DLL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.60985593
2behavioral response to nicotine (GO:0035095)7.05061682
3* paraxial mesoderm development (GO:0048339)6.20731935
4regulation of T cell tolerance induction (GO:0002664)5.83483849
5nucleobase catabolic process (GO:0046113)5.62585667
6substrate-independent telencephalic tangential interneuron migration (GO:0021843)5.53137294
7substrate-independent telencephalic tangential migration (GO:0021826)5.53137294
8regulation of exit from mitosis (GO:0007096)5.27226751
9negative regulation of oligodendrocyte differentiation (GO:0048715)4.71138217
10neuron fate determination (GO:0048664)4.67806357
11negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.67435640
12neuronal stem cell maintenance (GO:0097150)4.55152297
13postsynaptic membrane organization (GO:0001941)4.53694570
14positive regulation of tolerance induction (GO:0002645)4.44456010
15glial cell proliferation (GO:0014009)4.41676818
16locomotory exploration behavior (GO:0035641)4.36616909
17presynaptic membrane organization (GO:0097090)4.34705868
18positive regulation of Notch signaling pathway (GO:0045747)4.28079956
19cell migration in hindbrain (GO:0021535)4.26190370
20signal transduction involved in regulation of gene expression (GO:0023019)4.22967887
21mechanosensory behavior (GO:0007638)4.15158823
22midbrain development (GO:0030901)4.12664863
23regulation of alternative mRNA splicing, via spliceosome (GO:0000381)4.12440887
24establishment of mitochondrion localization (GO:0051654)4.12399704
25regulation of tolerance induction (GO:0002643)4.08550821
26positive regulation of cell size (GO:0045793)4.05415603
27peptidyl-arginine omega-N-methylation (GO:0035247)4.04276074
28negative regulation of cell cycle arrest (GO:0071157)4.00527364
29G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.96288603
30regulation of mesoderm development (GO:2000380)3.95767284
31pattern specification involved in kidney development (GO:0061004)3.94068019
32presynaptic membrane assembly (GO:0097105)3.91141457
33notochord development (GO:0030903)3.88863828
34cell migration involved in heart development (GO:0060973)3.88643127
35olfactory bulb development (GO:0021772)3.86049168
36regulation of growth hormone secretion (GO:0060123)3.85949871
37positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.85058101
38positive regulation of cell cycle G2/M phase transition (GO:1902751)3.85058101
39auditory behavior (GO:0031223)3.82053940
40negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.81998509
41neuron recognition (GO:0008038)3.81840263
42ganglion development (GO:0061548)3.80062173
43somite rostral/caudal axis specification (GO:0032525)3.78516888
44neuron cell-cell adhesion (GO:0007158)3.77560911
45calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.72977161
46positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.71497506
47NLS-bearing protein import into nucleus (GO:0006607)3.71286119
48positive regulation of growth hormone secretion (GO:0060124)3.70574747
49neuromuscular synaptic transmission (GO:0007274)3.68619111
50synapse assembly (GO:0007416)3.67597229
51synaptic transmission, cholinergic (GO:0007271)3.65941930
52protein localization to synapse (GO:0035418)3.61747556
53neuronal ion channel clustering (GO:0045161)3.61122516
54regulation of synapse structural plasticity (GO:0051823)3.58272308
55mitochondrion transport along microtubule (GO:0047497)3.57999242
56establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.57999242
57peristalsis (GO:0030432)3.57613559
58DNA deamination (GO:0045006)3.56671753
59exploration behavior (GO:0035640)3.49901996
60axonal fasciculation (GO:0007413)3.46066576
61forebrain neuron differentiation (GO:0021879)3.45957525
62primitive streak formation (GO:0090009)3.45598756
63peptidyl-arginine methylation (GO:0018216)3.44313743
64peptidyl-arginine N-methylation (GO:0035246)3.44313743
65left/right axis specification (GO:0070986)3.43623283
66central nervous system myelination (GO:0022010)3.41999613
67axon ensheathment in central nervous system (GO:0032291)3.41999613
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.39406637
69regulation of chromatin binding (GO:0035561)3.36765874
70cerebral cortex neuron differentiation (GO:0021895)3.36328216
71positive regulation by host of viral transcription (GO:0043923)3.31804079
72regulation of NFAT protein import into nucleus (GO:0051532)3.30756878
73epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.29774129
74DNA unwinding involved in DNA replication (GO:0006268)3.29243028
75segment specification (GO:0007379)3.28581493
76transmission of nerve impulse (GO:0019226)3.27262397
77regulation of mRNA splicing, via spliceosome (GO:0048024)3.26134200
78cell differentiation in spinal cord (GO:0021515)3.25481184
79mating behavior (GO:0007617)3.23683920
80cerebellum development (GO:0021549)3.23472379
81nucleosome disassembly (GO:0006337)3.21076502
82protein-DNA complex disassembly (GO:0032986)3.21076502
83neuron fate specification (GO:0048665)3.20016628
84negative regulation of axon guidance (GO:1902668)3.18897366
85hippocampus development (GO:0021766)3.18866841
86adult walking behavior (GO:0007628)3.18346084
87central nervous system projection neuron axonogenesis (GO:0021952)3.17251704
88Notch signaling involved in heart development (GO:0061314)3.16644453
89sympathetic nervous system development (GO:0048485)3.13942589
90positive regulation of gastrulation (GO:2000543)3.13832642
91histone arginine methylation (GO:0034969)3.11863868
92neuron fate commitment (GO:0048663)3.11177268
93L-serine transport (GO:0015825)3.09233674
94astrocyte differentiation (GO:0048708)3.08794342
95establishment of planar polarity (GO:0001736)3.08793413
96establishment of tissue polarity (GO:0007164)3.08793413
97regulation of oligodendrocyte differentiation (GO:0048713)3.07800030
98positive regulation of oligodendrocyte differentiation (GO:0048714)3.07411876
