

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | protein localization to kinetochore (GO:0034501) | 5.36865620 |
| 2 | mitotic sister chromatid segregation (GO:0000070) | 4.95554498 |
| 3 | mitotic metaphase plate congression (GO:0007080) | 4.94269982 |
| 4 | kinetochore organization (GO:0051383) | 4.88560099 |
| 5 | protein localization to chromosome, centromeric region (GO:0071459) | 4.75627832 |
| 6 | DNA unwinding involved in DNA replication (GO:0006268) | 4.71403419 |
| 7 | sister chromatid segregation (GO:0000819) | 4.70773887 |
| 8 | nuclear pore organization (GO:0006999) | 4.67280797 |
| 9 | mitotic chromosome condensation (GO:0007076) | 4.58799068 |
| 10 | establishment of integrated proviral latency (GO:0075713) | 4.54936605 |
| 11 | nuclear pore complex assembly (GO:0051292) | 4.54422740 |
| 12 | metaphase plate congression (GO:0051310) | 4.45108374 |
| 13 | DNA ligation (GO:0006266) | 4.38134252 |
| 14 | DNA replication initiation (GO:0006270) | 4.36813353 |
| 15 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.36186470 |
| 16 | mitotic nuclear envelope disassembly (GO:0007077) | 4.35327932 |
| 17 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 4.31746980 |
| 18 | kinetochore assembly (GO:0051382) | 4.30308642 |
| 19 | regulation of spindle organization (GO:0090224) | 4.29406601 |
| 20 | CENP-A containing nucleosome assembly (GO:0034080) | 4.26731365 |
| 21 | attachment of spindle microtubules to kinetochore (GO:0008608) | 4.26717871 |
| 22 | chromatin remodeling at centromere (GO:0031055) | 4.24651967 |
| 23 | regulation of DNA methylation (GO:0044030) | 4.22291813 |
| 24 | DNA strand elongation (GO:0022616) | 4.15377523 |
| 25 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.09566779 |
| 26 | DNA replication checkpoint (GO:0000076) | 4.09214025 |
| 27 | membrane disassembly (GO:0030397) | 4.03566383 |
| 28 | nuclear envelope disassembly (GO:0051081) | 4.03566383 |
| 29 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.03060969 |
| 30 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.03060969 |
| 31 | * establishment of chromosome localization (GO:0051303) | 3.96888236 |
| 32 | DNA replication-independent nucleosome organization (GO:0034724) | 3.91148252 |
| 33 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.91148252 |
| 34 | regulation of mitotic spindle organization (GO:0060236) | 3.89978148 |
| 35 | mitotic recombination (GO:0006312) | 3.87848263 |
| 36 | meiotic chromosome segregation (GO:0045132) | 3.87005090 |
| 37 | regulation of meiosis I (GO:0060631) | 3.85977657 |
| 38 | telomere maintenance via recombination (GO:0000722) | 3.82604243 |
| 39 | centriole replication (GO:0007099) | 3.74906353 |
| 40 | spindle checkpoint (GO:0031577) | 3.72477763 |
| 41 | mitotic G2/M transition checkpoint (GO:0044818) | 3.71012150 |
| 42 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.70839588 |
| 43 | synapsis (GO:0007129) | 3.64667634 |
| 44 | histone exchange (GO:0043486) | 3.61847856 |
| 45 | negative regulation of mitosis (GO:0045839) | 3.61297779 |
| 46 | spindle assembly checkpoint (GO:0071173) | 3.60621550 |
| 47 | negative regulation of chromosome segregation (GO:0051985) | 3.59750033 |
| 48 | * regulation of chromosome segregation (GO:0051983) | 3.55485378 |
| 49 | protein localization to chromosome (GO:0034502) | 3.55432035 |
| 50 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.54023788 |
| 51 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.54023788 |
| 52 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.54023788 |
| 53 | negative regulation of sister chromatid segregation (GO:0033046) | 3.54023788 |
| 54 | DNA geometric change (GO:0032392) | 3.52901066 |
| 55 | DNA duplex unwinding (GO:0032508) | 3.52585570 |
| 56 | pore complex assembly (GO:0046931) | 3.51881574 |
| 57 | protein K6-linked ubiquitination (GO:0085020) | 3.49943859 |
| 58 | chromosome segregation (GO:0007059) | 3.49746464 |
| 59 | mitotic spindle assembly checkpoint (GO:0007094) | 3.49702097 |
| 60 | regulation of histone H3-K9 methylation (GO:0051570) | 3.48172100 |
| 61 | regulation of spindle checkpoint (GO:0090231) | 3.48148234 |
| 62 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.47646319 |
| 63 | mitotic spindle checkpoint (GO:0071174) | 3.46488732 |
| 64 | regulation of centrosome cycle (GO:0046605) | 3.46428296 |
| 65 | mitotic sister chromatid cohesion (GO:0007064) | 3.46423564 |
| 66 | telomere maintenance via telomere lengthening (GO:0010833) | 3.46277978 |
| 67 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.46254314 |
| 68 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.44302292 |
| 69 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.44302292 |
| 70 | meiotic cell cycle (GO:0051321) | 3.41677231 |
| 71 | DNA packaging (GO:0006323) | 3.41343744 |
| 72 | chromatin assembly or disassembly (GO:0006333) | 3.40658439 |
| 73 | * regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.40532042 |
| 74 | positive regulation of histone H3-K4 methylation (GO:0051571) | 3.39780835 |
| 75 | IMP biosynthetic process (GO:0006188) | 3.38658084 |
| 76 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.38313769 |
| 77 | histone-serine phosphorylation (GO:0035404) | 3.36963090 |
| 78 | establishment of viral latency (GO:0019043) | 3.36659051 |
| 79 | formation of translation preinitiation complex (GO:0001731) | 3.35700015 |
| 80 | * regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.34702498 |
| 81 | regulation of centriole replication (GO:0046599) | 3.33553134 |
| 82 | regulation of DNA endoreduplication (GO:0032875) | 3.32576111 |
| 83 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.31987686 |
| 84 | * positive regulation of chromosome segregation (GO:0051984) | 3.30651795 |
| 85 | regulation of sister chromatid cohesion (GO:0007063) | 3.29798747 |
