DKK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peripheral nervous system neuron development (GO:0048935)9.58298890
2generation of neurons (GO:0048699)7.26525159
3central nervous system myelination (GO:0022010)6.99632224
4axon ensheathment in central nervous system (GO:0032291)6.99632224
5mesenchyme morphogenesis (GO:0072132)6.53358808
6regulation of secondary heart field cardioblast proliferation (GO:0003266)6.41905540
7regulation of cardioblast proliferation (GO:0003264)6.41905540
8endocardial cushion morphogenesis (GO:0003203)6.28365040
9myoblast migration (GO:0051451)6.04345380
10regulation of heart morphogenesis (GO:2000826)6.00239445
11negative regulation of catenin import into nucleus (GO:0035414)5.99011037
12proximal/distal pattern formation (GO:0009954)5.90946493
13planar cell polarity pathway involved in neural tube closure (GO:0090179)5.80311724
14G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071995.59765671
15cell migration involved in heart development (GO:0060973)5.44019685
16regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)5.32879895
17segment specification (GO:0007379)5.08720406
18limb bud formation (GO:0060174)4.98489268
19hindlimb morphogenesis (GO:0035137)4.95154659
20axon extension involved in axon guidance (GO:0048846)4.79921450
21neuron projection extension involved in neuron projection guidance (GO:1902284)4.79921450
22organ induction (GO:0001759)4.69876388
23lateral sprouting from an epithelium (GO:0060601)4.59206792
24middle ear morphogenesis (GO:0042474)4.58916322
25regulation of cardioblast differentiation (GO:0051890)4.53328650
26collagen fibril organization (GO:0030199)4.41206590
27outflow tract septum morphogenesis (GO:0003148)4.40798884
28neuron fate specification (GO:0048665)4.34226442
29aorta morphogenesis (GO:0035909)4.23902187
30cranial suture morphogenesis (GO:0060363)4.21518584
31positive regulation of gastrulation (GO:2000543)4.21056686
32glomerular basement membrane development (GO:0032836)4.15358641
33limb development (GO:0060173)4.10882914
34appendage development (GO:0048736)4.10882914
35embryonic skeletal system morphogenesis (GO:0048704)4.09532832
36prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.09089066
37negative regulation of embryonic development (GO:0045992)4.06707106
38outer ear morphogenesis (GO:0042473)4.04011348
39myelination (GO:0042552)4.01884267
40ensheathment of neurons (GO:0007272)3.99307138
41axon ensheathment (GO:0008366)3.99307138
42skeletal muscle tissue development (GO:0007519)3.93080672
43regulation of organ formation (GO:0003156)3.89515518
44embryonic skeletal joint morphogenesis (GO:0060272)3.87403416
45Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.82211962
46glomerular visceral epithelial cell development (GO:0072015)3.81928482
47long-chain fatty acid biosynthetic process (GO:0042759)3.76091916
48positive regulation of embryonic development (GO:0040019)3.75117286
49regulation of transforming growth factor beta2 production (GO:0032909)3.74458930
50fatty acid elongation (GO:0030497)3.69155259
51non-canonical Wnt signaling pathway (GO:0035567)3.65692232
52cochlea morphogenesis (GO:0090103)3.65632301
53glomerular epithelial cell development (GO:0072310)3.62851758
54regulation of establishment of planar polarity (GO:0090175)3.61953447
55regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.61894184
56neuron remodeling (GO:0016322)3.61067617
57embryonic cranial skeleton morphogenesis (GO:0048701)3.60480929
58craniofacial suture morphogenesis (GO:0097094)3.59007272
59muscle cell proliferation (GO:0033002)3.56717560
60cornea development in camera-type eye (GO:0061303)3.46728741
61positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.44967998
62negative regulation of axon guidance (GO:1902668)3.43829797
63embryonic appendage morphogenesis (GO:0035113)3.42488078
64embryonic limb morphogenesis (GO:0030326)3.42488078
65skeletal system morphogenesis (GO:0048705)3.41020197
66cerebral cortex radially oriented cell migration (GO:0021799)3.41002334
67regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.37939871
68negative regulation of protein localization to cell surface (GO:2000009)3.36509907
69embryonic organ morphogenesis (GO:0048562)3.34141288
70cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.32877845
71mammary gland development (GO:0030879)3.31934703
72presynaptic membrane assembly (GO:0097105)3.31073595
73cardiac muscle cell proliferation (GO:0060038)3.30559366
74muscle cell migration (GO:0014812)3.29383790
75lymph vessel development (GO:0001945)3.29371864
76positive regulation of fatty acid beta-oxidation (GO:0032000)3.29020224
77striated muscle tissue development (GO:0014706)3.28660626
78ganglion development (GO:0061548)3.27070082
79presynaptic membrane organization (GO:0097090)3.25077031
80outflow tract morphogenesis (GO:0003151)3.24105038
81palate development (GO:0060021)3.23278079
82gland morphogenesis (GO:0022612)3.22497506
83negative regulation of axon extension involved in axon guidance (GO:0048843)3.22169690
84artery smooth muscle contraction (GO:0014824)3.21057726
85keratan sulfate catabolic process (GO:0042340)3.20970460
86positive regulation of transcription regulatory region DNA binding (GO:2000679)3.20008086
87embryonic digestive tract development (GO:0048566)3.16953393
88positive regulation of protein kinase C signaling (GO:0090037)3.16906467
89eye photoreceptor cell differentiation (GO:0001754)3.15153488
90photoreceptor cell differentiation (GO:0046530)3.15153488
91import into cell (GO:0098657)3.14837691
92eye morphogenesis (GO:0048592)3.14507755
93positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.13848846
94muscle tissue development (GO:0060537)3.13099620
95branch elongation of an epithelium (GO:0060602)3.12462098
96organ growth (GO:0035265)3.10312856
97L-amino acid import (GO:0043092)3.09767548
