DLL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1forebrain neuron differentiation (GO:0021879)9.16418051
2cerebral cortex neuron differentiation (GO:0021895)9.00380502
3dopaminergic neuron differentiation (GO:0071542)8.92199921
4spinal cord association neuron differentiation (GO:0021527)8.77499481
5ganglion development (GO:0061548)8.03809819
6lung secretory cell differentiation (GO:0061140)6.98142714
7pyrimidine nucleobase catabolic process (GO:0006208)6.65532475
8regulation of timing of cell differentiation (GO:0048505)6.23335702
9limb bud formation (GO:0060174)6.13812253
10axon extension involved in axon guidance (GO:0048846)5.93664189
11neuron projection extension involved in neuron projection guidance (GO:1902284)5.93664189
12Notch signaling involved in heart development (GO:0061314)5.92136288
13face development (GO:0060324)5.72990660
14epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.71832037
15* positive regulation of Notch signaling pathway (GO:0045747)5.68678416
16behavioral response to nicotine (GO:0035095)5.68044297
17endocardial cushion morphogenesis (GO:0003203)5.53160428
18positive regulation of neuroblast proliferation (GO:0002052)5.50379940
19lateral sprouting from an epithelium (GO:0060601)5.29224826
20negative regulation of axon guidance (GO:1902668)5.25157508
21paraxial mesoderm development (GO:0048339)5.24964673
22nucleobase catabolic process (GO:0046113)5.17707138
23response to folic acid (GO:0051593)5.04578003
24heart valve formation (GO:0003188)4.98976859
25cell surface receptor signaling pathway involved in heart development (GO:0061311)4.92208171
26ventricular trabecula myocardium morphogenesis (GO:0003222)4.87712028
27glial cell proliferation (GO:0014009)4.85457599
28auditory receptor cell differentiation (GO:0042491)4.85351554
29creatine metabolic process (GO:0006600)4.83306354
30epithelial cell differentiation involved in prostate gland development (GO:0060742)4.83213222
31planar cell polarity pathway involved in neural tube closure (GO:0090179)4.78560066
32* neuronal stem cell maintenance (GO:0097150)4.78277669
33primitive streak formation (GO:0090009)4.76955443
34lung epithelium development (GO:0060428)4.74184713
35negative regulation of axon extension involved in axon guidance (GO:0048843)4.71514922
36cell differentiation in spinal cord (GO:0021515)4.70727791
37olfactory bulb development (GO:0021772)4.70080818
38negative regulation of oligodendrocyte differentiation (GO:0048715)4.69110128
39cardiac ventricle formation (GO:0003211)4.60714628
40epithelial cell fate commitment (GO:0072148)4.41326112
41regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.38699706
42regulation of somitogenesis (GO:0014807)4.37070768
43mesenchyme morphogenesis (GO:0072132)4.23756994
44glomerular filtration (GO:0003094)4.22826262
45positive regulation of neural precursor cell proliferation (GO:2000179)4.13690676
46kidney morphogenesis (GO:0060993)4.13073204
47regulation of axon guidance (GO:1902667)4.08274521
48cardiac chamber formation (GO:0003207)4.07963599
49hippocampus development (GO:0021766)4.04672636
50embryonic foregut morphogenesis (GO:0048617)4.04219471
51midgut development (GO:0007494)4.03353170
52heart trabecula morphogenesis (GO:0061384)4.03128649
53establishment of tissue polarity (GO:0007164)4.01091681
54establishment of planar polarity (GO:0001736)4.01091681
55positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.94584467
56neuron fate specification (GO:0048665)3.92751636
57neuron fate determination (GO:0048664)3.91799642
58musculoskeletal movement (GO:0050881)3.90220451
59multicellular organismal movement (GO:0050879)3.90220451
60renal filtration (GO:0097205)3.90101932
61calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.88504921
62ventricular septum morphogenesis (GO:0060412)3.88354872
63cerebral cortex cell migration (GO:0021795)3.87491483
64renal system development (GO:0072001)3.82252209
65collecting duct development (GO:0072044)3.81087366
66cardiac right ventricle morphogenesis (GO:0003215)3.78505947
67cardiac ventricle morphogenesis (GO:0003208)3.78407064
68activation of MAPKKK activity (GO:0000185)3.74465007
69* regulation of Notch signaling pathway (GO:0008593)3.73475098
70regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.73207471
71microtubule depolymerization (GO:0007019)3.73154754
72regulation of neuroblast proliferation (GO:1902692)3.70682589
73appendage development (GO:0048736)3.64001291
74limb development (GO:0060173)3.64001291
75positive regulation of p38MAPK cascade (GO:1900745)3.63967587
76positive regulation of gastrulation (GO:2000543)3.63963788
77negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.61538442
78negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.60562839
79regulation of axon extension involved in axon guidance (GO:0048841)3.60504572
80dendritic spine morphogenesis (GO:0060997)3.59184553
81oligodendrocyte differentiation (GO:0048709)3.51877850
82establishment of nucleus localization (GO:0040023)3.51056153
83astrocyte differentiation (GO:0048708)3.50732100
84intraciliary transport (GO:0042073)3.50444057
85nonmotile primary cilium assembly (GO:0035058)3.50128336
86spinal cord development (GO:0021510)3.49903669
87cardiac chamber morphogenesis (GO:0003206)3.49127471
88lung cell differentiation (GO:0060479)3.45801955
89lung epithelial cell differentiation (GO:0060487)3.45393423
90somite development (GO:0061053)3.45072556
91substrate-independent telencephalic tangential migration (GO:0021826)3.44380401
92substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.44380401
93trabecula morphogenesis (GO:0061383)3.43570798
94midbrain development (GO:0030901)3.41027532
95thalamus development (GO:0021794)3.40489102
96regulation of oligodendrocyte differentiation (GO:0048713)3.40011088
97lung-associated mesenchyme development (GO:0060484)3.36847736