| 86 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.29661081 |
| 87 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.29661081 |
| 88 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.29361551 |
| 89 | spindle assembly involved in mitosis (GO:0090307) | 3.28860530 |
| 90 | mitotic spindle organization (GO:0007052) | 3.26575787 |
| 91 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.24049308 |
| 92 | * regulation of sister chromatid segregation (GO:0033045) | 3.24024377 |
| 93 | * regulation of mitotic sister chromatid separation (GO:0010965) | 3.24024377 |
| 94 | * regulation of mitotic sister chromatid segregation (GO:0033047) | 3.24024377 |
| 95 | negative regulation of nuclear division (GO:0051784) | 3.22115824 |
| 96 | nucleobase biosynthetic process (GO:0046112) | 3.20262550 |
| 97 | microtubule depolymerization (GO:0007019) | 3.19088405 |
| 98 | ventricular cardiac muscle cell development (GO:0055015) | 3.16667424 |
| 99 | chromosome condensation (GO:0030261) | 3.15014309 |
| 100 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.14154061 |
| 101 | DNA conformation change (GO:0071103) | 3.13831611 |
| 102 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435) | 3.13417033 |
| 103 | ATP-dependent chromatin remodeling (GO:0043044) | 3.11893218 |
| 104 | DNA topological change (GO:0006265) | 3.11477673 |
| 105 | regulation of helicase activity (GO:0051095) | 3.10292461 |
| 106 | negative regulation of cell division (GO:0051782) | 3.08448693 |
| 107 | nuclear envelope organization (GO:0006998) | 3.08288332 |
| 108 | mitotic nuclear division (GO:0007067) | 3.06971702 |
| 109 | negative regulation of histone methylation (GO:0031061) | 3.06372345 |
| 110 | mismatch repair (GO:0006298) | 3.05141901 |
| 111 | mitotic G2 DNA damage checkpoint (GO:0007095) | 3.03684007 |
| 112 | chromosome organization (GO:0051276) | 3.01079866 |
| 113 | chromosome organization involved in meiosis (GO:0070192) | 3.00998200 |
| 114 | non-recombinational repair (GO:0000726) | 2.99710819 |
| 115 | ribosomal small subunit assembly (GO:0000028) | 2.99689537 |
| 116 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 2.99596428 |
| 117 | telomere maintenance (GO:0000723) | 2.98705767 |
| 118 | maturation of SSU-rRNA (GO:0030490) | 2.98210364 |
| 119 | regulation of telomere maintenance via telomerase (GO:0032210) | 2.97945565 |
| 120 | telomere organization (GO:0032200) | 2.96399157 |
| 121 | IMP metabolic process (GO:0046040) | 2.96290268 |
| 122 | mitotic cell cycle (GO:0000278) | 2.94204050 |
| 123 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.93445237 |
| 124 | purine nucleobase biosynthetic process (GO:0009113) | 2.93047173 |
| 125 | regulation of posttranscriptional gene silencing (GO:0060147) | 2.92313787 |
| 126 | regulation of gene silencing by miRNA (GO:0060964) | 2.92313787 |
| 127 | regulation of gene silencing by RNA (GO:0060966) | 2.92313787 |
| 128 | ribosome assembly (GO:0042255) | 2.91113651 |
| 129 | * positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 2.90483582 |
| 130 | * positive regulation of mitotic sister chromatid separation (GO:1901970) | 2.90483582 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * FOXM1_23109430_ChIP-Seq_U2OS_Human | 6.24364189 |
| 2 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.50881261 |
| 3 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.98405488 |
| 4 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.73243827 |
| 5 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.03992347 |
| 6 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.73266895 |
| 7 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.57738372 |
| 8 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.49589464 |
| 9 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.46707603 |
| 10 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.41685646 |
| 11 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.40245193 |
| 12 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.32292343 |
| 13 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.30517026 |
| 14 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.28158839 |
| 15 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.27085634 |
| 16 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.26299665 |
| 17 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.24409134 |
| 18 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.03425007 |
| 19 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.02463012 |
| 20 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.02380455 |
| 21 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.01503162 |
| 22 | E2F7_22180533_ChIP-Seq_HELA_Human | 10.1303380 |
| 23 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.92930412 |
| 24 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.91176260 |
| 25 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.91006235 |
| 26 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.87209554 |
| 27 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.85764067 |
| 28 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.79560297 |
| 29 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.72015950 |
| 30 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.71646365 |
| 31 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.71123665 |
| 32 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.69517365 |
| 33 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.68231574 |
| 34 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.62184280 |
| 35 | MYC_22102868_ChIP-Seq_BL_Human | 1.59086830 |
| 36 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.57594099 |
| 37 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.57509437 |
