

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle maturation (GO:0016188) | 6.89487943 |
| 2 | locomotory exploration behavior (GO:0035641) | 6.54169584 |
| 3 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 6.51142902 |
| 4 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 6.41046206 |
| 5 | vocalization behavior (GO:0071625) | 5.76740138 |
| 6 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.75726859 |
| 7 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.61666943 |
| 8 | regulation of synapse structural plasticity (GO:0051823) | 5.48425991 |
| 9 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 5.45656292 |
| 10 | synaptic vesicle exocytosis (GO:0016079) | 5.31663694 |
| 11 | regulation of glutamate receptor signaling pathway (GO:1900449) | 5.29419601 |
| 12 | glutamate secretion (GO:0014047) | 5.15788604 |
| 13 | regulation of neuronal synaptic plasticity (GO:0048168) | 5.15155606 |
| 14 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 5.15135762 |
| 15 | regulation of synaptic vesicle exocytosis (GO:2000300) | 5.12162268 |
| 16 | dendritic spine morphogenesis (GO:0060997) | 4.85408831 |
| 17 | exploration behavior (GO:0035640) | 4.77865917 |
| 18 | cerebellar granule cell differentiation (GO:0021707) | 4.73818190 |
| 19 | layer formation in cerebral cortex (GO:0021819) | 4.71770839 |
| 20 | protein localization to synapse (GO:0035418) | 4.71373524 |
| 21 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 4.60636364 |
| 22 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.59871770 |
| 23 | neurotransmitter secretion (GO:0007269) | 4.58659587 |
| 24 | regulation of synaptic vesicle transport (GO:1902803) | 4.54288233 |
| 25 | postsynaptic membrane organization (GO:0001941) | 4.53650499 |
| 26 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.50250930 |
| 27 | neuronal action potential propagation (GO:0019227) | 4.35935126 |
| 28 | regulation of dendritic spine morphogenesis (GO:0061001) | 4.33827587 |
| 29 | amino acid import (GO:0043090) | 4.32743197 |
| 30 | prepulse inhibition (GO:0060134) | 4.32040589 |
| 31 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.28628225 |
| 32 | neuromuscular process controlling balance (GO:0050885) | 4.27868373 |
| 33 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 4.27494026 |
| 34 | auditory behavior (GO:0031223) | 4.24687058 |
| 35 | positive regulation of membrane potential (GO:0045838) | 4.22938050 |
| 36 | synaptic transmission, glutamatergic (GO:0035249) | 4.19759161 |
| 37 | long-term memory (GO:0007616) | 4.15572196 |
| 38 | gamma-aminobutyric acid transport (GO:0015812) | 4.09016147 |
| 39 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 4.05469482 |
| 40 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 4.03710579 |
| 41 | regulation of synapse maturation (GO:0090128) | 4.02867578 |
| 42 | neuron-neuron synaptic transmission (GO:0007270) | 3.94655937 |
| 43 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.93147648 |
| 44 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.91972742 |
| 45 | regulation of synaptic plasticity (GO:0048167) | 3.90036946 |
| 46 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.89713243 |
| 47 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.85192247 |
| 48 | response to auditory stimulus (GO:0010996) | 3.81857212 |
| 49 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.80314286 |
| 50 | positive regulation of neurotransmitter transport (GO:0051590) | 3.79091662 |
| 51 | glutamate receptor signaling pathway (GO:0007215) | 3.78743495 |
| 52 | neuron cell-cell adhesion (GO:0007158) | 3.78247895 |
| 53 | activation of protein kinase A activity (GO:0034199) | 3.78144312 |
| 54 | regulation of postsynaptic membrane potential (GO:0060078) | 3.77223591 |
| 55 | proline transport (GO:0015824) | 3.75654398 |
| 56 | cellular potassium ion homeostasis (GO:0030007) | 3.71300533 |
| 57 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.70152196 |
| 58 | sodium ion export (GO:0071436) | 3.67074423 |
| 59 | potassium ion homeostasis (GO:0055075) | 3.64752520 |
| 60 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.64516037 |
| 61 | glycine transport (GO:0015816) | 3.63344708 |
| 62 | positive regulation of synapse maturation (GO:0090129) | 3.62133851 |
| 63 | dendritic spine organization (GO:0097061) | 3.57794472 |
| 64 | transmission of nerve impulse (GO:0019226) | 3.57681355 |
| 65 | neuronal ion channel clustering (GO:0045161) | 3.54292658 |
| 66 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.53840427 |
| 67 | neurotransmitter transport (GO:0006836) | 3.53484744 |
| 68 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.51143577 |
| 69 | regulation of neurotransmitter secretion (GO:0046928) | 3.47917306 |
| 70 | chemosensory behavior (GO:0007635) | 3.47350549 |
| 71 | central nervous system myelination (GO:0022010) | 3.46727483 |
| 72 | axon ensheathment in central nervous system (GO:0032291) | 3.46727483 |
| 73 | potassium ion import (GO:0010107) | 3.46322622 |
| 74 | regulation of dendritic spine development (GO:0060998) | 3.46112375 |
