DLG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)4.72078323
2desmosome organization (GO:0002934)4.59843088
3synaptic vesicle docking involved in exocytosis (GO:0016081)4.52220509
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.33585575
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.29987235
6glutamate secretion (GO:0014047)4.28841890
7synaptic vesicle maturation (GO:0016188)4.20445809
8locomotory exploration behavior (GO:0035641)4.07336092
9axon ensheathment in central nervous system (GO:0032291)3.97914139
10central nervous system myelination (GO:0022010)3.97914139
11nuclear pore complex assembly (GO:0051292)3.92541280
12cell adhesion mediated by integrin (GO:0033627)3.87129997
13cerebellar granule cell differentiation (GO:0021707)3.74431507
14regulation of transforming growth factor beta2 production (GO:0032909)3.73244504
15presynaptic membrane organization (GO:0097090)3.71500143
16presynaptic membrane assembly (GO:0097105)3.67981212
17myelination (GO:0042552)3.62274124
18ensheathment of neurons (GO:0007272)3.61403416
19axon ensheathment (GO:0008366)3.61403416
20bundle of His cell to Purkinje myocyte communication (GO:0086069)3.51890873
21nuclear pore organization (GO:0006999)3.51256320
22L-amino acid import (GO:0043092)3.47038938
23negative regulation of neurotransmitter secretion (GO:0046929)3.45255493
24synaptic vesicle exocytosis (GO:0016079)3.42937321
25regulation of synaptic vesicle exocytosis (GO:2000300)3.41320008
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.36075595
27apical protein localization (GO:0045176)3.34361345
28cytoskeletal anchoring at plasma membrane (GO:0007016)3.33111677
29neuronal action potential propagation (GO:0019227)3.32754107
30neuromuscular process controlling balance (GO:0050885)3.32648283
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.28182678
32regulation of dendritic spine morphogenesis (GO:0061001)3.26333699
33negative regulation of keratinocyte proliferation (GO:0010839)3.19703500
34negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.17380292
35cell-substrate junction assembly (GO:0007044)3.15931575
36regulation of long-term neuronal synaptic plasticity (GO:0048169)3.12831736
37neurotransmitter secretion (GO:0007269)3.11717257
38neuromuscular junction development (GO:0007528)3.06484282
39neuron-neuron synaptic transmission (GO:0007270)3.04894860
40asymmetric protein localization (GO:0008105)3.02461967
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.02120620
42neuronal ion channel clustering (GO:0045161)3.01887691
43synaptic transmission, glutamatergic (GO:0035249)3.01403323
44notochord development (GO:0030903)3.01107986
45vocalization behavior (GO:0071625)3.00751363
46regulation of voltage-gated calcium channel activity (GO:1901385)2.99299982
47mitotic sister chromatid cohesion (GO:0007064)2.97072095
48regulation of neuronal synaptic plasticity (GO:0048168)2.95703092
49hippo signaling (GO:0035329)2.91483611
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.90316014
51transmission of nerve impulse (GO:0019226)2.90029944
52regulation of hippo signaling (GO:0035330)2.88913131
53paraxial mesoderm development (GO:0048339)2.88684411
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.88029129
55ionotropic glutamate receptor signaling pathway (GO:0035235)2.87473789
56gap junction assembly (GO:0016264)2.86840797
57regulation of synaptic vesicle transport (GO:1902803)2.86624835
58regulation of postsynaptic membrane potential (GO:0060078)2.86108283
59behavioral response to cocaine (GO:0048148)2.85676639
60negative regulation of neurotransmitter transport (GO:0051589)2.83886551
61regulation of glutamate receptor signaling pathway (GO:1900449)2.83835395
62positive regulation of synapse maturation (GO:0090129)2.83143512
63long-term memory (GO:0007616)2.82896766
64long-term synaptic potentiation (GO:0060291)2.81485620
65regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.81115864
66positive regulation of membrane potential (GO:0045838)2.80296190
67neurotransmitter-gated ion channel clustering (GO:0072578)2.73692908
68regulation of dendritic spine development (GO:0060998)2.71782531
69positive regulation of fibroblast migration (GO:0010763)2.71504421
70auditory behavior (GO:0031223)2.71329867
71neuromuscular process (GO:0050905)2.69956544
72embryonic retina morphogenesis in camera-type eye (GO:0060059)2.69450858
73COPII vesicle coating (GO:0048208)2.68933896
74regulation of synaptic plasticity (GO:0048167)2.68478706
75protein localization to endosome (GO:0036010)2.68350687
76establishment of nucleus localization (GO:0040023)2.67588633
77amino acid import (GO:0043090)2.67201296
78vesicle transport along microtubule (GO:0047496)2.64541099
79dendritic spine morphogenesis (GO:0060997)2.64374251
80negative regulation of chondrocyte differentiation (GO:0032331)2.64074906
81pore complex assembly (GO:0046931)2.63316237
82plasma membrane repair (GO:0001778)2.62609555
83mesodermal cell differentiation (GO:0048333)2.61961254
84myelination in peripheral nervous system (GO:0022011)2.61264507
85peripheral nervous system axon ensheathment (GO:0032292)2.61264507
86negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.61249324
87adult walking behavior (GO:0007628)2.61030640
88protein localization to synapse (GO:0035418)2.60539160
89chondrocyte proliferation (GO:0035988)2.58696714
90cytoplasmic mRNA processing body assembly (GO:0033962)2.58374374
91gamma-aminobutyric acid signaling pathway (GO:0007214)2.58213435
92labyrinthine layer development (GO:0060711)2.57913518
93neurotransmitter catabolic process (GO:0042135)2.54940575
94membrane hyperpolarization (GO:0060081)2.54223588
95regulation of neurotransmitter secretion (GO:0046928)2.54175886
96dendrite morphogenesis (GO:0048813)2.52915701
97regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.52540894