| 38 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.56002983 |
| 39 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.55857218 |
| 40 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.55815676 |
| 41 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.55335400 |
| 42 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.53560765 |
| 43 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.49847344 |
| 44 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.48766984 |
| 45 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.47887976 |
| 46 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.46493244 |
| 47 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.46198655 |
| 48 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.44360113 |
| 49 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.44273613 |
| 50 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.42948658 |
| 51 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.38351129 |
| 52 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.37907739 |
| 53 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.37316499 |
| 54 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.37094039 |
| 55 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.36709773 |
| 56 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.36215478 |
| 57 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.33537253 |
| 58 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.31191005 |
| 59 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.30506892 |
| 60 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.26011204 |
| 61 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.25637586 |
| 62 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.24939728 |
| 63 | EWS_26573619_Chip-Seq_HEK293_Human | 1.24183520 |
| 64 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.23555484 |
| 65 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.22791834 |
| 66 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.21457783 |
| 67 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.16284037 |
| 68 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.14813050 |
| 69 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.14069731 |
| 70 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.12703415 |
| 71 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.12198954 |
| 72 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.12198954 |
| 73 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.12198954 |
| 74 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.10745644 |
| 75 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.10349247 |
| 76 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.10243680 |
| 77 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.09665593 |
| 78 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.08563003 |
| 79 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.08100731 |
| 80 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.06705821 |
| 81 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.05943658 |
| 82 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.02636207 |
| 83 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.02625898 |
| 84 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.01404933 |
| 85 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.01178563 |
| 86 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.96610563 |
| 87 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.95175113 |
| 88 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.95022745 |
| 89 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.91631993 |
| 90 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.91148055 |
| 91 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.91129944 |
| 92 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.90956692 |
| 93 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.90670726 |
| 94 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.90488187 |
| 95 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.90354858 |
| 96 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.89757975 |
| 97 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.89236440 |
| 98 | FUS_26573619_Chip-Seq_HEK293_Human | 0.89055774 |
| 99 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.88684106 |
| 100 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.86694527 |
| 101 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.86647605 |
| 102 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.86637576 |
| 103 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.86556602 |
| 104 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.85445576 |
| 105 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.84976808 |
| 106 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.83872249 |
| 107 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.83745906 |
| 108 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.83550667 |
| 109 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.82257075 |
| 110 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.81579455 |
| 111 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.80482079 |
| 112 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 0.80295341 |
| 113 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.79418678 |
| 114 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.67978230 |
| 115 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 0.64932364 |
| 116 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.62499346 |
| 117 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.61118494 |
| 118 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.59355164 |
| 119 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 0.57719433 |
| 120 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.57212402 |
