DLK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)7.51322454
2dopamine biosynthetic process (GO:0042416)5.28797140
3neuronal stem cell maintenance (GO:0097150)5.26148649
4ribosomal small subunit assembly (GO:0000028)5.13248433
5cell proliferation in forebrain (GO:0021846)5.04301052
6somite development (GO:0061053)4.91605757
7body morphogenesis (GO:0010171)4.57997744
8viral transcription (GO:0019083)4.56142238
9intraciliary transport (GO:0042073)4.49824753
10behavioral response to nicotine (GO:0035095)4.42743437
11neuron fate determination (GO:0048664)4.42557198
12cerebellar Purkinje cell layer development (GO:0021680)4.41158907
13bone trabecula formation (GO:0060346)4.38020835
14translational termination (GO:0006415)4.32824553
15regulation of non-canonical Wnt signaling pathway (GO:2000050)4.32152759
16nonmotile primary cilium assembly (GO:0035058)4.29796965
17cell proliferation involved in metanephros development (GO:0072203)4.29335885
18tongue development (GO:0043586)4.16271826
19substrate-independent telencephalic tangential migration (GO:0021826)4.13859526
20substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.13859526
21positive regulation of growth hormone secretion (GO:0060124)4.12882328
22growth hormone secretion (GO:0030252)4.10551111
23calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)4.02539268
24gonadal mesoderm development (GO:0007506)3.96497331
25planar cell polarity pathway involved in neural tube closure (GO:0090179)3.96421747
26collagen fibril organization (GO:0030199)3.95533078
27regulation of growth hormone secretion (GO:0060123)3.92335992
28dopamine transport (GO:0015872)3.87175695
29polarized epithelial cell differentiation (GO:0030859)3.86821247
30short-term memory (GO:0007614)3.83846895
31SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.83373362
32regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.81830133
33axon extension involved in axon guidance (GO:0048846)3.81631138
34neuron projection extension involved in neuron projection guidance (GO:1902284)3.81631138
35outer ear morphogenesis (GO:0042473)3.79600660
36anatomical structure regression (GO:0060033)3.78779849
37mating behavior (GO:0007617)3.78329498
38cotranslational protein targeting to membrane (GO:0006613)3.78300704
39appendage development (GO:0048736)3.76980538
40limb development (GO:0060173)3.76980538
41head development (GO:0060322)3.75779310
42radial glial cell differentiation (GO:0060019)3.74092377
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.73728413
44protein targeting to ER (GO:0045047)3.69069197
45positive regulation of gastrulation (GO:2000543)3.68395576
46positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.68130053
47regulation of cell fate specification (GO:0042659)3.67009102
48olfactory bulb development (GO:0021772)3.64921941
49convergent extension (GO:0060026)3.64252225
50collagen catabolic process (GO:0030574)3.64004513
51collagen metabolic process (GO:0032963)3.62354839
52extracellular fibril organization (GO:0043206)3.60610997
53response to parathyroid hormone (GO:0071107)3.59995442
54pyrimidine nucleobase catabolic process (GO:0006208)3.59041771
55exocrine pancreas development (GO:0031017)3.54879826
56toxin metabolic process (GO:0009404)3.53791277
57response to insecticide (GO:0017085)3.53085795
58establishment of protein localization to endoplasmic reticulum (GO:0072599)3.52883003
59epithelial cilium movement (GO:0003351)3.50289738
60protein localization to endoplasmic reticulum (GO:0070972)3.49811719
61catecholamine transport (GO:0051937)3.48552869
62translational elongation (GO:0006414)3.46263017
63alkaloid metabolic process (GO:0009820)3.44488732
64dorsal/ventral pattern formation (GO:0009953)3.43278222
65nephron epithelium morphogenesis (GO:0072088)3.42403046
66nephron tubule morphogenesis (GO:0072078)3.42403046
67multicellular organismal macromolecule metabolic process (GO:0044259)3.39882175
68nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.39812438
69positive regulation of mitochondrial fission (GO:0090141)3.36884626
70multicellular organismal catabolic process (GO:0044243)3.34316076
71sequestering of actin monomers (GO:0042989)3.33664981
72cardiac left ventricle morphogenesis (GO:0003214)3.31955888
73viral life cycle (GO:0019058)3.30844026
74cellular protein complex disassembly (GO:0043624)3.29733968
75regulation of neuroblast proliferation (GO:1902692)3.29607092
76neurotransmitter catabolic process (GO:0042135)3.26908990
77G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.25880056
78phenol-containing compound catabolic process (GO:0019336)3.23533156
79catechol-containing compound biosynthetic process (GO:0009713)3.22779306
80catecholamine biosynthetic process (GO:0042423)3.22779306
81multicellular organismal metabolic process (GO:0044236)3.21090591
82mesenchyme morphogenesis (GO:0072132)3.20692638
83chromatin remodeling at centromere (GO:0031055)3.20304264
84ribosomal small subunit biogenesis (GO:0042274)3.19949476
85regulation of mesoderm development (GO:2000380)3.19827526
86insulin-like growth factor receptor signaling pathway (GO:0048009)3.15466148
87respiratory system process (GO:0003016)3.14032586
88response to nitrosative stress (GO:0051409)3.12967803
89protein complex disassembly (GO:0043241)3.12566100
90paraxial mesoderm development (GO:0048339)3.11975366
91extracellular matrix disassembly (GO:0022617)3.10173409
92positive regulation of glycogen biosynthetic process (GO:0045725)3.09773516
93regulation of axon extension involved in axon guidance (GO:0048841)3.09192235
94retinal ganglion cell axon guidance (GO:0031290)3.07550964
95left/right axis specification (GO:0070986)3.04868018
96skin morphogenesis (GO:0043589)3.01771174
97regulation of glycogen (starch) synthase activity (GO:2000465)3.00570496
98positive regulation of glomerulus development (GO:0090193)3.00384304
99maturation of SSU-rRNA (GO:0030490)2.99662371
100cell proliferation involved in kidney development (GO:0072111)2.98753269
101negative regulation of fatty acid transport (GO:2000192)2.98330196
102RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.97332270
103tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.97332270
104negative regulation of chondrocyte differentiation (GO:0032331)2.95305305
105cilium movement (GO:0003341)2.94847697
106macromolecular complex disassembly (GO:0032984)2.94443851
107renal tubule morphogenesis (GO:0061333)2.94285984