98axonal fasciculation (GO:0007413)3.36258445
99negative regulation of axon extension (GO:0030517)3.33728773
100heart valve morphogenesis (GO:0003179)3.33707084
101axon ensheathment in central nervous system (GO:0032291)3.33371951
102central nervous system myelination (GO:0022010)3.33371951
103central nervous system neuron differentiation (GO:0021953)3.32553827
104sequestering of actin monomers (GO:0042989)3.30914569
105neuron fate commitment (GO:0048663)3.30643822
106developmental induction (GO:0031128)3.30253393
107cerebral cortex radially oriented cell migration (GO:0021799)3.29927293
108glandular epithelial cell differentiation (GO:0002067)3.29500206
109regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.29111194
110suckling behavior (GO:0001967)3.25726349
111lens fiber cell development (GO:0070307)3.25431415
112epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.24763643
113central nervous system projection neuron axonogenesis (GO:0021952)3.24303375
114respiratory tube development (GO:0030323)3.23634318
115cell-cell signaling involved in cell fate commitment (GO:0045168)3.23605131
116positive regulation of BMP signaling pathway (GO:0030513)3.23018556
117neural tube formation (GO:0001841)3.20672515
118positive regulation of astrocyte differentiation (GO:0048711)3.18363843
119photoreceptor cell differentiation (GO:0046530)3.18295075
120eye photoreceptor cell differentiation (GO:0001754)3.18295075
121reflex (GO:0060004)3.17987585
122cochlea morphogenesis (GO:0090103)3.17584246
123oligodendrocyte development (GO:0014003)3.16799015
124negative regulation of glial cell differentiation (GO:0045686)3.16213123
125positive regulation of oligodendrocyte differentiation (GO:0048714)3.16123888
126pituitary gland development (GO:0021983)3.15041620
127negative regulation of astrocyte differentiation (GO:0048712)3.14181711
128cell fate specification (GO:0001708)3.12432678
129positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.11045589
130mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.11045589
131notochord development (GO:0030903)3.10936672
132endothelial cell differentiation (GO:0045446)3.10564083
133telencephalon cell migration (GO:0022029)3.08586108
134atrial septum morphogenesis (GO:0060413)3.08326393
135regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.07771461
136layer formation in cerebral cortex (GO:0021819)3.07472373
137regulation of growth hormone secretion (GO:0060123)3.07453583
138cardiac epithelial to mesenchymal transition (GO:0060317)3.06456358
139central nervous system neuron development (GO:0021954)3.05942004
140positive regulation of circadian rhythm (GO:0042753)3.05361093
141positive regulation of receptor biosynthetic process (GO:0010870)3.05145685
142glomerular basement membrane development (GO:0032836)3.04850119
143synaptic transmission, cholinergic (GO:0007271)3.04489941
144G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.04308933
145negative regulation of glial cell proliferation (GO:0060253)3.03398171
146somite rostral/caudal axis specification (GO:0032525)3.02862000
147sympathetic nervous system development (GO:0048485)3.01097318
148embryonic hindlimb morphogenesis (GO:0035116)3.00266108
149regulation of astrocyte differentiation (GO:0048710)2.99791861
150retinal ganglion cell axon guidance (GO:0031290)2.98279222
151* cell fate determination (GO:0001709)2.97642550
152Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.97440747
153negative regulation of Notch signaling pathway (GO:0045746)2.96225008
154cellular anion homeostasis (GO:0030002)2.96046820
155hair cell differentiation (GO:0035315)2.95244376
156cell migration involved in heart development (GO:0060973)2.94206202
157neuroblast proliferation (GO:0007405)2.92083071
158positive regulation of mitochondrial fission (GO:0090141)2.91643552
159lung lobe morphogenesis (GO:0060463)2.90925259
160multicellular organismal aging (GO:0010259)2.90666701
161forebrain cell migration (GO:0021885)2.89697660
162negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.86678482
163hypothalamus development (GO:0021854)2.86372044
164regulation of development, heterochronic (GO:0040034)2.86343572
165negative chemotaxis (GO:0050919)2.86088184
166neural precursor cell proliferation (GO:0061351)2.85263682
167epithelial cilium movement (GO:0003351)2.85146098
168negative regulation of epithelial to mesenchymal transition (GO:0010719)2.83407959
169neuron recognition (GO:0008038)2.82546723
170epithelial tube branching involved in lung morphogenesis (GO:0060441)2.80050750
171ephrin receptor signaling pathway (GO:0048013)2.79974795
172growth hormone secretion (GO:0030252)2.79600155
173neural nucleus development (GO:0048857)2.79132688
174neuron migration (GO:0001764)2.78706989

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.52424568
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.99707771
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.36438983
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.86057008
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.68109318
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.13733806
7* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse3.08180095
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.01965710
9* EZH2_27304074_Chip-Seq_ESCs_Mouse2.92943013
10* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.87456054
11* EED_16625203_ChIP-ChIP_MESCs_Mouse2.78495630
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.64093034
13* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55677675
14* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55677675
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.53300591
16TP53_20018659_ChIP-ChIP_R1E_Mouse2.41887815
17* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.41847004
18* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.31229209
19* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.25487570
20* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.24808953
21* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20732906
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17123630
23* OLIG2_26023283_ChIP-Seq_AINV15_Mouse2.15350297
24SOX2_18555785_ChIP-Seq_MESCs_Mouse2.13342883
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.10516071
26ZNF274_21170338_ChIP-Seq_K562_Hela2.08372408
27* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.03276859
28IGF1R_20145208_ChIP-Seq_DFB_Human2.01637782
29* RING1B_27294783_Chip-Seq_NPCs_Mouse1.99508771
30* EZH2_27294783_Chip-Seq_ESCs_Mouse1.98570112
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.98514724
32* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95711897
33* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.93886307
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.90573328
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.90573328
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.90573328
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88163693
38* RING1B_27294783_Chip-Seq_ESCs_Mouse1.88103459
39* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87641950
40CDX2_20551321_ChIP-Seq_CACO-2_Human1.87500379
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87451313
42* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.79778471
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.76227128
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.75476666
45* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.73652991
46IRF1_19129219_ChIP-ChIP_H3396_Human1.72267278
47* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.69822630
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69631152
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67516576
50* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.67247536
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66422988
52* SOX2_16153702_ChIP-ChIP_HESCs_Human1.65675498
53EGR1_19032775_ChIP-ChIP_M12_Human1.65407525
54* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.58801584
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51881134
56CLOCK_20551151_ChIP-Seq_293T_Human1.50748357
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.49416178
58* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.42790785
59* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.42692935
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41607424
61* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.41112044
62* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39205338
63ISL1_27105846_Chip-Seq_CPCs_Mouse1.38586061
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38097360
65* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37608646
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35007502
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32787322
68* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.32478052
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29722349
70* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.29624718
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28888141
72REST_21632747_ChIP-Seq_MESCs_Mouse1.28850429
73* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.27813713
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26040352
75* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24474973
76* KDM2B_26808549_Chip-Seq_K562_Human1.22550140
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19057837
78TAF15_26573619_Chip-Seq_HEK293_Human1.18627667
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16475827
80REST_18959480_ChIP-ChIP_MESCs_Mouse1.14396137
81AR_21572438_ChIP-Seq_LNCaP_Human1.13917520
82* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.12494722
83FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11945832
84RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10129313
85* KDM2B_26808549_Chip-Seq_JURKAT_Human1.10011399
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09776979
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08924754
88GATA1_26923725_Chip-Seq_HPCs_Mouse1.08443762
89NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08402649
90POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08381754
91* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07316726
92GBX2_23144817_ChIP-Seq_PC3_Human1.06238926
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06192518
94ZNF263_19887448_ChIP-Seq_K562_Human1.05250854
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04916600
96* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.04753546
97GABP_17652178_ChIP-ChIP_JURKAT_Human1.04237377
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04123465
99AR_21909140_ChIP-Seq_LNCAP_Human1.02060113
100ELK4_26923725_Chip-Seq_MESODERM_Mouse1.01311551
101CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01169207
102* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00591772
103SALL1_21062744_ChIP-ChIP_HESCs_Human1.00439139
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.00234861
105WDR5_24793694_ChIP-Seq_LNCAP_Human1.00139983
106MYC_18940864_ChIP-ChIP_HL60_Human0.99906231
107* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98590415
108EGR1_19374776_ChIP-ChIP_THP-1_Human0.98321222
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97965926
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97563713
111SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97524492
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97384611
113ERG_21242973_ChIP-ChIP_JURKAT_Human0.97273698
114KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97172328
115TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96718450
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96658842
117TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96406601