| 121 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.56212645 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.06921095 |
| 2 | MP0010094_abnormal_chromosome_stability | 4.83792454 |
| 3 | MP0003111_abnormal_nucleus_morphology | 4.82393299 |
| 4 | MP0003077_abnormal_cell_cycle | 4.16202534 |
| 5 | MP0008057_abnormal_DNA_replication | 4.14909914 |
| 6 | MP0004957_abnormal_blastocyst_morpholog | 4.02401890 |
| 7 | MP0008058_abnormal_DNA_repair | 3.20704545 |
| 8 | MP0008007_abnormal_cellular_replicative | 2.81885535 |
| 9 | MP0008932_abnormal_embryonic_tissue | 2.52419070 |
| 10 | MP0010307_abnormal_tumor_latency | 2.35130971 |
| 11 | MP0010352_gastrointestinal_tract_polyps | 2.32922191 |
| 12 | MP0000350_abnormal_cell_proliferation | 2.29345672 |
| 13 | MP0001730_embryonic_growth_arrest | 2.27468199 |
| 14 | MP0002396_abnormal_hematopoietic_system | 2.10147279 |
| 15 | MP0003123_paternal_imprinting | 2.05392638 |
| 16 | MP0008877_abnormal_DNA_methylation | 2.01790096 |
| 17 | MP0005499_abnormal_olfactory_system | 1.99883382 |
| 18 | MP0005394_taste/olfaction_phenotype | 1.99883382 |
| 19 | MP0005380_embryogenesis_phenotype | 1.83629802 |
| 20 | MP0001672_abnormal_embryogenesis/_devel | 1.83629802 |
| 21 | MP0005076_abnormal_cell_differentiation | 1.78141077 |
| 22 | MP0003786_premature_aging | 1.76246863 |
| 23 | MP0001697_abnormal_embryo_size | 1.75715845 |
| 24 | MP0009697_abnormal_copulation | 1.71116273 |
| 25 | MP0002085_abnormal_embryonic_tissue | 1.66252661 |
| 26 | MP0000490_abnormal_crypts_of | 1.62030025 |
| 27 | MP0003121_genomic_imprinting | 1.61528081 |
| 28 | MP0003984_embryonic_growth_retardation | 1.60210360 |
| 29 | MP0005395_other_phenotype | 1.59700795 |
| 30 | MP0002084_abnormal_developmental_patter | 1.58826540 |
| 31 | MP0002088_abnormal_embryonic_growth/wei | 1.56865576 |
| 32 | MP0002080_prenatal_lethality | 1.53970415 |
| 33 | MP0004197_abnormal_fetal_growth/weight/ | 1.53365840 |
| 34 | * MP0002086_abnormal_extraembryonic_tissu | 1.51250785 |
| 35 | MP0004808_abnormal_hematopoietic_stem | 1.47035819 |
| 36 | MP0009379_abnormal_foot_pigmentation | 1.46969093 |
| 37 | MP0000313_abnormal_cell_death | 1.43785645 |
| 38 | MP0002019_abnormal_tumor_incidence | 1.40275438 |
| 39 | MP0003718_maternal_effect | 1.39018845 |
| 40 | MP0002234_abnormal_pharynx_morphology | 1.38246781 |
| 41 | MP0003890_abnormal_embryonic-extraembry | 1.35743459 |
| 42 | MP0010030_abnormal_orbit_morphology | 1.34673698 |
| 43 | MP0003567_abnormal_fetal_cardiomyocyte | 1.32267290 |
| 44 | * MP0003699_abnormal_female_reproductive | 1.21466972 |
| 45 | MP0001293_anophthalmia | 1.21080901 |
| 46 | MP0002233_abnormal_nose_morphology | 1.19620755 |
| 47 | MP0010234_abnormal_vibrissa_follicle | 1.16243385 |
| 48 | MP0002210_abnormal_sex_determination | 1.14713678 |
| 49 | MP0005397_hematopoietic_system_phenotyp | 1.14276348 |
| 50 | MP0001545_abnormal_hematopoietic_system | 1.14276348 |
| 51 | MP0000703_abnormal_thymus_morphology | 1.10559153 |
| 52 | MP0003941_abnormal_skin_development | 1.09550637 |
| 53 | MP0006292_abnormal_olfactory_placode | 1.08965125 |
| 54 | MP0000566_synostosis | 1.08448408 |
| 55 | MP0002398_abnormal_bone_marrow | 1.02158388 |
| 56 | MP0003705_abnormal_hypodermis_morpholog | 1.02154122 |
| 57 | MP0004133_heterotaxia | 1.01104058 |
| 58 | MP0003566_abnormal_cell_adhesion | 0.99722363 |
| 59 | MP0001188_hyperpigmentation | 0.99527618 |
| 60 | * MP0002161_abnormal_fertility/fecundity | 0.97276808 |
| 61 | MP0001145_abnormal_male_reproductive | 0.96855520 |
| 62 | MP0003763_abnormal_thymus_physiology | 0.95647355 |
| 63 | MP0003937_abnormal_limbs/digits/tail_de | 0.94279832 |
| 64 | MP0009278_abnormal_bone_marrow | 0.94231316 |
| 65 | MP0002722_abnormal_immune_system | 0.94004413 |
| 66 | MP0009053_abnormal_anal_canal | 0.93956531 |
| 67 | MP0005023_abnormal_wound_healing | 0.92865350 |
| 68 | MP0002111_abnormal_tail_morphology | 0.88908858 |
| 69 | MP0001929_abnormal_gametogenesis | 0.88861843 |
| 70 | MP0009333_abnormal_splenocyte_physiolog | 0.88659204 |
| 71 | MP0000762_abnormal_tongue_morphology | 0.87891743 |
| 72 | MP0003315_abnormal_perineum_morphology | 0.87718975 |
| 73 | MP0000858_altered_metastatic_potential | 0.86635509 |
| 74 | MP0000689_abnormal_spleen_morphology | 0.86393321 |
| 75 | MP0002877_abnormal_melanocyte_morpholog | 0.86332538 |
| 76 | MP0003698_abnormal_male_reproductive | 0.85798236 |
| 77 | MP0003119_abnormal_digestive_system | 0.85551431 |
| 78 | MP0000049_abnormal_middle_ear | 0.85236786 |
| 79 | MP0001915_intracranial_hemorrhage | 0.85073856 |
| 80 | MP0000653_abnormal_sex_gland | 0.84641364 |
| 81 | MP0009672_abnormal_birth_weight | 0.84077066 |
| 82 | MP0001119_abnormal_female_reproductive | 0.84023148 |
| 83 | MP0005621_abnormal_cell_physiology | 0.83678424 |
| 84 | MP0003136_yellow_coat_color | 0.83178244 |
| 85 | MP0000537_abnormal_urethra_morphology | 0.82404704 |
| 86 | MP0005384_cellular_phenotype | 0.82275252 |
| 87 | MP0002938_white_spotting | 0.81296573 |
| 88 | MP0009703_decreased_birth_body | 0.81159328 |
| 89 | MP0004264_abnormal_extraembryonic_tissu | 0.80578776 |
| 90 | MP0003950_abnormal_plasma_membrane | 0.78682212 |
| 91 | MP0003861_abnormal_nervous_system | 0.78573280 |
| 92 | MP0001286_abnormal_eye_development | 0.77270298 |
| 93 | MP0003755_abnormal_palate_morphology | 0.76121271 |
| 94 | MP0002429_abnormal_blood_cell | 0.74819300 |
| 95 | MP0002653_abnormal_ependyma_morphology | 0.74068244 |
| 96 | MP0000647_abnormal_sebaceous_gland | 0.72703045 |
| 97 | MP0000569_abnormal_digit_pigmentation | 0.71981355 |
| 98 | MP0006054_spinal_hemorrhage | 0.71819922 |
| 99 | MP0003787_abnormal_imprinting | 0.71459688 |
| 100 | MP0005389_reproductive_system_phenotype | 0.70273768 |
| 101 | MP0002092_abnormal_eye_morphology | 0.69909061 |
| 102 | MP0006072_abnormal_retinal_apoptosis | 0.69851440 |
| 103 | MP0002102_abnormal_ear_morphology | 0.69316007 |
| 104 | MP0006035_abnormal_mitochondrial_morpho | 0.68833858 |
| 105 | MP0000432_abnormal_head_morphology | 0.68714580 |
| 106 | MP0002160_abnormal_reproductive_system | 0.68674070 |
| 107 | MP0001529_abnormal_vocalization | 0.67659512 |
| 108 | MP0003448_altered_tumor_morphology | 0.66218090 |
| 109 | MP0002697_abnormal_eye_size | 0.66055863 |
| 110 | MP0003806_abnormal_nucleotide_metabolis | 0.65788059 |
| 111 | MP0002075_abnormal_coat/hair_pigmentati | 0.65550187 |
| 112 | MP0000428_abnormal_craniofacial_morphol | 0.65366945 |
| 113 | MP0002925_abnormal_cardiovascular_devel | 0.64639967 |
| 114 | MP0002751_abnormal_autonomic_nervous | 0.63934888 |
| 115 | MP0005501_abnormal_skin_physiology | 0.63432506 |
| 116 | MP0001849_ear_inflammation | 0.63312502 |
| 117 | MP0002796_impaired_skin_barrier | 0.63132924 |
| 118 | MP0010678_abnormal_skin_adnexa | 0.62430578 |
| 119 | MP0000371_diluted_coat_color | 0.62020904 |
| 120 | MP0005187_abnormal_penis_morphology | 0.61482340 |
| 121 | MP0000716_abnormal_immune_system | 0.61347620 |
| 122 | MP0000733_abnormal_muscle_development | 0.60990935 |
| 123 | MP0000358_abnormal_cell_content/ | 0.59269190 |
| 124 | MP0003935_abnormal_craniofacial_develop | 0.58959945 |
| 125 | MP0002132_abnormal_respiratory_system | 0.58827631 |
| 126 | MP0001186_pigmentation_phenotype | 0.57574943 |
| 127 | MP0000477_abnormal_intestine_morphology | 0.57525955 |
| 128 | MP0002095_abnormal_skin_pigmentation | 0.57432027 |
| 129 | MP0001346_abnormal_lacrimal_gland | 0.56689191 |
| 130 | MP0000631_abnormal_neuroendocrine_gland | 0.55524185 |
| 131 | MP0001919_abnormal_reproductive_system | 0.55329583 |
| 132 | MP0005410_abnormal_fertilization | 0.55075440 |
| 133 | MP0008789_abnormal_olfactory_epithelium | 0.53358132 |
| 134 | MP0005391_vision/eye_phenotype | 0.52434926 |
| 135 | MP0002177_abnormal_outer_ear | 0.50553517 |
| 136 | MP0002114_abnormal_axial_skeleton | 0.46588276 |
| 137 | MP0009250_abnormal_appendicular_skeleto | 0.45691529 |
| 138 | MP0002081_perinatal_lethality | 0.44827460 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Chromsome breakage (HP:0040012) | 5.16784467 |
| 2 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 4.95852372 |
| 3 | Birth length less than 3rd percentile (HP:0003561) | 4.05153538 |
| 4 | Abnormality of chromosome stability (HP:0003220) | 3.68226961 |
| 5 | Reticulocytopenia (HP:0001896) | 3.58759419 |
| 6 | Cortical dysplasia (HP:0002539) | 3.57595834 |
| 7 | Meckel diverticulum (HP:0002245) | 3.47881516 |
| 8 | Medulloblastoma (HP:0002885) | 3.39915440 |
| 9 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.33526893 |
| 10 | Abnormality of the ileum (HP:0001549) | 3.32615592 |
| 11 | Ependymoma (HP:0002888) | 3.31110333 |
| 12 | Abnormality of the preputium (HP:0100587) | 3.27831932 |
| 13 | Breast hypoplasia (HP:0003187) | 3.23835956 |
| 14 | Septo-optic dysplasia (HP:0100842) | 3.21556479 |
| 15 | Patellar aplasia (HP:0006443) | 3.20229787 |
| 16 | Selective tooth agenesis (HP:0001592) | 3.12005556 |
| 17 | Duodenal stenosis (HP:0100867) | 3.07577164 |
| 18 | Small intestinal stenosis (HP:0012848) | 3.07577164 |
| 19 | Impulsivity (HP:0100710) | 3.05477399 |
| 20 | Agnosia (HP:0010524) | 3.03634416 |
| 21 | Colon cancer (HP:0003003) | 3.00940260 |
| 22 | Myelodysplasia (HP:0002863) | 2.97585757 |
| 23 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.97124641 |
| 24 | Volvulus (HP:0002580) | 2.96499078 |
| 25 | Ectopic kidney (HP:0000086) | 2.91382924 |
| 26 | Absent radius (HP:0003974) | 2.86253773 |
| 27 | Increased nuchal translucency (HP:0010880) | 2.84271072 |
| 28 | Rhabdomyosarcoma (HP:0002859) | 2.78460546 |
| 29 | Absent septum pellucidum (HP:0001331) | 2.77963552 |
| 30 | Oligodactyly (hands) (HP:0001180) | 2.75824990 |
| 31 | Abnormality of the septum pellucidum (HP:0007375) | 2.72408531 |
| 32 | Duplicated collecting system (HP:0000081) | 2.66151045 |
| 33 | Aplasia involving forearm bones (HP:0009822) | 2.65626422 |
| 34 | Absent forearm bone (HP:0003953) | 2.65626422 |
| 35 | Absent thumb (HP:0009777) | 2.64757420 |
| 36 | Abnormality of the labia minora (HP:0012880) | 2.64339645 |
| 37 | Sloping forehead (HP:0000340) | 2.61432035 |
| 38 | Abnormality of the duodenum (HP:0002246) | 2.57003245 |
| 39 | 11 pairs of ribs (HP:0000878) | 2.55017953 |
| 40 | Abnormality of the anterior horn cell (HP:0006802) | 2.53831520 |
| 41 | Degeneration of anterior horn cells (HP:0002398) | 2.53831520 |
| 42 | Abnormal lung lobation (HP:0002101) | 2.49414548 |
| 43 | Papillary thyroid carcinoma (HP:0002895) | 2.45980863 |
| 44 | Deviation of the thumb (HP:0009603) | 2.45918375 |
| 45 | Median cleft lip (HP:0000161) | 2.45625072 |
| 46 | Carpal bone hypoplasia (HP:0001498) | 2.44587477 |
| 47 | Abnormality of the carotid arteries (HP:0005344) | 2.43047566 |
| 48 | Proximal placement of thumb (HP:0009623) | 2.42991922 |
| 49 | Embryonal neoplasm (HP:0002898) | 2.42047810 |
| 50 | Bone marrow hypocellularity (HP:0005528) | 2.41242997 |
| 51 | Oral leukoplakia (HP:0002745) | 2.40851921 |
| 52 | Abnormality of the renal collecting system (HP:0004742) | 2.39240186 |
| 53 | Cholecystitis (HP:0001082) | 2.37359016 |
| 54 | Abnormal gallbladder physiology (HP:0012438) | 2.37359016 |
| 55 | Capillary hemangiomas (HP:0005306) | 2.35278036 |
| 56 | Neoplasm of the oral cavity (HP:0100649) | 2.35091276 |
| 57 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.34266090 |
| 58 | Astrocytoma (HP:0009592) | 2.33144038 |
| 59 | Abnormality of the astrocytes (HP:0100707) | 2.33144038 |
| 60 | Abnormality of chromosome segregation (HP:0002916) | 2.32218964 |
| 61 | Glioma (HP:0009733) | 2.31327083 |
| 62 | Amaurosis fugax (HP:0100576) | 2.30243022 |
