DKKL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.88438207
2multicellular organism reproduction (GO:0032504)9.78074764
3plasma membrane fusion (GO:0045026)9.62497178
4epithelial cilium movement (GO:0003351)9.40840789
5spermatid development (GO:0007286)9.30462308
6piRNA metabolic process (GO:0034587)8.97431519
7motile cilium assembly (GO:0044458)8.90312901
8reproduction (GO:0000003)8.16257586
9male meiosis (GO:0007140)7.95076797
10regulation of cilium movement (GO:0003352)7.95048061
11cilium movement (GO:0003341)7.90234488
12synaptonemal complex organization (GO:0070193)7.78867980
13synaptonemal complex assembly (GO:0007130)7.61063340
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.58594490
15single fertilization (GO:0007338)6.84592331
16sperm capacitation (GO:0048240)6.68303016
17spermatogenesis (GO:0007283)6.11778728
18male gamete generation (GO:0048232)6.09846376
19negative regulation of inclusion body assembly (GO:0090084)6.07517244
20fertilization (GO:0009566)5.97534012
21male meiosis I (GO:0007141)5.89765815
22organic cation transport (GO:0015695)5.81602563
23response to pheromone (GO:0019236)5.77578413
24DNA methylation involved in gamete generation (GO:0043046)5.72186453
25gamete generation (GO:0007276)5.60010906
26seminiferous tubule development (GO:0072520)5.49824385
27cellular process involved in reproduction in multicellular organism (GO:0022412)5.30331748
28germ cell development (GO:0007281)5.27815769
29chromosome organization involved in meiosis (GO:0070192)5.24863842
30regulation of inclusion body assembly (GO:0090083)5.24164997
31microtubule depolymerization (GO:0007019)5.13780982
32meiotic nuclear division (GO:0007126)4.99109653
33ventricular system development (GO:0021591)4.91704460
34meiosis I (GO:0007127)4.88805569
35microtubule polymerization or depolymerization (GO:0031109)4.86913112
36calcium ion-dependent exocytosis (GO:0017156)4.86065161
37microtubule severing (GO:0051013)4.66876323
38axon extension involved in axon guidance (GO:0048846)4.66019724
39neuron projection extension involved in neuron projection guidance (GO:1902284)4.66019724
40cell recognition (GO:0008037)4.54694247
41regulation of microtubule-based movement (GO:0060632)4.50040123
42interferon-gamma secretion (GO:0072643)4.47626498
43multicellular organismal reproductive process (GO:0048609)4.36677983
44protein localization to cilium (GO:0061512)4.28957191
45DNA packaging (GO:0006323)4.23243436
46meiotic cell cycle (GO:0051321)4.16982004
47chromosome condensation (GO:0030261)4.16875701
48detection of light stimulus involved in visual perception (GO:0050908)4.13300496
49detection of light stimulus involved in sensory perception (GO:0050962)4.13300496
50ganglion development (GO:0061548)4.12999963
51sequestering of actin monomers (GO:0042989)4.07637668
52left/right pattern formation (GO:0060972)3.99413672
53nonmotile primary cilium assembly (GO:0035058)3.98602179
54male sex determination (GO:0030238)3.96182226
55negative regulation of axon guidance (GO:1902668)3.86923628
56establishment of protein localization to Golgi (GO:0072600)3.86648663
57protein polyglutamylation (GO:0018095)3.85550011
58spermatid nucleus differentiation (GO:0007289)3.83648975
59dorsal/ventral axis specification (GO:0009950)3.82983710
60ectoderm development (GO:0007398)3.73477274
61protein targeting to Golgi (GO:0000042)3.73366688
62receptor recycling (GO:0001881)3.71676223
63protein heterotetramerization (GO:0051290)3.68141111
64glycerol ether metabolic process (GO:0006662)3.66530654
65monoubiquitinated protein deubiquitination (GO:0035520)3.66425692
66negative regulation of axon extension involved in axon guidance (GO:0048843)3.63490444
67rRNA methylation (GO:0031167)3.61197337
68genitalia morphogenesis (GO:0035112)3.60642979
69cerebral cortex neuron differentiation (GO:0021895)3.60057899
70multicellular organismal development (GO:0007275)3.58882748
71calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.56388412
72chaperone-mediated protein complex assembly (GO:0051131)3.46150441
73retrograde transport, vesicle recycling within Golgi (GO:0000301)3.44097873
74rRNA modification (GO:0000154)3.41632193
75ether metabolic process (GO:0018904)3.37833912
76regulation of chromatin binding (GO:0035561)3.34957946
77phosphatidylethanolamine biosynthetic process (GO:0006646)3.34477594
78protein refolding (GO:0042026)3.30041782
79retinal rod cell development (GO:0046548)3.29811911
80axoneme assembly (GO:0035082)3.29125507
81intraciliary transport (GO:0042073)3.27818721
82carnitine transport (GO:0015879)3.27581561
83amino-acid betaine transport (GO:0015838)3.27581561
84meiotic cell cycle process (GO:1903046)3.26593635
85gene silencing by RNA (GO:0031047)3.24224078
86carnitine transmembrane transport (GO:1902603)3.22161090
87regulation of spindle checkpoint (GO:0090231)3.21950731
88phosphatidylethanolamine metabolic process (GO:0046337)3.19428195
89polyamine biosynthetic process (GO:0006596)3.16217581
90protein localization to Golgi apparatus (GO:0034067)3.12525522
91arginine catabolic process (GO:0006527)3.10568283
92synapsis (GO:0007129)3.06818600
93nucleoside diphosphate phosphorylation (GO:0006165)3.05302851
94negative regulation of organelle assembly (GO:1902116)3.04772573
95cell proliferation in forebrain (GO:0021846)3.03143367
96alditol metabolic process (GO:0019400)2.95324211
97single strand break repair (GO:0000012)2.94300031
98nucleus organization (GO:0006997)2.89065202
99positive regulation of Rab GTPase activity (GO:0032851)2.84729852
100regulation of Rab GTPase activity (GO:0032313)2.84729852
101microtubule-based movement (GO:0007018)2.82000255
102GTP biosynthetic process (GO:0006183)2.81585075
103cilium organization (GO:0044782)2.78731181
104cellular ketone body metabolic process (GO:0046950)2.78590536
105polyol catabolic process (GO:0046174)2.77749505
106mitotic sister chromatid cohesion (GO:0007064)2.76082828
