DLAT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* tricarboxylic acid cycle (GO:0006099)7.54067743
2carnitine shuttle (GO:0006853)6.58073427
3* regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)6.18506542
4fatty acid transmembrane transport (GO:1902001)6.02725059
5* regulation of acyl-CoA biosynthetic process (GO:0050812)5.70827847
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.66907379
7NADH metabolic process (GO:0006734)5.63568109
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.49278953
9* regulation of coenzyme metabolic process (GO:0051196)5.43813200
10* regulation of cofactor metabolic process (GO:0051193)5.43813200
11sarcomere organization (GO:0045214)5.34674981
12nuclear pore complex assembly (GO:0051292)5.31727760
13regulation of sequestering of triglyceride (GO:0010889)5.20335559
14lysine catabolic process (GO:0006554)5.15772638
15lysine metabolic process (GO:0006553)5.15772638
16regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.13795709
17cardiac myofibril assembly (GO:0055003)5.09796027
18carnitine transmembrane transport (GO:1902603)5.07833566
19negative regulation of potassium ion transmembrane transport (GO:1901380)5.03321526
20regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.96170449
21amino-acid betaine transport (GO:0015838)4.86033699
22carnitine transport (GO:0015879)4.86033699
23succinate metabolic process (GO:0006105)4.82893373
24regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.80446033
25nuclear pore organization (GO:0006999)4.74523113
26fatty acid beta-oxidation (GO:0006635)4.72405661
272-oxoglutarate metabolic process (GO:0006103)4.71361311
28DNA unwinding involved in DNA replication (GO:0006268)4.69057617
29regulation of fatty acid oxidation (GO:0046320)4.59029424
30plasma membrane repair (GO:0001778)4.53923891
31mitotic chromosome condensation (GO:0007076)4.51560395
32cardiac muscle contraction (GO:0060048)4.50776681
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.47616022
34aspartate family amino acid catabolic process (GO:0009068)4.46044932
35myofibril assembly (GO:0030239)4.37916244
36establishment of integrated proviral latency (GO:0075713)4.35284647
37* regulation of sulfur metabolic process (GO:0042762)4.30565209
38tricarboxylic acid metabolic process (GO:0072350)4.28676354
39regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.28320831
40mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.28306697
41muscle filament sliding (GO:0030049)4.27659979
42actin-myosin filament sliding (GO:0033275)4.27659979
43oxidative phosphorylation (GO:0006119)4.19678156
44acetyl-CoA metabolic process (GO:0006084)4.14175273
45respiratory electron transport chain (GO:0022904)4.10707860
46regulation of translational fidelity (GO:0006450)4.07565192
47fatty acid catabolic process (GO:0009062)4.03259432
48oxaloacetate metabolic process (GO:0006107)4.01330284
49electron transport chain (GO:0022900)3.98921211
50fatty acid oxidation (GO:0019395)3.94761099
51ribosome assembly (GO:0042255)3.94602413
52biotin metabolic process (GO:0006768)3.93830096
53cell communication by electrical coupling (GO:0010644)3.88122118
54lipid oxidation (GO:0034440)3.87655617
55protein localization to chromosome, centromeric region (GO:0071459)3.86083038
56positive regulation of fatty acid oxidation (GO:0046321)3.84702848
57regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.84521523
58cell communication involved in cardiac conduction (GO:0086065)3.82853811
59IMP metabolic process (GO:0046040)3.82718323
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.81413505
61branched-chain amino acid catabolic process (GO:0009083)3.81059037
62sarcoplasmic reticulum calcium ion transport (GO:0070296)3.80462112
63regulation of skeletal muscle contraction (GO:0014819)3.79482268
64DNA strand elongation involved in DNA replication (GO:0006271)3.79012781
65pore complex assembly (GO:0046931)3.78343088
66ATP synthesis coupled proton transport (GO:0015986)3.77623893
67energy coupled proton transport, down electrochemical gradient (GO:0015985)3.77623893
68IMP biosynthetic process (GO:0006188)3.77586786
69regulation of cell communication by electrical coupling (GO:0010649)3.76746926
70quaternary ammonium group transport (GO:0015697)3.76631327
71cardiac muscle cell development (GO:0055013)3.76325458
72formation of translation preinitiation complex (GO:0001731)3.75194485
73regulation of actin filament-based movement (GO:1903115)3.74881768
74mitotic metaphase plate congression (GO:0007080)3.74484761
75regulation of relaxation of muscle (GO:1901077)3.72945007
76ventricular cardiac muscle cell action potential (GO:0086005)3.71681083
77mitotic sister chromatid segregation (GO:0000070)3.70508407
78protein localization to kinetochore (GO:0034501)3.68901275
79DNA strand elongation (GO:0022616)3.65717026
80regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.63731520
81short-chain fatty acid metabolic process (GO:0046459)3.62293232
82positive regulation of fatty acid beta-oxidation (GO:0032000)3.56373872
83sister chromatid segregation (GO:0000819)3.52963079
84striated muscle contraction (GO:0006941)3.52148087
85branched-chain amino acid metabolic process (GO:0009081)3.51177781
86valine metabolic process (GO:0006573)3.48911616
87cardiac cell development (GO:0055006)3.46953984
88carnitine metabolic process (GO:0009437)3.44691216
89actin-mediated cell contraction (GO:0070252)3.43709724
90regulation of membrane repolarization (GO:0060306)3.41457074
91mitotic sister chromatid cohesion (GO:0007064)3.40613134
92mitotic nuclear envelope disassembly (GO:0007077)3.36886353
93proline biosynthetic process (GO:0006561)3.36760004
94intracellular lipid transport (GO:0032365)3.36123955
95cardiac muscle hypertrophy (GO:0003300)3.36072996
96protein complex localization (GO:0031503)3.36039700
97cellular protein complex localization (GO:0034629)3.35753003
98monocarboxylic acid catabolic process (GO:0072329)3.35617622
99cellular ketone body metabolic process (GO:0046950)3.33309875
100actomyosin structure organization (GO:0031032)3.27910577
101heart trabecula formation (GO:0060347)3.26199372