| 63 | Supernumerary spleens (HP:0009799) | 2.29260011 |
| 64 | Abnormal number of incisors (HP:0011064) | 2.28170171 |
| 65 | Basal cell carcinoma (HP:0002671) | 2.27295065 |
| 66 | Cafe-au-lait spot (HP:0000957) | 2.27256722 |
| 67 | Oligodactyly (HP:0012165) | 2.25771779 |
| 68 | Clubbing of toes (HP:0100760) | 2.22813480 |
| 69 | Tracheoesophageal fistula (HP:0002575) | 2.20802896 |
| 70 | Missing ribs (HP:0000921) | 2.19736301 |
| 71 | Neoplasm of the pancreas (HP:0002894) | 2.19142020 |
| 72 | Embryonal renal neoplasm (HP:0011794) | 2.19050011 |
| 73 | Short thumb (HP:0009778) | 2.17162810 |
| 74 | Arteriovenous malformation (HP:0100026) | 2.12836163 |
| 75 | Gonadotropin excess (HP:0000837) | 2.09754454 |
| 76 | Aplastic anemia (HP:0001915) | 2.09599212 |
| 77 | Choanal atresia (HP:0000453) | 2.09598780 |
| 78 | Atresia of the external auditory canal (HP:0000413) | 2.09009117 |
| 79 | Short 4th metacarpal (HP:0010044) | 2.08361498 |
| 80 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.08361498 |
| 81 | High pitched voice (HP:0001620) | 2.08097919 |
| 82 | Multiple enchondromatosis (HP:0005701) | 2.07660755 |
| 83 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.07382410 |
| 84 | Prominent nose (HP:0000448) | 2.06144408 |
| 85 | Abnormality of DNA repair (HP:0003254) | 2.05346552 |
| 86 | Neoplasm of striated muscle (HP:0009728) | 2.05052648 |
| 87 | Premature graying of hair (HP:0002216) | 2.04794924 |
| 88 | Triphalangeal thumb (HP:0001199) | 2.02658877 |
| 89 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.98888421 |
| 90 | Neoplasm of the colon (HP:0100273) | 1.98597805 |
| 91 | Abnormality of abdominal situs (HP:0011620) | 1.97295250 |
| 92 | Abdominal situs inversus (HP:0003363) | 1.97295250 |
| 93 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.95951245 |
| 94 | Horseshoe kidney (HP:0000085) | 1.95797689 |
| 95 | Maternal diabetes (HP:0009800) | 1.94957806 |
| 96 | Rough bone trabeculation (HP:0100670) | 1.91258777 |
| 97 | Stillbirth (HP:0003826) | 1.89800978 |
| 98 | Squamous cell carcinoma (HP:0002860) | 1.88344963 |
| 99 | Biliary tract neoplasm (HP:0100574) | 1.87280764 |
| 100 | Duplication of thumb phalanx (HP:0009942) | 1.86458905 |
| 101 | Osteomalacia (HP:0002749) | 1.85394652 |
| 102 | Aplasia/hypoplasia of the humerus (HP:0006507) | 1.83932734 |
| 103 | Facial hemangioma (HP:0000329) | 1.83738778 |
| 104 | Abnormal number of erythroid precursors (HP:0012131) | 1.83355614 |
| 105 | Deep philtrum (HP:0002002) | 1.81481287 |
| 106 | Lymphoma (HP:0002665) | 1.80208296 |
| 107 | Uterine leiomyosarcoma (HP:0002891) | 1.77343440 |
| 108 | Leiomyosarcoma (HP:0100243) | 1.77343440 |
| 109 | Abnormality of the phalanges of the hallux (HP:0010057) | 1.76619218 |
| 110 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.76479564 |
| 111 | Ovarian neoplasm (HP:0100615) | 1.75314587 |
| 112 | Facial cleft (HP:0002006) | 1.75019257 |
| 113 | Short tibia (HP:0005736) | 1.74099717 |
| 114 | Long eyelashes (HP:0000527) | 1.73916349 |
| 115 | Gastrointestinal carcinoma (HP:0002672) | 1.73907631 |
| 116 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.73907631 |
| 117 | Abnormality of the calcaneus (HP:0008364) | 1.73587671 |
| 118 | Rib fusion (HP:0000902) | 1.73501663 |
| 119 | Hypoplastic pelvis (HP:0008839) | 1.73301425 |
| 120 | Bifid tongue (HP:0010297) | 1.73065702 |
| 121 | Cellular immunodeficiency (HP:0005374) | 1.72729107 |
| 122 | Microglossia (HP:0000171) | 1.71162020 |
| 123 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.71109550 |
| 124 | Pallor (HP:0000980) | 1.70959361 |
| 125 | Urethral obstruction (HP:0000796) | 1.70426401 |
| 126 | Abnormality of reticulocytes (HP:0004312) | 1.70245920 |
| 127 | Overlapping toe (HP:0001845) | 1.69814510 |
| 128 | Premature ovarian failure (HP:0008209) | 1.68535488 |
| 129 | Skull defect (HP:0001362) | 1.66406203 |
| 130 | Abnormality of the fingertips (HP:0001211) | 1.65493256 |
| 131 | Abnormal spermatogenesis (HP:0008669) | 1.63729745 |
| 132 | Spinal muscular atrophy (HP:0007269) | 1.62398833 |
| 133 | Thyroid carcinoma (HP:0002890) | 1.62227846 |
| 134 | Cleft eyelid (HP:0000625) | 1.61987337 |
| 135 | Uterine neoplasm (HP:0010784) | 1.60653423 |
| 136 | Sensory axonal neuropathy (HP:0003390) | 1.60541730 |
| 137 | Progressive external ophthalmoplegia (HP:0000590) | 1.58953866 |
| 138 | Enlarged penis (HP:0000040) | 1.58264905 |
| 139 | Abnormal auditory evoked potentials (HP:0006958) | 1.57048539 |
| 140 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.56950880 |
| 141 | Hypoplasia of the fovea (HP:0007750) | 1.56950880 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDC7 | 4.66145130 |
| 2 | BUB1 | 4.43005781 |
| 3 | WEE1 | 3.80310486 |
| 4 | NEK2 | 3.42062414 |
| 5 | TTK | 3.20096329 |
| 6 | CDK12 | 2.93757068 |
| 7 | NEK1 | 2.48383581 |
| 8 | PLK4 | 2.38453172 |
| 9 | SRPK1 | 2.37537387 |
| 10 | PLK1 | 2.30397625 |
| 11 | EIF2AK1 | 2.19012832 |
| 12 | BRSK2 | 2.13061773 |
| 13 | AURKB | 1.99333388 |
| 14 | ZAK | 1.92273854 |
| 15 | ATR | 1.90446251 |
| 16 | STK10 | 1.88849484 |
| 17 | PLK3 | 1.86719939 |
| 18 | CHEK2 | 1.86262317 |
| 19 | TLK1 | 1.82132799 |
| 20 | MAP3K9 | 1.80300299 |
| 21 | PASK | 1.79771836 |
| 22 | TSSK6 | 1.78765889 |
| 23 | STK4 | 1.71822820 |
| 24 | RPS6KB2 | 1.71702198 |
| 25 | CDK7 | 1.70415029 |
| 26 | VRK2 | 1.64232351 |
| 27 | EEF2K | 1.62679316 |
| 28 | MKNK1 | 1.56722946 |
| 29 | MAP3K8 | 1.54245876 |
| 30 | MST4 | 1.52889640 |
| 31 | BRSK1 | 1.49127152 |
| 32 | EPHA2 | 1.48689011 |
| 33 | VRK1 | 1.48553579 |
| 34 | TRIM28 | 1.46578483 |
| 35 | CDK4 | 1.45067461 |
| 36 | ACVR1B | 1.44586096 |
| 37 | CHEK1 | 1.40535950 |
| 38 | TESK2 | 1.38497449 |
| 39 | NUAK1 | 1.37260339 |
| 40 | BRD4 | 1.36431029 |
| 41 | MAP3K10 | 1.33552699 |