107regulation of meiosis I (GO:0060631)2.74904638
108pyrimidine nucleobase catabolic process (GO:0006208)2.73939307
109amine biosynthetic process (GO:0009309)2.72878047
110cilium morphogenesis (GO:0060271)2.72361148
111regulation of centriole replication (GO:0046599)2.71476517
112cranial nerve morphogenesis (GO:0021602)2.70554318
113regulation of transcription involved in cell fate commitment (GO:0060850)2.66176316
114facial nerve structural organization (GO:0021612)2.65424340
115DNA deamination (GO:0045006)2.65008856
116cellular biogenic amine biosynthetic process (GO:0042401)2.64923468
117protein K11-linked deubiquitination (GO:0035871)2.64017737
118establishment of protein localization to mitochondrial membrane (GO:0090151)2.63168324
119cilium assembly (GO:0042384)2.62347514
120histone exchange (GO:0043486)2.61578404
121cochlea morphogenesis (GO:0090103)2.60816319
122sensory perception of smell (GO:0007608)2.60700477
123RNA localization (GO:0006403)2.56367618
124Leydig cell differentiation (GO:0033327)2.56332556
125embryonic eye morphogenesis (GO:0048048)2.55364139
126positive regulation of macrophage activation (GO:0043032)2.55351966
127protein-DNA complex disassembly (GO:0032986)2.54973739
128nucleosome disassembly (GO:0006337)2.54973739
129centriole assembly (GO:0098534)2.54632260
130cellular component assembly involved in morphogenesis (GO:0010927)2.53682082
131brain morphogenesis (GO:0048854)2.53383792
132transmission of nerve impulse (GO:0019226)2.52333854
133centriole replication (GO:0007099)2.51530529
134RNA destabilization (GO:0050779)2.50920371
135regulation of cilium assembly (GO:1902017)2.50642340
136sexual reproduction (GO:0019953)2.49897461
137gene silencing (GO:0016458)2.49464848
138left/right axis specification (GO:0070986)2.48012796
139fusion of sperm to egg plasma membrane (GO:0007342)12.6009873
140sperm motility (GO:0030317)12.0878461
141cilium or flagellum-dependent cell motility (GO:0001539)11.8233262
142cell wall macromolecule catabolic process (GO:0016998)11.2098812
143cell wall macromolecule metabolic process (GO:0044036)11.2098812
144sperm-egg recognition (GO:0035036)11.0373884
145acrosome reaction (GO:0007340)10.7457752
146acrosome assembly (GO:0001675)10.7182045
147binding of sperm to zona pellucida (GO:0007339)10.2771394
148axonemal dynein complex assembly (GO:0070286)10.0154559

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.53668348
2EZH2_22144423_ChIP-Seq_EOC_Human4.00766429
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.29547082
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.64832588
5* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.55123080
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.47508158
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.36941265
8FUS_26573619_Chip-Seq_HEK293_Human2.36135168
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.28099025
10GATA1_26923725_Chip-Seq_HPCs_Mouse2.13963586
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.07615086
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.07169214
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05269741
14* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.7797388
15CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98206875
16TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95656498
17POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.95656498
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.89346187
19* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89221675
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.89168642
21ZNF274_21170338_ChIP-Seq_K562_Hela1.82492725
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.82216441
23TP63_19390658_ChIP-ChIP_HaCaT_Human1.78660863
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.78189852
25FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71683446
26GATA3_21867929_ChIP-Seq_CD8_Mouse1.69615478
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68537807
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67442481
29RNF2_27304074_Chip-Seq_NSC_Mouse1.65631297
30GBX2_23144817_ChIP-Seq_PC3_Human1.60343839
31STAT1_17558387_ChIP-Seq_HELA_Human1.59912573
32SOX2_22085726_ChIP-Seq_NPCs_Mouse1.59489139
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59193524
34ELK4_26923725_Chip-Seq_MESODERM_Mouse1.59111607
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58854835
36VDR_22108803_ChIP-Seq_LS180_Human1.57703632
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.55275804
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.55117505
39ERA_21632823_ChIP-Seq_H3396_Human1.54260648
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.54152302
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52208714
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52106824
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50098066
44P300_19829295_ChIP-Seq_ESCs_Human1.47578989
45AUTS2_25519132_ChIP-Seq_293T-REX_Human1.43714203
46KAP1_22055183_ChIP-Seq_ESCs_Mouse1.43121568
47FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.41226860
48WDR5_24793694_ChIP-Seq_LNCAP_Human1.39080957
49SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.38753490
50P53_21459846_ChIP-Seq_SAOS-2_Human1.38738172
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37830886
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37722425
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37184564
54YY1_22570637_ChIP-Seq_MALME-3M_Human1.36874333
55TAF15_26573619_Chip-Seq_HEK293_Human1.36564720
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35590219
57CTCF_27219007_Chip-Seq_Bcells_Human1.34363995
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.32947777
59PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32937232
60TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.31936511
61E2F1_17053090_ChIP-ChIP_MCF-7_Human1.31275973
62GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.30844596
63KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29564065
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.29173789
65MYC_19829295_ChIP-Seq_ESCs_Human1.27304923
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.26457965
67GATA3_21867929_ChIP-Seq_TH1_Mouse1.26049008
68SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26004892
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25723228
70EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25723228
71AR_25329375_ChIP-Seq_VCAP_Human1.25048414
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.24949777
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24832739
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24811334
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24735867
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23804118
77JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23708609
78ERG_20517297_ChIP-Seq_VCAP_Human1.23517762
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22668749
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22531811
81CBP_20019798_ChIP-Seq_JUKART_Human1.22531811
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22010633
83RAD21_21589869_ChIP-Seq_MESCs_Mouse1.21421059
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.21139924
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20653498
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20650705
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20427399
88LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19984655
89* GATA3_21878914_ChIP-Seq_MCF-7_Human1.19705856
90SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19578340
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19504171
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.18949540
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18547952
94IRF1_19129219_ChIP-ChIP_H3396_Human1.17529435
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.17020898
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.16443304
97SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16274140
98LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.15877413
99LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.15058673
100SMAD3_21741376_ChIP-Seq_ESCs_Human1.14516572
101CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14163455
102EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13514637
103RUNX2_22187159_ChIP-Seq_PCA_Human1.11199008
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11114512
105CTCF_20526341_ChIP-Seq_ESCs_Human1.10537828
106RARA_24833708_ChIP-Seq_LIVER_Mouse1.09590705
107ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08081685
108CTCF_26484167_Chip-Seq_Bcells_Mouse1.07905468
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.07463302
110IGF1R_20145208_ChIP-Seq_DFB_Human1.07289982
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06582596
112FLI1_21867929_ChIP-Seq_CD8_Mouse1.06448376
113SPI1_26923725_Chip-Seq_HPCs_Mouse1.06410116
114* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06192847
115FOXH1_21741376_ChIP-Seq_EPCs_Human1.05927321
116PHF8_20622854_ChIP-Seq_HELA_Human1.05903578
117TAF2_19829295_ChIP-Seq_ESCs_Human1.05243946
118SOX2_19829295_ChIP-Seq_ESCs_Human1.04607299
119NANOG_19829295_ChIP-Seq_ESCs_Human1.04607299
120BCOR_27268052_Chip-Seq_Bcells_Human1.02812845
121BCL6_27268052_Chip-Seq_Bcells_Human1.02297605
122RUNX1_26923725_Chip-Seq_HPCs_Mouse1.02036960
123LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01974374
124MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01940386
125CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.01865239
126RNF2_27304074_Chip-Seq_ESCs_Mouse1.01721782
127CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01506768
128RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01437706
129EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01195273
130PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01109328
131ER_23166858_ChIP-Seq_MCF-7_Human1.00890817
132CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00412591
133* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00265983
134TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99959031
135EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99824627
136SOX2_21211035_ChIP-Seq_LN229_Human0.99822931
137RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99785338
138SMAD4_21799915_ChIP-Seq_A2780_Human0.99105013
139RXR_22108803_ChIP-Seq_LS180_Human0.99050717
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98708041
141ESET_19884257_ChIP-Seq_ESCs_Mouse0.98655203
142NANOG_20526341_ChIP-Seq_ESCs_Human0.98246087
143SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98098071
144GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97855906
145ZNF263_19887448_ChIP-Seq_K562_Human0.97724500
146KDM2B_26808549_Chip-Seq_REH_Human0.97548175
147FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96063888
148FOXA1_25329375_ChIP-Seq_VCAP_Human0.96063888
149CBX2_22325352_ChIP-Seq_293T-Rex_Human0.95485903
150PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95246408
151RAC3_21632823_ChIP-Seq_H3396_Human0.94737328
152SOX11_22085726_ChIP-Seq_ESNs_Mouse0.93830744
153HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92990563
154CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92977367
155GF1_26923725_Chip-Seq_HPCs_Mouse0.92316738
156MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91596579
157GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91578323
158MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91571230
159NFYB_21822215_ChIP-Seq_K562_Human0.91264200
160PHF8_20622853_ChIP-Seq_HELA_Human0.91119601
161GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91034515
162HNFA_21074721_ChIP-Seq_CACO-2_Human0.90660561
163MYC_18940864_ChIP-ChIP_HL60_Human0.89995449
164RBPJ_21746931_ChIP-Seq_IB4_Human0.89858185
165FLI1_21867929_ChIP-Seq_TH2_Mouse0.88964102
