DLG3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.19970108
2locomotory exploration behavior (GO:0035641)6.11782415
3synaptic vesicle maturation (GO:0016188)5.94808878
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.77898798
5vocalization behavior (GO:0071625)5.70631478
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.48571384
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.42059817
8synaptic vesicle exocytosis (GO:0016079)5.19920765
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.19515552
10regulation of glutamate receptor signaling pathway (GO:1900449)5.18057163
11glutamate secretion (GO:0014047)5.16096436
12regulation of synaptic vesicle exocytosis (GO:2000300)4.85980390
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.79941683
14regulation of long-term neuronal synaptic plasticity (GO:0048169)4.76914548
15exploration behavior (GO:0035640)4.74757657
16protein localization to synapse (GO:0035418)4.70033774
17regulation of neuronal synaptic plasticity (GO:0048168)4.68579671
18layer formation in cerebral cortex (GO:0021819)4.55238574
19dendritic spine morphogenesis (GO:0060997)4.51892156
20neurotransmitter secretion (GO:0007269)4.35947735
21regulation of synaptic vesicle transport (GO:1902803)4.35875923
22regulation of synapse structural plasticity (GO:0051823)4.28931162
23glutamate receptor signaling pathway (GO:0007215)4.24886213
24synaptic transmission, glutamatergic (GO:0035249)4.23815008
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.18853111
26neuronal action potential propagation (GO:0019227)4.18119685
27neuron cell-cell adhesion (GO:0007158)4.12030468
28neurotransmitter-gated ion channel clustering (GO:0072578)4.11285542
29long-term memory (GO:0007616)4.03826587
30positive regulation of synapse maturation (GO:0090129)4.01726531
31regulation of dendritic spine morphogenesis (GO:0061001)3.94554512
32neuron-neuron synaptic transmission (GO:0007270)3.94114195
33regulation of excitatory postsynaptic membrane potential (GO:0060079)3.86549425
34gamma-aminobutyric acid transport (GO:0015812)3.82478327
35proline transport (GO:0015824)3.82050385
36positive regulation of membrane potential (GO:0045838)3.77273755
37regulation of synaptic plasticity (GO:0048167)3.77244296
38cellular potassium ion homeostasis (GO:0030007)3.72388944
39neuron recognition (GO:0008038)3.69334060
40neuromuscular process controlling balance (GO:0050885)3.67228651
41regulation of postsynaptic membrane potential (GO:0060078)3.63303301
42cerebellar granule cell differentiation (GO:0021707)3.62102656
43activation of protein kinase A activity (GO:0034199)3.58021448
44apical protein localization (GO:0045176)3.55013300
45G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.53951633
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.53482742
47axonal fasciculation (GO:0007413)3.52082863
48dendritic spine organization (GO:0097061)3.51014718
49sodium ion export (GO:0071436)3.49907804
50long-term synaptic potentiation (GO:0060291)3.46700305
51auditory behavior (GO:0031223)3.45981366
52neurotransmitter transport (GO:0006836)3.44660907
53positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.32893545
54synaptic vesicle endocytosis (GO:0048488)3.31201553
55transmission of nerve impulse (GO:0019226)3.28915616
56positive regulation of dendritic spine morphogenesis (GO:0061003)3.28378106
57dendrite morphogenesis (GO:0048813)3.26919217
58positive regulation of neurotransmitter secretion (GO:0001956)3.26710565
59regulation of dendritic spine development (GO:0060998)3.25696315
60regulation of neurotransmitter secretion (GO:0046928)3.24835890
61cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.24786407
62behavioral fear response (GO:0001662)3.23826567
63behavioral defense response (GO:0002209)3.23826567
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.21951367
65gamma-aminobutyric acid signaling pathway (GO:0007214)3.21347208
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.21086784
67regulation of neurotransmitter levels (GO:0001505)3.19793564
68cell communication by electrical coupling (GO:0010644)3.18161643
69regulation of vesicle fusion (GO:0031338)3.17508336
70regulation of female receptivity (GO:0045924)3.15533817
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.15344204
72postsynaptic membrane organization (GO:0001941)3.15093007
73ephrin receptor signaling pathway (GO:0048013)3.14790721
74positive regulation of dendritic spine development (GO:0060999)3.14346261
75vesicle transport along microtubule (GO:0047496)3.13039177
76innervation (GO:0060384)3.12902191
77response to auditory stimulus (GO:0010996)3.12567288
78response to histamine (GO:0034776)3.11538814
79positive regulation of neurotransmitter transport (GO:0051590)3.08593720
80learning (GO:0007612)3.05430838
81cerebellar Purkinje cell differentiation (GO:0021702)3.03346360
82prepulse inhibition (GO:0060134)3.02741662
83fear response (GO:0042596)3.02463643
84neuronal ion channel clustering (GO:0045161)3.02055314
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.01764963
86regulation of neurotransmitter transport (GO:0051588)2.99719771
87paraxial mesoderm development (GO:0048339)2.98017814
88regulation of clathrin-mediated endocytosis (GO:2000369)2.97382251
89membrane depolarization (GO:0051899)2.97365550
90neuromuscular process (GO:0050905)2.97319907
91chemosensory behavior (GO:0007635)2.95927769
92negative regulation of synaptic transmission, GABAergic (GO:0032229)2.95617113
93regulation of synaptic transmission (GO:0050804)2.94612851
94regulation of synapse maturation (GO:0090128)2.94320900
