DKK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.48779123
2synaptic vesicle docking involved in exocytosis (GO:0016081)5.26527894
3glutamate secretion (GO:0014047)5.22057272
4synaptic vesicle maturation (GO:0016188)5.11947613
5locomotory exploration behavior (GO:0035641)4.98014928
6synaptic vesicle exocytosis (GO:0016079)4.97166136
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.77182531
8vocalization behavior (GO:0071625)4.62099995
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.61018487
10protein localization to synapse (GO:0035418)4.44562342
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.39022897
12regulation of synaptic vesicle exocytosis (GO:2000300)4.33668026
13regulation of glutamate receptor signaling pathway (GO:1900449)4.09333322
14exploration behavior (GO:0035640)3.95148643
15layer formation in cerebral cortex (GO:0021819)3.92692571
16ionotropic glutamate receptor signaling pathway (GO:0035235)3.89821573
17innervation (GO:0060384)3.88269492
18regulation of neuronal synaptic plasticity (GO:0048168)3.87639234
19regulation of synaptic vesicle transport (GO:1902803)3.87373613
20neuronal action potential propagation (GO:0019227)3.85804258
21cellular potassium ion homeostasis (GO:0030007)3.85601982
22proline transport (GO:0015824)3.75004707
23regulation of long-term neuronal synaptic plasticity (GO:0048169)3.69300337
24glutamate receptor signaling pathway (GO:0007215)3.66924510
25neuron cell-cell adhesion (GO:0007158)3.66697122
26neurotransmitter secretion (GO:0007269)3.65585140
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.63667977
28long-term synaptic potentiation (GO:0060291)3.62535591
29synaptic transmission, glutamatergic (GO:0035249)3.58725305
30sodium ion export (GO:0071436)3.54941492
31regulation of excitatory postsynaptic membrane potential (GO:0060079)3.49854049
32dendritic spine morphogenesis (GO:0060997)3.49733985
33protein heterotrimerization (GO:0070208)3.48427169
34neurotransmitter-gated ion channel clustering (GO:0072578)3.46451809
35cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.39291195
36extracellular matrix assembly (GO:0085029)3.37492583
37regulation of synaptic plasticity (GO:0048167)3.37271946
38cell communication by electrical coupling (GO:0010644)3.36574741
39neuron-neuron synaptic transmission (GO:0007270)3.35927584
40regulation of postsynaptic membrane potential (GO:0060078)3.35577072
41positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.31838323
42synaptic vesicle endocytosis (GO:0048488)3.31085926
43negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.31052875
44long-term memory (GO:0007616)3.30815169
45axonal fasciculation (GO:0007413)3.26774848
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.25793664
47neuron recognition (GO:0008038)3.25187736
48regulation of synapse structural plasticity (GO:0051823)3.22579889
49regulation of dendritic spine morphogenesis (GO:0061001)3.22548304
50endodermal cell differentiation (GO:0035987)3.18371891
51positive regulation of neurotransmitter secretion (GO:0001956)3.17309964
52cerebellar granule cell differentiation (GO:0021707)3.14266169
53positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.14069211
54regulation of neurotransmitter secretion (GO:0046928)3.13752507
55cytoskeletal anchoring at plasma membrane (GO:0007016)3.08306506
56positive regulation of synapse maturation (GO:0090129)3.07041418
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.06318772
58positive regulation of membrane potential (GO:0045838)3.05030481
59response to histamine (GO:0034776)3.04597611
60G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.03085792
61neurotransmitter transport (GO:0006836)3.02424132
62collagen fibril organization (GO:0030199)3.00531984
63bone trabecula formation (GO:0060346)2.99759066
64response to auditory stimulus (GO:0010996)2.99517952
65positive regulation of neurotransmitter transport (GO:0051590)2.99107882
66regulation of synaptic transmission, glutamatergic (GO:0051966)2.99090902
67regulation of vesicle fusion (GO:0031338)2.98524219
68behavioral defense response (GO:0002209)2.97700538
69behavioral fear response (GO:0001662)2.97700538
70amino acid import (GO:0043090)2.97683690
71regulation of voltage-gated calcium channel activity (GO:1901385)2.96604826
72dendritic spine organization (GO:0097061)2.96320874
73activation of protein kinase A activity (GO:0034199)2.96122805
74G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.94013534
75skin morphogenesis (GO:0043589)2.93898474
76fear response (GO:0042596)2.93140600
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.92828784
78negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91514645
79regulation of neurotransmitter transport (GO:0051588)2.90982574
80L-amino acid import (GO:0043092)2.90975901
81glial cell proliferation (GO:0014009)2.87984085
82regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.87449220
83adhesion of symbiont to host cell (GO:0044650)2.87128845
84virion attachment to host cell (GO:0019062)2.87128845
85auditory behavior (GO:0031223)2.86782564
86cell adhesion mediated by integrin (GO:0033627)2.85258245
