ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	4.26841413
2	DNA deamination (GO:0045006)	4.21065493
3	synapsis (GO:0007129)	4.05429592
4	behavioral response to nicotine (GO:0035095)	3.88660647
5	replication fork processing (GO:0031297)	3.56654870
6	tryptophan catabolic process (GO:0006569)	3.51607699
7	indole-containing compound catabolic process (GO:0042436)	3.51607699
8	indolalkylamine catabolic process (GO:0046218)	3.51607699
9	protein complex biogenesis (GO:0070271)	3.50710930
10	maturation of 5.8S rRNA (GO:0000460)	3.48360392
11	fucose catabolic process (GO:0019317)	3.44504269
12	L-fucose metabolic process (GO:0042354)	3.44504269
13	L-fucose catabolic process (GO:0042355)	3.44504269
14	mitochondrial respiratory chain complex assembly (GO:0033108)	3.44461229
15	indolalkylamine metabolic process (GO:0006586)	3.38085925
16	DNA double-strand break processing (GO:0000729)	3.37816697
17	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.36765400
18	NADH dehydrogenase complex assembly (GO:0010257)	3.36765400
19	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.36765400
20	male meiosis I (GO:0007141)	3.31932284
21	pseudouridine synthesis (GO:0001522)	3.29293857
22	respiratory chain complex IV assembly (GO:0008535)	3.29209402
23	protein prenylation (GO:0018342)	3.28483660
24	prenylation (GO:0097354)	3.28483660
25	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.27366599
26	double-strand break repair via homologous recombination (GO:0000724)	3.24915377
27	recombinational repair (GO:0000725)	3.23131764
28	reciprocal DNA recombination (GO:0035825)	3.21153961
29	reciprocal meiotic recombination (GO:0007131)	3.21153961
30	tryptophan metabolic process (GO:0006568)	3.20787449
31	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.20139901
32	kynurenine metabolic process (GO:0070189)	3.17736143
33	male meiosis (GO:0007140)	3.17391929
34	rRNA modification (GO:0000154)	3.16081428
35	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.14883137
36	water-soluble vitamin biosynthetic process (GO:0042364)	3.10556423
37	cellular ketone body metabolic process (GO:0046950)	3.09883575
38	protein-cofactor linkage (GO:0018065)	3.08994979
39	cytochrome complex assembly (GO:0017004)	3.06660278
40	preassembly of GPI anchor in ER membrane (GO:0016254)	3.04721223
41	response to pheromone (GO:0019236)	3.04565400
42	rRNA methylation (GO:0031167)	3.04362079
43	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.03191652
44	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.01092177
45	DNA methylation involved in gamete generation (GO:0043046)	2.99827411
46	protein K11-linked deubiquitination (GO:0035871)	2.99304897
47	rRNA catabolic process (GO:0016075)	2.96605843
48	detection of light stimulus involved in visual perception (GO:0050908)	2.96098445
49	detection of light stimulus involved in sensory perception (GO:0050962)	2.96098445
50	centriole replication (GO:0007099)	2.93716456
51	ATP synthesis coupled proton transport (GO:0015986)	2.91059692
52	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.91059692
53	multicellular organism reproduction (GO:0032504)	2.90540063
54	regulation of meiosis I (GO:0060631)	2.89674319
55	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.88348134
56	neural tube formation (GO:0001841)	2.88093952
57	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.85647483
58	meiosis I (GO:0007127)	2.83151503
59	sulfation (GO:0051923)	2.83006923
60	mannosylation (GO:0097502)	2.82093161
61	protein neddylation (GO:0045116)	2.81663520
62	protein K63-linked deubiquitination (GO:0070536)	2.80866862
63	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.79669478
64	ketone body metabolic process (GO:1902224)	2.78755369
65	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.78494427
66	signal peptide processing (GO:0006465)	2.75141352
67	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.74843939
68	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.74843939
69	DNA replication checkpoint (GO:0000076)	2.74572085
70	regulation of mitotic spindle checkpoint (GO:1903504)	2.70744322
71	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.70744322
72	proteasome assembly (GO:0043248)	2.69393160
73	meiotic chromosome segregation (GO:0045132)	2.68466707
74	epithelial cilium movement (GO:0003351)	2.67415168
