DLGAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a membrane-associated protein that may play a role in synapse organization and signalling in neuronal cells. This gene is biallelically expressed in the brain, however, only the paternal allele is expressed in the testis (PMID:18055845). Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.01946472
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.00530793
3vocalization behavior (GO:0071625)5.74202899
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.60415739
5synaptic vesicle exocytosis (GO:0016079)5.55843595
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.37556002
7ionotropic glutamate receptor signaling pathway (GO:0035235)5.26282561
8protein localization to synapse (GO:0035418)5.21078840
9regulation of glutamate receptor signaling pathway (GO:1900449)5.20369368
10glutamate secretion (GO:0014047)5.19832497
11neurotransmitter-gated ion channel clustering (GO:0072578)5.16745404
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.08347682
13locomotory exploration behavior (GO:0035641)5.03846566
14synaptic vesicle maturation (GO:0016188)4.99353037
15regulation of synaptic vesicle exocytosis (GO:2000300)4.89520332
16synaptic transmission, glutamatergic (GO:0035249)4.85351800
17neuron cell-cell adhesion (GO:0007158)4.84731680
18glutamate receptor signaling pathway (GO:0007215)4.81326838
19L-amino acid import (GO:0043092)4.77624773
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.66520187
21neuronal action potential propagation (GO:0019227)4.59312280
22* neuron-neuron synaptic transmission (GO:0007270)4.59303062
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.41164474
24regulation of synaptic vesicle transport (GO:1902803)4.40964993
25regulation of neuronal synaptic plasticity (GO:0048168)4.38945504
26neurotransmitter secretion (GO:0007269)4.32498662
27regulation of excitatory postsynaptic membrane potential (GO:0060079)4.26632308
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.26107666
29presynaptic membrane assembly (GO:0097105)4.16055276
30positive regulation of synapse maturation (GO:0090129)4.15886475
31negative regulation of synaptic transmission, GABAergic (GO:0032229)4.11197129
32long-term synaptic potentiation (GO:0060291)4.10385209
33positive regulation of dendritic spine development (GO:0060999)4.09961488
34long-term memory (GO:0007616)4.09667993
35positive regulation of membrane potential (GO:0045838)4.07836503
36exploration behavior (GO:0035640)4.05305589
37regulation of postsynaptic membrane potential (GO:0060078)4.03892803
38regulation of voltage-gated calcium channel activity (GO:1901385)4.03490864
39amino acid import (GO:0043090)4.02518029
40gamma-aminobutyric acid signaling pathway (GO:0007214)4.02165981
41positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.98387037
42regulation of synapse structural plasticity (GO:0051823)3.94543404
43regulation of synaptic transmission, glutamatergic (GO:0051966)3.93116606
44regulation of synaptic plasticity (GO:0048167)3.91318784
45sodium ion export (GO:0071436)3.88554685
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.85071798
47G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.83162483
48presynaptic membrane organization (GO:0097090)3.82355451
49positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.82261044
50gamma-aminobutyric acid transport (GO:0015812)3.81499174
51postsynaptic membrane organization (GO:0001941)3.80773635
52regulation of dendritic spine morphogenesis (GO:0061001)3.76548235
53behavioral fear response (GO:0001662)3.74608529
54behavioral defense response (GO:0002209)3.74608529
55negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.71325284
56behavioral response to cocaine (GO:0048148)3.63266704
57neuron recognition (GO:0008038)3.63122331
58positive regulation of neurotransmitter transport (GO:0051590)3.62784868
59positive regulation of neurotransmitter secretion (GO:0001956)3.61955886
60response to histamine (GO:0034776)3.60562060
61cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.60454652
62neuronal ion channel clustering (GO:0045161)3.57162412
63striatum development (GO:0021756)3.55043099
64transmission of nerve impulse (GO:0019226)3.53005555
65regulation of neurotransmitter secretion (GO:0046928)3.51764198
66neuromuscular synaptic transmission (GO:0007274)3.50191654
67dendritic spine morphogenesis (GO:0060997)3.49131742
