DLEC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)9.88707486
2regulation of cilium movement (GO:0003352)9.53358124
3left/right pattern formation (GO:0060972)8.36675183
4left/right axis specification (GO:0070986)7.08701852
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.38883075
6L-phenylalanine catabolic process (GO:0006559)6.38883075
7ventricular system development (GO:0021591)6.34843022
8aromatic amino acid family catabolic process (GO:0009074)6.33170780
9indole-containing compound catabolic process (GO:0042436)6.26581153
10indolalkylamine catabolic process (GO:0046218)6.26581153
11tryptophan catabolic process (GO:0006569)6.26581153
12L-phenylalanine metabolic process (GO:0006558)6.13859796
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.13859796
14primary alcohol catabolic process (GO:0034310)6.06069557
15tryptophan metabolic process (GO:0006568)5.96691979
16intraciliary transport (GO:0042073)5.90873424
17microtubule bundle formation (GO:0001578)5.82700287
18cilium organization (GO:0044782)5.72158572
19vitamin transmembrane transport (GO:0035461)5.68816129
20kynurenine metabolic process (GO:0070189)5.59107446
21regulation of microtubule-based movement (GO:0060632)5.56561241
22cilium assembly (GO:0042384)5.51331741
23tolerance induction (GO:0002507)5.39339192
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.28839779
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.20784518
26ethanol metabolic process (GO:0006067)5.17175729
27glyoxylate metabolic process (GO:0046487)5.14366316
28diterpenoid biosynthetic process (GO:0016102)5.07594194
29drug catabolic process (GO:0042737)5.07224186
30cellular response to exogenous dsRNA (GO:0071360)4.89755452
31aminoglycoside antibiotic metabolic process (GO:0030647)4.88276900
32alpha-linolenic acid metabolic process (GO:0036109)4.83646931
33amino-acid betaine metabolic process (GO:0006577)4.83120385
34coenzyme catabolic process (GO:0009109)4.81369020
35response to xenobiotic stimulus (GO:0009410)4.79224089
36organic cation transport (GO:0015695)4.78406653
37urea cycle (GO:0000050)4.74125094
38urea metabolic process (GO:0019627)4.74125094
39bile acid biosynthetic process (GO:0006699)4.73155170
40drug transmembrane transport (GO:0006855)4.70541683
41protein localization to cilium (GO:0061512)4.63279642
42aromatic amino acid family metabolic process (GO:0009072)4.62932220
43high-density lipoprotein particle remodeling (GO:0034375)4.62176578
44serine family amino acid catabolic process (GO:0009071)4.61154075
45indolalkylamine metabolic process (GO:0006586)4.58515911
46lysine catabolic process (GO:0006554)4.57310644
47lysine metabolic process (GO:0006553)4.57310644
48sulfur amino acid catabolic process (GO:0000098)4.56109777
49polyketide metabolic process (GO:0030638)4.52787416
50doxorubicin metabolic process (GO:0044598)4.52787416
51daunorubicin metabolic process (GO:0044597)4.52787416
52exogenous drug catabolic process (GO:0042738)4.51790847
53pyrimidine-containing compound transmembrane transport (GO:0072531)4.50240613
54amine catabolic process (GO:0009310)4.46895184
55cellular biogenic amine catabolic process (GO:0042402)4.46895184
56cysteine metabolic process (GO:0006534)4.46797730
57centriole assembly (GO:0098534)4.45457361
58homocysteine metabolic process (GO:0050667)4.41829909
59positive regulation of smoothened signaling pathway (GO:0045880)4.41695220
60nitrogen cycle metabolic process (GO:0071941)4.35494183
61cellular component assembly involved in morphogenesis (GO:0010927)4.34384044
62microtubule-based movement (GO:0007018)4.32812568
63regulation of triglyceride catabolic process (GO:0010896)4.31322907
64phospholipid efflux (GO:0033700)4.29747494
65lateral ventricle development (GO:0021670)4.29469548
66regulation of interleukin-5 production (GO:0032674)4.26378945
67alpha-amino acid catabolic process (GO:1901606)4.25536049
68cilium or flagellum-dependent cell motility (GO:0001539)4.24953758
69bile acid metabolic process (GO:0008206)4.21823995
70cilium morphogenesis (GO:0060271)4.20327370
71cellular ketone body metabolic process (GO:0046950)4.12217006
72urate metabolic process (GO:0046415)4.10365528
73negative regulation of T cell differentiation in thymus (GO:0033085)4.08568402
74NAD biosynthetic process (GO:0009435)4.06879643
75regulation of cholesterol esterification (GO:0010872)4.06494119
76reverse cholesterol transport (GO:0043691)4.06485033
77lung epithelium development (GO:0060428)4.06266807
78one-carbon compound transport (GO:0019755)4.01966188
79cellular modified amino acid catabolic process (GO:0042219)4.01211250
80cell projection assembly (GO:0030031)4.00125162
81tyrosine metabolic process (GO:0006570)3.98879061
82negative regulation of B cell mediated immunity (GO:0002713)3.98778915
83negative regulation of immunoglobulin mediated immune response (GO:0002890)3.98778915
84negative regulation of cholesterol transport (GO:0032375)3.98277245
85negative regulation of sterol transport (GO:0032372)3.98277245
86carnitine metabolic process (GO:0009437)3.96460281
87protein carboxylation (GO:0018214)3.95487825
88peptidyl-glutamic acid carboxylation (GO:0017187)3.95487825
89cellular amino acid catabolic process (GO:0009063)3.93959921
90negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.92512441
91acylglycerol homeostasis (GO:0055090)3.90858829
92triglyceride homeostasis (GO:0070328)3.90858829
93drug transport (GO:0015893)3.89049657
94CDP-diacylglycerol biosynthetic process (GO:0016024)3.87672698
95protein-lipid complex remodeling (GO:0034368)3.86133751
96macromolecular complex remodeling (GO:0034367)3.86133751
97plasma lipoprotein particle remodeling (GO:0034369)3.86133751
98regulation of germinal center formation (GO:0002634)3.83585538
99pyridine nucleotide biosynthetic process (GO:0019363)3.79336283
100nicotinamide nucleotide biosynthetic process (GO:0019359)3.79336283
101benzene-containing compound metabolic process (GO:0042537)3.76354374
102short-chain fatty acid metabolic process (GO:0046459)3.74665184
103ethanol oxidation (GO:0006069)3.72879331
104cofactor catabolic process (GO:0051187)3.71595061
105retina layer formation (GO:0010842)3.71341164
106negative regulation of humoral immune response (GO:0002921)3.70692479
107retinoic acid metabolic process (GO:0042573)3.68786196
108positive regulation of tolerance induction (GO:0002645)3.68380129
109negative regulation of fibrinolysis (GO:0051918)3.66457369
110regulation of fibrinolysis (GO:0051917)3.64475943
111sperm capacitation (GO:0048240)3.63293649
112regulation of interleukin-13 production (GO:0032656)3.62641443
113bile acid and bile salt transport (GO:0015721)3.62314283
114regulation of apoptotic cell clearance (GO:2000425)3.61794875
115fructose metabolic process (GO:0006000)3.61596619
116regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.58608498
117glutamate metabolic process (GO:0006536)3.58506146
118terpenoid biosynthetic process (GO:0016114)3.55261204
119aspartate family amino acid catabolic process (GO:0009068)3.54105522
120negative regulation of lipase activity (GO:0060192)3.53777037
121ketone body metabolic process (GO:1902224)3.51846862
122indole-containing compound metabolic process (GO:0042430)3.51759723
123complement activation, alternative pathway (GO:0006957)3.51558759
124cytoplasmic microtubule organization (GO:0031122)3.50225638
125arginine metabolic process (GO:0006525)3.50002371
126organic acid catabolic process (GO:0016054)3.49369703
127carboxylic acid catabolic process (GO:0046395)3.49369703
128negative regulation of inclusion body assembly (GO:0090084)3.48151321
129regulation of protein activation cascade (GO:2000257)3.47811883
130cellular glucuronidation (GO:0052695)3.47081845
131cardiovascular system development (GO:0072358)3.46823639
132dicarboxylic acid biosynthetic process (GO:0043650)3.43020905
133nucleoside diphosphate phosphorylation (GO:0006165)3.40179459
134plasma lipoprotein particle clearance (GO:0034381)3.39088146
135sperm motility (GO:0030317)3.37592666
136CDP-diacylglycerol metabolic process (GO:0046341)3.37541846
137establishment of apical/basal cell polarity (GO:0035089)3.37340143
138positive regulation of lipoprotein lipase activity (GO:0051006)3.36760592
139positive regulation of triglyceride lipase activity (GO:0061365)3.36760592
140glomerular epithelial cell development (GO:0072310)3.35264755
141cholesterol efflux (GO:0033344)3.34274520
142imidazole-containing compound metabolic process (GO:0052803)3.33404230
143serine family amino acid metabolic process (GO:0009069)3.32460385
144fatty acid beta-oxidation (GO:0006635)3.29704621
145long-chain fatty acid biosynthetic process (GO:0042759)3.28431981
146smoothened signaling pathway (GO:0007224)3.24529832
147fatty acid oxidation (GO:0019395)3.24460447
148regulation of tolerance induction (GO:0002643)3.23754593
149drug metabolic process (GO:0017144)3.23506123
150low-density lipoprotein particle remodeling (GO:0034374)3.23008834
151phosphatidylethanolamine biosynthetic process (GO:0006646)3.22349932
152regulation of bile acid biosynthetic process (GO:0070857)3.21873105
153determination of left/right symmetry (GO:0007368)3.21031579
154lipid oxidation (GO:0034440)3.19435728
155regulation of complement activation (GO:0030449)3.19415201
156linoleic acid metabolic process (GO:0043651)3.18320759
157monocarboxylic acid catabolic process (GO:0072329)3.16309375
158lipoxygenase pathway (GO:0019372)3.08703132
159microtubule depolymerization (GO:0007019)3.05836192
160determination of bilateral symmetry (GO:0009855)3.04769066
161anatomical structure regression (GO:0060033)3.04023950
162regulation of collateral sprouting (GO:0048670)3.03201006
163digestive tract morphogenesis (GO:0048546)3.02683969
164phosphatidylethanolamine metabolic process (GO:0046337)3.02192394
165natural killer cell activation involved in immune response (GO:0002323)3.01963621
166retinal rod cell development (GO:0046548)3.01859488
167establishment or maintenance of monopolar cell polarity (GO:0061339)3.00040582
168establishment of monopolar cell polarity (GO:0061162)3.00040582
169axonemal dynein complex assembly (GO:0070286)20.2879755
170specification of symmetry (GO:0009799)2.97903528
171microtubule polymerization or depolymerization (GO:0031109)2.96758203
172regulation of autophagic vacuole assembly (GO:2000785)2.90450440
173hydrogen peroxide biosynthetic process (GO:0050665)2.89122832
174primary alcohol metabolic process (GO:0034308)2.87152837
175retinol metabolic process (GO:0042572)2.85425132
176O-glycan processing (GO:0016266)2.81582072
177regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.75997356
178retinal cone cell development (GO:0046549)2.75203533
179negative regulation of adaptive immune response (GO:0002820)2.73981021
180mitochondrion degradation (GO:0000422)2.73456655
181establishment of planar polarity (GO:0001736)2.67868699
182establishment of tissue polarity (GO:0007164)2.67868699
183regulation of smoothened signaling pathway (GO:0008589)2.63925650
184glutathione derivative biosynthetic process (GO:1901687)2.63720474
185glutathione derivative metabolic process (GO:1901685)2.63720474
186photoreceptor cell maintenance (GO:0045494)2.61811238
187calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.58808422
188aldehyde catabolic process (GO:0046185)2.58282865
189lateral sprouting from an epithelium (GO:0060601)2.57932307
190reactive oxygen species biosynthetic process (GO:1903409)2.57868941
191centriole replication (GO:0007099)2.52217355
192cilium movement (GO:0003341)15.5960250
193epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)15.0394822
194motile cilium assembly (GO:0044458)13.8408315
195epithelial cilium movement (GO:0003351)13.1572891

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.36704000
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.05471702
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.65886505
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.17094866
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.16330261
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.37951078
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.36737794
8* DROSHA_22980978_ChIP-Seq_HELA_Human3.32450569
9FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.89719214
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.82845760
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.62754578
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.54264473
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.42316018