75	resolution of meiotic recombination intermediates (GO:0000712)	2.66820550
76	termination of RNA polymerase III transcription (GO:0006386)	2.66454540
77	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.66454540
78	ubiquinone biosynthetic process (GO:0006744)	2.66162962
79	protein K6-linked ubiquitination (GO:0085020)	2.66113596
80	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.65197323
81	tRNA processing (GO:0008033)	2.62257642
82	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.60861603
83	chromatin remodeling at centromere (GO:0031055)	2.59897864
84	photoreceptor cell maintenance (GO:0045494)	2.58773656
85	dopamine transport (GO:0015872)	2.56861641
86	base-excision repair, AP site formation (GO:0006285)	2.54756889
87	peptidyl-histidine modification (GO:0018202)	2.53980774
88	histone exchange (GO:0043486)	2.52566316
89	platelet dense granule organization (GO:0060155)	2.51530881
90	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.51377846
91	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.51377846
92	DNA demethylation (GO:0080111)	2.51023167
93	CENP-A containing nucleosome assembly (GO:0034080)	2.50486967
94	mitochondrial RNA metabolic process (GO:0000959)	2.48402198
95	adenosine metabolic process (GO:0046085)	2.46253527
96	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.46163552
97	indole-containing compound metabolic process (GO:0042430)	2.45113210
98	nucleotide transmembrane transport (GO:1901679)	2.45007041
99	oxidative demethylation (GO:0070989)	2.44173080
100	regulation of DNA endoreduplication (GO:0032875)	2.43578750

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.41961352
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.31674476
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.87394112
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.71919261
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.67020597
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.66407749
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.64022941
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.59896561
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.50046442
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.48497119
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.48092355
12	EWS_26573619_Chip-Seq_HEK293_Human	2.40536786
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.36962415
14	GBX2_23144817_ChIP-Seq_PC3_Human	2.29261590
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.26197402
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.20037004
17	FUS_26573619_Chip-Seq_HEK293_Human	2.19153270
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.97807617
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.91548404
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.90948222
21	ELK1_19687146_ChIP-ChIP_HELA_Human	1.90050558
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.88999633
23	EZH2_22144423_ChIP-Seq_EOC_Human	1.86588578
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.86521626
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.86401677
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81465243
27	P300_19829295_ChIP-Seq_ESCs_Human	1.80546846
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.79526404
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.74196068
30	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.70287350
31	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.66218016
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.63708691
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62662433
34	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.60237899
35	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.58480168
36	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.55217021
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.49957326
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.45674846
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.42981667
40	FOXP3_21729870_ChIP-Seq_TREG_Human	1.42837940
41	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.42591184
42	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41172943
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.39648352
44	STAT3_23295773_ChIP-Seq_U87_Human	1.37739187
45	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.36499374