98cranial nerve morphogenesis (GO:0021602)3.09642747
99peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.08329790
100short-term memory (GO:0007614)3.08103628
101glomerulus development (GO:0032835)3.04658423
102embryonic hindlimb morphogenesis (GO:0035116)3.02451270
103cell-cell signaling involved in cell fate commitment (GO:0045168)3.02162501
104positive regulation of odontogenesis (GO:0042482)3.01825682
105limb morphogenesis (GO:0035108)3.01711657
106appendage morphogenesis (GO:0035107)3.01711657
107positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.99326984
108negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.97853347
109nephron tubule formation (GO:0072079)2.97736558
110somatic stem cell division (GO:0048103)2.97461435
111neuron recognition (GO:0008038)2.96947923
112glandular epithelial cell development (GO:0002068)2.96500631
113negative regulation of DNA repair (GO:0045738)2.96039134
114myelination in peripheral nervous system (GO:0022011)2.95386204
115peripheral nervous system axon ensheathment (GO:0032292)2.95386204
116ureteric bud development (GO:0001657)2.93116322
117smooth muscle cell differentiation (GO:0051145)2.93042330
118positive regulation of oligodendrocyte differentiation (GO:0048714)2.90375164
119mesenchymal cell differentiation involved in renal system development (GO:2001012)2.88350356
120mesenchymal cell differentiation involved in kidney development (GO:0072161)2.88350356
121negative regulation of neurotransmitter transport (GO:0051589)2.86674417
122retina layer formation (GO:0010842)2.86079107
123oligodendrocyte differentiation (GO:0048709)2.84136623
124regulation of axon guidance (GO:1902667)2.82130934
125embryonic forelimb morphogenesis (GO:0035115)2.78165017
126axonal fasciculation (GO:0007413)2.75471033
127regulation of mesenchymal cell apoptotic process (GO:2001053)2.74930723
128retina vasculature morphogenesis in camera-type eye (GO:0061299)2.74445751
129neuron cell-cell adhesion (GO:0007158)2.74051961
130negative regulation of neurotransmitter secretion (GO:0046929)2.71133871
131regulation of pigment cell differentiation (GO:0050932)2.70879769
132astrocyte development (GO:0014002)2.67597869
133regulation of collateral sprouting (GO:0048670)2.65820816
134virion attachment to host cell (GO:0019062)2.65479944
135adhesion of symbiont to host cell (GO:0044650)2.65479944
136forelimb morphogenesis (GO:0035136)2.63586278
137mesenchymal cell proliferation (GO:0010463)2.62655413
138regulation of somitogenesis (GO:0014807)2.61415694
139regulation of axon extension involved in axon guidance (GO:0048841)2.60908354
140head development (GO:0060322)2.59829340
141regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.58157253
142negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.54837140
143negative regulation of axon extension (GO:0030517)2.53504388
144cell proliferation involved in kidney development (GO:0072111)2.52321004
145mesonephros development (GO:0001823)2.50464234
146asymmetric protein localization (GO:0008105)2.50112106
147bone trabecula formation (GO:0060346)2.49939717
148cranial nerve development (GO:0021545)2.49180078
149apical protein localization (GO:0045176)2.48575900
150mesenchymal-epithelial cell signaling (GO:0060638)2.48562432
151somite development (GO:0061053)2.47485563
152negative regulation of leukocyte chemotaxis (GO:0002689)2.46251449
153regulation of glomerulus development (GO:0090192)2.42126697
154positive regulation of action potential (GO:0045760)2.41782278
155amino acid import (GO:0043090)2.41593025
156cell differentiation involved in kidney development (GO:0061005)2.41078217
157cerebral cortex cell migration (GO:0021795)2.41075472
158kidney mesenchyme development (GO:0072074)2.40587618
159chondrocyte development (GO:0002063)2.40227132
160myelin maintenance (GO:0043217)2.39655775
161mesodermal cell differentiation (GO:0048333)2.38988316
162regulation of timing of cell differentiation (GO:0048505)2.38883941
163negative regulation of myoblast differentiation (GO:0045662)2.37860608
164negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.37851967
165metanephric mesenchyme development (GO:0072075)2.35220786
166neuronal action potential propagation (GO:0019227)2.34143479
167response to redox state (GO:0051775)2.34022235
168otic vesicle formation (GO:0030916)2.33310813
169axis elongation (GO:0003401)2.32574914
170positive regulation of smooth muscle cell migration (GO:0014911)2.32001608
171cranial nerve structural organization (GO:0021604)2.31885853
172positive regulation of synapse assembly (GO:0051965)2.31511206
173mesenchymal cell differentiation (GO:0048762)2.31000115
174negative regulation of execution phase of apoptosis (GO:1900118)2.30104712
175enteric nervous system development (GO:0048484)2.29568432
176regulation of mesenchymal cell proliferation (GO:0010464)2.28925600
177cell proliferation involved in metanephros development (GO:0072203)2.28872435
178regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.28435430
179glomerular filtration (GO:0003094)2.28430057
180anatomical structure arrangement (GO:0048532)2.28278693
181peptidyl-tyrosine autophosphorylation (GO:0038083)2.27870756
182dendritic spine morphogenesis (GO:0060997)2.27425588
183dopamine biosynthetic process (GO:0042416)2.26878652
184extracellular regulation of signal transduction (GO:1900115)2.25083784

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.67180954
2GBX2_23144817_ChIP-Seq_PC3_Human3.07579303
3* EED_16625203_ChIP-ChIP_MESCs_Mouse2.87031742
4TP63_19390658_ChIP-ChIP_HaCaT_Human2.86080102
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83256440
6CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.72577293
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.70076188
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66736005
9* EZH2_27304074_Chip-Seq_ESCs_Mouse2.66520892
