DLK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.49038643
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.36708275
3central nervous system myelination (GO:0022010)5.34659441
4axon ensheathment in central nervous system (GO:0032291)5.34659441
5synaptic vesicle exocytosis (GO:0016079)5.00842354
6behavioral response to nicotine (GO:0035095)4.93384099
7protein insertion into membrane (GO:0051205)4.86587067
8neuron cell-cell adhesion (GO:0007158)4.69533431
9synaptic vesicle maturation (GO:0016188)4.66766114
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.63893350
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.50885311
12vocalization behavior (GO:0071625)4.49400337
13locomotory exploration behavior (GO:0035641)4.47184418
14glutamate secretion (GO:0014047)4.42402779
15dendritic spine morphogenesis (GO:0060997)4.39655913
16protein localization to synapse (GO:0035418)4.28582186
17substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.28068268
18substrate-independent telencephalic tangential migration (GO:0021826)4.28068268
19base-excision repair, AP site formation (GO:0006285)4.26531795
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.23603069
21regulation of synaptic vesicle exocytosis (GO:2000300)4.13508043
22neuron recognition (GO:0008038)4.07338002
23proteasome assembly (GO:0043248)4.04809953
24neuronal action potential propagation (GO:0019227)3.93924061
25positive regulation of mitochondrial fission (GO:0090141)3.91208102
26ionotropic glutamate receptor signaling pathway (GO:0035235)3.90291422
27transmission of nerve impulse (GO:0019226)3.84763672
28regulation of neuronal synaptic plasticity (GO:0048168)3.80461708
29axonal fasciculation (GO:0007413)3.79362571
30regulation of glutamate receptor signaling pathway (GO:1900449)3.78685383
31iron-sulfur cluster assembly (GO:0016226)3.72439028
32metallo-sulfur cluster assembly (GO:0031163)3.72439028
33exploration behavior (GO:0035640)3.70374784
34synaptic vesicle docking involved in exocytosis (GO:0016081)3.68442808
35pyrimidine nucleobase catabolic process (GO:0006208)3.66974985
36regulation of long-term neuronal synaptic plasticity (GO:0048169)3.65003720
37synaptic transmission, glutamatergic (GO:0035249)3.64904073
38long-chain fatty acid biosynthetic process (GO:0042759)3.64818478
39presynaptic membrane assembly (GO:0097105)3.64733771
40glutamate receptor signaling pathway (GO:0007215)3.64531401
41layer formation in cerebral cortex (GO:0021819)3.58417357
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.53627165
43presynaptic membrane organization (GO:0097090)3.53542704
44neuron-neuron synaptic transmission (GO:0007270)3.47948737
45desmosome organization (GO:0002934)3.47880909
46regulation of synaptic vesicle transport (GO:1902803)3.45985213
47myelination (GO:0042552)3.45373290
48negative regulation of neurotransmitter transport (GO:0051589)3.40767736
49axon ensheathment (GO:0008366)3.39931970
50ensheathment of neurons (GO:0007272)3.39931970
51L-amino acid import (GO:0043092)3.39641083
52dendrite morphogenesis (GO:0048813)3.37690698
53neuronal ion channel clustering (GO:0045161)3.35695432
54neurotransmitter secretion (GO:0007269)3.35371542
55fatty acid elongation (GO:0030497)3.33470841
56regulation of dendritic spine morphogenesis (GO:0061001)3.31853293
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26901574
58keratinocyte development (GO:0003334)3.26435983
59glycerophospholipid catabolic process (GO:0046475)3.26408843
60negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.24345316
61positive regulation of membrane potential (GO:0045838)3.21673298
62tRNA modification (GO:0006400)3.19890701
63negative regulation of synaptic transmission, GABAergic (GO:0032229)3.19825802
64gamma-aminobutyric acid transport (GO:0015812)3.17714478
65dendritic spine organization (GO:0097061)3.17579959
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.16446774
67regulation of excitatory postsynaptic membrane potential (GO:0060079)3.16391953
68protein localization to cilium (GO:0061512)3.16174972
69regulation of vesicle fusion (GO:0031338)3.12711780
70regulation of postsynaptic membrane potential (GO:0060078)3.10448485
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.09308953
72mitochondrial respiratory chain complex I assembly (GO:0032981)3.09308953
73NADH dehydrogenase complex assembly (GO:0010257)3.09308953
74ATP synthesis coupled proton transport (GO:0015986)3.08507004
75energy coupled proton transport, down electrochemical gradient (GO:0015985)3.08507004
76respiratory chain complex IV assembly (GO:0008535)3.06466467
77mitochondrial respiratory chain complex assembly (GO:0033108)3.06148213
78regulation of synapse structural plasticity (GO:0051823)3.06111675
79postsynaptic membrane organization (GO:0001941)3.05365507
80protein-cofactor linkage (GO:0018065)3.05061394
81chaperone-mediated protein transport (GO:0072321)3.04012732
82cellular potassium ion homeostasis (GO:0030007)3.03843921
83regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.03291901
84protein complex biogenesis (GO:0070271)3.03012357
85GTP biosynthetic process (GO:0006183)3.01762472
86negative regulation of neurotransmitter secretion (GO:0046929)3.01082909
87pyrimidine dimer repair (GO:0006290)3.00652475
88neurotransmitter transport (GO:0006836)2.99915475
89negative regulation of axonogenesis (GO:0050771)2.99652916
90regulation of synaptic plasticity (GO:0048167)2.99428938
91regulation of neurotransmitter secretion (GO:0046928)2.98497037
92cerebellar granule cell differentiation (GO:0021707)2.98315357
93long-term synaptic potentiation (GO:0060291)2.97283474
94regulation of glutamate secretion (GO:0014048)2.95999791
95positive regulation of neurotransmitter secretion (GO:0001956)2.95767678
96water-soluble vitamin biosynthetic process (GO:0042364)2.95566597
97regulation of dendritic spine development (GO:0060998)2.95543566
98adult walking behavior (GO:0007628)2.95356856
99synapse assembly (GO:0007416)2.95016495
100long-term memory (GO:0007616)2.92684462
101regulation of voltage-gated calcium channel activity (GO:1901385)2.92285104
102pseudouridine synthesis (GO:0001522)2.91768876