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36342399
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36342399
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.35524824
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.35524824
50	BCAT_22108803_ChIP-Seq_LS180_Human	1.35098477
51	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.31357930
52	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.27929860
53	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.26414764
54	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.25757715
55	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.24958709
56	AR_20517297_ChIP-Seq_VCAP_Human	1.24108756
57	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23659315
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23659315
59	TCF4_23295773_ChIP-Seq_U87_Human	1.23053951
60	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21017633
61	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20408276
62	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19456702
63	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.18464492
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.18339574
65	SMAD4_21799915_ChIP-Seq_A2780_Human	1.18161842
66	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17960934
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.17038998
68	AR_25329375_ChIP-Seq_VCAP_Human	1.16513319
69	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15615994
70	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14269658
71	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.14269658
72	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.12366503
73	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.10222213
74	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10096748
75	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.09321630
76	HOXB7_26014856_ChIP-Seq_BT474_Human	1.08152153
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07092728
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06512173
79	NCOR_22424771_ChIP-Seq_293T_Human	1.06212219
80	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.04662108
81	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.03736568
82	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.03249896
83	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.03077240
84	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.03009066
85	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.02731191
86	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.01544520
87	RUNX2_22187159_ChIP-Seq_PCA_Human	1.01309464
88	GATA3_26560356_Chip-Seq_TH2_Human	1.00808802
89	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.00763290
90	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98803585
91	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.97467334
92	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.96948320
93	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.96751347
94	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96401474
95	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96079955
96	CDX2_22108803_ChIP-Seq_LS180_Human	0.95978561
97	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95959705
98	AR_21572438_ChIP-Seq_LNCaP_Human	0.95075089
99	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.92050760
100	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.91402935

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.61135438
2	MP0003195_calcinosis	2.94178654
3	MP0008057_abnormal_DNA_replication	2.76642097
4	MP0000569_abnormal_digit_pigmentation	2.70941767
5	MP0008058_abnormal_DNA_repair	2.51812543
6	MP0003718_maternal_effect	2.36557231
7	MP0006292_abnormal_olfactory_placode	2.34099239
8	MP0006072_abnormal_retinal_apoptosis	2.28063529
9	MP0005551_abnormal_eye_electrophysiolog	2.20181316
10	MP0002102_abnormal_ear_morphology	2.15608542
11	MP0000372_irregular_coat_pigmentation	1.99435571
12	MP0005410_abnormal_fertilization	1.95418396
13	MP0003693_abnormal_embryo_hatching	1.94224432
14	MP0008872_abnormal_physiological_respon	1.92475208
15	MP0010094_abnormal_chromosome_stability	1.92004306
16	MP0002160_abnormal_reproductive_system	1.86562825
17	MP0002837_dystrophic_cardiac_calcinosis	1.84569230
18	MP0000427_abnormal_hair_cycle	1.83227521
19	MP0001968_abnormal_touch/_nociception	1.81666088
