DKK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration involved in gastrulation (GO:0042074)9.81185606
2negative regulation of activin receptor signaling pathway (GO:0032926)9.58813638
3endoderm formation (GO:0001706)8.90151064
4somite rostral/caudal axis specification (GO:0032525)8.06896104
5primitive streak formation (GO:0090009)7.64160446
6signal transduction involved in regulation of gene expression (GO:0023019)7.57694839
7anterior/posterior axis specification (GO:0009948)7.44103596
8regulation of activin receptor signaling pathway (GO:0032925)6.57985442
9diterpenoid biosynthetic process (GO:0016102)6.19588621
10retinal metabolic process (GO:0042574)6.14071619
11gastrulation (GO:0007369)6.00258567
12extracellular regulation of signal transduction (GO:1900115)5.91746643
13extracellular negative regulation of signal transduction (GO:1900116)5.91746643
14anterior/posterior axis specification, embryo (GO:0008595)5.67446035
15DNA replication-dependent nucleosome assembly (GO:0006335)5.53180088
16DNA replication-dependent nucleosome organization (GO:0034723)5.53180088
17cellular response to BMP stimulus (GO:0071773)5.39786475
18response to BMP (GO:0071772)5.39786475
19embryonic axis specification (GO:0000578)5.29974551
20L-serine transport (GO:0015825)5.28673561
21embryonic foregut morphogenesis (GO:0048617)5.24354060
22negative regulation of axon extension involved in axon guidance (GO:0048843)5.06896918
23righting reflex (GO:0060013)4.82931021
24dorsal/ventral axis specification (GO:0009950)4.80622862
25negative regulation of cell fate specification (GO:0009996)4.78488834
26regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.57495989
27female gonad development (GO:0008585)4.50315528
28regulation of interleukin-8 secretion (GO:2000482)4.48633228
29Rap protein signal transduction (GO:0032486)4.47516939
30serine transport (GO:0032329)4.45847409
31nodal signaling pathway (GO:0038092)4.38887374
32axis specification (GO:0009798)4.34748368
33regulation of gastrulation (GO:0010470)4.34715037
34regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901214.30824731
35regulation of activation of Janus kinase activity (GO:0010533)4.28776465
36positive regulation of interleukin-8 secretion (GO:2000484)4.26127553
37regulation of axon extension involved in axon guidance (GO:0048841)4.24822693
38uterus development (GO:0060065)4.11942719
39face development (GO:0060324)4.11083699
40CENP-A containing nucleosome assembly (GO:0034080)4.06567428
41fat-soluble vitamin catabolic process (GO:0042363)4.01895342
42vitamin catabolic process (GO:0009111)4.01895342
43positive regulation of gastrulation (GO:2000543)4.00232302
44terpenoid biosynthetic process (GO:0016114)3.98313517
45limb bud formation (GO:0060174)3.96384062
46negative regulation of axon guidance (GO:1902668)3.96104739
47pattern specification involved in kidney development (GO:0061004)3.94780882
48UDP-N-acetylglucosamine metabolic process (GO:0006047)3.89380036
49regulation of acrosome reaction (GO:0060046)3.86629185
50negative regulation of appetite (GO:0032099)3.86544483
51negative regulation of response to food (GO:0032096)3.86544483
52embryonic pattern specification (GO:0009880)3.86240614
53regulation of collateral sprouting (GO:0048670)3.78693920
54response to hepatocyte growth factor (GO:0035728)3.78661499
55cellular response to hepatocyte growth factor stimulus (GO:0035729)3.78661499
56chromatin remodeling at centromere (GO:0031055)3.77283918
57glycosphingolipid biosynthetic process (GO:0006688)3.74776652
58regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.72322870
59negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.65092370
60N-glycan processing (GO:0006491)3.63159931
61regulation of axon guidance (GO:1902667)3.62789427
62regulation of membrane lipid distribution (GO:0097035)3.58877855
63negative regulation of embryonic development (GO:0045992)3.58334697
64histone exchange (GO:0043486)3.56321378
65DNA deamination (GO:0045006)3.52184280
66positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.48751956
67DNA double-strand break processing (GO:0000729)3.48138249
68regulation of cardioblast differentiation (GO:0051890)3.42203047
69positive regulation of protein autophosphorylation (GO:0031954)3.41777947
70regulation of cytokine secretion involved in immune response (GO:0002739)3.40164709
71formation of primary germ layer (GO:0001704)3.38832494
72negative regulation of DNA recombination (GO:0045910)3.34155707
73tryptophan catabolic process (GO:0006569)3.33773708
74indole-containing compound catabolic process (GO:0042436)3.33773708
75indolalkylamine catabolic process (GO:0046218)3.33773708
76amine catabolic process (GO:0009310)3.32684710
77cellular biogenic amine catabolic process (GO:0042402)3.32684710
78pericardium development (GO:0060039)3.31944598
79bile acid biosynthetic process (GO:0006699)3.30682937
80negative regulation of cell fate commitment (GO:0010454)3.28634805
81superoxide anion generation (GO:0042554)3.27831349
82ureteric bud development (GO:0001657)3.26205160
83organ formation (GO:0048645)3.26007750
84embryonic eye morphogenesis (GO:0048048)3.23589933
85DNA replication-independent nucleosome organization (GO:0034724)3.22528852
86DNA replication-independent nucleosome assembly (GO:0006336)3.22528852
87regulation of cell fate specification (GO:0042659)3.21425942
88urea cycle (GO:0000050)3.20470254
89urea metabolic process (GO:0019627)3.20470254
90tryptophan metabolic process (GO:0006568)3.19589120
91reflex (GO:0060004)3.19397480
92production of molecular mediator involved in inflammatory response (GO:0002532)3.18614486
93negative regulation of T cell mediated immunity (GO:0002710)3.17877460
94axoneme assembly (GO:0035082)3.14294503
95cardiocyte differentiation (GO:0035051)3.12898980
96negative regulation of keratinocyte proliferation (GO:0010839)3.09827823
97positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.08573929
98regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.08573929
99fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.06681809
100hair follicle development (GO:0001942)3.06419747
101regulation of mitochondrial depolarization (GO:0051900)3.05059791
102natural killer cell activation involved in immune response (GO:0002323)3.03753043
103kidney morphogenesis (GO:0060993)3.02754435
104sialylation (GO:0097503)3.01405214
105leukocyte aggregation (GO:0070486)3.00052607
106replication fork processing (GO:0031297)3.00035705
107aromatic amino acid family catabolic process (GO:0009074)2.98903180
108positive regulation of protein oligomerization (GO:0032461)2.97661839