166HOXB7_26014856_ChIP-Seq_BT474_Human0.88903136
167REST_21632747_ChIP-Seq_MESCs_Mouse0.88482798
168RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88394989
169CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88187102
170* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88010038
171MYC_27129775_Chip-Seq_CORNEA_Mouse0.87990722
172SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85650170
173CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84422749
174STAT1_20625510_ChIP-Seq_HELA_Human0.84099879
175RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84005825
176PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83637905

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.87396937
2* MP0001929_abnormal_gametogenesis5.48817506
3MP0008877_abnormal_DNA_methylation4.64296096
4MP0008789_abnormal_olfactory_epithelium4.12121950
5MP0002210_abnormal_sex_determination3.70518705
6MP0005499_abnormal_olfactory_system3.64160625
7MP0005394_taste/olfaction_phenotype3.64160625
8MP0002161_abnormal_fertility/fecundity3.19280589
9MP0006292_abnormal_olfactory_placode3.19279361
10* MP0001145_abnormal_male_reproductive3.09962094
11MP0003880_abnormal_central_pattern2.75227880
12MP0002163_abnormal_gland_morphology2.71038783
13* MP0000653_abnormal_sex_gland2.67400767
14MP0002160_abnormal_reproductive_system2.64613267
15MP0002653_abnormal_ependyma_morphology2.37060305
16MP0005645_abnormal_hypothalamus_physiol2.36939921
17MP0010030_abnormal_orbit_morphology2.33251330
18MP0005379_endocrine/exocrine_gland_phen2.28895328
19MP0000778_abnormal_nervous_system2.20494237
20* MP0005410_abnormal_fertilization14.9911385
21MP0000566_synostosis1.96987104
22MP0005670_abnormal_white_adipose1.88986200
23MP0003646_muscle_fatigue1.84506346
24MP0005551_abnormal_eye_electrophysiolog1.78459118
25MP0006276_abnormal_autonomic_nervous1.77541603
26MP0005248_abnormal_Harderian_gland1.73400540
27MP0001542_abnormal_bone_strength1.57176205
28MP0008058_abnormal_DNA_repair1.53235552
29MP0001529_abnormal_vocalization1.52929450
30MP0002796_impaired_skin_barrier1.50008129
31MP0002233_abnormal_nose_morphology1.49434460
32MP0003136_yellow_coat_color1.45075990
33MP0000049_abnormal_middle_ear1.41031855
34MP0005389_reproductive_system_phenotype1.40459726
35MP0005623_abnormal_meninges_morphology1.40261824
36MP0002184_abnormal_innervation1.35522011
37MP0003122_maternal_imprinting1.31719291
38MP0003718_maternal_effect1.30505944
39MP0002938_white_spotting1.29001867
40MP0005084_abnormal_gallbladder_morpholo1.27069759
41MP0001486_abnormal_startle_reflex1.26841769
42MP0001545_abnormal_hematopoietic_system1.26828259
43MP0005397_hematopoietic_system_phenotyp1.26828259
44MP0002822_catalepsy1.26464814
45MP0010094_abnormal_chromosome_stability1.26228826
46MP0000026_abnormal_inner_ear1.25445353
47MP0005423_abnormal_somatic_nervous1.25101724
48MP0004233_abnormal_muscle_weight1.22625411
49MP0002752_abnormal_somatic_nervous1.17112813
50MP0009053_abnormal_anal_canal1.13477987
51MP0003121_genomic_imprinting1.10572032
52MP0002557_abnormal_social/conspecific_i1.10258626
53MP0001286_abnormal_eye_development1.09205845
54MP0004808_abnormal_hematopoietic_stem1.08956822
55MP0000534_abnormal_ureter_morphology1.07262514
56MP0005195_abnormal_posterior_eye1.07054740
57MP0005253_abnormal_eye_physiology1.06177096
58MP0008057_abnormal_DNA_replication1.06037689
59MP0002272_abnormal_nervous_system1.03633201
60MP0005083_abnormal_biliary_tract1.03437331
61MP0008007_abnormal_cellular_replicative1.03422777
62MP0003111_abnormal_nucleus_morphology1.03163968
63MP0005646_abnormal_pituitary_gland1.02678965
64MP0001765_abnormal_ion_homeostasis1.02478753
65MP0001984_abnormal_olfaction1.00915097
66MP0002735_abnormal_chemical_nociception1.00797958
67MP0003119_abnormal_digestive_system1.00349338
68MP0003861_abnormal_nervous_system1.00300018
69MP0002882_abnormal_neuron_morphology0.99237680
70MP0000631_abnormal_neuroendocrine_gland0.98806549
71MP0001963_abnormal_hearing_physiology0.98209547
72MP0002697_abnormal_eye_size0.97994650
73MP0001968_abnormal_touch/_nociception0.96811067
74MP0002249_abnormal_larynx_morphology0.94583136
75MP0005395_other_phenotype0.92836598
76MP0008995_early_reproductive_senescence0.92832770
77MP0004859_abnormal_synaptic_plasticity0.92316004
78MP0002572_abnormal_emotion/affect_behav0.91978817
79MP0002282_abnormal_trachea_morphology0.90937809
80MP0001346_abnormal_lacrimal_gland0.89894425
81MP0003011_delayed_dark_adaptation0.89190945
82MP0005174_abnormal_tail_pigmentation0.87485793
83MP0001485_abnormal_pinna_reflex0.86698317
84MP0003693_abnormal_embryo_hatching0.86564922
85MP0005075_abnormal_melanosome_morpholog0.85811495
86MP0003786_premature_aging0.85277609
87MP0004142_abnormal_muscle_tone0.85248638
88MP0005391_vision/eye_phenotype0.84987333
89MP0003937_abnormal_limbs/digits/tail_de0.84451982
90MP0000955_abnormal_spinal_cord0.82863296
91MP0003942_abnormal_urinary_system0.82715079
92MP0002734_abnormal_mechanical_nocicepti0.82219529
93MP0005171_absent_coat_pigmentation0.81803633
94MP0001348_abnormal_lacrimal_gland0.80287975
95MP0005501_abnormal_skin_physiology0.80194587
96MP0006036_abnormal_mitochondrial_physio0.79855576
97MP0000358_abnormal_cell_content/0.79131779
98MP0006072_abnormal_retinal_apoptosis0.78592036
99MP0003938_abnormal_ear_development0.77960217
100MP0004811_abnormal_neuron_physiology0.77726959
101MP0002234_abnormal_pharynx_morphology0.77672119
102MP0005647_abnormal_sex_gland0.77578131
103MP0009250_abnormal_appendicular_skeleto0.76975339
104MP0004133_heterotaxia0.76553699
105MP0000516_abnormal_urinary_system0.74685789
106MP0005367_renal/urinary_system_phenotyp0.74685789
107MP0003635_abnormal_synaptic_transmissio0.74001498
108MP0009046_muscle_twitch0.73558350
109MP0002168_other_aberrant_phenotype0.72937178
110MP0000579_abnormal_nail_morphology0.72711936
111MP0001905_abnormal_dopamine_level0.72048658
112MP0002152_abnormal_brain_morphology0.72018075