95intraspecies interaction between organisms (GO:0051703)2.93739723
96social behavior (GO:0035176)2.93739723
97positive regulation of synaptic transmission (GO:0050806)2.91634205
98glycine transport (GO:0015816)2.90563452
99central nervous system projection neuron axonogenesis (GO:0021952)2.90491345
100regulation of ARF protein signal transduction (GO:0032012)2.90082873
101long term synaptic depression (GO:0060292)2.89897938
102membrane hyperpolarization (GO:0060081)2.89841849
103cell migration in hindbrain (GO:0021535)2.88602410
104cerebellar Purkinje cell layer development (GO:0021680)2.85276382
105synapse assembly (GO:0007416)2.84900656
106presynaptic membrane assembly (GO:0097105)2.76918278
107mating behavior (GO:0007617)2.74135496
108cell communication involved in cardiac conduction (GO:0086065)2.71827340
109presynaptic membrane organization (GO:0097090)2.68800043
110asymmetric protein localization (GO:0008105)2.67556528
111heterochromatin organization (GO:0070828)2.61289628
112regulation of posttranscriptional gene silencing (GO:0060147)2.61212586
113regulation of gene silencing by miRNA (GO:0060964)2.61212586
114regulation of gene silencing by RNA (GO:0060966)2.61212586
115planar cell polarity pathway involved in neural tube closure (GO:0090179)2.58313001
116pre-miRNA processing (GO:0031054)2.55835974
117cytoskeletal anchoring at plasma membrane (GO:0007016)2.50051933
118protein complex localization (GO:0031503)2.47893214
119cochlea development (GO:0090102)2.47555059
120notochord development (GO:0030903)2.46267863
121establishment or maintenance of monopolar cell polarity (GO:0061339)2.45201673
122establishment of monopolar cell polarity (GO:0061162)2.45201673
123bundle of His cell to Purkinje myocyte communication (GO:0086069)2.43291414
124neuron remodeling (GO:0016322)2.41579630
125camera-type eye morphogenesis (GO:0048593)2.35461627
126body morphogenesis (GO:0010171)2.34774164
127establishment of apical/basal cell polarity (GO:0035089)2.33180801
128regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.31885357
129adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.30264585
130* establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.28576353
131cellular sodium ion homeostasis (GO:0006883)2.27517535
132regulation of heart rate by cardiac conduction (GO:0086091)2.24097155
133lung epithelium development (GO:0060428)2.22693443
134axonemal dynein complex assembly (GO:0070286)2.21696098
135* establishment or maintenance of bipolar cell polarity (GO:0061245)2.21330601
136* establishment or maintenance of apical/basal cell polarity (GO:0035088)2.21330601
137negative regulation of dendrite morphogenesis (GO:0050774)2.20986880
138regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.19335439
139cell-cell junction maintenance (GO:0045217)2.19223306
140negative regulation of microtubule polymerization (GO:0031115)2.16373445
141potassium ion homeostasis (GO:0055075)2.16308242
142desmosome organization (GO:0002934)2.14254729
143dopamine receptor signaling pathway (GO:0007212)2.13044097
144inner ear receptor cell development (GO:0060119)2.13033671
145intestinal epithelial cell development (GO:0060576)2.11947986
146lateral sprouting from an epithelium (GO:0060601)2.09865250
147cellular component maintenance (GO:0043954)2.08620308
148embryonic body morphogenesis (GO:0010172)2.07196226
149regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.05106257
150mitotic chromosome condensation (GO:0007076)2.03844603
151positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.02790573
152positive regulation of cell cycle G2/M phase transition (GO:1902751)2.02628017
153positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.02628017
154negative regulation of keratinocyte proliferation (GO:0010839)2.00229715
155positive regulation of synapse assembly (GO:0051965)1.99230630
156amino acid import (GO:0043090)1.99053315
157cardiac conduction (GO:0061337)1.98739804
158positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)1.98561754
159substrate-independent telencephalic tangential interneuron migration (GO:0021843)1.97706892
160substrate-independent telencephalic tangential migration (GO:0021826)1.97706892

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.73450471
2GBX2_23144817_ChIP-Seq_PC3_Human3.08795220
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08000590
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05617089
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04380608
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.83399913
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79266886
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79266886
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69503699
10REST_21632747_ChIP-Seq_MESCs_Mouse2.64467864
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61432532
12DROSHA_22980978_ChIP-Seq_HELA_Human2.58037016
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51498662
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49483018
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49468878
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.47284358
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45343320
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.30168515
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.24450890
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.23618659
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23122024
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.21249601
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.15782147