| 42 | TNIK | 1.24145395 |
| 43 | TAF1 | 1.20288289 |
| 44 | * AURKA | 1.17380249 |
| 45 | ARAF | 1.13200833 |
| 46 | ATM | 1.12619391 |
| 47 | EIF2AK3 | 1.11078706 |
| 48 | DYRK3 | 1.10378399 |
| 49 | MKNK2 | 1.08222250 |
| 50 | RPS6KA4 | 1.07632958 |
| 51 | MET | 1.05405511 |
| 52 | MELK | 1.03909469 |
| 53 | CDK6 | 1.01770190 |
| 54 | TGFBR1 | 0.98465858 |
| 55 | * CDK2 | 0.94352677 |
| 56 | STK24 | 0.94248851 |
| 57 | PIM1 | 0.93985735 |
| 58 | NME2 | 0.93667158 |
| 59 | FLT3 | 0.93513569 |
| 60 | STK3 | 0.92640721 |
| 61 | SCYL2 | 0.92019066 |
| 62 | CCNB1 | 0.91634158 |
| 63 | PAK4 | 0.89483403 |
| 64 | NEK6 | 0.88642495 |
| 65 | PBK | 0.79043807 |
| 66 | * CDK1 | 0.77061322 |
| 67 | PKN2 | 0.75223196 |
| 68 | EIF2AK2 | 0.73648637 |
| 69 | ALK | 0.70426373 |
| 70 | MAP3K13 | 0.66245224 |
| 71 | RAF1 | 0.66097653 |
| 72 | CLK1 | 0.65619526 |
| 73 | STK38L | 0.65310194 |
| 74 | LATS1 | 0.64475726 |
| 75 | STK16 | 0.57587661 |
| 76 | TESK1 | 0.57094150 |
| 77 | PNCK | 0.56143109 |
| 78 | BRAF | 0.53607578 |
| 79 | WNK3 | 0.53561801 |
| 80 | PAK1 | 0.53486631 |
| 81 | CSNK2A1 | 0.53184130 |
| 82 | MARK3 | 0.52878540 |
| 83 | MTOR | 0.52705800 |
| 84 | RPS6KA5 | 0.52558280 |
| 85 | CSNK2A2 | 0.52032318 |
| 86 | ERBB4 | 0.51502754 |
| 87 | DMPK | 0.49713250 |
| 88 | MAP4K1 | 0.49574064 |
| 89 | CSNK1G1 | 0.48545559 |
| 90 | CDK8 | 0.46772683 |
| 91 | PLK2 | 0.45119165 |
| 92 | PRKCI | 0.44792017 |
| 93 | LRRK2 | 0.44651389 |
| 94 | PRKDC | 0.44027489 |
| 95 | MAP2K3 | 0.43375325 |
| 96 | BMPR1B | 0.42127073 |
| 97 | CDK9 | 0.41309267 |
| 98 | KSR1 | 0.40952230 |
| 99 | AKT2 | 0.39336392 |
| 100 | CDK18 | 0.38093749 |
| 101 | CDK15 | 0.37256965 |
| 102 | MAPK14 | 0.36650316 |
| 103 | MOS | 0.36515413 |
| 104 | CDK11A | 0.35011042 |
| 105 | TAOK2 | 0.33061254 |
| 106 | BTK | 0.32363934 |
| 107 | AKT1 | 0.32006095 |
| 108 | STK39 | 0.31529707 |
| 109 | CSNK1D | 0.31457973 |
| 110 | FGFR1 | 0.30680135 |
| 111 | CDK14 | 0.30392592 |
| 112 | JAK3 | 0.30006083 |
| 113 | CDK3 | 0.29613083 |
| 114 | CHUK | 0.29216516 |
| 115 | NME1 | 0.28983791 |
| 116 | TIE1 | 0.27423492 |
| 117 | SMG1 | 0.26366737 |
| 118 | BCR | 0.26044577 |
| 119 | YES1 | 0.25883258 |
| 120 | TTN | 0.25820419 |
| 121 | CSNK1E | 0.25707714 |
| 122 | TRPM7 | 0.23924410 |
| 123 | * MAPK1 | 0.23791968 |
| 124 | NEK9 | 0.23703361 |
| 125 | GSK3B | 0.22687282 |
| 126 | LATS2 | 0.21638330 |
| 127 | ERBB3 | 0.21328572 |
| 128 | MAPKAPK2 | 0.19673347 |
| 129 | TEC | 0.18983994 |
| 130 | AKT3 | 0.18917514 |
| 131 | MAPK11 | 0.18695041 |
| 132 | MAPKAPK3 | 0.18234734 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.83935329 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 4.37528792 |
| 3 | Cell cycle_Homo sapiens_hsa04110 | 3.27777096 |
| 4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.24751752 |
| 5 | Homologous recombination_Homo sapiens_hsa03440 | 3.23302746 |
| 6 | Base excision repair_Homo sapiens_hsa03410 | 3.14533724 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 3.09459093 |
| 8 | RNA transport_Homo sapiens_hsa03013 | 3.09434092 |
| 9 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.79155888 |
| 10 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.76880276 |
| 11 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.71123487 |
| 12 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.47048961 |
| 13 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.43448793 |
| 14 | RNA polymerase_Homo sapiens_hsa03020 | 2.38392089 |
| 15 | Ribosome_Homo sapiens_hsa03010 | 2.28883580 |
| 16 | Proteasome_Homo sapiens_hsa03050 | 2.00450092 |
| 17 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.98114910 |
| 18 | RNA degradation_Homo sapiens_hsa03018 | 1.97575059 |
| 19 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.96783361 |
| 20 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.95642976 |
| 21 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.94108305 |
| 22 | Basal transcription factors_Homo sapiens_hsa03022 | 1.86178027 |
| 23 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.53549978 |
| 24 | Protein export_Homo sapiens_hsa03060 | 1.33943264 |
| 25 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.32974208 |
| 26 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.22396207 |
| 27 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.21435114 |
| 28 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.20384008 |
| 29 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.18995415 |
| 30 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.16324177 |
| 31 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.12735121 |
| 32 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.08786736 |
| 33 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.06317538 |
| 34 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.04863095 |
| 35 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.01704080 |
| 36 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.00367014 |
| 37 | Purine metabolism_Homo sapiens_hsa00230 | 0.99749601 |
| 38 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.98844525 |
| 39 | HTLV-I infection_Homo sapiens_hsa05166 | 0.98101865 |
| 40 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.97255612 |
| 41 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.89302270 |
| 42 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.88342727 |
| 43 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.86001862 |
| 44 | Alcoholism_Homo sapiens_hsa05034 | 0.83759043 |
| 45 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.83146936 |
| 46 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.79328268 |
| 47 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.79251347 |
| 48 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.76162327 |