20	MP0008875_abnormal_xenobiotic_pharmacok	1.80717572
21	MP0003646_muscle_fatigue	1.79870289
22	MP0008995_early_reproductive_senescence	1.76694890
23	MP0002163_abnormal_gland_morphology	1.70308963
24	MP0005253_abnormal_eye_physiology	1.68645692
25	MP0003787_abnormal_imprinting	1.68248269
26	MP0005645_abnormal_hypothalamus_physiol	1.67381523
27	MP0002736_abnormal_nociception_after	1.66362325
28	MP0005389_reproductive_system_phenotype	1.65282911
29	MP0009046_muscle_twitch	1.63566680
30	MP0004147_increased_porphyrin_level	1.62750456
31	MP0004142_abnormal_muscle_tone	1.61747730
32	MP0005646_abnormal_pituitary_gland	1.59787378
33	MP0001929_abnormal_gametogenesis	1.56504358
34	MP0005174_abnormal_tail_pigmentation	1.56056322
35	MP0002938_white_spotting	1.47949715
36	MP0002876_abnormal_thyroid_physiology	1.45442191
37	MP0003890_abnormal_embryonic-extraembry	1.43629592
38	MP0003136_yellow_coat_color	1.43501951
39	MP0002210_abnormal_sex_determination	1.38833326
40	MP0003698_abnormal_male_reproductive	1.38562297
41	MP0009697_abnormal_copulation	1.37645860
42	MP0004043_abnormal_pH_regulation	1.36650654
43	MP0001986_abnormal_taste_sensitivity	1.35491361
44	MP0002638_abnormal_pupillary_reflex	1.33122943
45	MP0003786_premature_aging	1.29358955
46	MP0008961_abnormal_basal_metabolism	1.28138499
47	MP0003183_abnormal_peptide_metabolism	1.27392618
48	MP0000631_abnormal_neuroendocrine_gland	1.24851128
49	MP0006036_abnormal_mitochondrial_physio	1.23459332
50	MP0003806_abnormal_nucleotide_metabolis	1.23389852
51	MP0000653_abnormal_sex_gland	1.21341174
52	MP0005379_endocrine/exocrine_gland_phen	1.19632051
53	MP0005075_abnormal_melanosome_morpholog	1.17898938
54	MP0001485_abnormal_pinna_reflex	1.16739755
55	MP0009745_abnormal_behavioral_response	1.15982133
56	MP0001145_abnormal_male_reproductive	1.15542267
57	MP0006276_abnormal_autonomic_nervous	1.15107444
58	MP0005084_abnormal_gallbladder_morpholo	1.12837437
59	MP0003011_delayed_dark_adaptation	1.11592032
60	MP0000383_abnormal_hair_follicle	1.10475741
61	MP0006035_abnormal_mitochondrial_morpho	1.09934874
62	MP0001919_abnormal_reproductive_system	1.09506147
63	MP0001984_abnormal_olfaction	1.08607591
64	MP0002095_abnormal_skin_pigmentation	1.07912879
65	MP0004215_abnormal_myocardial_fiber	1.06564666
66	MP0002653_abnormal_ependyma_morphology	1.04689942
67	MP0002272_abnormal_nervous_system	1.00835979
68	MP0001119_abnormal_female_reproductive	0.97123147
69	MP0001764_abnormal_homeostasis	0.96716669
70	MP0001501_abnormal_sleep_pattern	0.95780067
71	MP0005670_abnormal_white_adipose	0.95072522
72	MP0002277_abnormal_respiratory_mucosa	0.91323419
73	MP0005395_other_phenotype	0.89709070
74	MP0003077_abnormal_cell_cycle	0.89463414
75	MP0002928_abnormal_bile_duct	0.88807050
76	MP0010386_abnormal_urinary_bladder	0.85492022
77	MP0002138_abnormal_hepatobiliary_system	0.85144848
78	MP0008775_abnormal_heart_ventricle	0.84890797
79	MP0004133_heterotaxia	0.84041811
80	MP0004145_abnormal_muscle_electrophysio	0.83921313
81	MP0002735_abnormal_chemical_nociception	0.83813356
82	MP0000230_abnormal_systemic_arterial	0.82864816
83	MP0003121_genomic_imprinting	0.82307461
84	MP0005266_abnormal_metabolism	0.81866533
85	MP0002693_abnormal_pancreas_physiology	0.81518406
86	MP0005332_abnormal_amino_acid	0.80601270
87	MP0003252_abnormal_bile_duct	0.78633067
88	MP0001293_anophthalmia	0.75948933
89	MP0008789_abnormal_olfactory_epithelium	0.75509483
90	MP0005647_abnormal_sex_gland	0.74849410
91	MP0005195_abnormal_posterior_eye	0.74077097
92	MP0003186_abnormal_redox_activity	0.73849576
93	MP0008007_abnormal_cellular_replicative	0.72096987
94	MP0000015_abnormal_ear_pigmentation	0.72005536
95	MP0004885_abnormal_endolymph	0.71507936
96	MP0000647_abnormal_sebaceous_gland	0.71086195
97	MP0001486_abnormal_startle_reflex	0.70935069
98	MP0002067_abnormal_sensory_capabilities	0.70770426
99	MP0004957_abnormal_blastocyst_morpholog	0.70744456
100	MP0002234_abnormal_pharynx_morphology	0.67276953

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.11701822
2	Pancreatic fibrosis (HP:0100732)	3.77809366
3	Abnormality of midbrain morphology (HP:0002418)	3.64566607
4	Molar tooth sign on MRI (HP:0002419)	3.64566607
5	True hermaphroditism (HP:0010459)	3.57239123
6	Congenital stationary night blindness (HP:0007642)	3.37736814
7	Nephronophthisis (HP:0000090)	3.21980536