109positive regulation of mast cell activation (GO:0033005)2.96464220
110regulation of MHC class I biosynthetic process (GO:0045343)2.95969044
111atrial cardiac muscle cell action potential (GO:0086014)2.94755420
112mesonephric tubule development (GO:0072164)2.94256083
113regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.94184760
114mesoderm formation (GO:0001707)2.93973444
115activin receptor signaling pathway (GO:0032924)2.92989919
116interferon-gamma production (GO:0032609)2.91721086
117positive regulation of mast cell activation involved in immune response (GO:0033008)2.91206299
118positive regulation of mast cell degranulation (GO:0043306)2.91206299
119alkaloid metabolic process (GO:0009820)2.90443891
120retinol metabolic process (GO:0042572)2.90246784
121branch elongation of an epithelium (GO:0060602)2.88983160
122drug transmembrane transport (GO:0006855)2.88657265
123glomerulus development (GO:0032835)2.87997642
124phosphatidylinositol acyl-chain remodeling (GO:0036149)2.87570624
125positive regulation of lymphocyte migration (GO:2000403)2.87568349
126pre-miRNA processing (GO:0031054)2.86809210
127embryonic camera-type eye morphogenesis (GO:0048596)2.86350424
128nitrogen cycle metabolic process (GO:0071941)2.86085657
129positive regulation of T cell migration (GO:2000406)2.85403259
130mesonephric epithelium development (GO:0072163)2.84956846
131positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.84724151
132regulation of mononuclear cell migration (GO:0071675)2.83338136
133embryonic retina morphogenesis in camera-type eye (GO:0060059)2.83051567
134positive regulation of cardiac muscle tissue development (GO:0055025)2.82727699
135craniofacial suture morphogenesis (GO:0097094)2.82338067
136negative regulation of BMP signaling pathway (GO:0030514)2.78235315
137sphingosine metabolic process (GO:0006670)2.76974185
138outflow tract septum morphogenesis (GO:0003148)2.76661260
139mitotic G2/M transition checkpoint (GO:0044818)2.74723743
140mitotic G2 DNA damage checkpoint (GO:0007095)2.74164701
141regulation of T cell chemotaxis (GO:0010819)2.72825098
142positive regulation of T cell chemotaxis (GO:0010820)2.72825098
143eosinophil chemotaxis (GO:0048245)2.71086589
144sterol biosynthetic process (GO:0016126)2.70801650
145neutrophil activation involved in immune response (GO:0002283)2.70385302
146SMAD protein complex assembly (GO:0007183)2.68628539
147detection of other organism (GO:0098543)2.68502146
148dendritic cell migration (GO:0036336)2.68092430
149SMAD protein signal transduction (GO:0060395)2.67244948
150lipid particle organization (GO:0034389)2.66195596
151positive regulation of muscle organ development (GO:0048636)2.66160494
152positive regulation of striated muscle tissue development (GO:0045844)2.66160494
153glyoxylate metabolic process (GO:0046487)2.66137925
154resolution of meiotic recombination intermediates (GO:0000712)2.65751207
155regulation of lymphocyte chemotaxis (GO:1901623)2.65477530
156mesenchymal to epithelial transition (GO:0060231)2.62685745
157regulation of cell fate commitment (GO:0010453)2.62168601
158cellular response to nicotine (GO:0071316)2.61795225
159proteasome assembly (GO:0043248)2.61589556
160regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.61146037
161regulation of endothelial cell differentiation (GO:0045601)2.60898119
162cardiac muscle cell differentiation (GO:0055007)2.60884848
163complement activation, alternative pathway (GO:0006957)2.58853775
164regulation of response to food (GO:0032095)2.58460767
165indolalkylamine metabolic process (GO:0006586)2.57994574
166kynurenine metabolic process (GO:0070189)2.57919190
167positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.56971934
168erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.56759998
169L-phenylalanine catabolic process (GO:0006559)2.56759998
170cellular extravasation (GO:0045123)2.56726129
171hydrogen peroxide biosynthetic process (GO:0050665)2.55982770
172regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.53251146
173positive regulation of interleukin-1 beta secretion (GO:0050718)2.51802812
174cilium movement (GO:0003341)2.51324225
175sphingoid metabolic process (GO:0046519)2.51092682
176aromatic amino acid family metabolic process (GO:0009072)2.48654438
177positive regulation of endothelial cell differentiation (GO:0045603)2.48619258
178regulation of alkaline phosphatase activity (GO:0010692)2.45734867
179regulation of RIG-I signaling pathway (GO:0039535)2.45431773
180response to peptidoglycan (GO:0032494)2.44307862
181regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.44185800
182regulation of protein activation cascade (GO:2000257)2.43922188
183positive regulation of humoral immune response (GO:0002922)2.43906643
184phospholipid efflux (GO:0033700)2.41017778
185retinoic acid metabolic process (GO:0042573)2.40481125
186presynaptic membrane organization (GO:0097090)2.39777328
187erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.36758004
188L-phenylalanine metabolic process (GO:0006558)2.36758004
189positive regulation of interleukin-1 secretion (GO:0050716)2.36056120
190tyrosine metabolic process (GO:0006570)2.35156763
191regulation of interleukin-1 beta secretion (GO:0050706)2.34765030
192positive regulation of T-helper 1 type immune response (GO:0002827)2.33770421
193detection of molecule of bacterial origin (GO:0032490)2.33254219
194regulation of plasminogen activation (GO:0010755)2.33250636
195energy homeostasis (GO:0097009)2.33120242
196phospholipid scrambling (GO:0017121)12.0519343
197regulation of mesoderm development (GO:2000380)11.6208758
198sequestering of extracellular ligand from receptor (GO:0035581)10.1755307

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD3_21741376_ChIP-Seq_HESCs_Human4.31028693
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.57249511
3SMAD4_21741376_ChIP-Seq_HESCs_Human3.52916489
4SMAD3_21741376_ChIP-Seq_EPCs_Human3.10479961
5WT1_19549856_ChIP-ChIP_CCG9911_Human2.87653171
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.76479557
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.68909600
8EOMES_21245162_ChIP-Seq_HESCs_Human2.66194877
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.56763911
10POU5F1_16153702_ChIP-ChIP_HESCs_Human2.55255675
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.52343225
12SMAD2/3_21741376_ChIP-Seq_EPCs_Human2.51958860
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.35305430
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.31039039
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.30712458