| 75 | neuromuscular synaptic transmission (GO:0007274) | 3.44963114 |
| 76 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 3.41672728 |
| 77 | positive regulation of dendritic spine development (GO:0060999) | 3.40946438 |
| 78 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 3.38543206 |
| 79 | neuromuscular process controlling posture (GO:0050884) | 3.38414953 |
| 80 | regulation of neurotransmitter levels (GO:0001505) | 3.38142541 |
| 81 | acidic amino acid transport (GO:0015800) | 3.34851573 |
| 82 | dopamine receptor signaling pathway (GO:0007212) | 3.33937513 |
| 83 | adenosine receptor signaling pathway (GO:0001973) | 3.33589497 |
| 84 | regulation of neurotransmitter transport (GO:0051588) | 3.32928302 |
| 85 | synaptic transmission, dopaminergic (GO:0001963) | 3.32064599 |
| 86 | long-term synaptic potentiation (GO:0060291) | 3.31148806 |
| 87 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.29625113 |
| 88 | regulation of ARF protein signal transduction (GO:0032012) | 3.28859176 |
| 89 | regulation of female receptivity (GO:0045924) | 3.27032742 |
| 90 | membrane hyperpolarization (GO:0060081) | 3.26301266 |
| 91 | synaptic transmission (GO:0007268) | 3.25766300 |
| 92 | striatum development (GO:0021756) | 3.24900412 |
| 93 | synaptic vesicle endocytosis (GO:0048488) | 3.24405394 |
| 94 | neuromuscular process (GO:0050905) | 3.24260759 |
| 95 | cell differentiation in hindbrain (GO:0021533) | 3.24095441 |
| 96 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.21623448 |
| 97 | cell migration in hindbrain (GO:0021535) | 3.20770876 |
| 98 | membrane depolarization (GO:0051899) | 3.19472221 |
| 99 | learning (GO:0007612) | 3.18764520 |
| 100 | dendrite morphogenesis (GO:0048813) | 3.15484325 |
| 101 | positive regulation of dendrite development (GO:1900006) | 3.15290770 |
| 102 | serotonin metabolic process (GO:0042428) | 3.14823250 |
| 103 | vesicle docking involved in exocytosis (GO:0006904) | 3.14308113 |
| 104 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.12836622 |
| 105 | response to amphetamine (GO:0001975) | 3.12655463 |
| 106 | positive regulation of synaptic transmission (GO:0050806) | 3.12385584 |
| 107 | visual learning (GO:0008542) | 3.12323067 |
| 108 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.12305718 |
| 109 | regulation of vesicle fusion (GO:0031338) | 3.12137889 |
| 110 | mechanosensory behavior (GO:0007638) | 3.10945681 |
| 111 | phosphorelay signal transduction system (GO:0000160) | 3.10258039 |
| 112 | behavioral response to cocaine (GO:0048148) | 3.10134692 |
| 113 | cell communication by electrical coupling (GO:0010644) | 3.09709706 |
| 114 | behavioral fear response (GO:0001662) | 3.08581448 |
| 115 | behavioral defense response (GO:0002209) | 3.08581448 |
| 116 | L-amino acid import (GO:0043092) | 3.07979987 |
| 117 | membrane depolarization during action potential (GO:0086010) | 3.06889587 |
| 118 | vesicle transport along microtubule (GO:0047496) | 3.06030512 |
| 119 | cellular sodium ion homeostasis (GO:0006883) | 3.05196998 |
| 120 | regulation of exocytosis (GO:0017157) | 3.04437148 |
| 121 | regulation of synaptic transmission (GO:0050804) | 3.03679474 |
| 122 | cochlea development (GO:0090102) | 3.00180574 |
| 123 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.00047068 |
| 124 | social behavior (GO:0035176) | 2.99005983 |
| 125 | intraspecies interaction between organisms (GO:0051703) | 2.99005983 |
| 126 | neuron recognition (GO:0008038) | 2.97651946 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.67670718 |
| 2 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 3.61002446 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.07431832 |
| 4 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.03981944 |
| 5 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.99490642 |
| 6 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.93829273 |
| 7 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.93568809 |
| 8 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.84688183 |
| 9 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.83499630 |
| 10 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.81682557 |
| 11 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.81682557 |
| 12 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.74440237 |
| 13 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.59172329 |
| 14 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.56850412 |
| 15 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.53010888 |
| 16 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.50130489 |
| 17 | * REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.47925928 |
| 18 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.43095148 |
| 19 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.41861183 |
| 20 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.41196427 |
| 21 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.37430545 |
| 22 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.35029247 |