8	Abnormality of the renal cortex (HP:0011035)	3.21356771
9	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.17050911
10	Abnormality of alanine metabolism (HP:0010916)	3.17050911
11	Hyperalaninemia (HP:0003348)	3.17050911
12	Attenuation of retinal blood vessels (HP:0007843)	2.97950485
13	Abnormality of the renal medulla (HP:0100957)	2.86558890
14	Chronic hepatic failure (HP:0100626)	2.70982436
15	Type II lissencephaly (HP:0007260)	2.65384399
16	Acute necrotizing encephalopathy (HP:0006965)	2.59296355
17	Medial flaring of the eyebrow (HP:0010747)	2.56482941
18	Abolished electroretinogram (ERG) (HP:0000550)	2.55855243
19	Increased CSF lactate (HP:0002490)	2.51506092
20	Renal cortical cysts (HP:0000803)	2.50549581
21	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.47651966
22	Acute encephalopathy (HP:0006846)	2.47600586
23	Tubular atrophy (HP:0000092)	2.47559794
24	Gaze-evoked nystagmus (HP:0000640)	2.44274394
25	Mitochondrial inheritance (HP:0001427)	2.39850442
26	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.38689064
27	Abnormality of the pons (HP:0007361)	2.37103564
28	Cystic liver disease (HP:0006706)	2.37068869
29	Birth length less than 3rd percentile (HP:0003561)	2.34088889
30	Large for gestational age (HP:0001520)	2.29988358
31	Hypoplasia of the pons (HP:0012110)	2.29925785
32	Progressive macrocephaly (HP:0004481)	2.28926490
33	Abnormal mitochondria in muscle tissue (HP:0008316)	2.27176636
34	Congenital, generalized hypertrichosis (HP:0004540)	2.27055843
35	3-Methylglutaconic aciduria (HP:0003535)	2.25635546
36	Male pseudohermaphroditism (HP:0000037)	2.24276926
37	Pendular nystagmus (HP:0012043)	2.23265653
38	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.17874277
39	Decreased central vision (HP:0007663)	2.17694192
40	Volvulus (HP:0002580)	2.16414028
41	Sclerocornea (HP:0000647)	2.16143838
42	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.15298641
43	Furrowed tongue (HP:0000221)	2.12315481
44	Oligodactyly (hands) (HP:0001180)	2.12055506
45	Abnormality of the ileum (HP:0001549)	2.11534340
46	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10831671
47	Absent/shortened dynein arms (HP:0200106)	2.07782249
48	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.07782249
49	Inability to walk (HP:0002540)	2.07568655
50	Progressive inability to walk (HP:0002505)	2.07431102
51	Hepatic necrosis (HP:0002605)	2.06302052
52	Hyperventilation (HP:0002883)	2.06116186
53	Abnormal biliary tract physiology (HP:0012439)	2.05372123
54	Bile duct proliferation (HP:0001408)	2.05372123
55	Meckel diverticulum (HP:0002245)	2.05198729
56	Genetic anticipation (HP:0003743)	2.04879958
57	Absent thumb (HP:0009777)	2.04412085
58	Abnormal rod and cone electroretinograms (HP:0008323)	2.04388521
59	Cerebellar dysplasia (HP:0007033)	2.03728021
60	Polydipsia (HP:0001959)	2.03616819
61	Abnormal drinking behavior (HP:0030082)	2.03616819
62	Chromsome breakage (HP:0040012)	2.03439241
63	Methylmalonic acidemia (HP:0002912)	2.00024922
64	Concave nail (HP:0001598)	1.98478186
65	Clubbing of toes (HP:0100760)	1.97061387
66	Hepatocellular necrosis (HP:0001404)	1.96659322
67	Abnormality of the renal collecting system (HP:0004742)	1.96512562
68	Clumsiness (HP:0002312)	1.96414793
69	Anencephaly (HP:0002323)	1.94753649
70	Abnormality of chromosome stability (HP:0003220)	1.94213131
71	Increased serum lactate (HP:0002151)	1.93823867
72	Sloping forehead (HP:0000340)	1.91885369
73	Constricted visual fields (HP:0001133)	1.90694086
74	Abnormality of macular pigmentation (HP:0008002)	1.90632056
75	Patellar aplasia (HP:0006443)	1.89621600
76	Duplicated collecting system (HP:0000081)	1.88733065
77	Congenital hepatic fibrosis (HP:0002612)	1.87282191
78	Colon cancer (HP:0003003)	1.86521802
79	Lipid accumulation in hepatocytes (HP:0006561)	1.83568825
80	Bony spicule pigmentary retinopathy (HP:0007737)	1.83143299
81	Methylmalonic aciduria (HP:0012120)	1.81957931
82	Optic disc pallor (HP:0000543)	1.81139228
83	Abnormality of the preputium (HP:0100587)	1.81088020
84	Aplasia/Hypoplasia of the patella (HP:0006498)	1.81040670
85	Stomach cancer (HP:0012126)	1.80883475
86	Hypothermia (HP:0002045)	1.77425694
87	Febrile seizures (HP:0002373)	1.77301807
88	Congenital primary aphakia (HP:0007707)	1.76724496
89	Abnormality of the labia minora (HP:0012880)	1.76473842