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.30712458
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.30712458
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.21149111
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.17267907
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.13298033
21SMAD4_21741376_ChIP-Seq_EPCs_Human2.12553162
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.11012804
23E2F7_22180533_ChIP-Seq_HELA_Human2.05199673
24CDX2_19796622_ChIP-Seq_MESCs_Mouse2.04647154
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04263311
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02034536
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.01523956
28NANOG_16153702_ChIP-ChIP_HESCs_Human2.00187053
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.96681133
30ELK1_19687146_ChIP-ChIP_HELA_Human1.96568835
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.95577719
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.95119000
33EWS_26573619_Chip-Seq_HEK293_Human1.94909528
34VDR_22108803_ChIP-Seq_LS180_Human1.87837225
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.86282939
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85421403
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84528833
38BCAT_22108803_ChIP-Seq_LS180_Human1.83653499
39NFE2_27457419_Chip-Seq_LIVER_Mouse1.82783994
40TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.80305568
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.79512020
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79172771
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73474949
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.72299949
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.70884999
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.70743232
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.70385192
48NANOG_18555785_Chip-Seq_ESCs_Mouse1.65878156
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65656681
50GBX2_23144817_ChIP-Seq_PC3_Human1.64030486
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.62678025
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.62490466
53ZNF274_21170338_ChIP-Seq_K562_Hela1.62351388
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.62194808
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61685560
56RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.60789336
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60182548
58P53_22387025_ChIP-Seq_ESCs_Mouse1.60087125
59CRX_20693478_ChIP-Seq_RETINA_Mouse1.59921402
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.57605844
61STAT3_18555785_Chip-Seq_ESCs_Mouse1.57598541
62SUZ12_18555785_Chip-Seq_ESCs_Mouse1.56913652
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.56713387
64RXR_22158963_ChIP-Seq_LIVER_Mouse1.56647805
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.53292447
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53194263
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53081514
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.51137600
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.50798388
70OCT4_18555785_Chip-Seq_ESCs_Mouse1.50416854
71FUS_26573619_Chip-Seq_HEK293_Human1.49784856
72NMYC_18555785_Chip-Seq_ESCs_Mouse1.48126914
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.47700967
74OCT4_21477851_ChIP-Seq_ESCs_Mouse1.47455191
75IRF8_22096565_ChIP-ChIP_GC-B_Human1.47397008
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45407896
77SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.45231306
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44947369
79IRF8_27001747_Chip-Seq_BMDM_Mouse1.44401482
80SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44152204
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44031725
82FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.43154554
83LXR_22158963_ChIP-Seq_LIVER_Mouse1.42728471
84SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.41919679
85P300_19829295_ChIP-Seq_ESCs_Human1.41549629
86SOX2_18555785_Chip-Seq_ESCs_Mouse1.41260791
87P300_18555785_Chip-Seq_ESCs_Mouse1.41066708
88ZFX_18555785_Chip-Seq_ESCs_Mouse1.40018950
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39601559
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.39205187
91SMAD1_18555785_Chip-Seq_ESCs_Mouse1.39022851
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38261163
93TAF15_26573619_Chip-Seq_HEK293_Human1.37211053
94JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35856373
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35712663
96TCF3_18692474_ChIP-Seq_MEFs_Mouse1.34564593
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34470515
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34326780
99IGF1R_20145208_ChIP-Seq_DFB_Human1.34264305
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.33414939
101EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.33151218
102SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.31202511
103RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31132153
104EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31132153
105RUNX1_27457419_Chip-Seq_LIVER_Mouse1.29800990
106PU1_27457419_Chip-Seq_LIVER_Mouse1.26930590
107EZH2_27304074_Chip-Seq_ESCs_Mouse1.26591670
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.26123238
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25671898
110NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25671898
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25273768
112CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24994714
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24633333
114CBP_20019798_ChIP-Seq_JUKART_Human1.23182092
115IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23182092
116FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22695415
117KLF4_18555785_Chip-Seq_ESCs_Mouse1.22456864
118KAP1_22055183_ChIP-Seq_ESCs_Mouse1.22407724
119TP53_18474530_ChIP-ChIP_U2OS_Human1.22052442
120PIAS1_25552417_ChIP-Seq_VCAP_Human1.21749413
121KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21316278
122CTCF_18555785_Chip-Seq_ESCs_Mouse1.21220348
123NANOG_19829295_ChIP-Seq_ESCs_Human1.20974203
124SOX2_19829295_ChIP-Seq_ESCs_Human1.20974203
125MYC_18940864_ChIP-ChIP_HL60_Human1.20962227
126RNF2_27304074_Chip-Seq_NSC_Mouse1.20935686
127EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20695591
128CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19898217
129NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.19738158
130CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19339729
131STAT1_17558387_ChIP-Seq_HELA_Human1.18462399