| 49 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.71673639 |
| 50 | Carbon metabolism_Homo sapiens_hsa01200 | 0.71140680 |
| 51 | Huntingtons disease_Homo sapiens_hsa05016 | 0.69503553 |
| 52 | Legionellosis_Homo sapiens_hsa05134 | 0.68594900 |
| 53 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.66476358 |
| 54 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.66404284 |
| 55 | Apoptosis_Homo sapiens_hsa04210 | 0.66122846 |
| 56 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.66044654 |
| 57 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.64885978 |
| 58 | Thyroid cancer_Homo sapiens_hsa05216 | 0.64512923 |
| 59 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.60778299 |
| 60 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.60735983 |
| 61 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.60127731 |
| 62 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.60096586 |
| 63 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.59306150 |
| 64 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.58598878 |
| 65 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.58069666 |
| 66 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.57872123 |
| 67 | Measles_Homo sapiens_hsa05162 | 0.57518377 |
| 68 | Adherens junction_Homo sapiens_hsa04520 | 0.57085822 |
| 69 | Colorectal cancer_Homo sapiens_hsa05210 | 0.56344870 |
| 70 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.54671711 |
| 71 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.54624441 |
| 72 | Hepatitis B_Homo sapiens_hsa05161 | 0.53672979 |
| 73 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.52737457 |
| 74 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.50753694 |
| 75 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.47207768 |
| 76 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.46284914 |
| 77 | Parkinsons disease_Homo sapiens_hsa05012 | 0.45780609 |
| 78 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.44029201 |
| 79 | Influenza A_Homo sapiens_hsa05164 | 0.43876881 |
| 80 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.43253308 |
| 81 | Shigellosis_Homo sapiens_hsa05131 | 0.42765491 |
| 82 | Bladder cancer_Homo sapiens_hsa05219 | 0.42463014 |
| 83 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.42223645 |
| 84 | Viral myocarditis_Homo sapiens_hsa05416 | 0.41110145 |
| 85 | Pathways in cancer_Homo sapiens_hsa05200 | 0.40829866 |
| 86 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.40574104 |
| 87 | Lysine degradation_Homo sapiens_hsa00310 | 0.40049184 |
| 88 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.39392403 |
| 89 | Gap junction_Homo sapiens_hsa04540 | 0.39036129 |
| 90 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.37944084 |
| 91 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.37645342 |
| 92 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.37265884 |
| 93 | Prostate cancer_Homo sapiens_hsa05215 | 0.36861316 |
| 94 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.34786460 |
| 95 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.34080898 |
| 96 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.32750159 |
| 97 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.32046094 |
| 98 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.31767183 |
| 99 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.30346336 |
| 100 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.29517272 |
| 101 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.29337773 |
| 102 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.28209549 |
| 103 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.28202428 |
| 104 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.28197300 |
| 105 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.27967336 |
| 106 | Metabolic pathways_Homo sapiens_hsa01100 | 0.26742204 |
| 107 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.26738546 |
| 108 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.25179457 |
| 109 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.25127344 |
| 110 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.25096511 |
| 111 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.24480201 |
| 112 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.24426994 |
| 113 | Asthma_Homo sapiens_hsa05310 | 0.24243684 |
| 114 | Leishmaniasis_Homo sapiens_hsa05140 | 0.23844374 |
| 115 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.22734103 |
| 116 | Melanoma_Homo sapiens_hsa05218 | 0.22429375 |
| 117 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.21363353 |
| 118 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.21286769 |
| 119 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.20556170 |
| 120 | Olfactory transduction_Homo sapiens_hsa04740 | 0.19755696 |
| 121 | Endometrial cancer_Homo sapiens_hsa05213 | 0.18590348 |
| 122 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.18283849 |
| 123 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.18267160 |
| 124 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.18118046 |
| 125 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.18007062 |
| 126 | Tight junction_Homo sapiens_hsa04530 | 0.17529899 |
| 127 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.17427806 |
| 128 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.17291336 |
| 129 | Allograft rejection_Homo sapiens_hsa05330 | 0.17259936 |
| 130 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.15320613 |
| 131 | Circadian rhythm_Homo sapiens_hsa04710 | 0.12011548 |
| 132 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.06769491 |
| 133 | Sulfur relay system_Homo sapiens_hsa04122 | 0.04462194 |
| 134 | Melanogenesis_Homo sapiens_hsa04916 | 0.03983428 |
| 135 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.03242221 |