68G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.48308706
69regulation of glutamate secretion (GO:0014048)3.48000025
70primary amino compound metabolic process (GO:1901160)3.47767389
71synaptic vesicle endocytosis (GO:0048488)3.47525930
72fear response (GO:0042596)3.47208789
73central nervous system myelination (GO:0022010)3.45431468
74axon ensheathment in central nervous system (GO:0032291)3.45431468
75neurotransmitter transport (GO:0006836)3.43523631
76membrane depolarization (GO:0051899)3.39848213
77regulation of synapse maturation (GO:0090128)3.39277742
78learning (GO:0007612)3.34986520
79startle response (GO:0001964)3.33501667
80regulation of neurotransmitter transport (GO:0051588)3.32932412
81positive regulation of synaptic transmission, GABAergic (GO:0032230)3.32127968
82positive regulation of synaptic transmission (GO:0050806)3.30170538
83membrane depolarization during action potential (GO:0086010)3.29013215
84phosphorelay signal transduction system (GO:0000160)3.27203852
85regulation of dendritic spine development (GO:0060998)3.25780482
86neuronal action potential (GO:0019228)3.24326025
87proline transport (GO:0015824)3.24243171
88cerebellar Purkinje cell differentiation (GO:0021702)3.23815408
89axonal fasciculation (GO:0007413)3.22606377
90membrane hyperpolarization (GO:0060081)3.22466671
91negative regulation of dendrite morphogenesis (GO:0050774)3.22304729
92long term synaptic depression (GO:0060292)3.22265025
93regulation of neurotransmitter levels (GO:0001505)3.20904860
94layer formation in cerebral cortex (GO:0021819)3.20248748
95regulation of vesicle fusion (GO:0031338)3.19114480
96adult walking behavior (GO:0007628)3.18600396
97negative regulation of amino acid transport (GO:0051956)3.18561968
98regulation of synaptic transmission (GO:0050804)3.18535866
99* synaptic transmission (GO:0007268)3.18371096
100calcium ion-dependent exocytosis (GO:0017156)3.18102951
101regulation of female receptivity (GO:0045924)3.16022392
102cerebellar granule cell differentiation (GO:0021707)3.15390419
103potassium ion import (GO:0010107)3.14881513
104acidic amino acid transport (GO:0015800)3.12074180
105cellular potassium ion homeostasis (GO:0030007)3.11227965
106auditory behavior (GO:0031223)3.10737005
107cell communication by electrical coupling (GO:0010644)3.10611538
108response to auditory stimulus (GO:0010996)3.10122552
109prepulse inhibition (GO:0060134)3.09672088
110detection of calcium ion (GO:0005513)3.09404334
111positive regulation of dendritic spine morphogenesis (GO:0061003)3.07744146
112neurotransmitter uptake (GO:0001504)3.06573080
113social behavior (GO:0035176)3.06557312
114intraspecies interaction between organisms (GO:0051703)3.06557312
115potassium ion homeostasis (GO:0055075)3.05895348
116neuromuscular process controlling posture (GO:0050884)3.04869625
117neuromuscular process controlling balance (GO:0050885)3.02527376
118mechanosensory behavior (GO:0007638)3.02411455
119regulation of synaptic transmission, GABAergic (GO:0032228)3.02039406
120activation of protein kinase A activity (GO:0034199)3.00409245
121regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99294928
122regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.99077175
123synaptic transmission, dopaminergic (GO:0001963)2.98788340
124female mating behavior (GO:0060180)2.98578696
125negative regulation of dendrite development (GO:2000171)2.98375869
126synapse assembly (GO:0007416)2.96920324
127serotonin metabolic process (GO:0042428)2.96174157

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.31956817
2GBX2_23144817_ChIP-Seq_PC3_Human4.50902754
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14981630
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02954514
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97287639
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.66707575
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.63895483
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62882035
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57876312
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57876312
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54864879
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46470972
13* EZH2_27304074_Chip-Seq_ESCs_Mouse2.46228836
14DROSHA_22980978_ChIP-Seq_HELA_Human2.44733678
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39976296