| 23 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.33575981 |
| 24 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.30445504 |
| 25 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 2.13913548 |
| 26 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.08761190 |
| 27 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.98541023 |
| 28 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.96230523 |
| 29 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.93935734 |
| 30 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.76220560 |
| 31 | * ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.70104014 |
| 32 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.69569470 |
| 33 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.68798903 |
| 34 | * KDM2B_26808549_Chip-Seq_K562_Human | 1.68118233 |
| 35 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.52173967 |
| 36 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.47473714 |
| 37 | * WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.43652543 |
| 38 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.42571077 |
| 39 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.40458603 |
| 40 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.39173892 |
| 41 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.38749200 |
| 42 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.36407956 |
| 43 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.35981710 |
| 44 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.35683124 |
| 45 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.33615041 |
| 46 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.31490467 |
| 47 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.28020078 |
| 48 | * RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.27873308 |
| 49 | * SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.26743951 |
| 50 | AR_19668381_ChIP-Seq_PC3_Human | 1.22232054 |
| 51 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.19290399 |
| 52 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.18152482 |
| 53 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.17692114 |
| 54 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.17304035 |
| 55 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.17150503 |
| 56 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.14632152 |
| 57 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.14289074 |
| 58 | * CTCF_27219007_Chip-Seq_Bcells_Human | 1.13343962 |
| 59 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.11313176 |
| 60 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.11110708 |
| 61 | * TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.10358940 |
| 62 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.08742802 |
| 63 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.07836543 |
| 64 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.06557499 |
| 65 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.02859472 |
| 66 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.02831115 |
| 67 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.00894963 |
| 68 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.00472276 |
| 69 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.00073453 |
| 70 | * LXR_22292898_ChIP-Seq_THP-1_Human | 0.99716711 |
| 71 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.97693490 |
| 72 | STAT3_23295773_ChIP-Seq_U87_Human | 0.97374466 |
| 73 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.96727789 |
| 74 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.95317252 |
| 75 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.94869466 |
| 76 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.94665964 |
| 77 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.94554908 |
| 78 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.94489265 |
| 79 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.93331879 |
| 80 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.93151326 |
| 81 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.93131916 |
| 82 | P68_20966046_ChIP-Seq_HELA_Human | 0.92676806 |
| 83 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.92491630 |
| 84 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.92293123 |
| 85 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.92126749 |
| 86 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.91539857 |
| 87 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 0.91512682 |
| 88 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.90154543 |
| 89 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 0.89803961 |
| 90 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.89604984 |
| 91 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.88904325 |
| 92 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.88824420 |
| 93 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.87909276 |
| 94 | * SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.87208588 |
| 95 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.86763193 |
| 96 | OCT4_19829295_ChIP-Seq_ESCs_Human | 0.86605823 |