98dorsal/ventral axis specification (GO:0009950)2.51544643
99glutamate receptor signaling pathway (GO:0007215)2.50875701
100gamma-aminobutyric acid transport (GO:0015812)2.50742830
101retina vasculature morphogenesis in camera-type eye (GO:0061299)2.49448777
102activation of protein kinase A activity (GO:0034199)2.45335226
103lipid translocation (GO:0034204)2.44379002
104phospholipid translocation (GO:0045332)2.44379002
105cytoskeleton-dependent cytokinesis (GO:0061640)2.43813567
106* cell-cell junction assembly (GO:0007043)2.42401824
107cerebellar Purkinje cell differentiation (GO:0021702)2.42395163
108regulation of centriole replication (GO:0046599)2.42263444
109mating behavior (GO:0007617)2.42048225
110regulation of synapse structural plasticity (GO:0051823)2.40848656
111cell-substrate adherens junction assembly (GO:0007045)2.40145777
112focal adhesion assembly (GO:0048041)2.40145777
113ephrin receptor signaling pathway (GO:0048013)2.39687358
114neurotransmitter transport (GO:0006836)2.39675079
115embryonic foregut morphogenesis (GO:0048617)2.39405766
116regulation of synaptic transmission, glutamatergic (GO:0051966)2.38711868
117mechanosensory behavior (GO:0007638)2.38660453
118negative regulation of dendrite morphogenesis (GO:0050774)2.38375579
119vesicle docking involved in exocytosis (GO:0006904)2.38187446
120regulation of translational termination (GO:0006449)2.37714266
121regulation of clathrin-mediated endocytosis (GO:2000369)2.37468544
122glycerophospholipid catabolic process (GO:0046475)2.37322973
123mitotic cytokinesis (GO:0000281)2.36868069
124layer formation in cerebral cortex (GO:0021819)2.36666942
125Golgi to endosome transport (GO:0006895)2.36292264
126UDP-N-acetylglucosamine metabolic process (GO:0006047)2.35781330
127synapse organization (GO:0050808)2.35710500
128endodermal cell differentiation (GO:0035987)2.35082131
129regulation of neurotransmitter transport (GO:0051588)2.34817729
130negative regulation of hormone biosynthetic process (GO:0032353)2.34262705
131negative regulation of hormone metabolic process (GO:0032351)2.34262705
132morphogenesis of an epithelial sheet (GO:0002011)2.34191114
133neuron cell-cell adhesion (GO:0007158)2.32888155
134peptidyl-tyrosine autophosphorylation (GO:0038083)2.32774531
135dendritic spine organization (GO:0097061)2.32200579
136regulation of keratinocyte proliferation (GO:0010837)2.32182336
137spindle assembly involved in mitosis (GO:0090307)2.31641040
138astrocyte development (GO:0014002)2.31581139
139anterior/posterior axis specification, embryo (GO:0008595)2.31494481
140cellular potassium ion homeostasis (GO:0030007)2.31279758
141pericardium development (GO:0060039)2.31011537
142regulation of Rac protein signal transduction (GO:0035020)2.30448847
143regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.30249322
144regulation of cardioblast differentiation (GO:0051890)2.30072149
145adherens junction assembly (GO:0034333)2.28568410
146regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.28251280
147genitalia morphogenesis (GO:0035112)2.27665497
148regulation of mitotic spindle organization (GO:0060236)2.23488027
149* cell junction assembly (GO:0034329)2.23431661
150NLS-bearing protein import into nucleus (GO:0006607)2.19905007
151regulation of RNA export from nucleus (GO:0046831)2.19650331
152positive regulation of protein autophosphorylation (GO:0031954)2.19309120
153lymphangiogenesis (GO:0001946)2.18922077
154regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.17906667
155activation of Rac GTPase activity (GO:0032863)2.15905050
156artery development (GO:0060840)2.12964657
157cellular response to vitamin D (GO:0071305)2.12566981
158positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.11813613
159positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.11813613
160positive regulation of mitotic sister chromatid separation (GO:1901970)2.11813613
161regulation of DNA endoreduplication (GO:0032875)2.11491308
162regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.11067850
163negative regulation of DNA repair (GO:0045738)2.10575909
164* tight junction assembly (GO:0070830)2.10466732
165myoblast fusion (GO:0007520)2.10253672
166positive regulation of cytokinesis (GO:0032467)2.09941550
167regulation of nucleobase-containing compound transport (GO:0032239)2.09717598
168cell communication involved in cardiac conduction (GO:0086065)2.08904365
169cellular response to vitamin (GO:0071295)2.06936034
170iron ion import (GO:0097286)2.06590454
171establishment of spindle localization (GO:0051293)2.06361554
172protein localization to cell surface (GO:0034394)2.05161794
173chondrocyte development (GO:0002063)2.04529840
174insulin-like growth factor receptor signaling pathway (GO:0048009)2.03327192
175mitotic chromosome condensation (GO:0007076)2.03319728
176membrane protein ectodomain proteolysis (GO:0006509)2.03220027
177keratinocyte proliferation (GO:0043616)2.02860800
178substrate adhesion-dependent cell spreading (GO:0034446)2.02674538
179epithelial cell-cell adhesion (GO:0090136)2.01803943
180centrosome duplication (GO:0051298)2.01724389
181import into cell (GO:0098657)2.01183806
182* cell junction organization (GO:0034330)2.00548428
183skin morphogenesis (GO:0043589)2.00042199
184ectoderm development (GO:0007398)1.98381114
185vesicle coating (GO:0006901)1.98007344
186membrane assembly (GO:0071709)1.96606825
187glomerular visceral epithelial cell development (GO:0072015)1.96488360
188polarized epithelial cell differentiation (GO:0030859)1.94274012

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.15604169
2GBX2_23144817_ChIP-Seq_PC3_Human3.13114757
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.79727526
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.60175075
5DROSHA_22980978_ChIP-Seq_HELA_Human2.38276014
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.38074915