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.13231722
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02327981
16GBX2_23144817_ChIP-Seq_PC3_Human1.96705134
17BP1_19119308_ChIP-ChIP_Hs578T_Human1.92482277
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.89685142
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.89650758
20AHR_22903824_ChIP-Seq_MCF-7_Human1.86407648
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.85848320
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.81843050
23SUZ12_27294783_Chip-Seq_NPCs_Mouse1.81532999
24NFE2_27457419_Chip-Seq_LIVER_Mouse1.72589608
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72471154
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71826118
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.69893903
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65435685
29VDR_22108803_ChIP-Seq_LS180_Human1.64523901
30ARNT_22903824_ChIP-Seq_MCF-7_Human1.64244346
31FOXM1_26456572_ChIP-Seq_MCF-7_Human1.59919857
32ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59704404
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56752398
34TP63_23658742_ChIP-Seq_EP156T_Human1.53123592
35FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.50868842
36AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.50098630
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.49006289
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47422832
39ETV1_20927104_ChIP-Seq_GIST48_Human1.46809075
40STAT1_20625510_ChIP-Seq_HELA_Human1.45662323
41SMRT_27268052_Chip-Seq_Bcells_Human1.40127222
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38616730
43TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.36818321
44PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.36361163
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36099965
46CDX2_20551321_ChIP-Seq_CACO-2_Human1.35200553
47PHF8_20622853_ChIP-Seq_HELA_Human1.33801239
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33549991
49KAP1_22055183_ChIP-Seq_ESCs_Mouse1.31908502
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.31873433
51HNFA_21074721_ChIP-Seq_CACO-2_Human1.31596242
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.30903819
53SMAD3_21741376_ChIP-Seq_HESCs_Human1.29570966
54CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29136162
55CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.27148849
56TAF15_26573619_Chip-Seq_HEK293_Human1.25192944
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.25170210
58RUNX1_27514584_Chip-Seq_MCF-7_Human1.23586803
59RUNX1_27457419_Chip-Seq_LIVER_Mouse1.23233957
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22552578
61TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.21261087
62P53_22387025_ChIP-Seq_ESCs_Mouse1.20978155
63GATA6_21074721_ChIP-Seq_CACO-2_Human1.20886515
64TP53_18474530_ChIP-ChIP_U2OS_Human1.20862285
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20798096
66TP63_22573176_ChIP-Seq_HFKS_Human1.20236741
67OCT4_18555785_Chip-Seq_ESCs_Mouse1.20128335
68STAT1_17558387_ChIP-Seq_HELA_Human1.19503808
69OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19249309
70EZH2_22144423_ChIP-Seq_EOC_Human1.18943160
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18864005
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18463234
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.18278222
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.17903780
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17336176
76ESRRB_18555785_Chip-Seq_ESCs_Mouse1.16820365
77HTT_18923047_ChIP-ChIP_STHdh_Human1.16712382
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16135393
79FOXA1_25552417_ChIP-Seq_VCAP_Human1.16069816
80SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15975508
81CRX_20693478_ChIP-Seq_RETINA_Mouse1.15572950
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15518966
83RBPJ_21746931_ChIP-Seq_IB4_Human1.15173627
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14672751
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14552614
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.14550417
87GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.13934857
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12574042
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12073300
90EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11680632
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10317040
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.10211483
93SMC4_20622854_ChIP-Seq_HELA_Human1.09248485
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09214865
95P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08915893
96SALL1_21062744_ChIP-ChIP_HESCs_Human1.08134706
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.07922635
98TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07655833
99P300_18555785_Chip-Seq_ESCs_Mouse1.07272965
100KDM2B_26808549_Chip-Seq_REH_Human1.07176491
101SOX2_20726797_ChIP-Seq_SW620_Human1.06253595
102PU1_27457419_Chip-Seq_LIVER_Mouse1.06141396
103CMYC_18555785_Chip-Seq_ESCs_Mouse1.06048723
104TBL1_22424771_ChIP-Seq_293T_Human1.05796877
105FOXA2_19822575_ChIP-Seq_HepG2_Human1.05777670
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05196285
107ZFX_18555785_Chip-Seq_ESCs_Mouse1.04941294
108NFYB_21822215_ChIP-Seq_K562_Human1.04886010
109FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04859536
110FOXA1_25329375_ChIP-Seq_VCAP_Human1.04859536
111AR_20517297_ChIP-Seq_VCAP_Human1.04059199
112TAL1_26923725_Chip-Seq_HPCs_Mouse1.02787542
113HNF4A_19822575_ChIP-Seq_HepG2_Human1.01997559
114KLF4_18555785_Chip-Seq_ESCs_Mouse1.01906286
115CBX2_22325352_ChIP-Seq_293T-Rex_Human1.01897211
116RUNX2_22187159_ChIP-Seq_PCA_Human1.01778876
117SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01745847
118TCF4_22108803_ChIP-Seq_LS180_Human1.01607196
119SMAD1_18555785_Chip-Seq_ESCs_Mouse1.01321126
120NMYC_18555785_Chip-Seq_ESCs_Mouse1.00973448
121EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00346733
122SOX2_18555785_Chip-Seq_ESCs_Mouse0.99933545
123SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99799719
124TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99394242
125* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99131976