| 97 | AR_25329375_ChIP-Seq_VCAP_Human | 0.85446343 |
| 98 | * SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.84669703 |
| 99 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.84641932 |
| 100 | RXR_22108803_ChIP-Seq_LS180_Human | 0.83148335 |
| 101 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.83119013 |
| 102 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.83080191 |
| 103 | TCF4_23295773_ChIP-Seq_U87_Human | 0.82816076 |
| 104 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.81949205 |
| 105 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.81523261 |
| 106 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.81523261 |
| 107 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.80070411 |
| 108 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.78764646 |
| 109 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.77832735 |
| 110 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.77048112 |
| 111 | * DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.77026461 |
| 112 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.74515207 |
| 113 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.73841911 |
| 114 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.73340078 |
| 115 | SMAD4_21741376_ChIP-Seq_ESCs_Human | 0.73115802 |
| 116 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.72708587 |
| 117 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.72401958 |
| 118 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 0.70281025 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 7.64108623 |
| 2 | MP0002822_catalepsy | 5.37396949 |
| 3 | * MP0003635_abnormal_synaptic_transmissio | 4.41790281 |
| 4 | MP0003880_abnormal_central_pattern | 4.28875817 |
| 5 | MP0004270_analgesia | 3.87259322 |
| 6 | MP0002063_abnormal_learning/memory/cond | 3.64251800 |
| 7 | * MP0009745_abnormal_behavioral_response | 3.56536432 |
| 8 | MP0002064_seizures | 3.22798881 |
| 9 | MP0009046_muscle_twitch | 2.98887227 |
| 10 | MP0005423_abnormal_somatic_nervous | 2.84063286 |
| 11 | * MP0002572_abnormal_emotion/affect_behav | 2.79448908 |
| 12 | MP0001486_abnormal_startle_reflex | 2.75555872 |
| 13 | MP0001968_abnormal_touch/_nociception | 2.72323458 |
| 14 | MP0002272_abnormal_nervous_system | 2.54625098 |
| 15 | MP0002734_abnormal_mechanical_nocicepti | 2.53270679 |
| 16 | MP0002909_abnormal_adrenal_gland | 2.14876080 |
| 17 | MP0008569_lethality_at_weaning | 2.01608130 |
| 18 | MP0009780_abnormal_chondrocyte_physiolo | 2.01030337 |
| 19 | MP0004811_abnormal_neuron_physiology | 1.98881185 |
| 20 | MP0004858_abnormal_nervous_system | 1.98324850 |
| 21 | MP0002733_abnormal_thermal_nociception | 1.95792979 |
| 22 | MP0001970_abnormal_pain_threshold | 1.93592162 |
| 23 | MP0002736_abnormal_nociception_after | 1.85626236 |
| 24 | MP0002557_abnormal_social/conspecific_i | 1.74528752 |
| 25 | MP0005386_behavior/neurological_phenoty | 1.73842948 |
| 26 | MP0004924_abnormal_behavior | 1.73842948 |
| 27 | MP0003329_amyloid_beta_deposits | 1.72458314 |
| 28 | MP0005646_abnormal_pituitary_gland | 1.71409742 |
| 29 | MP0004885_abnormal_endolymph | 1.67518911 |
| 30 | MP0002735_abnormal_chemical_nociception | 1.65178372 |
| 31 | MP0002067_abnormal_sensory_capabilities | 1.65065396 |
| 32 | MP0003879_abnormal_hair_cell | 1.61406753 |
| 33 | * MP0001501_abnormal_sleep_pattern | 1.59238418 |
| 34 | MP0000955_abnormal_spinal_cord | 1.58350710 |
| 35 | MP0002184_abnormal_innervation | 1.57080270 |
| 36 | MP0000778_abnormal_nervous_system | 1.51028979 |
| 37 | MP0003075_altered_response_to | 1.49163394 |
| 38 | MP0003283_abnormal_digestive_organ | 1.48158617 |
| 39 | * MP0001440_abnormal_grooming_behavior | 1.48143847 |
| 40 | MP0003633_abnormal_nervous_system | 1.47890874 |
| 41 | MP0001529_abnormal_vocalization | 1.46409425 |
| 42 | MP0002066_abnormal_motor_capabilities/c | 1.42960734 |
| 43 | MP0001984_abnormal_olfaction | 1.42609313 |
| 44 | MP0002882_abnormal_neuron_morphology | 1.37750622 |
| 45 | MP0003123_paternal_imprinting | 1.24183065 |
| 46 | MP0008961_abnormal_basal_metabolism | 1.22465913 |
| 47 | MP0008872_abnormal_physiological_respon | 1.20758186 |
| 48 | MP0003631_nervous_system_phenotype | 1.18686818 |
| 49 | MP0005167_abnormal_blood-brain_barrier | 1.18388528 |
| 50 | MP0003787_abnormal_imprinting | 1.17686423 |
| 51 | MP0001177_atelectasis | 1.14200602 |
| 52 | MP0008874_decreased_physiological_sensi | 1.14154836 |
| 53 | MP0001348_abnormal_lacrimal_gland | 1.11718441 |
| 54 | * MP0002152_abnormal_brain_morphology | 1.09899375 |
| 55 | MP0001502_abnormal_circadian_rhythm | 1.09031362 |
| 56 | MP0000569_abnormal_digit_pigmentation | 1.02918319 |
| 57 | MP0004142_abnormal_muscle_tone | 1.02635679 |
| 58 | MP0001905_abnormal_dopamine_level | 1.01856522 |
| 59 | MP0005645_abnormal_hypothalamus_physiol | 1.01569021 |
| 60 | MP0002069_abnormal_eating/drinking_beha | 0.98736961 |
| 61 | MP0003690_abnormal_glial_cell | 0.98020582 |
| 62 | MP0010234_abnormal_vibrissa_follicle | 0.95605583 |
| 63 | MP0000013_abnormal_adipose_tissue | 0.93369019 |
| 64 | MP0005499_abnormal_olfactory_system | 0.86415254 |
| 65 | MP0005394_taste/olfaction_phenotype | 0.86415254 |
| 66 | MP0000751_myopathy | 0.84141868 |
| 67 | MP0004085_abnormal_heartbeat | 0.83636830 |
| 68 | MP0002229_neurodegeneration | 0.83250477 |
| 69 | MP0000920_abnormal_myelination | 0.83116223 |
| 70 | MP0001346_abnormal_lacrimal_gland | 0.82312716 |
| 71 | MP0003634_abnormal_glial_cell | 0.82101177 |
| 72 | MP0005535_abnormal_body_temperature | 0.81630729 |
| 73 | MP0002638_abnormal_pupillary_reflex | 0.81337692 |
| 74 | MP0005409_darkened_coat_color | 0.80607926 |
| 75 | MP0002090_abnormal_vision | 0.79917804 |
| 76 | MP0010386_abnormal_urinary_bladder | 0.79363931 |
| 77 | MP0001188_hyperpigmentation | 0.77134416 |
| 78 | MP0006276_abnormal_autonomic_nervous | 0.77010915 |
| 79 | MP0003632_abnormal_nervous_system | 0.76569958 |
| 80 | MP0008877_abnormal_DNA_methylation | 0.76465606 |
| 81 | MP0001986_abnormal_taste_sensitivity | 0.75356741 |
| 82 | MP0000604_amyloidosis | 0.73255823 |
| 83 | MP0004147_increased_porphyrin_level | 0.71775841 |
| 84 | MP0003172_abnormal_lysosome_physiology | 0.70597411 |
| 85 | MP0003137_abnormal_impulse_conducting | 0.70074953 |
| 86 | MP0003183_abnormal_peptide_metabolism | 0.69749075 |
| 87 | MP0005623_abnormal_meninges_morphology | 0.67411301 |
| 88 | MP0004233_abnormal_muscle_weight | 0.67000544 |
| 89 | MP0000631_abnormal_neuroendocrine_gland | 0.66670603 |
| 90 | MP0003122_maternal_imprinting | 0.59166259 |
| 91 | MP0000026_abnormal_inner_ear | 0.58766840 |
| 92 | MP0001963_abnormal_hearing_physiology | 0.58578972 |
| 93 | MP0001485_abnormal_pinna_reflex | 0.58562677 |
| 94 | MP0005166_decreased_susceptibility_to | 0.57778081 |
| 95 | MP0002752_abnormal_somatic_nervous | 0.56944214 |
| 96 | MP0003861_abnormal_nervous_system | 0.56764154 |
| 97 | MP0005551_abnormal_eye_electrophysiolog | 0.56372109 |
| 98 | MP0004145_abnormal_muscle_electrophysio | 0.56346600 |
| 99 | MP0004742_abnormal_vestibular_system | 0.55024499 |
| 100 | MP0010769_abnormal_survival | 0.54254439 |
| 101 | MP0004510_myositis | 0.54082505 |
| 102 | MP0002653_abnormal_ependyma_morphology | 0.53901878 |
| 103 | MP0001943_abnormal_respiration | 0.52834573 |
| 104 | MP0003956_abnormal_body_size | 0.51642947 |
| 105 | MP0010768_mortality/aging | 0.50900907 |
| 106 | MP0002089_abnormal_postnatal_growth/wei | 0.50654222 |
| 107 | MP0001664_abnormal_digestion | 0.50161587 |
| 108 | MP0010770_preweaning_lethality | 0.49326359 |
| 109 | MP0002082_postnatal_lethality | 0.49326359 |
| 110 | MP0002249_abnormal_larynx_morphology | 0.49116559 |
| 111 | MP0004130_abnormal_muscle_cell | 0.49010682 |
| 112 | MP0004043_abnormal_pH_regulation | 0.48545590 |
| 113 | MP0003938_abnormal_ear_development | 0.45413576 |
| 114 | MP0000639_abnormal_adrenal_gland | 0.44357139 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 8.69392295 |
| 2 | Focal motor seizures (HP:0011153) | 7.15646278 |
| 3 | Focal seizures (HP:0007359) | 5.61624528 |
| 4 | Visual hallucinations (HP:0002367) | 5.21312075 |
| 5 | Action tremor (HP:0002345) | 4.30521656 |
| 6 | Epileptic encephalopathy (HP:0200134) | 4.14417386 |
| 7 | Ankle clonus (HP:0011448) | 4.08789479 |
| 8 | Annular pancreas (HP:0001734) | 3.82744365 |
| 9 | Febrile seizures (HP:0002373) | 3.82712367 |
| 10 | Poor eye contact (HP:0000817) | 3.81252402 |
| 11 | Impaired vibration sensation in the lower limbs (HP:0002166) | 3.73198557 |
| 12 | Atonic seizures (HP:0010819) | 3.63800180 |
| 13 | Progressive cerebellar ataxia (HP:0002073) | 3.63635494 |
| 14 | Generalized tonic-clonic seizures (HP:0002069) | 3.60129379 |
| 15 | Depression (HP:0000716) | 3.59869165 |
| 16 | Abnormality of the lower motor neuron (HP:0002366) | 3.53166539 |
| 17 | Absence seizures (HP:0002121) | 3.51219153 |
| 18 | Torticollis (HP:0000473) | 3.49607792 |
| 19 | Papilledema (HP:0001085) | 3.47671241 |
| 20 | Urinary bladder sphincter dysfunction (HP:0002839) | 3.45822846 |
| 21 | Abnormal social behavior (HP:0012433) | 3.43992520 |
| 22 | Impaired social interactions (HP:0000735) | 3.43992520 |
| 23 | Supranuclear gaze palsy (HP:0000605) | 3.41829033 |
| 24 | Dysdiadochokinesis (HP:0002075) | 3.35418024 |
| 25 | Anxiety (HP:0000739) | 3.29516658 |
| 26 | Broad-based gait (HP:0002136) | 3.27689483 |
| 27 | Postural instability (HP:0002172) | 3.24232135 |
| 28 | Dialeptic seizures (HP:0011146) | 3.24181766 |
| 29 | Gaze-evoked nystagmus (HP:0000640) | 3.20137407 |
| 30 | Focal dystonia (HP:0004373) | 3.17205309 |
| 31 | Dysmetria (HP:0001310) | 3.07961209 |
| 32 | Mutism (HP:0002300) | 3.03295141 |
| 33 | Urinary urgency (HP:0000012) | 3.03245880 |
| 34 | Cerebral hypomyelination (HP:0006808) | 3.00356179 |
| 35 | Resting tremor (HP:0002322) | 2.94905512 |
| 36 | Craniofacial dystonia (HP:0012179) | 2.89318348 |
| 37 | Pointed chin (HP:0000307) | 2.89081950 |
| 38 | Intention tremor (HP:0002080) | 2.84453788 |
| 39 | Impaired smooth pursuit (HP:0007772) | 2.83881762 |
| 40 | Megalencephaly (HP:0001355) | 2.80871279 |
| 41 | Abnormal eating behavior (HP:0100738) | 2.79060335 |
