DISP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of two human homologs of a segment-polarity gene known as dispatched identified in Drosophila. The product of this gene may be required for normal Hedgehog (Hh) signaling during embryonic pattern formation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.08561253
2synaptic vesicle maturation (GO:0016188)5.84513912
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.80275547
4behavioral response to nicotine (GO:0035095)5.28652509
5locomotory exploration behavior (GO:0035641)5.20463848
6synaptic vesicle exocytosis (GO:0016079)5.14037568
7regulation of synaptic vesicle exocytosis (GO:2000300)5.07713898
8vocalization behavior (GO:0071625)4.79153730
9glutamate secretion (GO:0014047)4.77307790
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.58952022
11neurotransmitter secretion (GO:0007269)4.54194618
12regulation of synaptic vesicle transport (GO:1902803)4.52737176
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.34645485
14neuron cell-cell adhesion (GO:0007158)4.31667685
15regulation of glutamate receptor signaling pathway (GO:1900449)4.28502379
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.25879496
17neuronal action potential propagation (GO:0019227)4.21917551
18exploration behavior (GO:0035640)4.11319972
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.09476900
20neuromuscular process controlling posture (GO:0050884)4.04482230
21proline transport (GO:0015824)4.01865583
22regulation of neuronal synaptic plasticity (GO:0048168)3.95705302
23protein localization to synapse (GO:0035418)3.94336353
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.92833003
25pyrimidine nucleobase catabolic process (GO:0006208)3.91542645
26gamma-aminobutyric acid transport (GO:0015812)3.89364259
27cellular potassium ion homeostasis (GO:0030007)3.88510776
28presynaptic membrane assembly (GO:0097105)3.84630579
29activation of protein kinase A activity (GO:0034199)3.84516225
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.81566589
31neurotransmitter transport (GO:0006836)3.79783723
32cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.75713022
33layer formation in cerebral cortex (GO:0021819)3.69199866
34auditory behavior (GO:0031223)3.66177417
35synaptic transmission, glutamatergic (GO:0035249)3.65664593
36positive regulation of synaptic transmission, GABAergic (GO:0032230)3.64382333
37cerebellar Purkinje cell layer development (GO:0021680)3.62898282
38presynaptic membrane organization (GO:0097090)3.59083022
39sodium ion export (GO:0071436)3.57262118
40glutamate receptor signaling pathway (GO:0007215)3.53938688
41cerebellar Purkinje cell differentiation (GO:0021702)3.50709994
42neuronal action potential (GO:0019228)3.50011868
43neuron-neuron synaptic transmission (GO:0007270)3.49412787
44long-term memory (GO:0007616)3.46587925
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.46113757
46regulation of neurotransmitter levels (GO:0001505)3.45420386
47regulation of synapse structural plasticity (GO:0051823)3.42927488
48cell communication by electrical coupling (GO:0010644)3.42880542
49nucleobase catabolic process (GO:0046113)3.41178873
50glycine transport (GO:0015816)3.40460693
51dendritic spine morphogenesis (GO:0060997)3.39699150
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.37354257
53regulation of vesicle fusion (GO:0031338)3.37128026
54positive regulation of membrane potential (GO:0045838)3.28759885
55serotonin metabolic process (GO:0042428)3.28218121
56G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.28013252
57neuron recognition (GO:0008038)3.27667578
58synaptic vesicle endocytosis (GO:0048488)3.27006808
59vesicle transport along microtubule (GO:0047496)3.25579372
60fucose catabolic process (GO:0019317)3.25437445
61L-fucose metabolic process (GO:0042354)3.25437445
62L-fucose catabolic process (GO:0042355)3.25437445
63innervation (GO:0060384)3.24778788
64regulation of calcium ion-dependent exocytosis (GO:0017158)3.23965152
65positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.23006647
66positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.21206510
67gamma-aminobutyric acid signaling pathway (GO:0007214)3.17607611
68regulation of neurotransmitter secretion (GO:0046928)3.17466261
69primary amino compound metabolic process (GO:1901160)3.17344362
70transmission of nerve impulse (GO:0019226)3.17088639
71membrane depolarization during action potential (GO:0086010)3.16649162
72negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.14958029
73detection of calcium ion (GO:0005513)3.14698679
74regulation of excitatory postsynaptic membrane potential (GO:0060079)3.13855727
75behavioral response to ethanol (GO:0048149)3.12564014
76chemosensory behavior (GO:0007635)3.10975503
77mechanosensory behavior (GO:0007638)3.10369221
78neurotransmitter-gated ion channel clustering (GO:0072578)3.08791590
79regulation of postsynaptic membrane potential (GO:0060078)3.08747602
80insulin secretion (GO:0030073)3.08366866
81regulation of synaptic plasticity (GO:0048167)3.05182418
82response to pheromone (GO:0019236)3.02082124
83regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.01702788