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.36386830
8EZH2_22144423_ChIP-Seq_EOC_Human2.31444451
9TP53_16413492_ChIP-PET_HCT116_Human2.21344631
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.18134723
11AR_21909140_ChIP-Seq_LNCAP_Human2.12290648
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.10930804
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.10870483
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.01809252
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.95361346
16FOXM1_23109430_ChIP-Seq_U2OS_Human1.93039420
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92188711
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91271034
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91271034
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89832034
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89053151
22SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.88086758
23FOXM1_26456572_ChIP-Seq_MCF-7_Human1.80466083
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77728084
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75989671
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74009701
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.71970878
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.69954857
29* BRD4_25478319_ChIP-Seq_HGPS_Human1.69262296
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66751053
31* CJUN_26792858_Chip-Seq_BT549_Human1.66069812
32SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.64946072
33SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.64946072
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62249297
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.61622845
36TP53_18474530_ChIP-ChIP_U2OS_Human1.60744333
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60483932
38AR_21572438_ChIP-Seq_LNCaP_Human1.59248287
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59098224
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57710945
41* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55547809
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51703807
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50873935
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50795002
45E2F7_22180533_ChIP-Seq_HELA_Human1.47682681
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47248347
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.43192898
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43134038
49* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42535598
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42117454
51CTNNB1_20460455_ChIP-Seq_HCT116_Human1.41755233
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.41397439
53* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40947143
54AHR_22903824_ChIP-Seq_MCF-7_Human1.40599316
55FUS_26573619_Chip-Seq_HEK293_Human1.38629326
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38411525
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37574417
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37343374
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.37062491
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.36932627
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.36653127
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.36318119
63TAF15_26573619_Chip-Seq_HEK293_Human1.36274478
64STAT3_23295773_ChIP-Seq_U87_Human1.35923578
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34784593
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34607530
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.33597823
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.33236530
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.32940160
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32723360
71TCF4_18268006_ChIP-ChIP_LS174T_Human1.32243585
72REST_21632747_ChIP-Seq_MESCs_Mouse1.32007762
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.31171137
74EED_16625203_ChIP-ChIP_MESCs_Mouse1.31042755
75* SOX2_21211035_ChIP-Seq_LN229_Gbm1.29539740
76* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26490125
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26458001
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.26306257
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26234383
80FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.26151617
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25386662
82CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25385340
83* SMAD3_21741376_ChIP-Seq_EPCs_Human1.25020650
84EP300_21415370_ChIP-Seq_HL-1_Mouse1.24520111
85WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23520245
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.22365299
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22050474
88SMAD4_21799915_ChIP-Seq_A2780_Human1.21803986
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21437077
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21040299
91NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20572039
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20572039
93* TP63_23658742_ChIP-Seq_EP156T_Human1.20536194
94AR_19668381_ChIP-Seq_PC3_Human1.20462884
95ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20389222
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20331434
97* TCF4_23295773_ChIP-Seq_U87_Human1.19925750
98ESR2_21235772_ChIP-Seq_MCF-7_Human1.19527609
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19301089
100REST_18959480_ChIP-ChIP_MESCs_Mouse1.17769225
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15393141
102STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12830758
103ERG_21242973_ChIP-ChIP_JURKAT_Human1.12764876
104NANOG_18555785_Chip-Seq_ESCs_Mouse1.12627531
105SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12061237
106* ER_23166858_ChIP-Seq_MCF-7_Human1.11780066