| 42 | Stereotypic behavior (HP:0000733) | 2.77641850 |
| 43 | Ventricular fibrillation (HP:0001663) | 2.77044106 |
| 44 | Spastic gait (HP:0002064) | 2.73616281 |
| 45 | Truncal ataxia (HP:0002078) | 2.69889768 |
| 46 | Akinesia (HP:0002304) | 2.67542814 |
| 47 | Ankyloglossia (HP:0010296) | 2.66185996 |
| 48 | Amblyopia (HP:0000646) | 2.64671272 |
| 49 | Hemiplegia (HP:0002301) | 2.64541264 |
| 50 | Bradykinesia (HP:0002067) | 2.61902658 |
| 51 | Genetic anticipation (HP:0003743) | 2.61159263 |
| 52 | Peripheral hypomyelination (HP:0007182) | 2.60784587 |
| 53 | Impaired vibratory sensation (HP:0002495) | 2.54117294 |
| 54 | Sleep apnea (HP:0010535) | 2.53950106 |
| 55 | Insomnia (HP:0100785) | 2.53794397 |
| 56 | Spastic tetraparesis (HP:0001285) | 2.52575492 |
| 57 | Dysmetric saccades (HP:0000641) | 2.52389269 |
| 58 | Obstructive sleep apnea (HP:0002870) | 2.49880304 |
| 59 | Scanning speech (HP:0002168) | 2.47272879 |
| 60 | Hemiparesis (HP:0001269) | 2.46240403 |
| 61 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.44913860 |
| 62 | Bundle branch block (HP:0011710) | 2.42619668 |
| 63 | Clonus (HP:0002169) | 2.33556248 |
| 64 | Lower limb amyotrophy (HP:0007210) | 2.33386321 |
| 65 | Lower limb muscle weakness (HP:0007340) | 2.26265240 |
| 66 | Neurofibrillary tangles (HP:0002185) | 2.21029225 |
| 67 | Status epilepticus (HP:0002133) | 2.21014337 |
| 68 | Polyphagia (HP:0002591) | 2.14961310 |
| 69 | Cerebral inclusion bodies (HP:0100314) | 2.13766066 |
| 70 | Abnormal EKG (HP:0003115) | 2.12072540 |
| 71 | Abnormality of the periventricular white matter (HP:0002518) | 2.11398612 |
| 72 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.11360526 |
| 73 | Diplopia (HP:0000651) | 2.10579216 |
| 74 | Abnormality of binocular vision (HP:0011514) | 2.10579216 |
| 75 | Progressive inability to walk (HP:0002505) | 2.09253923 |
| 76 | Fetal akinesia sequence (HP:0001989) | 2.08043109 |
| 77 | Incomplete penetrance (HP:0003829) | 2.07424053 |
| 78 | Limb dystonia (HP:0002451) | 2.06141202 |
| 79 | Insidious onset (HP:0003587) | 2.06100414 |
| 80 | Termporal pattern (HP:0011008) | 2.06100414 |
| 81 | Epileptiform EEG discharges (HP:0011182) | 2.05021897 |
| 82 | Polygenic inheritance (HP:0010982) | 2.04950140 |
| 83 | Drooling (HP:0002307) | 2.04804885 |
| 84 | Excessive salivation (HP:0003781) | 2.04804885 |
| 85 | EEG with generalized epileptiform discharges (HP:0011198) | 2.03731165 |
| 86 | Apathy (HP:0000741) | 2.02064012 |
| 87 | Hypsarrhythmia (HP:0002521) | 2.01206214 |
| 88 | Hyperventilation (HP:0002883) | 2.00121032 |
| 89 | Choreoathetosis (HP:0001266) | 1.99016691 |
| 90 | Lower limb asymmetry (HP:0100559) | 1.97382852 |
| 91 | Amyotrophic lateral sclerosis (HP:0007354) | 1.95671590 |
| 92 | Tetraplegia (HP:0002445) | 1.89907401 |
| 93 | Abnormality of oral frenula (HP:0000190) | 1.89072776 |
| 94 | Neuronal loss in central nervous system (HP:0002529) | 1.87942628 |
| 95 | Generalized myoclonic seizures (HP:0002123) | 1.87761880 |
| 96 | Distal upper limb amyotrophy (HP:0007149) | 1.87530568 |
| 97 | Upper limb amyotrophy (HP:0009129) | 1.87530568 |
| 98 | Abnormality of the corticospinal tract (HP:0002492) | 1.86578147 |
| 99 | Prolonged QT interval (HP:0001657) | 1.86228837 |
| 100 | CNS hypomyelination (HP:0003429) | 1.84315564 |
| 101 | Rigidity (HP:0002063) | 1.83104856 |
| 102 | Abnormality of saccadic eye movements (HP:0000570) | 1.82365181 |
| 103 | Gait ataxia (HP:0002066) | 1.79708002 |
| 104 | Dementia (HP:0000726) | 1.79068557 |
| 105 | Rapidly progressive (HP:0003678) | 1.78107558 |
| 106 | Diminished motivation (HP:0000745) | 1.76958277 |
| 107 | Spinal canal stenosis (HP:0003416) | 1.75070822 |
| 108 | Intellectual disability, profound (HP:0002187) | 1.74845387 |
| 109 | Delusions (HP:0000746) | 1.74476337 |
| 110 | Memory impairment (HP:0002354) | 1.73820770 |
| 111 | Absent speech (HP:0001344) | 1.73369743 |
| 112 | Split foot (HP:0001839) | 1.73316677 |
| 113 | Aplasia involving bones of the extremities (HP:0009825) | 1.70206574 |
| 114 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.70206574 |
| 115 | Aplasia of the phalanges of the hand (HP:0009802) | 1.70206574 |
| 116 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.70054160 |
| 117 | Bronchomalacia (HP:0002780) | 1.67992336 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 5.88231378 |
| 2 | MAP3K9 | 4.09779632 |
| 3 | NTRK3 | 3.99317134 |
| 4 | PRKD3 | 3.17256993 |
| 5 | DAPK2 | 3.12397280 |
| 6 | KSR2 | 2.64929101 |
| 7 | MARK1 | 2.59236802 |
| 8 | MINK1 | 2.58114870 |
| 9 | PAK6 | 2.46817833 |
| 10 | CAMKK1 | 2.45289080 |
| 11 | MAP3K4 | 2.24958298 |
| 12 | NTRK1 | 2.06923216 |
| 13 | NTRK2 | 2.06652806 |
| 14 | DAPK1 | 1.80437952 |
| 15 | RIPK4 | 1.79591829 |
| 16 | TYRO3 | 1.75117635 |
| 17 | CASK | 1.69939608 |
| 18 | CDK5 | 1.65542146 |
| 19 | TAOK1 | 1.65387487 |
| 20 | KSR1 | 1.63745327 |
| 21 | MAP2K7 | 1.60531314 |
| 22 | PRPF4B | 1.52133992 |
| 23 | STK38 | 1.50963229 |
| 24 | MAP3K2 | 1.43990292 |
| 25 | FES | 1.38355696 |
| 26 | SIK2 | 1.37615745 |
