48373086
43MP0001501_abnormal_sleep_pattern1.47839057
44MP0000534_abnormal_ureter_morphology1.46835803
45MP0005187_abnormal_penis_morphology1.45628657
46* MP0002233_abnormal_nose_morphology1.44159591
47MP0003077_abnormal_cell_cycle1.39887795
48MP0009780_abnormal_chondrocyte_physiolo1.36538281
49MP0003111_abnormal_nucleus_morphology1.34128184
50MP0002115_abnormal_skeleton_extremities1.32091199
51MP0005646_abnormal_pituitary_gland1.32043713
52MP0001958_emphysema1.31280295
53* MP0000163_abnormal_cartilage_morphology1.31257717
54MP0000428_abnormal_craniofacial_morphol1.30823112
55* MP0002113_abnormal_skeleton_development1.30780139
56MP0002396_abnormal_hematopoietic_system1.30575623
57MP0008789_abnormal_olfactory_epithelium1.29930378
58MP0004197_abnormal_fetal_growth/weight/1.29712809
59MP0001764_abnormal_homeostasis1.29022939
60MP0005389_reproductive_system_phenotype1.27196765
61MP0003115_abnormal_respiratory_system1.24918735
62MP0003091_abnormal_cell_migration1.24601494
63MP0003937_abnormal_limbs/digits/tail_de1.23771655
64MP0002102_abnormal_ear_morphology1.21687365
65MP0000767_abnormal_smooth_muscle1.21376667
66MP0001915_intracranial_hemorrhage1.20710867
67MP0003693_abnormal_embryo_hatching1.19299798
68MP0004957_abnormal_blastocyst_morpholog1.17663508
69* MP0002109_abnormal_limb_morphology1.16932090
70MP0010094_abnormal_chromosome_stability1.16819387
71MP0010368_abnormal_lymphatic_system1.16582559
72MP0000049_abnormal_middle_ear1.16576458
73MP0009278_abnormal_bone_marrow1.16277647
74MP0002089_abnormal_postnatal_growth/wei1.16259139
75MP0002896_abnormal_bone_mineralization1.16116141
76MP0003755_abnormal_palate_morphology1.15851188
77MP0003122_maternal_imprinting1.15703649
78MP0001661_extended_life_span1.15481120
79MP0001849_ear_inflammation1.13102580
80MP0000350_abnormal_cell_proliferation1.11826104
81* MP0003935_abnormal_craniofacial_develop1.11350890
82MP0002060_abnormal_skin_morphology1.10742692
83MP0000569_abnormal_digit_pigmentation1.10479576
84MP0004233_abnormal_muscle_weight1.09994556
85MP0003880_abnormal_central_pattern1.09288582
86MP0005551_abnormal_eye_electrophysiolog1.08545219
87MP0005390_skeleton_phenotype1.08485810
88MP0001730_embryonic_growth_arrest1.08088729
89MP0000537_abnormal_urethra_morphology1.07823616
90MP0010386_abnormal_urinary_bladder1.07256035
91MP0002837_dystrophic_cardiac_calcinosis1.07185320
92MP0008872_abnormal_physiological_respon1.07181968
93MP0003984_embryonic_growth_retardation1.06415593
94MP0002108_abnormal_muscle_morphology1.05750392
95MP0001672_abnormal_embryogenesis/_devel1.05593251
96MP0005380_embryogenesis_phenotype1.05593251
97MP0002111_abnormal_tail_morphology1.05534889
98* MP0002084_abnormal_developmental_patter1.05326384
99MP0003567_abnormal_fetal_cardiomyocyte1.04665653
100MP0000383_abnormal_hair_follicle1.04453251
101MP0002088_abnormal_embryonic_growth/wei1.04220084
102* MP0002116_abnormal_craniofacial_bone1.03781675
103MP0001756_abnormal_urination1.03546123
104* MP0002085_abnormal_embryonic_tissue1.02939785
105* MP0000432_abnormal_head_morphology1.02697885
106MP0001243_abnormal_dermal_layer1.00979548
107MP0005171_absent_coat_pigmentation0.99903927
108* MP0001697_abnormal_embryo_size0.99612941
109MP0004084_abnormal_cardiac_muscle0.99580609
110MP0000751_myopathy0.99520070
111* MP0002925_abnormal_cardiovascular_devel0.98852874
112MP0004885_abnormal_endolymph0.98779832
113MP0001984_abnormal_olfaction0.98371444
114MP0001664_abnormal_digestion0.97203907
115MP0003941_abnormal_skin_development0.96197361
116MP0002127_abnormal_cardiovascular_syste0.93709462
117MP0003938_abnormal_ear_development0.93049595
118MP0002086_abnormal_extraembryonic_tissu0.92727104