118P300_19829295_ChIP-Seq_ESCs_Human0.93729438
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92652765
120* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91968149
121* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91760382
122* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91686460
123STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91495002
124* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.91292785
125SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.90530411
126ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89855583
127* SOX3_22085726_ChIP-Seq_NPCs_Mouse0.89690223
128DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89025361
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88734397
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88734397
131TAL1_26923725_Chip-Seq_HPCs_Mouse0.88418460
132OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88356405
133NANOG_16153702_ChIP-ChIP_HESCs_Human0.88097898
134* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.87832447
135* ESR2_21235772_ChIP-Seq_MCF-7_Human0.87343960
136* ESR1_21235772_ChIP-Seq_MCF-7_Human0.87100381
137THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86477296
138RXR_22108803_ChIP-Seq_LS180_Human0.86467631
139SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85832799
140HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84731485
141VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83821650
142* KDM2B_26808549_Chip-Seq_DND41_Human0.83299509
143TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82273136
144RNF2_27304074_Chip-Seq_NSC_Mouse0.81807458
145EZH2_22144423_ChIP-Seq_EOC_Human0.81491830
146* RUNX2_22187159_ChIP-Seq_PCA_Human0.81220271
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79423254
148CBP_20019798_ChIP-Seq_JUKART_Human0.77136476

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.27836907
2MP0010030_abnormal_orbit_morphology4.74973685
3MP0000537_abnormal_urethra_morphology3.73001636
4MP0002751_abnormal_autonomic_nervous3.67494200
5MP0002282_abnormal_trachea_morphology3.62659773
6MP0002653_abnormal_ependyma_morphology3.42556884
7MP0002234_abnormal_pharynx_morphology3.02408581
8MP0005171_absent_coat_pigmentation3.01489850
9MP0000467_abnormal_esophagus_morphology2.99102987
10MP0006072_abnormal_retinal_apoptosis2.80220299
11MP0009053_abnormal_anal_canal2.66157234
12MP0008995_early_reproductive_senescence2.58752986
13MP0003283_abnormal_digestive_organ2.49796543
14MP0003122_maternal_imprinting2.29918995
15MP0003938_abnormal_ear_development2.29067404
16MP0003115_abnormal_respiratory_system2.28761892
17MP0003119_abnormal_digestive_system2.22304698
18MP0003937_abnormal_limbs/digits/tail_de2.06540542
19MP0000778_abnormal_nervous_system2.06186973
20MP0002638_abnormal_pupillary_reflex2.05210451
21MP0000049_abnormal_middle_ear2.05013987
22MP0005253_abnormal_eye_physiology1.98384950
23MP0002932_abnormal_joint_morphology1.96961374
24MP0003890_abnormal_embryonic-extraembry1.93504850
25MP0008789_abnormal_olfactory_epithelium1.85981826
26MP0002095_abnormal_skin_pigmentation1.76950408
27MP0002938_white_spotting1.66978419
28MP0003315_abnormal_perineum_morphology1.66590455
29MP0002249_abnormal_larynx_morphology1.65286280
30MP0003385_abnormal_body_wall1.60636020
31* MP0003861_abnormal_nervous_system1.59374651
32MP0005248_abnormal_Harderian_gland1.58477724
33MP0009780_abnormal_chondrocyte_physiolo1.55404931
34MP0002233_abnormal_nose_morphology1.53412487
35MP0000762_abnormal_tongue_morphology1.46783855
36MP0000681_abnormal_thyroid_gland1.46037211
37MP0001286_abnormal_eye_development1.45799171
38MP0002111_abnormal_tail_morphology1.45603281
39MP0005167_abnormal_blood-brain_barrier1.45005267
40MP0001293_anophthalmia1.41885429
41MP0003935_abnormal_craniofacial_develop1.40447604
42MP0000428_abnormal_craniofacial_morphol1.38917107
43MP0003755_abnormal_palate_morphology1.37967829
44MP0002092_abnormal_eye_morphology1.37295294
45MP0002116_abnormal_craniofacial_bone1.36816938
46MP0004885_abnormal_endolymph1.36604450
47MP0000631_abnormal_neuroendocrine_gland1.35428182
48MP0005076_abnormal_cell_differentiation1.33851476
49MP0005499_abnormal_olfactory_system1.32034070
50MP0005394_taste/olfaction_phenotype1.32034070
51MP0010386_abnormal_urinary_bladder1.29573109
52MP0000462_abnormal_digestive_system1.27345369
53MP0002089_abnormal_postnatal_growth/wei1.26409256
54MP0001299_abnormal_eye_distance/1.25801836
55MP0002697_abnormal_eye_size1.23851646
56MP0006276_abnormal_autonomic_nervous1.21346681
57MP0006292_abnormal_olfactory_placode1.20967799
58MP0005646_abnormal_pituitary_gland1.19599297
59MP0008932_abnormal_embryonic_tissue1.19274839
60* MP0002752_abnormal_somatic_nervous1.18464117
61MP0004197_abnormal_fetal_growth/weight/1.18230115
62MP0004811_abnormal_neuron_physiology1.17406059
63MP0000647_abnormal_sebaceous_gland1.16183628
64MP0002557_abnormal_social/conspecific_i1.16008632
65MP0001270_distended_abdomen1.15917567
66MP0001346_abnormal_lacrimal_gland1.15688132
67* MP0002084_abnormal_developmental_patter1.14803613
68* MP0002085_abnormal_embryonic_tissue1.14040800
69MP0010678_abnormal_skin_adnexa1.13803957
70* MP0002882_abnormal_neuron_morphology1.12103506
71MP0001486_abnormal_startle_reflex1.11480301
72MP0000383_abnormal_hair_follicle1.10993851
73MP0002102_abnormal_ear_morphology1.10768978
74MP0003705_abnormal_hypodermis_morpholog1.10001333
75MP0003880_abnormal_central_pattern1.09125716
76MP0005647_abnormal_sex_gland1.06824650
77MP0003942_abnormal_urinary_system1.06395198
78MP0004742_abnormal_vestibular_system1.05606245
79* MP0004133_heterotaxia1.05545275
80* MP0000733_abnormal_muscle_development1.05314860
81* MP0000955_abnormal_spinal_cord1.04611356
82MP0002063_abnormal_learning/memory/cond1.04602430
83MP0005645_abnormal_hypothalamus_physiol1.04208251
84* MP0000026_abnormal_inner_ear1.02418636