99removal of superoxide radicals (GO:0019430)3.07380629
100cellular response to superoxide (GO:0071451)3.07380629
101cellular response to oxygen radical (GO:0071450)3.07380629
102positive regulation of mitochondrial fission (GO:0090141)3.06382829
103radial glial cell differentiation (GO:0060019)3.05051255
104cranial nerve development (GO:0021545)3.04881460
105positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.02180569
106mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.02180569
107cochlea morphogenesis (GO:0090103)3.01830512
108nephron tubule development (GO:0072080)3.01098323
109limb bud formation (GO:0060174)2.99827104
110pre-miRNA processing (GO:0031054)2.98317308
111negative regulation of neurotransmitter secretion (GO:0046929)2.95589589
112nodal signaling pathway (GO:0038092)2.95283949
113planar cell polarity pathway involved in neural tube closure (GO:0090179)2.93631517
114regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.92783597
115negative regulation of cytosolic calcium ion concentration (GO:0051481)2.91688148
116neurofilament cytoskeleton organization (GO:0060052)2.91504063
117retinal ganglion cell axon guidance (GO:0031290)2.91314701
118neuron maturation (GO:0042551)2.90409449
119negative regulation of axon extension involved in axon guidance (GO:0048843)2.88801506
120myeloid cell homeostasis (GO:0002262)2.88735928
121mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.88650336
122positive regulation of protein homodimerization activity (GO:0090073)2.88513502
123protein-cofactor linkage (GO:0018065)2.86027716
124neuron migration (GO:0001764)2.84831907
125Notch receptor processing (GO:0007220)2.83883347
126dendrite morphogenesis (GO:0048813)2.83551346
127nonmotile primary cilium assembly (GO:0035058)2.83382027
128neuron projection extension involved in neuron projection guidance (GO:1902284)2.82067423
129axon extension involved in axon guidance (GO:0048846)2.82067423
130nephron tubule morphogenesis (GO:0072078)2.81635680
131nephron epithelium morphogenesis (GO:0072088)2.81635680
132ovulation cycle (GO:0042698)2.80305657
133response to BMP (GO:0071772)2.79609209
134cellular response to BMP stimulus (GO:0071773)2.79609209
135positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.79488886
136post-anal tail morphogenesis (GO:0036342)2.78873698
137cell migration involved in gastrulation (GO:0042074)2.78805814
138response to auditory stimulus (GO:0010996)2.78531701
139synaptic transmission, dopaminergic (GO:0001963)2.78452443
140spinal cord association neuron differentiation (GO:0021527)2.78287243
141inner ear morphogenesis (GO:0042472)2.77138768
142photoreceptor cell differentiation (GO:0046530)2.73702255
143eye photoreceptor cell differentiation (GO:0001754)2.73702255
144regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.73044539
145enteric nervous system development (GO:0048484)2.73004290
146regulation of development, heterochronic (GO:0040034)2.71186609
147dendritic spine morphogenesis (GO:0060997)2.69902187
148* mesoderm development (GO:0007498)2.69607142
149cardiac ventricle formation (GO:0003211)2.69115810
150embryonic hindlimb morphogenesis (GO:0035116)2.69018985
151regulation of RNA splicing (GO:0043484)2.67855747
152positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.66378847
153ear development (GO:0043583)2.66246675
154negative regulation of catecholamine secretion (GO:0033604)2.65381987
155synapse organization (GO:0050808)2.65253939
156negative regulation of epidermal cell differentiation (GO:0045605)2.63698080
157central nervous system neuron development (GO:0021954)2.63508455
158negative regulation of glial cell differentiation (GO:0045686)2.63377270
159negative regulation of epidermis development (GO:0045683)2.63274686
160spinal cord development (GO:0021510)2.62784270
161regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.62567887
162otic vesicle formation (GO:0030916)2.62348536
163neurotransmitter-gated ion channel clustering (GO:0072578)2.61238651
164central nervous system neuron axonogenesis (GO:0021955)2.60999694
165behavioral response to ethanol (GO:0048149)2.60519376
166negative regulation of microtubule polymerization (GO:0031115)2.60514078
167regulation of timing of cell differentiation (GO:0048505)2.60407087
168serine transport (GO:0032329)2.59796042
169thalamus development (GO:0021794)2.58982711
170cerebral cortex radially oriented cell migration (GO:0021799)2.58765986
171synaptic vesicle maturation (GO:0016188)2.58507717
172negative regulation of interleukin-10 production (GO:0032693)2.58448654
173negative regulation of astrocyte differentiation (GO:0048712)2.58086141
174ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.57737163
175regulation of somitogenesis (GO:0014807)2.57159151
176renal tubule development (GO:0061326)2.57086963
177ventricular trabecula myocardium morphogenesis (GO:0003222)2.55266909
178ionotropic glutamate receptor signaling pathway (GO:0035235)2.55113082
179central nervous system neuron differentiation (GO:0021953)2.54946750
180regulation of cilium movement (GO:0003352)2.54143036
181regulation of neurotransmitter uptake (GO:0051580)2.52765308
182microtubule severing (GO:0051013)2.52103051
183regulation of synaptic transmission, glutamatergic (GO:0051966)2.50127491
184negative regulation of axonogenesis (GO:0050771)2.49502704
185dopaminergic neuron differentiation (GO:0071542)10.2749267

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_19390658_ChIP-ChIP_HaCaT_Human4.94134994
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.84768115
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.66488137
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.41510461
5EZH2_22144423_ChIP-Seq_EOC_Human3.25856051
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.24353437
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.08568647
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.64201381