119MP0004036_abnormal_muscle_relaxation0.92726949
120MP0000750_abnormal_muscle_regeneration0.92620129
121* MP0000631_abnormal_neuroendocrine_gland0.92386151
122MP0002114_abnormal_axial_skeleton0.91274184
123MP0000516_abnormal_urinary_system0.91173379
124MP0005367_renal/urinary_system_phenotyp0.91173379
125MP0008932_abnormal_embryonic_tissue0.90317326
126MP0006072_abnormal_retinal_apoptosis0.90001447
127MP0002249_abnormal_larynx_morphology0.89604472
128MP0003045_fibrosis0.89239707
129MP0002638_abnormal_pupillary_reflex0.89172096
130MP0006276_abnormal_autonomic_nervous0.89138656
131MP0001299_abnormal_eye_distance/0.89014964
132MP0005499_abnormal_olfactory_system0.88958601
133MP0005394_taste/olfaction_phenotype0.88958601
134MP0005332_abnormal_amino_acid0.87902454
135MP0000230_abnormal_systemic_arterial0.87008638
136MP0005085_abnormal_gallbladder_physiolo0.86405908
137MP0010630_abnormal_cardiac_muscle0.86284112
138MP0004145_abnormal_muscle_electrophysio0.85986919
139MP0000026_abnormal_inner_ear0.84920571
140MP0001542_abnormal_bone_strength0.84255458
141MP0000778_abnormal_nervous_system0.83741439
142MP0002128_abnormal_blood_circulation0.83733417
143MP0002009_preneoplasia0.83521403
144MP0003300_gastrointestinal_ulcer0.81939878
145MP0005197_abnormal_uvea_morphology0.81882578
146MP0002272_abnormal_nervous_system0.81591025
147* MP0001614_abnormal_blood_vessel0.81496498
148MP0003119_abnormal_digestive_system0.81280858
149* MP0002080_prenatal_lethality0.81188171
150MP0003795_abnormal_bone_structure0.80056277
151MP0002160_abnormal_reproductive_system0.79797576
152MP0000470_abnormal_stomach_morphology0.79146414
153* MP0000266_abnormal_heart_morphology0.78875322
154MP0002928_abnormal_bile_duct0.78794602
155MP0001119_abnormal_female_reproductive0.78363401
156MP0002557_abnormal_social/conspecific_i0.77886789
157MP0001879_abnormal_lymphatic_vessel0.76668814
158MP0004484_altered_response_of0.76629159
159MP0005220_abnormal_exocrine_pancreas0.75335593
160MP0005670_abnormal_white_adipose0.74831589
161MP0005253_abnormal_eye_physiology0.74499358
162MP0000013_abnormal_adipose_tissue0.74000567
163MP0002736_abnormal_nociception_after0.73818862
164MP0005248_abnormal_Harderian_gland0.72795787
165MP0008877_abnormal_DNA_methylation0.72316399

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.69464798
2Lip pit (HP:0100267)4.79483669
3Depressed nasal tip (HP:0000437)4.70708655
4Anal stenosis (HP:0002025)4.48131310
5Premature rupture of membranes (HP:0001788)4.39525980
6Autoimmune thrombocytopenia (HP:0001973)3.82017780
7Sparse lateral eyebrow (HP:0005338)3.72421612
8Ankle contracture (HP:0006466)3.58394590
9Tubulointerstitial fibrosis (HP:0005576)3.40815746
10Shallow orbits (HP:0000586)3.40175395
11Neonatal short-limb short stature (HP:0008921)3.40069394
12Intestinal fistula (HP:0100819)3.36009470
13Pancreatic cysts (HP:0001737)3.27291939
14Tubular atrophy (HP:0000092)3.21344337
15Epiphyseal dysplasia (HP:0002656)3.20274743
16Abnormality of the renal cortex (HP:0011035)3.17303027
17Preaxial foot polydactyly (HP:0001841)3.07727779
18Cervical subluxation (HP:0003308)3.05791827
19Popliteal pterygium (HP:0009756)3.03143543
20Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.03077155
21Biconcave vertebral bodies (HP:0004586)3.01494364
22Genu recurvatum (HP:0002816)2.93687060
23Congenital sensorineural hearing impairment (HP:0008527)2.93349650
24Medial flaring of the eyebrow (HP:0010747)2.92971643
25Ectopic kidney (HP:0000086)2.91522428
26Polydipsia (HP:0001959)2.90114414
27Abnormal drinking behavior (HP:0030082)2.90114414
28Aortic dissection (HP:0002647)2.88231761
29Mesomelia (HP:0003027)2.86453130
30Flat acetabular roof (HP:0003180)2.76567915