84neuromuscular synaptic transmission (GO:0007274)2.99731995
85neuromuscular process controlling balance (GO:0050885)2.97319329
86mating behavior (GO:0007617)2.97287047
87negative regulation of synaptic transmission, GABAergic (GO:0032229)2.96560899
88signal release (GO:0023061)2.96347606
89regulation of ARF protein signal transduction (GO:0032012)2.96265814
90positive regulation of potassium ion transmembrane transport (GO:1901381)2.96238613
91long-term synaptic potentiation (GO:0060291)2.94441469
92regulation of neurotransmitter transport (GO:0051588)2.94095852
93potassium ion import (GO:0010107)2.93908952
94potassium ion homeostasis (GO:0055075)2.93767963
95postsynaptic membrane organization (GO:0001941)2.93690889
96axon ensheathment in central nervous system (GO:0032291)2.93170138
97central nervous system myelination (GO:0022010)2.93170138
98axonal fasciculation (GO:0007413)2.93118926
99startle response (GO:0001964)2.91651629
100suckling behavior (GO:0001967)2.91080826
101regulation of exocytosis (GO:0017157)2.89931094
102regulation of respiratory system process (GO:0044065)2.89784544
103detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.89702162
104organelle transport along microtubule (GO:0072384)2.88865311
105axon cargo transport (GO:0008088)2.87767723
106dendrite morphogenesis (GO:0048813)2.87703691
107cell migration in hindbrain (GO:0021535)2.87430261
108regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.87394191
109positive regulation of exocytosis (GO:0045921)2.86709902
110neuronal ion channel clustering (GO:0045161)2.86698724
111regulation of synaptic transmission, glutamatergic (GO:0051966)2.86570239
112positive regulation of synapse maturation (GO:0090129)2.86357891
113social behavior (GO:0035176)2.86250392
114intraspecies interaction between organisms (GO:0051703)2.86250392
115positive regulation of sodium ion transmembrane transport (GO:1902307)2.86123093
116membrane hyperpolarization (GO:0060081)2.85044724
117response to auditory stimulus (GO:0010996)2.84025453
118synapse assembly (GO:0007416)2.84009215
119regulation of neurotransmitter uptake (GO:0051580)2.83733965
120negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83308962
121regulation of action potential (GO:0098900)2.83244637
122positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.82376794
123synaptic transmission (GO:0007268)2.82356344
124regulation of synaptic transmission, GABAergic (GO:0032228)2.82109309
125membrane depolarization (GO:0051899)2.81613931
126synaptic vesicle transport (GO:0048489)2.80142650
127establishment of synaptic vesicle localization (GO:0097480)2.80142650
128urinary tract smooth muscle contraction (GO:0014848)2.78972971
129positive regulation of synapse assembly (GO:0051965)2.77299827
130action potential (GO:0001508)2.76288575
131C4-dicarboxylate transport (GO:0015740)2.75135291
132epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71587293
133atrial cardiac muscle cell action potential (GO:0086014)2.70855413
134cAMP catabolic process (GO:0006198)2.66771312
135adult walking behavior (GO:0007628)2.66241429
136adult behavior (GO:0030534)2.65101135
137synaptic transmission, cholinergic (GO:0007271)2.61540167
138protein polyglutamylation (GO:0018095)2.61375261
139detection of light stimulus involved in visual perception (GO:0050908)2.60423337
140detection of light stimulus involved in sensory perception (GO:0050962)2.60423337
141negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.60359205
142regulation of synapse maturation (GO:0090128)2.59506840
143positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.58751575
144protein localization to cilium (GO:0061512)2.57568841
145positive regulation of dendritic spine development (GO:0060999)2.56452175
146indole-containing compound metabolic process (GO:0042430)2.56317859
147behavioral defense response (GO:0002209)2.54599792
148behavioral fear response (GO:0001662)2.54599792
149potassium ion transmembrane transport (GO:0071805)2.52888415
150cellular potassium ion transport (GO:0071804)2.52888415
151indolalkylamine metabolic process (GO:0006586)2.50793132

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.04347238
2GBX2_23144817_ChIP-Seq_PC3_Human3.35619111
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01657244
4* REST_21632747_ChIP-Seq_MESCs_Mouse2.97489308
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93151947
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.81241250
7* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57279062
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54791407
9DROSHA_22980978_ChIP-Seq_HELA_Human2.52502167
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50140029
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50140029
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48367014
13* REST_18959480_ChIP-ChIP_MESCs_Mouse2.45761181
14VDR_22108803_ChIP-Seq_LS180_Human2.44463527
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44346875
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.44328617
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41958611
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.41690367