113MP0003755_abnormal_palate_morphology0.71127878
114MP0004742_abnormal_vestibular_system0.69831661
115MP0004957_abnormal_blastocyst_morpholog0.69325228
116MP0003077_abnormal_cell_cycle0.66585006
117MP0010234_abnormal_vibrissa_follicle0.66455341
118MP0005636_abnormal_mineral_homeostasis0.64610613
119MP0009278_abnormal_bone_marrow0.63305884
120MP0003879_abnormal_hair_cell0.59030049
121MP0000685_abnormal_immune_system0.55899553
122MP0003878_abnormal_ear_physiology0.52724094
123MP0005377_hearing/vestibular/ear_phenot0.52724094
124MP0003699_abnormal_female_reproductive0.52514434
125MP0003763_abnormal_thymus_physiology0.52316089
126MP0003183_abnormal_peptide_metabolism0.51980028
127MP0000313_abnormal_cell_death0.51525552
128MP0004264_abnormal_extraembryonic_tissu0.49818596
129MP0001764_abnormal_homeostasis0.47616144
130MP0004381_abnormal_hair_follicle0.46792767
131MP0002009_preneoplasia0.45260826
132MP0006035_abnormal_mitochondrial_morpho0.44858046
133MP0002398_abnormal_bone_marrow0.43632422
134MP0000015_abnormal_ear_pigmentation0.43342103
135MP0003115_abnormal_respiratory_system0.43205940
136MP0001986_abnormal_taste_sensitivity0.42299108
137MP0001216_abnormal_epidermal_layer0.42243932
138MP0003315_abnormal_perineum_morphology0.42066423
139MP0001873_stomach_inflammation0.42045589
140MP0004019_abnormal_vitamin_homeostasis0.41373272
141MP0005451_abnormal_body_composition0.40051118
142MP0001324_abnormal_eye_pigmentation0.39380877
143MP0001730_embryonic_growth_arrest0.39187351
144MP0001119_abnormal_female_reproductive0.38542370
145MP0000703_abnormal_thymus_morphology0.37461173
146MP0002132_abnormal_respiratory_system0.37355888
147MP0002405_respiratory_system_inflammati0.35880913
148MP0002095_abnormal_skin_pigmentation0.35632865
149MP0001727_abnormal_embryo_implantation0.35466821
150MP0009931_abnormal_skin_appearance0.35298405
151MP0003943_abnormal_hepatobiliary_system0.35213448
152MP0004947_skin_inflammation0.34038785
153MP0003866_abnormal_defecation0.33989194
154MP0001293_anophthalmia0.33415140
155MP0000689_abnormal_spleen_morphology0.31570683
156MP0000427_abnormal_hair_cycle0.30695643
157MP0004036_abnormal_muscle_relaxation0.30665243
158MP0001851_eye_inflammation0.29520817
159MP0001835_abnormal_antigen_presentation0.29025829
160MP0002019_abnormal_tumor_incidence0.28642740
161MP0002169_no_abnormal_phenotype0.27750493
162MP0002873_normal_phenotype0.27603792
163MP0005666_abnormal_adipose_tissue0.27577888
164MP0009785_altered_susceptibility_to0.27382848
165MP0000490_abnormal_crypts_of0.27142588
166MP0005464_abnormal_platelet_physiology0.26152420
167MP0002722_abnormal_immune_system0.25849867
168MP0003329_amyloid_beta_deposits0.25425718
169MP0003950_abnormal_plasma_membrane0.25310828
170MP0003941_abnormal_skin_development0.25286285
171MP0002723_abnormal_immune_serum0.25112822
172MP0002429_abnormal_blood_cell0.25014875
173MP0003936_abnormal_reproductive_system0.24913571
174MP0001697_abnormal_embryo_size0.24632757
175MP0002080_prenatal_lethality0.24194666

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.89889801
2Abnormal respiratory epithelium morphology (HP:0012253)8.55539121
3Abnormal respiratory motile cilium morphology (HP:0005938)8.55539121
4Rhinitis (HP:0012384)7.96194558
5Chronic bronchitis (HP:0004469)7.32676959
6Abnormal ciliary motility (HP:0012262)6.77376067
7Nasal polyposis (HP:0100582)6.70065556
8Infertility (HP:0000789)6.60645782
9Abnormality of the nasal mucosa (HP:0000433)5.61507729
10Bronchitis (HP:0012387)4.85248450
11Bony spicule pigmentary retinopathy (HP:0007737)4.83018894
12Bronchiectasis (HP:0002110)4.76722044
13Nephronophthisis (HP:0000090)4.72622637
14Sex reversal (HP:0012245)4.08453923
15Abnormal sex determination (HP:0012244)4.08453923
16Rib fusion (HP:0000902)3.72317745
17Severe visual impairment (HP:0001141)3.62181033
18Abnormal spermatogenesis (HP:0008669)3.57143510
19Abnormality of the renal medulla (HP:0100957)3.50451098
20True hermaphroditism (HP:0010459)3.45801654
21Recurrent otitis media (HP:0000403)3.43792499
22Hypoplasia of the uterus (HP:0000013)3.37705418
23Attenuation of retinal blood vessels (HP:0007843)3.33744438
24Gonadotropin excess (HP:0000837)3.32968526
25Abnormal rod and cone electroretinograms (HP:0008323)3.32797374
26Male infertility (HP:0003251)3.27800157
27Recurrent sinusitis (HP:0011108)3.24331087
28Osteomalacia (HP:0002749)3.24080954
29Recurrent bronchitis (HP:0002837)3.20296110
30Gait imbalance (HP:0002141)3.00561524
31Congenital primary aphakia (HP:0007707)2.97468878
32Molar tooth sign on MRI (HP:0002419)2.94279745
33Abnormality of midbrain morphology (HP:0002418)2.94279745
34Abnormality of the labia minora (HP:0012880)2.93196574
35Concave nail (HP:0001598)2.76906558
36Azoospermia (HP:0000027)2.76771291
37Myokymia (HP:0002411)2.74777822
38Sclerocornea (HP:0000647)2.73845145
39Chronic hepatic failure (HP:0100626)2.72806241
40Aplasia/hypoplasia of the uterus (HP:0008684)2.70714957
41Nephrogenic diabetes insipidus (HP:0009806)2.70699931
42Pancreatic cysts (HP:0001737)2.70521549
43Tubulointerstitial nephritis (HP:0001970)2.70377321
44Vaginal atresia (HP:0000148)2.66122054
45Genital tract atresia (HP:0001827)2.63164950
46Progressive cerebellar ataxia (HP:0002073)2.57752242
47Male pseudohermaphroditism (HP:0000037)2.57463917
48Tubular atrophy (HP:0000092)2.55546807
49Aplasia/Hypoplasia of the earlobes (HP:0009906)2.55313328
50Polyphagia (HP:0002591)2.53436353
51Abnormality of the aortic arch (HP:0012303)2.47457432
52Anencephaly (HP:0002323)2.46738542
53Impulsivity (HP:0100710)2.45395402
54Abnormality of macular pigmentation (HP:0008002)2.42613927
55Abnormality of renal resorption (HP:0011038)2.40688990
56Medial flaring of the eyebrow (HP:0010747)2.37017996
57Absent rod-and cone-mediated responses on ERG (HP:0007688)2.31296309
58Tubulointerstitial abnormality (HP:0001969)2.30687001
59Abnormality of the lower motor neuron (HP:0002366)2.26838871
