DLG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.40757563
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.30132981
3locomotory exploration behavior (GO:0035641)6.28753565
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.05620940
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.61561712
6vocalization behavior (GO:0071625)5.60459931
7synaptic vesicle exocytosis (GO:0016079)5.42899619
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.35670050
9glutamate secretion (GO:0014047)5.30957980
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.26316177
11regulation of synaptic vesicle exocytosis (GO:2000300)5.08023690
12regulation of glutamate receptor signaling pathway (GO:1900449)5.04775747
13presynaptic membrane assembly (GO:0097105)4.95880157
14protein localization to synapse (GO:0035418)4.84030067
15regulation of synapse structural plasticity (GO:0051823)4.78229514
16exploration behavior (GO:0035640)4.76618621
17presynaptic membrane organization (GO:0097090)4.76105883
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.72769534
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.67905337
20regulation of neuronal synaptic plasticity (GO:0048168)4.58087946
21layer formation in cerebral cortex (GO:0021819)4.54732611
22neurotransmitter secretion (GO:0007269)4.52603498
23neurotransmitter-gated ion channel clustering (GO:0072578)4.49413272
24regulation of synaptic vesicle transport (GO:1902803)4.49410848
25axon ensheathment in central nervous system (GO:0032291)4.43298142
26central nervous system myelination (GO:0022010)4.43298142
27neuronal action potential propagation (GO:0019227)4.36615564
28synaptic transmission, glutamatergic (GO:0035249)4.35366090
29dendritic spine morphogenesis (GO:0060997)4.28230231
30glutamate receptor signaling pathway (GO:0007215)4.23106898
31neuron cell-cell adhesion (GO:0007158)4.22675095
32gamma-aminobutyric acid transport (GO:0015812)4.15183435
33neuron-neuron synaptic transmission (GO:0007270)4.14358381
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.14136912
35long-term memory (GO:0007616)4.11239281
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.07429235
37positive regulation of membrane potential (GO:0045838)4.02874192
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.98323368
39cellular potassium ion homeostasis (GO:0030007)3.96422772
40positive regulation of synapse maturation (GO:0090129)3.86783521
41regulation of dendritic spine morphogenesis (GO:0061001)3.79711125
42proline transport (GO:0015824)3.77607067
43regulation of postsynaptic membrane potential (GO:0060078)3.75682933
44neuromuscular process controlling balance (GO:0050885)3.74878456
45sodium ion export (GO:0071436)3.70408734
46auditory behavior (GO:0031223)3.69949422
47activation of protein kinase A activity (GO:0034199)3.69565091
48regulation of synaptic plasticity (GO:0048167)3.68254398
49positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.64171335
50prepulse inhibition (GO:0060134)3.63409925
51amino acid import (GO:0043090)3.61908457
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.61413822
53neurotransmitter transport (GO:0006836)3.58004832
54regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.55604963
55regulation of synaptic transmission, glutamatergic (GO:0051966)3.51545121
56regulation of neurotransmitter secretion (GO:0046928)3.48152744
57long-term synaptic potentiation (GO:0060291)3.46122854
58dendrite morphogenesis (GO:0048813)3.45897692
59transmission of nerve impulse (GO:0019226)3.45705366
60response to auditory stimulus (GO:0010996)3.44576194
61regulation of synapse maturation (GO:0090128)3.43788985
62potassium ion homeostasis (GO:0055075)3.40793010
63cerebellar Purkinje cell differentiation (GO:0021702)3.40262697
64startle response (GO:0001964)3.38418507
65cellular sodium ion homeostasis (GO:0006883)3.35965304
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.35947090
67positive regulation of neurotransmitter secretion (GO:0001956)3.35558790
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.35359955
69positive regulation of neurotransmitter transport (GO:0051590)3.35010272
70regulation of neurotransmitter levels (GO:0001505)3.34708916
71synaptic vesicle endocytosis (GO:0048488)3.28740049
72neuron recognition (GO:0008038)3.28001640