103membrane hyperpolarization (GO:0060081)2.91684183
104synaptic vesicle endocytosis (GO:0048488)2.90740269
105mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.90634030
106synapse organization (GO:0050808)2.90517499
107negative regulation of cell aging (GO:0090344)2.90300181
108neurofilament cytoskeleton organization (GO:0060052)2.90211490
109preassembly of GPI anchor in ER membrane (GO:0016254)2.89577298
110short-term memory (GO:0007614)2.89232771
111positive regulation of synapse assembly (GO:0051965)2.89007173
112neurotransmitter-gated ion channel clustering (GO:0072578)2.88335569
113nucleobase catabolic process (GO:0046113)2.88041833
114protein neddylation (GO:0045116)2.87260943
115regulation of glucokinase activity (GO:0033131)2.85257068
116regulation of hexokinase activity (GO:1903299)2.85257068
117negative regulation of axon extension (GO:0030517)2.84510154
118regulation of mitochondrial fission (GO:0090140)2.83579378
119neuromuscular process controlling balance (GO:0050885)2.81048642
120cornea development in camera-type eye (GO:0061303)2.80897188
121acidic amino acid transport (GO:0015800)2.79945725
122learning (GO:0007612)2.79877439
123protein polyglutamylation (GO:0018095)2.79738812
124pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.79653483
125L-glutamate transport (GO:0015813)2.79570840
126establishment of mitochondrion localization (GO:0051654)2.78113614
127GPI anchor metabolic process (GO:0006505)2.78103289
128mating behavior (GO:0007617)2.77730891
129L-serine transport (GO:0015825)2.77521396
130GDP-mannose metabolic process (GO:0019673)2.77203718
131cerebral cortex radially oriented cell migration (GO:0021799)2.76906588
132cell migration in hindbrain (GO:0021535)2.76584946
133auditory behavior (GO:0031223)2.76124709
134proline transport (GO:0015824)2.75981521
135nucleoside transmembrane transport (GO:1901642)2.75526008
136G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.74517769
137regulation of neurotransmitter transport (GO:0051588)2.74503632
138ATP hydrolysis coupled proton transport (GO:0015991)2.74335243
139energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.74335243
140UTP biosynthetic process (GO:0006228)2.73642222
141electron transport chain (GO:0022900)2.72491610
142regulation of protein kinase A signaling (GO:0010738)2.72400699
143positive regulation of dendritic spine development (GO:0060999)2.72303599
144respiratory electron transport chain (GO:0022904)2.71562313
145response to pheromone (GO:0019236)2.70512585
146membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.70042300
147mannosylation (GO:0097502)2.69951472
148negative regulation of amino acid transport (GO:0051956)2.69098434
149substantia nigra development (GO:0021762)2.68889471
150protein targeting to mitochondrion (GO:0006626)2.68877936
151positive regulation of neurotransmitter transport (GO:0051590)2.68547684
152tRNA processing (GO:0008033)2.68238741
153regulation of neurotransmitter levels (GO:0001505)2.67884932
154regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.66196609
155positive regulation of synaptic transmission, GABAergic (GO:0032230)2.65890507
156positive regulation of prostaglandin secretion (GO:0032308)2.65527528
157amino acid import (GO:0043090)2.64308793
158peptidyl-histidine modification (GO:0018202)2.63874773
159regulation of synaptic transmission, glutamatergic (GO:0051966)2.62580464
160hydrogen ion transmembrane transport (GO:1902600)2.58710687
161establishment of protein localization to mitochondrion (GO:0072655)2.57378274
162regulation of mitochondrial translation (GO:0070129)2.56681048
163transcription elongation from RNA polymerase III promoter (GO:0006385)2.55130982
164termination of RNA polymerase III transcription (GO:0006386)2.55130982
165C-terminal protein lipidation (GO:0006501)2.54511763
166DNA deamination (GO:0045006)2.52861471
167guanosine-containing compound biosynthetic process (GO:1901070)2.49076451
168pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.47494011
169establishment of protein localization to mitochondrial membrane (GO:0090151)2.46684858
170GPI anchor biosynthetic process (GO:0006506)2.46490734
171C-terminal protein amino acid modification (GO:0018410)2.46121382
172proton transport (GO:0015992)2.45391726
173pyrimidine nucleotide catabolic process (GO:0006244)2.44855927
174protein localization to mitochondrion (GO:0070585)2.44599284
175sensory perception of taste (GO:0050909)2.43829382
176positive regulation of protein homooligomerization (GO:0032464)2.43067352
177hydrogen transport (GO:0006818)2.42727659
178CTP metabolic process (GO:0046036)2.41512376
179CTP biosynthetic process (GO:0006241)2.41512376
180piRNA metabolic process (GO:0034587)2.40642418
181maturation of 5.8S rRNA (GO:0000460)2.39368438
182purine nucleoside triphosphate biosynthetic process (GO:0009145)2.35508375
183serine transport (GO:0032329)2.35408241
184purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.33149871
185detection of light stimulus involved in sensory perception (GO:0050962)2.32647049
186detection of light stimulus involved in visual perception (GO:0050908)2.32647049
187tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.32449710
188RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.32449710
189C4-dicarboxylate transport (GO:0015740)2.32070165
190anterograde axon cargo transport (GO:0008089)2.31640286

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.13352325
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.05628282
3EZH2_22144423_ChIP-Seq_EOC_Human4.98788779
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.64490631
5GBX2_23144817_ChIP-Seq_PC3_Human3.48688690
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.09461611
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08456993
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06205445
9* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02917571
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72787294
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72787294
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68989732
