DLGAP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.89487943
2locomotory exploration behavior (GO:0035641)6.54169584
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.51142902
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.41046206
5vocalization behavior (GO:0071625)5.76740138
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.75726859
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.61666943
8regulation of synapse structural plasticity (GO:0051823)5.48425991
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.45656292
10synaptic vesicle exocytosis (GO:0016079)5.31663694
11regulation of glutamate receptor signaling pathway (GO:1900449)5.29419601
12glutamate secretion (GO:0014047)5.15788604
13regulation of neuronal synaptic plasticity (GO:0048168)5.15155606
14regulation of long-term neuronal synaptic plasticity (GO:0048169)5.15135762
15regulation of synaptic vesicle exocytosis (GO:2000300)5.12162268
16dendritic spine morphogenesis (GO:0060997)4.85408831
17exploration behavior (GO:0035640)4.77865917
18cerebellar granule cell differentiation (GO:0021707)4.73818190
19layer formation in cerebral cortex (GO:0021819)4.71770839
20protein localization to synapse (GO:0035418)4.71373524
21regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.60636364
22neurotransmitter-gated ion channel clustering (GO:0072578)4.59871770
23neurotransmitter secretion (GO:0007269)4.58659587
24regulation of synaptic vesicle transport (GO:1902803)4.54288233
25postsynaptic membrane organization (GO:0001941)4.53650499
26ionotropic glutamate receptor signaling pathway (GO:0035235)4.50250930
27neuronal action potential propagation (GO:0019227)4.35935126
28regulation of dendritic spine morphogenesis (GO:0061001)4.33827587
29amino acid import (GO:0043090)4.32743197
30prepulse inhibition (GO:0060134)4.32040589
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.28628225
32neuromuscular process controlling balance (GO:0050885)4.27868373
33negative regulation of synaptic transmission, GABAergic (GO:0032229)4.27494026
34auditory behavior (GO:0031223)4.24687058
35positive regulation of membrane potential (GO:0045838)4.22938050
36synaptic transmission, glutamatergic (GO:0035249)4.19759161
37long-term memory (GO:0007616)4.15572196
38gamma-aminobutyric acid transport (GO:0015812)4.09016147
39regulation of excitatory postsynaptic membrane potential (GO:0060079)4.05469482
40positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.03710579
41regulation of synapse maturation (GO:0090128)4.02867578
42neuron-neuron synaptic transmission (GO:0007270)3.94655937
43gamma-aminobutyric acid signaling pathway (GO:0007214)3.93147648
44positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.91972742
45regulation of synaptic plasticity (GO:0048167)3.90036946
46positive regulation of synaptic transmission, GABAergic (GO:0032230)3.89713243
47regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.85192247
48response to auditory stimulus (GO:0010996)3.81857212
49G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.80314286
50positive regulation of neurotransmitter transport (GO:0051590)3.79091662
51glutamate receptor signaling pathway (GO:0007215)3.78743495
52neuron cell-cell adhesion (GO:0007158)3.78247895
53activation of protein kinase A activity (GO:0034199)3.78144312
54regulation of postsynaptic membrane potential (GO:0060078)3.77223591
55proline transport (GO:0015824)3.75654398
56cellular potassium ion homeostasis (GO:0030007)3.71300533
57negative regulation of dendrite morphogenesis (GO:0050774)3.70152196
58sodium ion export (GO:0071436)3.67074423
59potassium ion homeostasis (GO:0055075)3.64752520
60positive regulation of neurotransmitter secretion (GO:0001956)3.64516037
61glycine transport (GO:0015816)3.63344708
62positive regulation of synapse maturation (GO:0090129)3.62133851
63dendritic spine organization (GO:0097061)3.57794472
64transmission of nerve impulse (GO:0019226)3.57681355
65neuronal ion channel clustering (GO:0045161)3.54292658
66regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.53840427
67neurotransmitter transport (GO:0006836)3.53484744
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.51143577
69regulation of neurotransmitter secretion (GO:0046928)3.47917306