60Amyotrophic lateral sclerosis (HP:0007354)2.21843377
61Poor coordination (HP:0002370)2.21770086
62Occipital encephalocele (HP:0002085)2.17344993
63Hyperglycinemia (HP:0002154)2.17194638
64Short 4th metacarpal (HP:0010044)2.16584056
65Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.16584056
66Renal Fanconi syndrome (HP:0001994)2.14200906
67Postaxial foot polydactyly (HP:0001830)2.11536173
68Preaxial hand polydactyly (HP:0001177)2.09281150
69Cholecystitis (HP:0001082)2.07765069
70Abnormal gallbladder physiology (HP:0012438)2.07765069
71Multicystic kidney dysplasia (HP:0000003)2.03753013
72Hypoplastic ischia (HP:0003175)2.03404131
73Hypoplasia of the capital femoral epiphysis (HP:0003090)2.01577030
74Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0982142
75Absent/shortened dynein arms (HP:0200106)12.0202226
76Dynein arm defect of respiratory motile cilia (HP:0012255)12.0202226
77Bell-shaped thorax (HP:0001591)1.99289161
78Pendular nystagmus (HP:0012043)1.99175805
79Poor suck (HP:0002033)1.98519746
80Holoprosencephaly (HP:0001360)1.96985353
81Abnormal number of incisors (HP:0011064)1.95295938
82High anterior hairline (HP:0009890)1.94080524
83Astigmatism (HP:0000483)1.92411860
84Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.91244705
85Anophthalmia (HP:0000528)1.89762211
86Gonadal dysgenesis (HP:0000133)1.88523239
87Tubulointerstitial fibrosis (HP:0005576)1.88035012
88Aplasia/Hypoplasia of the lens (HP:0008063)1.87190399
89Supernumerary bones of the axial skeleton (HP:0009144)1.86009540
90Renal dysplasia (HP:0000110)1.85438184
91Fibular hypoplasia (HP:0003038)1.84169894
92Optic nerve hypoplasia (HP:0000609)1.83897985
93Spastic tetraparesis (HP:0001285)1.82572835
94Impaired proprioception (HP:0010831)1.81835861
95Aganglionic megacolon (HP:0002251)1.81349095
96Hypoplasia of the brainstem (HP:0002365)1.81289880
97Aplasia/Hypoplasia of the brainstem (HP:0007362)1.81289880
98Abnormality of the ischium (HP:0003174)1.79663268
99Congenital hepatic fibrosis (HP:0002612)1.79538354
100Supernumerary ribs (HP:0005815)1.79229912
101Oculomotor apraxia (HP:0000657)1.77054844
102Hyperthyroidism (HP:0000836)1.75995161
103Hypoplastic pelvis (HP:0008839)1.75939583
104Abnormality of the renal cortex (HP:0011035)1.75676345
105Abnormality of permanent molar morphology (HP:0011071)1.75098766
106Abnormality of the dental root (HP:0006486)1.75098766
107Taurodontia (HP:0000679)1.75098766
108Stage 5 chronic kidney disease (HP:0003774)1.73095806
109Polydipsia (HP:0001959)1.72357837
110Abnormal drinking behavior (HP:0030082)1.72357837
111Enlarged epiphyses (HP:0010580)1.71888115
112Short ribs (HP:0000773)1.69873587
113Abdominal situs inversus (HP:0003363)1.68938413
114Abnormality of abdominal situs (HP:0011620)1.68938413
115Broad foot (HP:0001769)1.67728706
116Increased corneal curvature (HP:0100692)1.66836753
117Keratoconus (HP:0000563)1.66836753
118Chronic sinusitis (HP:0011109)1.66241328
119Abnormality of dental color (HP:0011073)1.65998210
120Trigonocephaly (HP:0000243)1.65567958
121Ectopic kidney (HP:0000086)1.64470474
122Facial cleft (HP:0002006)1.60072270
123Absent frontal sinuses (HP:0002688)1.58395372
124Abnormality of molar morphology (HP:0011070)1.58394596
125Abnormality of molar (HP:0011077)1.58394596
126Abnormality of the dental pulp (HP:0006479)1.57119354
127J-shaped sella turcica (HP:0002680)1.56610787
128Abnormality of renal excretion (HP:0011036)1.55567996
129Cerebellar dysplasia (HP:0007033)1.53885647
130Median cleft lip (HP:0000161)1.53364689
131Absent epiphyses (HP:0010577)1.53182522
132Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.53182522
133Easy fatigability (HP:0003388)1.50104214
13411 pairs of ribs (HP:0000878)1.49938062
135Pancreatic fibrosis (HP:0100732)1.49880783
136Abnormal number of erythroid precursors (HP:0012131)1.48636675
137Supernumerary spleens (HP:0009799)1.47714784
138Postaxial hand polydactyly (HP:0001162)1.47564820
139Heterotopia (HP:0002282)1.47396294
140Loss of speech (HP:0002371)1.47267759
141Bile duct proliferation (HP:0001408)1.47202915
142Abnormal biliary tract physiology (HP:0012439)1.47202915
143Dyschromatopsia (HP:0007641)1.46430891
144Abnormality of cells of the erythroid lineage (HP:0012130)1.46056883
145Microglossia (HP:0000171)1.44308352
146Nephropathy (HP:0000112)1.43560624
147Congenital malformation of the right heart (HP:0011723)1.40598201
148Double outlet right ventricle (HP:0001719)1.40598201
149Abnormality of the anterior horn cell (HP:0006802)1.39986629
150Degeneration of anterior horn cells (HP:0002398)1.39986629
151Deformed sella turcica (HP:0002681)1.39919979
152Type 2 muscle fiber atrophy (HP:0003554)1.38091073
153Choroideremia (HP:0001139)1.34065873
154Abnormality of the neuromuscular junction (HP:0003398)1.33162552
155Fatigable weakness (HP:0003473)1.33162552
156Decreased central vision (HP:0007663)1.29370215
157Short thorax (HP:0010306)1.28585636
158Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.27519374
159Cystic liver disease (HP:0006706)1.25591756
160Abnormality of dentin (HP:0010299)1.24466299
161Short femoral neck (HP:0100864)1.24405620
162Aplasia/Hypoplasia of the tongue (HP:0010295)1.24015549
163Type II lissencephaly (HP:0007260)1.23399909
164Muscle fiber atrophy (HP:0100295)1.22539390
165Abnormality of ocular smooth pursuit (HP:0000617)1.21772642
166Bulbar palsy (HP:0001283)1.19560612
167Glucose intolerance (HP:0000833)1.19472091
168Abnormal urine output (HP:0012590)1.19327738
169Retinal dysplasia (HP:0007973)1.17629039

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.88882356
2PDK47.88882356
3TESK16.87340066
4PDK25.05685245
5PRKD34.03968648
6ICK3.77680918
7MAP4K23.12045904
8MAP3K42.77207135
9PTK2B2.45664977
10INSRR2.42194938
11NEK22.38306814
12EPHA42.37514834
13PLK22.21462102
14FGFR22.15325838
15ZAK2.02126340
16DDR21.99127897
17WNK41.93382853
18PNCK1.93037534
19STK381.86442483
20STK391.86262012
21DYRK21.74955940
22EPHB21.66048175
23WNK31.57844707