87positive regulation of synaptic transmission (GO:0050806)2.83880247
88regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.82710106
89regulation of dendritic spine development (GO:0060998)2.82706377
90cell migration involved in heart development (GO:0060973)2.80863901
91chondrocyte proliferation (GO:0035988)2.79733207
92chemosensory behavior (GO:0007635)2.77317549
93gamma-aminobutyric acid signaling pathway (GO:0007214)2.76584836
94postsynaptic membrane organization (GO:0001941)2.76008874
95cellular sodium ion homeostasis (GO:0006883)2.75873321
96regulation of neurotransmitter levels (GO:0001505)2.74694538
97membrane depolarization (GO:0051899)2.72233427
98presynaptic membrane assembly (GO:0097105)2.71472293
99type B pancreatic cell proliferation (GO:0044342)2.71372091
100neuromuscular process controlling balance (GO:0050885)2.71338092
101potassium ion homeostasis (GO:0055075)2.70778334
102endocardial cushion development (GO:0003197)2.70041566
103regulation of synaptic transmission (GO:0050804)2.69933478
104suckling behavior (GO:0001967)2.66874213
105sequestering of extracellular ligand from receptor (GO:0035581)2.66573622
106transmission of nerve impulse (GO:0019226)2.65967773
107neuronal ion channel clustering (GO:0045161)2.64747368
108positive regulation of axon extension (GO:0045773)2.64454311
109axon extension (GO:0048675)2.64295444
110cell communication involved in cardiac conduction (GO:0086065)2.64124487
111positive regulation of fibroblast migration (GO:0010763)2.64058632
112vesicle transport along microtubule (GO:0047496)2.64024867
113positive regulation of dendritic spine development (GO:0060999)2.63538532
114positive regulation of vesicle fusion (GO:0031340)2.63480792
115learning (GO:0007612)2.63164311
116dendrite morphogenesis (GO:0048813)2.63105560
117positive regulation of potassium ion transmembrane transport (GO:1901381)2.61919394
118positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.60979530
119gamma-aminobutyric acid transport (GO:0015812)2.60521591
120startle response (GO:0001964)2.59305068
121alanine transport (GO:0032328)2.59226049
122kidney mesenchyme development (GO:0072074)2.58918128
123regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.58850504
124membrane depolarization during action potential (GO:0086010)2.58562567
125regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.57927301
126synapse organization (GO:0050808)2.57870134
127hemidesmosome assembly (GO:0031581)2.56815361
128peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.53671984
129protein targeting to plasma membrane (GO:0072661)2.53455113
130cell-substrate junction assembly (GO:0007044)2.51009869
131positive regulation of synapse assembly (GO:0051965)2.46244863
132neuron projection extension (GO:1990138)2.42724088
133adhesion of symbiont to host (GO:0044406)2.42472012
134regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.42278631
135mating behavior (GO:0007617)2.42164187
136regulation of axon extension involved in axon guidance (GO:0048841)2.40477563
137response to gravity (GO:0009629)2.39130948
138detection of calcium ion (GO:0005513)2.38385431
139dermatan sulfate biosynthetic process (GO:0030208)2.33724662
140protein retention in ER lumen (GO:0006621)2.32127913
141dermatan sulfate metabolic process (GO:0030205)2.29116348
142collagen metabolic process (GO:0032963)2.28646186
143chondroitin sulfate catabolic process (GO:0030207)2.28017071
144protein localization to endosome (GO:0036010)2.27666796
145cellular response to vitamin (GO:0071295)2.25218556
146astrocyte development (GO:0014002)2.24674828
147regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.24472901
148metanephric mesenchyme development (GO:0072075)2.23841408
149adherens junction assembly (GO:0034333)2.23479538
150cerebellar Purkinje cell layer development (GO:0021680)2.23472097
151cellular response to catecholamine stimulus (GO:0071870)2.23051541
152cellular response to monoamine stimulus (GO:0071868)2.23051541
153extracellular fibril organization (GO:0043206)2.22722336
154planar cell polarity pathway involved in neural tube closure (GO:0090179)2.22423808
155regulation of the force of heart contraction (GO:0002026)2.22056311

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.39097781
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19994100
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.17352516
4GBX2_23144817_ChIP-Seq_PC3_Human3.16364553
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.11833003
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01083061
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.89549263
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.89549263
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.86018293
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.82122140
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72488145
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.68160418
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.63360972
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56248553
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.44793047