70chemosensory behavior (GO:0007635)3.47350549
71central nervous system myelination (GO:0022010)3.46727483
72axon ensheathment in central nervous system (GO:0032291)3.46727483
73potassium ion import (GO:0010107)3.46322622
74regulation of dendritic spine development (GO:0060998)3.46112375
75neuromuscular synaptic transmission (GO:0007274)3.44963114
76cytoskeletal anchoring at plasma membrane (GO:0007016)3.41672728
77positive regulation of dendritic spine development (GO:0060999)3.40946438
78adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.38543206
79neuromuscular process controlling posture (GO:0050884)3.38414953
80regulation of neurotransmitter levels (GO:0001505)3.38142541
81acidic amino acid transport (GO:0015800)3.34851573
82dopamine receptor signaling pathway (GO:0007212)3.33937513
83adenosine receptor signaling pathway (GO:0001973)3.33589497
84regulation of neurotransmitter transport (GO:0051588)3.32928302
85synaptic transmission, dopaminergic (GO:0001963)3.32064599
86long-term synaptic potentiation (GO:0060291)3.31148806
87negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.29625113
88regulation of ARF protein signal transduction (GO:0032012)3.28859176
89regulation of female receptivity (GO:0045924)3.27032742
90membrane hyperpolarization (GO:0060081)3.26301266
91synaptic transmission (GO:0007268)3.25766300
92striatum development (GO:0021756)3.24900412
93synaptic vesicle endocytosis (GO:0048488)3.24405394
94neuromuscular process (GO:0050905)3.24260759
95cell differentiation in hindbrain (GO:0021533)3.24095441
96positive regulation of dendritic spine morphogenesis (GO:0061003)3.21623448
97cell migration in hindbrain (GO:0021535)3.20770876
98membrane depolarization (GO:0051899)3.19472221
99learning (GO:0007612)3.18764520
100dendrite morphogenesis (GO:0048813)3.15484325
101positive regulation of dendrite development (GO:1900006)3.15290770
102serotonin metabolic process (GO:0042428)3.14823250
103vesicle docking involved in exocytosis (GO:0006904)3.14308113
104cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.12836622
105response to amphetamine (GO:0001975)3.12655463
106positive regulation of synaptic transmission (GO:0050806)3.12385584
107visual learning (GO:0008542)3.12323067
108regulation of voltage-gated calcium channel activity (GO:1901385)3.12305718
109regulation of vesicle fusion (GO:0031338)3.12137889
110mechanosensory behavior (GO:0007638)3.10945681
111phosphorelay signal transduction system (GO:0000160)3.10258039
112behavioral response to cocaine (GO:0048148)3.10134692
113cell communication by electrical coupling (GO:0010644)3.09709706
114behavioral fear response (GO:0001662)3.08581448
115behavioral defense response (GO:0002209)3.08581448
116L-amino acid import (GO:0043092)3.07979987
117membrane depolarization during action potential (GO:0086010)3.06889587
118vesicle transport along microtubule (GO:0047496)3.06030512
119cellular sodium ion homeostasis (GO:0006883)3.05196998
120regulation of exocytosis (GO:0017157)3.04437148
121regulation of synaptic transmission (GO:0050804)3.03679474
122cochlea development (GO:0090102)3.00180574
123cerebellar Purkinje cell differentiation (GO:0021702)3.00047068
124social behavior (GO:0035176)2.99005983
125intraspecies interaction between organisms (GO:0051703)2.99005983
126neuron recognition (GO:0008038)2.97651946

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.67670718
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.61002446
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07431832
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03981944
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99490642
6DROSHA_22980978_ChIP-Seq_HELA_Human2.93829273
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.93568809
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.84688183
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.83499630
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.81682557
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.81682557
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74440237
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.59172329
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56850412