102regulation of striated muscle contraction (GO:0006942)3.22968536
103acyl-CoA biosynthetic process (GO:0071616)3.22693034
104thioester biosynthetic process (GO:0035384)3.22693034
105telomere maintenance via semi-conservative replication (GO:0032201)3.21709998
106bundle of His cell to Purkinje myocyte communication (GO:0086069)3.21629679
107striated muscle hypertrophy (GO:0014897)3.20677610
108fatty acid homeostasis (GO:0055089)3.20370959
109tRNA aminoacylation for protein translation (GO:0006418)3.19329263
110regulation of fatty acid beta-oxidation (GO:0031998)3.17064223
111regulation of sarcomere organization (GO:0060297)3.15610022
112DNA replication initiation (GO:0006270)3.15436256
113metaphase plate congression (GO:0051310)3.14623662
114nuclear envelope disassembly (GO:0051081)3.14072953
115membrane disassembly (GO:0030397)3.14072953
116amino acid activation (GO:0043038)3.12900209
117tRNA aminoacylation (GO:0043039)3.12900209
118regulation of the force of heart contraction (GO:0002026)3.11950184
119purine nucleobase biosynthetic process (GO:0009113)3.11357753
120positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.10561772
121COPI coating of Golgi vesicle (GO:0048205)3.08874009
122Golgi transport vesicle coating (GO:0048200)3.08874009
123establishment of viral latency (GO:0019043)3.07700269
124cardiac muscle tissue morphogenesis (GO:0055008)3.05988531
125gluconeogenesis (GO:0006094)3.04635585
126lipid particle organization (GO:0034389)3.03976545
127nucleobase-containing small molecule interconversion (GO:0015949)3.00699711
128triglyceride catabolic process (GO:0019433)3.00099852
129DNA replication checkpoint (GO:0000076)2.95905518
130nucleobase biosynthetic process (GO:0046112)2.93598719
131adult heart development (GO:0007512)2.92952099
132chromosome condensation (GO:0030261)2.90969895
133negative regulation of cell size (GO:0045792)2.90505918
134ketone body metabolic process (GO:1902224)2.90289089
135regulation of calcium ion transmembrane transporter activity (GO:1901019)2.90152184
136regulation of calcium ion transmembrane transport (GO:1903169)2.90152184
137glycogen catabolic process (GO:0005980)2.90090344
138folic acid-containing compound biosynthetic process (GO:0009396)2.89227736
139regulation of mitotic spindle organization (GO:0060236)2.88446203
140neutral lipid catabolic process (GO:0046461)2.88299487
141acylglycerol catabolic process (GO:0046464)2.88299487
142relaxation of cardiac muscle (GO:0055119)2.88032104
143CENP-A containing nucleosome assembly (GO:0034080)2.86640746
144non-recombinational repair (GO:0000726)2.86479499
145double-strand break repair via nonhomologous end joining (GO:0006303)2.86479499
146regulation of sister chromatid cohesion (GO:0007063)2.85606431
147DNA ligation (GO:0006266)2.80222094
148ventricular cardiac muscle cell development (GO:0055015)2.77498329
149regulation of chromosome segregation (GO:0051983)2.77252091
150DNA topological change (GO:0006265)2.76510841
151peptidyl-arginine omega-N-methylation (GO:0035247)2.71874593
152telomere maintenance via recombination (GO:0000722)2.71567909
153mitotic recombination (GO:0006312)2.69458631
154regulation of mitochondrial translation (GO:0070129)2.69455493
155positive regulation of chromosome segregation (GO:0051984)2.68911016
156chromatin remodeling at centromere (GO:0031055)2.68800144
157L-serine metabolic process (GO:0006563)2.68569978
158regulation of translational termination (GO:0006449)2.65028582
159establishment of chromosome localization (GO:0051303)2.63594943
160negative regulation of chromosome segregation (GO:0051985)2.63441503
161regulation of translational elongation (GO:0006448)2.61146180
162mitotic spindle checkpoint (GO:0071174)2.57622574
163negative regulation of mitotic sister chromatid segregation (GO:0033048)2.57476865
164negative regulation of mitotic sister chromatid separation (GO:2000816)2.57476865
165negative regulation of sister chromatid segregation (GO:0033046)2.57476865
166negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.57476865
167negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.57476865
168regulation of spindle organization (GO:0090224)2.57061959
169spindle checkpoint (GO:0031577)2.56958307
170AMP metabolic process (GO:0046033)2.56651952
171regulation of centriole replication (GO:0046599)2.55906263
172ribosomal large subunit biogenesis (GO:0042273)2.54274867
173DNA duplex unwinding (GO:0032508)2.53915378
174nuclear envelope organization (GO:0006998)2.53588119
175DNA packaging (GO:0006323)2.52303659
176glutamine metabolic process (GO:0006541)2.52291474
177protein maturation by protein folding (GO:0022417)2.50056434
178hexose biosynthetic process (GO:0019319)2.48407384
179mitotic spindle assembly checkpoint (GO:0007094)2.48197548
180transcription from mitochondrial promoter (GO:0006390)2.47802238
181regulation of RNA export from nucleus (GO:0046831)2.47529182
182mitochondrial fusion (GO:0008053)2.47054358
183regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.45799111
184regulation of mitotic metaphase/anaphase transition (GO:0030071)2.45799111
185spindle assembly checkpoint (GO:0071173)2.45207396
186DNA geometric change (GO:0032392)2.43447500
187DNA replication-independent nucleosome organization (GO:0034724)2.41919833

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.35260695
2* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse5.43812568
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse5.20421126
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.71218755
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.37782315
6MYC_18555785_ChIP-Seq_MESCs_Mouse4.20147620
7ZNF263_19887448_ChIP-Seq_K562_Human3.74855020
8AR_21909140_ChIP-Seq_LNCAP_Human3.60626425
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.55654793
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26457517
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11690268
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.06897442
13CLOCK_20551151_ChIP-Seq_293T_Human2.97739384
14* RXR_22158963_ChIP-Seq_LIVER_Mouse2.96442937
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.87829217