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12619121
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.12409061
26AR_21909140_ChIP-Seq_LNCAP_Human2.10513940
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.10025729
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02982171
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00526597
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96498717
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91032947
32GATA1_26923725_Chip-Seq_HPCs_Mouse1.87957028
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.87739981
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.79473475
35AR_21572438_ChIP-Seq_LNCaP_Human1.78118016
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.73431668
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72317510
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59610974
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.55977065
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55661661
41SMAD4_21799915_ChIP-Seq_A2780_Human1.50730466
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49640336
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46497741
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.43003940
45ZNF274_21170338_ChIP-Seq_K562_Hela1.41961262
46RING1B_27294783_Chip-Seq_ESCs_Mouse1.40467078
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40152944
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37529408
49E2F7_22180533_ChIP-Seq_HELA_Human1.35679447
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34504352
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33423278
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33017390
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32625460
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29281526
55WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28942650
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.28802630
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28578505
58RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28316155
59KDM2B_26808549_Chip-Seq_K562_Human1.28008846
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.27428023
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26951434
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26951434
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26951434
64* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26545421
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.25634787
66AR_19668381_ChIP-Seq_PC3_Human1.25245947
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23685719
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21526355
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21275911
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19697438
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.19624328
72ISL1_27105846_Chip-Seq_CPCs_Mouse1.18741358
73TAF15_26573619_Chip-Seq_HEK293_Human1.18432548
74CDX2_20551321_ChIP-Seq_CACO-2_Human1.17518199
75OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.17023949
76EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16750200
77AR_25329375_ChIP-Seq_VCAP_Human1.16573564
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15780842
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.15542327
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15466945
81NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.13545108
82KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12733784
83P300_19829295_ChIP-Seq_ESCs_Human1.12192232
84STAT3_23295773_ChIP-Seq_U87_Human1.11593824
85AHR_22903824_ChIP-Seq_MCF-7_Human1.11239430
86NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.10536918
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.10063199
88SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09917461
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07417857
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06350743
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05758318
92CREB1_26743006_Chip-Seq_LNCaP_Human1.05264272
93POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.04543774
94ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04530505
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03973921
96MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03659513
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.03248223
98ZNF263_19887448_ChIP-Seq_K562_Human1.03217297
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.02785215
100P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02696587
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02587058
102SMAD3_21741376_ChIP-Seq_HESCs_Human1.02128928
103CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01614651
104TP53_16413492_ChIP-PET_HCT116_Human1.01046529
105SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00298530
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99917195
107RXR_22108803_ChIP-Seq_LS180_Human0.99246581
108ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99188798
109POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98458515
110RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96427924
111TCF4_23295773_ChIP-Seq_U87_Human0.96301682
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96149952
113SMAD4_21741376_ChIP-Seq_HESCs_Human0.95579557
114ESR1_20079471_ChIP-ChIP_T-47D_Human0.95454975
115NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95332578
116SOX2_16153702_ChIP-ChIP_HESCs_Human0.94954644
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94802660
118* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.93857635
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93606223
120GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93319264
121RACK7_27058665_Chip-Seq_MCF-7_Human0.93157653
122TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92075708
123TCF3_18692474_ChIP-Seq_MESCs_Mouse0.91851547
124FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.91761107
125SMAD3_21741376_ChIP-Seq_ESCs_Human0.91681692
126RNF2_27304074_Chip-Seq_NSC_Mouse0.91377398
127POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91127727
128SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90890500
129KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90834048
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90740139
131BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90161148
132NANOG_21062744_ChIP-ChIP_HESCs_Human0.89336500
133SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89318486
134* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89258622
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89055072
136TP53_18474530_ChIP-ChIP_U2OS_Human0.88170266
137ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88121142
138TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.87861152
139RUNX1_27514584_Chip-Seq_MCF-7_Human0.87816467
140SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87774040
141PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87625062
142TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87494660
143* RUNX2_22187159_ChIP-Seq_PCA_Human0.86636518
144CHD1_26751641_Chip-Seq_LNCaP_Human0.86289035
145CTCF_27219007_Chip-Seq_Bcells_Human0.86110696
146TET1_21490601_ChIP-Seq_MESCs_Mouse0.85261061
147PRDM14_20953172_ChIP-Seq_ESCs_Human0.84144812
148BCAT_22108803_ChIP-Seq_LS180_Human0.84091667
149CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82493305

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.36887500
2MP0003880_abnormal_central_pattern4.55114567
3* MP0003635_abnormal_synaptic_transmissio4.31164194
4MP0004270_analgesia3.75813629
5* MP0002063_abnormal_learning/memory/cond3.49851213
6MP0009745_abnormal_behavioral_response3.44333682
7MP0000566_synostosis3.34990522
8MP0002822_catalepsy3.23051126
9MP0002064_seizures3.08202328
10MP0002572_abnormal_emotion/affect_behav2.76989269
11MP0009046_muscle_twitch2.73203310
12MP0001968_abnormal_touch/_nociception2.69169415
13MP0005423_abnormal_somatic_nervous2.52261328
14MP0009780_abnormal_chondrocyte_physiolo2.51563796
15MP0001486_abnormal_startle_reflex2.42108773
16MP0002734_abnormal_mechanical_nocicepti2.41414483
17MP0002272_abnormal_nervous_system2.37566440
18MP0001501_abnormal_sleep_pattern2.24347299
19MP0009379_abnormal_foot_pigmentation2.11973553
20MP0001440_abnormal_grooming_behavior2.07824755
21MP0003329_amyloid_beta_deposits1.97354416
22MP0002909_abnormal_adrenal_gland1.93008421
23MP0002736_abnormal_nociception_after1.92949283
24MP0010234_abnormal_vibrissa_follicle1.88500701
25MP0003890_abnormal_embryonic-extraembry1.85798711
26MP0000778_abnormal_nervous_system1.85626247
27MP0002735_abnormal_chemical_nociception1.84509168
28MP0002733_abnormal_thermal_nociception1.83554350
29MP0004885_abnormal_endolymph1.81584922
30MP0010030_abnormal_orbit_morphology1.80683087
31MP0004811_abnormal_neuron_physiology1.79092318
32MP0001346_abnormal_lacrimal_gland1.76203245
33MP0008569_lethality_at_weaning1.75342077
34MP0004858_abnormal_nervous_system1.74533496
35MP0002557_abnormal_social/conspecific_i1.73862252
36MP0006292_abnormal_olfactory_placode1.73304082
37MP0002184_abnormal_innervation1.71877084
38MP0001970_abnormal_pain_threshold1.71190193
39MP0002067_abnormal_sensory_capabilities1.68014956
40MP0003879_abnormal_hair_cell1.63649310
41MP0003693_abnormal_embryo_hatching1.63552229
42MP0005386_behavior/neurological_phenoty1.60097563
43MP0004924_abnormal_behavior1.60097563
44MP0000955_abnormal_spinal_cord1.49854546
45MP0003941_abnormal_skin_development1.49568366
46MP0000579_abnormal_nail_morphology1.49444493
47MP0003937_abnormal_limbs/digits/tail_de1.49174400
48MP0004264_abnormal_extraembryonic_tissu1.42361962
49MP0003787_abnormal_imprinting1.38461158
50MP0003938_abnormal_ear_development1.37674261
51MP0005646_abnormal_pituitary_gland1.34681283
52MP0002882_abnormal_neuron_morphology1.34221129
53* MP0002066_abnormal_motor_capabilities/c1.34134091
54MP0003283_abnormal_digestive_organ1.33066734
55MP0009672_abnormal_birth_weight1.30455417
56MP0002249_abnormal_larynx_morphology1.29444888
57MP0003121_genomic_imprinting1.27843220
58MP0003633_abnormal_nervous_system1.26908066
59MP0002653_abnormal_ependyma_morphology1.24634985
60MP0001293_anophthalmia1.22711593
61MP0001984_abnormal_olfaction1.17841223
62MP0001177_atelectasis1.16396343
63* MP0002152_abnormal_brain_morphology1.13920115
64MP0002796_impaired_skin_barrier1.12103294
65MP0002697_abnormal_eye_size1.12097048
66MP0004957_abnormal_blastocyst_morpholog1.11913162
67MP0002233_abnormal_nose_morphology1.08139911
68MP0003631_nervous_system_phenotype1.07292249
69MP0001502_abnormal_circadian_rhythm1.05783084
70MP0003942_abnormal_urinary_system1.05174165
71* MP0002084_abnormal_developmental_patter1.04614812
72MP0003315_abnormal_perineum_morphology1.04405393
73MP0003122_maternal_imprinting1.04130361
74MP0010678_abnormal_skin_adnexa1.03999334
75MP0000049_abnormal_middle_ear1.02131926
76MP0000013_abnormal_adipose_tissue1.01917839
77MP0006276_abnormal_autonomic_nervous1.00297330
78MP0000569_abnormal_digit_pigmentation0.99118589
79MP0002069_abnormal_eating/drinking_beha0.98639150
80MP0008961_abnormal_basal_metabolism0.98525115