15GBX2_23144817_ChIP-Seq_PC3_Human2.53010888
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50130489
17* REST_18959480_ChIP-ChIP_MESCs_Mouse2.47925928
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.43095148
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.41861183
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41196427
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.37430545
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35029247
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.33575981
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.30445504
25ERG_21242973_ChIP-ChIP_JURKAT_Human2.13913548
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.08761190
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.98541023
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96230523
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93935734
30AR_21572438_ChIP-Seq_LNCaP_Human1.76220560
31* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.70104014
32DNAJC2_21179169_ChIP-ChIP_NT2_Human1.69569470
33* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.68798903
34* KDM2B_26808549_Chip-Seq_K562_Human1.68118233
35EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.52173967
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.47473714
37* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43652543
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42571077
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40458603
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39173892
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38749200
42GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36407956
43CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35981710
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35683124
45WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33615041
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.31490467
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28020078
48* RING1B_27294783_Chip-Seq_NPCs_Mouse1.27873308
49* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26743951
50AR_19668381_ChIP-Seq_PC3_Human1.22232054
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19290399
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18152482
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17692114
54SMAD4_21799915_ChIP-Seq_A2780_Human1.17304035
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.17150503
56RNF2_27304074_Chip-Seq_NSC_Mouse1.14632152
57P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14289074
58* CTCF_27219007_Chip-Seq_Bcells_Human1.13343962
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11313176
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11110708
61* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10358940
62TET1_21490601_ChIP-Seq_MESCs_Mouse1.08742802
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07836543
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.06557499
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02859472
66DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02831115
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00894963
68SMAD3_21741376_ChIP-Seq_HESCs_Human1.00472276
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00073453
70* LXR_22292898_ChIP-Seq_THP-1_Human0.99716711
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97693490
72STAT3_23295773_ChIP-Seq_U87_Human0.97374466
73ZNF274_21170338_ChIP-Seq_K562_Hela0.96727789
74KLF4_19829295_ChIP-Seq_ESCs_Human0.95317252
75* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94869466
76YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94665964
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94554908
78SMAD3_21741376_ChIP-Seq_EPCs_Human0.94489265
79KDM2B_26808549_Chip-Seq_DND41_Human0.93331879
80ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93151326
81SMC4_20622854_ChIP-Seq_HELA_Human0.93131916
82P68_20966046_ChIP-Seq_HELA_Human0.92676806
83PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92491630
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92293123
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92126749
86KDM2B_26808549_Chip-Seq_JURKAT_Human0.91539857