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84007093
17* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.82048159
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81733453
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.68304232
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64419961
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.61516787
22TBX20_22080862_ChIP-Seq_HEART_Mouse2.54597266
23TBX20_22328084_ChIP-Seq_HEART_Mouse2.54597266
24* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.52137558
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.42619687
26* LXR_22158963_ChIP-Seq_LIVER_Mouse2.42205591
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39998184
28* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.30384778
29MYCN_18555785_ChIP-Seq_MESCs_Mouse2.24335295
30EZH2_22144423_ChIP-Seq_EOC_Human2.24048930
31* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.23373977
32* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.22631991
33THAP11_20581084_ChIP-Seq_MESCs_Mouse2.19841835
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.17611213
35E2F1_21310950_ChIP-Seq_MCF-7_Human2.16210562
36ESR1_20079471_ChIP-ChIP_T-47D_Human2.12647506
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11748202
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11602887
39XRN2_22483619_ChIP-Seq_HELA_Human2.10978543
40* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.05546756
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.04768191
42DCP1A_22483619_ChIP-Seq_HELA_Human2.04116749
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.01867517
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse10.0327119
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.97496161
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95595084
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.94002555
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91062835
49MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.86298782
50EST1_17652178_ChIP-ChIP_JURKAT_Human1.85054435
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.77754201
52PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.77496231
53TTF2_22483619_ChIP-Seq_HELA_Human1.68808969
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68718217
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63976719
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.60947152
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57902254
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56305551
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54906920
60ELK1_19687146_ChIP-ChIP_HELA_Human1.54207508
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.54123687
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.53203974
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52132150
64CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51869074
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51230619
66GABP_19822575_ChIP-Seq_HepG2_Human1.50496548
67DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.48379034
68ZNF274_21170338_ChIP-Seq_K562_Hela1.47506677
69* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.46863022
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41258032
71GATA4_21415370_ChIP-Seq_HL-1_Mouse1.39191474
72RARB_27405468_Chip-Seq_BRAIN_Mouse1.39147898
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33226305
74FOXP3_21729870_ChIP-Seq_TREG_Human1.32350454
75EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31409690
76TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.31327831
77E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29674949
78* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29216638
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28807885
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.28631725
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27843625
82SOX17_20123909_ChIP-Seq_XEN_Mouse1.26540869
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25870975
84EGR1_19374776_ChIP-ChIP_THP-1_Human1.25663209
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.24974558
86* ATF3_27146783_Chip-Seq_COLON_Human1.24111699
87SRF_21415370_ChIP-Seq_HL-1_Mouse1.19785968
88KDM5A_27292631_Chip-Seq_BREAST_Human1.18377253
89* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17532253
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16546529
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16420917
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16234647
93ESR2_21235772_ChIP-Seq_MCF-7_Human1.16196878
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14807087
95NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.14298749
96NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13665958
97TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.13611745
98CHD1_26751641_Chip-Seq_LNCaP_Human1.12613038
99EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11939095
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11013509
101BCAT_22108803_ChIP-Seq_LS180_Human1.10697630
102NANOG_21062744_ChIP-ChIP_HESCs_Human1.09879316
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09651107
104ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08873776
105* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07813089
106* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07751532
107POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06104863
108SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05832262
109HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05228382
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05164002
111VDR_23849224_ChIP-Seq_CD4+_Human1.04676697
112PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04130514
113TFEB_21752829_ChIP-Seq_HELA_Human1.03501495
114FOXA2_19822575_ChIP-Seq_HepG2_Human1.03032328
115SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02946647
116RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00868658
117GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.00743082
118MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00173734
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00154764
120* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99442315
121LXR_22292898_ChIP-Seq_THP-1_Human0.98273165
122* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97969890
123TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97672493
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96825434
125SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96219244
126NANOG_16153702_ChIP-ChIP_HESCs_Human0.95831400
127TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95314771
128NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95093812
129DROSHA_22980978_ChIP-Seq_HELA_Human0.95066534
130PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93921171
131YY1_21170310_ChIP-Seq_MESCs_Mouse0.93636210
132* RACK7_27058665_Chip-Seq_MCF-7_Human0.93445463
133SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93345406
134TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.91536620
135FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90730572
136KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90335282
137CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90213872
138* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90194887
139SOX2_21211035_ChIP-Seq_LN229_Gbm0.88298712
140P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88236157
141SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87093936
142ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85424564
143* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85247700
144ELF1_17652178_ChIP-ChIP_JURKAT_Human0.85055128
145* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84238803
146CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83619729
147EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83497098
148SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.83080303
149PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.82678962
150CREB1_26743006_Chip-Seq_LNCaP_Human0.82570601
151GATA1_22025678_ChIP-Seq_K562_Human0.82175408
152P68_20966046_ChIP-Seq_HELA_Human0.82163053
153TP63_22573176_ChIP-Seq_HFKS_Human0.81501355
154TRIM28_21343339_ChIP-Seq_HEK293_Human0.81417814
155POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.80602583
156KDM2B_26808549_Chip-Seq_DND41_Human0.80506261
157TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.79079883
158KLF4_19829295_ChIP-Seq_ESCs_Human0.78418864
159CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77718119
160MTF2_20144788_ChIP-Seq_MESCs_Mouse0.77705209
161REST_18959480_ChIP-ChIP_MESCs_Mouse0.77423506
162ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77258881
163* RUNX1_27514584_Chip-Seq_MCF-7_Human0.76931255
164DNAJC2_21179169_ChIP-ChIP_NT2_Human0.76436887
165* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.76067107
166AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75641429
167NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74749923
168NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74749923
169GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74634655
170* CTCF_27219007_Chip-Seq_Bcells_Human0.74028470
171TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.73162514
172EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.72787956
173FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.72443800
174DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.71819072
175FOXO3_23340844_ChIP-Seq_DLD1_Human0.70247754
176KDM2B_26808549_Chip-Seq_K562_Human0.69688445
177FOXH1_21741376_ChIP-Seq_ESCs_Human0.69237819
178SMC4_20622854_ChIP-Seq_HELA_Human0.68455173
179HNF4A_19822575_ChIP-Seq_HepG2_Human0.68192929
180EOMES_21245162_ChIP-Seq_HESCs_Human0.67765573
181BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.66131247
182CTCF_21964334_Chip-Seq_Bcells_Human0.65258817
183MITF_21258399_ChIP-Seq_MELANOMA_Human0.64780133

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.69511988
2MP0003646_muscle_fatigue5.27236662
3MP0000751_myopathy4.21901182
4MP0004084_abnormal_cardiac_muscle4.17364022
5MP0004215_abnormal_myocardial_fiber3.92767738
6MP0004130_abnormal_muscle_cell3.71560272
7MP0004957_abnormal_blastocyst_morpholog3.29676773
8MP0004036_abnormal_muscle_relaxation3.28784614
9MP0005330_cardiomyopathy3.25411752
10MP0010094_abnormal_chromosome_stability3.22387699
11MP0003693_abnormal_embryo_hatching3.15923767
12MP0000749_muscle_degeneration3.12783564
13MP0003111_abnormal_nucleus_morphology2.91965311
14MP0005670_abnormal_white_adipose2.76856174
15MP0004087_abnormal_muscle_fiber2.71407194
16MP0005666_abnormal_adipose_tissue2.70018942
17MP0008057_abnormal_DNA_replication2.60508777
18MP0003941_abnormal_skin_development2.53598477
19MP0008775_abnormal_heart_ventricle2.51828542
20MP0002972_abnormal_cardiac_muscle2.46090303
21MP0003077_abnormal_cell_cycle2.46079458
22MP0006036_abnormal_mitochondrial_physio2.40739353
23MP0005620_abnormal_muscle_contractility2.34680745
24MP0000750_abnormal_muscle_regeneration2.28161463
25MP0008932_abnormal_embryonic_tissue2.26112617
26MP0002269_muscular_atrophy2.22614679
27MP0001661_extended_life_span2.22462854
28MP0003137_abnormal_impulse_conducting2.19439473
29MP0004145_abnormal_muscle_electrophysio2.19105351
30MP0008058_abnormal_DNA_repair2.14554293
31MP0004185_abnormal_adipocyte_glucose2.13494020
32MP0005385_cardiovascular_system_phenoty2.13107960
33MP0001544_abnormal_cardiovascular_syste2.13107960
34MP0000747_muscle_weakness2.11663293
35MP0002106_abnormal_muscle_physiology2.08453345
36MP0004484_altered_response_of2.06716507
37MP0001730_embryonic_growth_arrest2.06257366
38MP0009697_abnormal_copulation2.02756299
39MP0004233_abnormal_muscle_weight2.01176365
40MP0010234_abnormal_vibrissa_follicle1.98974194
41MP0005451_abnormal_body_composition1.98123481
42MP0006138_congestive_heart_failure1.97439211
43MP0010630_abnormal_cardiac_muscle1.97029578
44MP0003221_abnormal_cardiomyocyte_apopto1.92084909
45MP0009672_abnormal_birth_weight1.91777178
46MP0000759_abnormal_skeletal_muscle1.87759071
47MP0005375_adipose_tissue_phenotype1.83419242
48MP0010352_gastrointestinal_tract_polyps1.80976435
49MP0002971_abnormal_brown_adipose1.74373437
50MP0008007_abnormal_cellular_replicative1.70859590