108synaptic vesicle maturation (GO:0016188)2.94191620
109segment specification (GO:0007379)2.94183537
110metanephric mesenchyme development (GO:0072075)2.93498950
111L-serine metabolic process (GO:0006563)2.92623261
112positive regulation of Notch signaling pathway (GO:0045747)2.90763074
113middle ear morphogenesis (GO:0042474)2.88120804
114regulation of cilium movement (GO:0003352)2.87931573
115glial cell migration (GO:0008347)2.87552066
116pituitary gland development (GO:0021983)2.87318168
117smoothened signaling pathway (GO:0007224)2.86931719
118neuron cell-cell adhesion (GO:0007158)2.86844068
119serotonin metabolic process (GO:0042428)2.86081045
120sequestering of extracellular ligand from receptor (GO:0035581)2.85847604
121positive regulation of glycogen metabolic process (GO:0070875)2.85332166
122Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.85050396
123nucleobase catabolic process (GO:0046113)2.85046885
124dentate gyrus development (GO:0021542)2.84472657
125neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.82029118
126DNA integration (GO:0015074)2.81586608
127regulation of dopamine metabolic process (GO:0042053)2.81332874
128regulation of catecholamine metabolic process (GO:0042069)2.81332874
129regulation of establishment of planar polarity (GO:0090175)2.81010777
130heart morphogenesis (GO:0003007)2.80713321
131regulation of axon guidance (GO:1902667)2.80564663
132lens morphogenesis in camera-type eye (GO:0002089)2.79359369
133axonal fasciculation (GO:0007413)2.78677434
134negative regulation of embryonic development (GO:0045992)2.78356043
135fibril organization (GO:0097435)2.78133755
136lung-associated mesenchyme development (GO:0060484)2.78118067
137positive regulation of neuroblast proliferation (GO:0002052)2.77748308
138auditory receptor cell differentiation (GO:0042491)2.76794110
139neuromuscular process controlling posture (GO:0050884)2.76403319
140layer formation in cerebral cortex (GO:0021819)2.75299406
141forebrain morphogenesis (GO:0048853)2.74832728
142cilium morphogenesis (GO:0060271)2.73853214
143response to corticosterone (GO:0051412)2.73845417
144kidney mesenchyme development (GO:0072074)2.73228504
145protein polyglutamylation (GO:0018095)2.72741906
146negative regulation of axon extension involved in axon guidance (GO:0048843)2.72659940
147chondrocyte proliferation (GO:0035988)2.71400563
148ephrin receptor signaling pathway (GO:0048013)2.71249196
149synaptic vesicle exocytosis (GO:0016079)2.70780216
150regulation of short-term neuronal synaptic plasticity (GO:0048172)2.70205636
151exploration behavior (GO:0035640)2.69930841
152proximal/distal pattern formation (GO:0009954)2.69436305
153regulation of feeding behavior (GO:0060259)2.68287862
154regulation of cell fate commitment (GO:0010453)2.68031186
155mesenchymal cell proliferation (GO:0010463)2.67865902
156negative regulation of catenin import into nucleus (GO:0035414)2.67159499
157negative regulation of Ras GTPase activity (GO:0034261)2.66902175
158endodermal cell differentiation (GO:0035987)2.65167448
159genetic imprinting (GO:0071514)2.64789138
160pyrimidine dimer repair (GO:0006290)2.64281420
161basement membrane organization (GO:0071711)2.64182445
162chemosensory behavior (GO:0007635)2.63433020
163heterochromatin organization (GO:0070828)2.62494548
164endocardial cushion morphogenesis (GO:0003203)2.61827043
165hippo signaling (GO:0035329)2.61569111
166activation of protein kinase A activity (GO:0034199)2.61286366
167negative regulation of oligodendrocyte differentiation (GO:0048715)2.60558710
168translational initiation (GO:0006413)2.60048557
169dopamine metabolic process (GO:0042417)2.59979924
170positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.59573015
171mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.59573015
172cellular response to amino acid stimulus (GO:0071230)2.58685932
173telencephalon development (GO:0021537)2.58574686
174regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.58231748
175developmental induction (GO:0031128)2.57274987
176negative regulation of cartilage development (GO:0061037)2.56686201
177postsynaptic membrane organization (GO:0001941)2.56199292
178spinal cord association neuron differentiation (GO:0021527)2.56117228
179locomotory exploration behavior (GO:0035641)2.55972990
180establishment of apical/basal cell polarity (GO:0035089)2.55547915
181thalamus development (GO:0021794)2.54911183
182cochlea morphogenesis (GO:0090103)2.54808776
183regulation of gastrulation (GO:0010470)2.54728193
184kinetochore assembly (GO:0051382)2.54643969
185sensory organ development (GO:0007423)2.53899865
186neuron recognition (GO:0008038)2.52586712
187craniofacial suture morphogenesis (GO:0097094)2.51883131
188anatomical structure maturation (GO:0071695)2.50980631
189cell migration involved in heart development (GO:0060973)2.49734953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.09125138
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.81821202
3EZH2_22144423_ChIP-Seq_EOC_Human3.50249037
4IRF1_19129219_ChIP-ChIP_H3396_Human3.24405683
5* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.86221471
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.86221471
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74708481
8* EED_16625203_ChIP-ChIP_MESCs_Mouse2.72188634
9* EZH2_27304074_Chip-Seq_ESCs_Mouse2.71681704
10* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.71595040
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.70023791
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64380462
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.60122346
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.55925714
15* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.52856605
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.52605795
17* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45323131
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44667476
19* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42644679
20* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41343541
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.40509942
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.35177113
23SOX2_18555785_ChIP-Seq_MESCs_Mouse2.33609116
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.31132996
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.29493094
26* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18566810
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17562057