73regulation of neurotransmitter transport (GO:0051588)3.27038283
74gamma-aminobutyric acid signaling pathway (GO:0007214)3.25499669
75adult walking behavior (GO:0007628)3.25300321
76cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.24205597
77postsynaptic membrane organization (GO:0001941)3.24109205
78glycine transport (GO:0015816)3.23034298
79G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.22544129
80potassium ion import (GO:0010107)3.22177061
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.20451659
82membrane depolarization (GO:0051899)3.20370421
83membrane hyperpolarization (GO:0060081)3.20186941
84acidic amino acid transport (GO:0015800)3.20080654
85regulation of ARF protein signal transduction (GO:0032012)3.19259314
86regulation of dendritic spine development (GO:0060998)3.19200122
87establishment of mitochondrion localization (GO:0051654)3.18367425
88negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.17328928
89cerebellar granule cell differentiation (GO:0021707)3.17039409
90behavioral defense response (GO:0002209)3.16881106
91behavioral fear response (GO:0001662)3.16881106
92regulation of vesicle fusion (GO:0031338)3.15650133
93membrane depolarization during action potential (GO:0086010)3.14175167
94positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.14023565
95response to histamine (GO:0034776)3.13709595
96learning (GO:0007612)3.13359429
97vesicle transport along microtubule (GO:0047496)3.11065411
98cell communication by electrical coupling (GO:0010644)3.10651258
99negative regulation of synaptic transmission, GABAergic (GO:0032229)3.09280773
100neuromuscular process (GO:0050905)3.08394729
101positive regulation of dendritic spine development (GO:0060999)3.08331138
102axonal fasciculation (GO:0007413)3.08221893
103neuromuscular process controlling posture (GO:0050884)3.08113636
104dendritic spine organization (GO:0097061)3.07518849
105regulation of voltage-gated calcium channel activity (GO:1901385)3.07215379
106cell differentiation in hindbrain (GO:0021533)3.07060053
107regulation of synaptic transmission, GABAergic (GO:0032228)3.06009473
108positive regulation of synaptic transmission (GO:0050806)3.05345554
109synapse assembly (GO:0007416)3.05342167
110* synaptic transmission (GO:0007268)3.03983602
111neuronal ion channel clustering (GO:0045161)3.03003852
112negative regulation of dendrite development (GO:2000171)3.02831571
113serotonin metabolic process (GO:0042428)3.02443706
114L-amino acid import (GO:0043092)3.01881362
115innervation (GO:0060384)3.01115353
116mechanosensory behavior (GO:0007638)2.99316089
117regulation of synaptic transmission (GO:0050804)2.99292267
118positive regulation of dendritic spine morphogenesis (GO:0061003)2.99243147
119behavioral response to cocaine (GO:0048148)2.98119514
120central nervous system projection neuron axonogenesis (GO:0021952)2.97951514
121detection of calcium ion (GO:0005513)2.97082929
122neuromuscular synaptic transmission (GO:0007274)2.96881411
123negative regulation of dendrite morphogenesis (GO:0050774)2.96868352
124C4-dicarboxylate transport (GO:0015740)2.95188489

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.73304739
2GBX2_23144817_ChIP-Seq_PC3_Human3.45310690
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10787304
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04393420
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02007026
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.88032567
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.74082315
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.71525679
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.71525679
10* DROSHA_22980978_ChIP-Seq_HELA_Human2.69554738
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60169660
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54562374
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53780426
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53687447
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44438953
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41694513
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.40378162
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26202640
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.26198452