90	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.75964559
91	Ectopic kidney (HP:0000086)	1.75644785
92	Abnormal number of erythroid precursors (HP:0012131)	1.75555895
93	Progressive cerebellar ataxia (HP:0002073)	1.74942501
94	Protruding tongue (HP:0010808)	1.74851323
95	Abnormal protein glycosylation (HP:0012346)	1.74629063
96	Abnormal glycosylation (HP:0012345)	1.74629063
97	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.74629063
98	Abnormal protein N-linked glycosylation (HP:0012347)	1.74629063
99	Lissencephaly (HP:0001339)	1.73926796
100	Chorioretinal atrophy (HP:0000533)	1.72307189

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.00545555
2	ZAK	3.34479600
3	BMPR1B	3.09502240
4	ACVR1B	2.75777550
5	MAP4K2	2.68999409
6	NUAK1	2.56162783
7	TLK1	2.50923113
8	ADRBK2	2.45517671
9	MST4	2.31124009
10	GRK1	2.18104630
11	WNK4	1.97941986
12	INSRR	1.89600756
13	TAOK3	1.88571613
14	WNK3	1.85291963
15	BRSK2	1.71546129
16	PINK1	1.67243031
17	OXSR1	1.60327748
18	STK39	1.58598822
19	BUB1	1.54179825
20	MKNK2	1.50269624
21	PIK3CG	1.48374375
22	TEC	1.43177186
23	PLK4	1.41947231
24	VRK1	1.39745669
25	TXK	1.31018893
26	EIF2AK3	1.27717610
27	PNCK	1.26078582
28	TRIM28	1.23968959
29	TNIK	1.23605486
30	WEE1	1.23390518
31	CDC7	1.15143728
32	MAPK13	1.10342453
33	PLK3	1.08645200
34	STK3	1.00735456
35	ADRBK1	1.00307548
36	MAP3K4	0.99445089
37	PBK	0.95002146
38	MKNK1	0.92777391
39	STK38L	0.88947190
40	PTK2B	0.88654824
41	NME1	0.88359701
42	VRK2	0.85724686
43	IKBKB	0.84523723
44	MAP2K6	0.83175684
45	RPS6KA5	0.82635653
46	PLK1	0.81729468
47	PLK2	0.81028862
48	TGFBR1	0.78740085
49	SRPK1	0.76892250
50	ATR	0.73277530
51	NEK2	0.72425413
52	MUSK	0.70358370
53	STK16	0.70024498
54	CAMKK2	0.69513684
55	MAPKAPK3	0.68301697
56	CHEK2	0.67588726
57	PRKCE	0.66107653
58	CASK	0.63829259
59	PRKCG	0.62814925
60	AKT3	0.61470677
61	DAPK2	0.60966855
62	CSNK1G1	0.60732114
63	PIK3CA	0.58517949
64	EIF2AK1	0.57972138
65	PAK3	0.57928254
66	CSNK1A1L	0.57876982
67	TTK	0.57545817
68	BMPR2	0.56991994
69	ITK	0.54796528
70	DYRK2	0.53285544
71	PASK	0.52972699
72	ATM	0.52907780
73	MARK3	0.52739032
74	PRKCQ	0.50762893
75	CSNK1G3	0.49275529
76	CDK8	0.48035767
77	PRKCI	0.46893740
78	STK4	0.46130378
79	CDK3	0.45922539
80	OBSCN	0.44894686
81	CSNK1G2	0.44853680
82	IRAK1	0.44555949
83	BCKDK	0.43955640
84	MAP2K7	0.42228950
85	EIF2AK2	0.42141753
86	NLK	0.39510898
87	TSSK6	0.39253040
88	MAPKAPK5	0.38858953
89	AURKB	0.38080929
90	BTK	0.37515091
91	CHUK	0.36338798
92	SYK	0.35492336
93	KIT	0.35236289
94	NEK1	0.33687603
95	WNK1	0.33506299
96	CSNK1D	0.33164258
97	PIM1	0.33073361
98	PHKG2	0.31929951
99	PHKG1	0.31929951
100	CDK19	0.31305610

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	2.86924220
2	RNA polymerase_Homo sapiens_hsa03020	2.68987992
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.60791416
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.49091427
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.30305031
6	Phototransduction_Homo sapiens_hsa04744	2.28897682
7	Proteasome_Homo sapiens_hsa03050	2.27960675
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.15557675
9	Basal transcription factors_Homo sapiens_hsa03022	2.15336953
10	Parkinsons disease_Homo sapiens_hsa05012	2.10982594
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.10874782
12	One carbon pool by folate_Homo sapiens_hsa00670	2.10528650
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.04958685
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.04126004
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.99054349
16	Butanoate metabolism_Homo sapiens_hsa00650	1.98605294
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.94181448
18	Protein export_Homo sapiens_hsa03060	1.89297899
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.81558137
20	Mismatch repair_Homo sapiens_hsa03430	1.78747781
21	Ribosome_Homo sapiens_hsa03010	1.75895080
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.74724961
23	RNA degradation_Homo sapiens_hsa03018	1.73600214
24	Huntingtons disease_Homo sapiens_hsa05016	1.59239761
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.55491724
26	Caffeine metabolism_Homo sapiens_hsa00232	1.52313027
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.49532029
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.49015074
29	Non-homologous end-joining_Homo sapiens_hsa03450	1.42101141