13* EZH2_27304074_Chip-Seq_ESCs_Mouse2.68948235
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.65038890
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.61449795
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.58988747
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57577540
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55628075
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54636014
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.46265191
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.44425283
22DROSHA_22980978_ChIP-Seq_HELA_Human2.43692423
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42002051
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.41111020
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.38824298
26GABP_17652178_ChIP-ChIP_JURKAT_Human2.37566830
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35099948
28* EZH2_27294783_Chip-Seq_ESCs_Mouse2.34649674
29REST_21632747_ChIP-Seq_MESCs_Mouse2.31680163
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.24115901
31* RARB_27405468_Chip-Seq_BRAIN_Mouse2.21641995
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.12420982
33AR_21572438_ChIP-Seq_LNCaP_Human2.09731512
34THAP11_20581084_ChIP-Seq_MESCs_Mouse2.09296292
35GABP_19822575_ChIP-Seq_HepG2_Human1.98951672
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.93879806
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.89326118
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.80192727
39TAF15_26573619_Chip-Seq_HEK293_Human1.78446202
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.77928193
41XRN2_22483619_ChIP-Seq_HELA_Human1.77878185
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75601210
43P68_20966046_ChIP-Seq_HELA_Human1.75486860
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73467397
45E2F1_20622854_ChIP-Seq_HELA_Human1.72604384
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69118682
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68669558
48PHF8_20622854_ChIP-Seq_HELA_Human1.66178299
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65462253
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59441319
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.59401416
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.59254276
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59145857
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.56929059
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54023647
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50899399
57DCP1A_22483619_ChIP-Seq_HELA_Human1.49494458
58SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.46586343
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46487642
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45987077
61RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.45567220
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.43623831
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42783028
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42513579
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41995156
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.41277409
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.40787652
68SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.40280535
69VDR_23849224_ChIP-Seq_CD4+_Human1.39909811
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.37465546
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36999475
72CTCF_18555785_ChIP-Seq_MESCs_Mouse1.35628028
73BCL6_27268052_Chip-Seq_Bcells_Human1.35088104
74* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33941639
75* RING1B_27294783_Chip-Seq_ESCs_Mouse1.33619495
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33336201
77SMAD4_21799915_ChIP-Seq_A2780_Human1.32632612
78ERA_21632823_ChIP-Seq_H3396_Human1.31164829
79* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.30339653
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29135064
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28677469
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28354168
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27365518
84P300_19829295_ChIP-Seq_ESCs_Human1.26636067
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.25650610
86* FOXP1_21924763_ChIP-Seq_HESCs_Human1.24096454
87CTCF_20526341_ChIP-Seq_ESCs_Human1.23854241
88TP53_22573176_ChIP-Seq_HFKS_Human1.23726129
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.23583250
90ZNF274_21170338_ChIP-Seq_K562_Hela1.23220339
91* RING1B_27294783_Chip-Seq_NPCs_Mouse1.21566922
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21508377
93RAC3_21632823_ChIP-Seq_H3396_Human1.20146980
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19884405
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19720136
96P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19187620
97MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18727452
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18633771
99IGF1R_20145208_ChIP-Seq_DFB_Human1.18549673
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.18306652
101BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.17651306
102SMC4_20622854_ChIP-Seq_HELA_Human1.17495547
103FUS_26573619_Chip-Seq_HEK293_Human1.16996405
104CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.16565745
105BCOR_27268052_Chip-Seq_Bcells_Human1.15755133
106WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15292854
107* RARB_24833708_ChIP-Seq_LIVER_Mouse1.15214520
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14877800
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14755016
110SOX2_21211035_ChIP-Seq_LN229_Gbm1.12708073
111GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12645181
112OCT4_20526341_ChIP-Seq_ESCs_Human1.12255634
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12053277
114KDM5A_27292631_Chip-Seq_BREAST_Human1.11334486
115MYC_18940864_ChIP-ChIP_HL60_Human1.11216690
116TP53_16413492_ChIP-PET_HCT116_Human1.10783766
117ARNT_22903824_ChIP-Seq_MCF-7_Human1.10591484
118DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10580062
119ZNF263_19887448_ChIP-Seq_K562_Human1.09476849