81MP0008877_abnormal_DNA_methylation0.98325852
82MP0000462_abnormal_digestive_system0.98117270
83MP0002098_abnormal_vibrissa_morphology0.97567095
84MP0002085_abnormal_embryonic_tissue0.97193889
85MP0003075_altered_response_to0.96186251
86MP0008872_abnormal_physiological_respon0.94296175
87MP0005187_abnormal_penis_morphology0.93487050
88MP0004133_heterotaxia0.93441096
89MP0009053_abnormal_anal_canal0.92549005
90MP0001529_abnormal_vocalization0.92497864
91MP0000534_abnormal_ureter_morphology0.92163044
92MP0008789_abnormal_olfactory_epithelium0.91732767
93MP0000762_abnormal_tongue_morphology0.91076352
94MP0002089_abnormal_postnatal_growth/wei0.89891669
95MP0008874_decreased_physiological_sensi0.89084517
96MP0003755_abnormal_palate_morphology0.86563913
97MP0005645_abnormal_hypothalamus_physiol0.86204688
98MP0002116_abnormal_craniofacial_bone0.85848608
99MP0000383_abnormal_hair_follicle0.84672692
100MP0000604_amyloidosis0.83929697
101MP0005394_taste/olfaction_phenotype0.83835839
102MP0005499_abnormal_olfactory_system0.83835839
103MP0005623_abnormal_meninges_morphology0.83743844
104MP0001286_abnormal_eye_development0.83489537
105MP0004085_abnormal_heartbeat0.83166949
106MP0004142_abnormal_muscle_tone0.82280001
107MP0009703_decreased_birth_body0.81272981
108MP0001188_hyperpigmentation0.80687355
109MP0001905_abnormal_dopamine_level0.80646375
110MP0010386_abnormal_urinary_bladder0.79526336
111MP0003632_abnormal_nervous_system0.79425859
112MP0000678_abnormal_parathyroid_gland0.78622250
113* MP0002081_perinatal_lethality0.78559121
114MP0003385_abnormal_body_wall0.78390937
115MP0000631_abnormal_neuroendocrine_gland0.77276077
116MP0001730_embryonic_growth_arrest0.76917415
117MP0005380_embryogenesis_phenotype0.76330138
118MP0001672_abnormal_embryogenesis/_devel0.76330138
119MP0001664_abnormal_digestion0.75972159
120MP0002160_abnormal_reproductive_system0.75588571
121MP0004145_abnormal_muscle_electrophysio0.74267151
122MP0005535_abnormal_body_temperature0.73215560
123MP0002229_neurodegeneration0.72973398
124MP0002234_abnormal_pharynx_morphology0.72272305
125MP0000751_myopathy0.71424729
126MP0003123_paternal_imprinting0.71315578
127MP0000537_abnormal_urethra_morphology0.71141243
128MP0001963_abnormal_hearing_physiology0.68956277
129MP0004043_abnormal_pH_regulation0.68317636
130MP0005167_abnormal_blood-brain_barrier0.66158690
131* MP0003861_abnormal_nervous_system0.65469781
132MP0001485_abnormal_pinna_reflex0.65111815
133MP0003690_abnormal_glial_cell0.64362048
134MP0004484_altered_response_of0.63960285
135MP0003634_abnormal_glial_cell0.63654812
136MP0005551_abnormal_eye_electrophysiolog0.63302955
137MP0002090_abnormal_vision0.62611982
138MP0002837_dystrophic_cardiac_calcinosis0.62544298
139MP0004742_abnormal_vestibular_system0.60811239
140MP0004233_abnormal_muscle_weight0.60465337
141MP0003119_abnormal_digestive_system0.58646165
142MP0002752_abnormal_somatic_nervous0.57994509
143MP0002876_abnormal_thyroid_physiology0.57820494
144MP0003137_abnormal_impulse_conducting0.55600992
145MP0001943_abnormal_respiration0.54848602
146MP0001299_abnormal_eye_distance/0.53236336
147MP0010769_abnormal_survival0.52986287
148MP0005409_darkened_coat_color0.52537287

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.64987392
2Myokymia (HP:0002411)6.75603662
3Focal seizures (HP:0007359)5.80115536
4Visual hallucinations (HP:0002367)5.36792702
5Epileptic encephalopathy (HP:0200134)4.44272613
6Atonic seizures (HP:0010819)4.04495673
7Absence seizures (HP:0002121)3.99554683
8Progressive cerebellar ataxia (HP:0002073)3.92946953
9Action tremor (HP:0002345)3.76709005
10Febrile seizures (HP:0002373)3.75293012
11Generalized tonic-clonic seizures (HP:0002069)3.70406452
12Dialeptic seizures (HP:0011146)3.61817404
13Poor eye contact (HP:0000817)3.45717270
14Impaired vibration sensation in the lower limbs (HP:0002166)3.40145973
15Broad-based gait (HP:0002136)3.38632781
16Abnormal social behavior (HP:0012433)3.24712729
17Impaired social interactions (HP:0000735)3.24712729
18Abnormality of the lower motor neuron (HP:0002366)3.20089730
19Supranuclear gaze palsy (HP:0000605)3.17833285
20Dysdiadochokinesis (HP:0002075)3.16864409
21Hyperventilation (HP:0002883)3.16161935
22Depression (HP:0000716)3.13971151
23Papilledema (HP:0001085)3.13654055
24Ankle clonus (HP:0011448)3.04500680
25Gaze-evoked nystagmus (HP:0000640)2.98353040
26Urinary bladder sphincter dysfunction (HP:0002839)2.93784329
27Amblyopia (HP:0000646)2.93774558
28Chronic bronchitis (HP:0004469)2.91632243
29Dysmetria (HP:0001310)2.87889426
30Genetic anticipation (HP:0003743)2.81982887
31Anxiety (HP:0000739)2.81670799
32Megalencephaly (HP:0001355)2.78921816
33Truncal ataxia (HP:0002078)2.78909367
34Postural instability (HP:0002172)2.78409693
35Partial duplication of thumb phalanx (HP:0009944)2.78236453
36Drooling (HP:0002307)2.77872876
37Excessive salivation (HP:0003781)2.77872876
38Cerebral inclusion bodies (HP:0100314)2.76744503
39Mutism (HP:0002300)2.71952832
40Annular pancreas (HP:0001734)2.68938151
41Stereotypic behavior (HP:0000733)2.68872511
42Torticollis (HP:0000473)2.66299865
43Abnormal eating behavior (HP:0100738)2.65479337
44Impaired smooth pursuit (HP:0007772)2.63372634
45Urinary urgency (HP:0000012)2.57028360
46Ankyloglossia (HP:0010296)2.54461741
47Hepatoblastoma (HP:0002884)2.54205029
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.52589582
49Focal dystonia (HP:0004373)2.51402888
50Intention tremor (HP:0002080)2.50898565
51Hyperactive renin-angiotensin system (HP:0000841)2.50590395
52Hemiparesis (HP:0001269)2.48042055
53Pointed chin (HP:0000307)2.45692889