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98483466
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98483466
128CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97777291
129KLF5_25053715_ChIP-Seq_YYC3_Human0.97696322
130NFYA_21822215_ChIP-Seq_K562_Human0.97623569
131P300_19829295_ChIP-Seq_ESCs_Human0.97375601
132CTCF_18555785_Chip-Seq_ESCs_Mouse0.96736169
133CEBPB_22108803_ChIP-Seq_LS180_Human0.96243780
134YY1_22570637_ChIP-Seq_MALME-3M_Human0.95597109
135SMAD4_21799915_ChIP-Seq_A2780_Human0.94831976
136CTCF_20526341_ChIP-Seq_ESCs_Human0.93848718
137FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.93782095
138RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93296387
139ESR2_21235772_ChIP-Seq_MCF-7_Human0.92734129
140MYC_19829295_ChIP-Seq_ESCs_Human0.92585910
141AR_21572438_ChIP-Seq_LNCaP_Human0.92087559
142TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.91896394
143CBP_20019798_ChIP-Seq_JUKART_Human0.91695648
144IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91695648
145TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91559448
146FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91236587
147NCOR_22424771_ChIP-Seq_293T_Human0.90430780
148SMAD4_21741376_ChIP-Seq_HESCs_Human0.89855380
149PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89718985
150CBP_21632823_ChIP-Seq_H3396_Human0.89700164
151GF1_26923725_Chip-Seq_HPCs_Mouse0.89579661
152JARID2_20075857_ChIP-Seq_MESCs_Mouse0.89161193
153UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88929430
154CBX2_27304074_Chip-Seq_ESCs_Mouse0.88752004
155RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87226958
156PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85976997
157CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85668876
158NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85437638
159POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84336793
160STAT3_23295773_ChIP-Seq_U87_Human0.83004296
161* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.82396035
162RNF2_27304074_Chip-Seq_NSC_Mouse0.82016110
163SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.80335178
164MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80282518
165MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80186971
166CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.79348819
167PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78232931
168LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.78177101
169SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.77779352
170ER_23166858_ChIP-Seq_MCF-7_Human0.77245483
171BCAT_22108803_ChIP-Seq_LS180_Human0.76828728
172ESET_19884257_ChIP-Seq_ESCs_Mouse0.76790377
173SMAD3_21741376_ChIP-Seq_EPCs_Human0.76329738
174LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.75464508
175TCF4_23295773_ChIP-Seq_U87_Human0.75111807
176CDX2_22108803_ChIP-Seq_LS180_Human0.74270142
177ELK4_26923725_Chip-Seq_MESODERM_Mouse0.74091519

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.74556805
2MP0002653_abnormal_ependyma_morphology6.98517349
3MP0005360_urolithiasis6.66027993
4MP0005365_abnormal_bile_salt5.84192818
5MP0005085_abnormal_gallbladder_physiolo5.70414753
6MP0004133_heterotaxia5.42601710
7MP0008875_abnormal_xenobiotic_pharmacok4.39850691
8MP0003252_abnormal_bile_duct4.11552116
9MP0003195_calcinosis3.79296324
10MP0005410_abnormal_fertilization3.14373963
11MP0004019_abnormal_vitamin_homeostasis3.13892709
12MP0002877_abnormal_melanocyte_morpholog3.02686299
13MP0010329_abnormal_lipoprotein_level2.92656157
14MP0005332_abnormal_amino_acid2.92382243
15MP0005408_hypopigmentation2.59884886
16MP0008789_abnormal_olfactory_epithelium2.50376199
17MP0005623_abnormal_meninges_morphology2.40423474
18MP0003806_abnormal_nucleotide_metabolis2.26265465
19MP0009780_abnormal_chondrocyte_physiolo2.25792979
20MP0008995_early_reproductive_senescence2.24279625
21MP0002138_abnormal_hepatobiliary_system2.19839646
22MP0005083_abnormal_biliary_tract2.07371449
23MP0003191_abnormal_cellular_cholesterol1.99551963
24MP0009697_abnormal_copulation1.97358162
25MP0005670_abnormal_white_adipose1.89088683
26MP0002118_abnormal_lipid_homeostasis1.84987122
27MP0005451_abnormal_body_composition1.84407689
28MP0001666_abnormal_nutrient_absorption1.80511507
29MP0000383_abnormal_hair_follicle1.79819363
30MP0003868_abnormal_feces_composition1.79149951
31MP0000462_abnormal_digestive_system1.77223031
32MP0002282_abnormal_trachea_morphology1.75539292
33MP0001270_distended_abdomen1.74767306
34MP0009840_abnormal_foam_cell1.72818276
35MP0000609_abnormal_liver_physiology1.69143970
36MP0004043_abnormal_pH_regulation1.68831462
37MP0002876_abnormal_thyroid_physiology1.67250313
38MP0000631_abnormal_neuroendocrine_gland1.67049928
39MP0000566_synostosis1.62287751
40MP0005647_abnormal_sex_gland1.57092022
41MP0001764_abnormal_homeostasis1.56898490
42MP0009643_abnormal_urine_homeostasis1.55931579
43MP0005319_abnormal_enzyme/_coenzyme1.54911727
44MP0003011_delayed_dark_adaptation1.53397539
45MP0005389_reproductive_system_phenotype1.52148861
46MP0005499_abnormal_olfactory_system1.49710110
47MP0005394_taste/olfaction_phenotype1.49710110
48MP0002160_abnormal_reproductive_system1.45880499
49MP0009764_decreased_sensitivity_to1.43586458
50MP0010678_abnormal_skin_adnexa1.39745245
51MP0005636_abnormal_mineral_homeostasis1.38905396
52MP0005646_abnormal_pituitary_gland1.27427109
53MP0001765_abnormal_ion_homeostasis1.26175276
54MP0005584_abnormal_enzyme/coenzyme_acti1.25416437
55MP0005187_abnormal_penis_morphology1.23593347
56MP0002928_abnormal_bile_duct1.21436771
57MP0003186_abnormal_redox_activity1.19639691
58MP0002909_abnormal_adrenal_gland1.16976315
59MP0003698_abnormal_male_reproductive1.16592891
60MP0004782_abnormal_surfactant_physiolog1.16073852
61MP0003303_peritoneal_inflammation1.13031416
62MP0002735_abnormal_chemical_nociception1.11305098
63MP0002638_abnormal_pupillary_reflex1.11060562
64MP0006292_abnormal_olfactory_placode1.04669033
65MP0001919_abnormal_reproductive_system1.02914247
66MP0002136_abnormal_kidney_physiology0.99701986
67MP0001346_abnormal_lacrimal_gland0.96351891
68MP0005387_immune_system_phenotype0.96109245
69MP0001790_abnormal_immune_system0.96109245
70MP0002254_reproductive_system_inflammat0.96027577