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.26007143
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.21578480
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.19156083
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17747086
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.13012768
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.08134261
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07449036
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90107967
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87588748
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82887295
30* AR_21572438_ChIP-Seq_LNCaP_Human1.71062733
31* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69840683
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63963972
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.62123238
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57482285
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.57098352
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53930083
37* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41321757
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35269584
39TAF15_26573619_Chip-Seq_HEK293_Human1.34977572
40* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32577103
41* SOX2_21211035_ChIP-Seq_LN229_Gbm1.32365803
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31996123
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.31860441
44* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30954593
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.30950915
46* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30898287
47FUS_26573619_Chip-Seq_HEK293_Human1.30001786
48ZNF274_21170338_ChIP-Seq_K562_Hela1.26630487
49* AR_19668381_ChIP-Seq_PC3_Human1.26384454
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26142476
51WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25168960
52KDM2B_26808549_Chip-Seq_K562_Human1.23000933
53* STAT3_23295773_ChIP-Seq_U87_Human1.22423954
54* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21715187
55* SMAD3_21741376_ChIP-Seq_EPCs_Human1.21480812
56P300_19829295_ChIP-Seq_ESCs_Human1.19846662
57P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18643564
58* AR_25329375_ChIP-Seq_VCAP_Human1.17343183
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17012206
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16726070
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16658220
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16391497
63* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16026892
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15535488
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.14746272
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13771490
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13566665
68EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12839599
69* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11169658
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10676408
71VDR_22108803_ChIP-Seq_LS180_Human1.10548750
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09895343
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.09610532
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08502560
75SOX9_26525672_Chip-Seq_HEART_Mouse1.07883629
76YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07432980
77* TCF4_23295773_ChIP-Seq_U87_Human1.06783987
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05648865
79* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05570768
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04433286
81* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04220546
82* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03913818
83* ARNT_22903824_ChIP-Seq_MCF-7_Human1.03828047
84* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03449847
85* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02112702
86TP53_16413492_ChIP-PET_HCT116_Human1.01031811
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00522491
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.00422972
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00149383
90SMAD3_21741376_ChIP-Seq_HESCs_Human0.99348767
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98767310
92CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98748425
93* AHR_22903824_ChIP-Seq_MCF-7_Human0.98390386
94CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98022048
95* PIAS1_25552417_ChIP-Seq_VCAP_Human0.97296174
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96833107
97* KDM2B_26808549_Chip-Seq_REH_Human0.96175094
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.95913883
99GATA1_26923725_Chip-Seq_HPCs_Mouse0.95350475
100* SMAD4_21741376_ChIP-Seq_HESCs_Human0.95148119
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93504171
102KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93494404
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93478449
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93448833
105RXR_22108803_ChIP-Seq_LS180_Human0.93218392
106NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92806407
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92235684
108JUN_21703547_ChIP-Seq_K562_Human0.91340859
109* PRDM14_20953172_ChIP-Seq_ESCs_Human0.90153411
110P53_22387025_ChIP-Seq_ESCs_Mouse0.89534762
111* RUNX2_22187159_ChIP-Seq_PCA_Human0.89101778
112CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88769589
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88675553
114ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88314935
115IGF1R_20145208_ChIP-Seq_DFB_Human0.86883152
116TET1_21490601_ChIP-Seq_MESCs_Mouse0.86806980
117* RNF2_27304074_Chip-Seq_NSC_Mouse0.86608087
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84101773
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84101773
120BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82804318

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.25474458
2MP0003880_abnormal_central_pattern4.43716485
3* MP0003635_abnormal_synaptic_transmissio4.40017919
4MP0002822_catalepsy3.80387658
5MP0009745_abnormal_behavioral_response3.59015510
6MP0002063_abnormal_learning/memory/cond3.56796260
7* MP0004270_analgesia3.41069375
8MP0009046_muscle_twitch3.30206194
9MP0002064_seizures3.25312102
10MP0005423_abnormal_somatic_nervous3.01722286
11MP0002572_abnormal_emotion/affect_behav2.90855772
12MP0001486_abnormal_startle_reflex2.74032631
13MP0002272_abnormal_nervous_system2.63817533
14* MP0002734_abnormal_mechanical_nocicepti2.54652795
15* MP0001968_abnormal_touch/_nociception2.50885641
16MP0001501_abnormal_sleep_pattern2.19337586
17MP0009780_abnormal_chondrocyte_physiolo2.18063790
18MP0008569_lethality_at_weaning2.15012796
19MP0002736_abnormal_nociception_after2.10054548
20MP0002735_abnormal_chemical_nociception2.09251863
21MP0001440_abnormal_grooming_behavior2.07330190
22MP0002733_abnormal_thermal_nociception1.98529474
23MP0001970_abnormal_pain_threshold1.95047881
24MP0004811_abnormal_neuron_physiology1.90172146
25MP0002909_abnormal_adrenal_gland1.89981459
26* MP0002067_abnormal_sensory_capabilities1.88710739
27MP0004924_abnormal_behavior1.85825479
28MP0005386_behavior/neurological_phenoty1.85825479
29MP0003329_amyloid_beta_deposits1.83519641
30MP0002184_abnormal_innervation1.80622303
31MP0002557_abnormal_social/conspecific_i1.80389166
32MP0000778_abnormal_nervous_system1.78091697
33MP0003879_abnormal_hair_cell1.73045965
34MP0004858_abnormal_nervous_system1.69284661
35MP0005646_abnormal_pituitary_gland1.64726224
36MP0004885_abnormal_endolymph1.64612062
37MP0000955_abnormal_spinal_cord1.58054263
38MP0001984_abnormal_olfaction1.57335161
39MP0003633_abnormal_nervous_system1.47746241
40MP0002066_abnormal_motor_capabilities/c1.46467122
41MP0002882_abnormal_neuron_morphology1.46074578
42MP0000569_abnormal_digit_pigmentation1.42660994
43MP0003787_abnormal_imprinting1.34082095
44MP0001529_abnormal_vocalization1.23456141
45MP0001502_abnormal_circadian_rhythm1.19673152
46* MP0003631_nervous_system_phenotype1.15534721
47MP0002152_abnormal_brain_morphology1.14182511
48MP0005645_abnormal_hypothalamus_physiol1.12254585
49MP0004142_abnormal_muscle_tone1.10460847
50MP0005551_abnormal_eye_electrophysiolog1.10300704
51MP0008872_abnormal_physiological_respon1.09265265
52MP0001905_abnormal_dopamine_level1.08411228
53MP0006276_abnormal_autonomic_nervous1.06590566
54MP0008877_abnormal_DNA_methylation1.05091568
55MP0002229_neurodegeneration1.01859596
56MP0001188_hyperpigmentation1.01488428
57MP0001177_atelectasis1.01422184
58MP0003075_altered_response_to1.01266196