120TP63_22573176_ChIP-Seq_HFKS_Human1.09406396
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09206892
122CREB1_15753290_ChIP-ChIP_HEK293T_Human1.09172016
123AHR_22903824_ChIP-Seq_MCF-7_Human1.08584745
124NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08540372
125TTF2_22483619_ChIP-Seq_HELA_Human1.07865658
126YY1_22570637_ChIP-Seq_MALME-3M_Human1.07727282
127FOXP3_21729870_ChIP-Seq_TREG_Human1.07306779
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06585324
129VDR_22108803_ChIP-Seq_LS180_Human1.06270109
130PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06219909
131SA1_27219007_Chip-Seq_Bcells_Human1.05972736
132SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04344216
133MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03957395
134GATA3_21878914_ChIP-Seq_MCF-7_Human1.03607179
135CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03459723
136TP53_18474530_ChIP-ChIP_U2OS_Human1.03170269
137RNF2_27304074_Chip-Seq_NSC_Mouse1.03053751
138STAT3_23295773_ChIP-Seq_U87_Human1.02933422
139AR_25329375_ChIP-Seq_VCAP_Human1.02834373
140P53_21459846_ChIP-Seq_SAOS-2_Human1.00419880
141ER_23166858_ChIP-Seq_MCF-7_Human0.99863164
142STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99192216
143HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98603848
144P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98308420
145NANOG_20526341_ChIP-Seq_ESCs_Human0.98286735
146E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98076915
147PRDM14_20953172_ChIP-Seq_ESCs_Human0.97603223
148TAF2_19829295_ChIP-Seq_ESCs_Human0.97278824
149* SA1_27219007_Chip-Seq_ERYTHROID_Human0.97238354
150MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96871068
151MYC_19829295_ChIP-Seq_ESCs_Human0.96779916
152ELF1_20517297_ChIP-Seq_JURKAT_Human0.96654085
153CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96486859
154ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96405561
155TRIM28_21343339_ChIP-Seq_HEK293_Human0.96396241
156MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94989189
157AR_19668381_ChIP-Seq_PC3_Human0.94942132
158RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94808785
159* RARA_24833708_ChIP-Seq_LIVER_Mouse0.94026917
160POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93932369
161ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93844067
162SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93281586
163TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92777932
164RUNX2_22187159_ChIP-Seq_PCA_Human0.92447696
165SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92072381
166AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91591759
167STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91564277
168TET1_21490601_ChIP-Seq_MESCs_Mouse0.91547738
169NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91370477
170TCF4_23295773_ChIP-Seq_U87_Human0.91021518
171RXR_22108803_ChIP-Seq_LS180_Human0.90464204
172UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88865226
173CTCF_27219007_Chip-Seq_Bcells_Human0.87984215
174YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87619440
175TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87559610
176POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87559610
177KDM2B_26808549_Chip-Seq_K562_Human0.86794307
178SMAD3_21741376_ChIP-Seq_HESCs_Human0.86466874
179JUN_21703547_ChIP-Seq_K562_Human0.86114706
180SMAD_19615063_ChIP-ChIP_OVARY_Human0.85887095
181SMAD4_21741376_ChIP-Seq_HESCs_Human0.85813482
182TP53_20018659_ChIP-ChIP_R1E_Mouse0.85752183

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.60363014
2MP0003880_abnormal_central_pattern4.81933389
3MP0004270_analgesia3.75199167
4MP0003635_abnormal_synaptic_transmissio3.64399620
5MP0009745_abnormal_behavioral_response3.12360262
6MP0005423_abnormal_somatic_nervous3.03614956
7MP0002064_seizures2.99783561
8MP0002063_abnormal_learning/memory/cond2.96031754
9MP0001486_abnormal_startle_reflex2.84132655
10MP0001968_abnormal_touch/_nociception2.81566521
11MP0002272_abnormal_nervous_system2.61106656
12MP0002572_abnormal_emotion/affect_behav2.53368410
13MP0009046_muscle_twitch2.46287904
14MP0003329_amyloid_beta_deposits2.33637214
15MP0002734_abnormal_mechanical_nocicepti2.32934905
16MP0001986_abnormal_taste_sensitivity2.31666362
17MP0000920_abnormal_myelination2.26493310
18MP0000778_abnormal_nervous_system2.23909678
19MP0002102_abnormal_ear_morphology2.19108394
20MP0008875_abnormal_xenobiotic_pharmacok2.13626207
21MP0002736_abnormal_nociception_after2.10415763
22MP0009780_abnormal_chondrocyte_physiolo1.94234823
23MP0001905_abnormal_dopamine_level1.93603554
24MP0001440_abnormal_grooming_behavior1.93251187
25MP0001529_abnormal_vocalization1.84002212
26MP0003787_abnormal_imprinting1.83998525
27MP0002909_abnormal_adrenal_gland1.82653443
28MP0004885_abnormal_endolymph1.82358624
29MP0002160_abnormal_reproductive_system1.80337359
30MP0002733_abnormal_thermal_nociception1.79936812
31MP0001919_abnormal_reproductive_system1.77951442
32MP0002822_catalepsy1.77943818
33MP0001501_abnormal_sleep_pattern1.70188657
34MP0001970_abnormal_pain_threshold1.66924219
35MP0002067_abnormal_sensory_capabilities1.65750745
36MP0002184_abnormal_innervation1.63855920
37MP0002653_abnormal_ependyma_morphology1.63065120
38MP0005389_reproductive_system_phenotype1.61384086
39MP0000427_abnormal_hair_cycle1.59942337
40MP0004142_abnormal_muscle_tone1.58985616
41MP0005386_behavior/neurological_phenoty1.58588351
42MP0004924_abnormal_behavior1.58588351
43MP0003690_abnormal_glial_cell1.57535879
44MP0000955_abnormal_spinal_cord1.56707473
45MP0002557_abnormal_social/conspecific_i1.55259759
46MP0004742_abnormal_vestibular_system1.54879603
47MP0003011_delayed_dark_adaptation1.53580211
48MP0002882_abnormal_neuron_morphology1.51223663
49MP0002735_abnormal_chemical_nociception1.50558460
50MP0008569_lethality_at_weaning1.50231280
51MP0001485_abnormal_pinna_reflex1.49566966
52MP0001984_abnormal_olfaction1.49242830
53MP0003121_genomic_imprinting1.44958644
54MP0004811_abnormal_neuron_physiology1.42630259
55MP0002066_abnormal_motor_capabilities/c1.39818789
56MP0006035_abnormal_mitochondrial_morpho1.37439297