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37311616
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.34600559
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.21267201
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20602719
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.19637219
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.13460846
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.03549956
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99575749
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99023020
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88823146
29* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79411076
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76333360
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76148978
32ZNF274_21170338_ChIP-Seq_K562_Hela1.70470615
33SMAD4_21799915_ChIP-Seq_A2780_Human1.69758270
34FUS_26573619_Chip-Seq_HEK293_Human1.60933479
35* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.54432882
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51083085
37IGF1R_20145208_ChIP-Seq_DFB_Human1.49915531
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.47801885
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47344795
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46084321
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46084321
42TAF15_26573619_Chip-Seq_HEK293_Human1.44834448
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.44253744
44ER_23166858_ChIP-Seq_MCF-7_Human1.42078903
45EWS_26573619_Chip-Seq_HEK293_Human1.41746491
46AR_21572438_ChIP-Seq_LNCaP_Human1.41606709
47* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38730743
48SOX2_21211035_ChIP-Seq_LN229_Gbm1.36661465
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36040642
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35709333
51STAT3_23295773_ChIP-Seq_U87_Human1.31501323
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29013808
53AR_19668381_ChIP-Seq_PC3_Human1.26377418
54P300_19829295_ChIP-Seq_ESCs_Human1.25563431
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25518515
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24390062
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22541783
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.22475433
59AR_25329375_ChIP-Seq_VCAP_Human1.21553894
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21366642
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20298139
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20078524
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17751128
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17540406
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16663468
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.16461254
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.14674891
68CBP_20019798_ChIP-Seq_JUKART_Human1.13113055
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13113055
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12709455
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12292904
72* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11547587
73TP53_22573176_ChIP-Seq_HFKS_Human1.10789167
74YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09807883
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09073603
76TCF4_23295773_ChIP-Seq_U87_Human1.09042777
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08883088
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08716562
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08599249
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.08232691
81TCF4_22108803_ChIP-Seq_LS180_Human1.05999349
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05621044
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05415854
84* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03970673
85KDM2B_26808549_Chip-Seq_K562_Human1.03480580
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.03148082
87SMAD3_21741376_ChIP-Seq_ESCs_Human1.03065426
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.02996681
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02711682
90ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01506192
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01474270
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01045439
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01029785
94CBX2_27304074_Chip-Seq_ESCs_Mouse1.00571467
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00421585
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99739132
97ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99227542
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98716506
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98329136
100NANOG_18555785_Chip-Seq_ESCs_Mouse0.98153722
101PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98040980
102RNF2_27304074_Chip-Seq_NSC_Mouse0.98034207
103ARNT_22903824_ChIP-Seq_MCF-7_Human0.97433225
104SALL1_21062744_ChIP-ChIP_HESCs_Human0.97111487
105SOX2_19829295_ChIP-Seq_ESCs_Human0.96322142
106NANOG_19829295_ChIP-Seq_ESCs_Human0.96322142
107RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96110066
108AHR_22903824_ChIP-Seq_MCF-7_Human0.95854862
109RING1B_27294783_Chip-Seq_NPCs_Mouse0.95397256
110RUNX2_22187159_ChIP-Seq_PCA_Human0.95316093
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95233473
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.94165581
113KDM2B_26808549_Chip-Seq_REH_Human0.93407581
114SMAD_19615063_ChIP-ChIP_OVARY_Human0.92789336
115POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92300821
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91743109
117FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91035508
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91028343
119OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90395503
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88131511
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87790204
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87582423
123WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86577007
124* TET1_21490601_ChIP-Seq_MESCs_Mouse0.86426027
125P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86310265
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85615010
127BCAT_22108803_ChIP-Seq_LS180_Human0.84459498
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83078241
129CTCF_27219007_Chip-Seq_Bcells_Human0.82281062
130MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81750258

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.43073832
2MP0003880_abnormal_central_pattern4.22022444
3MP0003635_abnormal_synaptic_transmissio3.77562314
4MP0004270_analgesia3.46923421
5MP0009745_abnormal_behavioral_response3.02620422
6MP0002064_seizures2.91763687
7MP0002063_abnormal_learning/memory/cond2.88480735
8MP0009046_muscle_twitch2.86474701
9MP0002909_abnormal_adrenal_gland2.83776083
10MP0005423_abnormal_somatic_nervous2.73971576
11MP0001968_abnormal_touch/_nociception2.68288337
12MP0009780_abnormal_chondrocyte_physiolo2.66772563
13MP0002734_abnormal_mechanical_nocicepti2.57138045
14MP0002572_abnormal_emotion/affect_behav2.57039742
15MP0002272_abnormal_nervous_system2.47083781
16MP0003122_maternal_imprinting2.41192844
17MP0001501_abnormal_sleep_pattern2.36475456
18MP0005645_abnormal_hypothalamus_physiol2.25813295
19MP0003283_abnormal_digestive_organ2.25279626
20MP0002733_abnormal_thermal_nociception2.16734881
21MP0001486_abnormal_startle_reflex2.11123243
22MP0006276_abnormal_autonomic_nervous2.10694755
23MP0002735_abnormal_chemical_nociception2.07658686
24MP0005646_abnormal_pituitary_gland2.02746972
25MP0008877_abnormal_DNA_methylation1.99902030
26MP0001970_abnormal_pain_threshold1.98084196
27MP0001440_abnormal_grooming_behavior1.92180505
28MP0002736_abnormal_nociception_after1.88813205
29MP0003787_abnormal_imprinting1.87579965
30MP0000013_abnormal_adipose_tissue1.86144540
31MP0004858_abnormal_nervous_system1.85059981
32MP0002067_abnormal_sensory_capabilities1.84178387
33MP0002822_catalepsy1.83412359
34MP0004147_increased_porphyrin_level1.77362507
35MP0002184_abnormal_innervation1.74749228
36MP0010386_abnormal_urinary_bladder1.74631974
37MP0008569_lethality_at_weaning1.73483707
38MP0003329_amyloid_beta_deposits1.71455734
39MP0004742_abnormal_vestibular_system1.69832400
40MP0002557_abnormal_social/conspecific_i1.68047221
41MP0003646_muscle_fatigue1.66806572
42MP0004811_abnormal_neuron_physiology1.64245000
43MP0004043_abnormal_pH_regulation1.58630992
44MP0004924_abnormal_behavior1.56877886
45MP0005386_behavior/neurological_phenoty1.56877886
46MP0000955_abnormal_spinal_cord1.56273806
47MP0003879_abnormal_hair_cell1.47893929
48MP0004133_heterotaxia1.45974747
49MP0001502_abnormal_circadian_rhythm1.43643214
50MP0000778_abnormal_nervous_system1.36210632
51MP0002837_dystrophic_cardiac_calcinosis1.35098806
52MP0001984_abnormal_olfaction1.34792845
53MP0002102_abnormal_ear_morphology1.33923366
54MP0002066_abnormal_motor_capabilities/c1.32802851
55MP0002882_abnormal_neuron_morphology1.30757037
56MP0008961_abnormal_basal_metabolism1.30711093
57MP0003195_calcinosis1.29001970
58MP0003633_abnormal_nervous_system1.28997306
59MP0001485_abnormal_pinna_reflex1.26915484
60MP0004885_abnormal_endolymph1.26306566
61MP0006292_abnormal_olfactory_placode1.24599951
62MP0004142_abnormal_muscle_tone1.22330177
63MP0002638_abnormal_pupillary_reflex1.21435984
64MP0004145_abnormal_muscle_electrophysio1.18928552
65MP0005167_abnormal_blood-brain_barrier1.18890111
66MP0002693_abnormal_pancreas_physiology1.17367056
67MP0005253_abnormal_eye_physiology1.13915088
68MP0003183_abnormal_peptide_metabolism1.13912052
69MP0005379_endocrine/exocrine_gland_phen1.13830380
70MP0001529_abnormal_vocalization1.13413821
71MP0001905_abnormal_dopamine_level1.10185324
72MP0005535_abnormal_body_temperature1.09518136
73MP0003172_abnormal_lysosome_physiology1.07145804
74MP0001944_abnormal_pancreas_morphology1.06813065
75MP0002653_abnormal_ependyma_morphology1.06364263
76MP0008875_abnormal_xenobiotic_pharmacok1.06167604
77MP0002229_neurodegeneration1.06131513
78MP0006072_abnormal_retinal_apoptosis1.05033583
79MP0003136_yellow_coat_color1.04520256
80MP0003631_nervous_system_phenotype1.01057470
81MP0002069_abnormal_eating/drinking_beha0.99648890