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43045157
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.41360287
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.24992472
19DROSHA_22980978_ChIP-Seq_HELA_Human2.23913204
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.23798096
21REST_21632747_ChIP-Seq_MESCs_Mouse2.18873429
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.14786378
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14072755
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.12556196
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.10751412
26AR_21572438_ChIP-Seq_LNCaP_Human1.93600772
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.80883176
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.72458038
29RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.68496708
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66431311
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65976403
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65055079
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.60995022
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.57364298
35SMAD4_21799915_ChIP-Seq_A2780_Human1.56872130
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56530946
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56500178
38* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.51943612
39* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49276826
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48035474
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44318373
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.42493286
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.41592457
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38572366
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37220541
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.36704990
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35617820
48* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35249391
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35135203
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32984860
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.32911794
52P300_19829295_ChIP-Seq_ESCs_Human1.32157941
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.31679831
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31220299
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28215513
56AR_25329375_ChIP-Seq_VCAP_Human1.26269496
57CLOCK_20551151_ChIP-Seq_293T_Human1.25727415
58TET1_21490601_ChIP-Seq_MESCs_Mouse1.25621713
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25081637
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.24052508
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22160342
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22155205
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22041788
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21770934
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.21377715
66CJUN_26792858_Chip-Seq_BT549_Human1.20800335
67ZNF274_21170338_ChIP-Seq_K562_Hela1.19536443
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18363103
69TP53_23651856_ChIP-Seq_MEFs_Mouse1.17964096
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.17823262
71* AR_19668381_ChIP-Seq_PC3_Human1.17417554
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16886684
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.15853229
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.14942316
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14090586
76TP53_18474530_ChIP-ChIP_U2OS_Human1.13853045
77OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13213518
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11930732
79* TP53_16413492_ChIP-PET_HCT116_Human1.11727392
80TP53_20018659_ChIP-ChIP_R1E_Mouse1.10058736
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.10031605
82* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09424878
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07918504
84TAF15_26573619_Chip-Seq_HEK293_Human1.07758273
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07251831
86* BRD4_25478319_ChIP-Seq_HGPS_Human1.07194976
87ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06922089
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06851205
89DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06004218
90CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05428619
91AHR_22903824_ChIP-Seq_MCF-7_Human1.04990387
92TBX20_22080862_ChIP-Seq_HEART_Mouse1.04942650
93TBX20_22328084_ChIP-Seq_HEART_Mouse1.04942650
94BCAT_22108803_ChIP-Seq_LS180_Human1.04718278
95ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04640233
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04315930
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03741706
98* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03458899
99P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03414280
100DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03411875
101SMAD3_21741376_ChIP-Seq_HESCs_Human1.02534709
102* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01834600
103KDM2B_26808549_Chip-Seq_K562_Human0.99987565
104SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99283673
105* STAT3_23295773_ChIP-Seq_U87_Human0.99116722
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99017944
107ISL1_27105846_Chip-Seq_CPCs_Mouse0.98492378
108YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97057947
109RXR_22108803_ChIP-Seq_LS180_Human0.96829131
110PRDM14_20953172_ChIP-Seq_ESCs_Human0.96666653
111LXR_22292898_ChIP-Seq_THP-1_Human0.96591372
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.96498522
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96410006
114THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96320720
115* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96180654
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95721437
117GATA2_21666600_ChIP-Seq_HMVEC_Human0.94541143
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93505425
119NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93505425
120TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93238638
121* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93208413
122* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92546196
123CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92207942
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91814534
125* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91479351
126BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91217574
127TCF4_23295773_ChIP-Seq_U87_Human0.91010900
128TP53_22127205_ChIP-Seq_IMR90_Human0.90587895
129POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90299816
130JUN_21703547_ChIP-Seq_K562_Human0.90297236
131ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90240242
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89773277
133SMAD3_21741376_ChIP-Seq_ESCs_Human0.89725281
134* CTCF_27219007_Chip-Seq_Bcells_Human0.89712806
135SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89272197
136ELK3_25401928_ChIP-Seq_HUVEC_Human0.87553028
137SA1_22415368_ChIP-Seq_MEFs_Mouse0.87210996
138* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.84654363
139SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.83022733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.38968966
2MP0003880_abnormal_central_pattern4.33435013
3MP0003635_abnormal_synaptic_transmissio3.70646450
4MP0004270_analgesia3.35849840
5MP0002063_abnormal_learning/memory/cond3.00583917
6MP0009745_abnormal_behavioral_response2.88837400
7MP0001968_abnormal_touch/_nociception2.73839735
8MP0002064_seizures2.72092052
9MP0004858_abnormal_nervous_system2.67282967
10MP0004272_abnormal_basement_membrane2.61112556
11MP0002572_abnormal_emotion/affect_behav2.42515826
12MP0002736_abnormal_nociception_after2.34359471
13MP0009780_abnormal_chondrocyte_physiolo2.30104006
14MP0003329_amyloid_beta_deposits2.26833132
15MP0002734_abnormal_mechanical_nocicepti2.23078885
16MP0001486_abnormal_startle_reflex2.18501555
17MP0009046_muscle_twitch2.14463573
18MP0002272_abnormal_nervous_system2.07289254
19MP0005551_abnormal_eye_electrophysiolog2.04777348
20MP0010368_abnormal_lymphatic_system2.04557842
21MP0001501_abnormal_sleep_pattern2.02674772
22MP0002822_catalepsy1.98790982
23MP0001440_abnormal_grooming_behavior1.96056061
24MP0003566_abnormal_cell_adhesion1.85811121
25MP0005423_abnormal_somatic_nervous1.76569239
26MP0002735_abnormal_chemical_nociception1.75026783
27MP0001542_abnormal_bone_strength1.73487658
28MP0000778_abnormal_nervous_system1.69719397
29MP0001502_abnormal_circadian_rhythm1.66023739
30MP0008569_lethality_at_weaning1.65867875
31MP0001970_abnormal_pain_threshold1.59354301
32MP0002067_abnormal_sensory_capabilities1.58983499
33MP0002184_abnormal_innervation1.57093178
34MP0002733_abnormal_thermal_nociception1.56323202
35MP0003011_delayed_dark_adaptation1.55684218
36MP0002295_abnormal_pulmonary_circulatio1.53409173
37MP0002090_abnormal_vision1.50316150
38MP0000751_myopathy1.50254089
39MP0004084_abnormal_cardiac_muscle1.48615319
40MP0004811_abnormal_neuron_physiology1.47164432
41MP0008438_abnormal_cutaneous_collagen1.46244820
42MP0005253_abnormal_eye_physiology1.44685362
43MP0003091_abnormal_cell_migration1.44113296
44MP0002557_abnormal_social/conspecific_i1.41230195
45MP0002882_abnormal_neuron_morphology1.40812536
46MP0002909_abnormal_adrenal_gland1.38967711
47MP0005508_abnormal_skeleton_morphology1.35064968
48MP0005623_abnormal_meninges_morphology1.34497858
49MP0000767_abnormal_smooth_muscle1.34030894
50MP0005646_abnormal_pituitary_gland1.32228473
51MP0000955_abnormal_spinal_cord1.30070761
52MP0002638_abnormal_pupillary_reflex1.29889081
53MP0004885_abnormal_endolymph1.29750714
54MP0004924_abnormal_behavior1.26405929
55MP0005386_behavior/neurological_phenoty1.26405929
56MP0002896_abnormal_bone_mineralization1.23909900
57MP0005503_abnormal_tendon_morphology1.23659078
58MP0006072_abnormal_retinal_apoptosis1.23262873
59MP0002837_dystrophic_cardiac_calcinosis1.23238308
60MP0003633_abnormal_nervous_system1.22683377
61MP0001348_abnormal_lacrimal_gland1.22683241
62MP0001984_abnormal_olfaction1.18698222
63MP0006276_abnormal_autonomic_nervous1.18119777
64MP0010386_abnormal_urinary_bladder1.17057020
65MP0000920_abnormal_myelination1.15363970
66MP0004036_abnormal_muscle_relaxation1.14302608
67MP0001905_abnormal_dopamine_level1.13267153
68MP0003879_abnormal_hair_cell1.13061625
69* MP0002066_abnormal_motor_capabilities/c1.11054795
70MP0003283_abnormal_digestive_organ1.09792248
71MP0003075_altered_response_to1.09460503
72MP0005023_abnormal_wound_healing1.09278735
73MP0003279_aneurysm1.08717861
74MP0004510_myositis1.07439753
75MP0004233_abnormal_muscle_weight1.06438633
76MP0003631_nervous_system_phenotype1.05944222
77MP0005275_abnormal_skin_tensile1.04826779
78MP0001177_atelectasis1.03257401
79MP0000013_abnormal_adipose_tissue1.02341531
80MP0000604_amyloidosis1.00249644
81MP0000749_muscle_degeneration0.99152971
82MP0009250_abnormal_appendicular_skeleto0.98414346
83MP0005409_darkened_coat_color0.97187060
84MP0002152_abnormal_brain_morphology0.95675954
85MP0000579_abnormal_nail_morphology0.95603532
86MP0003634_abnormal_glial_cell0.95091656
87MP0003122_maternal_imprinting0.94920915
88MP0003385_abnormal_body_wall0.94129411
89MP0000762_abnormal_tongue_morphology0.92730943
90MP0005171_absent_coat_pigmentation0.92264062
91MP0002060_abnormal_skin_morphology0.91107234
92MP0004484_altered_response_of0.91077538
93MP0004215_abnormal_myocardial_fiber0.89710686
94MP0002752_abnormal_somatic_nervous0.89375003
95MP0006054_spinal_hemorrhage0.88940921
96MP0001849_ear_inflammation0.87911242
97MP0002229_neurodegeneration0.87799737
98MP0003950_abnormal_plasma_membrane0.85225964
99MP0005195_abnormal_posterior_eye0.85000543
100MP0003941_abnormal_skin_development0.83913808
101MP0006138_congestive_heart_failure0.83647108
102MP0001958_emphysema0.83283758
103MP0005388_respiratory_system_phenotype0.82581893
104MP0002133_abnormal_respiratory_system0.82581893
105MP0004145_abnormal_muscle_electrophysio0.82355932
106MP0003705_abnormal_hypodermis_morpholog0.82332197
107MP0001879_abnormal_lymphatic_vessel0.81297877
108MP0003632_abnormal_nervous_system0.81125900
109MP0001299_abnormal_eye_distance/0.79923167
110MP0000759_abnormal_skeletal_muscle0.79384645
111MP0003942_abnormal_urinary_system0.79346257
112MP0002972_abnormal_cardiac_muscle0.79209340
113MP0004085_abnormal_heartbeat0.77984051
114MP0010234_abnormal_vibrissa_follicle0.77359568
115MP0003137_abnormal_impulse_conducting0.77350728
116MP0002653_abnormal_ependyma_morphology0.77113266
117MP0003787_abnormal_imprinting0.76305900
118MP0000428_abnormal_craniofacial_morphol0.75880552
119MP0005595_abnormal_vascular_smooth0.75746075
120MP0010030_abnormal_orbit_morphology0.75609014
121MP0009384_cardiac_valve_regurgitation0.73949788
122MP0004087_abnormal_muscle_fiber0.73540789
123MP0005645_abnormal_hypothalamus_physiol0.72090583
124MP0003690_abnormal_glial_cell0.71545236
125MP0002069_abnormal_eating/drinking_beha0.71431484
126MP0001963_abnormal_hearing_physiology0.71143666
127MP0005187_abnormal_penis_morphology0.71054133
128MP0000534_abnormal_ureter_morphology0.70227382
129MP0000733_abnormal_muscle_development0.70112190
130MP0008872_abnormal_physiological_respon0.69994520
131MP0008874_decreased_physiological_sensi0.69922420
132MP0005167_abnormal_blood-brain_barrier0.69483155
133MP0005257_abnormal_intraocular_pressure0.68078037
134MP0002108_abnormal_muscle_morphology0.67572059
135MP0005394_taste/olfaction_phenotype0.66822453
136MP0005499_abnormal_olfactory_system0.66822453
137MP0005620_abnormal_muscle_contractility0.66641360
138MP0001664_abnormal_digestion0.60596108
139MP0004130_abnormal_muscle_cell0.60106663

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.42057459
2Myokymia (HP:0002411)5.58954957
3Focal seizures (HP:0007359)4.78485759
4Epileptic encephalopathy (HP:0200134)4.31388204
5Visual hallucinations (HP:0002367)4.24654698
6Aortic dissection (HP:0002647)4.00003006
7Aortic aneurysm (HP:0004942)3.97265842
8Atonic seizures (HP:0010819)3.90608163
9Atrophic scars (HP:0001075)3.86060191
10Amblyopia (HP:0000646)3.82704931
11Ankle contracture (HP:0006466)3.69324596
12Megalencephaly (HP:0001355)3.66315211
13Nuclear cataract (HP:0100018)3.48527518
14Type 1 muscle fiber predominance (HP:0003803)3.46216005
15Febrile seizures (HP:0002373)3.36989835
16Absence seizures (HP:0002121)3.36895613
17Follicular hyperkeratosis (HP:0007502)3.34868549
18Action tremor (HP:0002345)3.30883907
19Progressive cerebellar ataxia (HP:0002073)3.30654736
20Wormian bones (HP:0002645)3.22966802
21Soft skin (HP:0000977)3.21830681
22Generalized tonic-clonic seizures (HP:0002069)3.13929678
23Cerebral inclusion bodies (HP:0100314)3.11958464
24Spinal rigidity (HP:0003306)3.04796657
25Dialeptic seizures (HP:0011146)3.03969460
26Supranuclear gaze palsy (HP:0000605)2.98477609
27Central scotoma (HP:0000603)2.97503710
28Hyperventilation (HP:0002883)2.91704041
29Fragile skin (HP:0001030)2.91506324
30Neurofibrillary tangles (HP:0002185)2.89194480
31Protrusio acetabuli (HP:0003179)2.83180261
32Depression (HP:0000716)2.81840253
33Zonular cataract (HP:0010920)2.79131562
34Genu recurvatum (HP:0002816)2.72594839
35Scotoma (HP:0000575)2.71599351
36Slender build (HP:0001533)2.69866284
37Increased variability in muscle fiber diameter (HP:0003557)2.66604638