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38464787
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37352081
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.28800130
19TAF15_26573619_Chip-Seq_HEK293_Human2.23160462
20* REST_18959480_ChIP-ChIP_MESCs_Mouse2.14982412
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14705314
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09770876
23* RNF2_27304074_Chip-Seq_ESCs_Mouse2.08354600
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.08195764
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08007368
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97570252
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97188236
28* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.95852024
29AR_21572438_ChIP-Seq_LNCaP_Human1.89776848
30SMAD4_21799915_ChIP-Seq_A2780_Human1.87201335
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86449187
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85023076
33* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82214802
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79668499
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75739369
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75051212
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63836264
38* P300_19829295_ChIP-Seq_ESCs_Human1.63428716
39* SMAD3_21741376_ChIP-Seq_EPCs_Human1.48506223
40* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44587962
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.42352508
42AR_25329375_ChIP-Seq_VCAP_Human1.40922738
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.38592436
44* SOX2_21211035_ChIP-Seq_LN229_Gbm1.38483665
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.36988577
46STAT3_23295773_ChIP-Seq_U87_Human1.36936676
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36922205
48FUS_26573619_Chip-Seq_HEK293_Human1.36735836
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36561199
50* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36231034
51* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35242928
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31444371
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.28791066
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28675721
55* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28050388
56* TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25578511
57* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25345957
58* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24625990
59ZNF274_21170338_ChIP-Seq_K562_Hela1.23877531
60* TCF4_23295773_ChIP-Seq_U87_Human1.23339036
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20862338
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19945883
63AR_19668381_ChIP-Seq_PC3_Human1.19893652
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.18438491
65RNF2_27304074_Chip-Seq_NSC_Mouse1.18016769
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.15624535
67VDR_22108803_ChIP-Seq_LS180_Human1.14515438
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14365516
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13918558
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13731352
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.13396641
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12712580
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12600504
74IGF1R_20145208_ChIP-Seq_DFB_Human1.12332486
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.12319497
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11410430
77* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11301472
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10894866
79AHR_22903824_ChIP-Seq_MCF-7_Human1.10667018
80JUN_21703547_ChIP-Seq_K562_Human1.06712756
81* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06667408
82* RUNX2_22187159_ChIP-Seq_PCA_Human1.05972430
83ER_23166858_ChIP-Seq_MCF-7_Human1.02725367
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.02552488
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02198305
86TP53_16413492_ChIP-PET_HCT116_Human1.02120309
87* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01476360
88* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00596363
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00239312
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00239312