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91512682
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90154543
89TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.89803961
90SMAD3_21741376_ChIP-Seq_ESCs_Human0.89604984
91SMAD4_21741376_ChIP-Seq_HESCs_Human0.88904325
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88824420
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87909276
94* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87208588
95SMAD_19615063_ChIP-ChIP_OVARY_Human0.86763193
96OCT4_19829295_ChIP-Seq_ESCs_Human0.86605823
97AR_25329375_ChIP-Seq_VCAP_Human0.85446343
98* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84669703
99ESR2_21235772_ChIP-Seq_MCF-7_Human0.84641932
100RXR_22108803_ChIP-Seq_LS180_Human0.83148335
101OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83119013
102BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83080191
103TCF4_23295773_ChIP-Seq_U87_Human0.82816076
104AHR_22903824_ChIP-Seq_MCF-7_Human0.81949205
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81523261
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81523261
107GATA1_26923725_Chip-Seq_HPCs_Mouse0.80070411
108CREB1_26743006_Chip-Seq_LNCaP_Human0.78764646
109ARNT_22903824_ChIP-Seq_MCF-7_Human0.77832735
110TP53_20018659_ChIP-ChIP_R1E_Mouse0.77048112
111* DPY_21335234_ChIP-Seq_ESCs_Mouse0.77026461
112SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.74515207
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73841911
114EGR1_19032775_ChIP-ChIP_M12_Human0.73340078
115SMAD4_21741376_ChIP-Seq_ESCs_Human0.73115802
116TET1_21451524_ChIP-Seq_MESCs_Mouse0.72708587
117CTNNB1_20460455_ChIP-Seq_HCT116_Human0.72401958
118MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.70281025

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.64108623
2MP0002822_catalepsy5.37396949
3* MP0003635_abnormal_synaptic_transmissio4.41790281
4MP0003880_abnormal_central_pattern4.28875817
5MP0004270_analgesia3.87259322
6MP0002063_abnormal_learning/memory/cond3.64251800
7* MP0009745_abnormal_behavioral_response3.56536432
8MP0002064_seizures3.22798881
9MP0009046_muscle_twitch2.98887227
10MP0005423_abnormal_somatic_nervous2.84063286
11* MP0002572_abnormal_emotion/affect_behav2.79448908
12MP0001486_abnormal_startle_reflex2.75555872
13MP0001968_abnormal_touch/_nociception2.72323458
14MP0002272_abnormal_nervous_system2.54625098
15MP0002734_abnormal_mechanical_nocicepti2.53270679
16MP0002909_abnormal_adrenal_gland2.14876080
17MP0008569_lethality_at_weaning2.01608130
18MP0009780_abnormal_chondrocyte_physiolo2.01030337
19MP0004811_abnormal_neuron_physiology1.98881185
20MP0004858_abnormal_nervous_system1.98324850
21MP0002733_abnormal_thermal_nociception1.95792979
22MP0001970_abnormal_pain_threshold1.93592162
23MP0002736_abnormal_nociception_after1.85626236
24MP0002557_abnormal_social/conspecific_i1.74528752
25MP0005386_behavior/neurological_phenoty1.73842948
26MP0004924_abnormal_behavior1.73842948
27MP0003329_amyloid_beta_deposits1.72458314
28MP0005646_abnormal_pituitary_gland1.71409742
29MP0004885_abnormal_endolymph1.67518911
30MP0002735_abnormal_chemical_nociception1.65178372
31MP0002067_abnormal_sensory_capabilities1.65065396
32MP0003879_abnormal_hair_cell1.61406753
33* MP0001501_abnormal_sleep_pattern1.59238418
34MP0000955_abnormal_spinal_cord1.58350710
35MP0002184_abnormal_innervation1.57080270
36MP0000778_abnormal_nervous_system1.51028979
37MP0003075_altered_response_to1.49163394
38MP0003283_abnormal_digestive_organ1.48158617
39* MP0001440_abnormal_grooming_behavior1.48143847
40MP0003633_abnormal_nervous_system1.47890874
41MP0001529_abnormal_vocalization1.46409425
42MP0002066_abnormal_motor_capabilities/c1.42960734
43MP0001984_abnormal_olfaction1.42609313
44MP0002882_abnormal_neuron_morphology1.37750622
45MP0003123_paternal_imprinting1.24183065
46MP0008961_abnormal_basal_metabolism1.22465913
47MP0008872_abnormal_physiological_respon1.20758186
48MP0003631_nervous_system_phenotype1.18686818
49MP0005167_abnormal_blood-brain_barrier1.18388528
50MP0003787_abnormal_imprinting1.17686423
51MP0001177_atelectasis1.14200602
52MP0008874_decreased_physiological_sensi1.14154836
53MP0001348_abnormal_lacrimal_gland1.11718441