57MP0006276_abnormal_autonomic_nervous1.34442868
58MP0003634_abnormal_glial_cell1.34342749
59MP0005623_abnormal_meninges_morphology1.28752158
60MP0001216_abnormal_epidermal_layer1.28531613
61MP0003786_premature_aging1.28408000
62MP0005501_abnormal_skin_physiology1.28201471
63MP0008058_abnormal_DNA_repair1.26609326
64MP0001346_abnormal_lacrimal_gland1.26597222
65MP0005499_abnormal_olfactory_system1.25883411
66MP0005394_taste/olfaction_phenotype1.25883411
67MP0003879_abnormal_hair_cell1.23471201
68MP0005409_darkened_coat_color1.23037212
69MP0002876_abnormal_thyroid_physiology1.22459069
70MP0003633_abnormal_nervous_system1.22009117
71MP0003631_nervous_system_phenotype1.20277951
72MP0005551_abnormal_eye_electrophysiolog1.19088869
73MP0004858_abnormal_nervous_system1.18916585
74MP0003632_abnormal_nervous_system1.18085465
75MP0001502_abnormal_circadian_rhythm1.17702213
76MP0001177_atelectasis1.16904600
77MP0010771_integument_phenotype1.16832982
78MP0002229_neurodegeneration1.16565164
79MP0002098_abnormal_vibrissa_morphology1.14553558
80MP0001188_hyperpigmentation1.12312033
81MP0005171_absent_coat_pigmentation1.11709676
82MP0001764_abnormal_homeostasis1.11133480
83MP0000750_abnormal_muscle_regeneration1.10413429
84MP0000566_synostosis1.10117073
85MP0002152_abnormal_brain_morphology1.09327665
86MP0008789_abnormal_olfactory_epithelium1.06877678
87MP0001963_abnormal_hearing_physiology1.05698167
88MP0002163_abnormal_gland_morphology1.05211580
89MP0000462_abnormal_digestive_system1.03840896
90MP0004043_abnormal_pH_regulation1.03056681
91MP0005646_abnormal_pituitary_gland1.01828269
92MP0000537_abnormal_urethra_morphology0.98810071
93MP0002752_abnormal_somatic_nervous0.98708558
94MP0001299_abnormal_eye_distance/0.98401147
95MP0003938_abnormal_ear_development0.97743180
96MP0003122_maternal_imprinting0.97518636
97MP0000604_amyloidosis0.97125561
98MP0002090_abnormal_vision0.93245911
99MP0000751_myopathy0.92451991
100MP0005645_abnormal_hypothalamus_physiol0.92170440
101MP0006292_abnormal_olfactory_placode0.92134160
102MP0000631_abnormal_neuroendocrine_gland0.91225556
103MP0003315_abnormal_perineum_morphology0.88126067
104MP0000358_abnormal_cell_content/0.85845055
105MP0000678_abnormal_parathyroid_gland0.85369515
106MP0006036_abnormal_mitochondrial_physio0.83898921
107MP0005410_abnormal_fertilization0.83847467
108MP0000026_abnormal_inner_ear0.83810024
109MP0004019_abnormal_vitamin_homeostasis0.83019674
110MP0000377_abnormal_hair_follicle0.82664581
111MP0005379_endocrine/exocrine_gland_phen0.80040856
112MP0010678_abnormal_skin_adnexa0.78058621
113MP0003806_abnormal_nucleotide_metabolis0.78000348
114MP0006072_abnormal_retinal_apoptosis0.76892097
115MP0001661_extended_life_span0.76297491
116MP0003137_abnormal_impulse_conducting0.75390480
117MP0002069_abnormal_eating/drinking_beha0.74786283
118MP0000538_abnormal_urinary_bladder0.73001940
119MP0000762_abnormal_tongue_morphology0.72666963
120MP0009379_abnormal_foot_pigmentation0.71266119
121MP0004381_abnormal_hair_follicle0.70817176
122MP0000579_abnormal_nail_morphology0.70745071
123MP0003646_muscle_fatigue0.68454199
124MP0002295_abnormal_pulmonary_circulatio0.66669778
125MP0002234_abnormal_pharynx_morphology0.66520725
126MP0000383_abnormal_hair_follicle0.65122870
127MP0003075_altered_response_to0.64493635
128MP0005195_abnormal_posterior_eye0.63135981
129MP0008874_decreased_physiological_sensi0.63069243
130MP0001943_abnormal_respiration0.63016945
131MP0003861_abnormal_nervous_system0.62261423
132MP0008872_abnormal_physiological_respon0.61747806
133MP0004233_abnormal_muscle_weight0.61328405
134MP0004085_abnormal_heartbeat0.59514699
135MP0004145_abnormal_muscle_electrophysio0.58848467
136MP0000013_abnormal_adipose_tissue0.56796828
137MP0003950_abnormal_plasma_membrane0.53384835
138MP0000467_abnormal_esophagus_morphology0.52770341
139MP0000647_abnormal_sebaceous_gland0.52066411

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.90657294
2Focal motor seizures (HP:0011153)5.40182825
3Neurofibrillary tangles (HP:0002185)4.64935535
4Fragile nails (HP:0001808)4.54217641
5Focal seizures (HP:0007359)4.38538993
6Cerebral inclusion bodies (HP:0100314)4.10211881
7Epileptic encephalopathy (HP:0200134)3.92235770
8Atonic seizures (HP:0010819)3.89100145
9Degeneration of the lateral corticospinal tracts (HP:0002314)3.88073855
10Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.88073855
11Milia (HP:0001056)3.83917555
12Supranuclear gaze palsy (HP:0000605)3.83506810
13Abnormality of the corticospinal tract (HP:0002492)3.63312576
14Plantar hyperkeratosis (HP:0007556)3.51494254
15Onycholysis (HP:0001806)3.49542578
16Visual hallucinations (HP:0002367)3.40511031
17Retinal dysplasia (HP:0007973)3.39846084
18Aplasia involving bones of the extremities (HP:0009825)3.24173149
19Aplasia involving bones of the upper limbs (HP:0009823)3.24173149
20Aplasia of the phalanges of the hand (HP:0009802)3.24173149
21Termporal pattern (HP:0011008)3.17640998
22Insidious onset (HP:0003587)3.17640998
23Dysmetria (HP:0001310)3.10090933
24Poikiloderma (HP:0001029)3.04372039
25Abnormal mitochondria in muscle tissue (HP:0008316)3.01101182
26Spastic gait (HP:0002064)2.99746331
27Progressive cerebellar ataxia (HP:0002073)2.99578710
28Peripheral hypomyelination (HP:0007182)2.95566569
29Febrile seizures (HP:0002373)2.92270722
30Acute necrotizing encephalopathy (HP:0006965)2.89475476
31Absence seizures (HP:0002121)2.86957992
32Ankle clonus (HP:0011448)2.86240787
33Generalized tonic-clonic seizures (HP:0002069)2.79860129
34Dialeptic seizures (HP:0011146)2.77933813
35Split foot (HP:0001839)2.76283386
36Mitochondrial inheritance (HP:0001427)2.73821279
37Sensory axonal neuropathy (HP:0003390)2.72810715
38Action tremor (HP:0002345)2.70413808
39Mutism (HP:0002300)2.66311596
40Megalencephaly (HP:0001355)2.63782622
41Decreased activity of mitochondrial respiratory chain (HP:0008972)2.62936903
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.62936903
43Increased CSF lactate (HP:0002490)2.62914458
44Akinesia (HP:0002304)2.60230820
45Broad-based gait (HP:0002136)2.60147607
46Squamous cell carcinoma (HP:0002860)2.59391236