82MP0000427_abnormal_hair_cycle0.97363727
83MP0003123_paternal_imprinting0.95519020
84MP0002152_abnormal_brain_morphology0.92830970
85MP0000631_abnormal_neuroendocrine_gland0.92788506
86MP0005174_abnormal_tail_pigmentation0.90793263
87MP0003634_abnormal_glial_cell0.89107699
88MP0002928_abnormal_bile_duct0.88482234
89MP0005551_abnormal_eye_electrophysiolog0.87747843
90MP0001188_hyperpigmentation0.87241645
91MP0003011_delayed_dark_adaptation0.86776498
92MP0002938_white_spotting0.85001978
93MP0002078_abnormal_glucose_homeostasis0.84985557
94MP0002877_abnormal_melanocyte_morpholog0.84699579
95MP0003137_abnormal_impulse_conducting0.84531339
96MP0000026_abnormal_inner_ear0.84390438
97MP0004085_abnormal_heartbeat0.83472575
98MP0005195_abnormal_posterior_eye0.82540349
99MP0002163_abnormal_gland_morphology0.82265290
100MP0003121_genomic_imprinting0.81244640
101MP0001299_abnormal_eye_distance/0.79295782
102MP0008872_abnormal_physiological_respon0.76727537
103MP0000569_abnormal_digit_pigmentation0.76367620
104MP0000751_myopathy0.75932550
105MP0001986_abnormal_taste_sensitivity0.75421370
106MP0002876_abnormal_thyroid_physiology0.74835927
107MP0000003_abnormal_adipose_tissue0.73287504
108MP0002160_abnormal_reproductive_system0.72173651
109MP0003119_abnormal_digestive_system0.72161758
110MP0003953_abnormal_hormone_level0.71785864
111MP0003690_abnormal_glial_cell0.70763913
112MP0003632_abnormal_nervous_system0.69313788
113MP0005499_abnormal_olfactory_system0.68271585
114MP0005394_taste/olfaction_phenotype0.68271585
115MP0001664_abnormal_digestion0.68071848
116MP0002751_abnormal_autonomic_nervous0.67389838
117MP0001177_atelectasis0.66958496
118MP0002234_abnormal_pharynx_morphology0.66567062
119MP0004130_abnormal_muscle_cell0.66539963
120MP0000604_amyloidosis0.65331194
121MP0000566_synostosis0.65294805
122MP0000230_abnormal_systemic_arterial0.64711386
123MP0001963_abnormal_hearing_physiology0.64610807
124MP0008874_decreased_physiological_sensi0.64231317
125MP0001765_abnormal_ion_homeostasis0.63642607
126MP0002090_abnormal_vision0.63034172
127MP0004233_abnormal_muscle_weight0.62517936
128MP0000678_abnormal_parathyroid_gland0.62189928
129MP0002752_abnormal_somatic_nervous0.61458571

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.39872923
2Visual hallucinations (HP:0002367)5.60083239
3Myokymia (HP:0002411)5.22735366
4Focal seizures (HP:0007359)4.98010211
5Atonic seizures (HP:0010819)4.37531873
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.32236382
7Absence seizures (HP:0002121)4.07543794
8Progressive cerebellar ataxia (HP:0002073)4.04528868
9Epileptic encephalopathy (HP:0200134)4.02387546
10Supranuclear gaze palsy (HP:0000605)3.88791354
11Febrile seizures (HP:0002373)3.81113112
12Molar tooth sign on MRI (HP:0002419)3.73981292
13Abnormality of midbrain morphology (HP:0002418)3.73981292
14Generalized tonic-clonic seizures (HP:0002069)3.71972712
15Action tremor (HP:0002345)3.69482067
16Dialeptic seizures (HP:0011146)3.64188999
17Papilledema (HP:0001085)3.61903709
18Pancreatic cysts (HP:0001737)3.55705329
19Agitation (HP:0000713)3.51452332
20Depression (HP:0000716)3.41860484
21Pancreatic fibrosis (HP:0100732)3.41322977
22Pheochromocytoma (HP:0002666)3.40067464
23Congenital stationary night blindness (HP:0007642)3.38617759
24Ankle clonus (HP:0011448)3.28191243
25Nephronophthisis (HP:0000090)3.23985030
26Anxiety (HP:0000739)3.15265450
27True hermaphroditism (HP:0010459)3.13470634
28Truncal ataxia (HP:0002078)3.07231085
29Neuroendocrine neoplasm (HP:0100634)2.92485747
30Inability to walk (HP:0002540)2.88643258
31Postural instability (HP:0002172)2.87600044
32Abnormality of calcium-phosphate metabolism (HP:0100530)2.87406268
33Lissencephaly (HP:0001339)2.86833468
34Epileptiform EEG discharges (HP:0011182)2.86382106
35Abnormality of the renal medulla (HP:0100957)2.83605321
36EEG with generalized epileptiform discharges (HP:0011198)2.83370803
37Abnormal eating behavior (HP:0100738)2.80866717
38Failure to thrive in infancy (HP:0001531)2.74423494
39Hypsarrhythmia (HP:0002521)2.71676349
40Protruding tongue (HP:0010808)2.68455271
41Impaired vibration sensation in the lower limbs (HP:0002166)2.68128717
42Urinary bladder sphincter dysfunction (HP:0002839)2.66165474
43Poor eye contact (HP:0000817)2.66031020
44Impaired smooth pursuit (HP:0007772)2.63842471
45Ventricular fibrillation (HP:0001663)2.62965001
46Dysdiadochokinesis (HP:0002075)2.62880732
47Mutism (HP:0002300)2.62256580
48Genetic anticipation (HP:0003743)2.59705291
49Dysmetria (HP:0001310)2.59294905
50Medial flaring of the eyebrow (HP:0010747)2.58579055
51Gaze-evoked nystagmus (HP:0000640)2.56341432
52Hyperinsulinemic hypoglycemia (HP:0000825)2.54760067
53Gait imbalance (HP:0002141)2.54542440
54Neurofibrillary tangles (HP:0002185)2.53403967
55Retinal dysplasia (HP:0007973)2.52536109
56Impaired social interactions (HP:0000735)2.51794539
57Abnormal social behavior (HP:0012433)2.51794539
58Hemiparesis (HP:0001269)2.51767127
59Menstrual irregularities (HP:0000858)2.51438617
60Broad-based gait (HP:0002136)2.49531609
61Cerebral inclusion bodies (HP:0100314)2.45705369
62Limb dystonia (HP:0002451)2.44988455