71MP0005551_abnormal_eye_electrophysiolog0.94642940
72MP0005381_digestive/alimentary_phenotyp0.94570688
73MP0001756_abnormal_urination0.92941941
74MP0005257_abnormal_intraocular_pressure0.92881395
75MP0004883_abnormal_blood_vessel0.92459859
76MP0005377_hearing/vestibular/ear_phenot0.91853662
77MP0003878_abnormal_ear_physiology0.91853662
78MP0005253_abnormal_eye_physiology0.90538860
79MP0009046_muscle_twitch0.87978544
80MP0003866_abnormal_defecation0.87882850
81MP0009703_decreased_birth_body0.87698119
82MP0001929_abnormal_gametogenesis0.87663770
83MP0005084_abnormal_gallbladder_morpholo0.87390316
84MP0001485_abnormal_pinna_reflex0.86564753
85MP0003136_yellow_coat_color0.86384127
86MP0010155_abnormal_intestine_physiology0.84267702
87MP0002168_other_aberrant_phenotype0.82674542
88MP0005165_increased_susceptibility_to0.81522288
89MP0009642_abnormal_blood_homeostasis0.81414543
90MP0001944_abnormal_pancreas_morphology0.81241130
91MP0002734_abnormal_mechanical_nocicepti0.80560488
92MP0005535_abnormal_body_temperature0.79632851
93MP0008469_abnormal_protein_level0.76789109
94MP0000598_abnormal_liver_morphology0.73989427
95MP0000678_abnormal_parathyroid_gland0.73633921
96MP0002277_abnormal_respiratory_mucosa0.72668223
97MP0005164_abnormal_response_to0.72588971
98MP0002405_respiratory_system_inflammati0.72353357
99MP0002249_abnormal_larynx_morphology0.72204246
100MP0002078_abnormal_glucose_homeostasis0.71661157
101MP0003315_abnormal_perineum_morphology0.66422667
102MP0000465_gastrointestinal_hemorrhage0.65659323
103MP0002971_abnormal_brown_adipose0.65577499
104MP0002233_abnormal_nose_morphology0.64828709
105MP0005395_other_phenotype0.64263732
106MP0009763_increased_sensitivity_to0.64076456
107MP0002161_abnormal_fertility/fecundity0.63846752
108MP0009379_abnormal_foot_pigmentation0.60607063
109MP0003879_abnormal_hair_cell0.59419864
110MP0005334_abnormal_fat_pad0.59177853
111MP0008004_abnormal_stomach_pH0.59152577
112MP0001835_abnormal_antigen_presentation0.58821329
113MP0002132_abnormal_respiratory_system0.58470979
114MP0003690_abnormal_glial_cell0.57553872
115MP0003953_abnormal_hormone_level0.56380363
116MP0006082_CNS_inflammation0.54307086
117MP0005248_abnormal_Harderian_gland0.53874824
118MP0005379_endocrine/exocrine_gland_phen0.53579718
119MP0001663_abnormal_digestive_system0.53483936
120MP0002102_abnormal_ear_morphology0.53177856
121MP0003119_abnormal_digestive_system0.52508317
122MP0002210_abnormal_sex_determination0.51506501
123MP0003656_abnormal_erythrocyte_physiolo0.51318829
124MP0004742_abnormal_vestibular_system0.50816536
125MP0009765_abnormal_xenobiotic_induced0.50657711
126MP0002135_abnormal_kidney_morphology0.50448333
127MP0000371_diluted_coat_color0.49943434
128MP0005220_abnormal_exocrine_pancreas0.49039836
129MP0001984_abnormal_olfaction0.48771243
130MP0002095_abnormal_skin_pigmentation0.48769943
131MP0000026_abnormal_inner_ear0.47311506
132MP0000230_abnormal_systemic_arterial0.46890973
133MP0009115_abnormal_fat_cell0.46093783
134MP0005376_homeostasis/metabolism_phenot0.45760343
135MP0003724_increased_susceptibility_to0.45456119
136MP0005310_abnormal_salivary_gland0.44528915
137MP0001664_abnormal_digestion0.43597512
138MP0005666_abnormal_adipose_tissue0.43437872
139MP0008874_decreased_physiological_sensi0.42753106
140MP0006036_abnormal_mitochondrial_physio0.42201767
141MP0005391_vision/eye_phenotype0.40907559
142MP0001970_abnormal_pain_threshold0.40857406
143MP0005195_abnormal_posterior_eye0.40277289
144MP0001145_abnormal_male_reproductive0.40262210
145MP0003942_abnormal_urinary_system0.40191966
146MP0000653_abnormal_sex_gland0.39936796
147MP0001324_abnormal_eye_pigmentation0.39264698
148MP0008569_lethality_at_weaning0.39178871
149MP0001661_extended_life_span0.38875807
150MP0001986_abnormal_taste_sensitivity0.38319806
151MP0005645_abnormal_hypothalamus_physiol0.38126110
152MP0000681_abnormal_thyroid_gland0.37779433
153MP0000639_abnormal_adrenal_gland0.37697278
154MP0004381_abnormal_hair_follicle0.36999395
155MP0003718_maternal_effect0.36966179
156MP0004264_abnormal_extraembryonic_tissu0.36542432
157MP0001486_abnormal_startle_reflex0.36041582
158MP0001502_abnormal_circadian_rhythm0.34703960
159MP0008872_abnormal_physiological_respon0.33933830
160MP0002572_abnormal_emotion/affect_behav0.33629977
161MP0003075_altered_response_to0.33417448
162MP0001119_abnormal_female_reproductive0.32691635
163MP0008961_abnormal_basal_metabolism0.32611673
164MP0006035_abnormal_mitochondrial_morpho0.32438326

Predicted human phenotypes

RankGene SetZ-score
1Bronchiectasis (HP:0002110)7.18392234
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.48134076
3Abnormality of the nasal mucosa (HP:0000433)5.35981016
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.81198282
5Absent/shortened dynein arms (HP:0200106)4.76283747
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.76283747
7Intrahepatic cholestasis (HP:0001406)4.66289318
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.57023780
9Recurrent sinusitis (HP:0011108)4.48951481
10Prolonged partial thromboplastin time (HP:0003645)4.46464069
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.45578320
12Deep venous thrombosis (HP:0002625)4.40505707
13Bronchitis (HP:0012387)4.31804536
14Xanthomatosis (HP:0000991)4.10909025
15Chronic sinusitis (HP:0011109)4.09261166
16Joint hemorrhage (HP:0005261)4.08155231
17Infertility (HP:0000789)4.07511732
18Abnormal respiratory motile cilium physiology (HP:0012261)3.96628357
19Hyperglycinuria (HP:0003108)3.93681853
20Hypobetalipoproteinemia (HP:0003563)3.89983254
21Abnormal ciliary motility (HP:0012262)3.86712239
22Hyperlipoproteinemia (HP:0010980)3.78997772
23Hyperglycinemia (HP:0002154)3.76268470
24Male infertility (HP:0003251)3.75944031
25Recurrent otitis media (HP:0000403)3.71838681
26Ketosis (HP:0001946)3.65973783
27Hyperammonemia (HP:0001987)3.60592237
28Abnormality of glycine metabolism (HP:0010895)3.57907867
29Abnormality of serine family amino acid metabolism (HP:0010894)3.57907867
30Pancreatic fibrosis (HP:0100732)3.55955554
31Abnormal respiratory epithelium morphology (HP:0012253)3.51484187
32Abnormal respiratory motile cilium morphology (HP:0005938)3.51484187
33Vascular calcification (HP:0004934)3.47681423