51MP0005380_embryogenesis_phenotype1.70823875
52MP0001672_abnormal_embryogenesis/_devel1.70823875
53MP0005369_muscle_phenotype1.66343471
54MP0000013_abnormal_adipose_tissue1.65228741
55MP0003984_embryonic_growth_retardation1.63233476
56MP0004085_abnormal_heartbeat1.61815144
57MP0002088_abnormal_embryonic_growth/wei1.57593085
58MP0001697_abnormal_embryo_size1.56992025
59MP0002332_abnormal_exercise_endurance1.54315373
60MP0000350_abnormal_cell_proliferation1.51774640
61MP0006035_abnormal_mitochondrial_morpho1.47156066
62MP0002139_abnormal_hepatobiliary_system1.44754391
63MP0002080_prenatal_lethality1.44460236
64MP0004043_abnormal_pH_regulation1.41292241
65MP0003890_abnormal_embryonic-extraembry1.37664878
66MP0004272_abnormal_basement_membrane1.33287132
67MP0005332_abnormal_amino_acid1.32926227
68MP0005360_urolithiasis1.32817439
69MP0003705_abnormal_hypodermis_morpholog1.32499904
70MP0002084_abnormal_developmental_patter1.31236101
71MP0003806_abnormal_nucleotide_metabolis1.30878171
72MP0003828_pulmonary_edema1.28345444
73MP0005085_abnormal_gallbladder_physiolo1.26404074
74MP0005535_abnormal_body_temperature1.25292885
75MP0000003_abnormal_adipose_tissue1.23478036
76MP0003718_maternal_effect1.23226798
77MP0004197_abnormal_fetal_growth/weight/1.22035953
78MP0002086_abnormal_extraembryonic_tissu1.21049803
79MP0002909_abnormal_adrenal_gland1.19763946
80MP0002085_abnormal_embryonic_tissue1.19503769
81MP0010329_abnormal_lipoprotein_level1.14823171
82MP0000537_abnormal_urethra_morphology1.11507469
83MP0002118_abnormal_lipid_homeostasis1.10039201
84MP0004859_abnormal_synaptic_plasticity1.09354037
85MP0005266_abnormal_metabolism1.08810136
86MP0009703_decreased_birth_body1.06794219
87MP0002697_abnormal_eye_size1.04285317
88MP0002078_abnormal_glucose_homeostasis1.04140771
89MP0005584_abnormal_enzyme/coenzyme_acti1.03407186
90MP0003385_abnormal_body_wall0.99963187
91MP0003315_abnormal_perineum_morphology0.99939829
92MP0005365_abnormal_bile_salt0.99131020
93MP0002009_preneoplasia0.98394465
94MP0003937_abnormal_limbs/digits/tail_de0.97953068
95MP0002796_impaired_skin_barrier0.97556561
96MP0005319_abnormal_enzyme/_coenzyme0.95593760
97MP0000313_abnormal_cell_death0.93408052
98MP0005501_abnormal_skin_physiology0.93226241
99MP0002127_abnormal_cardiovascular_syste0.92559111
100MP0003329_amyloid_beta_deposits0.89486042
101MP0008961_abnormal_basal_metabolism0.89449020
102MP0000733_abnormal_muscle_development0.86608943
103MP0003786_premature_aging0.85817893
104MP0000266_abnormal_heart_morphology0.84915214
105MP0000230_abnormal_systemic_arterial0.84539401
106MP0001727_abnormal_embryo_implantation0.84345158
107MP0003195_calcinosis0.82748668
108MP0005334_abnormal_fat_pad0.82705385
109MP0002970_abnormal_white_adipose0.82363446
110MP0004510_myositis0.82184549
111MP0009780_abnormal_chondrocyte_physiolo0.81945646
112MP0004147_increased_porphyrin_level0.81526683
113MP0005165_increased_susceptibility_to0.81128430
114MP0000343_altered_response_to0.80596694
115MP0010030_abnormal_orbit_morphology0.77907838
116MP0000762_abnormal_tongue_morphology0.77831850
117MP0009115_abnormal_fat_cell0.75942394
118MP0003186_abnormal_redox_activity0.75120930
119MP0004924_abnormal_behavior0.74899820
120MP0005386_behavior/neurological_phenoty0.74899820
121MP0003567_abnormal_fetal_cardiomyocyte0.74675615
122MP0001915_intracranial_hemorrhage0.74283781
123MP0010307_abnormal_tumor_latency0.73562962
124MP0004264_abnormal_extraembryonic_tissu0.73488382
125MP0002108_abnormal_muscle_morphology0.71020904
126MP0005076_abnormal_cell_differentiation0.69054986
127MP0003950_abnormal_plasma_membrane0.68339462
128MP0001299_abnormal_eye_distance/0.68130440
129MP0002111_abnormal_tail_morphology0.67670677
130MP0005452_abnormal_adipose_tissue0.64329876
131MP0002822_catalepsy0.63820127
132MP0000609_abnormal_liver_physiology0.63419002
133MP0002234_abnormal_pharynx_morphology0.61642917
134MP0005623_abnormal_meninges_morphology0.60538756
135MP0005187_abnormal_penis_morphology0.60219377
136MP0008438_abnormal_cutaneous_collagen0.59858126
137MP0008875_abnormal_xenobiotic_pharmacok0.59307900
138MP0005448_abnormal_energy_balance0.57700194
139MP0003566_abnormal_cell_adhesion0.56142266
140MP0009643_abnormal_urine_homeostasis0.54565322
141MP0010368_abnormal_lymphatic_system0.53420741
142MP0003279_aneurysm0.53199050
143MP0003635_abnormal_synaptic_transmissio0.52656999
144MP0003959_abnormal_lean_body0.52652177
145MP0009046_muscle_twitch0.52583616
146MP0002128_abnormal_blood_circulation0.49076529
147MP0009840_abnormal_foam_cell0.48302786
148MP0005083_abnormal_biliary_tract0.47804086
149MP0004270_analgesia0.47380140
150MP0005275_abnormal_skin_tensile0.46631301
151MP0003252_abnormal_bile_duct0.45869924
152MP0002877_abnormal_melanocyte_morpholog0.45300029
153MP0000358_abnormal_cell_content/0.44835154

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.70248114
2Myoglobinuria (HP:0002913)5.63272363
3Exercise-induced myalgia (HP:0003738)5.17569328
4Exercise-induced muscle cramps (HP:0003710)4.81518998
5Nemaline bodies (HP:0003798)4.57725274
6Rhabdomyolysis (HP:0003201)4.46674239
7Calf muscle hypertrophy (HP:0008981)4.30883371
8Ventricular tachycardia (HP:0004756)4.19964513
9Muscle hypertrophy of the lower extremities (HP:0008968)4.05998782
10Muscle fiber splitting (HP:0003555)3.95551113
11Hyporeflexia of lower limbs (HP:0002600)3.86426199
12Atrial fibrillation (HP:0005110)3.79089087
13Ketoacidosis (HP:0001993)3.76894993
14Hypoglycemic coma (HP:0001325)3.71352601
15Abnormality of the calf musculature (HP:0001430)3.67878688
16Palpitations (HP:0001962)3.66652030
17Lipoatrophy (HP:0100578)3.62985656
18Primary atrial arrhythmia (HP:0001692)3.56529575
19Abnormality of fatty-acid metabolism (HP:0004359)3.45361868
20Supraventricular tachycardia (HP:0004755)3.43261190
21Difficulty running (HP:0009046)3.42236927
22Hepatic necrosis (HP:0002605)3.42079643
23Bundle branch block (HP:0011710)3.41228609
24Supraventricular arrhythmia (HP:0005115)3.37671075
25Hyperglycinuria (HP:0003108)3.36802167
26Increased connective tissue (HP:0009025)3.33174513
27Right ventricular cardiomyopathy (HP:0011663)3.32907290
28Dicarboxylic aciduria (HP:0003215)3.26974081