63Abnormality of the renal cortex (HP:0011035)2.44843143
64Hypercortisolism (HP:0001578)2.44399510
65Amblyopia (HP:0000646)2.43080188
66Bradykinesia (HP:0002067)2.42750245
67Excessive salivation (HP:0003781)2.41859745
68Drooling (HP:0002307)2.41859745
69Cystic liver disease (HP:0006706)2.41833811
70Chronic hepatic failure (HP:0100626)2.39205698
71Hypoglycemic seizures (HP:0002173)2.38455962
72Pachygyria (HP:0001302)2.36402612
73Birth length less than 3rd percentile (HP:0003561)2.36316734
74Spastic gait (HP:0002064)2.35241187
75Progressive inability to walk (HP:0002505)2.34444066
76Hemiplegia (HP:0002301)2.31773283
77Abolished electroretinogram (ERG) (HP:0000550)2.31764589
78Diplopia (HP:0000651)2.27274460
79Abnormality of binocular vision (HP:0011514)2.27274460
80Abnormal drinking behavior (HP:0030082)2.26720762
81Polydipsia (HP:0001959)2.26720762
82Attenuation of retinal blood vessels (HP:0007843)2.24873071
83Abnormality of ocular smooth pursuit (HP:0000617)2.24866006
84Pendular nystagmus (HP:0012043)2.23671370
85Decreased circulating renin level (HP:0003351)2.21474617
86Hyperventilation (HP:0002883)2.17360147
87Postural tremor (HP:0002174)2.16988818
88Abnormality of alanine metabolism (HP:0010916)2.16938664
89Hyperalaninemia (HP:0003348)2.16938664
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16938664
91Intention tremor (HP:0002080)2.16534887
92Abnormality of the lower motor neuron (HP:0002366)2.16189701
93Psychosis (HP:0000709)2.13846286
94Tubular atrophy (HP:0000092)2.12896412
95Torticollis (HP:0000473)2.12593762
96Polyphagia (HP:0002591)2.11793456
97Insomnia (HP:0100785)2.11069551
98Symptomatic seizures (HP:0011145)2.09777383
99Urinary urgency (HP:0000012)2.08342906
100Scanning speech (HP:0002168)2.08310491
101Patellar aplasia (HP:0006443)2.07366296
102Chorioretinal atrophy (HP:0000533)2.05793345
103Hypothermia (HP:0002045)2.05601439
104Large for gestational age (HP:0001520)2.04921425
105Cerebellar dysplasia (HP:0007033)2.04523112
106Hypoventilation (HP:0002791)2.02406790
107Congenital primary aphakia (HP:0007707)2.01524392
108Aplasia/Hypoplasia of the patella (HP:0006498)2.00123285
109Increased circulating renin level (HP:0000848)1.99511592
110Lower limb muscle weakness (HP:0007340)1.98874972
111Sclerocornea (HP:0000647)1.98137976
112Neuronal loss in central nervous system (HP:0002529)1.96513177
113Focal dystonia (HP:0004373)1.96215299
114Severe muscular hypotonia (HP:0006829)1.95901123
115Clonus (HP:0002169)1.95822305
116Concave nail (HP:0001598)1.95793487
117Restlessness (HP:0000711)1.94595134
118Neoplasm of the heart (HP:0100544)1.94455814
119Macroorchidism (HP:0000053)1.92539271
120Decreased central vision (HP:0007663)1.92394078
121Status epilepticus (HP:0002133)1.92268470
122Megalencephaly (HP:0001355)1.92203608
123Insidious onset (HP:0003587)1.91953402
124Termporal pattern (HP:0011008)1.91953402
125Clumsiness (HP:0002312)1.91729923
126Keratoconus (HP:0000563)1.91217574
127Increased corneal curvature (HP:0100692)1.91217574
128Nephrogenic diabetes insipidus (HP:0009806)1.91155109
129Genital tract atresia (HP:0001827)1.90677898
130Optic nerve hypoplasia (HP:0000609)1.90271277
131Blue irides (HP:0000635)1.88945782
132Neoplasm of the peripheral nervous system (HP:0100007)1.88499832
133Abnormal EKG (HP:0003115)1.87876150
134Gait ataxia (HP:0002066)1.87225670
135Abnormality of the corticospinal tract (HP:0002492)1.86403941
136Absent speech (HP:0001344)1.86350153
137Morphological abnormality of the pyramidal tract (HP:0002062)1.85822112
138Aplasia/Hypoplasia of the tibia (HP:0005772)1.85583691
139Hyperparathyroidism (HP:0000843)1.85087138
140Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84919192
141Rigidity (HP:0002063)1.83002341
142Generalized myoclonic seizures (HP:0002123)1.79923637
143Adrenal overactivity (HP:0002717)1.78072567
144Polyuria (HP:0000103)1.77168708
145Retinal atrophy (HP:0001105)1.76700794
146Widely spaced teeth (HP:0000687)1.76654519
147Abnormality of the pons (HP:0007361)1.76565451
148Craniofacial dystonia (HP:0012179)1.75974656
149Abnormality of the labia minora (HP:0012880)1.75218693
150Type II lissencephaly (HP:0007260)1.74730469
151Furrowed tongue (HP:0000221)1.74107840
152Bundle branch block (HP:0011710)1.73989799
153Specific learning disability (HP:0001328)1.73765817
154Hypoplasia of the pons (HP:0012110)1.73758124
155Rapidly progressive (HP:0003678)1.73118186
156Vaginal atresia (HP:0000148)1.72894349
157Anterior segment dysgenesis (HP:0007700)1.72320744
158Dyskinesia (HP:0100660)1.70337265
159Anencephaly (HP:0002323)1.69270269
160Akinesia (HP:0002304)1.69209673
161Abnormal rod and cone electroretinograms (HP:0008323)1.66821262
162Intellectual disability, severe (HP:0010864)1.65404297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.09821497
2MAP3K93.75374819
3MAP3K43.09741070
4MARK12.79967407
5MINK12.65102240
6BMPR1B2.61032175
7EPHA42.59432864
8NTRK12.58481411
9ADRBK22.51068090
10MAP2K72.45084430
11PRKD32.41556249
12MAP3K122.17766249
13PAK62.12083499
14ACVR1B2.10547792
15NTRK22.09395879
16MAP2K41.98447003
17KSR21.85272818
18MAP4K21.76958497
19CAMKK11.74495570
20UHMK11.73225427
21INSRR1.72378123
22DAPK21.71810070