28DROSHA_22980978_ChIP-Seq_HELA_Human2.16805737
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16117465
30* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14461917
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13936119
32* RNF2_27304074_Chip-Seq_ESCs_Mouse2.12687040
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.11046723
34* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.07959530
35ZNF274_21170338_ChIP-Seq_K562_Hela2.07215224
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.06315112
37ERG_21242973_ChIP-ChIP_JURKAT_Human2.05605269
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.04482647
39* EZH2_27294783_Chip-Seq_ESCs_Mouse2.03820350
40SOX2_16153702_ChIP-ChIP_HESCs_Human2.02706293
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.00905375
42* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00902014
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.93745894
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.88401667
45MYC_18940864_ChIP-ChIP_HL60_Human1.84329812
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.82902826
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.79298822
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.77327574
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.75426301
50KDM2B_26808549_Chip-Seq_K562_Human1.74816314
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.73122480
52RNF2_27304074_Chip-Seq_NSC_Mouse1.72227851
53* TP53_20018659_ChIP-ChIP_R1E_Mouse1.71272270
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70609551
55DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.70181771
56* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.66030974
57* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63017791
58CLOCK_20551151_ChIP-Seq_293T_Human1.62957231
59SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.62827494
60LXR_22292898_ChIP-Seq_THP-1_Human1.60040100
61* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.59991826
62* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.56540710
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.55503365
64* RING1B_27294783_Chip-Seq_ESCs_Mouse1.55273611
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.54129019
66FUS_26573619_Chip-Seq_HEK293_Human1.53316651
67* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.50076574
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48613441
69KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.48177692
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.44710131
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44485745
72TAF15_26573619_Chip-Seq_HEK293_Human1.43367116
73CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42870680
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.42793088
75XRN2_22483619_ChIP-Seq_HELA_Human1.40820149
76* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40522487
77* RING1B_27294783_Chip-Seq_NPCs_Mouse1.38205051
78* ISL1_27105846_Chip-Seq_CPCs_Mouse1.37703007
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37609011
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35546866
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.34764820
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.33302021
83* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32101746
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29571633
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29325735
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.28543718
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28246106
88* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28074781
89EST1_17652178_ChIP-ChIP_JURKAT_Human1.27202195
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26363739
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25977652
92CREB1_26743006_Chip-Seq_LNCaP_Human1.24520132
93TTF2_22483619_ChIP-Seq_HELA_Human1.24387153
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23878820
95E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23472581
96TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.22516443
97GABP_19822575_ChIP-Seq_HepG2_Human1.22208911
98KDM2B_26808549_Chip-Seq_JURKAT_Human1.21715430
99ETS1_20019798_ChIP-Seq_JURKAT_Human1.20657045
100EGR1_19374776_ChIP-ChIP_THP-1_Human1.19813268
101ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19579908
102ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18850314
103WT1_19549856_ChIP-ChIP_CCG9911_Human1.18791800
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17987561
105EWS_26573619_Chip-Seq_HEK293_Human1.17866814
106LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17743681
107KDM2B_26808549_Chip-Seq_DND41_Human1.16559633
108NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14031103
109SALL1_21062744_ChIP-ChIP_HESCs_Human1.13836518
110SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13178969
111SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11654335
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11059083
113* CTCF_27219007_Chip-Seq_Bcells_Human1.10727911
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09868979
115TP63_19390658_ChIP-ChIP_HaCaT_Human1.08923048
116GATA1_26923725_Chip-Seq_HPCs_Mouse1.08618719
117P300_19829295_ChIP-Seq_ESCs_Human1.07797474
118JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.07731192
119REST_18959480_ChIP-ChIP_MESCs_Mouse1.06039811
120GBX2_23144817_ChIP-Seq_PC3_Human1.05386345
121CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04475199
122SOX2_18692474_ChIP-Seq_MEFs_Mouse1.04461922
123POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.03734881
124PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02444587
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02112416
126HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02085873
127RARB_27405468_Chip-Seq_BRAIN_Mouse1.01930089
128MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01377480
129* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00923009
130HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00757935
131RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00680914
132ZNF263_19887448_ChIP-Seq_K562_Human0.99907839
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99704588
134P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97432189
135CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97258179
136* AR_19668381_ChIP-Seq_PC3_Human0.97167652
137* REST_21632747_ChIP-Seq_MESCs_Mouse0.97155435
138CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97067379
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96862907
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96862907
141SOX3_22085726_ChIP-Seq_NPCs_Mouse0.96447967
142GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95780829
143TP53_22127205_ChIP-Seq_IMR90_Human0.95742872
144SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95095632
145CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94768630
146TP53_18474530_ChIP-ChIP_U2OS_Human0.94234118
147FOXP3_21729870_ChIP-Seq_TREG_Human0.93742784
148CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93623749
149AR_21572438_ChIP-Seq_LNCaP_Human0.93568044
150EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92725981
151TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92389079
152MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92310020
153YY1_21170310_ChIP-Seq_MESCs_Mouse0.91417821
154IGF1R_20145208_ChIP-Seq_DFB_Human0.91322795
155* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.91270116
156* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91058316
157DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90456662
158KLF4_19829295_ChIP-Seq_ESCs_Human0.90308318
159SOX2_18692474_ChIP-Seq_MESCs_Mouse0.90043502
160* RACK7_27058665_Chip-Seq_MCF-7_Human0.88799826
161SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.88159389
162TET1_21490601_ChIP-Seq_MESCs_Mouse0.86893118
163SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86891214
164ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85834127
165EP300_21415370_ChIP-Seq_HL-1_Mouse0.84935650
166SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83875270
167NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82879193
168SMAD3_21741376_ChIP-Seq_ESCs_Human0.81844543

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003122_maternal_imprinting6.36880821
2MP0006292_abnormal_olfactory_placode6.08514624
3MP0003123_paternal_imprinting5.21465349
4MP0008438_abnormal_cutaneous_collagen4.80020111
5MP0002653_abnormal_ependyma_morphology4.78075395
6MP0003283_abnormal_digestive_organ3.81938867
7MP0003121_genomic_imprinting3.52131860
8MP0005503_abnormal_tendon_morphology3.40473779
9MP0008789_abnormal_olfactory_epithelium3.38208253
10MP0004272_abnormal_basement_membrane3.07442309
11MP0005499_abnormal_olfactory_system3.00847423
12MP0005394_taste/olfaction_phenotype3.00847423
13MP0001293_anophthalmia2.85135323
14MP0005623_abnormal_meninges_morphology2.80856470
15MP0006276_abnormal_autonomic_nervous2.66530293
16MP0005275_abnormal_skin_tensile2.61433868
17MP0005377_hearing/vestibular/ear_phenot2.39585446
18MP0003878_abnormal_ear_physiology2.39585446
19MP0004133_heterotaxia2.37583765
20MP0003705_abnormal_hypodermis_morpholog2.19785231
21MP0010030_abnormal_orbit_morphology2.18455446
22MP0009379_abnormal_foot_pigmentation2.17276615
23MP0003787_abnormal_imprinting2.16948042
24MP0000566_synostosis2.11306028
25MP0000778_abnormal_nervous_system2.10565295
26MP0003385_abnormal_body_wall2.03938510
27MP0003136_yellow_coat_color1.96120992
28MP0006054_spinal_hemorrhage1.93779743
29MP0000751_myopathy1.83249676
30MP0003942_abnormal_urinary_system1.81256717
31MP0005645_abnormal_hypothalamus_physiol1.77670927
32MP0000534_abnormal_ureter_morphology1.64570280
33MP0001286_abnormal_eye_development1.63639924
34MP0001984_abnormal_olfaction1.57800299
35MP0000013_abnormal_adipose_tissue1.55236807
36MP0002234_abnormal_pharynx_morphology1.54914456
37MP0000462_abnormal_digestive_system1.53043874
38MP0009250_abnormal_appendicular_skeleto1.52613209
39MP0000049_abnormal_middle_ear1.50538938
40MP0005076_abnormal_cell_differentiation1.50245567
41MP0003115_abnormal_respiratory_system1.49353519
42MP0006072_abnormal_retinal_apoptosis1.46654532
43MP0003567_abnormal_fetal_cardiomyocyte1.44043069
44MP0003938_abnormal_ear_development1.43882702
45MP0000428_abnormal_craniofacial_morphol1.43714145
46MP0004147_increased_porphyrin_level1.41212764
47MP0005508_abnormal_skeleton_morphology1.41019581
48MP0001958_emphysema1.39674359
49MP0002697_abnormal_eye_size1.38297800
50MP0000639_abnormal_adrenal_gland1.38154937
51MP0003880_abnormal_central_pattern1.38132019
52MP0000537_abnormal_urethra_morphology1.36381309
53MP0001299_abnormal_eye_distance/1.36100518
54MP0000026_abnormal_inner_ear1.32842080
55MP0004859_abnormal_synaptic_plasticity1.28958153
56MP0004142_abnormal_muscle_tone1.27895061
57MP0002108_abnormal_muscle_morphology1.27100451
58MP0002092_abnormal_eye_morphology1.26829970
59MP0002102_abnormal_ear_morphology1.26377770
60MP0001905_abnormal_dopamine_level1.25765488
61MP0003119_abnormal_digestive_system1.22891657
62MP0002909_abnormal_adrenal_gland1.22011390
63MP0001501_abnormal_sleep_pattern1.21469609
64MP0003279_aneurysm1.20815416
65MP0000003_abnormal_adipose_tissue1.20557749
66MP0004134_abnormal_chest_morphology1.19167003
67MP0004233_abnormal_muscle_weight1.18684995
68MP0008877_abnormal_DNA_methylation1.17097729
69MP0002932_abnormal_joint_morphology1.16632208
70MP0009053_abnormal_anal_canal1.16049739
71MP0002009_preneoplasia1.15537565
72MP0001502_abnormal_circadian_rhythm1.15090886
73MP0005391_vision/eye_phenotype1.11129493
74MP0003959_abnormal_lean_body1.09789350
75MP0003635_abnormal_synaptic_transmissio1.09616140
76MP0000372_irregular_coat_pigmentation1.09306708
77MP0009672_abnormal_birth_weight1.05371906
78MP0005253_abnormal_eye_physiology1.04366778
79MP0001963_abnormal_hearing_physiology1.04199493
80MP0000631_abnormal_neuroendocrine_gland1.03836588
81MP0001485_abnormal_pinna_reflex1.03260018
82MP0004145_abnormal_muscle_electrophysio1.02149464
83MP0009703_decreased_birth_body1.01786446
84MP0002896_abnormal_bone_mineralization1.01736864
85MP0002938_white_spotting1.01043087
86MP0001348_abnormal_lacrimal_gland1.00835538
87MP0002752_abnormal_somatic_nervous0.98292561
88MP0003755_abnormal_palate_morphology0.96300075
89MP0002152_abnormal_brain_morphology0.95768652
90MP0001270_distended_abdomen0.95221363
91MP0002116_abnormal_craniofacial_bone0.94576847
92MP0000569_abnormal_digit_pigmentation0.94540580
93MP0002282_abnormal_trachea_morphology0.94338304
94MP0003693_abnormal_embryo_hatching0.92962075
95MP0002060_abnormal_skin_morphology0.91529029
96MP0000647_abnormal_sebaceous_gland0.90832214
97MP0004858_abnormal_nervous_system0.90406383
98MP0005195_abnormal_posterior_eye0.89178745
99MP0009046_muscle_twitch0.89081300
100MP0005257_abnormal_intraocular_pressure0.88297561
