DISP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.07094023
2nucleobase catabolic process (GO:0046113)5.57183929
3postsynaptic membrane organization (GO:0001941)5.10204891
4presynaptic membrane organization (GO:0097090)4.97536269
5axonal fasciculation (GO:0007413)4.75266783
6cell migration in hindbrain (GO:0021535)4.71289854
7presynaptic membrane assembly (GO:0097105)4.65681156
8neuron recognition (GO:0008038)4.59767298
9auditory behavior (GO:0031223)4.56269765
10neuron cell-cell adhesion (GO:0007158)4.29886856
11substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.26893956
12substrate-independent telencephalic tangential migration (GO:0021826)4.26893956
13regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.24636802
14establishment of mitochondrion localization (GO:0051654)4.23185457
15behavioral response to nicotine (GO:0035095)3.96186468
16synapse assembly (GO:0007416)3.83931355
17neuronal ion channel clustering (GO:0045161)3.83406490
18mechanosensory behavior (GO:0007638)3.81948602
19central nervous system projection neuron axonogenesis (GO:0021952)3.80645209
20ionotropic glutamate receptor signaling pathway (GO:0035235)3.79377563
21regulation of synapse structural plasticity (GO:0051823)3.77629977
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.75794109
23protein localization to synapse (GO:0035418)3.64627609
24cerebral cortex radially oriented cell migration (GO:0021799)3.61501780
25mitochondrion transport along microtubule (GO:0047497)3.59998374
26establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.59998374
27response to auditory stimulus (GO:0010996)3.59113571
28calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.56425291
29negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.55204081
30positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.50245824
31transmission of nerve impulse (GO:0019226)3.48699547
32regulation of short-term neuronal synaptic plasticity (GO:0048172)3.48103568
33synaptic transmission, glutamatergic (GO:0035249)3.46663320
34dendritic spine morphogenesis (GO:0060997)3.45500150
35neurotransmitter-gated ion channel clustering (GO:0072578)3.45254740
36positive regulation of growth hormone secretion (GO:0060124)3.41318698
37vocalization behavior (GO:0071625)3.39553639
38positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.32883486
39protein polyglutamylation (GO:0018095)3.32752562
40ganglion development (GO:0061548)3.30830942
41response to pheromone (GO:0019236)3.26671896
42synaptic vesicle maturation (GO:0016188)3.26519754
43layer formation in cerebral cortex (GO:0021819)3.23992490
44positive regulation of dendritic spine morphogenesis (GO:0061003)3.20974897
45spinal cord development (GO:0021510)3.19203630
46retinal ganglion cell axon guidance (GO:0031290)3.16965564
47glutamate receptor signaling pathway (GO:0007215)3.13100783
48regulation of growth hormone secretion (GO:0060123)3.12932986
49central nervous system neuron axonogenesis (GO:0021955)3.12800008
50locomotory exploration behavior (GO:0035641)3.09534520
51dendrite morphogenesis (GO:0048813)3.06687374
52negative regulation of cytosolic calcium ion concentration (GO:0051481)3.05360975
53positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.04946239
54regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.02624022
55adult walking behavior (GO:0007628)3.02410872
56cerebral cortex neuron differentiation (GO:0021895)3.00043504
57regulation of synaptic vesicle exocytosis (GO:2000300)2.99523681
58positive regulation of synapse assembly (GO:0051965)2.95633626
59G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95563140
60spinal cord association neuron differentiation (GO:0021527)2.92272842
61neuron-neuron synaptic transmission (GO:0007270)2.90226376
62synapse organization (GO:0050808)2.90035810
63acrosome reaction (GO:0007340)2.88634896
64neuromuscular synaptic transmission (GO:0007274)2.86585991
65exploration behavior (GO:0035640)2.86242594
66nonmotile primary cilium assembly (GO:0035058)2.86139337
67negative regulation of oligodendrocyte differentiation (GO:0048715)2.82996229
68adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.82974787