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56326600
11* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55638647
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53046154
13* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53046154
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43466559
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33058361
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.30023935
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.25248019
18* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.23344454
19* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.12533776
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12192233
21TAF15_26573619_Chip-Seq_HEK293_Human2.10384541
22* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.06081884
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04947688
24* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.02007000
25* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98715886
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.97682612
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.97155031
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93902006
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.93648859
30* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.93022177
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92152397
32VDR_22108803_ChIP-Seq_LS180_Human1.85815459
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.84069942
34AR_21572438_ChIP-Seq_LNCaP_Human1.81465479
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.78958209
36* WT1_19549856_ChIP-ChIP_CCG9911_Human1.77251305
37* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76649813
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76428506
39ISL1_27105846_Chip-Seq_CPCs_Mouse1.75323401
40* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72981164
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.72746261
42STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.69135590
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67835482
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64420336
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60062851
46* P300_19829295_ChIP-Seq_ESCs_Human1.57202378
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56756593
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51843136
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51156304
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51079992
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.51061525
52RNF2_27304074_Chip-Seq_NSC_Mouse1.50837247
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49403930
54ER_23166858_ChIP-Seq_MCF-7_Human1.48527479
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.45971136
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.45012284
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42527197
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41696947
59* TP53_18474530_ChIP-ChIP_U2OS_Human1.40285286
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.35731269
61TP53_20018659_ChIP-ChIP_R1E_Mouse1.30632063
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29576010
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.29565435
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29209326
65KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.28437226
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28293356
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28221460
68* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25776785
69* SMAD4_21799915_ChIP-Seq_A2780_Human1.24425687
70* NANOG_18555785_Chip-Seq_ESCs_Mouse1.24180644
71SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.23715384
72* FUS_26573619_Chip-Seq_HEK293_Human1.23679887
73IGF1R_20145208_ChIP-Seq_DFB_Human1.23025111
74* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22974253
75TP53_16413492_ChIP-PET_HCT116_Human1.21937342
76* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18024541
77RING1B_27294783_Chip-Seq_NPCs_Mouse1.17503695
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17438446
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.17362761
80* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17152622
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17139554
82ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16465076
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16147170
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15556520
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14772271
86AHR_22903824_ChIP-Seq_MCF-7_Human1.14445991
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13457077
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13457077
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13391512
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.12399713
91DROSHA_22980978_ChIP-Seq_HELA_Human1.10963462
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.10808162
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10220558
94* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09838791
95* RING1B_27294783_Chip-Seq_ESCs_Mouse1.09467490
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09343008
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08563713
98TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08535761
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08407884
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08332326
101SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07370834
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06206478
103STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06146472
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06136471
105HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05720718
106* CMYC_18555785_Chip-Seq_ESCs_Mouse1.05028266