29Abnormality of dicarboxylic acid metabolism (HP:0010995)3.26974081
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.26308794
31Abnormality of alanine metabolism (HP:0010916)3.26308794
32Hyperalaninemia (HP:0003348)3.26308794
33Syncope (HP:0001279)3.26142835
34Progressive muscle weakness (HP:0003323)3.24524087
35Ketosis (HP:0001946)3.19800597
36Abnormal mitochondria in muscle tissue (HP:0008316)3.18905270
37Increased muscle lipid content (HP:0009058)3.17835417
38Subaortic stenosis (HP:0001682)3.15510396
39Abnormality of the left ventricular outflow tract (HP:0011103)3.15510396
40Dilated cardiomyopathy (HP:0001644)3.05826383
41Progressive external ophthalmoplegia (HP:0000590)3.03787303
42Acute encephalopathy (HP:0006846)3.03496125
43Centrally nucleated skeletal muscle fibers (HP:0003687)3.02413950
44EMG: myopathic abnormalities (HP:0003458)3.02243928
45Asymmetric septal hypertrophy (HP:0001670)2.97921205
46Acute necrotizing encephalopathy (HP:0006965)2.96911253
47Hyperammonemia (HP:0001987)2.95278338
48Ventricular arrhythmia (HP:0004308)2.94072508
49Myotonia (HP:0002486)2.93916220
50Increased serum pyruvate (HP:0003542)2.92883045
51Abnormality of glycolysis (HP:0004366)2.92883045
52Cerebral edema (HP:0002181)2.90657800
53Muscle stiffness (HP:0003552)2.88821405
54Rimmed vacuoles (HP:0003805)2.86072511
55Abnormality of serine family amino acid metabolism (HP:0010894)2.85212064
56Abnormality of glycine metabolism (HP:0010895)2.85212064
57Conjunctival hamartoma (HP:0100780)2.81412823
58Atrioventricular block (HP:0001678)2.81174270
59Hepatocellular necrosis (HP:0001404)2.80340665
60Prolonged QT interval (HP:0001657)2.78813091
61Pheochromocytoma (HP:0002666)2.76050356
62Heart block (HP:0012722)2.74849646
63Ventricular fibrillation (HP:0001663)2.73584542
64Multiple enchondromatosis (HP:0005701)2.72363703
65Myopathic facies (HP:0002058)2.68309644
66Difficulty climbing stairs (HP:0003551)2.66434366
67Abnormal atrioventricular conduction (HP:0005150)2.63420436
68Progressive macrocephaly (HP:0004481)2.58805427
69Cortical dysplasia (HP:0002539)2.53758803
70Neck muscle weakness (HP:0000467)2.53358523
71Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.51428377
72Microvesicular hepatic steatosis (HP:0001414)2.51085292
73Ragged-red muscle fibers (HP:0003200)2.50372123
74Chromosomal breakage induced by crosslinking agents (HP:0003221)2.49723169
75* Lactic acidosis (HP:0003128)2.49460443
76Increased CSF lactate (HP:0002490)2.48976867
77Increased intramyocellular lipid droplets (HP:0012240)2.48975375
78Chromsome breakage (HP:0040012)2.46776123
79Neuroendocrine neoplasm (HP:0100634)2.45864655
80Dysmetric saccades (HP:0000641)2.44890679
81Generalized aminoaciduria (HP:0002909)2.39750807
82Mitochondrial inheritance (HP:0001427)2.38248225
83Athetosis (HP:0002305)2.38110057
84Type 1 muscle fiber predominance (HP:0003803)2.37673162
85Increased variability in muscle fiber diameter (HP:0003557)2.36256895
86Hamartoma of the eye (HP:0010568)2.35479783
87Muscle fiber inclusion bodies (HP:0100299)2.27395750
88Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.20743014
89Shoulder girdle muscle weakness (HP:0003547)2.20595724
90Respiratory failure (HP:0002878)2.18583865
91Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.18171485
92Termporal pattern (HP:0011008)2.16266076
93Insidious onset (HP:0003587)2.16266076
94Lethargy (HP:0001254)2.14787853
95Increased nuchal translucency (HP:0010880)2.12194464
96Exercise intolerance (HP:0003546)2.11850238
97Abnormality of skeletal muscle fiber size (HP:0012084)2.11104826
98Hyperglycinemia (HP:0002154)2.10577188
99Neoplasm of the adrenal gland (HP:0100631)2.08610135
100Hypoalphalipoproteinemia (HP:0003233)2.07666002
101Abnormal EKG (HP:0003115)2.06947837
102Calcaneovalgus deformity (HP:0001848)2.06751806
103Abnormal gallbladder physiology (HP:0012438)2.06194696
104Cholecystitis (HP:0001082)2.06194696
105Metabolic acidosis (HP:0001942)1.99897185
106Nausea (HP:0002018)1.99240159
107Limb-girdle muscle atrophy (HP:0003797)1.99139219
108Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.97862775
109Decreased activity of mitochondrial respiratory chain (HP:0008972)1.97862775
110Nephroblastoma (Wilms tumor) (HP:0002667)1.97220032
111Esophageal neoplasm (HP:0100751)1.96196609
112Neoplasm of head and neck (HP:0012288)1.96196609
113Distal lower limb muscle weakness (HP:0009053)1.96131246
114Left ventricular hypertrophy (HP:0001712)1.95919107
115Embryonal renal neoplasm (HP:0011794)1.95723453
116Gout (HP:0001997)1.93588279
117Oligomenorrhea (HP:0000876)1.92917630
118Proximal tubulopathy (HP:0000114)1.92433991
119Areflexia of lower limbs (HP:0002522)1.91211723
120Hyperinsulinemic hypoglycemia (HP:0000825)1.89671140
121Abnormality of the umbilical cord (HP:0010881)1.89223074
122Abnormality of methionine metabolism (HP:0010901)1.87779082
123Proximal placement of thumb (HP:0009623)1.87138475
124Lipid accumulation in hepatocytes (HP:0006561)1.86375805
125Deviation of the thumb (HP:0009603)1.86069289
126Methylmalonic aciduria (HP:0012120)1.84498963
127Central scotoma (HP:0000603)1.83860237
128Reduced antithrombin III activity (HP:0001976)1.80119767
129Microglossia (HP:0000171)1.79950331
130Distal arthrogryposis (HP:0005684)1.77871068
131Abnormal lung lobation (HP:0002101)1.77473024
132Abnormalities of placenta or umbilical cord (HP:0001194)1.77039780
133Birth length less than 3rd percentile (HP:0003561)1.76343408
134Pelvic girdle muscle weakness (HP:0003749)1.76085887
135Abnormality of the calcaneus (HP:0008364)1.75059172
136Impaired pain sensation (HP:0007328)1.74443755
137Abnormality of pain sensation (HP:0010832)1.74443755
138Deformed tarsal bones (HP:0008119)1.73453763
139Hypoplastic left heart (HP:0004383)1.70520628
140Ankyloglossia (HP:0010296)1.68233142
141Abnormal umbilical cord blood vessels (HP:0011403)1.67726553
142Single umbilical artery (HP:0001195)1.67726553
143Abnormality of the fetal cardiovascular system (HP:0010948)1.67726553
144Abnormality of the hip-girdle musculature (HP:0001445)1.62030700
145Abnormality of the musculature of the pelvis (HP:0001469)1.62030700
