DLGAP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. The protein encoded by this gene can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.80747120
2locomotory exploration behavior (GO:0035641)5.63891095
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.45305138
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.12611424
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.06830885
6vocalization behavior (GO:0071625)5.04484588
7synaptic vesicle docking involved in exocytosis (GO:0016081)4.98852111
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.87205872
9layer formation in cerebral cortex (GO:0021819)4.80580533
10synaptic vesicle exocytosis (GO:0016079)4.63454439
11regulation of synapse structural plasticity (GO:0051823)4.63033908
12regulation of synaptic vesicle exocytosis (GO:2000300)4.58946747
13glutamate secretion (GO:0014047)4.48509606
14regulation of glutamate receptor signaling pathway (GO:1900449)4.47628425
15protein localization to synapse (GO:0035418)4.23935561
16dendritic spine morphogenesis (GO:0060997)4.21995309
17exploration behavior (GO:0035640)4.16350269
18regulation of synaptic vesicle transport (GO:1902803)4.13426759
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.03307487
20regulation of neuronal synaptic plasticity (GO:0048168)4.02785728
21regulation of long-term neuronal synaptic plasticity (GO:0048169)3.94013023
22positive regulation of synapse maturation (GO:0090129)3.71940384
23neurotransmitter secretion (GO:0007269)3.66921305
24cell migration in hindbrain (GO:0021535)3.57025759
25synaptic transmission, glutamatergic (GO:0035249)3.55087656
26negative regulation of catenin import into nucleus (GO:0035414)3.52098098
27cell communication by electrical coupling (GO:0010644)3.50789944
28activation of protein kinase A activity (GO:0034199)3.49206102
29neuron cell-cell adhesion (GO:0007158)3.43403095
30neuromuscular process controlling balance (GO:0050885)3.41758308
31sodium ion export (GO:0071436)3.40707178
32long-term memory (GO:0007616)3.39247007
33dendrite morphogenesis (GO:0048813)3.37782291
34G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.36547783
35regulation of dendritic spine morphogenesis (GO:0061001)3.35419321
36glutamate receptor signaling pathway (GO:0007215)3.35288369
37proline transport (GO:0015824)3.33529004
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31792953
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.28690501
40semaphorin-plexin signaling pathway (GO:0071526)3.24838117
41cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.23175960
42neuron projection extension (GO:1990138)3.22622169
43neuronal action potential propagation (GO:0019227)3.22329783
44neurotransmitter-gated ion channel clustering (GO:0072578)3.21127614
45synaptic vesicle endocytosis (GO:0048488)3.20209025
46axonal fasciculation (GO:0007413)3.19828238
47regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.18907876
48neuron recognition (GO:0008038)3.18753249
49positive regulation of membrane potential (GO:0045838)3.18462884
50positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.17755048
51establishment of mitochondrion localization (GO:0051654)3.15593584
52regulation of postsynaptic membrane potential (GO:0060078)3.12650645
53regulation of ARF protein signal transduction (GO:0032012)3.12300451
54regulation of synaptic plasticity (GO:0048167)3.12138607
55cell-cell junction maintenance (GO:0045217)3.11127996
56cellular potassium ion homeostasis (GO:0030007)3.10605973
57protein retention in ER lumen (GO:0006621)3.07297584
58postsynaptic membrane organization (GO:0001941)3.06986926
59protein heterotrimerization (GO:0070208)3.06628005
60plasma membrane repair (GO:0001778)3.04902136
61neuron-neuron synaptic transmission (GO:0007270)3.04829347
62auditory behavior (GO:0031223)3.02366427
63pyrimidine nucleobase catabolic process (GO:0006208)3.00878347
64cerebellar Purkinje cell layer development (GO:0021680)2.99987689
65regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.99732551
66dendritic spine organization (GO:0097061)2.99564678
67regulation of neurotransmitter secretion (GO:0046928)2.96032030
68central nervous system projection neuron axonogenesis (GO:0021952)2.95947718
69regulation of vesicle fusion (GO:0031338)2.95356057
70response to auditory stimulus (GO:0010996)2.91414748
71regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.90683645
72establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.88593655
73mitochondrion transport along microtubule (GO:0047497)2.88593655
74maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.86020504
75establishment of nucleus localization (GO:0040023)2.84857356
76cerebellar Purkinje cell differentiation (GO:0021702)2.84601963
77positive regulation of neurotransmitter secretion (GO:0001956)2.84450508
78positive regulation of synaptic transmission, GABAergic (GO:0032230)2.84176518
79positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.83071827
80gamma-aminobutyric acid transport (GO:0015812)2.82307153
81cytoskeletal anchoring at plasma membrane (GO:0007016)2.82240987
82cerebellar granule cell differentiation (GO:0021707)2.82180285