34True hermaphroditism (HP:0010459)3.47512466
35Occipital encephalocele (HP:0002085)3.40768053
36Hyperactive renin-angiotensin system (HP:0000841)3.40031388
37Abnormality of aspartate family amino acid metabolism (HP:0010899)3.33019131
38Conjugated hyperbilirubinemia (HP:0002908)3.29187318
39Abnormality of pyrimidine metabolism (HP:0004353)3.25051001
40Atelectasis (HP:0100750)3.21717261
41Gout (HP:0001997)3.16638894
42Alkalosis (HP:0001948)3.15084796
43Abnormality of nucleobase metabolism (HP:0010932)3.11415701
44Chronic otitis media (HP:0000389)3.10648745
45Abnormality of sulfur amino acid metabolism (HP:0004339)3.06131557
46Abnormality of purine metabolism (HP:0004352)3.04598051
47Hypolipoproteinemia (HP:0010981)3.03914898
48Abnormality of proline metabolism (HP:0010907)3.03831173
49Hydroxyprolinuria (HP:0003080)3.03831173
50Rhinitis (HP:0012384)3.02601675
51Hypoalphalipoproteinemia (HP:0003233)3.01739009
52Molar tooth sign on MRI (HP:0002419)3.00943870
53Abnormality of midbrain morphology (HP:0002418)3.00943870
54Cardiovascular calcification (HP:0011915)3.00704318
55Pancreatic cysts (HP:0001737)2.97296349
56Epidermoid cyst (HP:0200040)2.95029127
57Complement deficiency (HP:0004431)2.90994171
58Abnormality of chloride homeostasis (HP:0011422)2.89824868
59Nephronophthisis (HP:0000090)2.87553311
60Abnormality of fatty-acid metabolism (HP:0004359)2.86467852
61Abnormality of renal excretion (HP:0011036)2.84173616
62Cystic liver disease (HP:0006706)2.83513776
63Abnormality of methionine metabolism (HP:0010901)2.81216755
64Fat malabsorption (HP:0002630)2.81109043
65Metabolic alkalosis (HP:0200114)2.80662183
66Proximal tubulopathy (HP:0000114)2.77089462
67Enlarged kidneys (HP:0000105)2.74500789
68Ketoacidosis (HP:0001993)2.74337497
69Abnormal urine output (HP:0012590)2.74119493
70Metabolic acidosis (HP:0001942)2.71312315
71Bile duct proliferation (HP:0001408)2.71310963
72Abnormal biliary tract physiology (HP:0012439)2.71310963
73Polyuria (HP:0000103)2.70622249
74Increased circulating renin level (HP:0000848)2.70473214
75Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.69156111
76Hypoglycemic coma (HP:0001325)2.67821886
77Hypokalemic alkalosis (HP:0001949)2.62426305
78Delayed CNS myelination (HP:0002188)2.62188782
79Hyperuricemia (HP:0002149)2.60090827
80Increased purine levels (HP:0004368)2.60090827
81Chronic bronchitis (HP:0004469)2.57909707
82Hypercholesterolemia (HP:0003124)2.56758575
83Tetany (HP:0001281)2.54644383
84Abnormal drinking behavior (HP:0030082)2.53589214
85Polydipsia (HP:0001959)2.53589214
86Abnormality of the intrinsic pathway (HP:0010989)2.45874899
87Hypomagnesemia (HP:0002917)2.44718183
88Hypoglycemic seizures (HP:0002173)2.44409058
89Renal cortical cysts (HP:0000803)2.44374287
90Rickets (HP:0002748)2.41124450
91Hyperventilation (HP:0002883)2.38772590
92Abnormality of serum amino acid levels (HP:0003112)2.38627468
93Postaxial foot polydactyly (HP:0001830)2.38332326
94Recurrent bronchitis (HP:0002837)2.36423421
95Hypochromic microcytic anemia (HP:0004840)2.34355317
96Chronic hepatic failure (HP:0100626)2.31699015
97Hyperaldosteronism (HP:0000859)2.31615000
98Abnormality of dicarboxylic acid metabolism (HP:0010995)2.29562293
99Dicarboxylic aciduria (HP:0003215)2.29562293
100Abnormality of renin-angiotensin system (HP:0000847)2.29273001
101Hyperbilirubinemia (HP:0002904)2.28844387
102Abnormality of the renal cortex (HP:0011035)2.28229022
103Abnormality of the renal medulla (HP:0100957)2.28024123
104Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.25464934
105Malnutrition (HP:0004395)2.21099018
106Steatorrhea (HP:0002570)2.19749173
107Abnormality of the common coagulation pathway (HP:0010990)2.18078040
108Aplasia/Hypoplasia of the tongue (HP:0010295)2.15850913
109Generalized aminoaciduria (HP:0002909)2.15180444
110Systemic lupus erythematosus (HP:0002725)2.09933169
111Congenital hepatic fibrosis (HP:0002612)2.09292846
112Mitral stenosis (HP:0001718)2.08778884
113Hyperinsulinemic hypoglycemia (HP:0000825)2.08767353
114Abnormal enzyme/coenzyme activity (HP:0012379)2.07139925
115Male pseudohermaphroditism (HP:0000037)2.06352456
116Myocardial infarction (HP:0001658)2.01526867
117Hemorrhage of the eye (HP:0011885)1.99548335
118Nasal polyposis (HP:0100582)1.98936379
119Absent frontal sinuses (HP:0002688)1.98886219
120Tubulointerstitial nephritis (HP:0001970)1.98735402
121Abnormality of complement system (HP:0005339)1.98726658
122Anencephaly (HP:0002323)1.97176288
123Pancreatitis (HP:0001733)1.97071444
124Medial flaring of the eyebrow (HP:0010747)1.96324233
125Tubulointerstitial abnormality (HP:0001969)1.94890824
126Asplenia (HP:0001746)1.94618315
127Symptomatic seizures (HP:0011145)1.93811901
128Elevated alkaline phosphatase (HP:0003155)1.93076127
129Aplasia/Hypoplasia of the spleen (HP:0010451)1.92210420
130Decreased circulating renin level (HP:0003351)1.85496211
131Furrowed tongue (HP:0000221)1.80779503
132Bell-shaped thorax (HP:0001591)1.78822451
133Tubular atrophy (HP:0000092)1.76171566
134Congenital primary aphakia (HP:0007707)1.74711805
135Renal salt wasting (HP:0000127)1.72624093
136Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72566694
137Gait imbalance (HP:0002141)1.70871030
138Neoplasm of the heart (HP:0100544)1.65331306
139Sclerocornea (HP:0000647)1.63324927
140Nephropathy (HP:0000112)1.60810190
141Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.59455808
142Oculomotor apraxia (HP:0000657)1.57909893
143Postaxial hand polydactyly (HP:0001162)1.54146046
144Nephrogenic diabetes insipidus (HP:0009806)1.50622048
145Decreased central vision (HP:0007663)1.44355777
146Abnormality of the frontal sinuses (HP:0002687)1.37927254
147Hyperkalemia (HP:0002153)1.37774204
148Abnormal delayed hypersensitivity skin test (HP:0002963)1.33908567
149Abnormal rod and cone electroretinograms (HP:0008323)1.29265865
150Median cleft lip (HP:0000161)1.27992408
151Abnormality of permanent molar morphology (HP:0011071)1.27302211
152Abnormality of the dental root (HP:0006486)1.27302211
153Taurodontia (HP:0000679)1.27302211
154Preaxial hand polydactyly (HP:0001177)1.26861502
155Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.25742112
156Genital tract atresia (HP:0001827)1.18300147
157Vaginal atresia (HP:0000148)1.18208263