107* FOXA2_19822575_ChIP-Seq_HepG2_Human1.09919365
108PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09739159
109ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09296749
110SMAD3_21741376_ChIP-Seq_HESCs_Human1.09257407
111TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08966284
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08697039
113P300_19829295_ChIP-Seq_ESCs_Human1.08550146
114TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08479767
115* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07835283
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06704476
117NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06607504
118FOXO3_23340844_ChIP-Seq_DLD1_Human1.06564018
119PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05916469
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04926346
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03162482
122* SOX9_26525672_Chip-Seq_HEART_Mouse1.03002930
123HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02166732
124FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00923438
125CDX2_22108803_ChIP-Seq_LS180_Human1.00828712
126CDX2_20551321_ChIP-Seq_CACO-2_Human1.00582976
127GATA2_21666600_ChIP-Seq_HMVEC_Human1.00448715
128* GATA1_26923725_Chip-Seq_HPCs_Mouse1.00336355
129ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00047886
130E2F1_18555785_Chip-Seq_ESCs_Mouse0.99800650
131* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99776019
132* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99678021
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97714630
134SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97370981
135TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97297070
136ISL1_27105846_Chip-Seq_CPCs_Mouse0.96700529
137EOMES_21245162_ChIP-Seq_HESCs_Human0.94670188
138EWS_26573619_Chip-Seq_HEK293_Human0.94649614
139* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93968369
140NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93725618
141ESR1_21235772_ChIP-Seq_MCF-7_Human0.93455446
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.92389679
143TET1_21490601_ChIP-Seq_MESCs_Mouse0.92228147
144TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91625878
145POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.90778636
146RING1B_27294783_Chip-Seq_NPCs_Mouse0.90692558
147WT1_19549856_ChIP-ChIP_CCG9911_Human0.90542320

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.80585056
2MP0004270_analgesia3.08404787
3MP0003880_abnormal_central_pattern2.85837070
4MP0003635_abnormal_synaptic_transmissio2.83222285
5MP0005623_abnormal_meninges_morphology2.68280867
6MP0002822_catalepsy2.63637628
7MP0003566_abnormal_cell_adhesion2.62968491
8MP0009046_muscle_twitch2.52824788
9MP0008057_abnormal_DNA_replication2.41544029
10MP0003941_abnormal_skin_development2.40749918
11MP0009745_abnormal_behavioral_response2.39530948
12MP0002064_seizures2.37979326
13MP0004885_abnormal_endolymph2.27740519
14MP0000920_abnormal_myelination2.16291778
15MP0002063_abnormal_learning/memory/cond2.10764632
16MP0008438_abnormal_cutaneous_collagen2.06035225
17MP0002272_abnormal_nervous_system2.05864446
18MP0009780_abnormal_chondrocyte_physiolo2.02832603
19MP0001486_abnormal_startle_reflex1.97375418
20MP0005409_darkened_coat_color1.84367807
21MP0010234_abnormal_vibrissa_follicle1.76714695
22MP0003329_amyloid_beta_deposits1.74722476
23MP0003950_abnormal_plasma_membrane1.72400823
24MP0002877_abnormal_melanocyte_morpholog1.68847414
25MP0002572_abnormal_emotion/affect_behav1.67600457
26MP0000427_abnormal_hair_cycle1.65440449
27MP0001177_atelectasis1.64943054
28MP0001299_abnormal_eye_distance/1.62393012
29MP0003632_abnormal_nervous_system1.61965883
30MP0010368_abnormal_lymphatic_system1.58701764
31MP0000537_abnormal_urethra_morphology1.57287167
32MP0010030_abnormal_orbit_morphology1.56016206
33MP0003690_abnormal_glial_cell1.53504612
34MP0005171_absent_coat_pigmentation1.50706055
35MP0010678_abnormal_skin_adnexa1.50297075
36MP0001485_abnormal_pinna_reflex1.50249018
37MP0002796_impaired_skin_barrier1.44015441
38* MP0000428_abnormal_craniofacial_morphol1.40876180
39MP0000569_abnormal_digit_pigmentation1.40576610
40MP0002060_abnormal_skin_morphology1.36725928
41MP0002734_abnormal_mechanical_nocicepti1.36578403
42MP0004272_abnormal_basement_membrane1.33408469
43MP0005386_behavior/neurological_phenoty1.31708690
44MP0004924_abnormal_behavior1.31708690
45MP0003787_abnormal_imprinting1.31250738
46MP0008569_lethality_at_weaning1.30860808
47MP0004264_abnormal_extraembryonic_tissu1.28639117
48MP0009053_abnormal_anal_canal1.28557875
49MP0000955_abnormal_spinal_cord1.27600878
50MP0001440_abnormal_grooming_behavior1.27117527
51MP0003705_abnormal_hypodermis_morpholog1.26247095
52MP0005023_abnormal_wound_healing1.26236274
53MP0005275_abnormal_skin_tensile1.23062326
54MP0003868_abnormal_feces_composition1.22936538
55MP0003283_abnormal_digestive_organ1.21368948
56MP0000013_abnormal_adipose_tissue1.20476718
57MP0003937_abnormal_limbs/digits/tail_de1.18728145
58MP0010352_gastrointestinal_tract_polyps1.17879227
59MP0004134_abnormal_chest_morphology1.17659219
60MP0004145_abnormal_muscle_electrophysio1.15889182
61MP0002009_preneoplasia1.15145876
62MP0008877_abnormal_DNA_methylation1.13602469
63MP0001348_abnormal_lacrimal_gland1.12876871
64MP0003631_nervous_system_phenotype1.12336986
65MP0005248_abnormal_Harderian_gland1.11815125
66MP0000778_abnormal_nervous_system1.11704302
67MP0000747_muscle_weakness1.11628899
68MP0001879_abnormal_lymphatic_vessel1.10730256
69MP0002084_abnormal_developmental_patter1.10680550
70MP0005503_abnormal_tendon_morphology1.09895221
71MP0003879_abnormal_hair_cell1.07871580
72MP0002896_abnormal_bone_mineralization1.07851969
73MP0002269_muscular_atrophy1.07714702
74MP0002066_abnormal_motor_capabilities/c1.06946420
75MP0001346_abnormal_lacrimal_gland1.06581682
76MP0005257_abnormal_intraocular_pressure1.06208627
77MP0002697_abnormal_eye_size1.05089972
78* MP0003935_abnormal_craniofacial_develop1.04450669
79MP0004084_abnormal_cardiac_muscle1.03953923
80MP0005501_abnormal_skin_physiology1.02875203
81* MP0002882_abnormal_neuron_morphology1.02824050
82MP0004043_abnormal_pH_regulation1.02800120
83MP0005423_abnormal_somatic_nervous1.02643331
84MP0000377_abnormal_hair_follicle1.02071391
85MP0003890_abnormal_embryonic-extraembry1.02046373
86* MP0000432_abnormal_head_morphology1.01591902
87MP0004133_heterotaxia1.00752275
88MP0009697_abnormal_copulation1.00251185
89MP0002234_abnormal_pharynx_morphology0.99337156
90MP0004811_abnormal_neuron_physiology0.98409711
91MP0003634_abnormal_glial_cell0.97754670
92MP0002098_abnormal_vibrissa_morphology0.96721970
93MP0002152_abnormal_brain_morphology0.95280836
94MP0005187_abnormal_penis_morphology0.95165762
95MP0000462_abnormal_digestive_system0.94942060
96MP0001216_abnormal_epidermal_layer0.94328703
97MP0002067_abnormal_sensory_capabilities0.94075566
98MP0002229_neurodegeneration0.93788331
99MP0009384_cardiac_valve_regurgitation0.93190618
100MP0003091_abnormal_cell_migration0.92090368
101MP0002108_abnormal_muscle_morphology0.91229932
102MP0000003_abnormal_adipose_tissue0.91149479
103MP0005076_abnormal_cell_differentiation0.89735412
104MP0004142_abnormal_muscle_tone0.89447320
105MP0004233_abnormal_muscle_weight0.89400398
106MP0000383_abnormal_hair_follicle0.89270690
107MP0000627_abnormal_mammary_gland0.88870850
108MP0003633_abnormal_nervous_system0.88552977
109MP0004185_abnormal_adipocyte_glucose0.88440725
110MP0002233_abnormal_nose_morphology0.88331017
111MP0000751_myopathy0.87441727
112MP0003984_embryonic_growth_retardation0.86490687
113MP0000467_abnormal_esophagus_morphology0.86381293
114MP0000733_abnormal_muscle_development0.86071185
115MP0010771_integument_phenotype0.85552703
116MP0001501_abnormal_sleep_pattern0.85524858
117MP0002184_abnormal_innervation0.84900262
118MP0005380_embryogenesis_phenotype0.84400117
119MP0001672_abnormal_embryogenesis/_devel0.84400117
120MP0004957_abnormal_blastocyst_morpholog0.83901803
121MP0004215_abnormal_myocardial_fiber0.83770527
122MP0002088_abnormal_embryonic_growth/wei0.83387388
123MP0002086_abnormal_extraembryonic_tissu0.82482716
124MP0000566_synostosis0.82363990
125MP0003453_abnormal_keratinocyte_physiol0.80768035
126MP0005367_renal/urinary_system_phenotyp0.80423489
127MP0000516_abnormal_urinary_system0.80423489
128MP0002092_abnormal_eye_morphology0.79610363
129MP0001340_abnormal_eyelid_morphology0.77934393
130MP0003045_fibrosis0.77439670
131MP0003123_paternal_imprinting0.76878142
132MP0009703_decreased_birth_body0.76421839
133* MP0002085_abnormal_embryonic_tissue0.75829653
134MP0003861_abnormal_nervous_system0.75282097
135* MP0000534_abnormal_ureter_morphology0.75200400
136MP0003385_abnormal_body_wall0.75064112
137MP0000762_abnormal_tongue_morphology0.74759012
138MP0001697_abnormal_embryo_size0.73676217
139MP0004742_abnormal_vestibular_system0.73313036
140MP0006138_congestive_heart_failure0.72928758
141MP0001293_anophthalmia0.72669845
142MP0001661_extended_life_span0.72612473
143MP0002557_abnormal_social/conspecific_i0.71421393
144MP0003119_abnormal_digestive_system0.71111527
145MP0003943_abnormal_hepatobiliary_system0.68126304
146MP0002925_abnormal_cardiovascular_devel0.67619805
147MP0001958_emphysema0.67330929
148MP0004087_abnormal_muscle_fiber0.67096545
149MP0005551_abnormal_eye_electrophysiolog0.66854710
150* MP0004197_abnormal_fetal_growth/weight/0.66623379
151MP0001849_ear_inflammation0.66186851
152MP0005408_hypopigmentation0.66078414
153MP0000579_abnormal_nail_morphology0.65588738
154MP0005197_abnormal_uvea_morphology0.64901207
155MP0001968_abnormal_touch/_nociception0.64762278
156* MP0001286_abnormal_eye_development0.64505209
157* MP0003755_abnormal_palate_morphology0.64465749
158MP0004036_abnormal_muscle_relaxation0.64367564
159MP0002909_abnormal_adrenal_gland0.64210092
160MP0002295_abnormal_pulmonary_circulatio0.63669526
161MP0000647_abnormal_sebaceous_gland0.62763048
162MP0003806_abnormal_nucleotide_metabolis0.62750054
163MP0002168_other_aberrant_phenotype0.62431215

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.10525343
2Myokymia (HP:0002411)3.48740879
3Arterial tortuosity (HP:0005116)3.43641350
4Atonic seizures (HP:0010819)3.29175662
5Epileptic encephalopathy (HP:0200134)3.20488715
6Focal seizures (HP:0007359)3.16862874
7Degeneration of the lateral corticospinal tracts (HP:0002314)3.12462510
8Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.12462510
9Scanning speech (HP:0002168)2.98703708
10Right ventricular cardiomyopathy (HP:0011663)2.95168556
11Dysmetria (HP:0001310)2.92313792
12Sensory axonal neuropathy (HP:0003390)2.87719060
13Vascular tortuosity (HP:0004948)2.87262913
14Shallow orbits (HP:0000586)2.81901507
15Intention tremor (HP:0002080)2.80730883
16Abnormality of the corticospinal tract (HP:0002492)2.74716110
17Dysmetric saccades (HP:0000641)2.72495821
18Gaze-evoked nystagmus (HP:0000640)2.70395334
19Insidious onset (HP:0003587)2.64634252
20Termporal pattern (HP:0011008)2.64634252
21Spastic gait (HP:0002064)2.64225616
22Premature rupture of membranes (HP:0001788)2.64032895
23Progressive external ophthalmoplegia (HP:0000590)2.63078484
24Dysdiadochokinesis (HP:0002075)2.60377419
25Action tremor (HP:0002345)2.59736934
26Broad-based gait (HP:0002136)2.56254089
27Urinary bladder sphincter dysfunction (HP:0002839)2.50421561
28Aortic dissection (HP:0002647)2.49505051
29Cerebral hypomyelination (HP:0006808)2.46828819
30Resting tremor (HP:0002322)2.43640227
31Bell-shaped thorax (HP:0001591)2.41704608
32Neoplasm of the adrenal cortex (HP:0100641)2.40792770
33Papillary thyroid carcinoma (HP:0002895)2.40220236
34Ankle clonus (HP:0011448)2.37253486
35Abnormality of the lower motor neuron (HP:0002366)2.35893683
36Poor eye contact (HP:0000817)2.34678975
37Impaired vibration sensation in the lower limbs (HP:0002166)2.31758904
38Dialeptic seizures (HP:0011146)2.24961146
39Hypoplastic nipples (HP:0002557)2.24234662
40Absence seizures (HP:0002121)2.23035655
41Abnormality of the labia minora (HP:0012880)2.22872284
42Fetal akinesia sequence (HP:0001989)2.22457313
43Impaired social interactions (HP:0000735)2.22267979
44Abnormal social behavior (HP:0012433)2.22267979
45Stomach cancer (HP:0012126)2.22007610
46Subacute progressive viral hepatitis (HP:0006572)2.19425309
47Postural instability (HP:0002172)2.19404862
48Heterotopia (HP:0002282)2.19187722
49Alacrima (HP:0000522)2.18971953
50Cerebral inclusion bodies (HP:0100314)2.14926516
51Milia (HP:0001056)2.14705413
52Atrophic scars (HP:0001075)2.13927125
53Overgrowth (HP:0001548)2.11900611
54Broad metatarsal (HP:0001783)2.11779636
55Vertebral arch anomaly (HP:0008438)2.11239360
56Genetic anticipation (HP:0003743)2.09330673
57Cardiovascular calcification (HP:0011915)2.08553028
58Neurofibrillary tangles (HP:0002185)2.08458301
59Protrusio acetabuli (HP:0003179)2.05973583
60Glioma (HP:0009733)2.05563483
61Mitral stenosis (HP:0001718)2.04799199
62Urinary urgency (HP:0000012)2.03657733
63Absent frontal sinuses (HP:0002688)2.03388659
64Aplasia involving bones of the upper limbs (HP:0009823)2.02836855
65Aplasia of the phalanges of the hand (HP:0009802)2.02836855
66Aplasia involving bones of the extremities (HP:0009825)2.02836855
67Relative macrocephaly (HP:0004482)2.00041648
68Hypoplastic labia majora (HP:0000059)1.99858811
69Osteolytic defects of the hand bones (HP:0009699)1.98183697
70Osteolytic defects of the phalanges of the hand (HP:0009771)1.98183697
71Abnormal auditory evoked potentials (HP:0006958)1.97577492
72Abnormality of nail color (HP:0100643)1.96283649
73Short nail (HP:0001799)1.93698382
74Aortic aneurysm (HP:0004942)1.93427137
75Progressive cerebellar ataxia (HP:0002073)1.93030370
76Onion bulb formation (HP:0003383)1.91138617
77Coronal craniosynostosis (HP:0004440)1.90916357
78Buphthalmos (HP:0000557)1.90154652
79Turricephaly (HP:0000262)1.89436767
80Natal tooth (HP:0000695)1.88464117
81Ankyloglossia (HP:0010296)1.86817509
82Advanced eruption of teeth (HP:0006288)1.86307907
83Onycholysis (HP:0001806)1.85663710
84Cubitus valgus (HP:0002967)1.82483747
85Missing ribs (HP:0000921)1.81917704
86Flat acetabular roof (HP:0003180)1.81852106
87Hyperventilation (HP:0002883)1.81369081
88Bronchomalacia (HP:0002780)1.80560060
89Asymmetry of the thorax (HP:0001555)1.79616548
90Abnormality of the labia majora (HP:0012881)1.79237866
91Impaired vibratory sensation (HP:0002495)1.78556017
92Infantile muscular hypotonia (HP:0008947)1.78296214
93Torticollis (HP:0000473)1.77658627
94Abnormality of the distal phalanx of the thumb (HP:0009617)1.77164385
95Pulmonic stenosis (HP:0001642)1.76222971
96Ankle contracture (HP:0006466)1.76060275
97Astrocytoma (HP:0009592)1.76057844
98Abnormality of the astrocytes (HP:0100707)1.76057844
99Bundle branch block (HP:0011710)1.75991248
100Generalized tonic-clonic seizures (HP:0002069)1.75858582
101Ulnar bowing (HP:0003031)1.75115431
102Thickened helices (HP:0000391)1.74663635
103Hypoplasia of dental enamel (HP:0006297)1.72701837
104Abnormality of the periventricular white matter (HP:0002518)1.72078312
105Upper limb amyotrophy (HP:0009129)1.72028256
106Distal upper limb amyotrophy (HP:0007149)1.72028256
107Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.71408336
108Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.70879634
109Bowel incontinence (HP:0002607)1.70697278
110Deep philtrum (HP:0002002)1.70697239
111Fair hair (HP:0002286)1.70221437
112Limited hip movement (HP:0008800)1.69382332
113Abnormality of the ischium (HP:0003174)1.69270171
114Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.68632252
115Fragile skin (HP:0001030)1.68539804
116Curly hair (HP:0002212)1.67747252
117Decreased motor nerve conduction velocity (HP:0003431)1.67413048
118Clonus (HP:0002169)1.67380841
119Abnormality of the epiphyses of the hand (HP:0005924)1.66869637
120Microglossia (HP:0000171)1.66331237
121Febrile seizures (HP:0002373)1.66154039
122Fused cervical vertebrae (HP:0002949)1.65437342
123Abnormal large intestine physiology (HP:0012700)1.64833666
124Vascular calcification (HP:0004934)1.64561813
125Lower limb muscle weakness (HP:0007340)1.63617349
126Abnormality of the nasal septum (HP:0000419)1.63334258
127Hyporeflexia of lower limbs (HP:0002600)1.62666798
128Scapular winging (HP:0003691)1.62322096
129Excessive salivation (HP:0003781)1.62008835
130Drooling (HP:0002307)1.62008835
131Round ear (HP:0100830)1.61868687
132Impaired smooth pursuit (HP:0007772)1.61111588
133Neonatal short-limb short stature (HP:0008921)1.60596435
134Muscle fiber splitting (HP:0003555)1.60456591
135Sandal gap (HP:0001852)1.60341886
136Mitral valve prolapse (HP:0001634)1.60126396
137Decreased lacrimation (HP:0000633)1.59776524
138Aqueductal stenosis (HP:0002410)1.59035344
139Cervical subluxation (HP:0003308)1.58792509
140Pterygium (HP:0001059)1.58626495
141CNS hypomyelination (HP:0003429)1.58126265
142Short chin (HP:0000331)1.58009044
143Volvulus (HP:0002580)1.57757874
144Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.57145851
145Wormian bones (HP:0002645)1.56607160
146Selective tooth agenesis (HP:0001592)1.56203332
147Supranuclear gaze palsy (HP:0000605)1.56133222
148Truncal ataxia (HP:0002078)1.55968639
149Hypoplastic ischia (HP:0003175)1.55466553
150Gastroesophageal reflux (HP:0002020)1.55189185
151Abnormality of oral frenula (HP:0000190)1.54259150
152Thyroid carcinoma (HP:0002890)1.53585022
153Pointed chin (HP:0000307)1.53231115
154Abnormal pancreas size (HP:0012094)1.53083524
155Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.51621473
156Tracheal stenosis (HP:0002777)1.51542946
157Abnormality of dentin (HP:0010299)1.51065141
158Syringomyelia (HP:0003396)1.50520505
159Spinal cord lesions (HP:0100561)1.50520505
160Abnormality of the shoulder girdle musculature (HP:0001435)1.50513810
161Abnormal biliary tract morphology (HP:0012440)1.50292654
162Hypoplastic scapulae (HP:0000882)1.49002183
163Aplasia/Hypoplasia of the scapulae (HP:0006713)1.49002183
164Cystic hygroma (HP:0000476)1.48744741
165Macroorchidism (HP:0000053)1.47417412
166Chromsome breakage (HP:0040012)1.47162293
167Cutaneous finger syndactyly (HP:0010554)1.46171072
168Abnormality of the dental root (HP:0006486)1.43357351
169Taurodontia (HP:0000679)1.43357351
170Abnormality of permanent molar morphology (HP:0011071)1.43357351
171Vertebral clefting (HP:0008428)1.42467604
172Alopecia of scalp (HP:0002293)1.40228690
173Abnormality of molar (HP:0011077)1.39153524
174Abnormality of molar morphology (HP:0011070)1.39153524
175Biliary tract neoplasm (HP:0100574)1.38992134
176Acute myeloid leukemia (HP:0004808)1.38461525
177Narrow palate (HP:0000189)1.38381871
178Hypopigmentation of the fundus (HP:0007894)1.38051807

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.09937439
2MST1R3.37031281
3IRAK33.21530394
4MARK13.02190323
5OXSR12.96359139
6EPHA22.44204662
7STK392.41528717
8PNCK2.39181366
9NTRK32.22487660
10CDK192.16686320
11DAPK22.15180833
12MAP3K92.13718361
13STK38L2.09800774
14LATS12.07802894
15PLK42.07388309
16AKT31.87830880
17STK31.85895848
18PAK61.85005278
19TRPM71.82810239
20ZAK1.80297615
21MAP3K41.65733890
22FGFR21.63776816
23DDR21.61200176
24EIF2AK11.59795502
25NEK91.58067627
26PLK21.48022262
27SCYL21.46795908
28LATS21.44693761
29IRAK21.44226695
30TYRO31.42755256
31NEK61.42336157
32BRSK21.41280419
33MET1.39181411
34WNK11.38364996
35EIF2AK31.36381057
36MST41.33538019
37PRPF4B1.32887548
38PAK31.31454360
39KSR21.28121538
40ICK1.27704991
41STK241.26708598
42PRKD31.25779735
43NTRK11.25556735
44TTK1.22136233
45MYLK1.21109385
46BCR1.18511088
47ERBB31.18323692
48PAK21.16427334
49MKNK21.14215141
50CAMKK21.12368533
51PBK1.09759036
52EEF2K1.08516619
53TSSK61.08310889
54ALK1.07259129
55CAMKK11.05522539
56ROCK21.03559460
57TNIK1.00317282
58STK381.00157137
59TAF10.99746849
60RIPK10.99247239
61CASK0.95066082
62ERBB40.93833963
63PDGFRB0.93032867
64MAP3K20.91440206
65IRAK10.90379776
66CDC42BPA0.88594670
67TTN0.87016505
68MTOR0.86675595
69FGFR30.86098391
70CDK50.86024877
71MINK10.85325012
72* CAMK2B0.84783861
73EPHB20.84563302
74PIK3CA0.84107175
75WEE10.83257006
76MAP3K120.82924020
77SGK20.81505205
78PLK30.81244966
79CDK150.78515791
80KSR10.77963876
81SGK2230.77220864
82SGK4940.77220864
83WNK40.76520609
84EPHB10.74826166
85CDK140.74470524
86CDK180.73209456
87PDGFRA0.73146170
88MELK0.73139038
89CAMK1G0.72487599
90FGFR10.71757005
91BRD40.71384103
92BRSK10.70658124
93PINK10.69712417
94PRKCI0.68560093
95MAP3K100.68130723
96ROCK10.67993477
97PTK20.67370878
98BMX0.67368496
99STK110.67343979
100LMTK20.66701312
101RPS6KB20.65647738
102FRK0.65163923
103CDK11A0.64357610
104PDPK10.64034850
105MAP2K40.63714053
106PRKCH0.62293704
107NEK10.62189355
108CSNK1E0.61887806
109FER0.60720754
110MARK20.60086106
111* CAMK2D0.59584179
112SGK30.58795886
113CAMK1D0.58748768
114DMPK0.58209354
115CSNK1A1L0.57741294
116PRKCG0.56804621
117UHMK10.56335963
118MAPK100.55847607
119SGK10.55542369
120MAP3K130.51727798
121* CAMK2A0.51420466
122YES10.51293960
123ACVR1B0.50931269
124PKN20.48784505
125TAOK10.48722117
126* CAMK2G0.48479049
127CSNK1G20.48243701
128PAK40.47863331
129DAPK10.47359926
130PKN10.47321987
131MAP2K10.47051759
132BUB10.45528057
133RPS6KB10.45108053
134ARAF0.43396798
135RET0.43334529
136CDK120.42797528
137TGFBR10.42238838
138DAPK30.41798367
139PRKCE0.41583487
140PRKAA20.40822535
141ATM0.40297448
142PLK10.39801075
143BMPR20.38400220
144CHEK10.36850822
145MKNK10.36811278
146EIF2AK20.36122154
147CDK90.35319372
148AURKB0.35218106
149CDK80.34708993
150CDK60.34199559

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.80115697
2Synaptic vesicle cycle_Homo sapiens_hsa047212.60046081
3Nicotine addiction_Homo sapiens_hsa050332.52824946
4Long-term potentiation_Homo sapiens_hsa047202.27116376
5Glutamatergic synapse_Homo sapiens_hsa047242.20408632
6GABAergic synapse_Homo sapiens_hsa047272.19846908
7Circadian entrainment_Homo sapiens_hsa047132.13215508
8Amphetamine addiction_Homo sapiens_hsa050312.09584214
9Olfactory transduction_Homo sapiens_hsa047402.04462484
10Morphine addiction_Homo sapiens_hsa050321.99120411
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.97274800
12Salivary secretion_Homo sapiens_hsa049701.71360265
13Gastric acid secretion_Homo sapiens_hsa049711.62683052
14Tight junction_Homo sapiens_hsa045301.59485445
15Axon guidance_Homo sapiens_hsa043601.54696357
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.53183943
17Dopaminergic synapse_Homo sapiens_hsa047281.51969862
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50993019
19Oxytocin signaling pathway_Homo sapiens_hsa049211.49930186
20Insulin secretion_Homo sapiens_hsa049111.48698735
21Cholinergic synapse_Homo sapiens_hsa047251.47930282
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.44691929
23Small cell lung cancer_Homo sapiens_hsa052221.43813450
24Long-term depression_Homo sapiens_hsa047301.38201387
25GnRH signaling pathway_Homo sapiens_hsa049121.33650900
26Thyroid cancer_Homo sapiens_hsa052161.32805983
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31667018
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31635256
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29839449
30Cocaine addiction_Homo sapiens_hsa050301.28955584
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28013827
32ErbB signaling pathway_Homo sapiens_hsa040121.25986707
33Lysine degradation_Homo sapiens_hsa003101.25971980
34Renal cell carcinoma_Homo sapiens_hsa052111.25875037
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.25137137