38Impaired vibration sensation in the lower limbs (HP:0002166)2.65847759
39Obstructive sleep apnea (HP:0002870)2.64937150
40Cerebral aneurysm (HP:0004944)2.59425998
41Congenital stationary night blindness (HP:0007642)2.58715659
42Mildly elevated creatine phosphokinase (HP:0008180)2.57854692
43Truncal ataxia (HP:0002078)2.55555606
44Cervical subluxation (HP:0003308)2.52465104
45Mild short stature (HP:0003502)2.51344229
46Anxiety (HP:0000739)2.50992675
47Distal upper limb amyotrophy (HP:0007149)2.49779684
48Upper limb amyotrophy (HP:0009129)2.49779684
49Broad-based gait (HP:0002136)2.48331042
50Dysdiadochokinesis (HP:0002075)2.45368112
51Mitral regurgitation (HP:0001653)2.40001006
52Aplasia involving bones of the upper limbs (HP:0009823)2.39428364
53Aplasia of the phalanges of the hand (HP:0009802)2.39428364
54Aplasia involving bones of the extremities (HP:0009825)2.39428364
55Vascular tortuosity (HP:0004948)2.37005314
56Vertebral compression fractures (HP:0002953)2.35547302
57Dysmetria (HP:0001310)2.35200297
58Arterial tortuosity (HP:0005116)2.33653450
59Urinary bladder sphincter dysfunction (HP:0002839)2.30805769
60Hypoventilation (HP:0002791)2.29476395
61Hyperextensible skin (HP:0000974)2.28239434
62Mitral valve prolapse (HP:0001634)2.27676404
63Decreased electroretinogram (ERG) amplitude (HP:0000654)2.24723379
64Termporal pattern (HP:0011008)2.24199853
65Insidious onset (HP:0003587)2.24199853
66Abnormality of binocular vision (HP:0011514)2.23343743
67Diplopia (HP:0000651)2.23343743
68Bony spicule pigmentary retinopathy (HP:0007737)2.23127142
69Spondylolisthesis (HP:0003302)2.20819942
70Hemiparesis (HP:0001269)2.20513177
71Abnormal eating behavior (HP:0100738)2.18994440
72Wide anterior fontanel (HP:0000260)2.18715633
73Bradycardia (HP:0001662)2.17475226
74Poor eye contact (HP:0000817)2.17351185
75Blue sclerae (HP:0000592)2.16992084
76Postural instability (HP:0002172)2.16389864
77Coronal craniosynostosis (HP:0004440)2.16276849
78Hand muscle atrophy (HP:0009130)2.15644608
79Gaze-evoked nystagmus (HP:0000640)2.14302948
80Abnormality of skeletal muscle fiber size (HP:0012084)2.14053871
81Bundle branch block (HP:0011710)2.12354145
82Ankle clonus (HP:0011448)2.12098920
83Abnormality of macular pigmentation (HP:0008002)2.09644354
84Annular pancreas (HP:0001734)2.08585382
85Epileptiform EEG discharges (HP:0011182)2.07912913
86Peritonitis (HP:0002586)2.07525425
87Aortic regurgitation (HP:0001659)2.06871509
88Aneurysm (HP:0002617)2.05954032
89Chorioretinal atrophy (HP:0000533)2.05933118
90Joint laxity (HP:0001388)2.05681591
91Ulnar bowing (HP:0003031)2.05496025
92Atrial fibrillation (HP:0005110)2.04653650
93Shallow orbits (HP:0000586)2.04372477
94Buphthalmos (HP:0000557)2.03025403
95Biconcave vertebral bodies (HP:0004586)2.01159468
96Excessive salivation (HP:0003781)2.00728429
97Drooling (HP:0002307)2.00728429
98Abnormal social behavior (HP:0012433)1.99873471
99Impaired social interactions (HP:0000735)1.99873471
100Premature rupture of membranes (HP:0001788)1.99729485
101Torticollis (HP:0000473)1.98710709
102Overgrowth (HP:0001548)1.98393341
103Urinary urgency (HP:0000012)1.98234220
104Narrow nasal bridge (HP:0000446)1.97300994
105Stereotypic behavior (HP:0000733)1.97078023
106Turricephaly (HP:0000262)1.95038507
107Sudden death (HP:0001699)1.94688975
108Impaired smooth pursuit (HP:0007772)1.92092933
109Wrist flexion contracture (HP:0001239)1.91780002
110Choroideremia (HP:0001139)1.90566435
111Clumsiness (HP:0002312)1.90499619
112Genetic anticipation (HP:0003743)1.90092233
113Increased connective tissue (HP:0009025)1.90039628
114Abnormality of the lower motor neuron (HP:0002366)1.89525824
115Focal dystonia (HP:0004373)1.88902330
116Primary atrial arrhythmia (HP:0001692)1.88712340
117Pheochromocytoma (HP:0002666)1.86383781
118EEG with generalized epileptiform discharges (HP:0011198)1.85756726
119Craniofacial dystonia (HP:0012179)1.85455546
120Supraventricular arrhythmia (HP:0005115)1.84691903
121Elbow flexion contracture (HP:0002987)1.82205135
122Insomnia (HP:0100785)1.82147117
123Rapidly progressive (HP:0003678)1.81800679
124Broad metatarsal (HP:0001783)1.81792719
125Supraventricular tachycardia (HP:0004755)1.81375925
126Hemiplegia (HP:0002301)1.81109629
127Impaired vibratory sensation (HP:0002495)1.80136176
128Absent speech (HP:0001344)1.79778784
129Abnormal rod and cone electroretinograms (HP:0008323)1.79346926
130Bradykinesia (HP:0002067)1.79144743
131Camptodactyly of toe (HP:0001836)1.78710522
132Delusions (HP:0000746)1.77517686
133Lower limb muscle weakness (HP:0007340)1.77334098
134Status epilepticus (HP:0002133)1.76556625
135Increased corneal curvature (HP:0100692)1.76495015
136Keratoconus (HP:0000563)1.76495015
137Dysmetric saccades (HP:0000641)1.76433981
138Ventricular fibrillation (HP:0001663)1.75957205
139Mitral stenosis (HP:0001718)1.75939015
140Abnormal atrioventricular conduction (HP:0005150)1.75752969
141Distal lower limb amyotrophy (HP:0008944)1.75329448
142Long toe (HP:0010511)1.74815435
143Dilatation of the ascending aorta (HP:0005111)1.74695188
144Achilles tendon contracture (HP:0001771)1.74223709
145Lower limb amyotrophy (HP:0007210)1.73677300
146Aqueductal stenosis (HP:0002410)1.72959719
147Difficulty climbing stairs (HP:0003551)1.72858588
148Hypoplasia of the iris (HP:0007676)1.72461746
149Hypsarrhythmia (HP:0002521)1.72324845
150Limb-girdle muscle weakness (HP:0003325)1.71705455
151Incomplete penetrance (HP:0003829)1.70442964
152Abnormality of dentin (HP:0010299)1.70165249
153Hyporeflexia of lower limbs (HP:0002600)1.69914795
154Bladder diverticulum (HP:0000015)1.69295773
155Neonatal short-limb short stature (HP:0008921)1.68932897
156Spastic gait (HP:0002064)1.68925405
157Intention tremor (HP:0002080)1.67398855
158Bowel diverticulosis (HP:0005222)1.66543898
159Hyperacusis (HP:0010780)1.65568736
160Hydroureter (HP:0000072)1.65513478
161Round ear (HP:0100830)1.65423331
162Distal lower limb muscle weakness (HP:0009053)1.65257470
163Renal duplication (HP:0000075)1.63617566
164Limited hip movement (HP:0008800)1.63521900
165Papilledema (HP:0001085)1.63448215

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.48290495
2NTRK34.03783780
3MYLK3.42567072
4MAP3K93.14143424
5MAP3K42.70116737
6MINK12.51627907
7DAPK22.51260797
8PRKD32.31850921
9TTN2.26644182
10RIPK42.22678021
11MAP2K72.17266332
12NTRK12.12224799
13PLK22.04218454
14PAK62.00019195
15NTRK21.97215132
16KSR21.96464082
17LMTK21.96136850
18LIMK11.89920560
19MAP3K121.89912835
20CASK1.86070870
21EPHB21.84719219
22MAP2K41.71526468
23PAK21.70881954
24PTK2B1.65354584
25TESK11.62885080
26CAMKK11.62078128
27DAPK11.61324814
28KSR11.59335444
29GRK51.56140295
30PRPF4B1.53530938
31CDK191.43643602
32CDK51.43318602
33MARK11.39650614
34STK381.33714142
35DDR21.31762400
36ARAF1.29137398
37MOS1.26651804
38PHKG21.23280225
39PHKG11.23280225
40PRKCG1.20051161
41NEK91.17723639
42PNCK1.15056870
43CAMK2A1.11162547
44LATS21.08753786
45FGR1.05669866
46PRKD21.03611692
47GRK71.01214271
48MAP3K20.99899278
49FER0.99034101
50PAK30.99023106
51MAP3K130.97863033
52SGK2230.97238978
53SGK4940.97238978
54RET0.94823638
55TGFBR20.91911059
56SIK20.88971479
57CAMK10.86602684
58WNK10.85650921
59PDGFRB0.84905534
60CDK180.84843481
61TYRO30.84408840
62CDK150.83028951
63MET0.82941848
64BMPR20.82654297
65PRKCH0.81893156
66NEK10.79569989
67CAMK2B0.79513494
68AKT30.79512741
69TNIK0.79295914
70CDK140.79080485
71MAPK130.78479882
72SGK20.77235581
73PRKG20.76042949
74RPS6KA20.73463756
75MARK20.71531289
76RAF10.70086698
77CDK11A0.70051757
78ROCK20.68197571
79DMPK0.68162720
80SGK30.68055194
81SGK10.67830126
82DAPK30.67360291
83CAMKK20.66440127
84NME10.66145091
85PINK10.65781001
86PDGFRA0.65587841
87PRKD10.64651020
88DYRK1A0.63825939
89STK110.62821015
90ADRBK10.62570121
91FES0.62478214
92MAP2K10.61041812
93PRKCE0.59400300
94PDK10.58315058
95UHMK10.57369301
96TIE10.56685862
97PIM20.56443355
98OXSR10.56364038
99DYRK1B0.55623571
100PDK30.53589659
101PDK40.53589659
102MAP3K60.52867724
103ICK0.52561305
104ROCK10.51333201
105PDPK10.51005208
106CAMK2D0.50824677
107MAP3K70.50509041
108ABL20.49809724
109BMX0.48824898
110TRIB30.48304608
111LATS10.47336746
112FLT30.45679340
113MAPK70.44937777
114PKN10.44594540
115MAPK120.43902796
116PAK40.43894800
117CSNK1G20.43423822
118CAMK40.43343766
119EPHB10.43196245
120CDC42BPA0.41884542
121PRKCZ0.41096610
122CAMK2G0.41012796
123SRC0.40430332
124ERN10.40325012
125MAP3K10.40227845
126FYN0.40145048
127FGFR20.40113591
128MAPK40.38584097
129RIPK10.38433800
130RPS6KA30.38353924
131SIK10.37149637
132CAMK1G0.35912481
133PTK20.35779736
134MAPK100.35148405

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.09829821
2Synaptic vesicle cycle_Homo sapiens_hsa047212.91603384
3Long-term potentiation_Homo sapiens_hsa047202.57068341
4Circadian entrainment_Homo sapiens_hsa047132.56604880
5Phototransduction_Homo sapiens_hsa047442.52938821
6Olfactory transduction_Homo sapiens_hsa047402.51405084
7Amphetamine addiction_Homo sapiens_hsa050312.42575985
8Glutamatergic synapse_Homo sapiens_hsa047242.37114404
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.31369208
10Salivary secretion_Homo sapiens_hsa049702.23828090
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.19097514
12GABAergic synapse_Homo sapiens_hsa047272.17533661
13Morphine addiction_Homo sapiens_hsa050322.03595412
14Gastric acid secretion_Homo sapiens_hsa049712.00094258
15Dopaminergic synapse_Homo sapiens_hsa047281.97438770
16Insulin secretion_Homo sapiens_hsa049111.96589299
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74361955
18Cholinergic synapse_Homo sapiens_hsa047251.73841255
19Renin secretion_Homo sapiens_hsa049241.73225784
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63614928
21Oxytocin signaling pathway_Homo sapiens_hsa049211.62832275
22Calcium signaling pathway_Homo sapiens_hsa040201.57821773
23GnRH signaling pathway_Homo sapiens_hsa049121.45732152
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45358040
25Long-term depression_Homo sapiens_hsa047301.43562398
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42090493
27Serotonergic synapse_Homo sapiens_hsa047261.42027143
28Nitrogen metabolism_Homo sapiens_hsa009101.41814678
29Cocaine addiction_Homo sapiens_hsa050301.38607030
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.37525231