59MP0008874_decreased_physiological_sensi1.00851140
60MP0003123_paternal_imprinting0.99828198
61MP0003121_genomic_imprinting0.99094167
62MP0002069_abnormal_eating/drinking_beha0.95557887
63MP0004147_increased_porphyrin_level0.94318060
64MP0003690_abnormal_glial_cell0.93738010
65MP0008961_abnormal_basal_metabolism0.92670479
66MP0002090_abnormal_vision0.88894907
67MP0000920_abnormal_myelination0.88864744
68MP0004145_abnormal_muscle_electrophysio0.88498701
69MP0004085_abnormal_heartbeat0.87262525
70MP0000751_myopathy0.86960175
71MP0004742_abnormal_vestibular_system0.85711465
72MP0003634_abnormal_glial_cell0.83878299
73MP0003283_abnormal_digestive_organ0.80097900
74MP0000604_amyloidosis0.79842231
75MP0001986_abnormal_taste_sensitivity0.79821754
76MP0005499_abnormal_olfactory_system0.79393766
77MP0005394_taste/olfaction_phenotype0.79393766
78MP0005535_abnormal_body_temperature0.78283861
79MP0005409_darkened_coat_color0.77700863
80MP0000013_abnormal_adipose_tissue0.75942441
81MP0001963_abnormal_hearing_physiology0.72998898
82MP0002752_abnormal_somatic_nervous0.72292391
83MP0000631_abnormal_neuroendocrine_gland0.70310145
84MP0003122_maternal_imprinting0.69993603
85MP0010234_abnormal_vibrissa_follicle0.69777176
86* MP0003632_abnormal_nervous_system0.68905729
87MP0004215_abnormal_myocardial_fiber0.67923693
88MP0004233_abnormal_muscle_weight0.67889745
89MP0005167_abnormal_blood-brain_barrier0.67420677
90MP0003137_abnormal_impulse_conducting0.66620872
91MP0004510_myositis0.64819445
92MP0003172_abnormal_lysosome_physiology0.64382501
93MP0010386_abnormal_urinary_bladder0.64021090
94MP0001485_abnormal_pinna_reflex0.61266224
95MP0010768_mortality/aging0.60735419
96MP0004484_altered_response_of0.59912217
97MP0001346_abnormal_lacrimal_gland0.58369023
98MP0000026_abnormal_inner_ear0.57605809
99MP0005187_abnormal_penis_morphology0.56313575
100MP0004043_abnormal_pH_regulation0.56275216
101MP0001943_abnormal_respiration0.56187040
102MP0010769_abnormal_survival0.56174455
103MP0001299_abnormal_eye_distance/0.55663010
104MP0000566_synostosis0.55405373
105MP0005623_abnormal_meninges_morphology0.55151114
106MP0003861_abnormal_nervous_system0.55003406
107MP0001664_abnormal_digestion0.54621127
108MP0002638_abnormal_pupillary_reflex0.53706517
109MP0002082_postnatal_lethality0.53058272
110MP0010770_preweaning_lethality0.53058272
111MP0004130_abnormal_muscle_cell0.52469275
112MP0005253_abnormal_eye_physiology0.50712476
113MP0003956_abnormal_body_size0.49451254
114MP0000639_abnormal_adrenal_gland0.47330602
115MP0002234_abnormal_pharynx_morphology0.45198293

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.50780183
2Myokymia (HP:0002411)7.46697547
3Focal seizures (HP:0007359)5.74848039
4Visual hallucinations (HP:0002367)5.12785219
5Epileptic encephalopathy (HP:0200134)4.88055294
6Progressive cerebellar ataxia (HP:0002073)4.50271516
7Action tremor (HP:0002345)4.37241457
8Febrile seizures (HP:0002373)4.18376803
9Atonic seizures (HP:0010819)4.02372369
10Absence seizures (HP:0002121)3.95438398
11Broad-based gait (HP:0002136)3.90769843
12Poor eye contact (HP:0000817)3.86330973
13Gaze-evoked nystagmus (HP:0000640)3.75425752
14Generalized tonic-clonic seizures (HP:0002069)3.75057148
15Ankle clonus (HP:0011448)3.65924264
16Dialeptic seizures (HP:0011146)3.61709892
17Supranuclear gaze palsy (HP:0000605)3.60249674
18Papilledema (HP:0001085)3.52558977
19Dysdiadochokinesis (HP:0002075)3.49456377
20Impaired social interactions (HP:0000735)3.46557692
21Abnormal social behavior (HP:0012433)3.46557692
22Impaired vibration sensation in the lower limbs (HP:0002166)3.43553874
23Mutism (HP:0002300)3.41505821
24Depression (HP:0000716)3.36734504
25Urinary bladder sphincter dysfunction (HP:0002839)3.29950089
26Dysmetria (HP:0001310)3.21566293
27Degeneration of the lateral corticospinal tracts (HP:0002314)3.20230034
28Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.20230034
29Hyperventilation (HP:0002883)3.14236646
30Postural instability (HP:0002172)3.13094713
31Truncal ataxia (HP:0002078)3.12506681
32Genetic anticipation (HP:0003743)3.11642238
33Anxiety (HP:0000739)3.03362767
34Torticollis (HP:0000473)3.02997431
35Impaired smooth pursuit (HP:0007772)3.00671298
36Scanning speech (HP:0002168)2.97745275
37Abnormal eating behavior (HP:0100738)2.91002991