69sympathetic nervous system development (GO:0048485)2.81160019
70cranial nerve morphogenesis (GO:0021602)2.80948069
71regulation of synaptic transmission, glutamatergic (GO:0051966)2.80826298
72axon extension (GO:0048675)2.78815747
73axonemal dynein complex assembly (GO:0070286)2.78526785
74olfactory bulb development (GO:0021772)2.78467270
75neuron migration (GO:0001764)2.76152713
76hippocampus development (GO:0021766)2.75889407
77positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.73501220
78behavioral response to ethanol (GO:0048149)2.71201005
79regulation of glutamate receptor signaling pathway (GO:1900449)2.68653114
80startle response (GO:0001964)2.66392043
81sperm motility (GO:0030317)2.65434212
82calcium ion-dependent exocytosis (GO:0017156)2.63960372
83neurotransmitter secretion (GO:0007269)2.63172411
84positive regulation of synapse maturation (GO:0090129)2.62998449
85cell differentiation in spinal cord (GO:0021515)2.62305987
86peristalsis (GO:0030432)2.62297784
87central nervous system myelination (GO:0022010)2.61214613
88axon ensheathment in central nervous system (GO:0032291)2.61214613
89dendrite development (GO:0016358)2.60843005
90gamma-aminobutyric acid transport (GO:0015812)2.60700939
91positive regulation of dendritic spine development (GO:0060999)2.59834996
92regulation of respiratory system process (GO:0044065)2.59189941
93positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.58465621
94regulation of synaptic vesicle transport (GO:1902803)2.57051769
95membrane hyperpolarization (GO:0060081)2.56508877
96negative regulation of axonogenesis (GO:0050771)2.54012553
97nervous system development (GO:0007399)2.52967151
98membrane depolarization during action potential (GO:0086010)2.52267137
99positive regulation of oligodendrocyte differentiation (GO:0048714)2.52142066
100limb bud formation (GO:0060174)2.51622812

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.02042762
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.22157355
3EZH2_27304074_Chip-Seq_ESCs_Mouse2.81139040
4REST_21632747_ChIP-Seq_MESCs_Mouse2.71804022
5GBX2_23144817_ChIP-Seq_PC3_Human2.68596875
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68439746
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.67286365
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.62436187
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.53408051
10EZH2_27294783_Chip-Seq_ESCs_Mouse2.37757775
11SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32313168
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.31490937
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.27538653
14REST_18959480_ChIP-ChIP_MESCs_Mouse2.24627435
15RNF2_27304074_Chip-Seq_ESCs_Mouse2.21154824
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20558925
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17094929
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.15253258
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12607667
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12607667
21DROSHA_22980978_ChIP-Seq_HELA_Human2.08191149
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03655685
23IGF1R_20145208_ChIP-Seq_DFB_Human2.01634222
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95476366
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89466480
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87561510
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87010281
28RNF2_27304074_Chip-Seq_NSC_Mouse1.82261028
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78520824
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71207194
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70360836
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70169988
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.68918218
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67554830
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64860906
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.64122844
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63474835
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63109051
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.63109051
40OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.57615155
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.56496523
42ZNF274_21170338_ChIP-Seq_K562_Hela1.55675446
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52642489
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.51698350
45RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.48547561
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47746083
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.46413453
48RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.46258349
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43464580
50TAF15_26573619_Chip-Seq_HEK293_Human1.38692883
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37669155
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.36221476
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30962235
54RING1B_27294783_Chip-Seq_NPCs_Mouse1.29978355
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28227378
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26114094
57AR_21572438_ChIP-Seq_LNCaP_Human1.20860040
58TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19882595
59SMAD4_21799915_ChIP-Seq_A2780_Human1.17875876
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.15614457
61CTCF_27219007_Chip-Seq_Bcells_Human1.15095676
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14195592
63P300_19829295_ChIP-Seq_ESCs_Human1.10115145
64WDR5_24793694_ChIP-Seq_LNCAP_Human1.07630705
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.07543573
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.06737382
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05566725
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.05556714
69AR_25329375_ChIP-Seq_VCAP_Human1.02978645
70MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02227276
71FUS_26573619_Chip-Seq_HEK293_Human1.01844482
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01779934
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01656710
74AR_19668381_ChIP-Seq_PC3_Human1.00906483
75STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00143635
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00056892
77PIAS1_25552417_ChIP-Seq_VCAP_Human0.99830430
78SMAD3_21741376_ChIP-Seq_ESCs_Human0.99579250
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99427481
80SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97915430
81SOX2_21211035_ChIP-Seq_LN229_Gbm0.95789827
82KDM2B_26808549_Chip-Seq_K562_Human0.95319506
83POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94980798
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93633619
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91936833
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91350934
87CBP_20019798_ChIP-Seq_JUKART_Human0.91350934
88ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90270160
89STAT3_23295773_ChIP-Seq_U87_Human0.89271146
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88315812
91P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87974129
92POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87851967
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87750357
94SALL1_21062744_ChIP-ChIP_HESCs_Human0.87749286
95RUNX2_22187159_ChIP-Seq_PCA_Human0.87400531
96VDR_22108803_ChIP-Seq_LS180_Human0.86429492
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86024801
98WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85530295
99TCF4_23295773_ChIP-Seq_U87_Human0.85434601
100DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84834354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy4.28777921
2MP0004859_abnormal_synaptic_plasticity3.65900260
3MP0005423_abnormal_somatic_nervous3.46192514
4MP0000778_abnormal_nervous_system3.25422009
5MP0003880_abnormal_central_pattern3.09469215
6MP0004270_analgesia2.66613894
7MP0006276_abnormal_autonomic_nervous2.60125461
8MP0003635_abnormal_synaptic_transmissio2.40847818
9MP0002735_abnormal_chemical_nociception2.35780958
10MP0001529_abnormal_vocalization2.25083145
11MP0001188_hyperpigmentation2.07862803
12MP0002063_abnormal_learning/memory/cond2.03839697
13MP0002184_abnormal_innervation1.97322096
14MP0000955_abnormal_spinal_cord1.97108577
15MP0002734_abnormal_mechanical_nocicepti1.96126536
16MP0002638_abnormal_pupillary_reflex1.93494857
17MP0001968_abnormal_touch/_nociception1.92276496
18MP0001486_abnormal_startle_reflex1.91983431
19MP0002572_abnormal_emotion/affect_behav1.89367608
20MP0002653_abnormal_ependyma_morphology1.89106202
21MP0003122_maternal_imprinting1.88503555
22MP0004885_abnormal_endolymph1.87743471
23MP0009745_abnormal_behavioral_response1.87390659
24MP0003787_abnormal_imprinting1.85191450
25MP0002557_abnormal_social/conspecific_i1.84292922
26MP0005394_taste/olfaction_phenotype1.84232480
27MP0005499_abnormal_olfactory_system1.84232480
28MP0002272_abnormal_nervous_system1.81505079
29MP0006292_abnormal_olfactory_placode1.77346601
30MP0002736_abnormal_nociception_after1.76390752
31MP0002909_abnormal_adrenal_gland1.75882294
32MP0001984_abnormal_olfaction1.69948042
33MP0008789_abnormal_olfactory_epithelium1.69708432
34MP0005645_abnormal_hypothalamus_physiol1.67354711
35MP0002064_seizures1.65871175
36MP0002882_abnormal_neuron_morphology1.64823799
37MP0004811_abnormal_neuron_physiology1.62787554
38MP0000631_abnormal_neuroendocrine_gland1.57176796
39MP0003121_genomic_imprinting1.54071645
40MP0002067_abnormal_sensory_capabilities1.49963876
41MP0002733_abnormal_thermal_nociception1.46020486
42MP0005646_abnormal_pituitary_gland1.44691437
43MP0004742_abnormal_vestibular_system1.42730514
44MP0001970_abnormal_pain_threshold1.42256752
45MP0003878_abnormal_ear_physiology1.41518332
46MP0005377_hearing/vestibular/ear_phenot1.41518332
47MP0000049_abnormal_middle_ear1.39083402
48MP0002152_abnormal_brain_morphology1.37657325
49MP0003861_abnormal_nervous_system1.37184323
50MP0009046_muscle_twitch1.33595388
51MP0002752_abnormal_somatic_nervous1.31910593
52MP0001440_abnormal_grooming_behavior1.28088293
53MP0001485_abnormal_pinna_reflex1.25304496
54MP0002751_abnormal_autonomic_nervous1.23366187
55MP0004142_abnormal_muscle_tone1.18221272
56MP0000026_abnormal_inner_ear1.15299329
57MP0001905_abnormal_dopamine_level1.14708038
58MP0005551_abnormal_eye_electrophysiolog1.12835152
59MP0003938_abnormal_ear_development1.12599745
60MP0005253_abnormal_eye_physiology1.11747961
61MP0002234_abnormal_pharynx_morphology1.11630983
62MP0006072_abnormal_retinal_apoptosis1.11216449
63MP0004133_heterotaxia1.10894627
64MP0005386_behavior/neurological_phenoty1.10350824
65MP0004924_abnormal_behavior1.10350824
66MP0002249_abnormal_larynx_morphology1.09204863
67MP0003119_abnormal_digestive_system1.08602785
68MP0003123_paternal_imprinting1.07083222
69MP0000537_abnormal_urethra_morphology1.05378207
70MP0003890_abnormal_embryonic-extraembry1.04592498
71MP0002066_abnormal_motor_capabilities/c1.03946518
72MP0001502_abnormal_circadian_rhythm1.03044689
73MP0008569_lethality_at_weaning1.01144762
74MP0004145_abnormal_muscle_electrophysio0.96914039
75MP0002069_abnormal_eating/drinking_beha0.95971732
76MP0003698_abnormal_male_reproductive0.93139704
77MP0003879_abnormal_hair_cell0.92032249
78MP0001299_abnormal_eye_distance/0.91889133
79MP0000566_synostosis0.91709579
80MP0001963_abnormal_hearing_physiology0.89839349
81MP0005410_abnormal_fertilization0.87887317
82MP0003329_amyloid_beta_deposits0.87669984
83MP0005195_abnormal_posterior_eye0.87581219
84MP0003136_yellow_coat_color0.85269846
85MP0005670_abnormal_white_adipose0.82195464
86MP0002102_abnormal_ear_morphology0.82025991
87MP0008877_abnormal_DNA_methylation0.81710132
88MP0003633_abnormal_nervous_system0.81489903
89MP0002229_neurodegeneration0.80617469
90MP0005187_abnormal_penis_morphology0.79685732
91MP0003011_delayed_dark_adaptation0.79665449
92MP0002081_perinatal_lethality0.79346926
93MP0000534_abnormal_ureter_morphology0.78905879
94MP0002233_abnormal_nose_morphology0.78625563
95MP0003283_abnormal_digestive_organ0.76765387
96MP0003385_abnormal_body_wall0.75676606
97MP0005391_vision/eye_phenotype0.74704847
98MP0002163_abnormal_gland_morphology0.74404858
99MP0001986_abnormal_taste_sensitivity0.72834237
100MP0003631_nervous_system_phenotype0.69412441

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.67505892
2Hepatoblastoma (HP:0002884)3.17717538
3Drooling (HP:0002307)3.15280993
4Focal seizures (HP:0007359)3.13333645
5Abnormality of the aortic arch (HP:0012303)2.99115685
6Epileptic encephalopathy (HP:0200134)2.92017710
7Focal motor seizures (HP:0011153)2.88326701
8Pachygyria (HP:0001302)2.86888866
9Excessive salivation (HP:0003781)2.86303436
10Retinal dysplasia (HP:0007973)2.76992219
11Progressive cerebellar ataxia (HP:0002073)2.75827712
12Aplasia/Hypoplasia of the brainstem (HP:0007362)2.75174400
13Hypoplasia of the brainstem (HP:0002365)2.75174400
14Polyphagia (HP:0002591)2.72137833
15Lissencephaly (HP:0001339)2.64313459
16Amblyopia (HP:0000646)2.62163325
17Limb dystonia (HP:0002451)2.59327074
18Hyperventilation (HP:0002883)2.57846127
19Chronic hepatic failure (HP:0100626)2.57350699
20Short 4th metacarpal (HP:0010044)2.52366448
21Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.52366448
22Hypsarrhythmia (HP:0002521)2.48715430
23Nephronophthisis (HP:0000090)2.46983214
24Epileptiform EEG discharges (HP:0011182)2.42615677
25High anterior hairline (HP:0009890)2.42409249
26EEG with generalized epileptiform discharges (HP:0011198)2.41843733
27Abnormality of midbrain morphology (HP:0002418)2.39154663
28Molar tooth sign on MRI (HP:0002419)2.39154663
29Rib fusion (HP:0000902)2.38288343
30Cortical dysplasia (HP:0002539)2.38201832
31Abnormality of the lower motor neuron (HP:0002366)2.33786027
32Genetic anticipation (HP:0003743)2.32701973
33Gait imbalance (HP:0002141)2.30431012
34Anomalous pulmonary venous return (HP:0010772)2.24054231
35Abnormality of the 4th metacarpal (HP:0010012)2.23587747
36Broad-based gait (HP:0002136)2.21315137
37Abnormality of the labia minora (HP:0012880)2.20961258
38Febrile seizures (HP:0002373)2.19925496
39Bony spicule pigmentary retinopathy (HP:0007737)2.19885891
40Intestinal atresia (HP:0011100)2.18727173
41Oligodactyly (hands) (HP:0001180)2.15358730
42Megalencephaly (HP:0001355)2.13797954
43Agitation (HP:0000713)2.11362697
44Septo-optic dysplasia (HP:0100842)2.11117798
45Peripheral hypomyelination (HP:0007182)2.08947937
46Renal hypoplasia (HP:0000089)2.07928052
47Optic nerve hypoplasia (HP:0000609)2.04046557
48Abnormality of the corticospinal tract (HP:0002492)2.03867075
49Amyotrophic lateral sclerosis (HP:0007354)2.03252750
50Hypoplasia of the corpus callosum (HP:0002079)2.02587548
51Exotropia (HP:0000577)2.02427600
52Obsessive-compulsive behavior (HP:0000722)2.02138139
53Abnormality of the parathyroid morphology (HP:0011766)2.02009758
54Esotropia (HP:0000565)2.01472991
55Optic nerve coloboma (HP:0000588)1.99557295
56Abnormality of the renal medulla (HP:0100957)1.95555357
57Growth hormone deficiency (HP:0000824)1.95550274
58Oligodactyly (HP:0012165)1.95506578
59Urinary bladder sphincter dysfunction (HP:0002839)1.94238239
60Spastic tetraplegia (HP:0002510)1.92335806
61Specific learning disability (HP:0001328)1.91741442
62Cutaneous finger syndactyly (HP:0010554)1.90871103
63Absent speech (HP:0001344)1.90670434
64Abnormality of the intervertebral disk (HP:0005108)1.90245949
65Dynein arm defect of respiratory motile cilia (HP:0012255)1.88645853
66Absent/shortened dynein arms (HP:0200106)1.88645853
67Thyroid-stimulating hormone excess (HP:0002925)1.87773215
68Hemiparesis (HP:0001269)1.87716735
69Abnormal eating behavior (HP:0100738)1.87353753
70Narrow forehead (HP:0000341)1.86325532
71Atonic seizures (HP:0010819)1.85471456
72Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85107358
73Aqueductal stenosis (HP:0002410)1.84970552
74Abnormality of the pulmonary veins (HP:0011718)1.83031922
75Poor suck (HP:0002033)1.82768229
76Failure to thrive in infancy (HP:0001531)1.82321195
77Action tremor (HP:0002345)1.81946694
78Protruding tongue (HP:0010808)1.81934936
79Double outlet right ventricle (HP:0001719)1.81542502
80Congenital malformation of the right heart (HP:0011723)1.81542502
81Intellectual disability, severe (HP:0010864)1.78441683
82Spastic gait (HP:0002064)1.78112515
83Congenital primary aphakia (HP:0007707)1.77950637
84Poor coordination (HP:0002370)1.77315142
85Medial flaring of the eyebrow (HP:0010747)1.76900003
86Abnormality of the metopic suture (HP:0005556)1.76636781
87Polymicrogyria (HP:0002126)1.76274270
88Type II lissencephaly (HP:0007260)1.76268711
89Inability to walk (HP:0002540)1.73806958
90Ankle clonus (HP:0011448)1.72203695
91Nephrogenic diabetes insipidus (HP:0009806)1.71265579
92Cutaneous syndactyly (HP:0012725)1.69687459
93Anencephaly (HP:0002323)1.69523494
94Genital tract atresia (HP:0001827)1.68339754
95Shawl scrotum (HP:0000049)1.67985881
96Abnormal respiratory motile cilium morphology (HP:0005938)1.67914348
97Abnormal respiratory epithelium morphology (HP:0012253)1.67914348
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.67805125
99Hyperglycinemia (HP:0002154)1.67456367
100Pendular nystagmus (HP:0012043)1.67340642

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.44943036
2CASK4.56013421
3NTRK22.96165572
4MAP3K42.93844535
5DYRK22.64541974
6NTRK32.39216815
7CAMK1G2.36915993
8MAP2K72.36608076
9BCR2.28768030
10CAMK1D2.27207798
11SIK22.22343363
12WNK32.04215998
13EPHB21.97625501
14MAPK131.83501651
15TYRO31.83169285
16MINK11.77238084
17EPHA41.74227203
18INSRR1.52899272
19NTRK11.51844120
20MAP2K41.46945575
21TNIK1.46221885
22ICK1.37321610
23PNCK1.35439013
24PINK11.34020229
25CSNK1G21.33812375
26UHMK11.26919614
27SGK2231.26890694
28SGK4941.26890694
29PRKCG1.20183463
30MAP4K21.17623149
31CDK51.15838525
32PKN11.10648057
33BRD41.09273496
34MARK21.09267278
35CSNK1G31.08004709
36EPHA31.07316835
37TAOK11.05689251
38FGFR21.00559426
39DYRK1A0.99472205
40DYRK1B0.98867538
41CSNK1A1L0.97020337
42MAP3K60.96021651
43TNK20.95686366
44CDK90.92269492
45DAPK20.91933912
46WNK10.90667906
47TRIM280.87251589
48CAMKK10.84785218
49CSNK1G10.84417333
50PRKCZ0.83868767
51CAMK10.81890584
52RPS6KA20.80838812
53KSR10.79435782
54PAK30.79302855
55SGK20.78623216
56PAK60.76483386
57ERBB20.74851210
58CDK190.71965440
59PRKD30.69698455
60PLK40.69693630
61STK38L0.69672225
62PHKG20.65913218
63PHKG10.65913218
64CAMK2B0.65335899
65PRKAA10.64443724
66PLK20.63973388
67DYRK30.63648295
68STK110.63424826
69CDK140.60922081
70CAMK40.60551366
71CSNK1E0.59808765
72DDR20.58632470
73PRKCH0.57469654
74CDK11A0.57233844
75STK380.57083790
76CAMK2A0.56099707
77CDK180.55716325
78BMPR1B0.55264459
79CDK150.54587260
80ADRBK20.52795634
81ERBB30.50502691
82PRKCE0.48550442
83GSK3B0.46487829
84TESK10.46403921
85SGK10.45002396
86MKNK20.44882008
87AKT30.42919008
88MAPK150.41630797
89GRK10.41331711
90SGK30.41312061
91CDK30.40012335
92CSNK1D0.39518049
93PRKG10.38359718
94MAP3K90.38119351
95MAPK100.37722566
96MAPK80.37130214
97MAPK90.36923494
98PRKACA0.35340976
99RPS6KA30.34148767
100PRKDC0.32413300

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.55721408
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67524465
3GABAergic synapse_Homo sapiens_hsa047272.59619673
4Cocaine addiction_Homo sapiens_hsa050302.58009017
5Glutamatergic synapse_Homo sapiens_hsa047242.56828820
6Axon guidance_Homo sapiens_hsa043602.42770324
7Morphine addiction_Homo sapiens_hsa050322.39963784
8Circadian entrainment_Homo sapiens_hsa047132.39057970
9Synaptic vesicle cycle_Homo sapiens_hsa047212.28419566
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22351484
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.19434267
12Dopaminergic synapse_Homo sapiens_hsa047282.16765480
13Cholinergic synapse_Homo sapiens_hsa047251.91442583
14Insulin secretion_Homo sapiens_hsa049111.89925545
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71957478
16Taste transduction_Homo sapiens_hsa047421.68440958
17Type II diabetes mellitus_Homo sapiens_hsa049301.65679944
18Phototransduction_Homo sapiens_hsa047441.62394607
19Amphetamine addiction_Homo sapiens_hsa050311.57287511
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.52332453
21Cardiac muscle contraction_Homo sapiens_hsa042601.44993664
22Fatty acid biosynthesis_Homo sapiens_hsa000611.37530523
23Butanoate metabolism_Homo sapiens_hsa006501.37406284
24cAMP signaling pathway_Homo sapiens_hsa040241.35307147
25Long-term depression_Homo sapiens_hsa047301.34455266
26Serotonergic synapse_Homo sapiens_hsa047261.32898496
27Steroid biosynthesis_Homo sapiens_hsa001001.31889657
28Gap junction_Homo sapiens_hsa045401.31310883
29Notch signaling pathway_Homo sapiens_hsa043301.30202174
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24754125