23PNCK1.69281108
24MAP3K21.66582927
25GRK11.61948019
26GRK51.61653301
27CDK51.50458060
28CAMKK21.44026144
29ZAK1.35984345
30STK381.35815615
31RIPK41.33069035
32DYRK21.32471307
33CASK1.31020332
34TLK11.27647261
35ARAF1.26830605
36STK391.26168312
37PRKCG1.23200748
38PRKCH1.20629593
39TNIK1.17813048
40MAPK131.17470774
41MAP3K11.17170075
42WNK31.16935795
43SCYL21.14144869
44PLK21.11844445
45DAPK11.09096552
46PAK31.08503117
47RET1.06078501
48KSR11.05479946
49FES1.04497827
50CDC42BPA1.01152664
51FGFR21.00743929
52SGK2230.99745711
53SGK4940.99745711
54CAMK2A0.99480692
55HIPK20.96469707
56PHKG20.96398589
57PHKG10.96398589
58CDK190.91929570
59CAMK1D0.91309386
60WNK10.90076033
61MKNK20.89024489
62SIK20.88574560
63TAF10.87538628
64MAPK150.87208593
65CAMK10.87078635
66ALK0.86975595
67SGK20.85709078
68CAMK2B0.82823753
69NUAK10.80769101
70PKN10.80263459
71CAMK1G0.79162696
72MAPKAPK50.78699812
73STK110.78084837
74SGK30.76722175
75FER0.75453561
76LMTK20.74283452
77CDK140.74248055
78MAP3K130.73447361
79LATS20.73401367
80CDK180.73140796
81WNK40.72745913
82CSNK1G20.72635249
83CDK150.72314966
84TGFBR10.71929216
85TYRO30.71000309
86PRPF4B0.69334174
87PINK10.68956035
88AKT30.67904729
89CSNK1G30.67367337
90PASK0.66284484
91CAMK2D0.65967633
92MAP2K60.65903793
93DYRK1A0.64841779
94TNK20.64460322
95MARK20.64222686
96CAMK40.63192262
97SGK10.63141705
98TAOK10.62752067
99PRKCE0.62462856
100CDK11A0.60944269
101CSNK1G10.58846513
102CSNK1A1L0.56878953
103RPS6KA30.54158126
104TAOK30.53306321
105RPS6KA20.52961879
106PDGFRA0.52587460
107MAPK100.52430482
108BRSK10.52152250
109CAMK2G0.50772373
110PRKACA0.48272761
111PDK10.48198170
112PDPK10.47292654
113BMPR20.47151038
114PTK2B0.45730482
115BCR0.43971136
116CSNK1A10.43510394
117NEK60.42663392
118RIPK10.42545096
119TXK0.42313670
120PRKG10.42008835
121PTK20.41555604
122PRKAA10.41264671
123BRAF0.40984458
124TIE10.40532273
125OXSR10.39755437
126PRKCZ0.39506174
127PRKCA0.37584114
128MAPK120.37352197
129FYN0.37273384
130PIK3CA0.37226082
131PRKCI0.37030872
132PRKCQ0.36331014
133PRKCB0.35672283
134ADRBK10.35578900
135FRK0.35516098
136TRIM280.34166740
137MAPKAPK30.32358101
138CSNK1D0.32139250
139NME10.31732463
140ERBB20.31638477
141CSNK1E0.31547225
142RPS6KA50.30773740
143LIMK10.27630021

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.45049102
2Synaptic vesicle cycle_Homo sapiens_hsa047213.42777962
3Insulin secretion_Homo sapiens_hsa049112.76955606
4GABAergic synapse_Homo sapiens_hsa047272.76248976
5Circadian entrainment_Homo sapiens_hsa047132.51863938
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.50562050
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.46186769
8Amphetamine addiction_Homo sapiens_hsa050312.42642299
9Long-term potentiation_Homo sapiens_hsa047202.41268617
10Morphine addiction_Homo sapiens_hsa050322.29123429
11Glutamatergic synapse_Homo sapiens_hsa047242.26849663
12Olfactory transduction_Homo sapiens_hsa047402.21665252
13Dopaminergic synapse_Homo sapiens_hsa047282.10982828
14Taste transduction_Homo sapiens_hsa047422.00935815
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.95577724
16Salivary secretion_Homo sapiens_hsa049701.94697892
17Cocaine addiction_Homo sapiens_hsa050301.93663188
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.87604778
19Linoleic acid metabolism_Homo sapiens_hsa005911.83736358
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81681402
21Cholinergic synapse_Homo sapiens_hsa047251.81022254
22Type II diabetes mellitus_Homo sapiens_hsa049301.79552277
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76212425
24Gastric acid secretion_Homo sapiens_hsa049711.72313311
25Serotonergic synapse_Homo sapiens_hsa047261.71689531
26Collecting duct acid secretion_Homo sapiens_hsa049661.66454024
27Renin secretion_Homo sapiens_hsa049241.54954621
28Long-term depression_Homo sapiens_hsa047301.53998859
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53418708
30Vibrio cholerae infection_Homo sapiens_hsa051101.50410006
31Oxidative phosphorylation_Homo sapiens_hsa001901.46340043
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42412543
33Ether lipid metabolism_Homo sapiens_hsa005651.36035322
34Calcium signaling pathway_Homo sapiens_hsa040201.34952263
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34270932
36Type I diabetes mellitus_Homo sapiens_hsa049401.33965210
37Oxytocin signaling pathway_Homo sapiens_hsa049211.32646583
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32276438
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28079317
40GnRH signaling pathway_Homo sapiens_hsa049121.27620745
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26057479
42ABC transporters_Homo sapiens_hsa020101.23687522
43Tryptophan metabolism_Homo sapiens_hsa003801.21344488
44Estrogen signaling pathway_Homo sapiens_hsa049151.21034087
45Gap junction_Homo sapiens_hsa045401.19354809
46cAMP signaling pathway_Homo sapiens_hsa040241.17892463
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15361145
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12319081
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10883255
50Pancreatic secretion_Homo sapiens_hsa049721.09622686