38Intention tremor (HP:0002080)2.89279046
39Dysmetric saccades (HP:0000641)2.88812698
40Abnormality of the lower motor neuron (HP:0002366)2.85655919
41Urinary urgency (HP:0000012)2.82272892
42Focal dystonia (HP:0004373)2.76554435
43Stereotypic behavior (HP:0000733)2.74940986
44Excessive salivation (HP:0003781)2.71112437
45Drooling (HP:0002307)2.71112437
46Spastic gait (HP:0002064)2.68392260
47Abnormality of binocular vision (HP:0011514)2.66181599
48Diplopia (HP:0000651)2.66181599
49Amblyopia (HP:0000646)2.65580638
50Abnormality of ocular smooth pursuit (HP:0000617)2.64979159
51Hemiparesis (HP:0001269)2.64246904
52Annular pancreas (HP:0001734)2.63442906
53Hemiplegia (HP:0002301)2.59664803
54Megalencephaly (HP:0001355)2.58798153
55Progressive inability to walk (HP:0002505)2.54849937
56Bradykinesia (HP:0002067)2.49659449
57Craniofacial dystonia (HP:0012179)2.47661712
58Neurofibrillary tangles (HP:0002185)2.44172672
59Epileptiform EEG discharges (HP:0011182)2.44028023
60Impaired vibratory sensation (HP:0002495)2.40975216
61Ventricular fibrillation (HP:0001663)2.38316574
62Abnormality of the corticospinal tract (HP:0002492)2.37965163
63EEG with generalized epileptiform discharges (HP:0011198)2.35433573
64Termporal pattern (HP:0011008)2.32549506
65Insidious onset (HP:0003587)2.32549506
66Cerebral hypomyelination (HP:0006808)2.32402042
67Fetal akinesia sequence (HP:0001989)2.31265675
68Cerebral inclusion bodies (HP:0100314)2.29406274
69Pointed chin (HP:0000307)2.28442452
70Amyotrophic lateral sclerosis (HP:0007354)2.26652476
71Status epilepticus (HP:0002133)2.26461871
72Hypsarrhythmia (HP:0002521)2.25314370
73Morphological abnormality of the pyramidal tract (HP:0002062)2.25059292
74Obstructive sleep apnea (HP:0002870)2.24992838
75Absent speech (HP:0001344)2.24505366
76Limb dystonia (HP:0002451)2.23611313
77Lower limb muscle weakness (HP:0007340)2.18626493
78Protruding tongue (HP:0010808)2.18196007
79Gait imbalance (HP:0002141)2.16468885
80Inappropriate behavior (HP:0000719)2.15130127
81Inability to walk (HP:0002540)2.13769789
82Peripheral hypomyelination (HP:0007182)2.11869246
83Generalized myoclonic seizures (HP:0002123)2.10995150
84Sleep apnea (HP:0010535)2.08327534
85Clonus (HP:0002169)2.06302687
86Spastic tetraplegia (HP:0002510)2.06151219
87Resting tremor (HP:0002322)2.05957448
88Abnormality of saccadic eye movements (HP:0000570)2.05377462
89Lower limb amyotrophy (HP:0007210)2.02946189
90Ankyloglossia (HP:0010296)2.01314870
91Gait ataxia (HP:0002066)1.99738280
92Insomnia (HP:0100785)1.99729205
93Incomplete penetrance (HP:0003829)1.97531153
94Neuronal loss in central nervous system (HP:0002529)1.97136433
95Pheochromocytoma (HP:0002666)1.95724497
96Bundle branch block (HP:0011710)1.95096137
97Abnormal EKG (HP:0003115)1.95046214
98Agitation (HP:0000713)1.92630388
99Delusions (HP:0000746)1.91918520
100Polyphagia (HP:0002591)1.90834983
101Blue irides (HP:0000635)1.88456971
102Abnormality of the labia minora (HP:0012880)1.87393577
103Syncope (HP:0001279)1.84174645
104Prolonged QT interval (HP:0001657)1.83294712
105Lower limb asymmetry (HP:0100559)1.82715370
106Paraplegia (HP:0010550)1.81828974
107Rigidity (HP:0002063)1.81780854
108Hypoplasia of the corpus callosum (HP:0002079)1.81420003
109Increased circulating renin level (HP:0000848)1.81184926
110Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80582084
111Intellectual disability, profound (HP:0002187)1.80436721
112Spastic tetraparesis (HP:0001285)1.80406692
113Akinesia (HP:0002304)1.78585410
114Apathy (HP:0000741)1.76564138
115Abnormality of salivation (HP:0100755)1.76545435
116Alacrima (HP:0000522)1.75944257
117Spastic paraplegia (HP:0001258)1.75726003
118CNS hypomyelination (HP:0003429)1.75672214
119Aqueductal stenosis (HP:0002410)1.71398529
120Tetraplegia (HP:0002445)1.69775178

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.59933468
2NTRK34.31640306
3MAP3K93.93863117
4MARK13.82846288
5MAP3K42.88070973
6DAPK22.82309302
7MINK12.69321494
8MAP2K72.34647981
9PAK62.31838138
10CAMKK12.24284949
11NTRK22.21764673
12PRKD32.21607935
13KSR22.15205017
14NTRK11.77891382
15MAP2K41.74665611
16DAPK11.67372812
17TNIK1.63415647
18KSR11.63157006
19CDK51.61215235
20RIPK41.57372095
21CAMKK21.46302848
22PRPF4B1.43519764
23STK381.40810923
24MAP3K121.37078062