31Basal cell carcinoma_Homo sapiens_hsa052171.22295867
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21375855
33Gastric acid secretion_Homo sapiens_hsa049711.10807989
34Olfactory transduction_Homo sapiens_hsa047401.10140762
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07080603
36Hedgehog signaling pathway_Homo sapiens_hsa043401.07060675
37Oxytocin signaling pathway_Homo sapiens_hsa049211.03829751
38Alcoholism_Homo sapiens_hsa050341.01315838
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00711316
40Long-term potentiation_Homo sapiens_hsa047200.95936278
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93007787
42Salivary secretion_Homo sapiens_hsa049700.92834677
43Hippo signaling pathway_Homo sapiens_hsa043900.85429785
44Melanogenesis_Homo sapiens_hsa049160.84350441
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83071727
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80143412
47Colorectal cancer_Homo sapiens_hsa052100.78741764
48Lysine degradation_Homo sapiens_hsa003100.78294360
49Regulation of autophagy_Homo sapiens_hsa041400.77538665
50Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77167817
51Calcium signaling pathway_Homo sapiens_hsa040200.75762090
52Estrogen signaling pathway_Homo sapiens_hsa049150.75613643
53ErbB signaling pathway_Homo sapiens_hsa040120.74522303
54Fatty acid metabolism_Homo sapiens_hsa012120.73756427
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72659678
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.71527852
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70670979
58Endometrial cancer_Homo sapiens_hsa052130.70209562
59Renin secretion_Homo sapiens_hsa049240.68856664
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68148929
61AMPK signaling pathway_Homo sapiens_hsa041520.66125299
62Wnt signaling pathway_Homo sapiens_hsa043100.65128462
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65053979
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65047850
65Rap1 signaling pathway_Homo sapiens_hsa040150.62225887
66Dilated cardiomyopathy_Homo sapiens_hsa054140.60425502
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60166242
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59961701
69Ras signaling pathway_Homo sapiens_hsa040140.59658474
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57913034
71Thyroid hormone synthesis_Homo sapiens_hsa049180.57182190
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57072839
73Dorso-ventral axis formation_Homo sapiens_hsa043200.54618500
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53864038
75MAPK signaling pathway_Homo sapiens_hsa040100.53380468
76Choline metabolism in cancer_Homo sapiens_hsa052310.52826411
77Parkinsons disease_Homo sapiens_hsa050120.52416902
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.51878014
79ABC transporters_Homo sapiens_hsa020100.51297871
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.50235863
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49127371
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48767455
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47318993
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46974974
85mTOR signaling pathway_Homo sapiens_hsa041500.46697469
86Prolactin signaling pathway_Homo sapiens_hsa049170.46140981
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45502062
88Ether lipid metabolism_Homo sapiens_hsa005650.44811810
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.44606885
90Glioma_Homo sapiens_hsa052140.43422000
91Basal transcription factors_Homo sapiens_hsa030220.43098545
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42541442
93Oocyte meiosis_Homo sapiens_hsa041140.42391666
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41385763
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41272250
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40090821
97Vibrio cholerae infection_Homo sapiens_hsa051100.39396541
98Tight junction_Homo sapiens_hsa045300.38178290
99Propanoate metabolism_Homo sapiens_hsa006400.37070519
100Bile secretion_Homo sapiens_hsa049760.36442236

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