146Overlapping toe (HP:0001845)1.61929875
147Abnormality of the tricuspid valve (HP:0001702)1.61275508
148Breech presentation (HP:0001623)1.59502492
149Round ear (HP:0100830)1.57367454
150Distal lower limb amyotrophy (HP:0008944)1.54154041
151Missing ribs (HP:0000921)1.52720862
152Abnormal cartilage morphology (HP:0002763)1.52366819
153Spastic diplegia (HP:0001264)1.51732981
154Mildly elevated creatine phosphokinase (HP:0008180)1.50500975
155Selective tooth agenesis (HP:0001592)1.49089112
156Abnormality of the intrinsic pathway (HP:0010989)1.48486623

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.85584262
2PDK44.85584262
3TTN3.99847868
4BCKDK3.79000857
5TRIB33.63854618
6NEK13.33271099
7LMTK23.28455955
8PKN23.27149563
9TTK3.26211898
10PBK3.25958617
11TSSK63.21777570
12PHKG13.16464947
13PHKG23.16464947
14BUB13.11974123
15CDC72.94012659
16OBSCN2.93794991
17SRPK12.93600036
18PDK22.74148956
19EIF2AK12.57399462
20EIF2AK32.18038785
21DMPK1.94793916
22WEE11.88090496
23PINK11.86480852
24PLK41.86108750
25BRSK21.77384368
26MYLK1.76954651
27MAP3K101.72988200
28CDK121.68940263
29SMG11.53289608
30ICK1.50634016
31PLK31.42073743
32RIPK11.38251696
33MKNK11.37299600
34KSR21.31604476
35PAK31.30261701
36MAP2K41.29910413
37MAP3K41.26411847
38CAMK1D1.26269705
39PIK3CA1.25404440
40LATS21.24402172
41WNK41.23890983
42PLK11.20722421
43VRK21.19254571
44MST41.18866001
45MAP3K71.16055482
46BRSK11.13476198
47NEK21.11335317
48RPS6KB21.10073017
49CHEK21.09912258
50NME21.08545076
51STK381.07882703
52AURKB1.03976086
53CCNB11.02065619
54STK241.01942179
55CDK71.00993288
56SIK10.99624839
57PAK40.99189014
58ERBB40.99105622
59CHEK10.98754423
60CAMK1G0.96904514
61ILK0.96754655
62FLT30.96004537
63MKNK20.94984454
64MINK10.94630550
65MAP3K90.92942805
66PRKAA20.91981978
67MAP3K80.91293619
68CDK60.90756498
69PAK60.90435343
70PRKAA10.90405709
71BRAF0.87165939
72MAPKAPK30.86337705
73NTRK30.85979132
74SCYL20.85827258
75PNCK0.84838106
76PRKD30.84676467
77CAMK2D0.82829952
78STK160.82153590
79ATR0.81217944
80MAP3K50.79381077
81TIE10.78879089
82PDGFRA0.78278336
83TAOK10.78180653
84PDPK10.77155143
85STK40.76720330
86EIF2AK20.75759412
87PDK10.74385030
88PRKD10.74184169
89MET0.72671215
90GRK70.72611375
91RET0.72170345
92MUSK0.71619928
93CAMK10.70568723
94ALK0.70120166
95CDK40.70048781
96STK30.70021762
97TAF10.68508826
98CDK80.67882740
99RPS6KA40.67288206
100ZAK0.66308131
101MAPK120.65622196
102EPHA20.64595028
103PTK2B0.62388507
104FER0.62163400
105ERBB30.61736223
106ATM0.61492856
107CDK10.60538220
108MAP2K10.59097744
109CAMKK10.55991437
110AURKA0.55628783
111STK38L0.54709804
112MAP3K110.54274626
113ROCK10.53270161
114CAMK40.52792433
115CLK10.51678084
116CDK20.51609576
117CAMK2A0.51352974
118MAP3K20.50341532
119DAPK30.50317665
120BRD40.50262691
121CSNK1E0.50168239
122PRKACG0.49948694
123VRK10.49803789
124DAPK20.49237709
125MAPKAPK50.48717196
126KSR10.48020648
127CSNK2A20.46757767
128EPHA40.45805155
129LIMK10.45560717
130WNK10.44252401
131LRRK20.43415829
132ARAF0.42440135
133NME10.42218607
134KDR0.41661246
135PAK20.40967928
136INSRR0.40739418
137NEK90.39949630
138MAP2K30.39928958
139AKT20.39542332
140CAMK2G0.38601345
141CDK90.37920672
142PRKDC0.37187029
143STK110.36614323
144CDC42BPA0.35986818
145CSNK2A10.35789706
146CAMKK20.35441671
147TESK10.35104572
148TRPM70.33981965
149CDK180.32996994
150MAP3K10.32836951
151CDK140.32256183
152EEF2K0.32088212
153STK100.32070331
154PTK60.32044084
155MTOR0.30841373
156PRKACA0.30471438
157NTRK10.30167276
158STK390.29829725
159RPS6KA30.29672458
160PRKACB0.28318557
161LATS10.27927089
162ABL20.27744896
163MAPK110.26287849
164MARK10.25523949
165CDK50.24208378
166SGK30.24194830
167RAF10.22620018
168FGFR10.22107934
169MST1R0.21962200
170ROCK20.21494830
171WNK30.21416770

Predicted pathways (KEGG)

RankGene SetZ-score
1* Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.79072952
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.25212462
3Propanoate metabolism_Homo sapiens_hsa006404.06951290
4Fatty acid degradation_Homo sapiens_hsa000713.33181787
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.04544989
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.97105573
7DNA replication_Homo sapiens_hsa030302.93471820
8Fatty acid metabolism_Homo sapiens_hsa012122.87880946
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.77062205
10* Carbon metabolism_Homo sapiens_hsa012002.72077225
11Cardiac muscle contraction_Homo sapiens_hsa042602.55355830
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.53297182
13Mismatch repair_Homo sapiens_hsa034302.45369103
14* Pyruvate metabolism_Homo sapiens_hsa006202.37910278
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18556230
16Parkinsons disease_Homo sapiens_hsa050122.16203867
17Oxidative phosphorylation_Homo sapiens_hsa001902.11061635
18Butanoate metabolism_Homo sapiens_hsa006502.08541421
19Non-homologous end-joining_Homo sapiens_hsa034502.06598612
20PPAR signaling pathway_Homo sapiens_hsa033201.90219603
21RNA transport_Homo sapiens_hsa030131.88873416
22One carbon pool by folate_Homo sapiens_hsa006701.87993255
23Cell cycle_Homo sapiens_hsa041101.86453484
24Fatty acid biosynthesis_Homo sapiens_hsa000611.83897369
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.79892588
26Dilated cardiomyopathy_Homo sapiens_hsa054141.76280465
27Nitrogen metabolism_Homo sapiens_hsa009101.72574581
28Spliceosome_Homo sapiens_hsa030401.68376114
29Proteasome_Homo sapiens_hsa030501.65636282
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.61285332
31Alzheimers disease_Homo sapiens_hsa050101.60733161
32Nucleotide excision repair_Homo sapiens_hsa034201.58924687
33Biosynthesis of amino acids_Homo sapiens_hsa012301.55923126
34Base excision repair_Homo sapiens_hsa034101.50934157
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.50017845
36* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.44388201
37Steroid biosynthesis_Homo sapiens_hsa001001.41637863
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38656762
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38139477
40Arginine biosynthesis_Homo sapiens_hsa002201.35440253
41Huntingtons disease_Homo sapiens_hsa050161.33450014
42Fatty acid elongation_Homo sapiens_hsa000621.26958129
43mRNA surveillance pathway_Homo sapiens_hsa030151.24486782
44Glucagon signaling pathway_Homo sapiens_hsa049221.20656498
45Tryptophan metabolism_Homo sapiens_hsa003801.19675518
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15647006
47beta-Alanine metabolism_Homo sapiens_hsa004101.13441857
48Vitamin B6 metabolism_Homo sapiens_hsa007501.12332539
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11632299
50Adipocytokine signaling pathway_Homo sapiens_hsa049201.07224152
51Homologous recombination_Homo sapiens_hsa034401.06758229
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06245114
53Peroxisome_Homo sapiens_hsa041461.04761703
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04348521
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99779372
56Insulin signaling pathway_Homo sapiens_hsa049100.96951764
57AMPK signaling pathway_Homo sapiens_hsa041520.95131391
58Oocyte meiosis_Homo sapiens_hsa041140.94695488
59RNA degradation_Homo sapiens_hsa030180.94543363
60Thyroid cancer_Homo sapiens_hsa052160.94510960
61Insulin resistance_Homo sapiens_hsa049310.91570184
62Starch and sucrose metabolism_Homo sapiens_hsa005000.91464659
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88553597
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88095357
65Pyrimidine metabolism_Homo sapiens_hsa002400.87144458
66RNA polymerase_Homo sapiens_hsa030200.86833983
67Fanconi anemia pathway_Homo sapiens_hsa034600.86518531
68Glycerolipid metabolism_Homo sapiens_hsa005610.84838082
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83028537
70Sulfur relay system_Homo sapiens_hsa041220.79162780
71Basal transcription factors_Homo sapiens_hsa030220.79068890
72Purine metabolism_Homo sapiens_hsa002300.78433762
73Ribosome_Homo sapiens_hsa030100.77329053
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.73469342
75Folate biosynthesis_Homo sapiens_hsa007900.73243208
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.72457095
77Protein export_Homo sapiens_hsa030600.69163460
78Adherens junction_Homo sapiens_hsa045200.67832923
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67224638
80Bile secretion_Homo sapiens_hsa049760.64693792
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62117248
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60377102
83Glutathione metabolism_Homo sapiens_hsa004800.59799701
84Pentose phosphate pathway_Homo sapiens_hsa000300.57749866
85Gastric acid secretion_Homo sapiens_hsa049710.56972422
86Lysine degradation_Homo sapiens_hsa003100.56732339
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56067190
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55292178
89Galactose metabolism_Homo sapiens_hsa000520.54898793
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54408513
91Fat digestion and absorption_Homo sapiens_hsa049750.54174614
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53967670
93Phenylalanine metabolism_Homo sapiens_hsa003600.53945347
94N-Glycan biosynthesis_Homo sapiens_hsa005100.53879161
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.53856739
96Renin secretion_Homo sapiens_hsa049240.52339863
97Oxytocin signaling pathway_Homo sapiens_hsa049210.52122910
98Fructose and mannose metabolism_Homo sapiens_hsa000510.51974329
99Calcium signaling pathway_Homo sapiens_hsa040200.50238102
100Viral myocarditis_Homo sapiens_hsa054160.49885563
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49237365
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48456937
103Type II diabetes mellitus_Homo sapiens_hsa049300.47822040
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46313778
105HIF-1 signaling pathway_Homo sapiens_hsa040660.43808964
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42967633
107Long-term potentiation_Homo sapiens_hsa047200.42344038
108Caffeine metabolism_Homo sapiens_hsa002320.42329516
109Arginine and proline metabolism_Homo sapiens_hsa003300.41994937
110p53 signaling pathway_Homo sapiens_hsa041150.39381471
111Insulin secretion_Homo sapiens_hsa049110.38601922
112Circadian entrainment_Homo sapiens_hsa047130.36878340
113mTOR signaling pathway_Homo sapiens_hsa041500.35927639
114Sulfur metabolism_Homo sapiens_hsa009200.35589659
115Hippo signaling pathway_Homo sapiens_hsa043900.34980091
116Salivary secretion_Homo sapiens_hsa049700.32394512
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31720654
118* Metabolic pathways_Homo sapiens_hsa011000.30398790
119Tyrosine metabolism_Homo sapiens_hsa003500.30374318
120cAMP signaling pathway_Homo sapiens_hsa040240.30177567
121Small cell lung cancer_Homo sapiens_hsa052220.29085456
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.28178404
123Viral carcinogenesis_Homo sapiens_hsa052030.28026400
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27641812
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.27365334
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26717473
127Alcoholism_Homo sapiens_hsa050340.26399787
128Chronic myeloid leukemia_Homo sapiens_hsa052200.25667293
129TGF-beta signaling pathway_Homo sapiens_hsa043500.23944243
130Dopaminergic synapse_Homo sapiens_hsa047280.23779894
131Synaptic vesicle cycle_Homo sapiens_hsa047210.23328337
132GABAergic synapse_Homo sapiens_hsa047270.21646272
133GnRH signaling pathway_Homo sapiens_hsa049120.21493275
134Selenocompound metabolism_Homo sapiens_hsa004500.21414771
135Olfactory transduction_Homo sapiens_hsa047400.21107027
136Focal adhesion_Homo sapiens_hsa045100.20792665
137Gap junction_Homo sapiens_hsa045400.20110189
138Amphetamine addiction_Homo sapiens_hsa050310.19013157
139Cholinergic synapse_Homo sapiens_hsa047250.19004769
140Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.17174944
141Estrogen signaling pathway_Homo sapiens_hsa049150.17024992
142Circadian rhythm_Homo sapiens_hsa047100.16983601
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16912709
144Tight junction_Homo sapiens_hsa045300.16203015
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.14836309
146Dorso-ventral axis formation_Homo sapiens_hsa043200.12626517

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