101MP0005220_abnormal_exocrine_pancreas0.88162163
102MP0005379_endocrine/exocrine_gland_phen0.87251679
103MP0002160_abnormal_reproductive_system0.87057284
104MP0001324_abnormal_eye_pigmentation0.86393797
105MP0000733_abnormal_muscle_development0.85842026
106MP0002638_abnormal_pupillary_reflex0.85397755
107MP0002249_abnormal_larynx_morphology0.84052907
108MP0002233_abnormal_nose_morphology0.83898474
109MP0001243_abnormal_dermal_layer0.82735198
110MP0002572_abnormal_emotion/affect_behav0.82001877
111MP0002184_abnormal_innervation0.81849728
112* MP0004197_abnormal_fetal_growth/weight/0.81277792
113MP0008932_abnormal_embryonic_tissue0.80927369
114MP0003935_abnormal_craniofacial_develop0.79435288
115MP0008961_abnormal_basal_metabolism0.79072755
116MP0002177_abnormal_outer_ear0.78286237
117MP0002089_abnormal_postnatal_growth/wei0.77999775
118MP0002557_abnormal_social/conspecific_i0.77090698
119MP0005083_abnormal_biliary_tract0.75761219
120MP0002115_abnormal_skeleton_extremities0.72929422
121MP0002127_abnormal_cardiovascular_syste0.72465115
122MP0001944_abnormal_pancreas_morphology0.72270240
123MP0000955_abnormal_spinal_cord0.71683052
124MP0005248_abnormal_Harderian_gland0.71339759
125* MP0002114_abnormal_axial_skeleton0.70628367
126MP0003941_abnormal_skin_development0.70532350
127MP0002736_abnormal_nociception_after0.70506420
128MP0002733_abnormal_thermal_nociception0.69660705
129* MP0001340_abnormal_eyelid_morphology0.69618183
130MP0003137_abnormal_impulse_conducting0.69600170
131MP0001664_abnormal_digestion0.69514041
132MP0002109_abnormal_limb_morphology0.69124888
133MP0002163_abnormal_gland_morphology0.68798016
134MP0000163_abnormal_cartilage_morphology0.68550324
135MP0001529_abnormal_vocalization0.68023908
136MP0009780_abnormal_chondrocyte_physiolo0.67639755
137MP0001177_atelectasis0.67334302
138MP0003937_abnormal_limbs/digits/tail_de0.66639858
139* MP0002081_perinatal_lethality0.66350707
140MP0002064_seizures0.66110261
141MP0005167_abnormal_blood-brain_barrier0.63805696
142MP0002751_abnormal_autonomic_nervous0.63678774
143MP0005551_abnormal_eye_electrophysiolog0.63169471
144MP0005187_abnormal_penis_morphology0.63107927
145MP0002111_abnormal_tail_morphology0.62995616
146MP0005423_abnormal_somatic_nervous0.62405946
147MP0009384_cardiac_valve_regurgitation0.62131671
148MP0009745_abnormal_behavioral_response0.62075097
149MP0000762_abnormal_tongue_morphology0.61248113
150MP0003861_abnormal_nervous_system0.60809449
151MP0002882_abnormal_neuron_morphology0.60809313
152MP0000678_abnormal_parathyroid_gland0.59964409
153MP0002210_abnormal_sex_determination0.59433791
154MP0005193_abnormal_anterior_eye0.59179445
155MP0002085_abnormal_embryonic_tissue0.56740389
156MP0003315_abnormal_perineum_morphology0.55844157
157MP0000432_abnormal_head_morphology0.55721407
158MP0000383_abnormal_hair_follicle0.55307709
159MP0001486_abnormal_startle_reflex0.54421420
160MP0004885_abnormal_endolymph0.53799779
161MP0000579_abnormal_nail_morphology0.53663858

Predicted human phenotypes

RankGene SetZ-score
1Ankle contracture (HP:0006466)5.85810051
2Protrusio acetabuli (HP:0003179)5.53222593
3Premature rupture of membranes (HP:0001788)5.41909443
4Follicular hyperkeratosis (HP:0007502)5.24761206
5Type 1 muscle fiber predominance (HP:0003803)4.91788813
6Slender build (HP:0001533)4.69510421
7Hypoventilation (HP:0002791)4.68939460
8Fragile skin (HP:0001030)4.25841858
9Bladder diverticulum (HP:0000015)4.16087279
10Atrophic scars (HP:0001075)4.10396703
11Reticulocytopenia (HP:0001896)4.05490494
12Cerebral aneurysm (HP:0004944)4.01991137
13Limb dystonia (HP:0002451)3.89127869
14True hermaphroditism (HP:0010459)3.88719484
15Shallow orbits (HP:0000586)3.80686579
16Colon cancer (HP:0003003)3.72674204
17Rib fusion (HP:0000902)3.71751261
18Mildly elevated creatine phosphokinase (HP:0008180)3.67593377
19Renal duplication (HP:0000075)3.63200698
20Septo-optic dysplasia (HP:0100842)3.61422680
21Anophthalmia (HP:0000528)3.60069971
22Increased variability in muscle fiber diameter (HP:0003557)3.55278337
23Soft skin (HP:0000977)3.54513997
24Pancreatic fibrosis (HP:0100732)3.52391547
25Medial flaring of the eyebrow (HP:0010747)3.45920636
26Spinal rigidity (HP:0003306)3.42747242
27Congenital primary aphakia (HP:0007707)3.40753886
28Gait imbalance (HP:0002141)3.38604743
29Broad metatarsal (HP:0001783)3.32289725
30Bowel diverticulosis (HP:0005222)3.29238026
31Abnormality of dentin (HP:0010299)3.29077514
32Enlarged penis (HP:0000040)3.27353487
33Hypercortisolism (HP:0001578)3.23849683
34Supernumerary spleens (HP:0009799)3.23375964
35Nephrogenic diabetes insipidus (HP:0009806)3.22684187
36Neonatal short-limb short stature (HP:0008921)3.18237041
37Hyperglycinemia (HP:0002154)3.17906395
38High anterior hairline (HP:0009890)3.09017721
39Short 4th metacarpal (HP:0010044)3.07678682
40Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.07678682
41Aplasia/Hypoplasia of the breasts (HP:0010311)3.03055380
42Hypoplastic pelvis (HP:0008839)2.98720484
43Increased connective tissue (HP:0009025)2.94368641
44Adrenal hypoplasia (HP:0000835)2.94255458
45Peritonitis (HP:0002586)2.93920389
46Abnormality of skeletal muscle fiber size (HP:0012084)2.93592442
47Renovascular hypertension (HP:0100817)2.93187947
48Pancreatic cysts (HP:0001737)2.92167002
49Aortic dissection (HP:0002647)2.90893060
50Narrow nasal bridge (HP:0000446)2.87471815
51Sclerocornea (HP:0000647)2.86715785
52Breast aplasia (HP:0100783)2.81694381
53Morphological abnormality of the middle ear (HP:0008609)2.81284839
54Abnormality of cells of the erythroid lineage (HP:0012130)2.81038937
55Postaxial foot polydactyly (HP:0001830)2.80840747
56Neoplasm of the heart (HP:0100544)2.74220808
57Striae distensae (HP:0001065)2.74052914
58Mitral valve prolapse (HP:0001634)2.73132647
59Poor coordination (HP:0002370)2.72448150
60Insomnia (HP:0100785)2.65165016
61Hyperacusis (HP:0010780)2.65107008
62Oligodactyly (HP:0012165)2.61145566
63Coronal craniosynostosis (HP:0004440)2.60246005
64Asymmetry of the thorax (HP:0001555)2.59040517
65Deviation of the hallux (HP:0010051)2.58636756
66Turricephaly (HP:0000262)2.54015417
67Oligodactyly (hands) (HP:0001180)2.53132872
68Abnormal number of erythroid precursors (HP:0012131)2.51099843
69Buphthalmos (HP:0000557)2.50781935
70Hallux valgus (HP:0001822)2.50187254
71Genu recurvatum (HP:0002816)2.49264745
72Erectile abnormalities (HP:0100639)2.48960912
73Dilatation of the ascending aorta (HP:0005111)2.48646892