132TCF4_22108803_ChIP-Seq_LS180_Human1.16200915
133EZH2_27294783_Chip-Seq_ESCs_Mouse1.16078456
134VDR_24787735_ChIP-Seq_THP-1_Human1.14342477
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14211235
136ESRRB_18555785_Chip-Seq_ESCs_Mouse1.14162838
137SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13270716
138PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13138518
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12990775
140SMAD3_21741376_ChIP-Seq_ESCs_Human1.12859764
141CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12432748
142TBX3_20139965_ChIP-Seq_MESCs_Mouse1.12384455
143TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11421126
144PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10726745
145SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10607186
146AR_25329375_ChIP-Seq_VCAP_Human1.10449300
147FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09370490
148IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08763703
149AR_21909140_ChIP-Seq_LNCAP_Human1.08466507
150RUNX2_22187159_ChIP-Seq_PCA_Human1.08342423
151AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08334647
152POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07948263
153ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07925488
154MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06869578
155PRDM14_20953172_ChIP-Seq_ESCs_Human1.06738671
156HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06564368
157* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06091200
158ER_23166858_ChIP-Seq_MCF-7_Human1.05478525
159TCF4_18268006_ChIP-ChIP_LS174T_Human1.05016632
160FOXM1_23109430_ChIP-Seq_U2OS_Human1.04941726
161SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04440681
162AR_21572438_ChIP-Seq_LNCaP_Human1.03496024
163RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03278425
164CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03129361
165TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02558628
166POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02558628
167STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02188671
168PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97725817
169* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96841966
170SMAD4_21799915_ChIP-Seq_A2780_Human0.96812787
171KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95981347
172CDX2_22108803_ChIP-Seq_LS180_Human0.95582736

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005248_abnormal_Harderian_gland5.53867342
2MP0005360_urolithiasis4.18235046
3MP0003119_abnormal_digestive_system3.79956884
4MP0003879_abnormal_hair_cell3.42531869
5MP0005085_abnormal_gallbladder_physiolo3.34346477
6MP0002139_abnormal_hepatobiliary_system3.15094198
7MP0005623_abnormal_meninges_morphology3.12980977
8MP0005499_abnormal_olfactory_system3.11757789
9MP0005394_taste/olfaction_phenotype3.11757789
10MP0004381_abnormal_hair_follicle3.09232409
11MP0005451_abnormal_body_composition3.04131748
12MP0002009_preneoplasia2.91291800
13MP0003136_yellow_coat_color2.80655080
14MP0003011_delayed_dark_adaptation2.77976243
15MP0008995_early_reproductive_senescence2.53017171
16MP0008004_abnormal_stomach_pH2.48300230
17MP0009785_altered_susceptibility_to2.34900719
18MP0002148_abnormal_hypersensitivity_rea2.32693888
19MP0010030_abnormal_orbit_morphology2.32015904
20MP0003436_decreased_susceptibility_to2.25853599
21MP0003941_abnormal_skin_development2.25513421
22MP0005171_absent_coat_pigmentation2.23890621
23MP0002138_abnormal_hepatobiliary_system2.23703239
24MP0003252_abnormal_bile_duct2.20697371
25MP0003724_increased_susceptibility_to2.16162317
26MP0003880_abnormal_central_pattern2.05539191
27MP0003890_abnormal_embryonic-extraembry12.8691947
28MP0000026_abnormal_inner_ear1.97326627
29MP0004957_abnormal_blastocyst_morpholog1.95533467
30MP0005423_abnormal_somatic_nervous1.89061531
31MP0001293_anophthalmia1.88525344
32MP0002084_abnormal_developmental_patter1.86104016
33MP0009764_decreased_sensitivity_to1.80186091
34MP0006082_CNS_inflammation1.80016446
35MP0008875_abnormal_xenobiotic_pharmacok1.79290215
36MP0009697_abnormal_copulation1.75861995
37MP0001984_abnormal_olfaction1.74492410
38MP0002249_abnormal_larynx_morphology1.72069545
39MP0002132_abnormal_respiratory_system1.70624052
40MP0001963_abnormal_hearing_physiology1.69967675
41MP0003385_abnormal_body_wall1.69706428
42MP0009379_abnormal_foot_pigmentation1.67047212
43MP0003943_abnormal_hepatobiliary_system1.66130677
44MP0006072_abnormal_retinal_apoptosis1.59522459
45MP0005025_abnormal_response_to1.58482462
46MP0001529_abnormal_vocalization1.56909685
47MP0002098_abnormal_vibrissa_morphology1.54963450
48MP0001672_abnormal_embryogenesis/_devel1.54280530
49MP0005380_embryogenesis_phenotype1.54280530
50MP0004019_abnormal_vitamin_homeostasis1.52596485
51MP0002419_abnormal_innate_immunity1.51393912
52MP0005365_abnormal_bile_salt1.50651053
53MP0002277_abnormal_respiratory_mucosa1.50249392
54MP0002111_abnormal_tail_morphology1.48390196
55MP0000579_abnormal_nail_morphology1.47620087
56MP0003938_abnormal_ear_development1.43141923
57MP0005671_abnormal_response_to1.39255950
58MP0002736_abnormal_nociception_after1.36701575
59MP0002796_impaired_skin_barrier1.36339146
60MP0001286_abnormal_eye_development1.33306672
61MP0005000_abnormal_immune_tolerance1.31540211
62MP0005275_abnormal_skin_tensile1.29178398
63MP0002938_white_spotting1.26659517
64MP0000613_abnormal_salivary_gland1.26253756
65MP0002006_tumorigenesis1.23085542
66MP0000490_abnormal_crypts_of1.23034821
67MP0002735_abnormal_chemical_nociception1.22128142
68MP0000428_abnormal_craniofacial_morphol1.21899718
69MP0008438_abnormal_cutaneous_collagen1.21223470
70MP0000462_abnormal_digestive_system1.20999112
71MP0005408_hypopigmentation1.20802267
72MP0002085_abnormal_embryonic_tissue1.20303127
73MP0002282_abnormal_trachea_morphology1.19643672
74MP0003786_premature_aging1.16189235
75MP0001800_abnormal_humoral_immune1.16071221
76MP0008932_abnormal_embryonic_tissue1.15723108
77MP0002102_abnormal_ear_morphology1.15659090
78MP0009250_abnormal_appendicular_skeleto1.13694998
79MP0002723_abnormal_immune_serum1.13153538
80MP0010094_abnormal_chromosome_stability1.12498443
81MP0005464_abnormal_platelet_physiology1.11036262
82MP0003186_abnormal_redox_activity1.10013793
83MP0008789_abnormal_olfactory_epithelium1.09730173
84MP0005387_immune_system_phenotype1.09331768
85MP0001790_abnormal_immune_system1.09331768
86MP0003942_abnormal_urinary_system1.08834337
87MP0002109_abnormal_limb_morphology1.08609499
88MP0005647_abnormal_sex_gland1.08032584
89MP0004215_abnormal_myocardial_fiber1.06253960