25CDK191.36466752
26CASK1.36163064
27TAOK11.34337703
28SIK21.30749181
29MAPK131.29587023
30MAP3K21.28968611
31FRK1.28917047
32TYRO31.21826323
33PRKCG1.19277428
34PLK21.16600439
35FES1.15025197
36PHKG11.14619810
37PHKG21.14619810
38GRK51.08496585
39WNK31.00300779
40STK110.99816015
41MAP3K130.99356366
42CAMK10.99293131
43UHMK10.97532094
44LATS20.96266747
45SGK4940.96072073
46SGK2230.96072073
47ARAF0.95389341
48CDK180.94571687
49CDK150.93424883
50PRKCH0.92824380
51RET0.88867529
52CDK140.88432131
53CAMK2A0.88104247
54MARK20.87316465
55RIPK10.86275121
56ALK0.85706845
57SGK20.84948154
58CDK11A0.81321710
59SGK30.81239704
60PINK10.79947930
61RAF10.78988712
62PNCK0.76649223
63PDK10.74751177
64SGK10.74185359
65CAMK2B0.72880190
66CSNK1G20.72791158
67BCR0.69873200
68CSNK1A1L0.69403650
69PAK30.68316835
70STK390.67508689
71OXSR10.67166123
72PDPK10.66286104
73DYRK20.65424705
74LMTK20.65381821
75AKT30.64120611
76NEK10.63376065
77CSNK1G30.62938588
78DYRK1A0.62591473
79CCNB10.55991750
80PRKCZ0.55723597
81PTK2B0.55487511
82SCYL20.55281259
83CSNK1G10.54271099
84RPS6KA30.54074230
85BMPR20.52342423
86MAP3K10.50902422
87CAMK40.50428726
88NEK60.50162221
89CSNK1D0.47950083
90WNK10.47590493
91PRKG10.47580395
92CDC42BPA0.46238987
93CAMK1G0.45997296
94MAP3K70.45000490
95* FYN0.43730941
96MAPK100.43554597
97TNK20.43257939
98ROCK20.42349962
99BRSK10.41771225
100PRKCE0.41645430
101DMPK0.40718899
102DAPK30.40636562
103CSNK1A10.39632771
104PRKACA0.39434465
105ERBB30.38925535
106MAPK120.38763613
107CSNK1E0.37708932
108CAMK2G0.37604020
109PRKCA0.37229616
110CAMK2D0.36348664
111FGFR20.35297348
112MAP2K10.34905876
113MAP3K60.34599884
114MAP4K20.34057677
115PRKCB0.33776424
116RPS6KA20.33248729
117GSK3B0.32464927
118TRIM280.31958097
119PKN10.30978257
120LIMK10.30536995
121ERBB20.29629889
122MAPK80.28676781

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.48393618
2Synaptic vesicle cycle_Homo sapiens_hsa047213.11385078
3Olfactory transduction_Homo sapiens_hsa047402.96354998
4Circadian entrainment_Homo sapiens_hsa047132.79033321
5GABAergic synapse_Homo sapiens_hsa047272.70832531
6Long-term potentiation_Homo sapiens_hsa047202.68437177
7Glutamatergic synapse_Homo sapiens_hsa047242.65757947
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.60800029
9Morphine addiction_Homo sapiens_hsa050322.57485167
10Amphetamine addiction_Homo sapiens_hsa050312.43893403
11Dopaminergic synapse_Homo sapiens_hsa047282.20260570
12Salivary secretion_Homo sapiens_hsa049702.18832084
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.15619642
14Cholinergic synapse_Homo sapiens_hsa047252.02627624
15Insulin secretion_Homo sapiens_hsa049111.95594170
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.93859600
17Gastric acid secretion_Homo sapiens_hsa049711.91004124
18Renin secretion_Homo sapiens_hsa049241.71311298
19Cocaine addiction_Homo sapiens_hsa050301.70876700
20Oxytocin signaling pathway_Homo sapiens_hsa049211.70814686
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70682900
22Long-term depression_Homo sapiens_hsa047301.69887366
23Taste transduction_Homo sapiens_hsa047421.55922484
24Calcium signaling pathway_Homo sapiens_hsa040201.54573032
25Serotonergic synapse_Homo sapiens_hsa047261.54418526
26GnRH signaling pathway_Homo sapiens_hsa049121.45442030
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42976007
28Nitrogen metabolism_Homo sapiens_hsa009101.39945347
29Gap junction_Homo sapiens_hsa045401.39881833
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31517375
31cAMP signaling pathway_Homo sapiens_hsa040241.31422510
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31314740
33Type II diabetes mellitus_Homo sapiens_hsa049301.25913583
34Glioma_Homo sapiens_hsa052141.20529334
35Estrogen signaling pathway_Homo sapiens_hsa049151.18489871
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18161105
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16777486
38Axon guidance_Homo sapiens_hsa043601.08967442
39ErbB signaling pathway_Homo sapiens_hsa040121.07767640
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07144879
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06877823
42Phototransduction_Homo sapiens_hsa047441.06444875
43Melanogenesis_Homo sapiens_hsa049161.00722067
44Collecting duct acid secretion_Homo sapiens_hsa049660.97891466