74Failure to thrive in infancy (HP:0001531)2.47913850
75Postaxial hand polydactyly (HP:0001162)2.47651079
76Abnormality of the 4th metacarpal (HP:0010012)2.47168776
77Vaginal atresia (HP:0000148)2.46684216
78Abnormality of abdominal situs (HP:0011620)2.45656237
79Abdominal situs inversus (HP:0003363)2.45656237
80Aplasia/Hypoplasia of the tongue (HP:0010295)2.45172710
81Aplasia/Hypoplasia of the spleen (HP:0010451)2.44744190
82Abnormality of the intervertebral disk (HP:0005108)2.43561464
83Vitreoretinal degeneration (HP:0000655)2.43205432
84Fibular hypoplasia (HP:0003038)2.43023210
85Absent epiphyses (HP:0010577)2.40283075
86Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.40283075
87Joint laxity (HP:0001388)2.38800800
88Broad foot (HP:0001769)2.37757519
89Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.36087036
90Abnormality of midbrain morphology (HP:0002418)2.35904101
91Molar tooth sign on MRI (HP:0002419)2.35904101
92Menstrual irregularities (HP:0000858)2.35781357
93Exercise-induced muscle cramps (HP:0003710)2.33902907
94Limb-girdle muscle weakness (HP:0003325)2.33514485
95Disproportionate short-trunk short stature (HP:0003521)2.33487323
96Genital tract atresia (HP:0001827)2.33021469
97Abnormality of the proximal phalanges of the hand (HP:0009834)2.32742819
98Cystic liver disease (HP:0006706)2.32478363
99Optic nerve hypoplasia (HP:0000609)2.32201505
100Protruding ear (HP:0000411)2.29621047
101Anencephaly (HP:0002323)2.29269367
102Nephronophthisis (HP:0000090)2.27522176
103Hepatoblastoma (HP:0002884)2.25532968
104Hyperextensible skin (HP:0000974)2.25288841
105Decreased testicular size (HP:0008734)2.25166121
106Depressed nasal ridge (HP:0000457)2.24559407
107Ectopic kidney (HP:0000086)2.24048122
108Abnormality of the aortic arch (HP:0012303)2.23493296
109Holoprosencephaly (HP:0001360)2.23376029
110Overriding aorta (HP:0002623)2.21342370
111Hydroureter (HP:0000072)2.20925402
112Torticollis (HP:0000473)2.18146160
113Abnormality of reticulocytes (HP:0004312)2.17535813
114Metaphyseal cupping (HP:0003021)2.17387977
115Abnormal biliary tract physiology (HP:0012439)2.16611346
116Bile duct proliferation (HP:0001408)2.16611346
117Agitation (HP:0000713)2.15966878
118Median cleft lip (HP:0000161)2.14924175
119Blue sclerae (HP:0000592)2.12662429
120Slender long bone (HP:0003100)2.12471707
121Rocker bottom foot (HP:0001838)2.12173715
122Testicular neoplasm (HP:0010788)2.11908067
123Biconcave vertebral bodies (HP:0004586)2.11617383
124Urethral obstruction (HP:0000796)2.09480439
125Wormian bones (HP:0002645)2.09407823
126Ankyloglossia (HP:0010296)2.08419807
127Renal dysplasia (HP:0000110)2.08352267
128Elfin facies (HP:0004428)2.08300262
129Hemivertebrae (HP:0002937)2.08277502
130Lymphangioma (HP:0100764)2.07569017
131Occipital encephalocele (HP:0002085)2.07330023
132Flat cornea (HP:0007720)2.06328493
133Asplenia (HP:0001746)2.05819852
134Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.04324973
135Bifid tongue (HP:0010297)2.03499549
136Hyperglycinuria (HP:0003108)2.02473833
137Venous insufficiency (HP:0005293)2.02305654
138Elbow flexion contracture (HP:0002987)2.00736369
139Abnormality of glycine metabolism (HP:0010895)2.00696649
140Abnormality of serine family amino acid metabolism (HP:0010894)2.00696649
141Absent septum pellucidum (HP:0001331)2.00375264
142Specific learning disability (HP:0001328)1.97569411
143Bronchomalacia (HP:0002780)1.97445186
144Preaxial hand polydactyly (HP:0001177)1.96593684
145Osteoarthritis (HP:0002758)1.95931800
146Abnormality of the parietal bone (HP:0002696)1.95844239
147Delayed gross motor development (HP:0002194)1.95739376
148Venous abnormality (HP:0002624)1.95433022
149Thin bony cortex (HP:0002753)1.94492156
150Infantile muscular hypotonia (HP:0008947)1.93736986
151Abnormality of DNA repair (HP:0003254)1.93670116
152Irregular epiphyses (HP:0010582)1.93182870
153Disproportionate tall stature (HP:0001519)1.93074285
154Arthropathy (HP:0003040)1.91230020
155Vertebral clefting (HP:0008428)1.90050270
156Cerebellar dysplasia (HP:0007033)1.89901009
157Macroorchidism (HP:0000053)1.89632409
158Macrocytic anemia (HP:0001972)1.89488659
159Wide anterior fontanel (HP:0000260)1.88989334
160Broad thumb (HP:0011304)1.88432431
161Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88034837
162Congenital hepatic fibrosis (HP:0002612)1.86867377
163Aplasia/Hypoplasia of the fibula (HP:0006492)1.85882191
164Mild short stature (HP:0003502)1.85726889
165Generalized amyotrophy (HP:0003700)1.85379975
166Maternal diabetes (HP:0009800)1.85362684
167Absent eyelashes (HP:0000561)1.85090887
168Thoracolumbar scoliosis (HP:0002944)1.84787285
169Micropenis (HP:0000054)1.84781133
170Broad phalanges of the hand (HP:0009768)1.84140483
171Horseshoe kidney (HP:0000085)1.81791525
172Hypoplasia of the ulna (HP:0003022)1.81755918
173Broad toe (HP:0001837)1.81676635
174Tubulointerstitial nephritis (HP:0001970)1.81365431
175Pheochromocytoma (HP:0002666)1.80665652
176Abnormality of the renal medulla (HP:0100957)1.80601249
177Primary amenorrhea (HP:0000786)1.80397216
178Craniofacial dystonia (HP:0012179)1.79526723
179Dandy-Walker malformation (HP:0001305)1.79410592
180Achilles tendon contracture (HP:0001771)1.78926526
181Flat capital femoral epiphysis (HP:0003370)1.78885967
182Male pseudohermaphroditism (HP:0000037)1.77791104
183Osteopenia (HP:0000938)1.77251410
184Cervical subluxation (HP:0003308)1.77157466
185Nonimmune hydrops fetalis (HP:0001790)1.76893026
186Enlarged kidneys (HP:0000105)1.75935011
187Abnormality of calcium-phosphate metabolism (HP:0100530)1.75224755
188Pointed chin (HP:0000307)1.72212060
189Adducted thumb (HP:0001181)1.71468755
190Broad long bones (HP:0005622)1.70990818
191Wrist flexion contracture (HP:0001239)1.69805682
192Long toe (HP:0010511)1.69666211
193Diastasis recti (HP:0001540)1.69453966
194Congenital glaucoma (HP:0001087)1.68761187
195Sprengel anomaly (HP:0000912)1.68708902
196Sacral dimple (HP:0000960)1.67752920
197Abnormality of the peritoneum (HP:0002585)1.65592440

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.56370680
2CDK194.35991878
3EPHA44.29302356
4PKN23.87507727
5LATS23.77406459
6BCKDK3.76223492
7TRIM283.03522196
8PDGFRA2.81604302
9MAP4K22.72609220
10NTRK32.61137528
11DDR22.60991217
12MAP3K102.58345618
13MAP2K72.51143811
14DYRK1B2.38586921
15MAPKAPK52.32048848
16MKNK12.22293794
17DYRK32.10438021
18MAP3K122.10008147
19NEK12.00994910
20DYRK21.94849183
21SRPK11.92848794
22EPHB21.88411184
23PIK3CA1.82515597