90MP0001727_abnormal_embryo_implantation1.05744145
91MP0010329_abnormal_lipoprotein_level1.05484612
92MP0002233_abnormal_nose_morphology1.04353294
93MP0001177_atelectasis1.04261088
94MP0002452_abnormal_antigen_presenting1.02758443
95MP0000465_gastrointestinal_hemorrhage1.01350427
96MP0010155_abnormal_intestine_physiology0.99516425
97MP0003984_embryonic_growth_retardation0.98828933
98MP0003566_abnormal_cell_adhesion0.98243902
99MP0003935_abnormal_craniofacial_develop0.98069615
100MP0002088_abnormal_embryonic_growth/wei0.98054418
101MP0008469_abnormal_protein_level0.96060793
102MP0001730_embryonic_growth_arrest0.95517718
103MP0001533_abnormal_skeleton_physiology0.95192711
104MP0002127_abnormal_cardiovascular_syste0.94748035
105MP0001764_abnormal_homeostasis0.92818164
106MP0000566_synostosis0.92447429
107MP0003936_abnormal_reproductive_system0.91800035
108MP0009765_abnormal_xenobiotic_induced0.91215449
109MP0003303_peritoneal_inflammation0.90922318
110MP0003195_calcinosis0.90642183
111MP0004510_myositis0.90510270
112MP0000383_abnormal_hair_follicle0.90200297
113MP0009763_increased_sensitivity_to0.88891457
114MP0000372_irregular_coat_pigmentation0.88017748
115MP0002932_abnormal_joint_morphology0.87933787
116MP0006292_abnormal_olfactory_placode0.87028085
117MP0003137_abnormal_impulse_conducting0.85910108
118MP0001845_abnormal_inflammatory_respons0.85800433
119MP0001485_abnormal_pinna_reflex0.85029803
120MP0002086_abnormal_extraembryonic_tissu0.83784034
121MP0001819_abnormal_immune_cell0.82950555
122MP0000762_abnormal_tongue_morphology0.81799871
123MP0006054_spinal_hemorrhage0.81796054
124MP0000432_abnormal_head_morphology0.81492850
125MP0002116_abnormal_craniofacial_bone0.80949306
126MP0002420_abnormal_adaptive_immunity0.80819189
127MP0001881_abnormal_mammary_gland0.80638880
128MP0003806_abnormal_nucleotide_metabolis0.79351909
129MP0005535_abnormal_body_temperature0.78534295
130MP0003755_abnormal_palate_morphology0.78376507
131MP0001835_abnormal_antigen_presentation0.77297428
132MP0003279_aneurysm0.76461187
133MP0001188_hyperpigmentation0.75866383
134MP0002933_joint_inflammation0.74499134
135MP0005257_abnormal_intraocular_pressure0.72731913
136MP0002115_abnormal_skeleton_extremities0.72462031
137MP0001697_abnormal_embryo_size0.71446234
138MP0005253_abnormal_eye_physiology0.70842212
139MP0010678_abnormal_skin_adnexa0.69492824
140MP0000163_abnormal_cartilage_morphology0.69063827
141MP0005391_vision/eye_phenotype0.68783501
142MP0004742_abnormal_vestibular_system0.68176725
143MP0008872_abnormal_physiological_respon0.68098916
144MP0002080_prenatal_lethality0.68063315
145MP0000377_abnormal_hair_follicle0.67034858
146MP0005319_abnormal_enzyme/_coenzyme0.67000346
147MP0005084_abnormal_gallbladder_morpholo0.66813016
148MP0008058_abnormal_DNA_repair0.65995507
149MP0003861_abnormal_nervous_system0.65666367
150MP0005551_abnormal_eye_electrophysiolog0.65562375
151MP0003453_abnormal_keratinocyte_physiol0.64906738
152MP0005076_abnormal_cell_differentiation0.63987837
153MP0002254_reproductive_system_inflammat0.63578608
154MP0003937_abnormal_limbs/digits/tail_de0.63461267
155MP0000049_abnormal_middle_ear0.62898134
156MP0003567_abnormal_fetal_cardiomyocyte0.62797110
157MP0004782_abnormal_surfactant_physiolog0.61576672
158MP0005670_abnormal_white_adipose0.60075432
159MP0004133_heterotaxia0.59263174
160MP0002751_abnormal_autonomic_nervous0.58852508
161MP0009384_cardiac_valve_regurgitation0.58395427
162MP0001666_abnormal_nutrient_absorption0.58371182
163MP0002396_abnormal_hematopoietic_system0.57765372
164MP0004272_abnormal_basement_membrane0.57546204
165MP0002925_abnormal_cardiovascular_devel0.57010580
166MP0000569_abnormal_digit_pigmentation0.56485555
167MP0002114_abnormal_axial_skeleton0.54481712
168MP0002092_abnormal_eye_morphology0.53692774
169MP0000358_abnormal_cell_content/0.52912454
170MP0003121_genomic_imprinting0.50807190
171MP0001968_abnormal_touch/_nociception0.49400948
172MP0001119_abnormal_female_reproductive0.49249550
173MP0003077_abnormal_cell_cycle0.48107412
174MP0002210_abnormal_sex_determination0.47954696
175MP0004085_abnormal_heartbeat0.47194334
176MP0003693_abnormal_embryo_hatching0.46921974
177MP0001929_abnormal_gametogenesis0.44296748
178MP0010368_abnormal_lymphatic_system0.43518596

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fetal cardiovascular system (HP:0010948)6.50952978
2Abnormal umbilical cord blood vessels (HP:0011403)6.50952978
3Single umbilical artery (HP:0001195)6.50952978
4Epiphyseal dysplasia (HP:0002656)5.50485397
5Intrahepatic cholestasis (HP:0001406)5.27782348
6Abnormal pancreas size (HP:0012094)5.13642312
7Anal stenosis (HP:0002025)5.08202883
8Recurrent gram-negative bacterial infections (HP:0005420)5.06251081
9Hypoplastic pelvis (HP:0008839)4.65801337
10Abnormality of the umbilical cord (HP:0010881)4.48525075
11Abnormal ciliary motility (HP:0012262)4.40959841
12Rectal fistula (HP:0100590)4.40197779
13Rectovaginal fistula (HP:0000143)4.40197779
14Septo-optic dysplasia (HP:0100842)4.35916637
15Chromosomal breakage induced by crosslinking agents (HP:0003221)4.22578915
16Severe Myopia (HP:0011003)4.14855746
17Rhinitis (HP:0012384)4.05406388
18Abnormal respiratory motile cilium physiology (HP:0012261)4.05294411
19Abdominal situs inversus (HP:0003363)3.97407113
20Abnormality of abdominal situs (HP:0011620)3.97407113
21Double outlet right ventricle (HP:0001719)3.83744009
22Congenital malformation of the right heart (HP:0011723)3.83744009
23Gonadotropin excess (HP:0000837)3.79695611
24Abnormal respiratory motile cilium morphology (HP:0005938)3.78549976
25Abnormal respiratory epithelium morphology (HP:0012253)3.78549976
26Abnormality of pyrimidine metabolism (HP:0004353)3.77515852
27Asplenia (HP:0001746)3.75124208
28Intestinal fistula (HP:0100819)3.72001259
29Volvulus (HP:0002580)3.71567944
30Recurrent bacterial skin infections (HP:0005406)3.71214521
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.70875047
32Vitreoretinal degeneration (HP:0000655)3.70415007
33Vaginal fistula (HP:0004320)3.69746457
34Abnormal lung lobation (HP:0002101)3.59653950
35Aplasia/Hypoplasia of the spleen (HP:0010451)3.55631628
36Eczematoid dermatitis (HP:0000976)3.49173135
37Recurrent abscess formation (HP:0002722)3.39454393
38Bifid tongue (HP:0010297)3.36762818
39Tubulointerstitial nephritis (HP:0001970)3.36198271
40Optic nerve hypoplasia (HP:0000609)3.35534478
41Chromsome breakage (HP:0040012)3.27194851
42Anophthalmia (HP:0000528)3.15877631
43Short humerus (HP:0005792)3.14067232
44Short middle phalanx of the 5th finger (HP:0004220)3.09356860
45Anteriorly placed anus (HP:0001545)3.07086805