47Hepatocellular necrosis (HP:0001404)2.59029709
48Abnormal eating behavior (HP:0100738)2.58610676
49Dysdiadochokinesis (HP:0002075)2.58084571
50Pendular nystagmus (HP:0012043)2.57013044
51Nail dystrophy (HP:0008404)2.54947290
52Intention tremor (HP:0002080)2.54577515
53Urinary bladder sphincter dysfunction (HP:0002839)2.52027190
54Decreased circulating renin level (HP:0003351)2.50598642
55Hepatic necrosis (HP:0002605)2.50302976
56Polyphagia (HP:0002591)2.50047118
57Molar tooth sign on MRI (HP:0002419)2.45935722
58Abnormality of midbrain morphology (HP:0002418)2.45935722
593-Methylglutaconic aciduria (HP:0003535)2.44361067
60Anxiety (HP:0000739)2.43520179
61Synostosis involving the elbow (HP:0003938)2.40469584
62Humeroradial synostosis (HP:0003041)2.40469584
63Hypotrichosis (HP:0001006)2.38490808
64Opisthotonus (HP:0002179)2.38054388
65Abnormality of nail color (HP:0100643)2.37062429
66Type II lissencephaly (HP:0007260)2.35158802
67Alopecia of scalp (HP:0002293)2.34310659
68Acute encephalopathy (HP:0006846)2.33567870
69Poor eye contact (HP:0000817)2.31576171
70Hemiparesis (HP:0001269)2.30269553
71Alacrima (HP:0000522)2.28011101
72Progressive macrocephaly (HP:0004481)2.27085783
73Drooling (HP:0002307)2.26325664
74Excessive salivation (HP:0003781)2.26325664
75Amblyopia (HP:0000646)2.26168794
76Palmoplantar hyperkeratosis (HP:0000972)2.25625289
77Aplasia/hypoplasia of the uterus (HP:0008684)2.25324753
78Lower limb muscle weakness (HP:0007340)2.23742257
79Scanning speech (HP:0002168)2.23511570
80Entropion (HP:0000621)2.23276671
81Parakeratosis (HP:0001036)2.21510411
82Lissencephaly (HP:0001339)2.18244132
83Testicular atrophy (HP:0000029)2.17123431
84Progressive inability to walk (HP:0002505)2.16575391
85Poor suck (HP:0002033)2.16309479
86Thickened helices (HP:0000391)2.16122328
87Truncal ataxia (HP:0002078)2.15825409
88Methylmalonic aciduria (HP:0012120)2.15040616
89Pancreatic cysts (HP:0001737)2.14358530
90Methylmalonic acidemia (HP:0002912)2.13986112
91Onion bulb formation (HP:0003383)2.13183038
92Pachygyria (HP:0001302)2.12627923
93Hyperventilation (HP:0002883)2.10850273
94Impaired vibration sensation in the lower limbs (HP:0002166)2.10027634
95Concave nail (HP:0001598)2.09459924
96Palmar hyperkeratosis (HP:0010765)2.09079876
97Urinary urgency (HP:0000012)2.08705608
98Congenital stationary night blindness (HP:0007642)2.08378621
99Chronic hepatic failure (HP:0100626)2.05669145
100Hypokinesia (HP:0002375)2.04626327
101Impaired social interactions (HP:0000735)2.04231776
102Abnormal social behavior (HP:0012433)2.04231776
103Delusions (HP:0000746)2.03784119
104Torticollis (HP:0000473)2.02495325
105Lactic acidosis (HP:0003128)2.01646591
106Limb dystonia (HP:0002451)2.00019245
107Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.98772248
108Stereotypic behavior (HP:0000733)1.98248086
109Depression (HP:0000716)1.97575243
110Postural instability (HP:0002172)1.97519037
111Optic disc pallor (HP:0000543)1.97196733
112Bowel incontinence (HP:0002607)1.96869382
113Agitation (HP:0000713)1.95564876
114Generalized aminoaciduria (HP:0002909)1.94969750
115Esotropia (HP:0000565)1.94682110
116Sparse eyelashes (HP:0000653)1.94431445
117Generalized myoclonic seizures (HP:0002123)1.94165968
118Oligodontia (HP:0000677)1.93483892
119Increased serum lactate (HP:0002151)1.92867275
120Nephrogenic diabetes insipidus (HP:0009806)1.92346517
121Type I transferrin isoform profile (HP:0003642)1.91796023
122Hypoplasia of the uterus (HP:0000013)1.91577857
123Abnormal protein glycosylation (HP:0012346)1.90890898
124Abnormal glycosylation (HP:0012345)1.90890898
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90890898
126Abnormal protein N-linked glycosylation (HP:0012347)1.90890898
127Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90570668
128Epileptiform EEG discharges (HP:0011182)1.90030894
129Medial flaring of the eyebrow (HP:0010747)1.90003569
130Thick nail (HP:0001805)1.89141106
131Aplasia/Hypoplasia of the brainstem (HP:0007362)1.89059059
132Hypoplasia of the brainstem (HP:0002365)1.89059059
133Duplicated collecting system (HP:0000081)1.88127489
134Bony spicule pigmentary retinopathy (HP:0007737)1.87080806
135Renal Fanconi syndrome (HP:0001994)1.86505490
136Abnormality of the renal collecting system (HP:0004742)1.85940769
137Sparse scalp hair (HP:0002209)1.85514101
138Abnormal hair laboratory examination (HP:0003328)1.84986432
139Gaze-evoked nystagmus (HP:0000640)1.84968406
140Rib fusion (HP:0000902)1.83749970
141Cheilitis (HP:0100825)1.83448801
142Congenital primary aphakia (HP:0007707)1.83380404
143Congenital ichthyosiform erythroderma (HP:0007431)1.83283208
144Atrophic scars (HP:0001075)1.83154000
145Diplopia (HP:0000651)1.83093456
146Abnormality of binocular vision (HP:0011514)1.83093456
147True hermaphroditism (HP:0010459)1.82642463
148Inability to walk (HP:0002540)1.82559934
149Lower limb amyotrophy (HP:0007210)1.82550920
150Dry hair (HP:0011359)1.82423165
151EEG with generalized epileptiform discharges (HP:0011198)1.82258329
152Mixed hearing impairment (HP:0000410)1.81158102
153Fetal akinesia sequence (HP:0001989)1.80632506
154Nephronophthisis (HP:0000090)1.80138192
155Ridged nail (HP:0001807)1.79489416
156Abnormality of placental membranes (HP:0011409)1.79034289
157Amniotic constriction ring (HP:0009775)1.79034289
158Increased hepatocellular lipid droplets (HP:0006565)1.78724811
159Coronal craniosynostosis (HP:0004440)1.77941868
160Decreased lacrimation (HP:0000633)1.77940335
161Pancreatic fibrosis (HP:0100732)1.77446969
162Hypoplastic nipples (HP:0002557)1.76669020
163Increased circulating renin level (HP:0000848)1.76261123
164Attenuation of retinal blood vessels (HP:0007843)1.75925725
165Abnormal large intestine physiology (HP:0012700)1.74787696
166Pili torti (HP:0003777)1.74699246
167Microretrognathia (HP:0000308)1.74386233
168Increased intramyocellular lipid droplets (HP:0012240)1.73530378
169Buphthalmos (HP:0000557)1.73272240
170Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.72952397
171Lipid accumulation in hepatocytes (HP:0006561)1.72949373
172Hypsarrhythmia (HP:0002521)1.72596506
173Oligodactyly (hands) (HP:0001180)1.72276862