91CBP_20019798_ChIP-Seq_JUKART_Human0.99632177
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99632177
93NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99582317
94BCAT_22108803_ChIP-Seq_LS180_Human0.99579428
95* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99206494
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97964747
97SMAD3_21741376_ChIP-Seq_HESCs_Human0.97579103
98KDM2B_26808549_Chip-Seq_REH_Human0.97438590
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96918106
100* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96120523
101DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95862496
102RING1B_27294783_Chip-Seq_NPCs_Mouse0.95834643
103* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93338403
104* TP53_18474530_ChIP-ChIP_U2OS_Human0.91635284
105* SMAD3_21741376_ChIP-Seq_ESCs_Human0.89995140
106CTCF_27219007_Chip-Seq_Bcells_Human0.89861899
107SMAD4_21741376_ChIP-Seq_HESCs_Human0.89843261
108E2F1_18555785_Chip-Seq_ESCs_Mouse0.89448822
109SOX9_26525672_Chip-Seq_HEART_Mouse0.89421112
110SMAD4_21741376_ChIP-Seq_EPCs_Human0.89052880
111* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88640131
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88176908

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.74696254
2MP0003880_abnormal_central_pattern5.48235212
3MP0003635_abnormal_synaptic_transmissio4.26517008
4MP0009745_abnormal_behavioral_response3.74376315
5MP0002822_catalepsy3.70484443
6MP0002063_abnormal_learning/memory/cond3.55809798
7MP0004270_analgesia3.48921650
8MP0002064_seizures3.37234688
9MP0009046_muscle_twitch3.26246142
10MP0001968_abnormal_touch/_nociception3.13777833
11MP0002572_abnormal_emotion/affect_behav3.04447597
12MP0002272_abnormal_nervous_system2.74562509
13MP0001486_abnormal_startle_reflex2.65955260
14MP0002736_abnormal_nociception_after2.57710531
15MP0001501_abnormal_sleep_pattern2.48299365
16MP0002734_abnormal_mechanical_nocicepti2.38777755
17MP0002735_abnormal_chemical_nociception2.33108900
18MP0005423_abnormal_somatic_nervous2.21027598
19MP0001440_abnormal_grooming_behavior2.11370590
20MP0003787_abnormal_imprinting2.04553971
21MP0005646_abnormal_pituitary_gland2.03278111
22MP0003879_abnormal_hair_cell2.01385518
23MP0002067_abnormal_sensory_capabilities2.00232626
24MP0009780_abnormal_chondrocyte_physiolo1.99181772
25MP0001970_abnormal_pain_threshold1.81518565
26MP0001529_abnormal_vocalization1.74856946
27MP0002733_abnormal_thermal_nociception1.74302007
28MP0008569_lethality_at_weaning1.73467058
29MP0002557_abnormal_social/conspecific_i1.72339163
30MP0001984_abnormal_olfaction1.68977397
31MP0004924_abnormal_behavior1.66572565
32MP0005386_behavior/neurological_phenoty1.66572565
33MP0004811_abnormal_neuron_physiology1.63821596
34MP0002184_abnormal_innervation1.61727319
35MP0001188_hyperpigmentation1.59883407
36MP0000778_abnormal_nervous_system1.56463080
37MP0003329_amyloid_beta_deposits1.37202636
38MP0002066_abnormal_motor_capabilities/c1.36613727
39MP0000955_abnormal_spinal_cord1.35686357
40MP0002909_abnormal_adrenal_gland1.34344377
41MP0002882_abnormal_neuron_morphology1.32315588
42MP0004858_abnormal_nervous_system1.31586041
43MP0004142_abnormal_muscle_tone1.31232121
44MP0001905_abnormal_dopamine_level1.30668299
45MP0006276_abnormal_autonomic_nervous1.27096185
46MP0003633_abnormal_nervous_system1.25546223
47MP0002876_abnormal_thyroid_physiology1.23601046
48MP0002638_abnormal_pupillary_reflex1.16686768
49MP0003122_maternal_imprinting1.15485711
50MP0005410_abnormal_fertilization1.14033132
51MP0001502_abnormal_circadian_rhythm1.12538105
52MP0008872_abnormal_physiological_respon1.12451509
53MP0005645_abnormal_hypothalamus_physiol1.11367936
54MP0003631_nervous_system_phenotype1.05978277
55MP0004885_abnormal_endolymph1.03262126
56MP0002152_abnormal_brain_morphology1.00023668
57MP0008874_decreased_physiological_sensi0.99334156
58MP0002837_dystrophic_cardiac_calcinosis0.98409433
59MP0001986_abnormal_taste_sensitivity0.97639484
60MP0002069_abnormal_eating/drinking_beha0.97520080
61MP0010386_abnormal_urinary_bladder0.93514931
62MP0008877_abnormal_DNA_methylation0.92589573
63MP0004147_increased_porphyrin_level0.92113681
64MP0000751_myopathy0.91372309
65MP0005551_abnormal_eye_electrophysiolog0.91134896
66MP0005187_abnormal_penis_morphology0.89622377
67MP0004085_abnormal_heartbeat0.89193808
68MP0001177_atelectasis0.88847699