24STK161.80317940
25PTK21.80244118
26RPS6KA41.78645877
27TIE11.77841352
28ERN11.74627560
29PTK61.74517457
30EEF2K1.72418549
31WNK31.71869712
32PASK1.69525701
33RIPK11.68413786
34PAK61.67515465
35ICK1.66551186
36BCR1.63686179
37PNCK1.61647971
38UHMK11.61173817
39BMX1.58926785
40SIK11.58636868
41RET1.57509715
42ZAK1.49477274
43MAP3K91.48341827
44PAK21.47339089
45CSNK1A1L1.46955046
46CSNK1G31.45405539
47MAP3K41.42794358
48WNK11.40456225
49PAK31.37261292
50MINK11.31963673
51TYRO31.31294919
52CSNK1G21.28644883
53LATS11.27758672
54NTRK11.24822123
55LIMK11.22740527
56SCYL21.22358184
57CDC71.19669808
58TNIK1.16953842
59FER1.16564790
60CAMK11.13717166
61NEK21.12322970
62DYRK1A1.11873102
63MAP2K41.10946235
64CSNK1G11.10814115
65CAMK1G1.08500935
66CDK141.05608073
67NUAK11.03943367
68PAK41.03514150
69CAMKK11.03476794
70CDK151.02956203
71FGFR11.02653330
72GRK11.00722131
73CDK180.99228907
74MKNK20.99000696
75PRKD30.98505244
76PLK40.97529782
77KSR20.96155523
78PTK2B0.95428954
79STK110.93314033
80PINK10.92278825
81CDK11A0.91978838
82MAP3K70.91553727
83KSR10.90756743
84NTRK20.89346743
85ADRBK10.88323097
86WNK40.87050540
87MTOR0.86995801
88AURKB0.86901765
89ILK0.85415496
90PLK20.83605419
91CAMK40.83592287
92PLK30.80192345
93DAPK30.79958657
94PLK10.79295998
95ALK0.77158256
96TTK0.76458967
97MAP3K110.75493065
98CAMK2A0.73108446
99BMPR1B0.72740059
100PDGFRB0.69676497
101CHEK20.69460683
102TSSK60.69092658
103GRK70.68663969
104ERBB30.66944008
105PRKCH0.66885204
106FGFR20.63818730
107CDK50.63198794
108ROCK10.63007642
109TAOK10.61602477
110ADRBK20.61590980
111TGFBR10.59123309
112LRRK20.57443625
113ROCK20.56818991
114CDC42BPA0.56700815
115SIK20.55759462
116VRK10.55755244
117PRKD20.55742154
118MAP3K10.53285742
119MOS0.52518340
120ATR0.52469965
121GRK50.52181089
122CSNK1E0.49969600
123CDK30.48564096
124PRKCG0.47527849
125MET0.47490612
126MAPK130.45115430
127CAMK1D0.44086533
128AKT20.43967107
129PRKACA0.43744166
130BRAF0.43737434
131WEE10.43320043
132TTN0.43213001
133LMTK20.43072042
134ERBB20.43014155
135CASK0.42124993
136MAPK90.41573301
137EPHA20.40908164
138HIPK20.40709014
139AURKA0.40475391
140SRC0.39921278
141MARK20.39798556
142MAPK150.39708295
143PRKD10.39359308
144PRKCE0.39175004
145STK380.38275055
146MARK10.37924256
147MAP2K10.37052723
148PRKCI0.36468482
149VRK20.36291514
150BRSK10.35933546
151CSNK2A10.35501688
152PAK10.35116486
153PRKCZ0.34590815
154PKN10.34082238
155CSNK1A10.33182795
156MAP2K20.33154341
157MAPK10.33057238
158CAMKK20.32812636
159CAMK2G0.32745464
160CSNK2A20.32649865
161PRKAA10.31931182
162MAPK80.31361837
163INSRR0.29497233
164ATM0.28862804

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.26268846
2Cocaine addiction_Homo sapiens_hsa050303.55238849
3Protein digestion and absorption_Homo sapiens_hsa049743.22604793
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.74006077
5Steroid biosynthesis_Homo sapiens_hsa001002.71053560
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.67920567
7ECM-receptor interaction_Homo sapiens_hsa045122.62026844
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.56368408
9Amphetamine addiction_Homo sapiens_hsa050312.49483871
10Synaptic vesicle cycle_Homo sapiens_hsa047212.48101705
11Hedgehog signaling pathway_Homo sapiens_hsa043402.35514887
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23414483
13Protein export_Homo sapiens_hsa030602.14943500
14Fatty acid elongation_Homo sapiens_hsa000622.11071252
15Propanoate metabolism_Homo sapiens_hsa006402.10913616
16Glycosaminoglycan degradation_Homo sapiens_hsa005312.10299711
17Basal cell carcinoma_Homo sapiens_hsa052172.06610410
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.06097633
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00999092
20Fanconi anemia pathway_Homo sapiens_hsa034601.98451240
21Dopaminergic synapse_Homo sapiens_hsa047281.97061367
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.94558951
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.92332968
24Nicotine addiction_Homo sapiens_hsa050331.77864809
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.77576927
26Insulin secretion_Homo sapiens_hsa049111.75582483
27Vibrio cholerae infection_Homo sapiens_hsa051101.74921435
28Biosynthesis of amino acids_Homo sapiens_hsa012301.70037885
29Estrogen signaling pathway_Homo sapiens_hsa049151.63205418
30Serotonergic synapse_Homo sapiens_hsa047261.57878034
31GABAergic synapse_Homo sapiens_hsa047271.55860263
32Melanogenesis_Homo sapiens_hsa049161.54249148
33RNA degradation_Homo sapiens_hsa030181.53544904
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.52410589
35Gap junction_Homo sapiens_hsa045401.51941777
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.47518113
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47270876
38Focal adhesion_Homo sapiens_hsa045101.47246492
39Nitrogen metabolism_Homo sapiens_hsa009101.46216253
40Butanoate metabolism_Homo sapiens_hsa006501.45466313
41Oxidative phosphorylation_Homo sapiens_hsa001901.44209347
42Circadian entrainment_Homo sapiens_hsa047131.41693394
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40723802
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.39387211
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.39322630
46Axon guidance_Homo sapiens_hsa043601.38175520
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37647251
48Spliceosome_Homo sapiens_hsa030401.36011537
49Bladder cancer_Homo sapiens_hsa052191.34901342
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33475066
51Pancreatic secretion_Homo sapiens_hsa049721.32631007
52Linoleic acid metabolism_Homo sapiens_hsa005911.32235122
53Sulfur relay system_Homo sapiens_hsa041221.31297148
54Huntingtons disease_Homo sapiens_hsa050161.30523306
55Arginine and proline metabolism_Homo sapiens_hsa003301.30213289
56Base excision repair_Homo sapiens_hsa034101.26758194
57Peroxisome_Homo sapiens_hsa041461.26345108
58Cholinergic synapse_Homo sapiens_hsa047251.24945446
59Amoebiasis_Homo sapiens_hsa051461.23856847
60Hippo signaling pathway_Homo sapiens_hsa043901.22498093
61Renin secretion_Homo sapiens_hsa049241.22260812
62GnRH signaling pathway_Homo sapiens_hsa049121.20160618
63Proteoglycans in cancer_Homo sapiens_hsa052051.20083014
64Mismatch repair_Homo sapiens_hsa034301.19036093
65Glioma_Homo sapiens_hsa052141.18581416
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15046810
67Carbon metabolism_Homo sapiens_hsa012001.14478188
68Long-term depression_Homo sapiens_hsa047301.13793022