83planar cell polarity pathway involved in neural tube closure (GO:0090179)2.81936404
84regulation of axon extension involved in axon guidance (GO:0048841)2.81837878
85regulation of dendritic spine development (GO:0060998)2.77274352
86neuromuscular process (GO:0050905)2.76645398
87response to pheromone (GO:0019236)2.73694984
88regulation of NFAT protein import into nucleus (GO:0051532)2.73200378
89membrane depolarization during action potential (GO:0086010)2.73114909
90positive regulation of neurotransmitter transport (GO:0051590)2.72098378
91prepulse inhibition (GO:0060134)2.72072509
92response to gravity (GO:0009629)2.70332373
93regulation of synapse maturation (GO:0090128)2.70137537
94neurotransmitter transport (GO:0006836)2.69137092
95innervation (GO:0060384)2.68460582
96vesicle transport along microtubule (GO:0047496)2.68306019
97membrane depolarization (GO:0051899)2.67991389
98regulation of neurotransmitter transport (GO:0051588)2.67864405
99positive regulation of synapse assembly (GO:0051965)2.67166750
100skin morphogenesis (GO:0043589)2.66308228
101neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.66022265
102response to parathyroid hormone (GO:0071107)2.65778727
103positive regulation of dendritic spine development (GO:0060999)2.65582038
104positive regulation of fibroblast migration (GO:0010763)2.65390963
105developmental cell growth (GO:0048588)2.64429399
106neuronal ion channel clustering (GO:0045161)2.64193219
107barbed-end actin filament capping (GO:0051016)2.63765758
108regulation of clathrin-mediated endocytosis (GO:2000369)2.63704154
109intraspecies interaction between organisms (GO:0051703)2.61914417
110social behavior (GO:0035176)2.61914417
111receptor recycling (GO:0001881)2.61090574
112regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.60707624
113neuron projection extension involved in neuron projection guidance (GO:1902284)2.58977729
114axon extension involved in axon guidance (GO:0048846)2.58977729
115regulation of synaptic transmission, glutamatergic (GO:0051966)2.57619043
116cell communication involved in cardiac conduction (GO:0086065)2.56800000
117respiratory system process (GO:0003016)2.56529271
118negative regulation of microtubule polymerization (GO:0031115)2.56267618
119regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.56018042
120dopamine receptor signaling pathway (GO:0007212)2.54355219
121axon extension (GO:0048675)2.53936990
122chemosensory behavior (GO:0007635)2.53188831
123long-term synaptic potentiation (GO:0060291)2.52672885
124basement membrane organization (GO:0071711)2.52591464
125camera-type eye morphogenesis (GO:0048593)2.52395390
126cell junction maintenance (GO:0034331)2.51905215
127adherens junction assembly (GO:0034333)2.51798075
128clathrin coat assembly (GO:0048268)2.51734457
129positive regulation of axon extension (GO:0045773)2.51550104
130regulation of neurotransmitter levels (GO:0001505)2.50665766
131cell adhesion mediated by integrin (GO:0033627)2.48758701
132regulation of axon guidance (GO:1902667)2.47751382
133stress fiber assembly (GO:0043149)2.46306632
134response to acidic pH (GO:0010447)2.42447262
135substrate-dependent cell migration (GO:0006929)2.41960608
136neuron remodeling (GO:0016322)2.41777414
137endothelial cell chemotaxis (GO:0035767)2.41659422
138protein targeting to plasma membrane (GO:0072661)2.38103116
139positive regulation of vesicle fusion (GO:0031340)2.36955353
140actin filament depolymerization (GO:0030042)2.36353790
141regulation of early endosome to late endosome transport (GO:2000641)2.34645013
142lens morphogenesis in camera-type eye (GO:0002089)2.32809902
143lens fiber cell development (GO:0070307)2.32265077
144chondrocyte proliferation (GO:0035988)2.28076268
145cranial nerve morphogenesis (GO:0021602)2.27292000
146cellular response to monoamine stimulus (GO:0071868)2.24474121
147cellular response to catecholamine stimulus (GO:0071870)2.24474121
148regulation of axon extension (GO:0030516)2.23169429
149regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.21343213
150cochlea morphogenesis (GO:0090103)2.20640726
151cellular response to prostaglandin stimulus (GO:0071379)2.19514668
152establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.19018621
153ganglion development (GO:0061548)2.18902291
154kidney mesenchyme development (GO:0072074)2.18062810
155adherens junction organization (GO:0034332)2.17951200
156negative regulation of axon extension involved in axon guidance (GO:0048843)2.17741409
157vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.17500074

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.57448206
2JARID2_20064375_ChIP-Seq_MESCs_Mouse2.80309646
3RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74198694
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74198694
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.73890741
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.71013807
7* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.70572895
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.70283709
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.67245154
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.62306611
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54973905
12DROSHA_22980978_ChIP-Seq_HELA_Human2.52488063
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.44611779
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.42082104
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.34935743
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34452383
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33526322
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33180665
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31520521
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28958026
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.28327439
22* REST_21632747_ChIP-Seq_MESCs_Mouse2.27926351
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26612232
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.26366226
25TRIM28_21343339_ChIP-Seq_HEK293_Human2.17623196
26* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.01804644
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99723424
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.97761218
29* REST_18959480_ChIP-ChIP_MESCs_Mouse1.92697331
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87549214
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.84605847
32* KDM2B_26808549_Chip-Seq_K562_Human1.84367157
33* ELK3_25401928_ChIP-Seq_HUVEC_Human1.80366768
34GBX2_23144817_ChIP-Seq_PC3_Human1.78418208
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74946494
36* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67563218
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65508468
38* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.58655061
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57694287
40ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53431934
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.52950987
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52736318
43* RACK7_27058665_Chip-Seq_MCF-7_Human1.51287624
44* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38916568
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38690739
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38303898
47* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37167685
48KDM2B_26808549_Chip-Seq_DND41_Human1.36487319
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34864526
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34819591
51* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34579463
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32698840
53RING1B_27294783_Chip-Seq_NPCs_Mouse1.32471773
54AR_21572438_ChIP-Seq_LNCaP_Human1.32231682
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31722737
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31167794
57LXR_22292898_ChIP-Seq_THP-1_Human1.30031383
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29515056
59* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29433913
60WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28688728
61NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27777043
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25566004
63TP53_22127205_ChIP-Seq_IMR90_Human1.25515507
64DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25122411
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24996725
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24816963
67RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22719378
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.22349966
69TP53_20018659_ChIP-ChIP_R1E_Mouse1.19974432
70CLOCK_20551151_ChIP-Seq_293T_Human1.19731787
71P68_20966046_ChIP-Seq_HELA_Human1.15276627
72P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14596126
73CTCF_27219007_Chip-Seq_Bcells_Human1.13850559
74AR_19668381_ChIP-Seq_PC3_Human1.12067307
75ZNF263_19887448_ChIP-Seq_K562_Human1.11214447
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09344372
77TET1_21451524_ChIP-Seq_MESCs_Mouse1.09002260
78TCF7_22412390_ChIP-Seq_EML_Mouse1.08310090
79* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08237331
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.06162431
81* TET1_21490601_ChIP-Seq_MESCs_Mouse1.05720969
82ESR1_21235772_ChIP-Seq_MCF-7_Human1.04880688
83ZNF274_21170338_ChIP-Seq_K562_Hela1.04213960
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03732051
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03633539
86SMC4_20622854_ChIP-Seq_HELA_Human1.01607373
87* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01547785
88* TP63_22573176_ChIP-Seq_HFKS_Human1.00462059
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99389664
90MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98814516
91* SOX2_21211035_ChIP-Seq_LN229_Gbm0.98692862
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96590314
93ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96562397
94SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95749254
95NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95697915
96SMAD_19615063_ChIP-ChIP_OVARY_Human0.94761125
97CBX2_27304074_Chip-Seq_ESCs_Mouse0.94197009
98P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94150566
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93514701
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92892779
101TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92642697
102* SMAD3_21741376_ChIP-Seq_HESCs_Human0.92469042
103SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91301114
104SMC3_22415368_ChIP-Seq_MEFs_Mouse0.91299347
105CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91113640
106NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90860021
107CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90755759
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90194087
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89962769
110KLF4_19829295_ChIP-Seq_ESCs_Human0.89889686
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89186046
112SMAD3_21741376_ChIP-Seq_ESCs_Human0.88846888
113CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88807071
114ESR2_21235772_ChIP-Seq_MCF-7_Human0.88184543
115SMAD4_21799915_ChIP-Seq_A2780_Human0.88165439
116YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87573026
117AHR_22903824_ChIP-Seq_MCF-7_Human0.87525217
118* SMAD4_21741376_ChIP-Seq_HESCs_Human0.86803602
119PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86146470
120CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86127211
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85451920
122ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85018870
123OCT4_19829295_ChIP-Seq_ESCs_Human0.83938479
124CREB1_26743006_Chip-Seq_LNCaP_Human0.83810577
125KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82123906
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82080273
127ARNT_22903824_ChIP-Seq_MCF-7_Human0.82079692
128* TP53_23651856_ChIP-Seq_MEFs_Mouse0.81210903
129ESR1_20079471_ChIP-ChIP_T-47D_Human0.80119831
130ELK4_26923725_Chip-Seq_MESODERM_Mouse0.80033314
131EP300_21415370_ChIP-Seq_HL-1_Mouse0.79769049

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.01550127
2MP0003635_abnormal_synaptic_transmissio3.87189144
3MP0004270_analgesia3.69173711
4MP0003880_abnormal_central_pattern3.47282347
5MP0008438_abnormal_cutaneous_collagen3.41716201
6MP0002063_abnormal_learning/memory/cond3.07353153
7MP0005257_abnormal_intraocular_pressure2.93934084
8MP0009745_abnormal_behavioral_response2.75066895
9MP0002064_seizures2.57450130
10MP0005423_abnormal_somatic_nervous2.49530527
11MP0004858_abnormal_nervous_system2.44889211
12MP0009046_muscle_twitch2.41794508
13MP0000751_myopathy2.32583798
14MP0003279_aneurysm2.26210023
15MP0002572_abnormal_emotion/affect_behav2.23677181
16MP0002734_abnormal_mechanical_nocicepti2.18554913
17MP0003123_paternal_imprinting2.18162978
18MP0001968_abnormal_touch/_nociception2.10806049
19MP0001958_emphysema2.04970854
20MP0009780_abnormal_chondrocyte_physiolo1.94862065
21MP0001486_abnormal_startle_reflex1.94668251
22MP0000778_abnormal_nervous_system1.92244087
23MP0004272_abnormal_basement_membrane1.88979894
24MP0005409_darkened_coat_color1.88431701
25MP0004811_abnormal_neuron_physiology1.85699718
26MP0002822_catalepsy1.83779266
27MP0002184_abnormal_innervation1.83135940
28MP0008569_lethality_at_weaning1.80011935
29MP0002909_abnormal_adrenal_gland1.79707162
30MP0001440_abnormal_grooming_behavior1.74992962
31MP0002733_abnormal_thermal_nociception1.74120559
32MP0005275_abnormal_skin_tensile1.72010986
33MP0002272_abnormal_nervous_system1.70208538
34MP0003879_abnormal_hair_cell1.69877070
35MP0010368_abnormal_lymphatic_system1.68759220
36MP0004510_myositis1.67211906
37MP0005503_abnormal_tendon_morphology1.66169487
38MP0001501_abnormal_sleep_pattern1.61452811
39MP0004145_abnormal_muscle_electrophysio1.61423970
40MP0001970_abnormal_pain_threshold1.59938857
41MP0003566_abnormal_cell_adhesion1.55318189
42MP0000569_abnormal_digit_pigmentation1.55119907
43MP0002557_abnormal_social/conspecific_i1.54968565
44MP0005623_abnormal_meninges_morphology1.54404699
45MP0003329_amyloid_beta_deposits1.50817684
46MP0000955_abnormal_spinal_cord1.50531990
47MP0008961_abnormal_basal_metabolism1.50474138
48MP0000566_synostosis1.47836222
49MP0009384_cardiac_valve_regurgitation1.46134114
50MP0002653_abnormal_ependyma_morphology1.45623894
51MP0002736_abnormal_nociception_after1.45282230
52MP0002067_abnormal_sensory_capabilities1.40612575
53MP0010030_abnormal_orbit_morphology1.39270795
54MP0001542_abnormal_bone_strength1.38988599
55MP0002882_abnormal_neuron_morphology1.33971135
56MP0002735_abnormal_chemical_nociception1.32198382
57MP0003303_peritoneal_inflammation1.29532238
58MP0002249_abnormal_larynx_morphology1.25760317
59MP0003787_abnormal_imprinting1.25737095
60MP0003942_abnormal_urinary_system1.25330150
61MP0000767_abnormal_smooth_muscle1.24999778
62MP0003283_abnormal_digestive_organ1.23308899
63MP0001849_ear_inflammation1.23029590
64MP0005386_behavior/neurological_phenoty1.22340014
65MP0004924_abnormal_behavior1.22340014
66MP0002066_abnormal_motor_capabilities/c1.20574662
67MP0003646_muscle_fatigue1.19520495
68MP0002152_abnormal_brain_morphology1.15467547
69MP0003122_maternal_imprinting1.14464671
70MP0002234_abnormal_pharynx_morphology1.12724052
71MP0004885_abnormal_endolymph1.09711735
72MP0004233_abnormal_muscle_weight1.08706257
73MP0005508_abnormal_skeleton_morphology1.07908496
74MP0000049_abnormal_middle_ear1.02576728
75MP0005058_abnormal_lysosome_morphology0.98115481
76MP0003137_abnormal_impulse_conducting0.97493699
77MP0003183_abnormal_peptide_metabolism0.96993041
78MP0003075_altered_response_to0.96671153
79MP0003633_abnormal_nervous_system0.96579618
80MP0002837_dystrophic_cardiac_calcinosis0.96185863
81MP0002116_abnormal_craniofacial_bone0.93554662
82MP0004085_abnormal_heartbeat0.93167197
83MP0000003_abnormal_adipose_tissue0.93137432
84MP0006276_abnormal_autonomic_nervous0.92511925
85MP0005499_abnormal_olfactory_system0.92355919
86MP0005394_taste/olfaction_phenotype0.92355919
87MP0004087_abnormal_muscle_fiber0.91682810
88MP0002896_abnormal_bone_mineralization0.91405920
89MP0005187_abnormal_penis_morphology0.90910589
90MP0000534_abnormal_ureter_morphology0.89997716
91MP0002108_abnormal_muscle_morphology0.89824994
92MP0000537_abnormal_urethra_morphology0.89650321
93MP0000759_abnormal_skeletal_muscle0.89470830
94MP0003861_abnormal_nervous_system0.88118676
95MP0003385_abnormal_body_wall0.87106108
96MP0001299_abnormal_eye_distance/0.86558709
97MP0001984_abnormal_olfaction0.86333019
98MP0005595_abnormal_vascular_smooth0.85846134
99MP0000749_muscle_degeneration0.85322300
100MP0004264_abnormal_extraembryonic_tissu0.85079460
101MP0002106_abnormal_muscle_physiology0.84886530
102MP0001502_abnormal_circadian_rhythm0.84053720
103MP0005167_abnormal_blood-brain_barrier0.83833924
104MP0000579_abnormal_nail_morphology0.82790058
105MP0003136_yellow_coat_color0.82728764
106MP0003121_genomic_imprinting0.81158946
107MP0003705_abnormal_hypodermis_morpholog0.80258427
108MP0000733_abnormal_muscle_development0.79571174
109MP0005620_abnormal_muscle_contractility0.78986103
110MP0000604_amyloidosis0.78370928
111MP0003631_nervous_system_phenotype0.78287574
112MP0005645_abnormal_hypothalamus_physiol0.77944824
113MP0003755_abnormal_palate_morphology0.77185489
114MP0005076_abnormal_cell_differentiation0.77122440
115MP0002069_abnormal_eating/drinking_beha0.77035864
116MP0003119_abnormal_digestive_system0.76949277
117MP0003948_abnormal_gas_homeostasis0.76208599
118MP0004130_abnormal_muscle_cell0.75944370
119MP0000013_abnormal_adipose_tissue0.75692071
120MP0002295_abnormal_pulmonary_circulatio0.75350096
121MP0002163_abnormal_gland_morphology0.74842664
122MP0009840_abnormal_foam_cell0.74629805
123MP0004215_abnormal_myocardial_fiber0.74333073
124MP0000747_muscle_weakness0.73794463
125MP0000163_abnormal_cartilage_morphology0.73379922
126MP0003091_abnormal_cell_migration0.73241887
127MP0000762_abnormal_tongue_morphology0.73126621
128MP0000750_abnormal_muscle_regeneration0.73012307
129MP0005369_muscle_phenotype0.71499591
130MP0004484_altered_response_of0.71356881
131MP0008874_decreased_physiological_sensi0.69623386
132MP0005646_abnormal_pituitary_gland0.69256657
133MP0004084_abnormal_cardiac_muscle0.68678217
134MP0002089_abnormal_postnatal_growth/wei0.67933615
135MP0003634_abnormal_glial_cell0.65790580
136MP0003045_fibrosis0.65101558
137MP0001177_atelectasis0.64332700
138MP0002752_abnormal_somatic_nervous0.63175150
139MP0010234_abnormal_vibrissa_follicle0.62495632
140MP0001348_abnormal_lacrimal_gland0.62056889
141MP0002972_abnormal_cardiac_muscle0.60766400

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.39676355
2Focal motor seizures (HP:0011153)4.80182807
3Focal seizures (HP:0007359)4.24346365
4Protrusio acetabuli (HP:0003179)4.20593457
5Premature rupture of membranes (HP:0001788)4.06180759
6Visual hallucinations (HP:0002367)3.99094242
7Fetal akinesia sequence (HP:0001989)3.28405939
8Progressive cerebellar ataxia (HP:0002073)3.17529111
9Ankle clonus (HP:0011448)3.11755510
10Bladder diverticulum (HP:0000015)3.00472912
11Action tremor (HP:0002345)2.97805279
12Genetic anticipation (HP:0003743)2.95210191
13Supranuclear gaze palsy (HP:0000605)2.93756068
14Epileptic encephalopathy (HP:0200134)2.86443888
15Neonatal short-limb short stature (HP:0008921)2.85872321
16Mutism (HP:0002300)2.84441783
17Spinal rigidity (HP:0003306)2.80194083
18Neurofibrillary tangles (HP:0002185)2.80106321
19Hand muscle atrophy (HP:0009130)2.79923893
20Amblyopia (HP:0000646)2.73880371
21Mitral regurgitation (HP:0001653)2.70130795
22Ankle contracture (HP:0006466)2.68526018
23Atrophic scars (HP:0001075)2.68044242
24Absence seizures (HP:0002121)2.67740876
25Depression (HP:0000716)2.66615667
26Febrile seizures (HP:0002373)2.63383332
27Broad metatarsal (HP:0001783)2.63357109
28Long toe (HP:0010511)2.61874837
29Obstructive sleep apnea (HP:0002870)2.59841479
30Pointed chin (HP:0000307)2.57652579
31Atonic seizures (HP:0010819)2.57264480
32Broad-based gait (HP:0002136)2.55222205
33Ventricular fibrillation (HP:0001663)2.54121514
34Cerebral inclusion bodies (HP:0100314)2.53668046
35Generalized tonic-clonic seizures (HP:0002069)2.53608854
36Abnormality of the lower motor neuron (HP:0002366)2.51825638
37Poor eye contact (HP:0000817)2.50536806
38Bundle branch block (HP:0011710)2.49800440
39Lower limb amyotrophy (HP:0007210)2.48767689
40Vertebral arch anomaly (HP:0008438)2.47333448
41Sudden death (HP:0001699)2.43637021
42Impaired vibration sensation in the lower limbs (HP:0002166)2.40309880
43Urinary bladder sphincter dysfunction (HP:0002839)2.39332697
44Annular pancreas (HP:0001734)2.36916051
45Renal duplication (HP:0000075)2.33200724
46Sleep apnea (HP:0010535)2.31555922
47Abnormal social behavior (HP:0012433)2.31216537
48Impaired social interactions (HP:0000735)2.31216537
49Apathy (HP:0000741)2.29648921
50Abnormality of the Achilles tendon (HP:0005109)2.29428457
51Flared iliac wings (HP:0002869)2.29172152
52Fragile skin (HP:0001030)2.28682487
53Abnormality of dentin (HP:0010299)2.26863387
54Turricephaly (HP:0000262)2.26236714
55Dialeptic seizures (HP:0011146)2.26102099
56Neoplasm of the heart (HP:0100544)2.25493759
57Hemiparesis (HP:0001269)2.23973495
58Shallow orbits (HP:0000586)2.22668465
59Dysdiadochokinesis (HP:0002075)2.22563812
60Difficulty running (HP:0009046)2.21917727
61Aortic dissection (HP:0002647)2.21240762
62Megalencephaly (HP:0001355)2.20749824
63Aortic aneurysm (HP:0004942)2.19262427
64Urinary urgency (HP:0000012)2.18117142
65Vascular tortuosity (HP:0004948)2.17826364
66Hemiplegia (HP:0002301)2.16832839
67Stereotypic behavior (HP:0000733)2.12341814
68Torticollis (HP:0000473)2.12112247
69Abnormal eating behavior (HP:0100738)2.11889359
70Hyperacusis (HP:0010780)2.09955485
71Papilledema (HP:0001085)2.09950080
72Genu recurvatum (HP:0002816)2.06878319
73Akinesia (HP:0002304)2.06856195
74Diminished motivation (HP:0000745)2.06756030
75Peritonitis (HP:0002586)2.06648799
76Bowel diverticulosis (HP:0005222)2.06432922
77Disproportionate tall stature (HP:0001519)2.04970311
78Insomnia (HP:0100785)2.04441223
79Elfin facies (HP:0004428)2.02303179
80Increased connective tissue (HP:0009025)2.01899420
81J-shaped sella turcica (HP:0002680)2.01415808
82Distal upper limb amyotrophy (HP:0007149)2.00847381
83Upper limb amyotrophy (HP:0009129)2.00847381
84Difficulty climbing stairs (HP:0003551)2.00097883
85Arterial tortuosity (HP:0005116)1.97256516
86Postural instability (HP:0002172)1.97171380
87Wide anterior fontanel (HP:0000260)1.96895740
88Rapidly progressive (HP:0003678)1.96728752
89Slender build (HP:0001533)1.95935499
90Large eyes (HP:0001090)1.94959923
91Type 1 muscle fiber predominance (HP:0003803)1.93521052
92Exercise-induced myalgia (HP:0003738)1.93238193
93Impaired smooth pursuit (HP:0007772)1.93073149
94Soft skin (HP:0000977)1.92782872
95Agitation (HP:0000713)1.92744836
96Cervical subluxation (HP:0003308)1.92544964
97Renovascular hypertension (HP:0100817)1.92266141
98Excessive salivation (HP:0003781)1.90954333
99Drooling (HP:0002307)1.90954333
100Gaze-evoked nystagmus (HP:0000640)1.90186329
101Increased variability in muscle fiber diameter (HP:0003557)1.89837991
102Abnormality of the calf musculature (HP:0001430)1.89672689
103Follicular hyperkeratosis (HP:0007502)1.89647916
104Shoulder girdle muscle weakness (HP:0003547)1.88367804
105Flat cornea (HP:0007720)1.87763728
106Dysmetria (HP:0001310)1.87654294
107Anxiety (HP:0000739)1.87644600
108Focal dystonia (HP:0004373)1.87459893
109Overriding aorta (HP:0002623)1.86762164
110Inappropriate behavior (HP:0000719)1.86478660
111Dysmetric saccades (HP:0000641)1.85773921
112Bronchomalacia (HP:0002780)1.85335053
113Abnormal EKG (HP:0003115)1.85140326
114Patellar dislocation (HP:0002999)1.85076062
115Truncal ataxia (HP:0002078)1.84403437
116Abnormality of the phalanges of the hallux (HP:0010057)1.84131175
117Wrist flexion contracture (HP:0001239)1.83907153
118Aortic regurgitation (HP:0001659)1.83599435
119Progressive inability to walk (HP:0002505)1.83471862
120Round ear (HP:0100830)1.82965694
121Aplasia involving bones of the extremities (HP:0009825)1.81558652
122Aplasia involving bones of the upper limbs (HP:0009823)1.81558652
123Aplasia of the phalanges of the hand (HP:0009802)1.81558652
124Hypercortisolism (HP:0001578)1.79497592
125Hyperextensible skin (HP:0000974)1.78081824
126Scapular winging (HP:0003691)1.77817078
127Long palpebral fissure (HP:0000637)1.76971017
128Abnormality of skeletal muscle fiber size (HP:0012084)1.76435457
129Flat acetabular roof (HP:0003180)1.76080469
130Amyotrophic lateral sclerosis (HP:0007354)1.74816889
131Precocious puberty (HP:0000826)1.74172092
132Megalocornea (HP:0000485)1.71727151
133Lower limb muscle weakness (HP:0007340)1.71639552
134Joint laxity (HP:0001388)1.71033292
135Achilles tendon contracture (HP:0001771)1.70977829
136Coronal craniosynostosis (HP:0004440)1.70554117
137Vertebral compression fractures (HP:0002953)1.69466283
138Blue sclerae (HP:0000592)1.69344925
139Hypoventilation (HP:0002791)1.69317881
140Generalized hypotonia (HP:0001290)1.68762725
141Prolonged QT interval (HP:0001657)1.68723597
142Abnormality of ocular smooth pursuit (HP:0000617)1.68398620
143Myotonia (HP:0002486)1.67227186
144Wormian bones (HP:0002645)1.67195652
145Diplopia (HP:0000651)1.66651741
146Abnormality of binocular vision (HP:0011514)1.66651741
147Lower limb asymmetry (HP:0100559)1.66401507
148Infantile muscular hypotonia (HP:0008947)1.65674499
149Cerebral aneurysm (HP:0004944)1.65180540
150Failure to thrive in infancy (HP:0001531)1.64732313
151Myopathic facies (HP:0002058)1.63257756
152Abnormality of the aortic arch (HP:0012303)1.63142344
153Arnold-Chiari malformation (HP:0002308)1.62572542
154Distal lower limb amyotrophy (HP:0008944)1.62475563
155Abnormality of incisor morphology (HP:0011063)1.61111478
156Absent speech (HP:0001344)1.60416725
157Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.60391240
158Aplasia/Hypoplasia of the brainstem (HP:0007362)1.60347035
159Hypoplasia of the brainstem (HP:0002365)1.60347035
160Thin bony cortex (HP:0002753)1.58486707
161Mildly elevated creatine phosphokinase (HP:0008180)1.58233266
162Limb-girdle muscle atrophy (HP:0003797)1.58067089
163Abnormal hair whorl (HP:0010721)1.57417088
164Ulnar deviation of the wrist (HP:0003049)1.57309359
165Broad ribs (HP:0000885)1.55978500
166Craniofacial dystonia (HP:0012179)1.55909206
167Mitral valve prolapse (HP:0001634)1.54671162
168Shawl scrotum (HP:0000049)1.53374402
169Morphological abnormality of the middle ear (HP:0008609)1.53267502
170Overgrowth (HP:0001548)1.51449302

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.19563201
2MARK13.80024187
3EPHA43.60521462
4NTRK33.05901087
5PRKD32.81224395
6DAPK22.73590658
7PAK62.56598639
8MAP3K42.55564498
9MINK12.49370712
10SIK12.27721581
11KSR22.16646017
12TRIB32.09963716
13NTRK22.06436786
14TAOK12.01073111
15CAMKK11.99598054
16KSR11.98754020
17TYRO31.88651459
18CASK1.84441522
19LATS21.83769141
20SIK21.71050880
21MAP2K71.65173400
22STK381.64141139
23ERN11.61025483
24EPHB11.58578514
25MAP2K41.57663281
26CDK51.47558905
27PHKG21.46746697
28PHKG11.46746697
29IRAK31.45388480
30TAOK21.43758888
31RIPK41.43743928
32NTRK11.40727456
33DAPK11.29944312
34RIPK11.28577751
35EPHB21.28036275
36MAPK131.18832388
37EPHA21.11771808
38STK111.11183495
39MAP3K21.09326342
40DYRK1B1.05860583
41DMPK1.05732456
42PRPF4B1.03767766
43PAK21.03007987
44MAP3K121.02229544
45ALK0.99683164
46MARK20.99196816
47FGFR40.95560084
48CDK180.95433618
49RET0.94873874
50FES0.94262723
51CDK150.94249072
52LMTK20.94137511
53ICK0.93652160
54PLK20.92903779
55MYLK0.91420937
56DDR20.90590825
57CDK140.90411464
58MAP3K110.90227601
59PRKCH0.90170727
60PAK30.89161266
61MAP3K130.87957078
62PDGFRA0.87399540
63CAMK10.86827800
64MTOR0.85828299
65EEF2K0.85653540
66UHMK10.85053437
67PTK2B0.84892222
68CDK11A0.84351353
69CDK190.82212624
70RPS6KA20.82164537
71ARAF0.81842596
72STK30.81750292
73GRK50.81588981
74PRKCG0.81423486
75MOS0.77344364
76CDK120.77200880
77PDGFRB0.72994221
78NEK10.72779763
79DAPK30.71962243
80PKN20.69180049
81PRKCZ0.68754893
82FER0.68549264
83ROCK20.68082045
84CDC42BPA0.66618940
85MAP3K70.64736436
86PINK10.62083970
87CAMK2A0.61557028
88CAMK1G0.59554309
89ABL20.59516892
90PNCK0.59106176
91SGK30.58958332
92BRAF0.57886577
93DYRK1A0.57671750
94CAMK40.57452730
95ROCK10.56914026
96TESK10.56535572
97BMX0.56289112
98RAF10.55978279
99PTK60.55366218
100PKN10.54802550
101CAMK2G0.54549268
102LIMK10.54540108
103PIM20.54281740
104MAP2K10.54139718
105PDPK10.53862421
106CAMK1D0.52457458
107PDK10.51808974
108SGK2230.51048958
109SGK4940.51048958
110CAMKK20.50668174
111MAPK120.50313798
112PRKD20.50234405
113TTN0.49472038
114CAMK2B0.48513399
115MAP3K10.47446849
116RPS6KL10.45829126
117RPS6KC10.45829126
118PTK20.45557873
119FYN0.44061716
120PAK40.44010685
121* RPS6KA30.43278822
122DYRK20.43250831
123HIPK20.42091606
124DYRK30.42055509
125PRKD10.41692778
126ERBB20.40858670
127MAP3K100.40581773
128* SGK10.40018337
129ERBB30.39577658
130MAPK100.39461540
131CSNK1G20.38988887
132SGK20.37594813
133MAP3K60.35952728

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.57977268
2Nicotine addiction_Homo sapiens_hsa050332.36928222
3Olfactory transduction_Homo sapiens_hsa047402.27162870
4Circadian entrainment_Homo sapiens_hsa047132.16734150
5Long-term potentiation_Homo sapiens_hsa047202.12512872
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.04590789
7Glutamatergic synapse_Homo sapiens_hsa047242.01633556
8Notch signaling pathway_Homo sapiens_hsa043302.00703567
9GABAergic synapse_Homo sapiens_hsa047271.89173548
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.86153262
11Morphine addiction_Homo sapiens_hsa050321.82115649
12Amphetamine addiction_Homo sapiens_hsa050311.82022993
13Cholinergic synapse_Homo sapiens_hsa047251.74238615
14Dopaminergic synapse_Homo sapiens_hsa047281.74044506
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72693132
16Salivary secretion_Homo sapiens_hsa049701.69374493
17Oxytocin signaling pathway_Homo sapiens_hsa049211.68467687
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67211133
19Gastric acid secretion_Homo sapiens_hsa049711.63370766
20GnRH signaling pathway_Homo sapiens_hsa049121.59472421
21Insulin secretion_Homo sapiens_hsa049111.58300693
22ECM-receptor interaction_Homo sapiens_hsa045121.55883635
23Gap junction_Homo sapiens_hsa045401.49546833
24Glioma_Homo sapiens_hsa052141.43485599
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37084195
26Long-term depression_Homo sapiens_hsa047301.35928552
27Dilated cardiomyopathy_Homo sapiens_hsa054141.35219592
28Renin secretion_Homo sapiens_hsa049241.33642754
29Cocaine addiction_Homo sapiens_hsa050301.33514762
30Axon guidance_Homo sapiens_hsa043601.32972611
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27023786
32Estrogen signaling pathway_Homo sapiens_hsa049151.26973661
33Type II diabetes mellitus_Homo sapiens_hsa049301.25891631
34Calcium signaling pathway_Homo sapiens_hsa040201.25750395
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21969618
36ErbB signaling pathway_Homo sapiens_hsa040121.20823335
37Adherens junction_Homo sapiens_hsa045201.19125866
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18924700
39cAMP signaling pathway_Homo sapiens_hsa040241.15009450
40Melanogenesis_Homo sapiens_hsa049161.13920886
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.12640151
42VEGF signaling pathway_Homo sapiens_hsa043701.11841593
43Taste transduction_Homo sapiens_hsa047421.10640428
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09054698
45Serotonergic synapse_Homo sapiens_hsa047261.08394158
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04126945
47mTOR signaling pathway_Homo sapiens_hsa041501.03720174
48Dorso-ventral axis formation_Homo sapiens_hsa043201.02868224
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.01566477
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.99739383
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99476244
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99405398
53Endometrial cancer_Homo sapiens_hsa052130.99101882
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97681466
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95606416
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.94823349
57Basal cell carcinoma_Homo sapiens_hsa052170.93948231
58AMPK signaling pathway_Homo sapiens_hsa041520.93474968
59Oocyte meiosis_Homo sapiens_hsa041140.92560716
60MAPK signaling pathway_Homo sapiens_hsa040100.91803482
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.89169480
62Bladder cancer_Homo sapiens_hsa052190.87222187
63Choline metabolism in cancer_Homo sapiens_hsa052310.84548997
64Cardiac muscle contraction_Homo sapiens_hsa042600.84329322
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83990915
66Renal cell carcinoma_Homo sapiens_hsa052110.83666378
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83618447
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81972926
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81017928
70Protein digestion and absorption_Homo sapiens_hsa049740.80698065
71Rap1 signaling pathway_Homo sapiens_hsa040150.80255459
72Colorectal cancer_Homo sapiens_hsa052100.80145606
73Endocytosis_Homo sapiens_hsa041440.79433665
74Non-small cell lung cancer_Homo sapiens_hsa052230.78986670
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78139907
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77897096
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73425283
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72479488
79Insulin signaling pathway_Homo sapiens_hsa049100.70772667
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69451102
81Hippo signaling pathway_Homo sapiens_hsa043900.68693339
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.68599756
83Ras signaling pathway_Homo sapiens_hsa040140.68528052
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67501945
85Proteoglycans in cancer_Homo sapiens_hsa052050.67501869
86Wnt signaling pathway_Homo sapiens_hsa043100.66001744
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65011622
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64897032
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64790271
90Focal adhesion_Homo sapiens_hsa045100.64608074
91Collecting duct acid secretion_Homo sapiens_hsa049660.64250139
92Prolactin signaling pathway_Homo sapiens_hsa049170.63894240
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62547629
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61711978
95Chronic myeloid leukemia_Homo sapiens_hsa052200.61246900
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60869337
97Chemokine signaling pathway_Homo sapiens_hsa040620.60530604
98Tight junction_Homo sapiens_hsa045300.59691089
99Lysosome_Homo sapiens_hsa041420.59415217
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58331911
101Salmonella infection_Homo sapiens_hsa051320.57903370
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57620008
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57440717
104Hedgehog signaling pathway_Homo sapiens_hsa043400.56668225
105Other glycan degradation_Homo sapiens_hsa005110.56289624
106Pancreatic secretion_Homo sapiens_hsa049720.56084656
107Pathways in cancer_Homo sapiens_hsa052000.56011239
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54994353
109Platelet activation_Homo sapiens_hsa046110.54352912
110Glucagon signaling pathway_Homo sapiens_hsa049220.54201403
111Prion diseases_Homo sapiens_hsa050200.54162141
112MicroRNAs in cancer_Homo sapiens_hsa052060.53621297
113Amoebiasis_Homo sapiens_hsa051460.53405759
114Thyroid hormone synthesis_Homo sapiens_hsa049180.52671694
115Bile secretion_Homo sapiens_hsa049760.52200625
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49632408
117Vibrio cholerae infection_Homo sapiens_hsa051100.48476542
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47728314
119Pancreatic cancer_Homo sapiens_hsa052120.47544984

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