31Cerebral aneurysm (HP:0004944)2.74223085
32Congenital primary aphakia (HP:0007707)2.74151348
33Irregular epiphyses (HP:0010582)2.73726467
34Soft skin (HP:0000977)2.73370832
35Gait imbalance (HP:0002141)2.72273067
36Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71704631
37Short 4th metacarpal (HP:0010044)2.71704631
38Keratoconus (HP:0000563)2.69915939
39Increased corneal curvature (HP:0100692)2.69915939
40Hypoplastic ischia (HP:0003175)2.66458834
41Aortic aneurysm (HP:0004942)2.66435791
42Metaphyseal cupping (HP:0003021)2.66271251
43Pancreatic fibrosis (HP:0100732)2.65723718
44Atrophic scars (HP:0001075)2.61702984
45Cupped ribs (HP:0000887)2.59494945
46Genital tract atresia (HP:0001827)2.58680951
47Wormian bones (HP:0002645)2.58553121
48Bladder diverticulum (HP:0000015)2.58377098
49Nephrogenic diabetes insipidus (HP:0009806)2.57063012
50Abnormality of dentin (HP:0010299)2.55428081
51True hermaphroditism (HP:0010459)2.54382370
52Broad metatarsal (HP:0001783)2.53713024
53Abnormality of the acetabulum (HP:0003170)2.52449485
54Abnormality of the fingertips (HP:0001211)2.51376283
55Vaginal atresia (HP:0000148)2.49910888
56Tubulointerstitial abnormality (HP:0001969)2.48216089
57Preauricular pit (HP:0004467)2.45662013
58Periauricular skin pits (HP:0100277)2.45662013
59Flat capital femoral epiphysis (HP:0003370)2.44495207
60Mitral valve prolapse (HP:0001634)2.43493484
61Aplasia/Hypoplasia of the tibia (HP:0005772)2.38615110
62Broad long bones (HP:0005622)2.37987526
63Dilatation of the ascending aorta (HP:0005111)2.37680574
64Wide intermamillary distance (HP:0006610)2.37624767
65Broad palm (HP:0001169)2.36969245
66Small epiphyses (HP:0010585)2.35500971
67Blue irides (HP:0000635)2.35390477
68Coxa vara (HP:0002812)2.35272607
69Hyperventilation (HP:0002883)2.35197009
70Vertebral compression fractures (HP:0002953)2.34353573
71Blue sclerae (HP:0000592)2.32063355
72Mild short stature (HP:0003502)2.28730267
73Abnormality of the ischium (HP:0003174)2.28341250
74Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.28287028
75Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.28078903
76Abnormality of alanine metabolism (HP:0010916)2.27280603
77Hyperalaninemia (HP:0003348)2.27280603
78Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27280603
79Absent eyebrow (HP:0002223)2.26937216
80Broad thumb (HP:0011304)2.26077263
81Cutaneous finger syndactyly (HP:0010554)2.25321860
82Peritonitis (HP:0002586)2.25139749
83Abnormal vertebral ossification (HP:0100569)2.24903988
84Dislocated radial head (HP:0003083)2.24809579
85Limited elbow extension (HP:0001377)2.24575666
86Broad phalanx (HP:0006009)2.24417592
87Hypoplastic labia majora (HP:0000059)2.22647256
88Abnormal biliary tract physiology (HP:0012439)2.21853000
89Bile duct proliferation (HP:0001408)2.21853000
90Lower limb hyperreflexia (HP:0002395)2.20829018
91Abnormality of the calcaneus (HP:0008364)2.19205767
92Wrist flexion contracture (HP:0001239)2.19143767
93Abnormal foot bone ossification (HP:0010675)2.18659372
94Hip contracture (HP:0003273)2.18114804
95Increased CSF protein (HP:0002922)2.16493528
96Platyspondyly (HP:0000926)2.16472081
97Abnormality of the 4th metacarpal (HP:0010012)2.15885333
98Radial bowing (HP:0002986)2.15456760
99Abnormality of the radial head (HP:0003995)2.15344554
100Broad phalanges of the hand (HP:0009768)2.13967749
101Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.13656641
102Breech presentation (HP:0001623)2.13305195
103Chronic hepatic failure (HP:0100626)2.12549167
104Supernumerary spleens (HP:0009799)2.11200148
105Vitreoretinal degeneration (HP:0000655)2.11101357
106Osteoarthritis (HP:0002758)2.10577339