69Thyroid hormone synthesis_Homo sapiens_hsa049181.11904495
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.10089781
71Morphine addiction_Homo sapiens_hsa050321.07806597
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07411020
73Fatty acid degradation_Homo sapiens_hsa000711.06001222
74Homologous recombination_Homo sapiens_hsa034401.04339646
75Salivary secretion_Homo sapiens_hsa049701.03898206
76Gastric acid secretion_Homo sapiens_hsa049711.03863374
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03260289
78Thyroid cancer_Homo sapiens_hsa052161.02922109
79Cysteine and methionine metabolism_Homo sapiens_hsa002701.02666058
80Wnt signaling pathway_Homo sapiens_hsa043101.01706292
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01489211
82Notch signaling pathway_Homo sapiens_hsa043301.00961043
83Collecting duct acid secretion_Homo sapiens_hsa049661.00341589
84Fatty acid metabolism_Homo sapiens_hsa012120.99507086
85RNA polymerase_Homo sapiens_hsa030200.99352765
86Type II diabetes mellitus_Homo sapiens_hsa049300.98135150
87Alcoholism_Homo sapiens_hsa050340.97292336
88Long-term potentiation_Homo sapiens_hsa047200.95987983
89Dilated cardiomyopathy_Homo sapiens_hsa054140.95622773
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95614572
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94798869
92Nucleotide excision repair_Homo sapiens_hsa034200.92872061
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91102064
94Basal transcription factors_Homo sapiens_hsa030220.90541067
95Glutathione metabolism_Homo sapiens_hsa004800.89728561
96Ovarian steroidogenesis_Homo sapiens_hsa049130.89635772
97One carbon pool by folate_Homo sapiens_hsa006700.88106919
98Parkinsons disease_Homo sapiens_hsa050120.87801647
99Prion diseases_Homo sapiens_hsa050200.87173246
100Arachidonic acid metabolism_Homo sapiens_hsa005900.86932146
101Melanoma_Homo sapiens_hsa052180.86451829
102Glutamatergic synapse_Homo sapiens_hsa047240.85089034
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.84107354
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82154423
105RNA transport_Homo sapiens_hsa030130.81112356
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79894177
107Metabolic pathways_Homo sapiens_hsa011000.79782219
108Caffeine metabolism_Homo sapiens_hsa002320.79131158
109Chronic myeloid leukemia_Homo sapiens_hsa052200.78933314
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.77635040
111Oocyte meiosis_Homo sapiens_hsa041140.76842844
112Pyrimidine metabolism_Homo sapiens_hsa002400.76322204
113Oxytocin signaling pathway_Homo sapiens_hsa049210.75387891
114cAMP signaling pathway_Homo sapiens_hsa040240.75317524
115Alzheimers disease_Homo sapiens_hsa050100.73029284
116Dorso-ventral axis formation_Homo sapiens_hsa043200.72030358
117Arginine biosynthesis_Homo sapiens_hsa002200.71689002
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.71064966
119Prostate cancer_Homo sapiens_hsa052150.70746663
120Phototransduction_Homo sapiens_hsa047440.70368199
121Taste transduction_Homo sapiens_hsa047420.70265310
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70172165
123Pathways in cancer_Homo sapiens_hsa052000.69875584
124Tyrosine metabolism_Homo sapiens_hsa003500.69164007
125DNA replication_Homo sapiens_hsa030300.68611562
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68353053
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67237228
128ErbB signaling pathway_Homo sapiens_hsa040120.66331894
129Platelet activation_Homo sapiens_hsa046110.66329707
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66144853
131Olfactory transduction_Homo sapiens_hsa047400.65331853
132Ether lipid metabolism_Homo sapiens_hsa005650.65258012
133Renal cell carcinoma_Homo sapiens_hsa052110.64028178
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63875348
135Regulation of autophagy_Homo sapiens_hsa041400.63393515
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62450924
137Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62427526
138Tryptophan metabolism_Homo sapiens_hsa003800.62037163
139Phenylalanine metabolism_Homo sapiens_hsa003600.61726368
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.60282915
141Rap1 signaling pathway_Homo sapiens_hsa040150.59816446
142Glucagon signaling pathway_Homo sapiens_hsa049220.59407407
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58759329
144Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58751421
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.58591453
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57598529
147Insulin signaling pathway_Homo sapiens_hsa049100.57460790
148Purine metabolism_Homo sapiens_hsa002300.56280090
149Galactose metabolism_Homo sapiens_hsa000520.56156212
150Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56139209
151Calcium signaling pathway_Homo sapiens_hsa040200.56052037
152Endometrial cancer_Homo sapiens_hsa052130.55867983
153Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55256815
154Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55194347
155Non-small cell lung cancer_Homo sapiens_hsa052230.55038525
156MAPK signaling pathway_Homo sapiens_hsa040100.53819348
157Fat digestion and absorption_Homo sapiens_hsa049750.53764140
158Lysine degradation_Homo sapiens_hsa003100.53270927
159beta-Alanine metabolism_Homo sapiens_hsa004100.52980704
160Cardiac muscle contraction_Homo sapiens_hsa042600.52815542
161Pyruvate metabolism_Homo sapiens_hsa006200.51776707
162Folate biosynthesis_Homo sapiens_hsa007900.50663979
163MicroRNAs in cancer_Homo sapiens_hsa052060.50605313
164TGF-beta signaling pathway_Homo sapiens_hsa043500.50400147
165Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49013752
166Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48893445
167Tight junction_Homo sapiens_hsa045300.48172974
168N-Glycan biosynthesis_Homo sapiens_hsa005100.47990189
169mRNA surveillance pathway_Homo sapiens_hsa030150.47945738
170p53 signaling pathway_Homo sapiens_hsa041150.47705761
171Vitamin B6 metabolism_Homo sapiens_hsa007500.47096761
172Selenocompound metabolism_Homo sapiens_hsa004500.45642875
173Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45543869
174Retinol metabolism_Homo sapiens_hsa008300.42427818
175Pentose phosphate pathway_Homo sapiens_hsa000300.40302799
176Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37178511
177Chemical carcinogenesis_Homo sapiens_hsa052040.37146515

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