85MP0005195_abnormal_posterior_eye1.02065055
86MP0001984_abnormal_olfaction0.99842954
87MP0004859_abnormal_synaptic_plasticity0.99797952
88MP0000432_abnormal_head_morphology0.99608598
89MP0009250_abnormal_appendicular_skeleto0.99489743
90MP0000569_abnormal_digit_pigmentation0.99427592
91MP0005187_abnormal_penis_morphology0.99340815
92MP0002572_abnormal_emotion/affect_behav0.99125210
93MP0002177_abnormal_outer_ear0.96327903
94MP0004142_abnormal_muscle_tone0.96274733
95MP0004270_analgesia0.95752895
96MP0000163_abnormal_cartilage_morphology0.94832912
97MP0000534_abnormal_ureter_morphology0.94201645
98MP0004381_abnormal_hair_follicle0.91891639
99MP0003136_yellow_coat_color0.91192708
100MP0002064_seizures0.90404582
101MP0002098_abnormal_vibrissa_morphology0.89498789
102* MP0002152_abnormal_brain_morphology0.88198578
103MP0003123_paternal_imprinting0.88123169
104MP0005423_abnormal_somatic_nervous0.85912978
105MP0001485_abnormal_pinna_reflex0.85549919
106* MP0002081_perinatal_lethality0.85328160
107MP0000579_abnormal_nail_morphology0.84918862
108MP0004272_abnormal_basement_membrane0.84917358
109MP0003635_abnormal_synaptic_transmissio0.84522600
110MP0005508_abnormal_skeleton_morphology0.84294294
111MP0004858_abnormal_nervous_system0.83612693
112MP0002928_abnormal_bile_duct0.80456983
113MP0005391_vision/eye_phenotype0.79596572
114MP0002184_abnormal_innervation0.79258464
115MP0001730_embryonic_growth_arrest0.78687093
116MP0010234_abnormal_vibrissa_follicle0.77525794
117MP0005381_digestive/alimentary_phenotyp0.77438365
118MP0005360_urolithiasis0.76805624
119MP0004134_abnormal_chest_morphology0.76726670
120* MP0002114_abnormal_axial_skeleton0.76486695
121MP0003941_abnormal_skin_development0.76258455
122MP0003787_abnormal_imprinting0.75772185
123MP0001672_abnormal_embryogenesis/_devel0.75487408
124MP0005380_embryogenesis_phenotype0.75487408
125MP0001340_abnormal_eyelid_morphology0.74573404
126MP0010368_abnormal_lymphatic_system0.73819323
127MP0002088_abnormal_embryonic_growth/wei0.73765304
128MP0001963_abnormal_hearing_physiology0.72873801
129MP0002277_abnormal_respiratory_mucosa0.72723909
130* MP0002925_abnormal_cardiovascular_devel0.71933371
131MP0004084_abnormal_cardiac_muscle0.71690685
132MP0001529_abnormal_vocalization0.71453747
133MP0009745_abnormal_behavioral_response0.71251454
134MP0009379_abnormal_foot_pigmentation0.70981332
135MP0003878_abnormal_ear_physiology0.70804270
136MP0005377_hearing/vestibular/ear_phenot0.70804270
137MP0003984_embryonic_growth_retardation0.70689246
138MP0003634_abnormal_glial_cell0.70621711
139MP0000538_abnormal_urinary_bladder0.70250325
140* MP0002069_abnormal_eating/drinking_beha0.70103553
141MP0004233_abnormal_muscle_weight0.70092232
142MP0001764_abnormal_homeostasis0.68139251
143MP0003121_genomic_imprinting0.67861156
144MP0002734_abnormal_mechanical_nocicepti0.67586928
145MP0001943_abnormal_respiration0.67327657
146MP0001502_abnormal_circadian_rhythm0.66198124
147MP0002272_abnormal_nervous_system0.64742212
148MP0002067_abnormal_sensory_capabilities0.64434585

Predicted human phenotypes

RankGene SetZ-score
1Thyroid-stimulating hormone excess (HP:0002925)6.01515674
2Anomalous pulmonary venous return (HP:0010772)5.78967207
3Neonatal respiratory distress (HP:0002643)5.31737507
4Intestinal atresia (HP:0011100)5.18346019
5Esophageal atresia (HP:0002032)5.07196217
6Abnormality of the pulmonary veins (HP:0011718)5.03241069
7Oligodactyly (hands) (HP:0001180)4.91927070
8Anophthalmia (HP:0000528)4.10427321
9Chin dimple (HP:0010751)4.09128687
10Oligodactyly (HP:0012165)3.92171756
11Chorioretinal atrophy (HP:0000533)3.91012379
12Down-sloping shoulders (HP:0200021)3.90411579
13Vitreoretinal degeneration (HP:0000655)3.84581551
14Coronal craniosynostosis (HP:0004440)3.63905219
15Labial hypoplasia (HP:0000066)3.56099224
16Meningocele (HP:0002435)3.55180154
17Hepatoblastoma (HP:0002884)3.42262534
18Abnormality of the parathyroid morphology (HP:0011766)3.38219250
19Aqueductal stenosis (HP:0002410)3.37010293
20Alacrima (HP:0000522)3.34320093
21Septo-optic dysplasia (HP:0100842)3.31685365
22Gastrointestinal atresia (HP:0002589)3.26489493
23Hypoplastic female external genitalia (HP:0012815)3.22466938
24Disproportionate short-trunk short stature (HP:0003521)3.15666656
25Congenital malformation of the right heart (HP:0011723)3.12197823
26Double outlet right ventricle (HP:0001719)3.12197823
27Maternal diabetes (HP:0009800)3.09703538
28Bifid scrotum (HP:0000048)3.01793410
29Decreased lacrimation (HP:0000633)2.98470957
30Renal dysplasia (HP:0000110)2.93573322
31Germ cell neoplasia (HP:0100728)2.93151490
32Anterior segment dysgenesis (HP:0007700)2.92431068
33Abnormality of the right ventricle (HP:0001707)2.92296947
34Supernumerary ribs (HP:0005815)2.91779147
35Pulmonary artery stenosis (HP:0004415)2.91665532
36Pendular nystagmus (HP:0012043)2.90024559
37Gait imbalance (HP:0002141)2.87897447
38Hemivertebrae (HP:0002937)2.82664162
39Congenital primary aphakia (HP:0007707)2.82456337
40Medial flaring of the eyebrow (HP:0010747)2.79297330
41Mixed hearing impairment (HP:0000410)2.78705063
42Congenital sensorineural hearing impairment (HP:0008527)2.76134263
43Abnormality of the antihelix (HP:0009738)2.75038962
44Hypoplastic labia majora (HP:0000059)2.71542986
45Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.70638821
46Renal duplication (HP:0000075)2.69063253
47Deep palmar crease (HP:0006191)2.68545482
48Growth hormone deficiency (HP:0000824)2.66785952
49Supernumerary bones of the axial skeleton (HP:0009144)2.64947046
50Abnormality of the 4th metacarpal (HP:0010012)2.64513837
51True hermaphroditism (HP:0010459)2.63595785
52Short 4th metacarpal (HP:0010044)2.57847613
53Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.57847613
54Cupped ear (HP:0000378)2.55322462
55Anosmia (HP:0000458)2.54031114
56Increased density of long bones (HP:0006392)2.51651614