54Epileptiform EEG discharges (HP:0011182)2.44334814
55Scanning speech (HP:0002168)2.41421057
56Neurofibrillary tangles (HP:0002185)2.40247507
57Dysmetric saccades (HP:0000641)2.40165269
58Ventricular fibrillation (HP:0001663)2.39210978
59Hemiplegia (HP:0002301)2.38090833
60Termporal pattern (HP:0011008)2.38006686
61Insidious onset (HP:0003587)2.38006686
62Partial duplication of the phalanx of hand (HP:0009999)2.35810013
63Status epilepticus (HP:0002133)2.34171263
64EEG with generalized epileptiform discharges (HP:0011198)2.33783862
65Bradykinesia (HP:0002067)2.31393649
66Insomnia (HP:0100785)2.31041590
67Impaired vibratory sensation (HP:0002495)2.26665220
68Hypsarrhythmia (HP:0002521)2.25659332
69Abnormality of ocular smooth pursuit (HP:0000617)2.25405526
70Spastic gait (HP:0002064)2.24684622
71Amyotrophic lateral sclerosis (HP:0007354)2.23791371
72Abnormality of permanent molar morphology (HP:0011071)2.20767375
73Abnormality of the dental root (HP:0006486)2.20767375
74Taurodontia (HP:0000679)2.20767375
75High anterior hairline (HP:0009890)2.18938855
76Obstructive sleep apnea (HP:0002870)2.18497994
77Diplopia (HP:0000651)2.17976373
78Abnormality of binocular vision (HP:0011514)2.17976373
79Right ventricular cardiomyopathy (HP:0011663)2.16928217
80Craniofacial dystonia (HP:0012179)2.14825529
81Coronal craniosynostosis (HP:0004440)2.13812422
82Absent speech (HP:0001344)2.12247001
83Generalized myoclonic seizures (HP:0002123)2.09671684
84Duplication of thumb phalanx (HP:0009942)2.07155910
85Septo-optic dysplasia (HP:0100842)2.03301661
86Progressive inability to walk (HP:0002505)2.02500208
87Resting tremor (HP:0002322)1.97193091
88Lower limb asymmetry (HP:0100559)1.97067266
89Cortical dysplasia (HP:0002539)1.96150901
90Abnormality of molar morphology (HP:0011070)1.94817941
91Abnormality of molar (HP:0011077)1.94817941
92Aplasia involving bones of the extremities (HP:0009825)1.93690736
93Aplasia involving bones of the upper limbs (HP:0009823)1.93690736
94Aplasia of the phalanges of the hand (HP:0009802)1.93690736
95Abnormality of the corticospinal tract (HP:0002492)1.93420829
96Pili torti (HP:0003777)1.92675773
97Osteomalacia (HP:0002749)1.92179979
98Bronchomalacia (HP:0002780)1.92140869
99Abnormal respiratory motile cilium physiology (HP:0012261)1.91532513
100Sleep apnea (HP:0010535)1.91403562
101Increased nuchal translucency (HP:0010880)1.91204281
102Abnormality of the dental pulp (HP:0006479)1.90780414
103Lower limb amyotrophy (HP:0007210)1.89348379
104Bundle branch block (HP:0011710)1.88332076
105Choanal stenosis (HP:0000452)1.87344914
106Lower limb muscle weakness (HP:0007340)1.86762488
107Cutaneous finger syndactyly (HP:0010554)1.86317387
108Cutaneous syndactyly (HP:0012725)1.85322202
109Abnormality of the labia minora (HP:0012880)1.84414372
110Abnormality of oral frenula (HP:0000190)1.84175217
111Intellectual disability, profound (HP:0002187)1.83050618
112Overriding aorta (HP:0002623)1.82479238
113Rhinitis (HP:0012384)1.82298229
114Incomplete penetrance (HP:0003829)1.80767193
115Fetal akinesia sequence (HP:0001989)1.80626587
116Abnormality of salivation (HP:0100755)1.80458888
117Gait ataxia (HP:0002066)1.80347946
118Agitation (HP:0000713)1.78168293
119Abnormal ciliary motility (HP:0012262)1.76231161
120Inappropriate behavior (HP:0000719)1.74657785
121Abnormality of the phalanges of the hallux (HP:0010057)1.74656925
122Apathy (HP:0000741)1.73558976
123Aqueductal stenosis (HP:0002410)1.73373783
124Midline defect of the nose (HP:0004122)1.72672865
125Abnormal respiratory motile cilium morphology (HP:0005938)1.72649761
126Abnormal respiratory epithelium morphology (HP:0012253)1.72649761
127Clonus (HP:0002169)1.71696116
128Inability to walk (HP:0002540)1.70697768
129Truncus arteriosus (HP:0001660)1.70677304
130Abnormality of the distal phalanx of the thumb (HP:0009617)1.70577848
131Blue irides (HP:0000635)1.69421128
132Rapidly progressive (HP:0003678)1.69420419
133Lip pit (HP:0100267)1.69405831
134Abdominal situs inversus (HP:0003363)1.67761783
135Abnormality of abdominal situs (HP:0011620)1.67761783
136Hyperphosphatemia (HP:0002905)1.66493296
137Neuronal loss in central nervous system (HP:0002529)1.66327788
138Shawl scrotum (HP:0000049)1.65392844
139Abnormality of the salivary glands (HP:0010286)1.64831984
140Limb dystonia (HP:0002451)1.64057704
141Abnormality of the aortic arch (HP:0012303)1.63384239
142Autism (HP:0000717)1.62637330
143Reticulocytopenia (HP:0001896)1.62526760
144Absent/shortened dynein arms (HP:0200106)1.62184638
145Dynein arm defect of respiratory motile cilia (HP:0012255)1.62184638
146Turricephaly (HP:0000262)1.61899326
147Maternal diabetes (HP:0009800)1.58830577
148Bifid scrotum (HP:0000048)1.58719318
149Aplasia/Hypoplasia of the sternum (HP:0006714)1.57588926
150Anophthalmia (HP:0000528)1.55640896
151Hyperacusis (HP:0010780)1.54219430
152Absent septum pellucidum (HP:0001331)1.52548391
153Abnormality of the middle phalanges of the toes (HP:0010183)1.52334468
154Abnormality of the lacrimal duct (HP:0011481)1.51927154
155Flat acetabular roof (HP:0003180)1.51819014
156Omphalocele (HP:0001539)1.51268330
157Hyperaldosteronism (HP:0000859)1.50428366
158Facial cleft (HP:0002006)1.49795583
159Preaxial foot polydactyly (HP:0001841)1.49471576
160Spinal cord compression (HP:0002176)1.47435453
161Abnormality of renin-angiotensin system (HP:0000847)1.44809659
162Hypercalciuria (HP:0002150)1.44482300
163Shallow orbits (HP:0000586)1.44339288
164Absent radius (HP:0003974)1.43773732
165Labial hypoplasia (HP:0000066)1.43520974
166Abnormality of the septum pellucidum (HP:0007375)1.43313120
167Hypoplastic female external genitalia (HP:0012815)1.41860503
168Missing ribs (HP:0000921)1.39505882
169Hypoplastic labia majora (HP:0000059)1.38748816
170Obsessive-compulsive behavior (HP:0000722)1.38272398
171Absent eyebrow (HP:0002223)1.37547885
172Macroorchidism (HP:0000053)1.37442592
173Atresia of the external auditory canal (HP:0000413)1.36630093
174Abnormal number of incisors (HP:0011064)1.36435578
175Abnormality of cochlea (HP:0000375)1.35310672
176Bilateral microphthalmos (HP:0007633)1.35061747
177Myelomeningocele (HP:0002475)1.34667239
178Germ cell neoplasia (HP:0100728)1.33875647

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.96248914
2NTRK34.53824301
3MAP3K94.13935275
4MARK12.98854968
5DAPK22.83420749
6EPHA22.81741071
7MAP3K42.79580527
8MINK12.59268040
9KSR22.52891389
10PRKD32.44029375
11MST1R2.22776422
12PAK62.16651564
13KSR12.08567938
14MAP2K72.07700329
15STK392.04039335
16EEF2K1.99725029
17RIPK41.98199060
18CAMKK11.95748300
19MAP2K41.91360959
20NTRK21.87310940
21TTK1.84501710
22MAP3K21.64844041
23NTRK11.63406809
24CAMK1D1.63259471
25MAP3K121.61681066
26DAPK11.60763427
27CDK51.52734948
28STK381.45753213
29MET1.45359347
30PLK21.43392198
31EPHB21.39682440
32ARAF1.34944272
33SIK21.33221422
34PRPF4B1.32666651
35MAP3K101.29830041
36TYRO31.28918686
37CDC71.28548742
38LATS21.26679200
39MAP3K131.22906008
40WNK41.22258161
41PNCK1.16372088
42TSSK61.15827050
43TAOK11.13252812
44PRKCG1.11628009
45SMG11.10787696
46CASK1.10335184
47STK241.10138580
48GRK51.08645855
49SRPK11.07947950
50CDK191.05223781
51STK38L1.00450509
52BRSK10.99118384
53RAF10.98073816
54RET0.97621240
55LATS10.97506451
56TNIK0.96510252
57MAPK130.94733561
58STK110.94223718
59ICK0.93363248
60DYRK20.89857790
61CAMK10.88972046
62FES0.88800708
63CAMK2A0.88553114
64UHMK10.88548181
65ALK0.86467207
66CDK180.85815778
67CDK150.84988348
68LMTK20.84247836
69PAK30.83954622
70NEK60.82256298
71CDK140.80478617
72PTK2B0.80421607
73PRKCH0.79222131
74CAMK2B0.75463922
75MAP3K10.74781711
76CAMKK20.73834583
77SGK2230.73418109
78SGK4940.73418109
79CDK11A0.73111168
80PDK10.72742526
81NEK20.71938406
82RPS6KB20.70930047
83RIPK10.70433794
84SGK10.70393008
85FER0.69660206
86PBK0.68591370
87TAF10.68357489
88PDPK10.67926050
89CDK120.67514197
90SGK30.66834034
91PTK20.66003427
92PHKG20.64696790
93PHKG10.64696790
94MAP3K70.64685010
95SGK20.64333474
96MAPK150.63898940
97BMPR20.63194372
98DDR20.61830783
99DYRK1A0.60569160
100PRKCI0.60532221
101PLK30.60295010
102MARK20.60004882
103WNK10.59491332
104MAP2K10.59296332
105FGFR20.58588031
106CSNK1G20.58166257
107PLK10.56498329
108FGFR10.56434368
109WNK30.54913981
110WEE10.54319473
111BUB10.54156756
112PRKCZ0.52355644
113BRSK20.51401578
114NME10.51183538
115NEK10.51012286
116PIK3CA0.50990547
117SCYL20.50981388
118AURKA0.50896670
119MTOR0.49953927
120RPS6KA30.49170489
121PDGFRA0.48776278
122ERBB20.48666245
123BMX0.48298282
124OXSR10.47584044
125BRAF0.47500270
126MKNK20.47256017
127AKT30.46830073
128FRK0.46347335
129SIK10.45763364
130FYN0.45655054
131CAMK40.44769636
132TRIB30.44634795
133DMPK0.43991761
134CDC42BPA0.42291858
135MAPK100.41469539
136CCNB10.41106396
137PINK10.41080082
138DAPK30.40380458
139PRKCE0.40230174
140CAMK1G0.39581756
141FGR0.38105057
142PKN20.35276338
143CAMK2G0.33230976
144CSNK1E0.31051962
145CAMK2D0.30909211

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.43406429
2Synaptic vesicle cycle_Homo sapiens_hsa047212.91086704
3Long-term potentiation_Homo sapiens_hsa047202.84634961
4Olfactory transduction_Homo sapiens_hsa047402.66465824
5Circadian entrainment_Homo sapiens_hsa047132.66031369
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53324161
7Glutamatergic synapse_Homo sapiens_hsa047242.52733059
8Amphetamine addiction_Homo sapiens_hsa050312.52238703
9GABAergic synapse_Homo sapiens_hsa047272.52220148
10Morphine addiction_Homo sapiens_hsa050322.32425119
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26115852
12Salivary secretion_Homo sapiens_hsa049702.20467351
13Dopaminergic synapse_Homo sapiens_hsa047282.13440936
14Gastric acid secretion_Homo sapiens_hsa049711.97269760
15Insulin secretion_Homo sapiens_hsa049111.96682663
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.91840197
17Cholinergic synapse_Homo sapiens_hsa047251.87306967
18Long-term depression_Homo sapiens_hsa047301.71586847
19Renin secretion_Homo sapiens_hsa049241.69924752
20Oxytocin signaling pathway_Homo sapiens_hsa049211.66853798
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63589788
22GnRH signaling pathway_Homo sapiens_hsa049121.57999234
23Taste transduction_Homo sapiens_hsa047421.57177881
24Nitrogen metabolism_Homo sapiens_hsa009101.57024751
25Cocaine addiction_Homo sapiens_hsa050301.56776226
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.55459689
27Calcium signaling pathway_Homo sapiens_hsa040201.52869593
28* Hippo signaling pathway_Homo sapiens_hsa043901.50690220
29Basal cell carcinoma_Homo sapiens_hsa052171.48612307
30Serotonergic synapse_Homo sapiens_hsa047261.44879903
31Gap junction_Homo sapiens_hsa045401.41912202
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.41072841
33Adherens junction_Homo sapiens_hsa045201.39944457
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33126681
35Glioma_Homo sapiens_hsa052141.32166973
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28264473
37Hedgehog signaling pathway_Homo sapiens_hsa043401.25534257
38Estrogen signaling pathway_Homo sapiens_hsa049151.24931329
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24058807
40cAMP signaling pathway_Homo sapiens_hsa040241.23895252