158Cone-rod dystrophy (HP:0000548)1.18160007
159Short nail (HP:0001799)1.17544594
160Abnormality of molar (HP:0011077)1.16486152
161Abnormality of molar morphology (HP:0011070)1.16486152
162Abnormality of the dental pulp (HP:0006479)1.16076903
163Short thorax (HP:0010306)1.15778499
164Stage 5 chronic kidney disease (HP:0003774)1.13763298
165Poor coordination (HP:0002370)1.12356896
166Supernumerary spleens (HP:0009799)1.10509816
167Generalized hypopigmentation of hair (HP:0011358)1.09131901
168Fetal akinesia sequence (HP:0001989)1.06627901
169Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.06272877
170Elevated erythrocyte sedimentation rate (HP:0003565)1.02212884
171Hip dysplasia (HP:0001385)1.01702144
172Retinitis pigmentosa (HP:0000510)1.01641391
173Abnormality of macular pigmentation (HP:0008002)1.01399664
174Abnormality of the distal phalanges of the toes (HP:0010182)1.01258652
175Nonprogressive disorder (HP:0003680)1.01050453
176Tubulointerstitial fibrosis (HP:0005576)1.00265964
177Hyponatremia (HP:0002902)0.99535253

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.86103367
2STK244.21602581
3TAF13.55192361
4BCKDK3.38298904
5EPHA23.37048394
6SIK13.33313737
7SIK33.27456428
8WNK43.18661313
9PRKCI2.99692960
10WNK32.97456264
11INSRR2.91452060
12STK38L2.68060471
13PDK32.63326394
14PDK42.63326394
15MAP3K142.27131341
16CASK2.25585161
17OXSR12.06707563
18PDK22.04556372
19PINK12.01820564
20MAPK151.94190982
21ADRBK21.93035269
22GRK11.87435204
23NME11.86702844
24IRAK31.82439237
25TGFBR21.82178949
26ERN11.81909690
27TLK11.81298097
28SGK21.79846868
29TAOK31.70728189
30MAP3K51.69692172
31MAPKAPK31.61120251
32FGFR41.58845876
33CDK121.57659412
34STK381.52503820
35LATS11.51807651
36SIK21.45287701
37BCR1.37773234
38MAP2K41.36379225
39PIK3CG1.35329176
40MAP3K21.34121760
41SGK2231.33002500
42SGK4941.33002500
43SGK31.25107274
44MAPK71.25056788
45ERBB41.24632256
46PNCK1.20545451
47STK391.19998536
48WNK11.14047540
49TEC1.11556941
50GRK71.11444583
51MST1R1.07315845
52ITK1.07156128
53GRK51.05833236
54ERBB21.05748938
55PRKAA21.04781852
56FRK1.02552908
57TTK1.00057476
58MATK0.99339271
59IRAK10.98584825
60EIF2AK20.97843863
61AKT30.97223647
62MAP2K70.92619234
63MAP2K60.91179030
64BLK0.90550290
65TXK0.89840487
66STK100.88790189
67PRKD30.85117155
68CDK80.81115469
69NEK60.79658787
70CDK30.77580902
71PRKAA10.77381358
72MAP4K20.75598245
73ZAK0.75235577
74JAK30.75195980
75CAMK40.74958841
76TNK20.74736322
77STK160.74730972
78RIPK40.74425604
79GRK60.73932373
80PRKCG0.72360200
81MAPK110.71716452
82EPHA30.71242691
83YES10.69571753
84MARK30.67228720
85BRSK20.65853947
86CSF1R0.65203827
87TRPM70.63560641
88TESK10.61688429
89DYRK1B0.60775763
90ERBB30.60711813
91TIE10.60572393
92PTK2B0.59933423
93TNIK0.58733913
94EPHB10.57813839
95PRKCZ0.57500904
96MUSK0.54118545
97STK30.53698316
98NUAK10.52253158
99DAPK20.50577869
100PRPF4B0.49789353
101MAPK40.49568369
102EPHA40.49350565
103CHUK0.47441714
104CAMK1D0.46711534
105PRKACG0.46149834
106SMG10.44737872
107CAMK1G0.44499332
108MAPK120.43618043
109KIT0.43467712
110CAMKK10.43392050
111MARK20.43091120
112FLT30.43057051
113RPS6KA20.42377815
114IKBKE0.42367036
115MAPK130.42009115
116ABL20.41667126
117ADRBK10.41323861
118EEF2K0.41269485
119MAP3K70.41102377
120ICK0.40639090
121CSK0.40393941
122JAK10.40174663
123NTRK30.39333363
124IRAK20.39237383
125GSK3A0.39161092
126PRKCQ0.39106618
127BTK0.38703376
128BMPR1B0.38004317
129MAP3K40.37633623
130MAP3K30.37621014
131NLK0.37552480
132PRKACA0.37535540
133LRRK20.37079828
134CAMK10.36903816
135PRKCD0.36255898
136IGF1R0.35939302
137IKBKB0.35923251
138NEK90.35699922
139TBK10.34757285
140SGK10.33956437
141ABL10.29969423
142ROCK20.29712913
143AURKA0.28941311
144CAMK2A0.25040235
145PRKCA0.24703635
146ACVR1B0.23511512
147LYN0.23243908
148HIPK20.21662677
149FYN0.21435387
150CAMKK20.19753678
151BMPR20.18894812
152PRKG10.18419970
153OBSCN0.18088953
154MAP2K20.17800208
155CAMK2G0.17747340
156ROCK10.17326400
157TYK20.16976007
158TAOK10.15367744
159EGFR0.15248951
160PRKCE0.14559176

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.78340674
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31563523
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.10109013
4Tryptophan metabolism_Homo sapiens_hsa003802.85922122
5Huntingtons disease_Homo sapiens_hsa050162.81580803
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.70858715
7Fatty acid degradation_Homo sapiens_hsa000712.69443859
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.53781210
9Arginine biosynthesis_Homo sapiens_hsa002202.51666823
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.50291661
11Butanoate metabolism_Homo sapiens_hsa006502.44410572
12Peroxisome_Homo sapiens_hsa041462.40726367
13Propanoate metabolism_Homo sapiens_hsa006402.39614788
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.33897811
15Complement and coagulation cascades_Homo sapiens_hsa046102.26195343
16Nitrogen metabolism_Homo sapiens_hsa009102.24198807
17Steroid hormone biosynthesis_Homo sapiens_hsa001402.11384687
18PPAR signaling pathway_Homo sapiens_hsa033202.10723222
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.06168166
20beta-Alanine metabolism_Homo sapiens_hsa004102.05230980
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05159112
22Fatty acid metabolism_Homo sapiens_hsa012121.99545645
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.98989392
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.96030076
25Histidine metabolism_Homo sapiens_hsa003401.95970441
26Chemical carcinogenesis_Homo sapiens_hsa052041.94416622
27Retinol metabolism_Homo sapiens_hsa008301.77578804
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.75579350
29Hedgehog signaling pathway_Homo sapiens_hsa043401.75422355
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71173161
31Pyruvate metabolism_Homo sapiens_hsa006201.63966628
32Bile secretion_Homo sapiens_hsa049761.53515278
33Selenocompound metabolism_Homo sapiens_hsa004501.48358841
34Vitamin B6 metabolism_Homo sapiens_hsa007501.47705500
35Basal cell carcinoma_Homo sapiens_hsa052171.46992267
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.46780432
37Staphylococcus aureus infection_Homo sapiens_hsa051501.46034042
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.44825786