69MP0001963_abnormal_hearing_physiology0.87795096
70MP0004145_abnormal_muscle_electrophysio0.87467327
71MP0003123_paternal_imprinting0.86033870
72MP0005409_darkened_coat_color0.85836941
73MP0002229_neurodegeneration0.84123491
74MP0005394_taste/olfaction_phenotype0.79681486
75MP0005499_abnormal_olfactory_system0.79681486
76MP0004215_abnormal_myocardial_fiber0.78027827
77MP0005171_absent_coat_pigmentation0.77295794
78MP0004742_abnormal_vestibular_system0.76670876
79MP0000013_abnormal_adipose_tissue0.76436078
80MP0001485_abnormal_pinna_reflex0.76321186
81MP0003121_genomic_imprinting0.73553233
82MP0003698_abnormal_male_reproductive0.72732400
83MP0003075_altered_response_to0.71962654
84MP0004484_altered_response_of0.70682729
85MP0008961_abnormal_basal_metabolism0.69648209
86MP0006292_abnormal_olfactory_placode0.68638391
87MP0001664_abnormal_digestion0.68228755
88MP0005535_abnormal_body_temperature0.67877261
89MP0002752_abnormal_somatic_nervous0.67537353
90MP0003632_abnormal_nervous_system0.66707627
91MP0005253_abnormal_eye_physiology0.65638330
92MP0000631_abnormal_neuroendocrine_gland0.65624130
93MP0003646_muscle_fatigue0.65422404
94MP0004233_abnormal_muscle_weight0.64101854
95MP0005167_abnormal_blood-brain_barrier0.63970901
96MP0000569_abnormal_digit_pigmentation0.62592162
97MP0003861_abnormal_nervous_system0.59193985
98MP0006072_abnormal_retinal_apoptosis0.58924352
99MP0001348_abnormal_lacrimal_gland0.58710772
100MP0003183_abnormal_peptide_metabolism0.58412170
101MP0003315_abnormal_perineum_morphology0.57166650
102MP0002090_abnormal_vision0.56606118
103MP0000026_abnormal_inner_ear0.54064863
104MP0001346_abnormal_lacrimal_gland0.53842156
105MP0003634_abnormal_glial_cell0.53357742
106MP0003690_abnormal_glial_cell0.52819457
107MP0002138_abnormal_hepatobiliary_system0.52578964
108MP0004130_abnormal_muscle_cell0.52490476
109MP0003137_abnormal_impulse_conducting0.52105579
110MP0001943_abnormal_respiration0.52088948
111MP0000604_amyloidosis0.51943250
112MP0010769_abnormal_survival0.51507421
113MP0002082_postnatal_lethality0.51154903
114MP0010770_preweaning_lethality0.51154903
115MP0004043_abnormal_pH_regulation0.50987549
116MP0004510_myositis0.49645311
117MP0000920_abnormal_myelination0.49066695

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.73193573
2Myokymia (HP:0002411)7.04307257
3Focal seizures (HP:0007359)6.35130884
4Epileptic encephalopathy (HP:0200134)5.97550294
5Febrile seizures (HP:0002373)5.60945726
6Atonic seizures (HP:0010819)5.59542680
7Hyperventilation (HP:0002883)4.88618832
8Absence seizures (HP:0002121)4.72927477
9Visual hallucinations (HP:0002367)4.56717523
10Progressive cerebellar ataxia (HP:0002073)4.53772033
11Dialeptic seizures (HP:0011146)4.48895967
12Generalized tonic-clonic seizures (HP:0002069)4.27266260
13Broad-based gait (HP:0002136)4.05142021
14Gaze-evoked nystagmus (HP:0000640)3.92058761
15Poor eye contact (HP:0000817)3.57523639
16Impaired vibration sensation in the lower limbs (HP:0002166)3.41507556
17Dysdiadochokinesis (HP:0002075)3.36232113
18Amblyopia (HP:0000646)3.34055958
19Action tremor (HP:0002345)3.21224424
20Abnormal social behavior (HP:0012433)3.19159926
21Impaired social interactions (HP:0000735)3.19159926
22Cerebral hypomyelination (HP:0006808)3.08741836
23Abnormal eating behavior (HP:0100738)3.08134829
24Dysmetria (HP:0001310)3.05582845
25Epileptiform EEG discharges (HP:0011182)3.02981375
26Truncal ataxia (HP:0002078)2.94055159
27Urinary bladder sphincter dysfunction (HP:0002839)2.93272125
28Anxiety (HP:0000739)2.87449208
29Excessive salivation (HP:0003781)2.84762664
30Drooling (HP:0002307)2.84762664
31Depression (HP:0000716)2.83380033
32Genetic anticipation (HP:0003743)2.81273089
33Papilledema (HP:0001085)2.79092996
34Impaired smooth pursuit (HP:0007772)2.76392126
35Scanning speech (HP:0002168)2.74047399
36Dysmetric saccades (HP:0000641)2.71086764
37EEG with generalized epileptiform discharges (HP:0011198)2.70077957
38Absent speech (HP:0001344)2.66090150
39Stereotypic behavior (HP:0000733)2.65591772
40Postural instability (HP:0002172)2.59210969
41Aplasia involving bones of the extremities (HP:0009825)2.58067894
42Aplasia involving bones of the upper limbs (HP:0009823)2.58067894
43Aplasia of the phalanges of the hand (HP:0009802)2.58067894
44Ankle clonus (HP:0011448)2.57327377
45Protruding tongue (HP:0010808)2.56511395
46Abnormality of the lower motor neuron (HP:0002366)2.54108437