174Brittle hair (HP:0002299)1.72079885
175Bronchomalacia (HP:0002780)1.71820289
176Death in infancy (HP:0001522)1.71311220
177Absent speech (HP:0001344)1.71278316
178Gait imbalance (HP:0002141)1.70762754
179Severe muscular hypotonia (HP:0006829)1.70027609
180Focal dystonia (HP:0004373)1.68611657
181Hemiplegia (HP:0002301)1.67772071
182Ankyloglossia (HP:0010296)1.67374991
183Abnormality of salivation (HP:0100755)1.66759722
184Morphological abnormality of the pyramidal tract (HP:0002062)1.65896483
185Partial agenesis of the corpus callosum (HP:0001338)1.65783044
186Steppage gait (HP:0003376)1.65687674
187Neuronal loss in central nervous system (HP:0002529)1.60291169
188Cupped ear (HP:0000378)1.60046375
189Aqueductal stenosis (HP:0002410)1.59931445

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.17083934
2EPHA43.57607863
3MAP3K93.23099809
4MARK13.22283440
5NTRK33.00926622
6CAMKK22.99725748
7BCKDK2.86132954
8STK392.85887856
9OXSR12.66263338
10PAK62.59897946
11WNK32.53251691
12PIM22.42340150
13CDK192.40673747
14EPHA22.33120029
15TNIK2.22238994
16DAPK22.19600589
17TRIM282.08210703
18CASK2.06329984
19MAP3K42.04005171
20TESK21.94294736
21MINK11.91345513
22NTRK11.84162133
23PINK11.81409049
24UHMK11.81329591
25NTRK21.76587550
26PNCK1.76195833
27FLT31.74370651
28BCR1.62867241
29PLK21.61721704
30CDK51.58865645
31KSR21.58342187
32BMPR1B1.57177195
33ARAF1.56059713
34PRPF4B1.55091510
35TLK11.54562461
36MAP2K71.49317611
37TYRO31.40082838
38MAPK131.33645538
39ZAK1.33060626
40FGR1.30472959
41STK161.29868267
42BUB11.26555419
43MST1R1.26223522
44CSNK1G21.25816077
45CAMK2B1.25241878
46PHKG21.22411699
47PHKG11.22411699
48PKN11.21054297
49FGFR21.21003631
50MUSK1.19204503
51PRKD21.19027575
52GRK51.18902389
53PRKCI1.17939210
54PAK31.17619430
55CDK141.17002894
56EPHB11.16793647
57MAP3K131.16056501
58WNK41.15882856
59CAMK2A1.15337745
60MAP2K61.15222790
61MAPKAPK51.14544388
62CDK151.12969463
63MAP3K61.11576907
64PRKD31.11137209
65CDK181.09384096
66FRK1.08723393
67LIMK11.05916033
68KSR11.04375781
69ABL21.01908019
70MAP2K41.00571009
71CSNK1G31.00404806
72CDK11A0.99443944
73CSNK1A1L0.96319178
74STK110.92514653
75EPHA30.92433278
76LATS20.91928201
77ROCK20.91338871
78MAPKAPK30.90796426
79SIK20.90129545
80PRKCG0.89965196
81MARK20.88993304
82NEK60.88531750
83TAOK10.87913406
84MAPK150.87045406
85MAP3K20.86518503
86CAMK2D0.85916603
87FES0.85912463
88CAMKK10.85789706
89NME10.84953798
90SRPK10.84546385
91MAP3K120.84126133
92TESK10.83113141
93PTK2B0.82033333
94RIPK40.81385681
95PRKCE0.80978389
96SGK2230.80674303
97SGK4940.80674303
98GRK10.79268519
99WNK10.73836874
100DYRK1A0.73662636
101CAMK2G0.71919958
102AURKA0.67237386
103DYRK20.65944591
104RPS6KA40.65877710
105CSNK1G10.65533835
106NME20.65383419
107DYRK30.64252210
108CAMK10.64018280
109ICK0.61558110
110MET0.61514636
111TAOK30.60828100
112CAMK40.60602574
113RAF10.60525990
114DMPK0.59379484
115DDR20.58276482
116FYN0.56279883
117PRKCH0.56236834
118EPHB20.55679144
119BRAF0.53621059
120MAP3K110.53353108
121MAP2K10.51433978
122PDPK10.50677720
123RPS6KA50.49187114
124SGK10.48921901
125STK380.47907514
126LMTK20.46573727
127MOS0.46541482
128GRK70.46483605
129ADRBK20.46479942
130DAPK10.46041054
131ADRBK10.45096872
132PRKCZ0.43941514
133FER0.43467770
134SIK30.41842936
135RET0.41578340
136PTK20.40259285
137BRSK10.40034940
138MAP3K10.39505304
139RPS6KA20.39314981
140BMPR20.39202591
141PRKG10.39085830
142CSNK1A10.37608852
143PLK10.37274935
144PRKACA0.34354879
145INSRR0.33836096
146PRKAA10.32900997

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041224.32655894
2Nicotine addiction_Homo sapiens_hsa050333.41913265
3Synaptic vesicle cycle_Homo sapiens_hsa047213.07843244
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.94948905
5GABAergic synapse_Homo sapiens_hsa047272.67185157
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.60105447
7Glutamatergic synapse_Homo sapiens_hsa047242.57720371
8RNA polymerase_Homo sapiens_hsa030202.48507572
9Circadian entrainment_Homo sapiens_hsa047132.41331792
10Morphine addiction_Homo sapiens_hsa050322.34071477
11Protein export_Homo sapiens_hsa030602.11997554
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.04593900
13Long-term potentiation_Homo sapiens_hsa047202.04145415
14Salivary secretion_Homo sapiens_hsa049702.03550941
15Axon guidance_Homo sapiens_hsa043601.99649488
16Proteasome_Homo sapiens_hsa030501.97769022
17Amphetamine addiction_Homo sapiens_hsa050311.95150795
18Olfactory transduction_Homo sapiens_hsa047401.94945195
19Serotonergic synapse_Homo sapiens_hsa047261.94767082
20Dopaminergic synapse_Homo sapiens_hsa047281.92059852
21Collecting duct acid secretion_Homo sapiens_hsa049661.91943009
22Folate biosynthesis_Homo sapiens_hsa007901.82375228
23Regulation of autophagy_Homo sapiens_hsa041401.80897195
24Cholinergic synapse_Homo sapiens_hsa047251.79682432
25Long-term depression_Homo sapiens_hsa047301.72730807
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.72492874
27Gastric acid secretion_Homo sapiens_hsa049711.67179069
28Insulin secretion_Homo sapiens_hsa049111.60684346
29Cocaine addiction_Homo sapiens_hsa050301.58254383
30Renin secretion_Homo sapiens_hsa049241.52563017
31Basal transcription factors_Homo sapiens_hsa030221.52389524
32Pyrimidine metabolism_Homo sapiens_hsa002401.50071203
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48947584
34Taste transduction_Homo sapiens_hsa047421.48639386
35Base excision repair_Homo sapiens_hsa034101.47757590
36Oxytocin signaling pathway_Homo sapiens_hsa049211.47395974
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45786057
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42484390
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39710508
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39285009
41Vibrio cholerae infection_Homo sapiens_hsa051101.34902933
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33964542
43Calcium signaling pathway_Homo sapiens_hsa040201.33227766
44Oxidative phosphorylation_Homo sapiens_hsa001901.32816127
45Gap junction_Homo sapiens_hsa045401.29645368
46Fanconi anemia pathway_Homo sapiens_hsa034601.28900991
47GnRH signaling pathway_Homo sapiens_hsa049121.28474564