107Abnormal respiratory epithelium morphology (HP:0012253)2.10065742
108Abnormal respiratory motile cilium morphology (HP:0005938)2.10065742
109Median cleft lip (HP:0000161)2.09622121
110Poor coordination (HP:0002370)2.09397297
111Broad finger (HP:0001500)2.09274547
112Joint laxity (HP:0001388)2.09267223
113Broad hallux (HP:0010055)2.09233873
114Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.09064622
115Abnormal ossification of hand bones (HP:0005921)2.08621264
116Abnormality of the renal medulla (HP:0100957)2.07996543
117Increased connective tissue (HP:0009025)2.05907240
118Ureteral stenosis (HP:0000071)2.05375772
119Short tibia (HP:0005736)2.04161395
120Polyuria (HP:0000103)2.04104412
121Molar tooth sign on MRI (HP:0002419)2.03955992
122Abnormality of midbrain morphology (HP:0002418)2.03955992
123Fragile skin (HP:0001030)2.03422536
124Abnormality of the proximal phalanges of the hand (HP:0009834)2.02649076
125Renal cortical cysts (HP:0000803)2.02355539
126Aplasia/Hypoplasia of the lens (HP:0008063)2.01825630
127Type 1 muscle fiber predominance (HP:0003803)2.01480997
128Bowel diverticulosis (HP:0005222)2.00480202
129Renal duplication (HP:0000075)1.99290185
130Abnormality of the labia majora (HP:0012881)1.98277488
131Abnormality of the distal phalanx of the thumb (HP:0009617)1.97468067
132Spinal cord compression (HP:0002176)1.97303865
133Limited hip movement (HP:0008800)1.97124227
134Proximal tubulopathy (HP:0000114)1.96829704
135Nephronophthisis (HP:0000090)1.96807783
136Thin ribs (HP:0000883)1.96454209
137Exostoses (HP:0100777)1.96064969
138Ulnar bowing (HP:0003031)1.95141370
139Abnormality of carpal bone ossification (HP:0006257)1.93467565
140Lumbar hyperlordosis (HP:0002938)1.92801785
141Ureteral obstruction (HP:0006000)1.92800196
142Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.92277901
143Vertebral hypoplasia (HP:0008417)1.92277901
144Abnormal tarsal ossification (HP:0008369)1.91654410
145Spinal cord lesions (HP:0100561)1.91517679
146Syringomyelia (HP:0003396)1.91517679
147Increased density of long bones (HP:0006392)1.89705284
148Disproportionate tall stature (HP:0001519)1.89577431
149Thoracolumbar scoliosis (HP:0002944)1.88908650
150Persistence of primary teeth (HP:0006335)1.87380468
151Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.87189078
152Abnormality of femoral epiphyses (HP:0006499)1.87189078
153Mucopolysacchariduria (HP:0008155)1.87088502
154Urinary glycosaminoglycan excretion (HP:0003541)1.87088502
155Deviation of the thumb (HP:0009603)1.86465387
156Spinal rigidity (HP:0003306)1.86252419
157Broad toe (HP:0001837)1.86206345
158Short hallux (HP:0010109)1.85232936
159Aplasia/Hypoplasia of the hallux (HP:0008362)1.84371628
160Delayed epiphyseal ossification (HP:0002663)1.83921542
161Hypoglycemic coma (HP:0001325)1.83684763
162Flattened epiphyses (HP:0003071)1.83002974
163Short 5th finger (HP:0009237)1.82807181
164Shawl scrotum (HP:0000049)1.81790937
165Hypophosphatemic rickets (HP:0004912)1.81301502
166Spondylolisthesis (HP:0003302)1.81171992
167Camptodactyly of toe (HP:0001836)1.80863497
168Knee flexion contracture (HP:0006380)1.79902717
169Selective tooth agenesis (HP:0001592)1.78223238
170Absent frontal sinuses (HP:0002688)1.77691629
171Cystic liver disease (HP:0006706)1.76893142
172Rhizomelia (HP:0008905)1.76082330
173Congenital, generalized hypertrichosis (HP:0004540)1.75293261
174Glomerulonephritis (HP:0000099)1.75139662
175Elbow flexion contracture (HP:0002987)1.75121444
176Ectropion (HP:0000656)1.74619559
177Upper limb amyotrophy (HP:0009129)1.74618395
178Distal upper limb amyotrophy (HP:0007149)1.74618395
179Respiratory distress (HP:0002098)1.74536453
180Slender build (HP:0001533)1.74407493