47Inability to walk (HP:0002540)2.50347981
48Torticollis (HP:0000473)2.47403863
49Akinesia (HP:0002304)2.46948178
50Hypsarrhythmia (HP:0002521)2.46127490
51Focal dystonia (HP:0004373)2.44648637
52Progressive inability to walk (HP:0002505)2.43813854
53Clonus (HP:0002169)2.42753291
54Impaired vibratory sensation (HP:0002495)2.41125827
55Abnormality of binocular vision (HP:0011514)2.39176561
56Diplopia (HP:0000651)2.39176561
57Polyphagia (HP:0002591)2.38729224
58Status epilepticus (HP:0002133)2.36874346
59Neurofibrillary tangles (HP:0002185)2.36349664
60Bradykinesia (HP:0002067)2.34863510
61Abnormality of ocular smooth pursuit (HP:0000617)2.30967134
62Fetal akinesia sequence (HP:0001989)2.28020995
63Supranuclear gaze palsy (HP:0000605)2.27734277
64Annular pancreas (HP:0001734)2.26244663
65Urinary urgency (HP:0000012)2.24637168
66Delayed CNS myelination (HP:0002188)2.24019442
67Hemiparesis (HP:0001269)2.22472558
68Spastic gait (HP:0002064)2.21682076
69Blue irides (HP:0000635)2.20841205
70Abnormal hair whorl (HP:0010721)2.18050987
71Gait imbalance (HP:0002141)2.17588201
72Generalized myoclonic seizures (HP:0002123)2.15126154
73Incomplete penetrance (HP:0003829)2.14303578
74Craniofacial dystonia (HP:0012179)2.10924321
75Hemiplegia (HP:0002301)2.09127155
76Mutism (HP:0002300)2.08629357
77Termporal pattern (HP:0011008)2.08596281
78Insidious onset (HP:0003587)2.08596281
79Syncope (HP:0001279)2.08443242
80Tetraplegia (HP:0002445)2.07720731
81Resting tremor (HP:0002322)2.05140015
82CNS hypomyelination (HP:0003429)2.04430080
83Peripheral hypomyelination (HP:0007182)2.00083503
84Pheochromocytoma (HP:0002666)1.97172327
85Morphological abnormality of the pyramidal tract (HP:0002062)1.95588974
86Specific learning disability (HP:0001328)1.94380431
87Type II lissencephaly (HP:0007260)1.94310461
88Abnormality of salivation (HP:0100755)1.93710553
89Congenital primary aphakia (HP:0007707)1.92736376
90Gait ataxia (HP:0002066)1.90737448
91Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89731852
92Degeneration of the lateral corticospinal tracts (HP:0002314)1.89731852
93Medial flaring of the eyebrow (HP:0010747)1.89567661
94Prolonged QT interval (HP:0001657)1.87074444
95Lower limb amyotrophy (HP:0007210)1.86802889
96Generalized hypopigmentation of hair (HP:0011358)1.86535782
97Bundle branch block (HP:0011710)1.85638380
98Ventricular fibrillation (HP:0001663)1.85251012
99Optic nerve hypoplasia (HP:0000609)1.85231200
100Thickened helices (HP:0000391)1.83714173
101Abnormality of the phalanges of the 2nd finger (HP:0009541)1.83555074
102Nephrogenic diabetes insipidus (HP:0009806)1.82280175
103Retinal dysplasia (HP:0007973)1.81812143
104Spastic tetraplegia (HP:0002510)1.79511572
105Choreoathetosis (HP:0001266)1.78592460
106Neuronal loss in central nervous system (HP:0002529)1.78376565
107Deeply set eye (HP:0000490)1.78265042
108Intention tremor (HP:0002080)1.78210918
109Hypoventilation (HP:0002791)1.77434270
110Abnormality of the periventricular white matter (HP:0002518)1.77351058
111Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77345411
112Spastic tetraparesis (HP:0001285)1.77243681
113Lower limb muscle weakness (HP:0007340)1.76899854
114Rigidity (HP:0002063)1.76075616
115Unsteady gait (HP:0002317)1.75220247
116Apathy (HP:0000741)1.73286750
117Failure to thrive in infancy (HP:0001531)1.72956838
118Gastroesophageal reflux (HP:0002020)1.72113213
119Abnormality of saccadic eye movements (HP:0000570)1.71431782
120Widely spaced teeth (HP:0000687)1.71153277
121Abnormality of the corticospinal tract (HP:0002492)1.70051856
122Neuroendocrine neoplasm (HP:0100634)1.69947498
123Pointed chin (HP:0000307)1.69870288
124Abnormal EKG (HP:0003115)1.69839705
125Sleep apnea (HP:0010535)1.69679575
126Fair hair (HP:0002286)1.69677377
127Poor suck (HP:0002033)1.69535643
128Cerebral inclusion bodies (HP:0100314)1.69521495
129Limb dystonia (HP:0002451)1.68958994
130Autism (HP:0000717)1.66020853
131Delusions (HP:0000746)1.65128361

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.55222392
2NTRK34.84676418
3CASK3.70916776
4MAP3K43.15179908
5MAP3K93.02584888
6MAP2K72.95670923
7DAPK22.60251243
8MINK12.25951722
9DAPK12.16398742
10RIPK42.15483592
11TNIK2.11403995
12MAP3K122.08694480
13PRPF4B2.01762904
14MARK11.91947608
15FRK1.90511719
16PAK61.89746321
17PLK21.89335906
18KSR11.83910108
19BMPR1B1.83636406
20MAP2K41.79411614