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.92870690
46Phospholipase D signaling pathway_Homo sapiens_hsa040720.90983891
47Oocyte meiosis_Homo sapiens_hsa041140.89670308
48Pancreatic secretion_Homo sapiens_hsa049720.86161286
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85011293
50Vitamin B6 metabolism_Homo sapiens_hsa007500.82661413
51Dorso-ventral axis formation_Homo sapiens_hsa043200.82133819
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79804437
53Thyroid hormone synthesis_Homo sapiens_hsa049180.78662776
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77634908
55Choline metabolism in cancer_Homo sapiens_hsa052310.74526167
56Dilated cardiomyopathy_Homo sapiens_hsa054140.74117656
57MAPK signaling pathway_Homo sapiens_hsa040100.72370271
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71496410
59Cardiac muscle contraction_Homo sapiens_hsa042600.70847978
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.70511767
61VEGF signaling pathway_Homo sapiens_hsa043700.67944227
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67816517
63mTOR signaling pathway_Homo sapiens_hsa041500.66365044
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65708203
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62658390
66Rap1 signaling pathway_Homo sapiens_hsa040150.61298862
67Vibrio cholerae infection_Homo sapiens_hsa051100.60630351
68Ras signaling pathway_Homo sapiens_hsa040140.60479107
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.59268494
70Endometrial cancer_Homo sapiens_hsa052130.57499356
71Histidine metabolism_Homo sapiens_hsa003400.56838995
72Non-small cell lung cancer_Homo sapiens_hsa052230.55919265
73Glucagon signaling pathway_Homo sapiens_hsa049220.55602769
74Bile secretion_Homo sapiens_hsa049760.55224088
75beta-Alanine metabolism_Homo sapiens_hsa004100.54626662
76Alcoholism_Homo sapiens_hsa050340.54621944
77Endocytosis_Homo sapiens_hsa041440.54531676
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54514813
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52772918
80Circadian rhythm_Homo sapiens_hsa047100.52119812
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51440352
82Inositol phosphate metabolism_Homo sapiens_hsa005620.51208486
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49452485
84Renal cell carcinoma_Homo sapiens_hsa052110.47585742
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45984667
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45413859
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45239319
88Butanoate metabolism_Homo sapiens_hsa006500.44538434
89Chemokine signaling pathway_Homo sapiens_hsa040620.44309167
90Fatty acid biosynthesis_Homo sapiens_hsa000610.43166555
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43046328
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42946888
93Type I diabetes mellitus_Homo sapiens_hsa049400.42531605
94Insulin signaling pathway_Homo sapiens_hsa049100.41923290
95Tight junction_Homo sapiens_hsa045300.40180719
96Wnt signaling pathway_Homo sapiens_hsa043100.39589231
97Ovarian steroidogenesis_Homo sapiens_hsa049130.38128138
98Prion diseases_Homo sapiens_hsa050200.35670344
99Regulation of autophagy_Homo sapiens_hsa041400.35342501
100ABC transporters_Homo sapiens_hsa020100.34648220
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33333198
102Ether lipid metabolism_Homo sapiens_hsa005650.33029351
103Arginine and proline metabolism_Homo sapiens_hsa003300.32934143
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31571417
105Colorectal cancer_Homo sapiens_hsa052100.31567018
106African trypanosomiasis_Homo sapiens_hsa051430.30759079
107Platelet activation_Homo sapiens_hsa046110.30715143
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30573370
109Alzheimers disease_Homo sapiens_hsa050100.30026758
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29905520
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29882254
112Mineral absorption_Homo sapiens_hsa049780.28651150
113* Hippo signaling pathway_Homo sapiens_hsa043900.27806306
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27772477
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26767552
116AMPK signaling pathway_Homo sapiens_hsa041520.25400919

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