36Gap junction_Homo sapiens_hsa045401.24464603
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22645461
38Dilated cardiomyopathy_Homo sapiens_hsa054141.22407312
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19794378
40ECM-receptor interaction_Homo sapiens_hsa045121.19017847
41Endometrial cancer_Homo sapiens_hsa052131.15906689
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14853189
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14322528
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.13801383
45Serotonergic synapse_Homo sapiens_hsa047261.11583517
46Non-homologous end-joining_Homo sapiens_hsa034501.11391830
47Renin secretion_Homo sapiens_hsa049241.10925726
48Calcium signaling pathway_Homo sapiens_hsa040201.07347111
49* Hippo signaling pathway_Homo sapiens_hsa043901.05790095
50Vitamin B6 metabolism_Homo sapiens_hsa007501.05704980
51Estrogen signaling pathway_Homo sapiens_hsa049151.04709170
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02888719
53Thyroid hormone synthesis_Homo sapiens_hsa049181.00560042
54Oocyte meiosis_Homo sapiens_hsa041140.99327503
55cAMP signaling pathway_Homo sapiens_hsa040240.99009952
56Vibrio cholerae infection_Homo sapiens_hsa051100.98085803
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97211526
58Taste transduction_Homo sapiens_hsa047420.96706986
59Chronic myeloid leukemia_Homo sapiens_hsa052200.94379984
60Focal adhesion_Homo sapiens_hsa045100.94013607
61Melanogenesis_Homo sapiens_hsa049160.93029852
62Glioma_Homo sapiens_hsa052140.92003004
63Sphingolipid metabolism_Homo sapiens_hsa006000.91988100
64Dorso-ventral axis formation_Homo sapiens_hsa043200.91819850
65Proteoglycans in cancer_Homo sapiens_hsa052050.91717062
66Basal cell carcinoma_Homo sapiens_hsa052170.90988805
67Type II diabetes mellitus_Homo sapiens_hsa049300.90160905
68Arginine biosynthesis_Homo sapiens_hsa002200.89674892
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88784565
70Prostate cancer_Homo sapiens_hsa052150.88311869
71Pancreatic cancer_Homo sapiens_hsa052120.88304848
72Cell cycle_Homo sapiens_hsa041100.87844741
73Collecting duct acid secretion_Homo sapiens_hsa049660.87447976
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87212003
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86301090
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.86243909
77Phototransduction_Homo sapiens_hsa047440.85469967
78Glucagon signaling pathway_Homo sapiens_hsa049220.84970099
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84687569
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84608973
81Protein digestion and absorption_Homo sapiens_hsa049740.83346155
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80615180
83Pancreatic secretion_Homo sapiens_hsa049720.80418167
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79497966
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79197827
86Ras signaling pathway_Homo sapiens_hsa040140.79082242
87Histidine metabolism_Homo sapiens_hsa003400.78297645
88MAPK signaling pathway_Homo sapiens_hsa040100.75792486
89Inositol phosphate metabolism_Homo sapiens_hsa005620.74907944
90Rap1 signaling pathway_Homo sapiens_hsa040150.74560160
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74128562
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.74082101
93Endocytosis_Homo sapiens_hsa041440.73422881
94Wnt signaling pathway_Homo sapiens_hsa043100.72564673
95Colorectal cancer_Homo sapiens_hsa052100.71893132
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.71747342
97Pathways in cancer_Homo sapiens_hsa052000.71611719
98Choline metabolism in cancer_Homo sapiens_hsa052310.71246609
99Adherens junction_Homo sapiens_hsa045200.71041366
100Bile secretion_Homo sapiens_hsa049760.70622912
101AMPK signaling pathway_Homo sapiens_hsa041520.70268195
102Non-small cell lung cancer_Homo sapiens_hsa052230.69656654
103Ether lipid metabolism_Homo sapiens_hsa005650.69296035
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68743883
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.67845254
106Ovarian steroidogenesis_Homo sapiens_hsa049130.63254808
107Hedgehog signaling pathway_Homo sapiens_hsa043400.62942514
108p53 signaling pathway_Homo sapiens_hsa041150.62754325
109N-Glycan biosynthesis_Homo sapiens_hsa005100.62657878
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62172637
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61985086
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61855602
113ABC transporters_Homo sapiens_hsa020100.59910923
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59781417
115TGF-beta signaling pathway_Homo sapiens_hsa043500.58064102
116Propanoate metabolism_Homo sapiens_hsa006400.57016646
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.56001641
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54672566
119Insulin signaling pathway_Homo sapiens_hsa049100.54030321
120Arginine and proline metabolism_Homo sapiens_hsa003300.53813356
121mRNA surveillance pathway_Homo sapiens_hsa030150.53785987
122Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52441721
123mTOR signaling pathway_Homo sapiens_hsa041500.51224928
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.50740348
125Prion diseases_Homo sapiens_hsa050200.50610255
126Butanoate metabolism_Homo sapiens_hsa006500.47379326
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.43915915
128FoxO signaling pathway_Homo sapiens_hsa040680.43309565
129MicroRNAs in cancer_Homo sapiens_hsa052060.43132163
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41977558
131Bladder cancer_Homo sapiens_hsa052190.41906304
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41892941
133Circadian rhythm_Homo sapiens_hsa047100.41504288
134Melanoma_Homo sapiens_hsa052180.40128089
135Amoebiasis_Homo sapiens_hsa051460.39605110

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