181Potter facies (HP:0002009)1.74184759
182Facial shape deformation (HP:0011334)1.74184759
183Anal atresia (HP:0002023)1.73389662
184Abnormal hand bone ossification (HP:0010660)1.73197967
185Abnormal urine output (HP:0012590)1.71600347
186Posterior subcapsular cataract (HP:0007787)1.69404421
187Abnormality of mucopolysaccharide metabolism (HP:0011020)1.69297337
188Abnormality of polysaccharide metabolism (HP:0011012)1.69297337
189Abnormality of glycosaminoglycan metabolism (HP:0004371)1.69297337
190Ketoacidosis (HP:0001993)1.68815339
191Postaxial hand polydactyly (HP:0001162)1.68269369
192Cutaneous syndactyly (HP:0012725)1.68176052
193Atonic seizures (HP:0010819)1.65113285
194Pheochromocytoma (HP:0002666)1.64120450
195Labial hypoplasia (HP:0000066)1.63406572

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.99599638
2WNK44.10552639
3TRIB33.82400896
4PINK13.71157754
5FRK3.53707744
6EEF2K3.29957906
7CDK123.21252962
8TTN3.12534966
9PKN23.03146132
10CCNB12.97176671
11DDR22.90206465
12CASK2.66412419
13LATS12.39692181
14ZAK2.25298977
15MAP3K22.22890444
16STK102.18860740
17INSRR2.10291132
18MAP3K102.09235080
19BMPR1B2.03843765
20CDC71.97168697
21TNIK1.88746264
22LATS21.86864629
23RIPK11.86395504
24EPHA31.83996088
25LRRK21.79352211
26PDGFRA1.76210809
27ERN11.71872410
28RPS6KA41.65991400
29NTRK21.58773418
30WNK31.56143158
31BRD41.55906103
32MAP4K21.53642727
33SIK11.53248826
34AKT31.52671616
35NEK21.48704239
36PAK21.45080019
37MTOR1.41816101
38RPS6KB21.40746845
39STK31.39151955
40PAK41.38269100
41TGFBR11.37701085
42PNCK1.37629512
43BUB11.33026337
44NME21.30578658
45PTK61.30194520
46WNK11.28513210
47TTK1.23430895
48NEK11.23301085
49EPHB21.22738190
50TAOK11.22452318
51CAMKK21.21667432
52GRK11.21510064
53OXSR11.20208430
54MAP3K31.18582496
55MAPK131.17676566
56CDK71.12162640
57TIE11.11779265
58MAP2K31.08803526
59CAMK11.07180962
60FGFR11.06885361
61OBSCN1.06107092
62MAPKAPK51.05810939
63BRSK21.05667454
64MAP3K81.04804524
65NEK91.04779221
66CSNK1G11.03946231
67NUAK11.02210176
68PTK21.02049299
69CAMK41.01310779
70BMX1.01250962
71MAP3K40.99009507
72CAMK1D0.98860799
73FGFR20.95860584
74TGFBR20.95215475
75DMPK0.95036680
76MAPKAPK30.94102551
77PIM20.93601572
78TRPM70.92309094
79MOS0.90663052
80STK38L0.88564012
81AURKB0.85932933
82ILK0.82418984
83CSNK1G30.81279746
84PLK10.81233349
85PDGFRB0.80369257
86CDK40.78624669
87CDK60.77195246
88EPHA20.76777396
89DAPK20.76493922
90CSNK1G20.76218122
91SGK20.75759438
92NLK0.75400370
93PRKCE0.74523895
94PDK20.73573019
95PRKCQ0.72597681
96ADRBK20.70784016
97ROCK10.69935845
98MELK0.69462469
99ICK0.69045762
100PLK40.66920420
101JAK30.66851209
102CDK80.66462200
103ATR0.65184370
104PASK0.64974522
105CDK90.64937918
106PRKG20.64747842
107CSNK1A1L0.64146399
108SCYL20.63567948
109MAP3K110.63488346
110FLT30.62411724
111DYRK30.61958819
112ERBB30.61868844
113STK240.61831840
114ERBB20.60327116
115ADRBK10.60147531
116CHEK10.59943605
117NTRK30.59785288
118CHUK0.58088765
119MET0.57984981
120BRSK10.56119036
121MUSK0.55562248
122FGFR40.55013369
123STK160.54613989
124STK40.54477971
125WEE10.53462953
126PHKG20.53320323
127PHKG10.53320323
128SGK4940.52382805
129SGK2230.52382805
130CAMK2A0.52057417
131ACVR1B0.51168034
132ROCK20.48917415
133CAMK1G0.48701961
134RPS6KA20.48625205
135TAF10.48423251
136PIM10.47814431
137CDK20.47810818
138TESK10.47205888
139ZAP700.47077825
140MAP2K70.46062282
141FGFR30.45894965
142EIF2AK30.45868440
143MARK10.44962705
144TAOK20.44466008
145PRKCG0.44425672
146RPS6KA60.44360221
147PRKG10.44181011
148TRIM280.44122798
149MAPK10.43214470
150MAPKAPK20.43015840
151CHEK20.42830705
152RPS6KL10.42773780
153RPS6KC10.42773780
154RET0.42504039
155MINK10.42391814
156FER0.41373461
157TESK20.40660815
158ALK0.40512424
159MAP3K50.40050801
160PAK30.40029005
161ATM0.39591225
162PRKACA0.39094091
163MKNK10.38667737
164RPS6KB10.35965420
165PTK2B0.35528050
166PLK20.33748423
167CSNK1A10.32186272
168EIF2AK20.30513386
169YES10.30098303
170EPHA40.27641386
171PRKAA20.26509953
172PRKAA10.25863059
173MKNK20.25623333
174PRKACG0.24097718

Predicted pathways (KEGG)

RankGene SetZ-score
1Arginine biosynthesis_Homo sapiens_hsa002202.99157512
2ECM-receptor interaction_Homo sapiens_hsa045122.87336092
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.45944191
4Phototransduction_Homo sapiens_hsa047442.36923794
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.35016980
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.29102199
7Cell cycle_Homo sapiens_hsa041102.22955273
8Focal adhesion_Homo sapiens_hsa045102.09768510
9Small cell lung cancer_Homo sapiens_hsa052221.96119205
10MicroRNAs in cancer_Homo sapiens_hsa052061.94954169
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.88707628
12Adherens junction_Homo sapiens_hsa045201.85321678
13p53 signaling pathway_Homo sapiens_hsa041151.84107670
14Proteoglycans in cancer_Homo sapiens_hsa052051.82609555
15Caffeine metabolism_Homo sapiens_hsa002321.80373280
16Basal cell carcinoma_Homo sapiens_hsa052171.78288088
17DNA replication_Homo sapiens_hsa030301.78055247
18Chronic myeloid leukemia_Homo sapiens_hsa052201.77871170
19Linoleic acid metabolism_Homo sapiens_hsa005911.77628425
20Propanoate metabolism_Homo sapiens_hsa006401.73989102
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.72707649
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.69002253
23Nitrogen metabolism_Homo sapiens_hsa009101.67507266
24Butanoate metabolism_Homo sapiens_hsa006501.66095382
25RNA transport_Homo sapiens_hsa030131.63781416
26Selenocompound metabolism_Homo sapiens_hsa004501.63712744
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.61059174
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60279449
29Hippo signaling pathway_Homo sapiens_hsa043901.60255202
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.57283505
31Base excision repair_Homo sapiens_hsa034101.56133063
32TGF-beta signaling pathway_Homo sapiens_hsa043501.55831181
33Tryptophan metabolism_Homo sapiens_hsa003801.54996452
34Protein digestion and absorption_Homo sapiens_hsa049741.51338060
35Bladder cancer_Homo sapiens_hsa052191.50344498
36HTLV-I infection_Homo sapiens_hsa051661.49963849
37ABC transporters_Homo sapiens_hsa020101.49299597
38Viral myocarditis_Homo sapiens_hsa054161.46839313
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46619742
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.46287403
41Spliceosome_Homo sapiens_hsa030401.42323089
42Hedgehog signaling pathway_Homo sapiens_hsa043401.42120598
43Notch signaling pathway_Homo sapiens_hsa043301.40809876
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40667850
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.39841514
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38055371
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36272691
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35219481
49Thyroid cancer_Homo sapiens_hsa052161.34056708
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.29668199
51Colorectal cancer_Homo sapiens_hsa052101.29305485
52Complement and coagulation cascades_Homo sapiens_hsa046101.29301445
53Ovarian steroidogenesis_Homo sapiens_hsa049131.29141092
54Circadian entrainment_Homo sapiens_hsa047131.28548198
55Retinol metabolism_Homo sapiens_hsa008301.28331521
56One carbon pool by folate_Homo sapiens_hsa006701.27752571
57Dilated cardiomyopathy_Homo sapiens_hsa054141.27463329
58Protein export_Homo sapiens_hsa030601.26219122