| 27 | ARAF | 1.34708541 |
| 28 | MAP2K4 | 1.33957605 |
| 29 | MAP3K13 | 1.29221748 |
| 30 | UHMK1 | 1.24908773 |
| 31 | ALK | 1.18084416 |
| 32 | GRK5 | 1.15301586 |
| 33 | PINK1 | 1.14581474 |
| 34 | TNIK | 1.06069894 |
| 35 | PRKCG | 1.05083578 |
| 36 | RIPK1 | 1.03837472 |
| 37 | STK11 | 1.03117697 |
| 38 | CAMKK2 | 1.02617344 |
| 39 | PRKCH | 0.99516291 |
| 40 | RAF1 | 0.98642591 |
| 41 | CAMK1 | 0.96734331 |
| 42 | NEK1 | 0.96254655 |
| 43 | CDK15 | 0.95062505 |
| 44 | CDK18 | 0.93939031 |
| 45 | LATS2 | 0.91546009 |
| 46 | CDK19 | 0.88329111 |
| 47 | CDK14 | 0.86858449 |
| 48 | PLK2 | 0.85244190 |
| 49 | RET | 0.83881622 |
| 50 | CDK11A | 0.83571022 |
| 51 | MAP3K12 | 0.83244100 |
| 52 | MARK2 | 0.82957273 |
| 53 | BRSK1 | 0.82864304 |
| 54 | SGK223 | 0.81467771 |
| 55 | SGK494 | 0.81467771 |
| 56 | PKN1 | 0.80973435 |
| 57 | MAPK13 | 0.80701814 |
| 58 | PHKG1 | 0.80189135 |
| 59 | PHKG2 | 0.80189135 |
| 60 | TNK2 | 0.76846097 |
| 61 | MAPK12 | 0.75849007 |
| 62 | MAP3K11 | 0.75471368 |
| 63 | PDK1 | 0.74796110 |
| 64 | SGK3 | 0.73358734 |
| 65 | LMTK2 | 0.72954945 |
| 66 | CAMK2A | 0.71225984 |
| 67 | PDPK1 | 0.69633261 |
| 68 | SGK1 | 0.68389074 |
| 69 | MAP3K1 | 0.65593583 |
| 70 | ICK | 0.63576057 |
| 71 | SGK2 | 0.62839772 |
| 72 | TRIB3 | 0.60452845 |
| 73 | DDR2 | 0.58940862 |
| 74 | PTK2B | 0.57818083 |
| 75 | CAMK4 | 0.57756515 |
| 76 | PAK3 | 0.57449454 |
| 77 | DAPK3 | 0.56680290 |
| 78 | SCYL2 | 0.56564271 |
| 79 | CAMK2B | 0.56311156 |
| 80 | RPS6KA3 | 0.55451783 |
| 81 | CAMK1G | 0.53733325 |
| 82 | NEK6 | 0.53245145 |
| 83 | PRKCZ | 0.52499735 |
| 84 | CDC42BPA | 0.52303325 |
| 85 | BMPR2 | 0.52194149 |
| 86 | BMX | 0.51394221 |
| 87 | BRAF | 0.50008602 |
| 88 | MAPK10 | 0.49669047 |
| 89 | PRKD2 | 0.48311104 |
| 90 | FYN | 0.47351475 |
| 91 | DYRK1A | 0.45525430 |
| 92 | MAP2K1 | 0.45451638 |
| 93 | CAMK1D | 0.45311247 |
| 94 | MAP3K7 | 0.45117409 |
| 95 | PNCK | 0.44629207 |
| 96 | PDGFRA | 0.44367452 |
| 97 | DMPK | 0.43039855 |
| 98 | PRKG2 | 0.40837451 |
| 99 | CSNK1G2 | 0.40613403 |
| 100 | ERBB2 | 0.39074329 |
| 101 | PRKCA | 0.38984846 |
| 102 | MAP2K6 | 0.34747405 |
| 103 | LIMK1 | 0.31138613 |
| 104 | CAMK2G | 0.29975777 |
| 105 | FGFR2 | 0.28701712 |
| 106 | FGR | 0.28505985 |
| 107 | PRKCB | 0.28423334 |
| 108 | INSRR | 0.28307560 |
| 109 | WNK1 | 0.28151145 |
| 110 | MAPK8 | 0.27986805 |
| 111 | RPS6KA2 | 0.26529674 |
| 112 | MAP3K6 | 0.26467682 |
| 113 | CAMK2D | 0.25735599 |
| 114 | PRKCE | 0.25101033 |
| 115 | SRC | 0.24425454 |
| 116 | IRAK2 | 0.24040069 |
| 117 | OXSR1 | 0.23587735 |
| 118 | GSK3B | 0.23119033 |
| 119 | MAPK4 | 0.22780590 |
| 120 | PRKACA | 0.22404698 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Olfactory transduction_Homo sapiens_hsa04740 | 3.30724880 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.12515644 |
| 3 | Nicotine addiction_Homo sapiens_hsa05033 | 3.02641642 |
| 4 | Circadian entrainment_Homo sapiens_hsa04713 | 2.68802003 |
| 5 | Long-term potentiation_Homo sapiens_hsa04720 | 2.63845713 |
| 6 | GABAergic synapse_Homo sapiens_hsa04727 | 2.61661405 |
| 7 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.54661484 |
| 8 | Morphine addiction_Homo sapiens_hsa05032 | 2.52806410 |
| 9 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.51354954 |
| 10 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.35148791 |
| 11 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.22915108 |
| 12 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.21026224 |
| 13 | Salivary secretion_Homo sapiens_hsa04970 | 2.12333251 |
| 14 | Cholinergic synapse_Homo sapiens_hsa04725 | 2.08022085 |
| 15 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.98924458 |
| 16 | Insulin secretion_Homo sapiens_hsa04911 | 1.97764026 |
| 17 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.95569841 |
| 18 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.93978847 |
| 19 | Cocaine addiction_Homo sapiens_hsa05030 | 1.93222526 |
| 20 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.80381377 |
| 21 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.73255344 |
| 22 | Renin secretion_Homo sapiens_hsa04924 | 1.63341739 |
| 23 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.55414088 |
| 24 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.53860316 |
| 25 | Long-term depression_Homo sapiens_hsa04730 | 1.51244920 |
| 26 | Gap junction_Homo sapiens_hsa04540 | 1.47662655 |
| 27 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.43048905 |
| 28 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.37867704 |
| 29 | Taste transduction_Homo sapiens_hsa04742 | 1.37738820 |
| 30 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.36173594 |
| 31 | Glioma_Homo sapiens_hsa05214 | 1.35270297 |
| 32 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.32414968 |
| 33 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.32365992 |
| 34 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.30696410 |
| 35 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.24343685 |
| 36 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.21299668 |