31Taste transduction_Homo sapiens_hsa047421.36896587
32Collecting duct acid secretion_Homo sapiens_hsa049661.32481868
33Glioma_Homo sapiens_hsa052141.30690781
34Protein digestion and absorption_Homo sapiens_hsa049741.29644625
35Melanogenesis_Homo sapiens_hsa049161.29028607
36Gap junction_Homo sapiens_hsa045401.27573540
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26865385
38cAMP signaling pathway_Homo sapiens_hsa040241.24045567
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22595768
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18609428
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15366345
42Axon guidance_Homo sapiens_hsa043601.13509106
43Estrogen signaling pathway_Homo sapiens_hsa049151.08747271
44Dilated cardiomyopathy_Homo sapiens_hsa054141.07492197
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.03946210
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.01810518
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00234170
48Cardiac muscle contraction_Homo sapiens_hsa042600.99125530
49Vibrio cholerae infection_Homo sapiens_hsa051100.94940712
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94503906
51ErbB signaling pathway_Homo sapiens_hsa040120.89978963
52Pancreatic secretion_Homo sapiens_hsa049720.84063569
53Thyroid hormone synthesis_Homo sapiens_hsa049180.83835379
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83171433
55Type II diabetes mellitus_Homo sapiens_hsa049300.80605100
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80568131
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.80136597
58Adherens junction_Homo sapiens_hsa045200.79578635
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79199349
60PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78112680
61Glucagon signaling pathway_Homo sapiens_hsa049220.77302391
62Tight junction_Homo sapiens_hsa045300.76745374
63VEGF signaling pathway_Homo sapiens_hsa043700.73772169
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69752671
65Oocyte meiosis_Homo sapiens_hsa041140.69419050
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69315989
67Wnt signaling pathway_Homo sapiens_hsa043100.68145175
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68008199
69Rap1 signaling pathway_Homo sapiens_hsa040150.67373820
70Circadian rhythm_Homo sapiens_hsa047100.66712049
71Choline metabolism in cancer_Homo sapiens_hsa052310.66593716
72Dorso-ventral axis formation_Homo sapiens_hsa043200.64952968
73Vitamin B6 metabolism_Homo sapiens_hsa007500.63425334
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61876350
75Ras signaling pathway_Homo sapiens_hsa040140.60782375
76MAPK signaling pathway_Homo sapiens_hsa040100.60287515
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.58800482
78Bladder cancer_Homo sapiens_hsa052190.56552270
79Fatty acid biosynthesis_Homo sapiens_hsa000610.56023984
80Basal cell carcinoma_Homo sapiens_hsa052170.55379972
81Bile secretion_Homo sapiens_hsa049760.52767006
82mTOR signaling pathway_Homo sapiens_hsa041500.52489464
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.52149480
84Pathways in cancer_Homo sapiens_hsa052000.52118665
85African trypanosomiasis_Homo sapiens_hsa051430.51281274
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.51184132
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50934689
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49822945
89Alcoholism_Homo sapiens_hsa050340.48040594
90Focal adhesion_Homo sapiens_hsa045100.47171904
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47124507
92MicroRNAs in cancer_Homo sapiens_hsa052060.46867421
93Chronic myeloid leukemia_Homo sapiens_hsa052200.46557328
94TGF-beta signaling pathway_Homo sapiens_hsa043500.46552640
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46400839
96Small cell lung cancer_Homo sapiens_hsa052220.45819342
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.44637369
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44457509
99Endocytosis_Homo sapiens_hsa041440.40838293
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40504425
101Alzheimers disease_Homo sapiens_hsa050100.40022857
102Renal cell carcinoma_Homo sapiens_hsa052110.38920067
103Inositol phosphate metabolism_Homo sapiens_hsa005620.38265723
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37847758
105Insulin signaling pathway_Homo sapiens_hsa049100.37388294
106ECM-receptor interaction_Homo sapiens_hsa045120.37192313
107Proteoglycans in cancer_Homo sapiens_hsa052050.36952036
108Prion diseases_Homo sapiens_hsa050200.36602856
109Endometrial cancer_Homo sapiens_hsa052130.36460890
110Non-small cell lung cancer_Homo sapiens_hsa052230.35881974
111Amoebiasis_Homo sapiens_hsa051460.34343827
112Melanoma_Homo sapiens_hsa052180.33927672
113Hippo signaling pathway_Homo sapiens_hsa043900.33258868
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32585836
115Hedgehog signaling pathway_Homo sapiens_hsa043400.31709838
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31526829
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30703600

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