46Mesomelia (HP:0003027)3.06065235
47Aplasia/hypoplasia of the humerus (HP:0006507)3.02407140
48Joint hemorrhage (HP:0005261)2.98853696
49Prolonged partial thromboplastin time (HP:0003645)2.98579039
50Periauricular skin pits (HP:0100277)2.97814305
51Preauricular pit (HP:0004467)2.97814305
52Mild short stature (HP:0003502)2.94861364
53Abnormalities of placenta or umbilical cord (HP:0001194)2.88851810
54Ectopic anus (HP:0004397)2.87699281
55Abnormality of monocarboxylic acid metabolism (HP:0010996)2.85331823
56Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.82464225
57Deep venous thrombosis (HP:0002625)2.81452491
58Gonadal dysgenesis (HP:0000133)2.75108549
59Keratoconjunctivitis sicca (HP:0001097)2.73397766
60Abnormal vertebral ossification (HP:0100569)2.72126519
61Patent foramen ovale (HP:0001655)2.67701985
62Abnormal ventriculo-arterial connection (HP:0011563)2.64714095
63Transposition of the great arteries (HP:0001669)2.64714095
64Abnormal connection of the cardiac segments (HP:0011545)2.64714095
65Mediastinal lymphadenopathy (HP:0100721)2.61746624
66Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.60876305
67Anal atresia (HP:0002023)2.60478019
68Alopecia of scalp (HP:0002293)2.60449406
69Complement deficiency (HP:0004431)2.59794138
70Fat malabsorption (HP:0002630)2.56925735
71Abnormality of the aortic arch (HP:0012303)2.53236001
72Ureteral duplication (HP:0000073)2.52664332
73Prostate neoplasm (HP:0100787)2.51139003
74Dynein arm defect of respiratory motile cilia (HP:0012255)2.48074380
75Absent/shortened dynein arms (HP:0200106)2.48074380
76Lip pit (HP:0100267)2.46018341
77Hypotrichosis (HP:0001006)2.42905764
78Keratoconjunctivitis (HP:0001096)2.41541301
79Enlarged epiphyses (HP:0010580)2.41473236
80Optic neuritis (HP:0100653)2.40766083
81Retrobulbar optic neuritis (HP:0100654)2.40766083
82Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.37757797
83Encephalitis (HP:0002383)2.37003123
84Premature rupture of membranes (HP:0001788)2.36076221
85Recurrent sinusitis (HP:0011108)2.35998444
86Midline defect of the nose (HP:0004122)2.35338328
87Cortical dysplasia (HP:0002539)2.33028371
88Hydroxyprolinuria (HP:0003080)2.31561525
89Abnormality of proline metabolism (HP:0010907)2.31561525
90Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.30922566
91Abnormality of the parathyroid morphology (HP:0011766)2.30726927
92Abnormality of the pubic bones (HP:0003172)2.29880534
93Systemic lupus erythematosus (HP:0002725)2.25373947
94Chronic hepatic failure (HP:0100626)2.23939960
95Recurrent skin infections (HP:0001581)2.23620716
96Skull defect (HP:0001362)2.23506273
97Abnormality of chromosome stability (HP:0003220)2.23403548
98Recurrent pneumonia (HP:0006532)2.22555857
99Absent septum pellucidum (HP:0001331)2.22469040
100Congenital, generalized hypertrichosis (HP:0004540)2.19041156
101Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.16847562
102Decreased central vision (HP:0007663)2.16517097
103Bilateral microphthalmos (HP:0007633)2.15486673
104Pancreatic islet-cell hyperplasia (HP:0004510)2.13883088
105Abnormality of the phalanges of the 5th finger (HP:0004213)2.13734487
106Orchitis (HP:0100796)2.11619819
107Irregular epiphyses (HP:0010582)2.10228471
108Abnormality of the septum pellucidum (HP:0007375)2.05122716
109Vaginal atresia (HP:0000148)2.05098126
110Abnormality of aromatic amino acid family metabolism (HP:0004338)2.04615941
111Aplasia/Hypoplasia of the uvula (HP:0010293)2.04241812
112Shawl scrotum (HP:0000049)2.04191462
113Gingivitis (HP:0000230)2.03232657
114Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.02224347
115Multiple enchondromatosis (HP:0005701)2.02159193
116Abnormality of the axillary hair (HP:0100134)2.01865342
117Abnormality of secondary sexual hair (HP:0009888)2.01865342
118Abnormality of the vitreous humor (HP:0004327)2.00966979
119Nephronophthisis (HP:0000090)2.00569724
120Concave nail (HP:0001598)1.98621290
121Adactyly (HP:0009776)1.98156390
122Genital tract atresia (HP:0001827)1.96860225
123Labial hypoplasia (HP:0000066)1.96089241
124Proximal placement of thumb (HP:0009623)1.95793448
125Intestinal atresia (HP:0011100)1.95407873
126Myositis (HP:0100614)1.95203936
127Abnormality of nucleobase metabolism (HP:0010932)1.95169173
128Gangrene (HP:0100758)1.94384442
129Abnormality of methionine metabolism (HP:0010901)1.93605801
130Stomatitis (HP:0010280)1.93156301
131Prolonged neonatal jaundice (HP:0006579)1.93076305
132Hypophosphatemic rickets (HP:0004912)1.92943026
133Myelomeningocele (HP:0002475)1.91874987
134Amyloidosis (HP:0011034)1.91595184
135Preaxial foot polydactyly (HP:0001841)1.91106999
136Menorrhagia (HP:0000132)1.91034565
137Abnormality of the prostate (HP:0008775)1.90533628
138Bronchiectasis (HP:0002110)1.90046278
139Pustule (HP:0200039)1.89535568
140Hypoplastic female external genitalia (HP:0012815)1.89012441
141Chronic obstructive pulmonary disease (HP:0006510)1.88375581
142Obstructive lung disease (HP:0006536)1.88375581
143Prominent supraorbital ridges (HP:0000336)1.88312131
144Retinopathy (HP:0000488)1.87684703
145Methylmalonic acidemia (HP:0002912)1.86559734
146Abnormality of the common coagulation pathway (HP:0010990)1.85800337
147Abnormal foot bone ossification (HP:0010675)1.85524744
148Alveolar cell carcinoma (HP:0006519)1.85369523
149Gastrointestinal infarctions (HP:0005244)1.85146920
150Vascular calcification (HP:0004934)1.84793858
151Absent radius (HP:0003974)1.83228240
152Amniotic constriction ring (HP:0009775)1.82908827
153Abnormality of placental membranes (HP:0011409)1.82908827
154Parakeratosis (HP:0001036)1.82279541
155Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82273255
156Hepatitis (HP:0012115)1.82096538
157Tracheal stenosis (HP:0002777)1.81790359
158Abnormality of complement system (HP:0005339)1.81307355
159Chronic sinusitis (HP:0011109)1.81131347
160Oligodactyly (hands) (HP:0001180)1.80903099
161Deviation of the thumb (HP:0009603)1.80662753
162Abnormal biliary tract physiology (HP:0012439)1.80635962
163Bile duct proliferation (HP:0001408)1.80635962
164Hypoplasia of the fovea (HP:0007750)1.80300729
165Aplasia/Hypoplasia of the fovea (HP:0008060)1.80300729
166Hypokinesia (HP:0002375)1.80059700
167Congenital ichthyosiform erythroderma (HP:0007431)1.79919336
168Limb dystonia (HP:0002451)1.79157461
169Renal dysplasia (HP:0000110)1.77967513
170Scrotal hypoplasia (HP:0000046)1.77322444
171Abnormality of glutamine family amino acid metabolism (HP:0010902)1.77296351
172Ependymoma (HP:0002888)1.76456166
173Neoplasm of the adrenal gland (HP:0100631)1.76195527
174Dry hair (HP:0011359)1.72885125
175Small hand (HP:0200055)1.72127954
176Increased serum pyruvate (HP:0003542)1.71718486
177Abnormality of male internal genitalia (HP:0000022)1.71616755
178Abnormality of the lacrimal duct (HP:0011481)1.70444378
179Recurrent lower respiratory tract infections (HP:0002783)1.70263275
180Prolonged bleeding time (HP:0003010)1.70163146
181Absent forearm bone (HP:0003953)1.69685059
182Aplasia involving forearm bones (HP:0009822)1.69685059
183Fused cervical vertebrae (HP:0002949)1.69387626
184Meningitis (HP:0001287)1.68808511
185Vasculitis (HP:0002633)1.68701355
186Steatorrhea (HP:0002570)1.67551206
187Chronic bronchitis (HP:0004469)1.67134996
188Hypoalphalipoproteinemia (HP:0003233)1.66861245

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.71882331
2CASK6.16073600
3MKNK24.36271966
4TRIM284.21464907
5DDR23.44880210
6MAP3K143.44009413
7MKNK12.77514034
8WNK32.77400567
9SIK32.70068005
10TXK2.66328666
11STK242.62344609
12TGFBR12.60623953
13TRPM72.58445030
14PLK42.36126802
15BMPR22.35308963
16PKN22.34443278
17IRAK42.07706811
18CSNK1G11.97997506
19NUAK11.84154817
20FLT31.74174897
21STK38L1.70301849
22TNIK1.69351418
23MAP3K41.66124670
24STK31.65857289
25CSNK1G31.65242144
26MST41.64970522
27CSNK1A1L1.60064758
28EIF2AK31.50311912
29MAPKAPK51.46703108
30PBK1.46465475
31ADRBK21.41916262
32BCR1.41309056
33PIM21.40601014
34CSNK1G21.37744811
35NEK11.34411414
36MAP3K91.33657739
37MUSK1.32868838
38MST1R1.32569530
39ERBB41.25204015
40ZAK1.23976109
41ADRBK11.23264590
42YES11.19182529
43SRPK11.18947102
44PIM11.17932513
45CSK1.17260266
46EIF2AK21.15160208
47PRKD21.13254169
48ERBB31.11766342
49GRK11.10443782
50BMPR1B1.10416656
51NLK1.10338571
52NEK91.09938307
53FGR1.08351311
54CDC71.07479486
55IKBKE1.07273206
56PNCK1.02244617
57MELK1.01545198
58MAP3K121.01305262
59JAK11.00109683
60NME20.99409022
61IRAK30.99067947
62PLK30.95936164
63FES0.94820560
64TGFBR20.92357910
65TBK10.92187047
66WEE10.92005896
67ABL20.91200883
68CSF1R0.90199842
69MAP3K130.88048540
70PKN10.87035411
71RIPK10.86169654
72HCK0.85866674
73TAF10.83986828
74CLK10.82844699
75DAPK20.82016058
76ABL10.81206176
77STK390.79193666
78BLK0.78539982
79EPHA30.78538332
80TTK0.77795306
81GRK70.77718554
82LRRK20.77214398
83PRKCH0.76815157
84MAP3K80.75406011
85BCKDK0.73793337
86EPHA20.73304434
87EPHA40.71508472
88MARK30.70326257
89PAK30.70012363
90RIPK40.68695933
91EPHB20.67132099
92IRAK10.66161936
93PRKD30.60869444
94LYN0.60191911
95DMPK0.59692037
96WNK40.59676392
97MAP2K70.58823825
98PLK20.57898784
99IKBKB0.57742953
100MAP4K20.57595435
101ROCK20.56326830
102MAPK40.55944591
103BTK0.55802467
104TAOK30.55674342
105PRKCE0.55109293
106JAK20.54829093
107MAP2K10.53967782
108ROCK10.51636512
109FGFR40.51109497
110SYK0.50885320
111STK100.50297478
112PTK60.48868049
113KSR10.47669797
114FGFR10.47483056
115IRAK20.47366235
116CDK60.46803918
117PIK3CG0.46291330
118PRKCQ0.45783518
119TESK10.44855729
120PLK10.43670026
121PRKCG0.43275027
122FRK0.42980985
123STK40.41664166
124MAP2K40.41338200
125MOS0.39631974
126MINK10.39381906
127MAPKAPK30.38423042
128TEC0.37813046
129EIF2AK10.37378703
130RAF10.37180482
131NEK20.37076633
132PRKACB0.36945429
133CAMK2G0.35328900
134PDK20.35181624
135TSSK60.34967178
136INSRR0.34599528
137VRK10.33981877
138CAMK2A0.33251573
139CSNK1A10.32985285
140OXSR10.31411462
141TNK20.30986191
142ATR0.30474692
143ITK0.30150777
144CHUK0.27051331
145LATS20.26915924
146ARAF0.26036525
147ATM0.25989020
148TYK20.24831524
149MAPK130.24522004
150NTRK30.24152463
151PRKACA0.21654058
152ZAP700.21166665
153FER0.20517606
154CDK180.19981983
155PRKCD0.13008533
156OBSCN0.10523985
157NTRK20.10076775
158IGF1R0.09829522
159PRKDC0.09283094
160PAK10.07587978
161ILK0.06415222
162PRKCB0.04915615
163AURKB0.04261360

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.22668682
2Phenylalanine metabolism_Homo sapiens_hsa003603.46898478
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.24909595
4Protein export_Homo sapiens_hsa030603.22088523
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.05544494
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.94605104
7Histidine metabolism_Homo sapiens_hsa003402.92235007
8Proteasome_Homo sapiens_hsa030502.76203109
9Staphylococcus aureus infection_Homo sapiens_hsa051502.64765431
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.62478034
11Basal transcription factors_Homo sapiens_hsa030222.49257034
12Graft-versus-host disease_Homo sapiens_hsa053322.44320529
13Complement and coagulation cascades_Homo sapiens_hsa046102.43215205
14Pyruvate metabolism_Homo sapiens_hsa006202.40044398
15beta-Alanine metabolism_Homo sapiens_hsa004102.31490406
16Fatty acid metabolism_Homo sapiens_hsa012122.28292435
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.20034276
18Tyrosine metabolism_Homo sapiens_hsa003502.18545272
19Mismatch repair_Homo sapiens_hsa034302.17812872
20Caffeine metabolism_Homo sapiens_hsa002322.06723752
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.04359304
22Chemical carcinogenesis_Homo sapiens_hsa052041.99613454
23* Wnt signaling pathway_Homo sapiens_hsa043101.97759588
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94626977
25Ovarian steroidogenesis_Homo sapiens_hsa049131.94346470
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92046445
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.89983523
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.88599068
29Autoimmune thyroid disease_Homo sapiens_hsa053201.78090883
30TGF-beta signaling pathway_Homo sapiens_hsa043501.71848170
31Homologous recombination_Homo sapiens_hsa034401.68458174
32Linoleic acid metabolism_Homo sapiens_hsa005911.64054720
33Allograft rejection_Homo sapiens_hsa053301.53346237
34Retinol metabolism_Homo sapiens_hsa008301.50434033
35Tryptophan metabolism_Homo sapiens_hsa003801.49997273
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45284310
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.44948043
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44622631
39Arginine biosynthesis_Homo sapiens_hsa002201.44421395
40Fanconi anemia pathway_Homo sapiens_hsa034601.43347216
41Non-homologous end-joining_Homo sapiens_hsa034501.42510891
42Hedgehog signaling pathway_Homo sapiens_hsa043401.39944933
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.37846574
44Steroid biosynthesis_Homo sapiens_hsa001001.36459009
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31222040
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.30491984
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29926703
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27965922
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.27573332
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.27079540
51RNA degradation_Homo sapiens_hsa030181.25529741
52NF-kappa B signaling pathway_Homo sapiens_hsa040641.24554060
53Hippo signaling pathway_Homo sapiens_hsa043901.23208533
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.23015426
55N-Glycan biosynthesis_Homo sapiens_hsa005101.22185307
56Peroxisome_Homo sapiens_hsa041461.18725482
57Olfactory transduction_Homo sapiens_hsa047401.16767160
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15314335
59Leishmaniasis_Homo sapiens_hsa051401.15110110
60Arachidonic acid metabolism_Homo sapiens_hsa005901.13538706
61Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10645051
62Fatty acid degradation_Homo sapiens_hsa000711.06306565
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05353548
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05287186
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05037616
66Rheumatoid arthritis_Homo sapiens_hsa053231.01357765
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00968151
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.99951410
69Cell cycle_Homo sapiens_hsa041100.98481807
70Ether lipid metabolism_Homo sapiens_hsa005650.96936386
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96624219
72RNA transport_Homo sapiens_hsa030130.95200297
73Starch and sucrose metabolism_Homo sapiens_hsa005000.95029330
74Phototransduction_Homo sapiens_hsa047440.94280249
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88212646
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.88144317
77Bile secretion_Homo sapiens_hsa049760.87841835
78Vitamin B6 metabolism_Homo sapiens_hsa007500.85791886
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84466803
80Carbon metabolism_Homo sapiens_hsa012000.84375302
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83191690
82Malaria_Homo sapiens_hsa051440.77123260
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76683405
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75910260
85Pertussis_Homo sapiens_hsa051330.75016907
86PPAR signaling pathway_Homo sapiens_hsa033200.71313567
87Vitamin digestion and absorption_Homo sapiens_hsa049770.71256386
88Chemokine signaling pathway_Homo sapiens_hsa040620.70139057
89Colorectal cancer_Homo sapiens_hsa052100.69699474
90Nitrogen metabolism_Homo sapiens_hsa009100.69212463
91Legionellosis_Homo sapiens_hsa051340.69185035
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68970861
93Measles_Homo sapiens_hsa051620.68132533
94Amoebiasis_Homo sapiens_hsa051460.67215087
95African trypanosomiasis_Homo sapiens_hsa051430.66513163
96Basal cell carcinoma_Homo sapiens_hsa052170.65917210
97Nucleotide excision repair_Homo sapiens_hsa034200.65583941
98Tuberculosis_Homo sapiens_hsa051520.64717611
99Serotonergic synapse_Homo sapiens_hsa047260.62609207
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60562867
101Sulfur metabolism_Homo sapiens_hsa009200.58379020
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.57614885
103ABC transporters_Homo sapiens_hsa020100.56739276
104Asthma_Homo sapiens_hsa053100.54977019
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54463281
106Biosynthesis of amino acids_Homo sapiens_hsa012300.54077871
107Base excision repair_Homo sapiens_hsa034100.52822353
108Propanoate metabolism_Homo sapiens_hsa006400.52068078
109Hematopoietic cell lineage_Homo sapiens_hsa046400.51765612
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51663756
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51410379
112Type I diabetes mellitus_Homo sapiens_hsa049400.50610604
113One carbon pool by folate_Homo sapiens_hsa006700.49617695
114Osteoclast differentiation_Homo sapiens_hsa043800.49258125
115Arginine and proline metabolism_Homo sapiens_hsa003300.49200711
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48755334
117Prion diseases_Homo sapiens_hsa050200.45790850
118Galactose metabolism_Homo sapiens_hsa000520.44985721
119Oocyte meiosis_Homo sapiens_hsa041140.44708191
120Glutathione metabolism_Homo sapiens_hsa004800.44471648
121Folate biosynthesis_Homo sapiens_hsa007900.44024915
122Parkinsons disease_Homo sapiens_hsa050120.43996353
123Metabolic pathways_Homo sapiens_hsa011000.42851356
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42564441
125ECM-receptor interaction_Homo sapiens_hsa045120.42306370
126Glutamatergic synapse_Homo sapiens_hsa047240.41945409
127p53 signaling pathway_Homo sapiens_hsa041150.41851972
128Butanoate metabolism_Homo sapiens_hsa006500.41771446
129Protein digestion and absorption_Homo sapiens_hsa049740.41265847
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40980303
131Primary immunodeficiency_Homo sapiens_hsa053400.40913704
132Platelet activation_Homo sapiens_hsa046110.38855581
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37171136
134TNF signaling pathway_Homo sapiens_hsa046680.37118416
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35318057
136Phagosome_Homo sapiens_hsa041450.33586241
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33506468
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33275704
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31945616
140Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31498172
141Hepatitis C_Homo sapiens_hsa051600.31182761
142Fatty acid elongation_Homo sapiens_hsa000620.29554631
143Proteoglycans in cancer_Homo sapiens_hsa052050.28181015
144Lysine degradation_Homo sapiens_hsa003100.27797259
145Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.26916048
146Maturity onset diabetes of the young_Homo sapiens_hsa049500.26615353
147Sphingolipid metabolism_Homo sapiens_hsa006000.26559210
148Salivary secretion_Homo sapiens_hsa049700.26016880
149cAMP signaling pathway_Homo sapiens_hsa040240.25986023
150Collecting duct acid secretion_Homo sapiens_hsa049660.24519161
151Thyroid hormone synthesis_Homo sapiens_hsa049180.23725312
152Huntingtons disease_Homo sapiens_hsa050160.22564455
153Melanogenesis_Homo sapiens_hsa049160.22243476
154Central carbon metabolism in cancer_Homo sapiens_hsa052300.22211712
155DNA replication_Homo sapiens_hsa030300.21467862
156Fat digestion and absorption_Homo sapiens_hsa049750.19991277
157Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19573758
158Nicotine addiction_Homo sapiens_hsa050330.16675571
159Adherens junction_Homo sapiens_hsa045200.16565343
160Oxidative phosphorylation_Homo sapiens_hsa001900.14424403
161mRNA surveillance pathway_Homo sapiens_hsa030150.13890557
162Calcium signaling pathway_Homo sapiens_hsa040200.12181892

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