24MARK11.57030346
25NUAK11.54286290
26CCNB11.53141653
27TNIK1.51094942
28TRIM281.50428786
29BCR1.48735165
30RPS6KA21.45857929
31VRK21.41341562
32EEF2K1.35346260
33STK38L1.30678078
34DYRK1B1.20364418
35VRK11.15859131
36TIE11.15731772
37WEE11.14476371
38DYRK31.14332662
39MINK11.10472176
40CSNK1G21.07590909
41PDK11.06742181
42MUSK1.04980616
43CSNK1G31.03004087
44BCKDK0.95048316
45MAPKAPK50.94178947
46PBK0.93121218
47RPS6KC10.91881502
48RPS6KL10.91881502
49MAP2K60.91012144
50BRD40.90817457
51CSNK1A1L0.89151448
52RPS6KA60.88154690
53PASK0.87930696
54UHMK10.86026117
55CSNK1G10.85573125
56CDK190.76719598
57MAPK130.73785327
58TTK0.71056545
59MAPK150.70901993
60TYRO30.70751032
61PLK30.68801878
62CDK70.67773877
63GRK10.66969535
64EPHA20.65330974
65PINK10.62208592
66OXSR10.62163148
67MAPKAPK30.61070098
68MAP4K10.60332826
69MKNK10.60111533
70STK30.59376222
71WNK10.58985518
72FGFR10.58355000
73IRAK10.57492141
74CHEK20.56786350
75PDPK10.53039829
76RIPK40.52165863
77CSNK1A10.51782891
78PRKG10.50769591
79TESK20.49374079
80CSF1R0.48639553
81RPS6KA40.48535690
82BUB10.48015956
83PRKACA0.47801647
84ATR0.47435370
85CDC70.47385983
86PRKCE0.46653187
87TAF10.46318913
88PAK30.46178790
89CDK140.45208870
90CDK10.44942891
91CSNK1E0.43681492
92MKNK20.42901532
93CDK11A0.41143737
94ZAP700.40843168
95PLK40.38251573
96PAK10.38183663
97CAMK2A0.38110915
98CHEK10.38102901
99CDK20.37859712
100SGK2230.37849424
101SGK4940.37849424
102MAP2K40.37570001
103STK160.36827104
104MAPK80.35840489
105CDK50.35738249
106SRPK10.35185307
107KIT0.35062155
108MAP3K60.34334828
109CAMK1G0.33045801
110BRSK20.32671473
111RPS6KB20.32477632
112BRAF0.32117933
113CAMKK10.31211217
114GSK3B0.31150783
115PAK40.30126264
116PIM20.26335870
117MAP3K120.26001932
118DAPK10.24856840
119RPS6KB10.24180454
120PLK10.23457763
121ATM0.22845417
122CAMK10.20331294
123MYLK0.19747766
124PIM10.19066023
125CDK30.17221174
126TAOK10.17191159
127PRKCG0.16768287
128DAPK20.16538114
129BMPR1B0.16149951
130MAP2K70.15898424
131MARK20.14770107
132PAK20.14328724
133MAP2K30.13914306
134CSNK2A10.13599811
135MTOR0.13425620
136BTK0.12468160
137NTRK20.11552791
138SYK0.10131417
139NME20.10050079
140CSNK2A20.09437310
141CAMKK20.08138979
142ADRBK20.07968945
143MAP3K50.07819487
144AURKA0.07397463
145PRKG20.07214533
146PRKAA10.07194970
147MAP3K110.06422479
148BRSK10.06086634
149TXK0.05908118
150CASK0.05507610
151PIK3CG0.05197049
152MAP3K30.04867716
153NEK60.04317832
154TBK10.04023976
155RPS6KA10.02609506
156IRAK20.01346342
157DAPK30.01332774
158AKT30.00854845
159MATK0.00712313
160GRK60.00382687
161STK100.00162159

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.97270216
2Phototransduction_Homo sapiens_hsa047444.07200568
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.52160229
4Fatty acid biosynthesis_Homo sapiens_hsa000613.38118833
5Pyruvate metabolism_Homo sapiens_hsa006203.25068977
6Vitamin B6 metabolism_Homo sapiens_hsa007503.20500992
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.15577283
8Linoleic acid metabolism_Homo sapiens_hsa005913.08871189
9Basal transcription factors_Homo sapiens_hsa030222.87533375
10Olfactory transduction_Homo sapiens_hsa047402.57028482
11Steroid biosynthesis_Homo sapiens_hsa001002.43874000
12Fanconi anemia pathway_Homo sapiens_hsa034602.40715055
13Glucagon signaling pathway_Homo sapiens_hsa049222.34313094
14Selenocompound metabolism_Homo sapiens_hsa004502.22077732
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.21173423
16Pentose phosphate pathway_Homo sapiens_hsa000302.14610988
17Propanoate metabolism_Homo sapiens_hsa006402.08872469
18Butanoate metabolism_Homo sapiens_hsa006501.98220524
19Huntingtons disease_Homo sapiens_hsa050161.97237381
20Oocyte meiosis_Homo sapiens_hsa041141.96447729
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88861383
22Fructose and mannose metabolism_Homo sapiens_hsa000511.77845199
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.71733852
24Basal cell carcinoma_Homo sapiens_hsa052171.71296108
25Glycerolipid metabolism_Homo sapiens_hsa005611.70231526
26RNA transport_Homo sapiens_hsa030131.69360878
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.68536634
28Antigen processing and presentation_Homo sapiens_hsa046121.63489355
29DNA replication_Homo sapiens_hsa030301.63120099
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.59629310
31Proteasome_Homo sapiens_hsa030501.58761152
32Amphetamine addiction_Homo sapiens_hsa050311.54438856
33Dorso-ventral axis formation_Homo sapiens_hsa043201.49858365
34mRNA surveillance pathway_Homo sapiens_hsa030151.49027084
35Arachidonic acid metabolism_Homo sapiens_hsa005901.46482083
36Purine metabolism_Homo sapiens_hsa002301.42993774
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42047518
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.40913065
39Ether lipid metabolism_Homo sapiens_hsa005651.36915565
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35996912
41Pyrimidine metabolism_Homo sapiens_hsa002401.28993031
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.28954348
43Phenylalanine metabolism_Homo sapiens_hsa003601.28569105
44Cardiac muscle contraction_Homo sapiens_hsa042601.27151935
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26932670
46Nicotine addiction_Homo sapiens_hsa050331.25170080
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.24998568
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23741531
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.22932785
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21630420
51Ribosome_Homo sapiens_hsa030101.17456430
52Axon guidance_Homo sapiens_hsa043601.17074959
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.14750104
54Protein export_Homo sapiens_hsa030601.13433950
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10039660
56Collecting duct acid secretion_Homo sapiens_hsa049661.07901134
57Fat digestion and absorption_Homo sapiens_hsa049751.07705470