107* E2F1_18555785_Chip-Seq_ESCs_Mouse1.04421793
108P53_22387025_ChIP-Seq_ESCs_Mouse1.02912267
109* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02447929
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01798969
111* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00911566
112* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00565454
113* RUNX2_22187159_ChIP-Seq_PCA_Human0.99946145
114CJUN_26792858_Chip-Seq_BT549_Human0.99214264
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98707494
116EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98623847
117KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97877139
118KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97877139
119KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97877139
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97368163
121* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97218195
122ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96954369
123EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96073401
124EZH2_27294783_Chip-Seq_NPCs_Mouse0.95906244
125P300_18555785_Chip-Seq_ESCs_Mouse0.95489071
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95389727
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95389727
128* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93994869
129WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92704714
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86607285
131SA1_22415368_ChIP-Seq_MEFs_Mouse0.86175373
132SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85251122
133SOX9_26525672_Chip-Seq_HEART_Mouse0.83451006
134SOX2_16153702_ChIP-ChIP_HESCs_Human0.81660665
135TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.81385924
136FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.76828826
137KDM2B_26808549_Chip-Seq_REH_Human0.76755738
138TBX3_20139965_ChIP-Seq_MESCs_Mouse0.76233235
139NANOG_16153702_ChIP-ChIP_HESCs_Human0.75358411
140TBX3_20139965_ChIP-Seq_ESCs_Mouse0.75305791
141OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.73452079
142SMC1_22415368_ChIP-Seq_MEFs_Mouse0.72323718
143HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.69937711
144IKZF1_21737484_ChIP-ChIP_HCT116_Human0.69206562
145LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67348160
146MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.66815161
147NR3C1_23031785_ChIP-Seq_PC12_Mouse0.65936024
148DNAJC2_21179169_ChIP-ChIP_NT2_Human0.64199074

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.59975959
2MP0002102_abnormal_ear_morphology3.03668605
3MP0000566_synostosis2.99844656
4MP0005503_abnormal_tendon_morphology2.72765755
5MP0005409_darkened_coat_color2.58896895
6MP0005171_absent_coat_pigmentation2.58594043
7MP0008438_abnormal_cutaneous_collagen2.52448966
8MP0003880_abnormal_central_pattern2.45385499
9MP0009250_abnormal_appendicular_skeleto2.45165137
10MP0000920_abnormal_myelination2.42881103
11MP0004742_abnormal_vestibular_system2.35619904
12MP0000733_abnormal_muscle_development2.30049811
13MP0003938_abnormal_ear_development2.19675586
14MP0004272_abnormal_basement_membrane2.10848791
15MP0005623_abnormal_meninges_morphology2.05655612
16MP0009384_cardiac_valve_regurgitation1.98357434
17MP0003937_abnormal_limbs/digits/tail_de1.96308649
18MP0003385_abnormal_body_wall1.94134532
19MP0008789_abnormal_olfactory_epithelium1.91209246
20MP0002249_abnormal_larynx_morphology1.91183435
21MP0003950_abnormal_plasma_membrane1.89929023
22MP0002009_preneoplasia1.89051155
23MP0000049_abnormal_middle_ear1.88327726
24MP0001188_hyperpigmentation1.82408349
25MP0001177_atelectasis1.80763257
26MP0001486_abnormal_startle_reflex1.79148926
27MP0000462_abnormal_digestive_system1.77506606
28MP0000778_abnormal_nervous_system1.74702355
29MP0000383_abnormal_hair_follicle1.72285985
30MP0005248_abnormal_Harderian_gland1.72209417
31MP0004133_heterotaxia1.71879297
32MP0004134_abnormal_chest_morphology1.70721600
33MP0000762_abnormal_tongue_morphology1.68550045
34MP0000537_abnormal_urethra_morphology1.65762239
35MP0004381_abnormal_hair_follicle1.64100204
36MP0000372_irregular_coat_pigmentation1.61947725
37MP0000026_abnormal_inner_ear1.60383724
38MP0005197_abnormal_uvea_morphology1.56623928
39MP0001661_extended_life_span1.55617657
40MP0003115_abnormal_respiratory_system1.52752413
41MP0002396_abnormal_hematopoietic_system1.49528007
42MP0003878_abnormal_ear_physiology1.46531719
43MP0005377_hearing/vestibular/ear_phenot1.46531719
44MP0002114_abnormal_axial_skeleton1.42632206
45MP0002751_abnormal_autonomic_nervous1.41185900
46MP0002295_abnormal_pulmonary_circulatio1.37896941
47MP0003755_abnormal_palate_morphology1.37471743
48MP0001905_abnormal_dopamine_level1.37388884
49MP0009053_abnormal_anal_canal1.36767216
50MP0002233_abnormal_nose_morphology1.36645248
51MP0008260_abnormal_autophagy1.36176016
52MP0002938_white_spotting1.36063330
53MP0001958_emphysema1.35190426
54MP0005508_abnormal_skeleton_morphology1.33795338
55MP0005275_abnormal_skin_tensile1.33027105
56MP0004885_abnormal_endolymph1.31649348
57MP0001485_abnormal_pinna_reflex1.30899174
58MP0003942_abnormal_urinary_system1.30675759
59MP0010678_abnormal_skin_adnexa1.27261783
60MP0009379_abnormal_foot_pigmentation1.26140674
61MP0002282_abnormal_trachea_morphology1.25608545
62MP0002272_abnormal_nervous_system1.24288610
63MP0001299_abnormal_eye_distance/1.23221557
64MP0001963_abnormal_hearing_physiology1.22305243
65MP0001346_abnormal_lacrimal_gland1.22190068
66MP0003690_abnormal_glial_cell1.22003016
67MP0001529_abnormal_vocalization1.20576818
68MP0006292_abnormal_olfactory_placode1.20440938
69MP0003705_abnormal_hypodermis_morpholog1.17737286
70MP0002177_abnormal_outer_ear1.16751550
71MP0001879_abnormal_lymphatic_vessel1.16531620
72MP0001270_distended_abdomen1.16444601
73MP0003283_abnormal_digestive_organ1.15253196
74MP0000467_abnormal_esophagus_morphology1.14585445
75MP0001286_abnormal_eye_development1.14050456
76MP0002932_abnormal_joint_morphology1.12919142
77MP0010030_abnormal_orbit_morphology1.12401856
78MP0004270_analgesia1.10895400
79MP0003634_abnormal_glial_cell1.10542531
80MP0002184_abnormal_innervation1.10196090
81MP0003279_aneurysm1.09724556
82MP0002116_abnormal_craniofacial_bone1.09299100
83MP0000759_abnormal_skeletal_muscle1.06946387
84MP0005423_abnormal_somatic_nervous1.06483517
85MP0000163_abnormal_cartilage_morphology1.03957173
86MP0000647_abnormal_sebaceous_gland1.03913034
87MP0004142_abnormal_muscle_tone1.03746451
88MP0001340_abnormal_eyelid_morphology1.03262493
89MP0003119_abnormal_digestive_system1.03196692
90MP0000534_abnormal_ureter_morphology1.03037300
91MP0002064_seizures1.02865310
92MP0002752_abnormal_somatic_nervous1.01216473
93MP0000631_abnormal_neuroendocrine_gland1.00355039
94* MP0002113_abnormal_skeleton_development0.98885107
95MP0005595_abnormal_vascular_smooth0.98302797
96MP0000432_abnormal_head_morphology0.95732713
97MP0002108_abnormal_muscle_morphology0.95406678
98MP0004145_abnormal_muscle_electrophysio0.95365724
99MP0006072_abnormal_retinal_apoptosis0.93558447
100MP0005551_abnormal_eye_electrophysiolog0.92398594
101MP0009745_abnormal_behavioral_response0.92186739
102MP0005257_abnormal_intraocular_pressure0.91349361
103MP0003315_abnormal_perineum_morphology0.91215945
104MP0003941_abnormal_skin_development0.90197975
105MP0002111_abnormal_tail_morphology0.89824474
106MP0002697_abnormal_eye_size0.89054191
107MP0006276_abnormal_autonomic_nervous0.88198177
108MP0000428_abnormal_craniofacial_morphol0.87413304
109MP0000579_abnormal_nail_morphology0.86663302
110MP0002109_abnormal_limb_morphology0.86409826
111MP0005390_skeleton_phenotype0.85597908
112MP0005195_abnormal_posterior_eye0.83601004
113MP0002098_abnormal_vibrissa_morphology0.83532436
114MP0002067_abnormal_sensory_capabilities0.82578968
115MP0002882_abnormal_neuron_morphology0.81781175
116MP0009046_muscle_twitch0.81410477
117MP0003567_abnormal_fetal_cardiomyocyte0.81255713
118* MP0005193_abnormal_anterior_eye0.80896942
119MP0010368_abnormal_lymphatic_system0.80802051
120MP0003935_abnormal_craniofacial_develop0.80783105
121MP0003635_abnormal_synaptic_transmissio0.80653026
122MP0002127_abnormal_cardiovascular_syste0.79934436
123MP0001440_abnormal_grooming_behavior0.79333709
124MP0000613_abnormal_salivary_gland0.78526568
125MP0002115_abnormal_skeleton_extremities0.77923845
126MP0003122_maternal_imprinting0.77720279
127MP0002734_abnormal_mechanical_nocicepti0.77041084
128MP0002277_abnormal_respiratory_mucosa0.76851753
129MP0000955_abnormal_spinal_cord0.74170241
130MP0005388_respiratory_system_phenotype0.69305770
131MP0002133_abnormal_respiratory_system0.69305770
132MP0003861_abnormal_nervous_system0.68685772
133MP0000767_abnormal_smooth_muscle0.68314984
134MP0005187_abnormal_penis_morphology0.67440421
135MP0002085_abnormal_embryonic_tissue0.66176509
136MP0001542_abnormal_bone_strength0.65563274
137MP0002081_perinatal_lethality0.65158927
138MP0008961_abnormal_basal_metabolism0.64534362
139MP0005369_muscle_phenotype0.62981099
140MP0001502_abnormal_circadian_rhythm0.59748986
141MP0005499_abnormal_olfactory_system0.59548993
142MP0005394_taste/olfaction_phenotype0.59548993
143MP0001943_abnormal_respiration0.59089661

Predicted human phenotypes

RankGene SetZ-score
1Calcaneovalgus deformity (HP:0001848)6.72750295
2Deformed tarsal bones (HP:0008119)6.52825671
3Aortic dissection (HP:0002647)5.22505874
4Turricephaly (HP:0000262)4.80501404
5Shallow orbits (HP:0000586)4.35662210
6Abnormality of the calcaneus (HP:0008364)4.27855835
7Midline defect of the nose (HP:0004122)4.25217919
8Arterial tortuosity (HP:0005116)4.22749710
9Bladder diverticulum (HP:0000015)4.03770595
10Soft skin (HP:0000977)3.98839107
11Parakeratosis (HP:0001036)3.86564446
12Fragile skin (HP:0001030)3.75553483
13Peritonitis (HP:0002586)3.69278636
14Buphthalmos (HP:0000557)3.63053973
15Septo-optic dysplasia (HP:0100842)3.58250487
16Abnormality of the phalanges of the hallux (HP:0010057)3.58166335
17Protrusio acetabuli (HP:0003179)3.56894029
18Genu recurvatum (HP:0002816)3.55537607
19Mitral valve prolapse (HP:0001634)3.39947482
20Spondylolisthesis (HP:0003302)3.38482082
21Hallux valgus (HP:0001822)3.36300014
22Degeneration of the lateral corticospinal tracts (HP:0002314)3.32646494
23Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.32646494
24Deviation of the hallux (HP:0010051)3.28918861
25Bowel diverticulosis (HP:0005222)3.23349064
26Aplasia involving bones of the extremities (HP:0009825)3.21970024
27Aplasia involving bones of the upper limbs (HP:0009823)3.21970024
28Aplasia of the phalanges of the hand (HP:0009802)3.21970024
29Concave nail (HP:0001598)3.21934960
30Synostosis involving the elbow (HP:0003938)3.18500462
31Humeroradial synostosis (HP:0003041)3.18500462
32Premature rupture of membranes (HP:0001788)3.12389401
33Neurofibrillary tangles (HP:0002185)3.11886557
34Lip pit (HP:0100267)3.08312271
35White forelock (HP:0002211)3.06086277
36Absent septum pellucidum (HP:0001331)2.96663180
37Aplasia cutis congenita (HP:0001057)2.94169940
38Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.93914172
39Hypoplasia of the iris (HP:0007676)2.92622495
40Chin dimple (HP:0010751)2.92047112
41Patchy hypopigmentation of hair (HP:0011365)2.90001594
42Shawl scrotum (HP:0000049)2.89898916
43Abnormality of the phalanges of the 2nd finger (HP:0009541)2.81159403
44Alacrima (HP:0000522)2.77757387
45Broad distal phalanx of finger (HP:0009836)2.76447339
46Morphological abnormality of the middle ear (HP:0008609)2.75335875
47Congenital glaucoma (HP:0001087)2.73450753
48Abnormality of the middle phalanges of the toes (HP:0010183)2.69702887
49Coronal craniosynostosis (HP:0004440)2.67758930
50Abnormality of the septum pellucidum (HP:0007375)2.63216629
51Nasolacrimal duct obstruction (HP:0000579)2.62167114
52Dynein arm defect of respiratory motile cilia (HP:0012255)2.52345140
53Absent/shortened dynein arms (HP:0200106)2.52345140
54Metabolic alkalosis (HP:0200114)2.50146050
55Partial duplication of the phalanx of hand (HP:0009999)2.47009622
56Hyperextensible skin (HP:0000974)2.40987235
57Hypomagnesemia (HP:0002917)2.38822466
58Partial duplication of thumb phalanx (HP:0009944)2.38185439
59Flat cornea (HP:0007720)2.36222383
60Sensory axonal neuropathy (HP:0003390)2.35464845
61Fused cervical vertebrae (HP:0002949)2.35442495
62Abnormality of the nasolacrimal system (HP:0000614)2.31174318
63Peripheral hypomyelination (HP:0007182)2.30931414
64Symphalangism affecting the phalanges of the hand (HP:0009773)2.30560812
65Onion bulb formation (HP:0003383)2.29782551
66Increased corneal curvature (HP:0100692)2.29112269
67Keratoconus (HP:0000563)2.29112269
68Abnormality of dentin (HP:0010299)2.28372747
69Aplasia/Hypoplasia of the lens (HP:0008063)2.27461988
70Atrioventricular block (HP:0001678)2.26895892
71Broad toe (HP:0001837)2.26779775
72Broad hallux (HP:0010055)2.25343538
73Decreased lacrimation (HP:0000633)2.25206840
74Abnormality of the radial head (HP:0003995)2.24843401
75Abnormality of the parietal bone (HP:0002696)2.23930692
76Ectopia lentis (HP:0001083)2.23320541
77Hypoplastic pelvis (HP:0008839)2.22836325
78Increased circulating renin level (HP:0000848)2.22573430
79Long nose (HP:0003189)2.20271707
80Retinal dysplasia (HP:0007973)2.18993739
81Congenital sensorineural hearing impairment (HP:0008527)2.17264133
82Abnormality of the lacrimal duct (HP:0011481)2.16950359
83Wide anterior fontanel (HP:0000260)2.16593814
84Conical tooth (HP:0000698)2.15923632
85Bell-shaped thorax (HP:0001591)2.15364574
86Short hallux (HP:0010109)2.14343869
87Mixed hearing impairment (HP:0000410)2.14156117
88Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.13934077
89Dilatation of the ascending aorta (HP:0005111)2.12869944
90Cupped ear (HP:0000378)2.11724835
91Blue sclerae (HP:0000592)2.10827960
92Cervical subluxation (HP:0003308)2.10475361
93Abnormality of the 4th metacarpal (HP:0010012)2.09620782
94Hypophosphatemic rickets (HP:0004912)2.09111651
95Abnormality of the 2nd finger (HP:0004100)2.09079419
96Short 4th metacarpal (HP:0010044)2.08642243
97Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.08642243
98Upper limb muscle weakness (HP:0003484)2.06907457
99Abnormality of the humeroradial joint (HP:0100744)2.05508538
100Stage 5 chronic kidney disease (HP:0003774)2.04378821
101Abnormal ciliary motility (HP:0012262)2.00303544
102Preaxial foot polydactyly (HP:0001841)1.99886472
103Narrow palate (HP:0000189)1.98684795
104Overfolded helix (HP:0000396)1.97599464
105Narrow nasal bridge (HP:0000446)1.96306688
106Cerebral inclusion bodies (HP:0100314)1.95858957
107Joint laxity (HP:0001388)1.95506808
108Camptodactyly of toe (HP:0001836)1.94955276
109Adrenal hypoplasia (HP:0000835)1.94638311
110Atresia of the external auditory canal (HP:0000413)1.93857578
111Aplasia/Hypoplasia of the clavicles (HP:0006710)1.93097377
112Pterygium (HP:0001059)1.92179564
113Cupped ribs (HP:0000887)1.90985688
114Aplasia of the musculature (HP:0100854)1.90561036
115Short nail (HP:0001799)1.88670401
116Abnormality of the corticospinal tract (HP:0002492)1.88358206
117Duplication of thumb phalanx (HP:0009942)1.87885008
118Short clavicles (HP:0000894)1.87724826
119Optic nerve hypoplasia (HP:0000609)1.87624355
120Biconcave vertebral bodies (HP:0004586)1.86795605
121Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.86756455
122Vascular tortuosity (HP:0004948)1.86527876
123Myelomeningocele (HP:0002475)1.86476397
124Anomalous pulmonary venous return (HP:0010772)1.86388700
125Occipital encephalocele (HP:0002085)1.85967003
126Broad metatarsal (HP:0001783)1.85684422
127Abnormality of the pulmonary veins (HP:0011718)1.85424386
128Split foot (HP:0001839)1.85345672
129Cutaneous finger syndactyly (HP:0010554)1.85166290
130Preauricular pit (HP:0004467)1.85015409
131Periauricular skin pits (HP:0100277)1.85015409
132Abnormality of the nasal septum (HP:0000419)1.84369960
133Infantile muscular hypotonia (HP:0008947)1.84098011
134Hypokalemic alkalosis (HP:0001949)1.84088880
135Abnormality of the distal phalanx of the thumb (HP:0009617)1.83905599
136Syringomyelia (HP:0003396)1.83568017
137Spinal cord lesions (HP:0100561)1.83568017
138Atelectasis (HP:0100750)1.82084512
139Trigonocephaly (HP:0000243)1.81732351
140Metaphyseal dysplasia (HP:0100255)1.80016170
141Congenital ichthyosiform erythroderma (HP:0007431)1.79131924
142Hypoplastic left heart (HP:0004383)1.78449134
143Recurrent corneal erosions (HP:0000495)1.78004511
144Hypoplasia of the maxilla (HP:0000327)1.77036337
145Atrophic scars (HP:0001075)1.76566429
146Long toe (HP:0010511)1.76169176
147Pulmonary artery stenosis (HP:0004415)1.76090942
148Cutaneous syndactyly (HP:0012725)1.76080594
149Broad long bones (HP:0005622)1.75819178
150Aplasia/Hypoplasia of the hallux (HP:0008362)1.75543219
151Bifid scrotum (HP:0000048)1.75385950
152Abnormality of secondary sexual hair (HP:0009888)1.74923674
153Abnormality of the axillary hair (HP:0100134)1.74923674
154Delayed cranial suture closure (HP:0000270)1.74719710
155Fibular aplasia (HP:0002990)1.74491025
156Femoral bowing (HP:0002980)1.74378940
157Short middle phalanx of the 5th finger (HP:0004220)1.74055830
158Dislocated radial head (HP:0003083)1.73876041
159Neonatal respiratory distress (HP:0002643)1.73350025
160Prolonged QT interval (HP:0001657)1.72724537
161Abnormality of incisor morphology (HP:0011063)1.71790628
162Abnormally folded helix (HP:0008544)1.70809413
163Osteoarthritis (HP:0002758)1.69704966
164Venous insufficiency (HP:0005293)1.69161910
165Abnormality of the peritoneum (HP:0002585)1.67649562
166Neonatal short-limb short stature (HP:0008921)1.66822494
167Broad phalanx (HP:0006009)1.66409151
168Aplasia/Hypoplasia of the patella (HP:0006498)1.65777896
169Patellar aplasia (HP:0006443)1.65678749
170Exostoses (HP:0100777)1.64550633
171Arachnodactyly (HP:0001166)1.64405398
172Ulnar bowing (HP:0003031)1.64154257
173Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.60204195
174Rocker bottom foot (HP:0001838)1.59533365

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.03268479
2CASK4.28284540
3OXSR13.70928008
4LATS13.36032737
5BLK3.18758422
6WNK42.85963526
7ERBB32.80932842
8PDGFRA2.58100488
9PKN12.46513004
10STK38L2.40353311
11EPHB22.35410515
12EPHB12.14885519
13TRIB32.13550661
14PBK2.01353479
15MOS1.99012878
16STK241.91811740
17TNIK1.83267961
18LATS21.83049087
19MKNK21.82585027
20TAF11.80880212
21PASK1.76799521
22MAP3K101.71393565
23NEK61.68318282
24RET1.67428819
25MAPKAPK51.66931286
26BMPR1B1.59684219
27PTK21.57012945
28BCR1.53273783
29DDR21.52024662
30WNK11.51883250
31PNCK1.51134183
32MKNK11.50921146
33TIE11.49002720
34INSRR1.41080662
35MET1.38505431
36MAPK71.36862170
37FGFR21.35256990
38FLT31.31986350
39ROCK21.28062952
40STK31.26707490
41CDK191.25774383
42PIK3CA1.25072297
43CLK11.23902142
44FGR1.21129385
45CAMK2B1.19230593
46LRRK21.18647151
47CSNK1A1L1.18287855
48IRAK21.15926854
49CAMK1G1.15768442
50MAPK151.15377953
51PAK31.11384957
52MST41.09151593
53NTRK11.03882126
54EEF2K1.02867461
55FER0.99883435
56LIMK10.98945657
57GRK10.98664418
58PRKCE0.97799584
59ADRBK20.97510853
60IRAK10.96666520
61RIPK10.95895253
62TGFBR10.94880485
63EPHA40.94810925
64CSNK1G10.93324487
65CSNK1G30.93135237
66PAK20.92446582
67UHMK10.92225638
68EPHA30.89781009
69NEK90.89610719
70MAPK130.89340529
71RPS6KC10.89137763
72RPS6KL10.89137763
73STK160.87861408
74FGFR10.86101162
75FGFR40.84209537
76DYRK20.84208119
77DMPK0.84021455
78FES0.83786646
79CAMK2A0.81455975
80PAK60.80973944
81CAMK2D0.79823438
82GRK70.78911929
83DYRK1B0.78257762
84RPS6KA60.76288510
85MAP2K40.74134216
86CDK30.70895958
87CSNK1G20.69124152
88MUSK0.68727360
89DYRK30.68055772
90CAMK1D0.67132032
91MARK20.66670092
92MARK10.65731975
93TGFBR20.65727190
94PRKD10.65473181
95PRKCQ0.64744173
96MTOR0.62393095
97TRPM70.62271101
98MAP3K60.61568734
99ROCK10.60580782
100PRKG10.59467241
101YES10.59275685
102PTK2B0.59187792
103PIK3CG0.59021304
104ADRBK10.58751190
105PLK20.58044951
106PRPF4B0.56783108
107FYN0.55769190
108CAMK2G0.55317519
109PRKD20.55281433
110NLK0.53205808
111MAP3K130.52286097
112MAP3K120.51694111
113BMPR20.50979126
114NTRK30.50156620
115MAP3K40.49187204
116ILK0.47838415
117NTRK20.47716311
118CDK140.47388083
119PHKG20.46304544
120PHKG10.46304544
121GSK3A0.45028896
122MAPK120.44842313
123DYRK1A0.44504191
124CDK50.44371085
125NUAK10.44204986
126PLK40.44002044
127MAP3K70.43509151
128INSR0.42324202
129PKN20.42184463
130RPS6KA40.42124126
131SMG10.41806538
132WNK30.41497401
133TYRO30.41219892
134BRD40.39672836
135ERBB40.39430801
136VRK20.39117651
137MAP2K30.38676919
138SGK4940.37933634
139SGK2230.37933634
140CDK11A0.37616651
141RPS6KA50.37425262
142PRKACA0.37413903
143CDK150.37360808
144WEE10.36675423
145PDGFRB0.35985724
146STK380.35699046
147CDK60.34819997
148SIK10.32842941
149FGFR30.32257460
150CDK180.27900404
151AKT30.27584531
152PRKCH0.23674197
153SRC0.18873234
154CDK40.18796649
155CDK80.16986955
156CAMK10.16844722

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.05537209
2Axon guidance_Homo sapiens_hsa043602.54593928
3AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.53311352
4Steroid biosynthesis_Homo sapiens_hsa001002.49782532
5Fatty acid elongation_Homo sapiens_hsa000622.40569482
6Ether lipid metabolism_Homo sapiens_hsa005652.32834259
7Ribosome_Homo sapiens_hsa030102.31453962
8ECM-receptor interaction_Homo sapiens_hsa045122.21639558
9Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.14640237
10Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.99644808
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95016834
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.89504873
13MicroRNAs in cancer_Homo sapiens_hsa052061.80808036
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77610745
15Sphingolipid metabolism_Homo sapiens_hsa006001.74938622
16Thyroid cancer_Homo sapiens_hsa052161.72844678
17Colorectal cancer_Homo sapiens_hsa052101.72742963
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.67447874
19Nicotine addiction_Homo sapiens_hsa050331.66900141
20Small cell lung cancer_Homo sapiens_hsa052221.63732800
21Serotonergic synapse_Homo sapiens_hsa047261.61951689
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60674920
23Phototransduction_Homo sapiens_hsa047441.57825197
24Basal cell carcinoma_Homo sapiens_hsa052171.57287187
25Hedgehog signaling pathway_Homo sapiens_hsa043401.55916344
26Notch signaling pathway_Homo sapiens_hsa043301.53819741
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53720422
28Protein export_Homo sapiens_hsa030601.53410460
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49289047
30Chronic myeloid leukemia_Homo sapiens_hsa052201.45650253
31Glutamatergic synapse_Homo sapiens_hsa047241.44813987
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38442949
33Oxidative phosphorylation_Homo sapiens_hsa001901.37640992
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34219365
35Morphine addiction_Homo sapiens_hsa050321.32572910
36Linoleic acid metabolism_Homo sapiens_hsa005911.31092609
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30450460
38Arachidonic acid metabolism_Homo sapiens_hsa005901.29601295
39GABAergic synapse_Homo sapiens_hsa047271.28552661
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28354447
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.17311336
42Ras signaling pathway_Homo sapiens_hsa040141.14845637
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12545456
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.10760787
45Long-term depression_Homo sapiens_hsa047301.09235281
46Selenocompound metabolism_Homo sapiens_hsa004501.09192441
47Focal adhesion_Homo sapiens_hsa045101.07791195
48Protein digestion and absorption_Homo sapiens_hsa049741.07273785
49Dilated cardiomyopathy_Homo sapiens_hsa054141.06738233
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05952647
51Glioma_Homo sapiens_hsa052141.05732849
52Malaria_Homo sapiens_hsa051441.04289653
53Histidine metabolism_Homo sapiens_hsa003401.02577066
54Rheumatoid arthritis_Homo sapiens_hsa053231.02524905
55* Wnt signaling pathway_Homo sapiens_hsa043101.02305650
56Taste transduction_Homo sapiens_hsa047421.02094788
57Salivary secretion_Homo sapiens_hsa049701.01366008
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00601409
59Melanoma_Homo sapiens_hsa052180.96668588
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95993404
61Alzheimers disease_Homo sapiens_hsa050100.95704832
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94583611
63Pancreatic cancer_Homo sapiens_hsa052120.93630928
64PI3K-Akt signaling pathway_Homo sapiens_hsa041510.92075235
65Melanogenesis_Homo sapiens_hsa049160.91184230
66Tight junction_Homo sapiens_hsa045300.91148984
67Cocaine addiction_Homo sapiens_hsa050300.90134843
68Rap1 signaling pathway_Homo sapiens_hsa040150.88082779
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88042237
70Ovarian steroidogenesis_Homo sapiens_hsa049130.87357077
71Renin secretion_Homo sapiens_hsa049240.86471761
72Mineral absorption_Homo sapiens_hsa049780.86260746
73Renal cell carcinoma_Homo sapiens_hsa052110.85376364
74Autoimmune thyroid disease_Homo sapiens_hsa053200.85073381
75Gastric acid secretion_Homo sapiens_hsa049710.82348691
76HTLV-I infection_Homo sapiens_hsa051660.81627129
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81288641
78Phagosome_Homo sapiens_hsa041450.80496394
79Circadian entrainment_Homo sapiens_hsa047130.80369564
80Amphetamine addiction_Homo sapiens_hsa050310.79614733
81Calcium signaling pathway_Homo sapiens_hsa040200.79095216
82Hippo signaling pathway_Homo sapiens_hsa043900.77636675
83Other glycan degradation_Homo sapiens_hsa005110.77224812
84Huntingtons disease_Homo sapiens_hsa050160.76769725
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.76635502
86TGF-beta signaling pathway_Homo sapiens_hsa043500.75149758
87Estrogen signaling pathway_Homo sapiens_hsa049150.75148857
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74974034
89Cardiac muscle contraction_Homo sapiens_hsa042600.73154972
90Arginine and proline metabolism_Homo sapiens_hsa003300.70729633
91Gap junction_Homo sapiens_hsa045400.69443633
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69020495
93Collecting duct acid secretion_Homo sapiens_hsa049660.68649406
94Parkinsons disease_Homo sapiens_hsa050120.68217782
95Endometrial cancer_Homo sapiens_hsa052130.67298160
96Pancreatic secretion_Homo sapiens_hsa049720.66836126
97Vibrio cholerae infection_Homo sapiens_hsa051100.66002071
98GnRH signaling pathway_Homo sapiens_hsa049120.64788926
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64387917
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.63773301
101cAMP signaling pathway_Homo sapiens_hsa040240.62920876
102Amoebiasis_Homo sapiens_hsa051460.62542324
103Pathways in cancer_Homo sapiens_hsa052000.62097185
104Cholinergic synapse_Homo sapiens_hsa047250.61771835
105Sulfur metabolism_Homo sapiens_hsa009200.61411994
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61278649
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60780852
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.60136521
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.59304975
110Oxytocin signaling pathway_Homo sapiens_hsa049210.59156327
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57573981
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57000686
113Retinol metabolism_Homo sapiens_hsa008300.55151833
114Choline metabolism in cancer_Homo sapiens_hsa052310.55009448
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54896918
116Prion diseases_Homo sapiens_hsa050200.54703698
117ErbB signaling pathway_Homo sapiens_hsa040120.53871631
118MAPK signaling pathway_Homo sapiens_hsa040100.53703899
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.53266419
120Dorso-ventral axis formation_Homo sapiens_hsa043200.52672222
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.52321504
122Vitamin digestion and absorption_Homo sapiens_hsa049770.52031276
123Prostate cancer_Homo sapiens_hsa052150.51049691
124FoxO signaling pathway_Homo sapiens_hsa040680.50623108
125Proteoglycans in cancer_Homo sapiens_hsa052050.50229578
126Glucagon signaling pathway_Homo sapiens_hsa049220.49687742
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49022110
128African trypanosomiasis_Homo sapiens_hsa051430.48358195
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46783158
130Dopaminergic synapse_Homo sapiens_hsa047280.46617117
131Renin-angiotensin system_Homo sapiens_hsa046140.46495747
132Lysine degradation_Homo sapiens_hsa003100.46427988
133Hepatitis B_Homo sapiens_hsa051610.46172762
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.43621623
135Non-small cell lung cancer_Homo sapiens_hsa052230.43154760
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41425477
137Type II diabetes mellitus_Homo sapiens_hsa049300.40859612
138Prolactin signaling pathway_Homo sapiens_hsa049170.34951491
139Bladder cancer_Homo sapiens_hsa052190.34377243
140Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33112829
141Long-term potentiation_Homo sapiens_hsa047200.33102199
142ABC transporters_Homo sapiens_hsa020100.32886042
143Insulin signaling pathway_Homo sapiens_hsa049100.32762981
144Insulin secretion_Homo sapiens_hsa049110.31998700
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30972417

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