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.64142705
10PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.60858880
11POU5F1_16153702_ChIP-ChIP_HESCs_Human2.60622224
12* OLIG2_26023283_ChIP-Seq_AINV15_Mouse2.52705816
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.50958458
14REST_21632747_ChIP-Seq_MESCs_Mouse2.40021187
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.31871414
16SOX2_16153702_ChIP-ChIP_HESCs_Human2.30540810
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.24521931
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.15589856
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.14832181
20E2F7_22180533_ChIP-Seq_HELA_Human2.14248909
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.14170557
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.13790482
23SOX2_18555785_ChIP-Seq_MESCs_Mouse2.07851501
24* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.04347256
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.99574208
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95946337
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.93687277
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88420044
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88420044
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.87846443
31XRN2_22483619_ChIP-Seq_HELA_Human1.84148078
32KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.83327783
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.83201432
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.82629278
35TP53_20018659_ChIP-ChIP_R1E_Mouse1.79494656
36* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.75777339
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.74047735
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69611690
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.64398993
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.63286591
41ZNF274_21170338_ChIP-Seq_K562_Hela1.61149992
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.57987902
43CIITA_25753668_ChIP-Seq_RAJI_Human1.55904723
44* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55794060
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52055811
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.51328908
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.51328908
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.51328908
49SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.48964036
50MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48674648
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48672439
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48055920
53RNF2_27304074_Chip-Seq_NSC_Mouse1.46768726
54TTF2_22483619_ChIP-Seq_HELA_Human1.46348574
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45856508
56* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45486695
57WDR5_24793694_ChIP-Seq_LNCAP_Human1.43962418
58* RING1B_27294783_Chip-Seq_ESCs_Mouse1.40185956
59IGF1R_20145208_ChIP-Seq_DFB_Human1.39693302
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39278698
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38231362
62SOX3_22085726_ChIP-Seq_NPCs_Mouse1.37229106
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36211995
64SOX2_18692474_ChIP-Seq_MESCs_Mouse1.34581368
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.34184341
66SOX2_18692474_ChIP-Seq_MEFs_Mouse1.32899088
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32734702
68ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.31610172
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30187316
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.29949716
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.29626190
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29047426
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28869878
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28668770
75GABP_17652178_ChIP-ChIP_JURKAT_Human1.28533939
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.28189624
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27823255
78CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.27407302
79IRF1_19129219_ChIP-ChIP_H3396_Human1.26091349
80KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23974648
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23593723
82RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23277842
83TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.23117786
84* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22748435
85TCF3_18692474_ChIP-Seq_MESCs_Mouse1.20774146
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19136515
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18731237
88MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17641876
89SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15489574
90VDR_22108803_ChIP-Seq_LS180_Human1.15359023
91RARB_27405468_Chip-Seq_BRAIN_Mouse1.15202829
92MYC_19079543_ChIP-ChIP_MESCs_Mouse1.13026770
93ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12530137
94TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12030471
95YY1_22570637_ChIP-Seq_MALME-3M_Human1.10909348
96GATA1_26923725_Chip-Seq_HPCs_Mouse1.10357984
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09379723
98CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09238057
99GBX2_23144817_ChIP-Seq_PC3_Human1.08991763
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08469839
101YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08334121
102ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07335709
103NANOG_16153702_ChIP-ChIP_HESCs_Human1.06907037
104POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.04278612
105FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03940210
106SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03723054
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02105448
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01529836
109LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01491695
110NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.01483259
111CTCF_27219007_Chip-Seq_Bcells_Human1.01248367
112* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01052701
113* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.00943030
114E2F4_17652178_ChIP-ChIP_JURKAT_Human1.00139827
115TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.98560088
116DROSHA_22980978_ChIP-Seq_HELA_Human0.98523178
117RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98447351
118EST1_17652178_ChIP-ChIP_JURKAT_Human0.98267391
119MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97856162
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96642738
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96642738
122SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96267672
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95268967
124PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92672047
125ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91174764
126NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.83443136
127* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82464914
128SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82309484
129ZFP57_27257070_Chip-Seq_ESCs_Mouse0.81110887
130NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.79714617
131RUNX1_26923725_Chip-Seq_HPCs_Mouse0.79617763
132MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.78575446
133KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.78063693
134DNAJC2_21179169_ChIP-ChIP_NT2_Human0.77825837
135TAF15_26573619_Chip-Seq_HEK293_Human0.77315934
136TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.76878540
137SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76822020
138POU5F1_16518401_ChIP-PET_MESCs_Mouse0.76805983
139SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.76295086
140ISL1_27105846_Chip-Seq_CPCs_Mouse0.74594787
141KDM2B_26808549_Chip-Seq_K562_Human0.74147404
142MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.70261491
143GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.69595451
144CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69415550

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.50672599
2MP0010030_abnormal_orbit_morphology4.11622055
3MP0003315_abnormal_perineum_morphology3.66589921
4MP0002822_catalepsy3.61461908
5MP0008789_abnormal_olfactory_epithelium3.33989397
6MP0003890_abnormal_embryonic-extraembry3.20057960
7MP0003787_abnormal_imprinting2.84559055
8MP0003183_abnormal_peptide_metabolism2.81503263
9MP0005499_abnormal_olfactory_system2.68644288
10MP0005394_taste/olfaction_phenotype2.68644288
11MP0001346_abnormal_lacrimal_gland2.53625099
12MP0008995_early_reproductive_senescence2.53271717
13MP0003119_abnormal_digestive_system2.49466400
14MP0000778_abnormal_nervous_system2.37806494
15MP0005187_abnormal_penis_morphology2.30702677
16* MP0002653_abnormal_ependyma_morphology2.22979534
17MP0000049_abnormal_middle_ear2.22683442
18MP0004133_heterotaxia2.20616671
19MP0001529_abnormal_vocalization2.18070936
20MP0003938_abnormal_ear_development2.15546662
21MP0006276_abnormal_autonomic_nervous2.14232476
22MP0004270_analgesia2.10957748
23MP0001188_hyperpigmentation2.05141796
24MP0003635_abnormal_synaptic_transmissio1.97099851
25MP0003122_maternal_imprinting1.88098933
26MP0003937_abnormal_limbs/digits/tail_de1.84036853
27MP0002272_abnormal_nervous_system1.83906886
28MP0002234_abnormal_pharynx_morphology1.83234679
29MP0001486_abnormal_startle_reflex1.77191025
30MP0005171_absent_coat_pigmentation1.74510676
31MP0002938_white_spotting1.74427216
32MP0003123_paternal_imprinting1.71801928
33MP0004859_abnormal_synaptic_plasticity1.71736552
34MP0008932_abnormal_embryonic_tissue1.70232557
35MP0002063_abnormal_learning/memory/cond1.67357690
36* MP0003861_abnormal_nervous_system1.66729494
37MP0004142_abnormal_muscle_tone1.65247480
38MP0001984_abnormal_olfaction1.64862073
39MP0001849_ear_inflammation1.64420125
40MP0002734_abnormal_mechanical_nocicepti1.63736332
41MP0006292_abnormal_olfactory_placode1.62573254
42MP0002638_abnormal_pupillary_reflex1.62169611
43MP0002282_abnormal_trachea_morphology1.61822903
44MP0009745_abnormal_behavioral_response1.60369805
45MP0008260_abnormal_autophagy1.60117502
46MP0002102_abnormal_ear_morphology1.59240241
47MP0010386_abnormal_urinary_bladder1.57717827
48MP0001905_abnormal_dopamine_level1.55683980
49MP0003121_genomic_imprinting1.55041559
50* MP0002751_abnormal_autonomic_nervous1.54729228
51MP0002909_abnormal_adrenal_gland1.53677449
52MP0002572_abnormal_emotion/affect_behav1.51835953
53MP0004885_abnormal_endolymph1.50315043
54MP0002064_seizures1.50037543
55MP0002184_abnormal_innervation1.49228397
56MP0005253_abnormal_eye_physiology1.47747711
57MP0005645_abnormal_hypothalamus_physiol1.46545528
58MP0000026_abnormal_inner_ear1.43563234
59MP0002177_abnormal_outer_ear1.42836502
60MP0000631_abnormal_neuroendocrine_gland1.40773186
61MP0000537_abnormal_urethra_morphology1.37765352
62MP0002736_abnormal_nociception_after1.37154116
63MP0003942_abnormal_urinary_system1.36023442
64MP0002249_abnormal_larynx_morphology1.33222916
65MP0002067_abnormal_sensory_capabilities1.32445415
66MP0002733_abnormal_thermal_nociception1.31113385
67MP0008007_abnormal_cellular_replicative1.30202087
68MP0003935_abnormal_craniofacial_develop1.27777764
69MP0005167_abnormal_blood-brain_barrier1.27378699
70MP0009697_abnormal_copulation1.26343601
71MP0001968_abnormal_touch/_nociception1.25556716
72* MP0002116_abnormal_craniofacial_bone1.25532603
73MP0002735_abnormal_chemical_nociception1.25259625
74MP0001970_abnormal_pain_threshold1.25227667
75MP0003172_abnormal_lysosome_physiology1.21951591
76MP0003137_abnormal_impulse_conducting1.21211124
77* MP0002752_abnormal_somatic_nervous1.20473508
78MP0003077_abnormal_cell_cycle1.20366416
79MP0001286_abnormal_eye_development1.18400900
80MP0001730_embryonic_growth_arrest1.16056432