54* MP0002152_abnormal_brain_morphology1.09899375
55MP0001502_abnormal_circadian_rhythm1.09031362
56MP0000569_abnormal_digit_pigmentation1.02918319
57MP0004142_abnormal_muscle_tone1.02635679
58MP0001905_abnormal_dopamine_level1.01856522
59MP0005645_abnormal_hypothalamus_physiol1.01569021
60MP0002069_abnormal_eating/drinking_beha0.98736961
61MP0003690_abnormal_glial_cell0.98020582
62MP0010234_abnormal_vibrissa_follicle0.95605583
63MP0000013_abnormal_adipose_tissue0.93369019
64MP0005499_abnormal_olfactory_system0.86415254
65MP0005394_taste/olfaction_phenotype0.86415254
66MP0000751_myopathy0.84141868
67MP0004085_abnormal_heartbeat0.83636830
68MP0002229_neurodegeneration0.83250477
69MP0000920_abnormal_myelination0.83116223
70MP0001346_abnormal_lacrimal_gland0.82312716
71MP0003634_abnormal_glial_cell0.82101177
72MP0005535_abnormal_body_temperature0.81630729
73MP0002638_abnormal_pupillary_reflex0.81337692
74MP0005409_darkened_coat_color0.80607926
75MP0002090_abnormal_vision0.79917804
76MP0010386_abnormal_urinary_bladder0.79363931
77MP0001188_hyperpigmentation0.77134416
78MP0006276_abnormal_autonomic_nervous0.77010915
79MP0003632_abnormal_nervous_system0.76569958
80MP0008877_abnormal_DNA_methylation0.76465606
81MP0001986_abnormal_taste_sensitivity0.75356741
82MP0000604_amyloidosis0.73255823
83MP0004147_increased_porphyrin_level0.71775841
84MP0003172_abnormal_lysosome_physiology0.70597411
85MP0003137_abnormal_impulse_conducting0.70074953
86MP0003183_abnormal_peptide_metabolism0.69749075
87MP0005623_abnormal_meninges_morphology0.67411301
88MP0004233_abnormal_muscle_weight0.67000544
89MP0000631_abnormal_neuroendocrine_gland0.66670603
90MP0003122_maternal_imprinting0.59166259
91MP0000026_abnormal_inner_ear0.58766840
92MP0001963_abnormal_hearing_physiology0.58578972
93MP0001485_abnormal_pinna_reflex0.58562677
94MP0005166_decreased_susceptibility_to0.57778081
95MP0002752_abnormal_somatic_nervous0.56944214
96MP0003861_abnormal_nervous_system0.56764154
97MP0005551_abnormal_eye_electrophysiolog0.56372109
98MP0004145_abnormal_muscle_electrophysio0.56346600
99MP0004742_abnormal_vestibular_system0.55024499
100MP0010769_abnormal_survival0.54254439
101MP0004510_myositis0.54082505
102MP0002653_abnormal_ependyma_morphology0.53901878
103MP0001943_abnormal_respiration0.52834573
104MP0003956_abnormal_body_size0.51642947
105MP0010768_mortality/aging0.50900907
106MP0002089_abnormal_postnatal_growth/wei0.50654222
107MP0001664_abnormal_digestion0.50161587
108MP0010770_preweaning_lethality0.49326359
109MP0002082_postnatal_lethality0.49326359
110MP0002249_abnormal_larynx_morphology0.49116559
111MP0004130_abnormal_muscle_cell0.49010682
112MP0004043_abnormal_pH_regulation0.48545590
113MP0003938_abnormal_ear_development0.45413576
114MP0000639_abnormal_adrenal_gland0.44357139

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.69392295
2Focal motor seizures (HP:0011153)7.15646278
3Focal seizures (HP:0007359)5.61624528
4Visual hallucinations (HP:0002367)5.21312075
5Action tremor (HP:0002345)4.30521656
6Epileptic encephalopathy (HP:0200134)4.14417386
7Ankle clonus (HP:0011448)4.08789479
8Annular pancreas (HP:0001734)3.82744365
9Febrile seizures (HP:0002373)3.82712367
10Poor eye contact (HP:0000817)3.81252402
11Impaired vibration sensation in the lower limbs (HP:0002166)3.73198557
12Atonic seizures (HP:0010819)3.63800180
13Progressive cerebellar ataxia (HP:0002073)3.63635494
14Generalized tonic-clonic seizures (HP:0002069)3.60129379
15Depression (HP:0000716)3.59869165
16Abnormality of the lower motor neuron (HP:0002366)3.53166539
17Absence seizures (HP:0002121)3.51219153
18Torticollis (HP:0000473)3.49607792
19Papilledema (HP:0001085)3.47671241
20Urinary bladder sphincter dysfunction (HP:0002839)3.45822846
21Abnormal social behavior (HP:0012433)3.43992520
22Impaired social interactions (HP:0000735)3.43992520
23Supranuclear gaze palsy (HP:0000605)3.41829033
24Dysdiadochokinesis (HP:0002075)3.35418024
25Anxiety (HP:0000739)3.29516658
26Broad-based gait (HP:0002136)3.27689483
27Postural instability (HP:0002172)3.24232135
28Dialeptic seizures (HP:0011146)3.24181766
29Gaze-evoked nystagmus (HP:0000640)3.20137407
30Focal dystonia (HP:0004373)3.17205309
31Dysmetria (HP:0001310)3.07961209