21NTRK21.68108676
22KSR21.66863172
23CDK191.65803506
24CAMKK11.54077133
25SIK31.47879659
26CDK51.44917986
27FES1.43387153
28PRKD31.32050305
29AKT31.31952702
30PRKCG1.30712099
31MAP3K131.26427209
32ARAF1.26118567
33CCNB11.23754392
34MAPK131.22137923
35GRK51.16923913
36BMPR21.16923220
37SIK21.16351856
38CAMK2A1.14607209
39NTRK11.13538230
40CAMKK21.13086956
41SGK21.11103231
42SGK2231.08334477
43SGK4941.08334477
44STK381.05714199
45CAMK2B1.05386239
46PTK2B1.04594746
47OXSR10.98517174
48MAPK120.97756172
49CAMK10.97056607
50CDK180.89370209
51RAF10.87961380
52PKN10.87549050
53NME10.85094741
54CDK150.81056292
55FGFR20.80608595
56SGK10.78180676
57PNCK0.77402986
58SGK30.77279705
59CDK140.76089372
60MAP3K20.74769442
61TAOK10.74243494
62BRAF0.70558142
63MARK20.70323733
64WNK40.70154013
65CDK11A0.69857534
66BCR0.69565601
67MAP3K60.69236755
68UHMK10.68520140
69DYRK1A0.66991782
70STK110.64660084
71PRKCE0.64597420
72PRKCH0.60652671
73TSSK60.60056048
74CSNK1G30.59925774
75DYRK20.59019110
76TGFBR10.58066898
77ACVR1B0.57781043
78TYRO30.56714000
79CSNK1A1L0.56701168
80PDK10.54861219
81WNK10.54115492
82CAMK2D0.53781614
83CSNK1G20.52561722
84NEK60.52394966
85PRKCI0.51358797
86PINK10.50782875
87TNK20.50546043
88PDPK10.50114668
89FER0.50010582
90FGR0.49621778
91CAMK40.47833679
92MAP2K10.47593755
93INSRR0.47157944
94CAMK2G0.46879727
95ALK0.46387260
96DAPK30.45848114
97RET0.45233440
98PAK30.43384157
99WNK30.42375327
100* RPS6KA30.42194563
101KIT0.42144968
102CSNK1D0.40310518
103MAP3K10.38913347
104GRK10.38360216
105PRKCZ0.37619314
106MAP4K20.37538850
107CSNK1G10.37247410
108* PRKG10.35835194
109SYK0.35505920
110FYN0.35395205
111CDK30.34862391
112MAP3K70.33641277
113MAPK100.33098849
114MAP3K110.31642770
115PRKACA0.31156699
116DMPK0.31045737
117LATS20.30782387
118CAMK1G0.30534630
119PHKG20.30181747
120PHKG10.30181747
121* PRKCB0.29804903
122PRKCA0.29779792
123MAPK70.29357563
124* CSNK1E0.28437281
125CDC42BPA0.28015988

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.28272712
2Synaptic vesicle cycle_Homo sapiens_hsa047213.58399594
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.98786270
4Circadian entrainment_Homo sapiens_hsa047132.96061335
5Olfactory transduction_Homo sapiens_hsa047402.86663621
6Long-term potentiation_Homo sapiens_hsa047202.86621392
7GABAergic synapse_Homo sapiens_hsa047272.83315220
8Morphine addiction_Homo sapiens_hsa050322.79849060
9Glutamatergic synapse_Homo sapiens_hsa047242.74742084
10Amphetamine addiction_Homo sapiens_hsa050312.72354037
11Dopaminergic synapse_Homo sapiens_hsa047282.27397916
12Salivary secretion_Homo sapiens_hsa049702.22743541
13Collecting duct acid secretion_Homo sapiens_hsa049662.21317391
14Insulin secretion_Homo sapiens_hsa049111.94315012
15Taste transduction_Homo sapiens_hsa047421.90623335
16Cholinergic synapse_Homo sapiens_hsa047251.89625402
17Serotonergic synapse_Homo sapiens_hsa047261.82632592
18Long-term depression_Homo sapiens_hsa047301.81047228
19Renin secretion_Homo sapiens_hsa049241.81033645
20Calcium signaling pathway_Homo sapiens_hsa040201.79680384
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78981733
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77643683
23Oxytocin signaling pathway_Homo sapiens_hsa049211.73062601
24Cocaine addiction_Homo sapiens_hsa050301.71202281
25Gastric acid secretion_Homo sapiens_hsa049711.69162800
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48172717
27cAMP signaling pathway_Homo sapiens_hsa040241.35044147
28Vibrio cholerae infection_Homo sapiens_hsa051101.32228055
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31413671
30GnRH signaling pathway_Homo sapiens_hsa049121.29689984
31Gap junction_Homo sapiens_hsa045401.26219366
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22665963
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17727011
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14093890
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13493977
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10128327
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09560288
38Type II diabetes mellitus_Homo sapiens_hsa049301.08401067
39Axon guidance_Homo sapiens_hsa043601.05374203
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04677971
41ErbB signaling pathway_Homo sapiens_hsa040120.97317424
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97048537
43Estrogen signaling pathway_Homo sapiens_hsa049150.96757082