39Sphingolipid metabolism_Homo sapiens_hsa006001.44817682
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43220335
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40504730
42ABC transporters_Homo sapiens_hsa020101.38697332
43Phenylalanine metabolism_Homo sapiens_hsa003601.36469863
44Asthma_Homo sapiens_hsa053101.34290745
45Vitamin digestion and absorption_Homo sapiens_hsa049771.30285197
46Fatty acid elongation_Homo sapiens_hsa000621.29213919
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.28328889
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.22957049
49Starch and sucrose metabolism_Homo sapiens_hsa005001.22910903
50Sulfur metabolism_Homo sapiens_hsa009201.22001161
51Graft-versus-host disease_Homo sapiens_hsa053321.18288752
52Tyrosine metabolism_Homo sapiens_hsa003501.16071023
53Allograft rejection_Homo sapiens_hsa053301.15686848
54Lysine degradation_Homo sapiens_hsa003101.12933080
55Type I diabetes mellitus_Homo sapiens_hsa049401.12639910
56Autoimmune thyroid disease_Homo sapiens_hsa053201.12297750
57Maturity onset diabetes of the young_Homo sapiens_hsa049501.06309914
58Salivary secretion_Homo sapiens_hsa049701.05495180
59Intestinal immune network for IgA production_Homo sapiens_hsa046721.04388317
60Arginine and proline metabolism_Homo sapiens_hsa003300.98432160
61Olfactory transduction_Homo sapiens_hsa047400.98065916
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95875293
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94219066
64Glycerolipid metabolism_Homo sapiens_hsa005610.91920330
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.91623450
66Carbon metabolism_Homo sapiens_hsa012000.90702177
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88508050
68Phototransduction_Homo sapiens_hsa047440.88427327
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87104587
70Hematopoietic cell lineage_Homo sapiens_hsa046400.86108183
71Folate biosynthesis_Homo sapiens_hsa007900.86016710
72Steroid biosynthesis_Homo sapiens_hsa001000.85624922
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85133509
74Notch signaling pathway_Homo sapiens_hsa043300.84339108
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84263281
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83752129
77Fatty acid biosynthesis_Homo sapiens_hsa000610.82830395
78Fat digestion and absorption_Homo sapiens_hsa049750.81297610
79Tight junction_Homo sapiens_hsa045300.78270704
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71110113
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70328697
82Biosynthesis of amino acids_Homo sapiens_hsa012300.69248978
83Glutathione metabolism_Homo sapiens_hsa004800.67359833
84cAMP signaling pathway_Homo sapiens_hsa040240.65077628
85Caffeine metabolism_Homo sapiens_hsa002320.61162773
86Fructose and mannose metabolism_Homo sapiens_hsa000510.57585605
87Hepatitis C_Homo sapiens_hsa051600.57143642
88Serotonergic synapse_Homo sapiens_hsa047260.57044784
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56048295
90Circadian rhythm_Homo sapiens_hsa047100.54218233
91Antigen processing and presentation_Homo sapiens_hsa046120.53397230
92Linoleic acid metabolism_Homo sapiens_hsa005910.52010001
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51489693
94Metabolic pathways_Homo sapiens_hsa011000.48343390
95Rheumatoid arthritis_Homo sapiens_hsa053230.45007185
96Pentose phosphate pathway_Homo sapiens_hsa000300.43123824
97Arachidonic acid metabolism_Homo sapiens_hsa005900.43092087
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.42514399
99One carbon pool by folate_Homo sapiens_hsa006700.41800452
100Choline metabolism in cancer_Homo sapiens_hsa052310.41106337
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.39870544
102Sulfur relay system_Homo sapiens_hsa041220.36278752
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33039379
104Mineral absorption_Homo sapiens_hsa049780.31150357
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.29336164
106Calcium signaling pathway_Homo sapiens_hsa040200.29179011
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28820250
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.26939590
109Pancreatic secretion_Homo sapiens_hsa049720.25843088
110Ovarian steroidogenesis_Homo sapiens_hsa049130.22384539
111Galactose metabolism_Homo sapiens_hsa000520.22299036
112Herpes simplex infection_Homo sapiens_hsa051680.20754587
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20664755
114Glucagon signaling pathway_Homo sapiens_hsa049220.20569360
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.19161922
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17591297
117Homologous recombination_Homo sapiens_hsa034400.16887562
118Lysosome_Homo sapiens_hsa041420.16071769
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15792340
120Phagosome_Homo sapiens_hsa041450.15283625
121Other glycan degradation_Homo sapiens_hsa005110.14318228
122Cocaine addiction_Homo sapiens_hsa050300.13668707
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.12708938
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.12315115
125Insulin resistance_Homo sapiens_hsa049310.09562702
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.09250533
127Ether lipid metabolism_Homo sapiens_hsa005650.05560521
128Taste transduction_Homo sapiens_hsa047420.02883941
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.02773202
130African trypanosomiasis_Homo sapiens_hsa051430.01079952
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.00227009
132Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0984238
133AMPK signaling pathway_Homo sapiens_hsa04152-0.0872264
134Nicotine addiction_Homo sapiens_hsa05033-0.0748698
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0632717
136Prion diseases_Homo sapiens_hsa05020-0.0616738
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0565108
138Regulation of autophagy_Homo sapiens_hsa04140-0.0379286
139Collecting duct acid secretion_Homo sapiens_hsa04966-0.0300126
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0298898
141Protein digestion and absorption_Homo sapiens_hsa04974-0.0217154
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0201782

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