57Nephrogenic diabetes insipidus (HP:0009806)2.51273333
58Abnormality of the labia majora (HP:0012881)2.49914887
59Tented upper lip vermilion (HP:0010804)2.49112824
60Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.46564692
61Vertebral arch anomaly (HP:0008438)2.46332855
62Specific learning disability (HP:0001328)2.43576368
63Partial duplication of thumb phalanx (HP:0009944)2.42905167
64Hypoventilation (HP:0002791)2.41509314
65Anal stenosis (HP:0002025)2.39974453
66Adactyly (HP:0009776)2.39680276
67Optic nerve hypoplasia (HP:0000609)2.37749312
68Abnormal sex determination (HP:0012244)2.37240025
69Sex reversal (HP:0012245)2.37240025
70Cerebellar dysplasia (HP:0007033)2.37215365
71Abnormality of the renal medulla (HP:0100957)2.36472962
72Skull defect (HP:0001362)2.35754086
73Cortical dysplasia (HP:0002539)2.32192753
74Overfolded helix (HP:0000396)2.31742449
75Partial duplication of the phalanx of hand (HP:0009999)2.30994546
76Supernumerary spleens (HP:0009799)2.28829072
77Abnormality of the labia (HP:0000058)2.24607962
78Preaxial foot polydactyly (HP:0001841)2.24344318
79Pancreatic fibrosis (HP:0100732)2.24005247
80Spina bifida occulta (HP:0003298)2.23040115
81Abnormally folded helix (HP:0008544)2.22374624
82Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.21339353
83Nephronophthisis (HP:0000090)2.20834443
84Renal hypoplasia (HP:0000089)2.19777984
85Hyperpituitarism (HP:0010514)2.19187181
86Absent radius (HP:0003974)2.16025800
87White forelock (HP:0002211)2.12710742
88Hip dysplasia (HP:0001385)2.12431775
89Broad toe (HP:0001837)2.12427826
90Thickened helices (HP:0000391)2.11698727
91Aplasia involving forearm bones (HP:0009822)2.10873199
92Absent forearm bone (HP:0003953)2.10873199
93Rib fusion (HP:0000902)2.08940139
94Split hand (HP:0001171)2.08794193
95Abnormality of the hip-girdle musculature (HP:0001445)2.08233653
96Abnormality of the musculature of the pelvis (HP:0001469)2.08233653
97Aplasia/Hypoplasia of the sternum (HP:0006714)2.07299840
98Shallow orbits (HP:0000586)2.06445476
99Aplasia cutis congenita (HP:0001057)2.04791622
100Neonatal short-limb short stature (HP:0008921)2.04142421
101Synostosis of carpal bones (HP:0005048)2.03706790
102Pancreatic cysts (HP:0001737)2.03671574
103Occipital encephalocele (HP:0002085)2.03009862
104Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.03001881
105Short 1st metacarpal (HP:0010034)2.03001881
106Bilateral microphthalmos (HP:0007633)2.01917767
107Bronchomalacia (HP:0002780)2.01791306
108Vaginal atresia (HP:0000148)2.01308145
109Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.00756525
110Poor coordination (HP:0002370)2.00593972
111Coarctation of aorta (HP:0001680)2.00238762
112Aplasia involving bones of the upper limbs (HP:0009823)1.99264909
113Aplasia of the phalanges of the hand (HP:0009802)1.99264909
114Aplasia involving bones of the extremities (HP:0009825)1.99264909
115Split foot (HP:0001839)1.98999278
116Abnormality of the odontoid process (HP:0003310)1.98764292
117Hallux valgus (HP:0001822)1.98551329
118Genital tract atresia (HP:0001827)1.96204852
119Cutaneous syndactyly (HP:0012725)1.96176855
120Absent septum pellucidum (HP:0001331)1.96126732
121Midline defect of the nose (HP:0004122)1.95027601
122Broad foot (HP:0001769)1.93886289
123Absent hand (HP:0004050)1.93669161
124Hyperglycinemia (HP:0002154)1.93474067
125Myelomeningocele (HP:0002475)1.93151016
126Bifid tongue (HP:0010297)1.93125118
127Deviation of the hallux (HP:0010051)1.92519290
128Cutaneous finger syndactyly (HP:0010554)1.92324650
129Abnormal respiratory motile cilium physiology (HP:0012261)1.90894179
130Limb-girdle muscle atrophy (HP:0003797)1.90674338
131Abnormality of midbrain morphology (HP:0002418)1.90581361
132Molar tooth sign on MRI (HP:0002419)1.90581361
133Short phalanx of the thumb (HP:0009660)1.90027452
134Papillary thyroid carcinoma (HP:0002895)1.89781542
135Abnormal biliary tract physiology (HP:0012439)1.89720919
136Bile duct proliferation (HP:0001408)1.89720919
137Laryngomalacia (HP:0001601)1.89499775
138Postaxial hand polydactyly (HP:0001162)1.89452021
139Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.88286163
140Vertebral fusion (HP:0002948)1.87695473
141Tracheomalacia (HP:0002779)1.86337435
142Rimmed vacuoles (HP:0003805)1.86214266
143Anencephaly (HP:0002323)1.85704195
144Decreased testicular size (HP:0008734)1.85643021
145Atelectasis (HP:0100750)1.84730507
146Short middle phalanx of the 5th finger (HP:0004220)1.84529102
147Drooling (HP:0002307)1.83045207
148Uterine leiomyosarcoma (HP:0002891)1.82950137
149Leiomyosarcoma (HP:0100243)1.82950137
150Type II lissencephaly (HP:0007260)1.82919335
151Urethral obstruction (HP:0000796)1.82771523
152Abnormality of the 1st metacarpal (HP:0010009)1.81691093
153Aplasia/Hypoplasia of the earlobes (HP:0009906)1.81571205
154Aplasia/Hypoplasia of the ulna (HP:0006495)1.80255248
155Pterygium (HP:0001059)1.80190843
156Preaxial hand polydactyly (HP:0001177)1.79973693
157Absent toe (HP:0010760)1.79909576
158Aganglionic megacolon (HP:0002251)1.79626933
159Abnormal number of incisors (HP:0011064)1.78533313
160Polyphagia (HP:0002591)1.76676632
161Postaxial foot polydactyly (HP:0001830)1.76544940
162Abnormal respiratory epithelium morphology (HP:0012253)1.76333525
163High anterior hairline (HP:0009890)1.76137259
164Esophageal varix (HP:0002040)1.75970627
165Mesomelia (HP:0003027)1.75804492
166Abdominal situs inversus (HP:0003363)1.71773669
167Abnormality of abdominal situs (HP:0011620)1.71773669
168Synostosis involving bones of the feet (HP:0009140)1.70908311
169Synostosis involving bones of the lower limbs (HP:0009138)1.70908311
170Hypoplasia of the ulna (HP:0003022)1.70852967
171Ridged nail (HP:0001807)1.69978215
172Bicornuate uterus (HP:0000813)1.67320476
173Abnormality of the intervertebral disk (HP:0005108)1.67132206