32Mutism (HP:0002300)3.03295141
33Urinary urgency (HP:0000012)3.03245880
34Cerebral hypomyelination (HP:0006808)3.00356179
35Resting tremor (HP:0002322)2.94905512
36Craniofacial dystonia (HP:0012179)2.89318348
37Pointed chin (HP:0000307)2.89081950
38Intention tremor (HP:0002080)2.84453788
39Impaired smooth pursuit (HP:0007772)2.83881762
40Megalencephaly (HP:0001355)2.80871279
41Abnormal eating behavior (HP:0100738)2.79060335
42Stereotypic behavior (HP:0000733)2.77641850
43Ventricular fibrillation (HP:0001663)2.77044106
44Spastic gait (HP:0002064)2.73616281
45Truncal ataxia (HP:0002078)2.69889768
46Akinesia (HP:0002304)2.67542814
47Ankyloglossia (HP:0010296)2.66185996
48Amblyopia (HP:0000646)2.64671272
49Hemiplegia (HP:0002301)2.64541264
50Bradykinesia (HP:0002067)2.61902658
51Genetic anticipation (HP:0003743)2.61159263
52Peripheral hypomyelination (HP:0007182)2.60784587
53Impaired vibratory sensation (HP:0002495)2.54117294
54Sleep apnea (HP:0010535)2.53950106
55Insomnia (HP:0100785)2.53794397
56Spastic tetraparesis (HP:0001285)2.52575492
57Dysmetric saccades (HP:0000641)2.52389269
58Obstructive sleep apnea (HP:0002870)2.49880304
59Scanning speech (HP:0002168)2.47272879
60Hemiparesis (HP:0001269)2.46240403
61Abnormality of ocular smooth pursuit (HP:0000617)2.44913860
62Bundle branch block (HP:0011710)2.42619668
63Clonus (HP:0002169)2.33556248
64Lower limb amyotrophy (HP:0007210)2.33386321
65Lower limb muscle weakness (HP:0007340)2.26265240
66Neurofibrillary tangles (HP:0002185)2.21029225
67Status epilepticus (HP:0002133)2.21014337
68Polyphagia (HP:0002591)2.14961310
69Cerebral inclusion bodies (HP:0100314)2.13766066
70Abnormal EKG (HP:0003115)2.12072540
71Abnormality of the periventricular white matter (HP:0002518)2.11398612
72Morphological abnormality of the pyramidal tract (HP:0002062)2.11360526
73Diplopia (HP:0000651)2.10579216
74Abnormality of binocular vision (HP:0011514)2.10579216
75Progressive inability to walk (HP:0002505)2.09253923
76Fetal akinesia sequence (HP:0001989)2.08043109
77Incomplete penetrance (HP:0003829)2.07424053
78Limb dystonia (HP:0002451)2.06141202
79Insidious onset (HP:0003587)2.06100414
80Termporal pattern (HP:0011008)2.06100414
81Epileptiform EEG discharges (HP:0011182)2.05021897
82Polygenic inheritance (HP:0010982)2.04950140
83Drooling (HP:0002307)2.04804885
84Excessive salivation (HP:0003781)2.04804885
85EEG with generalized epileptiform discharges (HP:0011198)2.03731165
86Apathy (HP:0000741)2.02064012
87Hypsarrhythmia (HP:0002521)2.01206214
88Hyperventilation (HP:0002883)2.00121032
89Choreoathetosis (HP:0001266)1.99016691
90Lower limb asymmetry (HP:0100559)1.97382852
91Amyotrophic lateral sclerosis (HP:0007354)1.95671590
92Tetraplegia (HP:0002445)1.89907401
93Abnormality of oral frenula (HP:0000190)1.89072776
94Neuronal loss in central nervous system (HP:0002529)1.87942628
95Generalized myoclonic seizures (HP:0002123)1.87761880
96Distal upper limb amyotrophy (HP:0007149)1.87530568
97Upper limb amyotrophy (HP:0009129)1.87530568
98Abnormality of the corticospinal tract (HP:0002492)1.86578147
99Prolonged QT interval (HP:0001657)1.86228837
100CNS hypomyelination (HP:0003429)1.84315564
101Rigidity (HP:0002063)1.83104856
102Abnormality of saccadic eye movements (HP:0000570)1.82365181
103Gait ataxia (HP:0002066)1.79708002
104Dementia (HP:0000726)1.79068557
105Rapidly progressive (HP:0003678)1.78107558
106Diminished motivation (HP:0000745)1.76958277
107Spinal canal stenosis (HP:0003416)1.75070822
108Intellectual disability, profound (HP:0002187)1.74845387
109Delusions (HP:0000746)1.74476337
110Memory impairment (HP:0002354)1.73820770
111Absent speech (HP:0001344)1.73369743
112Split foot (HP:0001839)1.73316677
113Aplasia involving bones of the extremities (HP:0009825)1.70206574
114Aplasia involving bones of the upper limbs (HP:0009823)1.70206574
115Aplasia of the phalanges of the hand (HP:0009802)1.70206574
116Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70054160
117Bronchomalacia (HP:0002780)1.67992336

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.88231378
2MAP3K94.09779632
3NTRK33.99317134
4PRKD33.17256993
5DAPK23.12397280
6KSR22.64929101
7MARK12.59236802
8MINK12.58114870
9PAK62.46817833
10CAMKK12.45289080
11MAP3K42.24958298
12NTRK12.06923216
13NTRK22.06652806
14DAPK11.80437952
15RIPK41.79591829
16TYRO31.75117635
17CASK1.69939608
18CDK51.65542146
19TAOK11.65387487
20KSR11.63745327
21MAP2K71.60531314
22PRPF4B1.52133992
23STK381.50963229
24MAP3K21.43990292
25FES1.38355696
26SIK21.37615745
27ARAF1.34708541
28MAP2K41.33957605
29MAP3K131.29221748
30UHMK11.24908773
31ALK1.18084416
32GRK51.15301586
33PINK11.14581474
34TNIK1.06069894
35PRKCG1.05083578
36RIPK11.03837472
37STK111.03117697
38CAMKK21.02617344
39PRKCH0.99516291
40RAF10.98642591
41CAMK10.96734331
42NEK10.96254655
43CDK150.95062505
44CDK180.93939031
45LATS20.91546009
46CDK190.88329111
47CDK140.86858449
48PLK20.85244190
49RET0.83881622
50CDK11A0.83571022
51MAP3K120.83244100
52MARK20.82957273
53BRSK10.82864304
54SGK2230.81467771
55SGK4940.81467771
56PKN10.80973435
57MAPK130.80701814
58PHKG10.80189135
59PHKG20.80189135
60TNK20.76846097
61MAPK120.75849007
62MAP3K110.75471368
63PDK10.74796110
64SGK30.73358734
65LMTK20.72954945
66CAMK2A0.71225984
67PDPK10.69633261
68SGK10.68389074
69MAP3K10.65593583
70ICK0.63576057
71SGK20.62839772
72TRIB30.60452845
73DDR20.58940862
74PTK2B0.57818083
75CAMK40.57756515
76PAK30.57449454
77DAPK30.56680290
78SCYL20.56564271
79CAMK2B0.56311156
80RPS6KA30.55451783
81CAMK1G0.53733325
82NEK60.53245145
83PRKCZ0.52499735
84CDC42BPA0.52303325
85BMPR20.52194149
86BMX0.51394221
87BRAF0.50008602
88MAPK100.49669047
89PRKD20.48311104
90FYN0.47351475
91DYRK1A0.45525430
92MAP2K10.45451638
93CAMK1D0.45311247
94MAP3K70.45117409
95PNCK0.44629207
96PDGFRA0.44367452
97DMPK0.43039855
98PRKG20.40837451
99CSNK1G20.40613403
100ERBB20.39074329
101PRKCA0.38984846
102MAP2K60.34747405
103LIMK10.31138613
104CAMK2G0.29975777
105FGFR20.28701712
106FGR0.28505985
107PRKCB0.28423334
108INSRR0.28307560
109WNK10.28151145
110MAPK80.27986805
111RPS6KA20.26529674
112MAP3K60.26467682
113CAMK2D0.25735599
114PRKCE0.25101033
115SRC0.24425454
116IRAK20.24040069
117OXSR10.23587735
118GSK3B0.23119033
119MAPK40.22780590
120PRKACA0.22404698

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.30724880
2Synaptic vesicle cycle_Homo sapiens_hsa047213.12515644
3Nicotine addiction_Homo sapiens_hsa050333.02641642
4Circadian entrainment_Homo sapiens_hsa047132.68802003
5Long-term potentiation_Homo sapiens_hsa047202.63845713
6GABAergic synapse_Homo sapiens_hsa047272.61661405
7Glutamatergic synapse_Homo sapiens_hsa047242.54661484
8Morphine addiction_Homo sapiens_hsa050322.52806410
9Amphetamine addiction_Homo sapiens_hsa050312.51354954
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35148791
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22915108
12Dopaminergic synapse_Homo sapiens_hsa047282.21026224
13Salivary secretion_Homo sapiens_hsa049702.12333251
14Cholinergic synapse_Homo sapiens_hsa047252.08022085
15Nitrogen metabolism_Homo sapiens_hsa009101.98924458
16Insulin secretion_Homo sapiens_hsa049111.97764026
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.95569841
18Gastric acid secretion_Homo sapiens_hsa049711.93978847
19Cocaine addiction_Homo sapiens_hsa050301.93222526
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.80381377
21Oxytocin signaling pathway_Homo sapiens_hsa049211.73255344
22Renin secretion_Homo sapiens_hsa049241.63341739
23Calcium signaling pathway_Homo sapiens_hsa040201.55414088
24GnRH signaling pathway_Homo sapiens_hsa049121.53860316
25Long-term depression_Homo sapiens_hsa047301.51244920
26Gap junction_Homo sapiens_hsa045401.47662655
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43048905
28Serotonergic synapse_Homo sapiens_hsa047261.37867704
29Taste transduction_Homo sapiens_hsa047421.37738820
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36173594
31Glioma_Homo sapiens_hsa052141.35270297
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32414968
33cAMP signaling pathway_Homo sapiens_hsa040241.32365992
34Vitamin B6 metabolism_Homo sapiens_hsa007501.30696410
35Type II diabetes mellitus_Homo sapiens_hsa049301.24343685
36Estrogen signaling pathway_Homo sapiens_hsa049151.21299668
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15092892
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13807340
39ErbB signaling pathway_Homo sapiens_hsa040121.10791443