44Glioma_Homo sapiens_hsa052140.96321862
45Vitamin B6 metabolism_Homo sapiens_hsa007500.96290476
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.96115883
47Melanogenesis_Homo sapiens_hsa049160.88477156
48Phototransduction_Homo sapiens_hsa047440.88080536
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87885218
50Cardiac muscle contraction_Homo sapiens_hsa042600.83341127
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82077863
52Oocyte meiosis_Homo sapiens_hsa041140.75026912
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74695278
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74533288
55Pancreatic secretion_Homo sapiens_hsa049720.72873993
56MAPK signaling pathway_Homo sapiens_hsa040100.66802386
57Dilated cardiomyopathy_Homo sapiens_hsa054140.66766188
58Choline metabolism in cancer_Homo sapiens_hsa052310.66487424
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.65380313
60Circadian rhythm_Homo sapiens_hsa047100.61773207
61Type I diabetes mellitus_Homo sapiens_hsa049400.61490957
62Ras signaling pathway_Homo sapiens_hsa040140.58758747
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56158113
64Thyroid hormone synthesis_Homo sapiens_hsa049180.55527321
65Alzheimers disease_Homo sapiens_hsa050100.54175576
66Butanoate metabolism_Homo sapiens_hsa006500.53507908
67Glucagon signaling pathway_Homo sapiens_hsa049220.53247154
68Rap1 signaling pathway_Homo sapiens_hsa040150.51886177
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51063352
70Rheumatoid arthritis_Homo sapiens_hsa053230.49962874
71Nitrogen metabolism_Homo sapiens_hsa009100.49208064
72Oxidative phosphorylation_Homo sapiens_hsa001900.48935583
73Inositol phosphate metabolism_Homo sapiens_hsa005620.48843070
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47409049
75Dorso-ventral axis formation_Homo sapiens_hsa043200.47360737
76Alcoholism_Homo sapiens_hsa050340.45643998
77Fatty acid biosynthesis_Homo sapiens_hsa000610.45432113
78beta-Alanine metabolism_Homo sapiens_hsa004100.45221434
79VEGF signaling pathway_Homo sapiens_hsa043700.43450933
80African trypanosomiasis_Homo sapiens_hsa051430.41871012
81Histidine metabolism_Homo sapiens_hsa003400.40145101
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.39895043
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38490289
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37360278
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37152704
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36085275
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34890217
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.34462330
89Wnt signaling pathway_Homo sapiens_hsa043100.33394142
90Ovarian steroidogenesis_Homo sapiens_hsa049130.31993824
91Non-small cell lung cancer_Homo sapiens_hsa052230.31838194
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30915117
93mTOR signaling pathway_Homo sapiens_hsa041500.30497636
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30065037
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29604867
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28305984
97Endocytosis_Homo sapiens_hsa041440.28190499
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28155662
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27074678
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26092680
101Tight junction_Homo sapiens_hsa045300.25393734
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24711481
103Chemokine signaling pathway_Homo sapiens_hsa040620.24387460
104Phagosome_Homo sapiens_hsa041450.23948323
105Ether lipid metabolism_Homo sapiens_hsa005650.23447157
106Mineral absorption_Homo sapiens_hsa049780.22794214
107Hippo signaling pathway_Homo sapiens_hsa043900.22534611
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22053023
109Insulin signaling pathway_Homo sapiens_hsa049100.21963221
110Endometrial cancer_Homo sapiens_hsa052130.21219692
111Arginine biosynthesis_Homo sapiens_hsa002200.20966438
112Bile secretion_Homo sapiens_hsa049760.20830010
113Regulation of autophagy_Homo sapiens_hsa041400.20256980
114Prion diseases_Homo sapiens_hsa050200.19952960
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18626849
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.17853216
117Arginine and proline metabolism_Homo sapiens_hsa003300.17687536

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