81MP0001502_abnormal_circadian_rhythm1.14155457
82MP0008961_abnormal_basal_metabolism1.13828013
83MP0003115_abnormal_respiratory_system1.13658052
84MP0000538_abnormal_urinary_bladder1.13335810
85MP0003693_abnormal_embryo_hatching1.12494830
86* MP0002152_abnormal_brain_morphology1.11535700
87MP0002233_abnormal_nose_morphology1.08154921
88MP0005646_abnormal_pituitary_gland1.07217663
89MP0005197_abnormal_uvea_morphology1.06422623
90* MP0002085_abnormal_embryonic_tissue1.06100657
91MP0002160_abnormal_reproductive_system1.05973367
92MP0009250_abnormal_appendicular_skeleto1.04179719
93MP0003632_abnormal_nervous_system1.04019924
94MP0002069_abnormal_eating/drinking_beha1.03970900
95MP0005248_abnormal_Harderian_gland0.99689041
96MP0005386_behavior/neurological_phenoty0.98667949
97MP0004924_abnormal_behavior0.98667949
98* MP0002111_abnormal_tail_morphology0.98161718
99MP0000350_abnormal_cell_proliferation0.97056508
100MP0001299_abnormal_eye_distance/0.96205392
101MP0001485_abnormal_pinna_reflex0.95581662
102MP0009046_muscle_twitch0.94942863
103MP0003385_abnormal_body_wall0.94293564
104* MP0002066_abnormal_motor_capabilities/c0.94153063
105MP0005379_endocrine/exocrine_gland_phen0.93763873
106MP0010094_abnormal_chromosome_stability0.92107774
107MP0006072_abnormal_retinal_apoptosis0.91764004
108MP0003755_abnormal_palate_morphology0.91492523
109MP0000569_abnormal_digit_pigmentation0.91179259
110MP0002092_abnormal_eye_morphology0.90375864
111MP0005551_abnormal_eye_electrophysiolog0.89484700
112MP0002928_abnormal_bile_duct0.89360554
113MP0002163_abnormal_gland_morphology0.87995742
114MP0005423_abnormal_somatic_nervous0.87282497
115MP0004742_abnormal_vestibular_system0.86852087
116MP0004811_abnormal_neuron_physiology0.86524556
117* MP0002932_abnormal_joint_morphology0.85769839
118MP0002882_abnormal_neuron_morphology0.85360130
119MP0002081_perinatal_lethality0.85175878
120* MP0002084_abnormal_developmental_patter0.84519364
121MP0001270_distended_abdomen0.84116999
122MP0000647_abnormal_sebaceous_gland0.82631941
123MP0002095_abnormal_skin_pigmentation0.82615879
124MP0003136_yellow_coat_color0.82012541
125MP0001293_anophthalmia0.81108695
126MP0003011_delayed_dark_adaptation0.80826218
127MP0005195_abnormal_posterior_eye0.80607403
128MP0000955_abnormal_spinal_cord0.80018286
129MP0005391_vision/eye_phenotype0.79740798
130MP0001963_abnormal_hearing_physiology0.79621123
131MP0003880_abnormal_central_pattern0.79307433
132MP0003329_amyloid_beta_deposits0.77801594
133MP0003111_abnormal_nucleus_morphology0.77331646
134MP0001727_abnormal_embryo_implantation0.77317099
135MP0009053_abnormal_anal_canal0.77118257
136* MP0002557_abnormal_social/conspecific_i0.77061000
137MP0000534_abnormal_ureter_morphology0.74408344
138MP0000432_abnormal_head_morphology0.73589110
139MP0003091_abnormal_cell_migration0.73491252
140MP0009379_abnormal_foot_pigmentation0.73255167
141MP0005380_embryogenesis_phenotype0.72993347
142MP0001672_abnormal_embryogenesis/_devel0.72993347
143MP0004085_abnormal_heartbeat0.72372295
144MP0000462_abnormal_digestive_system0.71713225
145MP0001440_abnormal_grooming_behavior0.71596236
146MP0001943_abnormal_respiration0.71365180
147MP0004883_abnormal_blood_vessel0.70790835
148MP0003786_premature_aging0.69716648
149MP0003634_abnormal_glial_cell0.69511022
150MP0001697_abnormal_embryo_size0.68449327
151MP0004957_abnormal_blastocyst_morpholog0.67980469
152MP0001119_abnormal_female_reproductive0.66742355

Predicted human phenotypes

RankGene SetZ-score
1Anterior segment dysgenesis (HP:0007700)5.35534220
2Wrist flexion contracture (HP:0001239)5.23912327
3Degeneration of anterior horn cells (HP:0002398)4.91102531
4Abnormality of the anterior horn cell (HP:0006802)4.91102531
5Concave nail (HP:0001598)4.83560305
6Myokymia (HP:0002411)4.61323120
7Down-sloping shoulders (HP:0200021)4.06764987
8Intestinal atresia (HP:0011100)3.85775607
9Aplasia/Hypoplasia of the brainstem (HP:0007362)3.55116968
10Hypoplasia of the brainstem (HP:0002365)3.55116968
11Oligodactyly (hands) (HP:0001180)3.49940262
12Gait imbalance (HP:0002141)3.37395042
13High anterior hairline (HP:0009890)3.28340670
14Exotropia (HP:0000577)3.25494635
15Amblyopia (HP:0000646)3.24709569
16Oligodactyly (HP:0012165)3.20588910
17Aplasia/Hypoplasia of the patella (HP:0006498)3.14926108
18Cortical dysplasia (HP:0002539)3.07180296
19Abnormal sex determination (HP:0012244)3.03779850
20Sex reversal (HP:0012245)3.03779850
21Medial flaring of the eyebrow (HP:0010747)3.01950942
22Congenital primary aphakia (HP:0007707)3.01390738
23Hepatoblastoma (HP:0002884)2.99852239
24Stenosis of the external auditory canal (HP:0000402)2.91601538
25Polyphagia (HP:0002591)2.88794750
26Nephrogenic diabetes insipidus (HP:0009806)2.85692810
27External ophthalmoplegia (HP:0000544)2.77214009
28Aplasia of the musculature (HP:0100854)2.70243232
29Peripheral hypomyelination (HP:0007182)2.70128074
30Chorioretinal atrophy (HP:0000533)2.69276596
31Aplasia/Hypoplasia involving the musculature (HP:0001460)2.67823364
32Morphological abnormality of the inner ear (HP:0011390)2.61917250
33Abnormality of abdominal situs (HP:0011620)2.60943018
34Abdominal situs inversus (HP:0003363)2.60943018
35Septo-optic dysplasia (HP:0100842)2.52270104
36Specific learning disability (HP:0001328)2.50241157
37Poor suck (HP:0002033)2.49488396
38Vaginal atresia (HP:0000148)2.48266685
39Anal stenosis (HP:0002025)2.47762915
40Atrophy/Degeneration involving motor neurons (HP:0007373)2.46420294
41Synostosis of carpal bones (HP:0005048)2.42497556
42Anophthalmia (HP:0000528)2.42440797
43Esophageal atresia (HP:0002032)2.41475155
44Truncus arteriosus (HP:0001660)2.41458666
45Abnormality of the corticospinal tract (HP:0002492)2.41381499
46Retinal dysplasia (HP:0007973)2.40470179
47Limb dystonia (HP:0002451)2.40426540
48Genital tract atresia (HP:0001827)2.38236817
49Abnormality of the parathyroid morphology (HP:0011766)2.37843707