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06274106
41Melanogenesis_Homo sapiens_hsa049161.05894826
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02592159
43Oocyte meiosis_Homo sapiens_hsa041141.01078121
44Phospholipase D signaling pathway_Homo sapiens_hsa040721.00114366
45Axon guidance_Homo sapiens_hsa043600.97870096
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97785363
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.91834260
48Dorso-ventral axis formation_Homo sapiens_hsa043200.90933175
49VEGF signaling pathway_Homo sapiens_hsa043700.79909369
50mTOR signaling pathway_Homo sapiens_hsa041500.79077335
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.78618167
52Pancreatic secretion_Homo sapiens_hsa049720.78150916
53Thyroid hormone synthesis_Homo sapiens_hsa049180.77562918
54Choline metabolism in cancer_Homo sapiens_hsa052310.76797914
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76049400
56Non-small cell lung cancer_Homo sapiens_hsa052230.74416246
57Collecting duct acid secretion_Homo sapiens_hsa049660.74328700
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72738018
59Dilated cardiomyopathy_Homo sapiens_hsa054140.71885118
60MAPK signaling pathway_Homo sapiens_hsa040100.71830063
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71716475
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71498816
63Rap1 signaling pathway_Homo sapiens_hsa040150.71053582
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68969715
65Cardiac muscle contraction_Homo sapiens_hsa042600.68876289
66Alcoholism_Homo sapiens_hsa050340.68152728
67Endocytosis_Homo sapiens_hsa041440.64045665
68Endometrial cancer_Homo sapiens_hsa052130.63915941
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61878013
70Bile secretion_Homo sapiens_hsa049760.61219053
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.59994227
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59423443
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59301953
74Phototransduction_Homo sapiens_hsa047440.58020108
75Ras signaling pathway_Homo sapiens_hsa040140.57494379
76Type I diabetes mellitus_Homo sapiens_hsa049400.57010571
77Glucagon signaling pathway_Homo sapiens_hsa049220.55674306
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55328027
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51266149
80Prion diseases_Homo sapiens_hsa050200.50246239
81Chemokine signaling pathway_Homo sapiens_hsa040620.48924980
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46978975
83Vibrio cholerae infection_Homo sapiens_hsa051100.46587382
84Insulin signaling pathway_Homo sapiens_hsa049100.46480912
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46285211
86Inositol phosphate metabolism_Homo sapiens_hsa005620.45241593
87Renal cell carcinoma_Homo sapiens_hsa052110.45032856
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42684740
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42060883
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41087876
91Wnt signaling pathway_Homo sapiens_hsa043100.39794665
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39068775
93Circadian rhythm_Homo sapiens_hsa047100.38584397
94Arginine and proline metabolism_Homo sapiens_hsa003300.37806135
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36363948
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35383510
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.33158936
98Platelet activation_Homo sapiens_hsa046110.31745469
99Arginine biosynthesis_Homo sapiens_hsa002200.31628977
100Ovarian steroidogenesis_Homo sapiens_hsa049130.31549280
101Colorectal cancer_Homo sapiens_hsa052100.30481854
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30084551
103African trypanosomiasis_Homo sapiens_hsa051430.29666825
104AMPK signaling pathway_Homo sapiens_hsa041520.26055882
105Tight junction_Homo sapiens_hsa045300.19515117
106HIF-1 signaling pathway_Homo sapiens_hsa040660.18495555
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.18340113
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.16958866
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15324230
110Hippo signaling pathway_Homo sapiens_hsa043900.14474421

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