59Taste transduction_Homo sapiens_hsa047421.25026453
60Pancreatic cancer_Homo sapiens_hsa052121.24823864
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24005332
62PI3K-Akt signaling pathway_Homo sapiens_hsa041511.23190166
63Mismatch repair_Homo sapiens_hsa034301.22930945
64Salivary secretion_Homo sapiens_hsa049701.21323529
65Amoebiasis_Homo sapiens_hsa051461.20890349
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20790558
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20208341
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19752773
69Viral carcinogenesis_Homo sapiens_hsa052031.18730713
70Fatty acid elongation_Homo sapiens_hsa000621.15207901
71Drug metabolism - other enzymes_Homo sapiens_hsa009831.13879319
72Lysine degradation_Homo sapiens_hsa003101.13729807
73Apoptosis_Homo sapiens_hsa042101.13065920
74mRNA surveillance pathway_Homo sapiens_hsa030151.12878740
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.12625742
76Pathways in cancer_Homo sapiens_hsa052001.11929046
77Circadian rhythm_Homo sapiens_hsa047101.09528719
78AMPK signaling pathway_Homo sapiens_hsa041521.07833185
79Shigellosis_Homo sapiens_hsa051311.07748102
80Hepatitis B_Homo sapiens_hsa051611.07326742
81RNA degradation_Homo sapiens_hsa030181.06957043
82Prostate cancer_Homo sapiens_hsa052151.06076539
83Nucleotide excision repair_Homo sapiens_hsa034201.04051494
84Ether lipid metabolism_Homo sapiens_hsa005651.04050095
85Chemical carcinogenesis_Homo sapiens_hsa052041.03989358
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03468846
87Toxoplasmosis_Homo sapiens_hsa051451.03400741
88Nicotine addiction_Homo sapiens_hsa050331.00542094
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00307104
90Acute myeloid leukemia_Homo sapiens_hsa052210.99788713
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99351979
92beta-Alanine metabolism_Homo sapiens_hsa004100.98675200
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.98643464
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98226502
95Long-term depression_Homo sapiens_hsa047300.96096284
96Malaria_Homo sapiens_hsa051440.95859221
97Arginine and proline metabolism_Homo sapiens_hsa003300.95844742
98mTOR signaling pathway_Homo sapiens_hsa041500.95723751
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94319664
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94228215
101Regulation of autophagy_Homo sapiens_hsa041400.93990312
102Morphine addiction_Homo sapiens_hsa050320.92772419
103Melanoma_Homo sapiens_hsa052180.91698577
104Epstein-Barr virus infection_Homo sapiens_hsa051690.91662027
105Oxidative phosphorylation_Homo sapiens_hsa001900.91421383
106Histidine metabolism_Homo sapiens_hsa003400.91033207
107Endometrial cancer_Homo sapiens_hsa052130.90605806
108Non-homologous end-joining_Homo sapiens_hsa034500.90531476
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90355374
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.90102215
111Dopaminergic synapse_Homo sapiens_hsa047280.89751058
112Folate biosynthesis_Homo sapiens_hsa007900.89068610
113Cardiac muscle contraction_Homo sapiens_hsa042600.87399521
114Olfactory transduction_Homo sapiens_hsa047400.87287233
115Homologous recombination_Homo sapiens_hsa034400.86823302
116Serotonergic synapse_Homo sapiens_hsa047260.86239305
117Platelet activation_Homo sapiens_hsa046110.86155175
118Peroxisome_Homo sapiens_hsa041460.86051639
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85431402
120HIF-1 signaling pathway_Homo sapiens_hsa040660.84967970
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.83752969
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83703947