50Patellar aplasia (HP:0006443)2.36826296
51Abnormality of the anterior chamber (HP:0000593)2.36083244
52Rectovaginal fistula (HP:0000143)2.35714982
53Rectal fistula (HP:0100590)2.35714982
54Pseudobulbar signs (HP:0002200)2.34509607
55Ankyloglossia (HP:0010296)2.33958441
56Double outlet right ventricle (HP:0001719)2.32754881
57Congenital malformation of the right heart (HP:0011723)2.32754881
58Anosmia (HP:0000458)2.31232342
59Adrenal hypoplasia (HP:0000835)2.29789051
60Esotropia (HP:0000565)2.26792014
61Optic nerve coloboma (HP:0000588)2.26049304
62Heterochromia iridis (HP:0001100)2.23945690
63Degeneration of the lateral corticospinal tracts (HP:0002314)2.23631093
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.23631093
65Obsessive-compulsive behavior (HP:0000722)2.22728436
66Poor coordination (HP:0002370)2.21983612
67Hypoplasia of the fovea (HP:0007750)2.21885161
68Aplasia/Hypoplasia of the fovea (HP:0008060)2.21885161
69Renal hypoplasia (HP:0000089)2.21577187
70Carpal synostosis (HP:0009702)2.18795205
71Drooling (HP:0002307)2.18719230
72Growth hormone deficiency (HP:0000824)2.18179175
73Occipital encephalocele (HP:0002085)2.16852376
74Abnormality of the labia minora (HP:0012880)2.16310239
75Abnormality of the upper arm (HP:0001454)2.15751979
76Absent radius (HP:0003974)2.15619363
77Dysphonia (HP:0001618)2.15521459
78Deep palmar crease (HP:0006191)2.14252715
79Sleep apnea (HP:0010535)2.13930428
80Morphological abnormality of the middle ear (HP:0008609)2.13039973
81Uterine leiomyosarcoma (HP:0002891)2.10965255
82Leiomyosarcoma (HP:0100243)2.10965255
83Absent forearm bone (HP:0003953)2.10933962
84Aplasia involving forearm bones (HP:0009822)2.10933962
85Intestinal fistula (HP:0100819)2.10649180
86Intellectual disability, moderate (HP:0002342)2.10595483
87Labial hypoplasia (HP:0000066)2.10581639
88Agitation (HP:0000713)2.09622182
89True hermaphroditism (HP:0010459)2.09600145
90Abnormal pancreas size (HP:0012094)2.07530997
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.06387714
92Polymicrogyria (HP:0002126)2.06265396
93Ridged nail (HP:0001807)2.06143239
94Pancreatic fibrosis (HP:0100732)2.05769165
95Pendular nystagmus (HP:0012043)2.04364979
96Failure to thrive in infancy (HP:0001531)2.04194430
97Hypoplastic female external genitalia (HP:0012815)2.03710998
98Spastic tetraplegia (HP:0002510)2.03560622
99Abnormality of the lower motor neuron (HP:0002366)2.02803321
100Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.01687652
101Abnormal number of incisors (HP:0011064)1.99472362
102Increased number of teeth (HP:0011069)1.98964107
103Pachygyria (HP:0001302)1.98159918
104Nephronophthisis (HP:0000090)1.96792093
105Ectopic kidney (HP:0000086)1.96456005
106Cutaneous finger syndactyly (HP:0010554)1.95886723
107Vaginal fistula (HP:0004320)1.94532404
108Vitreoretinal degeneration (HP:0000655)1.94414281
109Hyperalaninemia (HP:0003348)1.94324172
110Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94324172
111Abnormality of alanine metabolism (HP:0010916)1.94324172
112Supranuclear gaze palsy (HP:0000605)1.94165949
113Gastrointestinal atresia (HP:0002589)1.94075147
114Anencephaly (HP:0002323)1.93973086
115Supernumerary ribs (HP:0005815)1.93937450
116Excessive salivation (HP:0003781)1.93732038
117Supernumerary spleens (HP:0009799)1.93499571
118Aplasia/Hypoplasia of the spleen (HP:0010451)1.93276082
119Micropenis (HP:0000054)1.92853217
120Sprengel anomaly (HP:0000912)1.91840903
121Cutaneous syndactyly (HP:0012725)1.91839609
122Diastasis recti (HP:0001540)1.91566127
123Renal dysplasia (HP:0000110)1.91247197
124Keratoconus (HP:0000563)1.89657872
125Increased corneal curvature (HP:0100692)1.89657872
126Abnormal eating behavior (HP:0100738)1.89279734
127Split foot (HP:0001839)1.89228719
128Aplasia/Hypoplasia of the sternum (HP:0006714)1.89228449
129Renal duplication (HP:0000075)1.88530174
130Horseshoe kidney (HP:0000085)1.87738793
131Chorioretinal coloboma (HP:0000567)1.87652583
132Long eyelashes (HP:0000527)1.86675345
133Molar tooth sign on MRI (HP:0002419)1.86473399
134Abnormality of midbrain morphology (HP:0002418)1.86473399
135Supernumerary bones of the axial skeleton (HP:0009144)1.85340064
136Midline defect of the nose (HP:0004122)1.84410879
137Optic nerve hypoplasia (HP:0000609)1.84040187
138Lissencephaly (HP:0001339)1.83552309
139Amyotrophic lateral sclerosis (HP:0007354)1.82924573
140Left ventricular hypertrophy (HP:0001712)1.82062116
141Anal atresia (HP:0002023)1.81916041
142Hip dysplasia (HP:0001385)1.81726439
143Asplenia (HP:0001746)1.81271571
144Neoplasm of the adrenal cortex (HP:0100641)1.80749944
145* Hemivertebrae (HP:0002937)1.80154057
146Hypoventilation (HP:0002791)1.78671026
147Pancreatic cysts (HP:0001737)1.78133984
148Congenital sensorineural hearing impairment (HP:0008527)1.77805756
149Neoplasm of the pancreas (HP:0002894)1.77698140
150Hypogonadotrophic hypogonadism (HP:0000044)1.77567816
151Abnormality of the renal medulla (HP:0100957)1.77355848
152* Rib fusion (HP:0000902)1.77287618
153Hypoplasia of the ulna (HP:0003022)1.77084674
154Sclerocornea (HP:0000647)1.76837066
155Preauricular skin tag (HP:0000384)1.75934660
156Abnormality of the fovea (HP:0000493)1.75454639
157Hyperglycinemia (HP:0002154)1.75452453
158Decreased testicular size (HP:0008734)1.75199140
159Broad alveolar ridges (HP:0000187)1.74838510
160Acute necrotizing encephalopathy (HP:0006965)1.74307597
161Aplasia/Hypoplasia of the breasts (HP:0010311)1.74249213
162Synostosis involving bones of the hand (HP:0004278)1.74098842
163Broad foot (HP:0001769)1.72819357
164Preaxial hand polydactyly (HP:0001177)1.72598138
165Shoulder girdle muscle weakness (HP:0003547)1.71921076
166Abnormal mitochondria in muscle tissue (HP:0008316)1.71268579
167Short 4th metacarpal (HP:0010044)1.71259838
168White forelock (HP:0002211)1.71083611
169Impaired vibration sensation in the lower limbs (HP:0002166)1.70541504
170Progressive macrocephaly (HP:0004481)1.69633616