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB25.92716055
2BRSK14.54842268
3MELK3.63980397
4MAP4K23.60171885
5KSR13.22446077
6BUB13.12185323
7UHMK13.05902812
8CDK192.71192111
9MAP2K72.69820208
10WNK32.51428402
11MAP3K102.46950157
12CDC42BPA2.34361268
13MAP3K42.32718989
14MAPK112.15106571
15TGFBR12.09399834
16TRIB32.08296211
17ERBB21.87655119
18ICK1.85959825
19CDK121.58035827
20CSNK1G31.56829454
21ERBB31.54217254
22GSK3A1.52059698
23MKNK11.51972859
24AURKA1.47532059
25CSNK1G21.45850762
26CDK81.39407222
27CSNK1A1L1.38957682
28PTK61.35116041
29DYRK1B1.34894862
30SIK11.34628563
31CSNK1G11.33494777
32LATS11.30665633
33PLK31.26199121
34DYRK31.24303947
35IRAK11.23977343
36BRD41.21924911
37CDK91.21625123
38FGFR21.21172062
39STK241.21128075
40CASK1.18017253
41IRAK21.17909718
42CDK71.17030263
43DYRK1A1.14436441
44LATS21.14120340
45ADRBK21.13242902
46BCKDK1.11286683
47DMPK1.07327956
48MARK11.06600351
49TRIM281.05915030
50PAK31.01516318
51STK101.00119790
52DYRK20.99897485
53MKNK20.98928120
54BCR0.98062625
55NEK60.96259754
56PDGFRA0.94967888
57PAK40.94292186
58CDK30.92532711
59TYRO30.91840252
60PLK20.90350226
61LMTK20.89894892
62CAMK1G0.88056105
63CAMK1D0.87463514
64PAK60.84298264
65PASK0.82251458
66MAPKAPK20.80550014
67FER0.80374239
68SIK30.79453756
69PINK10.78991794
70PIK3CA0.78690355
71FGFR30.77510257
72TIE10.76649193
73PRKCG0.75782628
74PNCK0.75185020
75RPS6KA10.74699605
76MARK20.74153084
77RPS6KA40.73776971
78PBK0.73604954
79ROCK20.73522941
80TESK20.72752502
81NEK20.72720228
82SIK20.72589270
83SGK2230.72308599
84SGK4940.72308599
85DDR20.71573728
86FGFR10.71481743
87EPHA30.71213073
88MARK30.70105593
89MAPK150.69109788
90CDC70.68585609
91STK38L0.68077555
92PLK10.67154987
93YES10.66740308
94FGFR40.66356640
95PKN20.64045056
96EPHB10.62745894
97ERBB40.61755272
98NTRK20.61303653
99BRSK20.60185534
100LRRK20.60121692
101CDK60.60085732
102MAPK70.59821870
103GRK10.58096399
104SRPK10.57643718
105AURKB0.57308531
106PRKAA10.56886117
107MAP3K80.56563859
108MAP2K40.54869931
109CHEK10.53852283
110PAK20.52995064
111GRK70.52495999
112ILK0.51046658
113BMPR1B0.50974862
114TSSK60.47765606
115CAMK40.47726866
116CDK50.47553036
117MTOR0.47487904
118NEK10.47171959
119EEF2K0.47047367
120EPHA40.44315938
121CSNK1A10.43792922
122CSK0.42754474
123AKT20.42468462
124PRKCZ0.41157151
125CDK40.41130690
126CAMK2G0.39118632
127CHUK0.38495684
128KDR0.38020417
129CDK140.37601297
130CSNK2A10.37071960
131MAPK130.36918866
132PKN10.36782442
133CSNK1E0.36644997
134CAMK10.36566546
135PHKG10.36524402
136PHKG20.36524402
137CAMK2B0.36312285
138CDK11A0.36142007
139MUSK0.36008175
140RPS6KA60.35495473
141CDK10.34815321
142RPS6KA50.34678119
143CDK180.34558708
144MAPK90.32711631
145TTK0.32164440
146RPS6KC10.31931283
147RPS6KL10.31931283
148RIPK10.31873673
149CDK150.31646447
150PTK20.31609174
151MAP3K70.31508919
152MATK0.30180773
153PRKCE0.29432722
154LIMK10.29035257
155CSNK1D0.28915230
156SGK20.28417734
157AKT10.28036499
158STK110.27647966

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.86179248
2* Notch signaling pathway_Homo sapiens_hsa043304.35232742
3Hedgehog signaling pathway_Homo sapiens_hsa043403.64038079
4Axon guidance_Homo sapiens_hsa043603.04442553
5Hippo signaling pathway_Homo sapiens_hsa043902.90898632
6Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.75055319
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.66211447
8MicroRNAs in cancer_Homo sapiens_hsa052062.44887340
9Protein export_Homo sapiens_hsa030602.25871264
10Spliceosome_Homo sapiens_hsa030402.24827927
11Lysine degradation_Homo sapiens_hsa003102.18621262
12Cell cycle_Homo sapiens_hsa041102.18127712
13Wnt signaling pathway_Homo sapiens_hsa043102.08151108
14Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.81447643
15Melanogenesis_Homo sapiens_hsa049161.80600793
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.79278197
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78058641
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.75382600
19Nitrogen metabolism_Homo sapiens_hsa009101.74715149
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66706109
21Basal transcription factors_Homo sapiens_hsa030221.66057186
22Bladder cancer_Homo sapiens_hsa052191.57326647
23Adherens junction_Homo sapiens_hsa045201.57291775
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.57099389
25TGF-beta signaling pathway_Homo sapiens_hsa043501.55643468
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.53732372
27Fat digestion and absorption_Homo sapiens_hsa049751.48856199
28Nicotine addiction_Homo sapiens_hsa050331.48502587
29GABAergic synapse_Homo sapiens_hsa047271.47937194
30Dorso-ventral axis formation_Homo sapiens_hsa043201.40937336
31Tight junction_Homo sapiens_hsa045301.37019815
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35788140
33Renal cell carcinoma_Homo sapiens_hsa052111.35098766
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.28436066
35Proteoglycans in cancer_Homo sapiens_hsa052051.27982928
36Prion diseases_Homo sapiens_hsa050201.27978982
37Parkinsons disease_Homo sapiens_hsa050121.25086189
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23943683
39Collecting duct acid secretion_Homo sapiens_hsa049661.22922145
40Pathways in cancer_Homo sapiens_hsa052001.22843344
41Propanoate metabolism_Homo sapiens_hsa006401.22332705
42Small cell lung cancer_Homo sapiens_hsa052221.21775369
43beta-Alanine metabolism_Homo sapiens_hsa004101.21746997
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18501805
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.17478059
46HTLV-I infection_Homo sapiens_hsa051661.17352022
47Oxidative phosphorylation_Homo sapiens_hsa001901.16640918
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12277336
49Colorectal cancer_Homo sapiens_hsa052101.12199063
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11704534
51Sulfur relay system_Homo sapiens_hsa041221.11130259