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05834427
59Arginine and proline metabolism_Homo sapiens_hsa003301.05715466
60Glutathione metabolism_Homo sapiens_hsa004801.05419515
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04568169
62Non-homologous end-joining_Homo sapiens_hsa034501.01849740
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01823671
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98437100
65Renin secretion_Homo sapiens_hsa049240.97878593
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.96390361
67PPAR signaling pathway_Homo sapiens_hsa033200.96020343
68Caffeine metabolism_Homo sapiens_hsa002320.93861742
69Carbon metabolism_Homo sapiens_hsa012000.92712645
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92660744
71Nitrogen metabolism_Homo sapiens_hsa009100.90162444
72RNA degradation_Homo sapiens_hsa030180.89931999
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89052898
74Sphingolipid metabolism_Homo sapiens_hsa006000.88219567
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85731925
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84860276
77N-Glycan biosynthesis_Homo sapiens_hsa005100.84754232
78Peroxisome_Homo sapiens_hsa041460.83215994
79Systemic lupus erythematosus_Homo sapiens_hsa053220.80949981
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80656175
81Homologous recombination_Homo sapiens_hsa034400.80542074
82Long-term potentiation_Homo sapiens_hsa047200.80203240
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.79719694
84Base excision repair_Homo sapiens_hsa034100.79147706
85VEGF signaling pathway_Homo sapiens_hsa043700.78364457
86Taste transduction_Homo sapiens_hsa047420.78277587
87Spliceosome_Homo sapiens_hsa030400.74342688
88Morphine addiction_Homo sapiens_hsa050320.73470672
89Fatty acid elongation_Homo sapiens_hsa000620.72461849
90Hippo signaling pathway_Homo sapiens_hsa043900.71103353
91Mismatch repair_Homo sapiens_hsa034300.70387224
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70366474
93Retinol metabolism_Homo sapiens_hsa008300.69961366
94Synaptic vesicle cycle_Homo sapiens_hsa047210.69839291
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69419069
96Circadian entrainment_Homo sapiens_hsa047130.69226945
97Legionellosis_Homo sapiens_hsa051340.68973779
98Wnt signaling pathway_Homo sapiens_hsa043100.66364075
99Arginine biosynthesis_Homo sapiens_hsa002200.66195367
100Nucleotide excision repair_Homo sapiens_hsa034200.65037859
101B cell receptor signaling pathway_Homo sapiens_hsa046620.64833064
102Protein digestion and absorption_Homo sapiens_hsa049740.63393897
103ABC transporters_Homo sapiens_hsa020100.63266440
104Mineral absorption_Homo sapiens_hsa049780.63235398
105Endocytosis_Homo sapiens_hsa041440.62206669
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61165331
107Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58687746
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54792356
109Calcium signaling pathway_Homo sapiens_hsa040200.52530880
110Fatty acid metabolism_Homo sapiens_hsa012120.51753232
111Alcoholism_Homo sapiens_hsa050340.51746592
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.50918319
113Hedgehog signaling pathway_Homo sapiens_hsa043400.50881866
114cAMP signaling pathway_Homo sapiens_hsa040240.50318851
115Cell cycle_Homo sapiens_hsa041100.50242559
116Notch signaling pathway_Homo sapiens_hsa043300.50097673
117Glutamatergic synapse_Homo sapiens_hsa047240.49311067
118Insulin secretion_Homo sapiens_hsa049110.48910058
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.47710503
120Estrogen signaling pathway_Homo sapiens_hsa049150.47086390
121Inositol phosphate metabolism_Homo sapiens_hsa005620.46753371
122Salivary secretion_Homo sapiens_hsa049700.46653777
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46537614
124Epstein-Barr virus infection_Homo sapiens_hsa051690.46166272
125Tryptophan metabolism_Homo sapiens_hsa003800.46115957
126Metabolic pathways_Homo sapiens_hsa011000.45802418
127GABAergic synapse_Homo sapiens_hsa047270.45617231
128RNA polymerase_Homo sapiens_hsa030200.45074473
129Tyrosine metabolism_Homo sapiens_hsa003500.44762076
130AMPK signaling pathway_Homo sapiens_hsa041520.43991817
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43899088
132Oxidative phosphorylation_Homo sapiens_hsa001900.43299032
133Regulation of autophagy_Homo sapiens_hsa041400.40688891
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39783114
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39586029
136Melanogenesis_Homo sapiens_hsa049160.39319635
137Biosynthesis of amino acids_Homo sapiens_hsa012300.37241587
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36935143
139Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36669741
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36330513
141Viral carcinogenesis_Homo sapiens_hsa052030.35645177
142Other glycan degradation_Homo sapiens_hsa005110.35094999
143Serotonergic synapse_Homo sapiens_hsa047260.34900583
144Fatty acid degradation_Homo sapiens_hsa000710.34487468
145Parkinsons disease_Homo sapiens_hsa050120.33674143
146Measles_Homo sapiens_hsa051620.33530926
147Chemical carcinogenesis_Homo sapiens_hsa052040.32954348
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30769860
149T cell receptor signaling pathway_Homo sapiens_hsa046600.30496746
150Herpes simplex infection_Homo sapiens_hsa051680.30230574
151Gastric acid secretion_Homo sapiens_hsa049710.29243851
152Alzheimers disease_Homo sapiens_hsa050100.29230911
153Vascular smooth muscle contraction_Homo sapiens_hsa042700.29164938
154Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28624669
155Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28157166
156Sulfur relay system_Homo sapiens_hsa041220.27497880
157Renin-angiotensin system_Homo sapiens_hsa046140.26614467
158Salmonella infection_Homo sapiens_hsa051320.26461325

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