| 37 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.15092892 |
| 38 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.13807340 |
| 39 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.10791443 |
| 40 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.06274106 |
| 41 | Melanogenesis_Homo sapiens_hsa04916 | 1.05894826 |
| 42 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.02592159 |
| 43 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.01078121 |
| 44 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 1.00114366 |
| 45 | Axon guidance_Homo sapiens_hsa04360 | 0.97870096 |
| 46 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.97785363 |
| 47 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.91834260 |
| 48 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.90933175 |
| 49 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.79909369 |
| 50 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.79077335 |
| 51 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.78618167 |
| 52 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.78150916 |
| 53 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.77562918 |
| 54 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.76797914 |
| 55 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.76049400 |
| 56 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.74416246 |
| 57 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.74328700 |
| 58 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.72738018 |
| 59 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.71885118 |
| 60 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.71830063 |
| 61 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.71716475 |
| 62 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.71498816 |
| 63 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.71053582 |
| 64 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.68969715 |
| 65 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.68876289 |
| 66 | Alcoholism_Homo sapiens_hsa05034 | 0.68152728 |
| 67 | Endocytosis_Homo sapiens_hsa04144 | 0.64045665 |
| 68 | Endometrial cancer_Homo sapiens_hsa05213 | 0.63915941 |
| 69 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.61878013 |
| 70 | Bile secretion_Homo sapiens_hsa04976 | 0.61219053 |
| 71 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.59994227 |
| 72 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.59423443 |
| 73 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.59301953 |
| 74 | Phototransduction_Homo sapiens_hsa04744 | 0.58020108 |
| 75 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.57494379 |
| 76 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.57010571 |
| 77 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.55674306 |
| 78 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.55328027 |
| 79 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.51266149 |
| 80 | Prion diseases_Homo sapiens_hsa05020 | 0.50246239 |
| 81 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.48924980 |
| 82 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.46978975 |
| 83 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.46587382 |
| 84 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.46480912 |
| 85 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.46285211 |
| 86 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.45241593 |
| 87 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.45032856 |
| 88 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.42684740 |
| 89 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.42060883 |
| 90 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.41087876 |
| 91 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.39794665 |
| 92 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.39068775 |
| 93 | Circadian rhythm_Homo sapiens_hsa04710 | 0.38584397 |
| 94 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.37806135 |
| 95 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.36363948 |
| 96 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.35383510 |
| 97 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.33158936 |
| 98 | Platelet activation_Homo sapiens_hsa04611 | 0.31745469 |
| 99 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.31628977 |
| 100 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.31549280 |
| 101 | Colorectal cancer_Homo sapiens_hsa05210 | 0.30481854 |
| 102 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.30084551 |
| 103 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.29666825 |
| 104 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.26055882 |
| 105 | Tight junction_Homo sapiens_hsa04530 | 0.19515117 |
| 106 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.18495555 |
| 107 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.18340113 |
| 108 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.16958866 |
| 109 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.15324230 |
| 110 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.14474421 |