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08863054
52Parkinsons disease_Homo sapiens_hsa050121.07886931
53Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07681256
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01655055
55Thyroid hormone synthesis_Homo sapiens_hsa049181.00939775
56Caffeine metabolism_Homo sapiens_hsa002320.96657615
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96162829
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93536992
59Melanogenesis_Homo sapiens_hsa049160.92791474
60Selenocompound metabolism_Homo sapiens_hsa004500.92589631
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91505219
62Glioma_Homo sapiens_hsa052140.88668174
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.88627719
64Dorso-ventral axis formation_Homo sapiens_hsa043200.88620855
65Cardiac muscle contraction_Homo sapiens_hsa042600.88361337
66Histidine metabolism_Homo sapiens_hsa003400.84952755
67Nitrogen metabolism_Homo sapiens_hsa009100.81766626
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80665880
69Basal transcription factors_Homo sapiens_hsa030220.80277367
70ErbB signaling pathway_Homo sapiens_hsa040120.79178117
71Glucagon signaling pathway_Homo sapiens_hsa049220.77191675
72Axon guidance_Homo sapiens_hsa043600.73118085
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72123287
74Oocyte meiosis_Homo sapiens_hsa041140.67835522
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67412870
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.66847962
77Huntingtons disease_Homo sapiens_hsa050160.64016099
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63361344
79Dilated cardiomyopathy_Homo sapiens_hsa054140.61155356
80Circadian rhythm_Homo sapiens_hsa047100.60713955
81Prion diseases_Homo sapiens_hsa050200.59852134
82Phototransduction_Homo sapiens_hsa047440.59094125
83MAPK signaling pathway_Homo sapiens_hsa040100.58867048
84Mineral absorption_Homo sapiens_hsa049780.58441096
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.58203148
86Glycerolipid metabolism_Homo sapiens_hsa005610.57921855
87Regulation of autophagy_Homo sapiens_hsa041400.57224739
88beta-Alanine metabolism_Homo sapiens_hsa004100.56432677
89Alcoholism_Homo sapiens_hsa050340.56346490
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56157502
91Bile secretion_Homo sapiens_hsa049760.55164663
92Fatty acid biosynthesis_Homo sapiens_hsa000610.53979567
93Choline metabolism in cancer_Homo sapiens_hsa052310.53071680
94Inositol phosphate metabolism_Homo sapiens_hsa005620.52586536
95mTOR signaling pathway_Homo sapiens_hsa041500.51993949
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51990359
97Chemical carcinogenesis_Homo sapiens_hsa052040.51861064
98Insulin signaling pathway_Homo sapiens_hsa049100.51598500
99Protein export_Homo sapiens_hsa030600.50353669
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49732633
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.49343742
102RNA polymerase_Homo sapiens_hsa030200.48544738
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44528956
104Endocytosis_Homo sapiens_hsa041440.44364698
105Ras signaling pathway_Homo sapiens_hsa040140.44170382
106Peroxisome_Homo sapiens_hsa041460.44070617
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.44010142
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43823053
109Ovarian steroidogenesis_Homo sapiens_hsa049130.42264321
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42148232
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42115523
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41474944
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40484880
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39716040
115Prolactin signaling pathway_Homo sapiens_hsa049170.38571074
116Arachidonic acid metabolism_Homo sapiens_hsa005900.38250160
117Alzheimers disease_Homo sapiens_hsa050100.38203527
118Propanoate metabolism_Homo sapiens_hsa006400.37711886
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36426331
120Lysosome_Homo sapiens_hsa041420.36346649
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35990367
122Sulfur relay system_Homo sapiens_hsa041220.35903302
123Hedgehog signaling pathway_Homo sapiens_hsa043400.35857060
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34893868
125VEGF signaling pathway_Homo sapiens_hsa043700.33817280
126Butanoate metabolism_Homo sapiens_hsa006500.33677944
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.33157980
128Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31960877
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31647349
130Vitamin B6 metabolism_Homo sapiens_hsa007500.31231136
131Endometrial cancer_Homo sapiens_hsa052130.31195604
132Rap1 signaling pathway_Homo sapiens_hsa040150.31167856
133Retinol metabolism_Homo sapiens_hsa008300.30833218
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30349815
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29779640
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.29519195
137Renal cell carcinoma_Homo sapiens_hsa052110.28360348
138Wnt signaling pathway_Homo sapiens_hsa043100.27025814

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