52Cardiac muscle contraction_Homo sapiens_hsa042601.07489058
53Ether lipid metabolism_Homo sapiens_hsa005651.06246729
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05220383
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03888542
56Linoleic acid metabolism_Homo sapiens_hsa005911.00011108
57Viral myocarditis_Homo sapiens_hsa054160.99372833
58Cholinergic synapse_Homo sapiens_hsa047250.98309845
59Huntingtons disease_Homo sapiens_hsa050160.97409159
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95245690
61mRNA surveillance pathway_Homo sapiens_hsa030150.94341465
62Butanoate metabolism_Homo sapiens_hsa006500.92527288
63Tryptophan metabolism_Homo sapiens_hsa003800.92039170
64ECM-receptor interaction_Homo sapiens_hsa045120.90860960
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.90475639
66Chronic myeloid leukemia_Homo sapiens_hsa052200.89975250
67Oocyte meiosis_Homo sapiens_hsa041140.87237828
68Glutamatergic synapse_Homo sapiens_hsa047240.85080556
69Cocaine addiction_Homo sapiens_hsa050300.84927096
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83519950
71Pancreatic cancer_Homo sapiens_hsa052120.83413725
72Focal adhesion_Homo sapiens_hsa045100.82614946
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81987901
74Gap junction_Homo sapiens_hsa045400.81819094
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.80380816
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79208363
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78127985
78Circadian entrainment_Homo sapiens_hsa047130.74093328
79Arginine biosynthesis_Homo sapiens_hsa002200.71905842
80Regulation of autophagy_Homo sapiens_hsa041400.71245584
81Phototransduction_Homo sapiens_hsa047440.70069172
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68491282
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68015879
84Morphine addiction_Homo sapiens_hsa050320.67732500
85Steroid biosynthesis_Homo sapiens_hsa001000.67638754
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67451948
87Glycerolipid metabolism_Homo sapiens_hsa005610.67393661
88Dilated cardiomyopathy_Homo sapiens_hsa054140.66572893
89Peroxisome_Homo sapiens_hsa041460.66013453
90Bile secretion_Homo sapiens_hsa049760.65857123
91Arginine and proline metabolism_Homo sapiens_hsa003300.65159721
92RNA transport_Homo sapiens_hsa030130.64927063
93Rap1 signaling pathway_Homo sapiens_hsa040150.64499555
94Taste transduction_Homo sapiens_hsa047420.64310082
95Salmonella infection_Homo sapiens_hsa051320.62975125
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61548999
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60936458
98Fatty acid degradation_Homo sapiens_hsa000710.60831025
99Fatty acid metabolism_Homo sapiens_hsa012120.60134646
100RNA degradation_Homo sapiens_hsa030180.60065723
101Hepatitis B_Homo sapiens_hsa051610.59376685
102Circadian rhythm_Homo sapiens_hsa047100.57754530
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57504852
104Estrogen signaling pathway_Homo sapiens_hsa049150.56361488
105Glioma_Homo sapiens_hsa052140.56238379
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55019748
107Endometrial cancer_Homo sapiens_hsa052130.54684191
108Ribosome_Homo sapiens_hsa030100.53669571
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53051022
110cAMP signaling pathway_Homo sapiens_hsa040240.52428396
111Vibrio cholerae infection_Homo sapiens_hsa051100.52338736
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51738890
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50938202
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47581568
115Fanconi anemia pathway_Homo sapiens_hsa034600.44649330
116Alzheimers disease_Homo sapiens_hsa050100.43090522
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42833122
118Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42518789
119PPAR signaling pathway_Homo sapiens_hsa033200.42248685
120Fatty acid elongation_Homo sapiens_hsa000620.42138930
121Melanoma_Homo sapiens_hsa052180.41802105
122MAPK signaling pathway_Homo sapiens_hsa040100.41527545
123Prostate cancer_Homo sapiens_hsa052150.41301902
124Histidine metabolism_Homo sapiens_hsa003400.41103820
125Protein digestion and absorption_Homo sapiens_hsa049740.39881369
126Complement and coagulation cascades_Homo sapiens_hsa046100.39248361
127Serotonergic synapse_Homo sapiens_hsa047260.39129032
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38162243
129Insulin secretion_Homo sapiens_hsa049110.37367587
130p53 signaling pathway_Homo sapiens_hsa041150.36360721
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36303858
132Metabolic pathways_Homo sapiens_hsa011000.35527034
133Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35229336
134ErbB signaling pathway_Homo sapiens_hsa040120.34903564
135AMPK signaling pathway_Homo sapiens_hsa041520.33825712
136VEGF signaling pathway_Homo sapiens_hsa043700.33473058
137FoxO signaling pathway_Homo sapiens_hsa040680.33104087
138Ovarian steroidogenesis_Homo sapiens_hsa049130.31262050
139Non-small cell lung cancer_Homo sapiens_hsa052230.31199018
140Biosynthesis of amino acids_Homo sapiens_hsa012300.31021993
141Leukocyte transendothelial migration_Homo sapiens_hsa046700.29832907
142Insulin resistance_Homo sapiens_hsa049310.29518001
143Viral carcinogenesis_Homo sapiens_hsa052030.28478497
144Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28476809
145Selenocompound metabolism_Homo sapiens_hsa004500.28447761
146Dopaminergic synapse_Homo sapiens_hsa047280.27396774
147Retinol metabolism_Homo sapiens_hsa008300.27120356
148Glucagon signaling pathway_Homo sapiens_hsa049220.26864759
149Alcoholism_Homo sapiens_hsa050340.24171811
150Renin secretion_Homo sapiens_hsa049240.22073969
151Amoebiasis_Homo sapiens_hsa051460.20008158
152Carbon metabolism_Homo sapiens_hsa012000.19689847

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