48Linoleic acid metabolism_Homo sapiens_hsa005911.23952150
49Cardiac muscle contraction_Homo sapiens_hsa042601.22577662
50Fatty acid elongation_Homo sapiens_hsa000621.19923908
51Alzheimers disease_Homo sapiens_hsa050101.15238904
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11812867
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11430558
54Selenocompound metabolism_Homo sapiens_hsa004501.11422047
55Melanogenesis_Homo sapiens_hsa049161.10409627
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10208065
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09998861
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09015185
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07960824
60Steroid biosynthesis_Homo sapiens_hsa001001.07562582
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05101863
62Ether lipid metabolism_Homo sapiens_hsa005651.04947291
63ErbB signaling pathway_Homo sapiens_hsa040121.04320286
64Ribosome_Homo sapiens_hsa030100.99713240
65cAMP signaling pathway_Homo sapiens_hsa040240.99285332
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.97743884
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96552757
68Fructose and mannose metabolism_Homo sapiens_hsa000510.88655738
69Estrogen signaling pathway_Homo sapiens_hsa049150.88532055
70Parkinsons disease_Homo sapiens_hsa050120.88039310
71Nucleotide excision repair_Homo sapiens_hsa034200.87073887
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86155100
73Metabolic pathways_Homo sapiens_hsa011000.84725999
74Dilated cardiomyopathy_Homo sapiens_hsa054140.84251885
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.83633858
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82400639
77Renal cell carcinoma_Homo sapiens_hsa052110.80408671
78Dorso-ventral axis formation_Homo sapiens_hsa043200.78795855
79Nitrogen metabolism_Homo sapiens_hsa009100.78411083
80Homologous recombination_Homo sapiens_hsa034400.78345374
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76392443
82Peroxisome_Homo sapiens_hsa041460.76113762
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75876403
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75607339
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74941814
86Ras signaling pathway_Homo sapiens_hsa040140.74536965
87Phototransduction_Homo sapiens_hsa047440.73601025
88Glioma_Homo sapiens_hsa052140.73155383
89Type II diabetes mellitus_Homo sapiens_hsa049300.71854495
90Tight junction_Homo sapiens_hsa045300.71092415
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70756136
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.70183977
93MAPK signaling pathway_Homo sapiens_hsa040100.68383019
94Caffeine metabolism_Homo sapiens_hsa002320.67856376
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67054690
96Vitamin digestion and absorption_Homo sapiens_hsa049770.66148700
97Choline metabolism in cancer_Homo sapiens_hsa052310.64434859
98Pancreatic secretion_Homo sapiens_hsa049720.64238646
99Purine metabolism_Homo sapiens_hsa002300.64013791
100RNA degradation_Homo sapiens_hsa030180.63339753
101Endocytosis_Homo sapiens_hsa041440.62405936
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.62245497
103Hedgehog signaling pathway_Homo sapiens_hsa043400.60037601
104Arginine and proline metabolism_Homo sapiens_hsa003300.59530444
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58507458
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56761321
107Thyroid hormone synthesis_Homo sapiens_hsa049180.55437384
108Butanoate metabolism_Homo sapiens_hsa006500.55050281
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54103086
110One carbon pool by folate_Homo sapiens_hsa006700.53960693
111VEGF signaling pathway_Homo sapiens_hsa043700.52752847
112Wnt signaling pathway_Homo sapiens_hsa043100.52266413
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52207015
114Rap1 signaling pathway_Homo sapiens_hsa040150.52083387
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51901472
116Rheumatoid arthritis_Homo sapiens_hsa053230.51616763
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50895722
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.50815660
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50452490
120Alcoholism_Homo sapiens_hsa050340.50340365
121Huntingtons disease_Homo sapiens_hsa050160.49612330
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49434278
123Phenylalanine metabolism_Homo sapiens_hsa003600.49276434
124Ovarian steroidogenesis_Homo sapiens_hsa049130.49055700
125p53 signaling pathway_Homo sapiens_hsa041150.48219399
126N-Glycan biosynthesis_Homo sapiens_hsa005100.48198716
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48064574
128Sphingolipid metabolism_Homo sapiens_hsa006000.46244089
129Tryptophan metabolism_Homo sapiens_hsa003800.46186948
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45676824
131Sulfur metabolism_Homo sapiens_hsa009200.44963369
132Oocyte meiosis_Homo sapiens_hsa041140.44615815
133Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44605381
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42162332
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.41106295
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40931545
137Chemical carcinogenesis_Homo sapiens_hsa052040.39858838
138Prion diseases_Homo sapiens_hsa050200.39467060
139Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39327095
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38249278
141Circadian rhythm_Homo sapiens_hsa047100.37582787
142Galactose metabolism_Homo sapiens_hsa000520.37428829
143Inositol phosphate metabolism_Homo sapiens_hsa005620.33080236
144Glutathione metabolism_Homo sapiens_hsa004800.33016756
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32896529
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32405129
147Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29693659
148Biosynthesis of amino acids_Homo sapiens_hsa012300.29511904
149Hippo signaling pathway_Homo sapiens_hsa043900.28934671
150Steroid hormone biosynthesis_Homo sapiens_hsa001400.28206753

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