123Herpes simplex infection_Homo sapiens_hsa051680.83277628
124Non-small cell lung cancer_Homo sapiens_hsa052230.81800576
125Wnt signaling pathway_Homo sapiens_hsa043100.81434864
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81390955
127Fatty acid degradation_Homo sapiens_hsa000710.78860986
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.78127059
129TNF signaling pathway_Homo sapiens_hsa046680.77903458
130Renin secretion_Homo sapiens_hsa049240.75472096
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75312121
132Arachidonic acid metabolism_Homo sapiens_hsa005900.73503307
133Antigen processing and presentation_Homo sapiens_hsa046120.73336180
134Sulfur metabolism_Homo sapiens_hsa009200.71211167
135Leishmaniasis_Homo sapiens_hsa051400.69380083
136Glioma_Homo sapiens_hsa052140.67299031
137Insulin secretion_Homo sapiens_hsa049110.67117974
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66792878
139Vitamin B6 metabolism_Homo sapiens_hsa007500.66550583
140GABAergic synapse_Homo sapiens_hsa047270.65153221
141FoxO signaling pathway_Homo sapiens_hsa040680.65139857
142Renal cell carcinoma_Homo sapiens_hsa052110.65121745
143Glycerolipid metabolism_Homo sapiens_hsa005610.64568486
144Alzheimers disease_Homo sapiens_hsa050100.64503667
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63555252
146Mineral absorption_Homo sapiens_hsa049780.63512200
147Ribosome_Homo sapiens_hsa030100.62949939
148Fat digestion and absorption_Homo sapiens_hsa049750.61988520
149Cysteine and methionine metabolism_Homo sapiens_hsa002700.61768587
150Basal transcription factors_Homo sapiens_hsa030220.61716814
151Rap1 signaling pathway_Homo sapiens_hsa040150.61541663
152N-Glycan biosynthesis_Homo sapiens_hsa005100.61279447
153Osteoclast differentiation_Homo sapiens_hsa043800.61271236
154Vitamin digestion and absorption_Homo sapiens_hsa049770.61075902
155Bile secretion_Homo sapiens_hsa049760.61028884
156Calcium signaling pathway_Homo sapiens_hsa040200.60540941
157Fatty acid metabolism_Homo sapiens_hsa012120.59763782
158Dorso-ventral axis formation_Homo sapiens_hsa043200.59525348
159Measles_Homo sapiens_hsa051620.58845768
160Collecting duct acid secretion_Homo sapiens_hsa049660.58824983
161PPAR signaling pathway_Homo sapiens_hsa033200.58055527
162NF-kappa B signaling pathway_Homo sapiens_hsa040640.57849288
163Oocyte meiosis_Homo sapiens_hsa041140.57446995
164B cell receptor signaling pathway_Homo sapiens_hsa046620.56779373
165VEGF signaling pathway_Homo sapiens_hsa043700.56561372
166Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56532609
167Tight junction_Homo sapiens_hsa045300.55007925
168Parkinsons disease_Homo sapiens_hsa050120.54796368
169Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54494804
170Sulfur relay system_Homo sapiens_hsa041220.54374598
171Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54033411
172Insulin resistance_Homo sapiens_hsa049310.53501869
173Fanconi anemia pathway_Homo sapiens_hsa034600.53391080
174Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52735043
175Starch and sucrose metabolism_Homo sapiens_hsa005000.52441679
176Metabolic pathways_Homo sapiens_hsa011000.51165069
177Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51009236
178Tyrosine metabolism_Homo sapiens_hsa003500.50605185
179Pyrimidine metabolism_Homo sapiens_hsa002400.50159395
180Jak-STAT signaling pathway_Homo sapiens_hsa046300.50059921
181Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49253657
182Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48991329
183RNA polymerase_Homo sapiens_hsa030200.48652409
184Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48032233

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