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR25.92584527
2FGFR44.12426171
3TYRO33.84730291
4NTRK22.93179542
5EPHB22.87366506
6MAP2K72.78528261
7MAP3K42.77405633
8MKNK12.70488520
9MAP4K22.69911969
10CDK122.68641824
11SRPK12.55300458
12SIK32.47838964
13TGFBR12.45237010
14PDGFRA2.44810220
15DYRK32.39084383
16NEK62.37748034
17NTRK32.33731772
18ERBB32.30746622
19IRAK22.27060712
20CDK192.26174016
21BRD42.23020456
22KSR12.20525906
23WNK32.09173014
24CSNK1G21.94774482
25MARK11.89192422
26DYRK21.82416615
27FGFR31.81501830
28LATS21.78257070
29PASK1.77808231
30ADRBK21.75167902
31CSNK1A1L1.72461820
32YES11.71666280
33EPHA41.71497525
34BMPR1B1.63263076
35NTRK11.58690595
36ICK1.58109575
37PKN11.54942423
38CSNK1G11.49056808
39STK38L1.44442498
40BCR1.40847589
41FGFR11.39856793
42CDK71.36754224
43TLK11.36697520
44STK161.35231063
45PRKCG1.35230696
46SIK21.32742131
47TRIM281.31223257
48MARK21.29647685
49ACVR1B1.24700179
50BRSK11.24077891
51LMTK21.11020996
52MELK1.08421075
53MKNK21.04413303
54MAP2K41.04392103
55ITK1.00970480
56CDK51.00105832
57EPHA30.95849787
58PHKG10.94981658
59PHKG20.94981658
60GRK10.92844044
61CHEK20.92630680
62UHMK10.91655821
63NEK20.91548409
64PRKD30.91539033
65IRAK40.90126768
66CCNB10.90067981
67EIF2AK10.87112024
68AURKA0.86122616
69TSSK60.80791905
70CAMK2G0.79806614
71CDK80.78434575
72CDK140.78134893
73ERBB40.77714803
74PLK20.75115920
75PINK10.74895982
76PNCK0.74811206
77CAMK1G0.74245399
78CAMK1D0.73287679
79PAK30.70131116
80MINK10.69159199
81NEK10.68270330
82EIF2AK20.67727602
83CDK150.65749495
84RPS6KA40.64764670
85CAMK2B0.64466999
86ADRBK10.63838377
87ERBB20.62127995
88MAP3K90.61811375
89ATR0.60351179
90BCKDK0.59841088
91PAK60.56617876
92RPS6KA20.54821596
93ARAF0.53273327
94CAMK2A0.52563287
95CASK0.51981180
96CSNK1A10.50498141
97PLK30.49687432
98MAPK150.49161791
99CAMK10.48902153
100CDC42BPA0.48728337
101PRKAA10.47876905
102CSNK1D0.47662177
103SGK20.47113142
104MATK0.47053254
105PRKACA0.46870228
106DYRK1A0.46610101
107RPS6KA10.45263981
108RPS6KA50.45081583
109STK110.44716308
110BRAF0.44074035
111MAP3K60.43842566
112CAMK2D0.43576311
113NME10.43531513
114CDK30.42240746
115AURKB0.41873870
116PBK0.40912690
117MAPK110.40404079
118PRKCE0.39964910
119CHEK10.39782785
120ROCK20.39703602
121STK240.38933415
122INSRR0.38572460
123DYRK1B0.38436910
124IRAK10.38289160
125DAPK20.36340284
126RET0.36248317
127PRKCQ0.35068472
128CAMKK10.34323295
129BUB10.33683138
130PIM20.33172898
131CDK180.32934076
132PDGFRB0.31518757
133PRKDC0.30710282
134MAPK130.30708534
135PLK10.30295990
136CAMK40.29609449
137CDK10.29050484
138TESK20.28857314
139CHUK0.27596580
140LIMK10.27505993
141AKT20.27175293
142TAOK20.27042770
143PRKCZ0.24900717
144AKT10.22940676
145PRKD10.21787084
146MAPK70.21559041
147CSNK1E0.20674215
148DAPK30.20145383
149CDK11A0.18587678
150MAP3K100.18036513
151CSNK1G30.16836373
152SGK4940.16822235
153SGK2230.16822235
154CDK90.16334911
155CDK20.16046721

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.84585665
2* Notch signaling pathway_Homo sapiens_hsa043303.45955565
3Spliceosome_Homo sapiens_hsa030403.22861986
4Basal cell carcinoma_Homo sapiens_hsa052173.12389865
5Parkinsons disease_Homo sapiens_hsa050122.93614309
6Oxidative phosphorylation_Homo sapiens_hsa001902.87303261
7Non-homologous end-joining_Homo sapiens_hsa034502.61314219
8GABAergic synapse_Homo sapiens_hsa047272.58816550
9Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.46240012
10Synaptic vesicle cycle_Homo sapiens_hsa047212.34808706
11Hedgehog signaling pathway_Homo sapiens_hsa043402.27147178
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22525583
13RNA polymerase_Homo sapiens_hsa030202.16968707
14Cardiac muscle contraction_Homo sapiens_hsa042602.11687005
15Hippo signaling pathway_Homo sapiens_hsa043902.11517517
16Basal transcription factors_Homo sapiens_hsa030222.04923670
17Proteasome_Homo sapiens_hsa030502.04101698
18Morphine addiction_Homo sapiens_hsa050322.00812587
19Glutamatergic synapse_Homo sapiens_hsa047241.91526213
20DNA replication_Homo sapiens_hsa030301.90502616
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.89173749
22ErbB signaling pathway_Homo sapiens_hsa040121.87817012
23RNA transport_Homo sapiens_hsa030131.86634579
24Dopaminergic synapse_Homo sapiens_hsa047281.86362016
25mRNA surveillance pathway_Homo sapiens_hsa030151.86025574
26MicroRNAs in cancer_Homo sapiens_hsa052061.80811286
27Base excision repair_Homo sapiens_hsa034101.77815100
28Axon guidance_Homo sapiens_hsa043601.77542750
29Circadian entrainment_Homo sapiens_hsa047131.75208062
30Chronic myeloid leukemia_Homo sapiens_hsa052201.69861905
31Alzheimers disease_Homo sapiens_hsa050101.69531571
32Collecting duct acid secretion_Homo sapiens_hsa049661.67908290
33Cholinergic synapse_Homo sapiens_hsa047251.65319714
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.63767346
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.61932099
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56811038
37Non-small cell lung cancer_Homo sapiens_hsa052231.54019026
38Protein export_Homo sapiens_hsa030601.53155128
39Glioma_Homo sapiens_hsa052141.49262684
40Oocyte meiosis_Homo sapiens_hsa041141.49236721
41Melanogenesis_Homo sapiens_hsa049161.48145946
42Wnt signaling pathway_Homo sapiens_hsa043101.47599155
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.45639894
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.45477872
45Phototransduction_Homo sapiens_hsa047441.41985631
46Long-term depression_Homo sapiens_hsa047301.41743167
47Prion diseases_Homo sapiens_hsa050201.38592393
48Systemic lupus erythematosus_Homo sapiens_hsa053221.35764428
49Ribosome_Homo sapiens_hsa030101.32778432
50One carbon pool by folate_Homo sapiens_hsa006701.28845769
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26076789
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.22037539
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19060665
54Colorectal cancer_Homo sapiens_hsa052101.17532772
55Insulin secretion_Homo sapiens_hsa049111.16584118
56Epstein-Barr virus infection_Homo sapiens_hsa051691.13623800
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11764729
58Pyrimidine metabolism_Homo sapiens_hsa002401.11739483
59Gap junction_Homo sapiens_hsa045401.11666059
60Melanoma_Homo sapiens_hsa052181.11378875
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09777182
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08251788
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06710980
64Bladder cancer_Homo sapiens_hsa052191.05744307
65p53 signaling pathway_Homo sapiens_hsa041151.05655314
66Taste transduction_Homo sapiens_hsa047421.04433851
67Serotonergic synapse_Homo sapiens_hsa047261.03495303
68Sulfur relay system_Homo sapiens_hsa041221.03378088
69T cell receptor signaling pathway_Homo sapiens_hsa046601.02029603
70Alcoholism_Homo sapiens_hsa050340.99102268
71Renal cell carcinoma_Homo sapiens_hsa052110.97243992
72RNA degradation_Homo sapiens_hsa030180.96864240
73Proteoglycans in cancer_Homo sapiens_hsa052050.96510274
74Pathways in cancer_Homo sapiens_hsa052000.96290622
75Fanconi anemia pathway_Homo sapiens_hsa034600.95942279
76Nucleotide excision repair_Homo sapiens_hsa034200.94010188
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93381401
78Circadian rhythm_Homo sapiens_hsa047100.91923323
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88409285
80HTLV-I infection_Homo sapiens_hsa051660.87415279
81Arginine and proline metabolism_Homo sapiens_hsa003300.86901237
82Homologous recombination_Homo sapiens_hsa034400.84084854
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83525733
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83364891
85cAMP signaling pathway_Homo sapiens_hsa040240.82410507
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.81433255
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80929744
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80823503
89VEGF signaling pathway_Homo sapiens_hsa043700.78313295
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77925122
91Gastric acid secretion_Homo sapiens_hsa049710.77076334
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76804274
93Caffeine metabolism_Homo sapiens_hsa002320.75177677
94Lysine degradation_Homo sapiens_hsa003100.74326584
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.74313531
96Amphetamine addiction_Homo sapiens_hsa050310.73716313
97Propanoate metabolism_Homo sapiens_hsa006400.73165221
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.72910608
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71635358
100Olfactory transduction_Homo sapiens_hsa047400.70755920
101Regulation of autophagy_Homo sapiens_hsa041400.69820546
102Pancreatic cancer_Homo sapiens_hsa052120.69717633
103Fatty acid elongation_Homo sapiens_hsa000620.68620901
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68004638
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67489088
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64800072
107TGF-beta signaling pathway_Homo sapiens_hsa043500.64148760
108Mismatch repair_Homo sapiens_hsa034300.60081499
109Fatty acid metabolism_Homo sapiens_hsa012120.57856008
110AMPK signaling pathway_Homo sapiens_hsa041520.57000232
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56635625
112Herpes simplex infection_Homo sapiens_hsa051680.56316721
113Cocaine addiction_Homo sapiens_hsa050300.55098760
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54424348
115Inositol phosphate metabolism_Homo sapiens_hsa005620.54143778
116HIF-1 signaling pathway_Homo sapiens_hsa040660.54121386
117Small cell lung cancer_Homo sapiens_hsa052220.54059977
118Purine metabolism_Homo sapiens_hsa002300.53060143
119Oxytocin signaling pathway_Homo sapiens_hsa049210.50688295
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50208419
121Peroxisome_Homo sapiens_hsa041460.47983080
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47815668
123Shigellosis_Homo sapiens_hsa051310.47485218
124beta-Alanine metabolism_Homo sapiens_hsa004100.46482972
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46329233
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46059400
127Nicotine addiction_Homo sapiens_hsa050330.45584245
128Ras signaling pathway_Homo sapiens_hsa040140.44146128
129Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43973739
130Ether lipid metabolism_Homo sapiens_hsa005650.43479008
131Steroid biosynthesis_Homo sapiens_hsa001000.41926560
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41117152
133Endometrial cancer_Homo sapiens_hsa052130.40819392
134Choline metabolism in cancer_Homo sapiens_hsa052310.39391610
135Metabolic pathways_Homo sapiens_hsa011000.39364472
136Rap1 signaling pathway_Homo sapiens_hsa040150.38539761
137Huntingtons disease_Homo sapiens_hsa050160.37243192
138Tight junction_Homo sapiens_hsa045300.36982556
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36887671
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.36102920
141Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36031595
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34478929
143Biosynthesis of amino acids_Homo sapiens_hsa012300.33471854
144Dilated cardiomyopathy_Homo sapiens_hsa054140.33360772
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32587648
146Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31827529
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31549429
148Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30625369
149Butanoate metabolism_Homo sapiens_hsa006500.29667252
150NF-kappa B signaling pathway_Homo sapiens_hsa040640.29565347
151Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26797183
152Adherens junction_Homo sapiens_hsa045200.23244231
153Viral carcinogenesis_Homo sapiens_hsa052030.21474281
154Vibrio cholerae infection_Homo sapiens_hsa051100.21081778

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