41Type II diabetes mellitus_Homo sapiens_hsa049301.23659059
42Phenylalanine metabolism_Homo sapiens_hsa003601.22668364
43Vitamin B6 metabolism_Homo sapiens_hsa007501.20455893
44Melanogenesis_Homo sapiens_hsa049161.20324592
45Histidine metabolism_Homo sapiens_hsa003401.16840518
46Axon guidance_Homo sapiens_hsa043601.15135218
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14177134
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13311975
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12002668
50Ribosome_Homo sapiens_hsa030101.08990430
51ErbB signaling pathway_Homo sapiens_hsa040121.07035697
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06762732
53mRNA surveillance pathway_Homo sapiens_hsa030151.03187351
54Collecting duct acid secretion_Homo sapiens_hsa049661.02482166
55Arginine and proline metabolism_Homo sapiens_hsa003301.00434892
56Oocyte meiosis_Homo sapiens_hsa041140.95752355
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95565644
58Thyroid hormone synthesis_Homo sapiens_hsa049180.93045855
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.92677921
60Dorso-ventral axis formation_Homo sapiens_hsa043200.89858510
61Pancreatic secretion_Homo sapiens_hsa049720.89151704
62Thyroid cancer_Homo sapiens_hsa052160.89054164
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87188418
64Notch signaling pathway_Homo sapiens_hsa043300.85955617
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.83520253
66VEGF signaling pathway_Homo sapiens_hsa043700.80942252
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80666928
68Cell cycle_Homo sapiens_hsa041100.79737954
69Bile secretion_Homo sapiens_hsa049760.77896112
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77831048
71Choline metabolism in cancer_Homo sapiens_hsa052310.76508923
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76508610
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76311095
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75953477
75mTOR signaling pathway_Homo sapiens_hsa041500.73468531
76Vibrio cholerae infection_Homo sapiens_hsa051100.73019839
77beta-Alanine metabolism_Homo sapiens_hsa004100.70559301
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69512750
79Glucagon signaling pathway_Homo sapiens_hsa049220.67795493
80Dilated cardiomyopathy_Homo sapiens_hsa054140.67420614
81AMPK signaling pathway_Homo sapiens_hsa041520.66829529
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.65282007
83MAPK signaling pathway_Homo sapiens_hsa040100.64807896
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64805836
85Biosynthesis of amino acids_Homo sapiens_hsa012300.64276816
86Rap1 signaling pathway_Homo sapiens_hsa040150.64168183
87Protein digestion and absorption_Homo sapiens_hsa049740.63958095
88RNA transport_Homo sapiens_hsa030130.63545770
89Endometrial cancer_Homo sapiens_hsa052130.63415274
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62573102
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61082136
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61031545
93Cardiac muscle contraction_Homo sapiens_hsa042600.60874536
94Non-small cell lung cancer_Homo sapiens_hsa052230.59479302
95Mismatch repair_Homo sapiens_hsa034300.58209997
96DNA replication_Homo sapiens_hsa030300.57310354
97Phototransduction_Homo sapiens_hsa047440.57238145
98Fatty acid biosynthesis_Homo sapiens_hsa000610.57165348
99Ras signaling pathway_Homo sapiens_hsa040140.56652786
100Fat digestion and absorption_Homo sapiens_hsa049750.56487720
101Lysine degradation_Homo sapiens_hsa003100.56453915
102Huntingtons disease_Homo sapiens_hsa050160.56163406
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53724150
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.53539793
105Wnt signaling pathway_Homo sapiens_hsa043100.53194996
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52481885
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51757708
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51379487
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50989484
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50931813
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50556429
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.48791582
113Tyrosine metabolism_Homo sapiens_hsa003500.48239255
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47905445
115Inositol phosphate metabolism_Homo sapiens_hsa005620.46360284
116Base excision repair_Homo sapiens_hsa034100.46204728
117Prion diseases_Homo sapiens_hsa050200.45713471
118Alcoholism_Homo sapiens_hsa050340.45593838
119Insulin signaling pathway_Homo sapiens_hsa049100.44802321
120Renal cell carcinoma_Homo sapiens_hsa052110.44673986
121Arginine biosynthesis_Homo sapiens_hsa002200.44325233
122Endocytosis_Homo sapiens_hsa041440.43207492
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42506566
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37743589
125Circadian rhythm_Homo sapiens_hsa047100.36505693
126Tight junction_Homo sapiens_hsa045300.36126319
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34411618
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.32020604
129Mineral absorption_Homo sapiens_hsa049780.31617307
130Ovarian steroidogenesis_Homo sapiens_hsa049130.31314654
131Type I diabetes mellitus_Homo sapiens_hsa049400.31008988
132African trypanosomiasis_Homo sapiens_hsa051430.29663068
133Colorectal cancer_Homo sapiens_hsa052100.26887114
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24642720
135Prolactin signaling pathway_Homo sapiens_hsa049170.24445167

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