30	Propanoate metabolism_Homo sapiens_hsa00640	1.41431867
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.39660845
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.38427594
33	Nucleotide excision repair_Homo sapiens_hsa03420	1.34744494
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.31175547
35	Alzheimers disease_Homo sapiens_hsa05010	1.24549011
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.21230065
37	Olfactory transduction_Homo sapiens_hsa04740	1.19436243
38	Purine metabolism_Homo sapiens_hsa00230	1.16604030
39	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.15466496
40	DNA replication_Homo sapiens_hsa03030	1.12702963
41	Ether lipid metabolism_Homo sapiens_hsa00565	1.12490961
42	Peroxisome_Homo sapiens_hsa04146	1.09346255
43	RNA transport_Homo sapiens_hsa03013	1.09275252
44	Base excision repair_Homo sapiens_hsa03410	1.05793954
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.03677733
46	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.02663961
47	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.00510478
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.98587582
49	Taste transduction_Homo sapiens_hsa04742	0.98342656
50	Regulation of autophagy_Homo sapiens_hsa04140	0.97558916
51	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.96349911
52	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.96135092
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.93415153
54	Nicotine addiction_Homo sapiens_hsa05033	0.93084006
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92356272
56	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.92087180
57	Sulfur relay system_Homo sapiens_hsa04122	0.89048371
58	ABC transporters_Homo sapiens_hsa02010	0.88690822
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.84037276
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.83720313
61	Cardiac muscle contraction_Homo sapiens_hsa04260	0.80155485
62	Retinol metabolism_Homo sapiens_hsa00830	0.78073322
63	Primary immunodeficiency_Homo sapiens_hsa05340	0.77833430
64	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.74270485
65	Metabolic pathways_Homo sapiens_hsa01100	0.69705568
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69595915
67	Graft-versus-host disease_Homo sapiens_hsa05332	0.68448421
68	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.67468485
69	Asthma_Homo sapiens_hsa05310	0.66867347
70	beta-Alanine metabolism_Homo sapiens_hsa00410	0.65030692
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.62592778
72	Spliceosome_Homo sapiens_hsa03040	0.61596259
73	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.60585799
74	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.58871012
75	Sulfur metabolism_Homo sapiens_hsa00920	0.58609580
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.57114704
77	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.56049976
78	Cell cycle_Homo sapiens_hsa04110	0.55873453
79	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.54848219
80	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53733620
81	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53186619
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.52805009
83	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51865706
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.51644319
85	Glutathione metabolism_Homo sapiens_hsa00480	0.51614766
86	p53 signaling pathway_Homo sapiens_hsa04115	0.50716931
87	Serotonergic synapse_Homo sapiens_hsa04726	0.49910488
88	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46790971
89	Fatty acid elongation_Homo sapiens_hsa00062	0.46507012
90	Circadian rhythm_Homo sapiens_hsa04710	0.44658613
91	Fatty acid degradation_Homo sapiens_hsa00071	0.44504256
92	Type I diabetes mellitus_Homo sapiens_hsa04940	0.44034464
93	Morphine addiction_Homo sapiens_hsa05032	0.43597776
94	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.41914920
95	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.41486127
96	Fatty acid metabolism_Homo sapiens_hsa01212	0.40250459
97	Oocyte meiosis_Homo sapiens_hsa04114	0.33983815
98	Folate biosynthesis_Homo sapiens_hsa00790	0.32197785
99	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.32193653
100	Calcium signaling pathway_Homo sapiens_hsa04020	0.31760069

DLEU1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »