DLL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)8.59133748
2vascular endothelial growth factor signaling pathway (GO:0038084)7.24457627
3endothelium development (GO:0003158)6.42987141
4positive regulation of vasculogenesis (GO:2001214)6.08982776
5lymphangiogenesis (GO:0001946)5.59609799
6* cellular response to vascular endothelial growth factor stimulus (GO:0035924)5.45322567
7blood vessel maturation (GO:0001955)5.43310522
8surfactant homeostasis (GO:0043129)5.40473046
9retina vasculature morphogenesis in camera-type eye (GO:0061299)5.36736410
10regulation of vasculogenesis (GO:2001212)5.32901152
11heart valve formation (GO:0003188)5.15488105
12regulation of endothelial cell differentiation (GO:0045601)4.98222331
13endothelial cell morphogenesis (GO:0001886)4.97059646
14angiogenesis involved in wound healing (GO:0060055)4.96928513
15vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.52143981
16endothelial cell differentiation (GO:0045446)4.36061412
17bundle of His cell to Purkinje myocyte communication (GO:0086069)4.30628691
18cell migration involved in sprouting angiogenesis (GO:0002042)4.27791574
19ovulation from ovarian follicle (GO:0001542)4.20596040
20chemical homeostasis within a tissue (GO:0048875)4.19488184
21heart trabecula formation (GO:0060347)4.18862231
22blood vessel endothelial cell migration (GO:0043534)4.05423441
23peptidyl-tyrosine autophosphorylation (GO:0038083)4.05342209
24transcytosis (GO:0045056)4.03538141
25* patterning of blood vessels (GO:0001569)3.93258623
26basement membrane organization (GO:0071711)3.92131990
27wound healing, spreading of epidermal cells (GO:0035313)3.71961569
28vasculogenesis (GO:0001570)3.68787383
29venous blood vessel morphogenesis (GO:0048845)3.61861537
30sprouting angiogenesis (GO:0002040)3.56362850
31labyrinthine layer development (GO:0060711)3.54667044
32negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.51385274
33establishment of endothelial barrier (GO:0061028)3.49963692
34* regulation of blood vessel endothelial cell migration (GO:0043535)3.49412644
35* Notch signaling involved in heart development (GO:0061314)3.48837866
36renal filtration (GO:0097205)3.43664955
37glomerular filtration (GO:0003094)3.38672789
38negative regulation of cell junction assembly (GO:1901889)3.37581396
39negative regulation of adherens junction organization (GO:1903392)3.37581396
40negative regulation of focal adhesion assembly (GO:0051895)3.37581396
41embryonic heart tube development (GO:0035050)3.35198448
42negative regulation of endothelial cell apoptotic process (GO:2000352)3.32054598
43growth hormone receptor signaling pathway (GO:0060396)3.27005608
44positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.24457023
45regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.24451068
46endothelial cell proliferation (GO:0001935)3.22432350
47coronary vasculature morphogenesis (GO:0060977)3.18196793
48endothelial cell migration (GO:0043542)3.14337719
49substrate-dependent cell migration (GO:0006929)3.11644383
50regulation of p38MAPK cascade (GO:1900744)3.10769794
51endothelial cell chemotaxis (GO:0035767)3.09909730
52artery development (GO:0060840)3.08807357
53cardiac myofibril assembly (GO:0055003)3.08185940
54regulation of vascular permeability (GO:0043114)3.07740177
55sarcomere organization (GO:0045214)3.04998358
56regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.00328408
57negative regulation of vascular permeability (GO:0043116)2.99862823
58positive regulation of lipid kinase activity (GO:0090218)2.99042672
59monocyte chemotaxis (GO:0002548)2.95662463
60positive regulation of endothelial cell differentiation (GO:0045603)2.94634500
61endocardial cushion morphogenesis (GO:0003203)2.93578888
62* negative regulation of epithelial cell migration (GO:0010633)2.91629988
63positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.90668729
64regulation of endothelial cell apoptotic process (GO:2000351)2.88247962
65plasma membrane repair (GO:0001778)2.87729060
66positive regulation of p38MAPK cascade (GO:1900745)2.87607552
67* endothelial tube morphogenesis (GO:0061154)2.85842200
68* morphogenesis of an endothelium (GO:0003159)2.85842200
69atrial cardiac muscle cell action potential (GO:0086014)2.85202725
70positive regulation of focal adhesion assembly (GO:0051894)2.85162787
71positive regulation of cell junction assembly (GO:1901890)2.85162787
72* blood vessel morphogenesis (GO:0048514)2.84959269
73* negative regulation of angiogenesis (GO:0016525)2.84429830
74dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.82548309
75fatty acid transmembrane transport (GO:1902001)2.82009040
76regulation of cell-substrate junction assembly (GO:0090109)2.81416358
77regulation of focal adhesion assembly (GO:0051893)2.81416358
78adhesion of symbiont to host (GO:0044406)2.80406496
79antigen processing and presentation of endogenous antigen (GO:0019883)2.79801322
80trabecula formation (GO:0060343)2.79559876
81cellular response to growth hormone stimulus (GO:0071378)2.78849591
82negative regulation of platelet activation (GO:0010544)2.78379369
83regulation of adherens junction organization (GO:1903391)2.77825240
84low-density lipoprotein particle clearance (GO:0034383)2.77800809
85positive regulation of adherens junction organization (GO:1903393)2.76219565
86* negative regulation of blood vessel endothelial cell migration (GO:0043537)2.75569379
87regulation of positive chemotaxis (GO:0050926)2.74799134
88neuron remodeling (GO:0016322)2.74290842
89* negative regulation of blood vessel morphogenesis (GO:2000181)2.73735169
90positive regulation of odontogenesis (GO:0042482)2.73210193
91cardiac muscle cell proliferation (GO:0060038)2.71899062
92* negative regulation of endothelial cell migration (GO:0010596)2.71881732
93gap junction assembly (GO:0016264)2.71672053
94hyaluronan catabolic process (GO:0030214)2.71327565
95negative regulation of Rho protein signal transduction (GO:0035024)2.71088581
96negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.71068935
97positive regulation of macrophage cytokine production (GO:0060907)2.70521447
98calcium-mediated signaling using intracellular calcium source (GO:0035584)2.70406163
99nephron epithelium development (GO:0072009)2.70317497
100positive regulation of urine volume (GO:0035810)2.70282932
101outflow tract morphogenesis (GO:0003151)2.69587348
102positive regulation of protein kinase C signaling (GO:0090037)2.69051147
103antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.68942319
104antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.68942319
105hormone catabolic process (GO:0042447)2.66987267
106semaphorin-plexin signaling pathway (GO:0071526)2.65431539
107myofibril assembly (GO:0030239)2.64649065
108* negative regulation of vasculature development (GO:1901343)2.61375282
109vasculature development (GO:0001944)2.61171353
110epithelial cell migration (GO:0010631)2.60403957
111ovulation (GO:0030728)2.58862530
112cell migration involved in heart development (GO:0060973)2.58320598
113regulation of actin filament-based movement (GO:1903115)2.57021102
114positive regulation of endothelial cell proliferation (GO:0001938)2.56570695
115negative regulation of endothelial cell proliferation (GO:0001937)2.55747831
116* regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.55019537
117embryonic foregut morphogenesis (GO:0048617)2.53888381
118cAMP biosynthetic process (GO:0006171)2.51531906
119negative regulation of potassium ion transmembrane transport (GO:1901380)2.51471218
120Rap protein signal transduction (GO:0032486)2.51182018
121* angiogenesis (GO:0001525)2.50419011
122positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.49738257
123* regulation of epithelial cell migration (GO:0010632)2.49632526
124protein localization to endosome (GO:0036010)2.48683086
125phagocytosis, recognition (GO:0006910)2.47701911
126protein kinase C signaling (GO:0070528)2.47578288
127negative regulation of nitric-oxide synthase activity (GO:0051001)2.47172009
128* regulation of endothelial cell migration (GO:0010594)2.46300936
129regulation of sarcomere organization (GO:0060297)2.45091818
130* blood vessel remodeling (GO:0001974)2.44792525
131positive regulation of Rap GTPase activity (GO:0032854)2.44218445
132carnitine shuttle (GO:0006853)2.43714529
133regulation of cardioblast differentiation (GO:0051890)2.43558708
134negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.42679676
135neuron projection extension involved in neuron projection guidance (GO:1902284)2.40972592
136axon extension involved in axon guidance (GO:0048846)2.40972592
137positive regulation of endothelial cell migration (GO:0010595)2.40764206
138mRNA transcription (GO:0009299)2.40642409
139endoderm formation (GO:0001706)2.40284765
140positive regulation of histone deacetylation (GO:0031065)2.40227238
141exocrine pancreas development (GO:0031017)2.39997890
142mRNA transcription from RNA polymerase II promoter (GO:0042789)2.38639199

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.44411909
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.76018141
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.22168090
4CLOCK_20551151_ChIP-Seq_293T_Human3.21865006
5GATA2_21666600_ChIP-Seq_HMVEC_Human3.11239784
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.04803631
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.92703867
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.61439201
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.54256528
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.44691938
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.26440672
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.16323002
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.14233612
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.14105255
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.10510941
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.09918858
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.09918858
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.09918858
19ZNF263_19887448_ChIP-Seq_K562_Human2.08459393
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.05981600
21GATA1_22025678_ChIP-Seq_K562_Human2.05320671
22RXR_22158963_ChIP-Seq_LIVER_Mouse2.04410399
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.96307582
24* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.94119970
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.92181749
26* EED_16625203_ChIP-ChIP_MESCs_Mouse1.91916687
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.88565844
28PPARA_22158963_ChIP-Seq_LIVER_Mouse1.87070875
29TBX20_22328084_ChIP-Seq_HEART_Mouse1.85488220
30TBX20_22080862_ChIP-Seq_HEART_Mouse1.85488220
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.84737949
32ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.76568769
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75561426
34NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.72914491
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.70205257
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69912795
37CDX2_20551321_ChIP-Seq_CACO-2_Human1.66091866
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.64570794
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.64239534
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63030799
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.59497167
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58454559
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.56730161
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52707288
45GATA1_19941826_ChIP-Seq_K562_Human1.47098972
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.46146121
47* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44089694
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42103617
49* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40908951
50SALL4_18804426_ChIP-ChIP_XEN_Mouse1.40121753
51* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38396836
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36882064
53* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33905893
54* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.33703457
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.32222206
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32186685
57* KDM2B_26808549_Chip-Seq_K562_Human1.32051209
58* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31906258
59SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31356005
60* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30930890
61KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30863991
62SCL_19346495_ChIP-Seq_HPC-7_Human1.28605999
63* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27763837
64RACK7_27058665_Chip-Seq_MCF-7_Human1.26803885
65SOX2_20726797_ChIP-Seq_SW620_Human1.25721037
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25714364
67* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22918142
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.22799867
69* EZH2_27294783_Chip-Seq_ESCs_Mouse1.17914336
70RING1B_27294783_Chip-Seq_ESCs_Mouse1.16496282
71* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15267650
72CJUN_26792858_Chip-Seq_BT549_Human1.13160541
73* RNF2_27304074_Chip-Seq_ESCs_Mouse1.12126368
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11591955
75* KDM2B_26808549_Chip-Seq_DND41_Human1.11351424
76NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09663607
77* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09549075
78* LXR_22292898_ChIP-Seq_THP-1_Human1.08779486
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08348273
80TCF7_22412390_ChIP-Seq_EML_Mouse1.07597749
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07233709
82SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07050913
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06229117
84FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.05550983
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05105678
86* TP53_20018659_ChIP-ChIP_R1E_Mouse1.04847130
87SMC3_22415368_ChIP-Seq_MEFs_Mouse1.04376030
88* EZH2_27304074_Chip-Seq_ESCs_Mouse1.02148913
89DROSHA_22980978_ChIP-Seq_HELA_Human1.00850249
90SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00731412
91* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99901126
92PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99627102
93SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99594051
94CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98090411
95RUNX1_27514584_Chip-Seq_MCF-7_Human0.97815280
96EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97220986
97SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97041498
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97041498
99* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95193889
100SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94868633
101CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93962068
102AHR_22903824_ChIP-Seq_MCF-7_Human0.93915797
103ISL1_27105846_Chip-Seq_CPCs_Mouse0.93499481
104FOXA2_19822575_ChIP-Seq_HepG2_Human0.91913126
105* KDM2B_26808549_Chip-Seq_JURKAT_Human0.91812257
106TCF4_18268006_ChIP-ChIP_LS174T_Human0.91642102
107NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91344234
108FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91029580
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90174066
110JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88766654
111GATA2_19941826_ChIP-Seq_K562_Human0.88341007
112IRF8_22096565_ChIP-ChIP_GC-B_Human0.88126017
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.87735775
114P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86637309
115TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86093133
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86072574
117* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85922304
118WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85646257
119* NCOR1_26117541_ChIP-Seq_K562_Human0.85493369
120* RING1B_27294783_Chip-Seq_NPCs_Mouse0.85235884
121FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.85165132
122* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.82815928
123* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.82815928
124JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82660858
125SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82618896
126EGR1_19374776_ChIP-ChIP_THP-1_Human0.82464234
127TET1_21490601_ChIP-Seq_MESCs_Mouse0.82266634
128ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82227578
129NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82032059
130NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82032059
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81400756
132MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.81236017
133* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.81120169
134BRD4_25478319_ChIP-Seq_HGPS_Human0.80488274

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system7.46854522
2MP0001879_abnormal_lymphatic_vessel5.72363800
3MP0005167_abnormal_blood-brain_barrier4.80926933
4MP0004272_abnormal_basement_membrane4.34065236
5MP0004084_abnormal_cardiac_muscle3.38417681
6MP0000465_gastrointestinal_hemorrhage3.10354837
7MP0003828_pulmonary_edema2.72136373
8MP0003724_increased_susceptibility_to2.66868514
9MP0005409_darkened_coat_color2.61841739
10MP0004215_abnormal_myocardial_fiber2.38011810
11MP0002138_abnormal_hepatobiliary_system2.37677637
12MP0006054_spinal_hemorrhage2.31087514
13MP0003705_abnormal_hypodermis_morpholog2.29704878
14MP0006138_congestive_heart_failure2.17159990
15MP0004036_abnormal_muscle_relaxation2.13022912
16MP0002837_dystrophic_cardiac_calcinosis2.07440199
17MP0002254_reproductive_system_inflammat1.98665299
18MP0000013_abnormal_adipose_tissue1.90949547
19MP0005330_cardiomyopathy1.87417336
20MP0005623_abnormal_meninges_morphology1.78185915
21MP0003300_gastrointestinal_ulcer1.76753532
22MP0002127_abnormal_cardiovascular_syste1.73289271
23MP0008775_abnormal_heart_ventricle1.72013700
24MP0002332_abnormal_exercise_endurance1.64243365
25MP0001544_abnormal_cardiovascular_syste1.60832431
26MP0005385_cardiovascular_system_phenoty1.60832431
27* MP0000767_abnormal_smooth_muscle1.57589379
28MP0005165_increased_susceptibility_to1.56422785
29MP0002972_abnormal_cardiac_muscle1.54590570
30MP0000537_abnormal_urethra_morphology1.54091798
31* MP0010630_abnormal_cardiac_muscle1.51611496
32MP0003566_abnormal_cell_adhesion1.49291231
33MP0003279_aneurysm1.47559280
34MP0000751_myopathy1.47262300
35MP0004085_abnormal_heartbeat1.45682911
36MP0000343_altered_response_to1.41050270
37MP0000249_abnormal_blood_vessel1.39711487
38MP0004484_altered_response_of1.36157911
39MP0005360_urolithiasis1.35010316
40MP0004130_abnormal_muscle_cell1.32782211
41MP0004510_myositis1.31497452
42* MP0002925_abnormal_cardiovascular_devel1.29451463
43* MP0002128_abnormal_blood_circulation1.28562870
44MP0009278_abnormal_bone_marrow1.27901122
45MP0009053_abnormal_anal_canal1.27607834
46MP0005620_abnormal_muscle_contractility1.27364148
47MP0002933_joint_inflammation1.26614381
48MP0002295_abnormal_pulmonary_circulatio1.25918648
49MP0004147_increased_porphyrin_level1.22549323
50MP0001849_ear_inflammation1.21749085
51MP0005670_abnormal_white_adipose1.20890278
52MP0005595_abnormal_vascular_smooth1.19955933
53MP0004087_abnormal_muscle_fiber1.18438211
54MP0000749_muscle_degeneration1.12034678
55* MP0001614_abnormal_blood_vessel1.11458651
56MP0000750_abnormal_muscle_regeneration1.09813064
57MP0003091_abnormal_cell_migration1.07179936
58MP0003303_peritoneal_inflammation1.05953631
59MP0005084_abnormal_gallbladder_morpholo1.04648547
60MP0003191_abnormal_cellular_cholesterol1.03106121
61MP0004782_abnormal_surfactant_physiolog1.00698615
62* MP0000266_abnormal_heart_morphology1.00653896
63MP0005085_abnormal_gallbladder_physiolo0.97258078
64MP0004883_abnormal_blood_vessel0.96259275
65MP0000003_abnormal_adipose_tissue0.93944891
66MP0004264_abnormal_extraembryonic_tissu0.93789764
67MP0008961_abnormal_basal_metabolism0.93512039
68MP0005164_abnormal_response_to0.89471889
69MP0001958_emphysema0.88562490
70MP0005666_abnormal_adipose_tissue0.88427453
71MP0000230_abnormal_systemic_arterial0.88175553
72MP0001915_intracranial_hemorrhage0.88051206
73MP0002139_abnormal_hepatobiliary_system0.85231947
74MP0005375_adipose_tissue_phenotype0.84196336
75MP0010234_abnormal_vibrissa_follicle0.83924776
76MP0003122_maternal_imprinting0.82421666
77MP0003252_abnormal_bile_duct0.82099897
78MP0010329_abnormal_lipoprotein_level0.80621610
79MP0008004_abnormal_stomach_pH0.80405312
80MP0009379_abnormal_foot_pigmentation0.79569827
81MP0008438_abnormal_cutaneous_collagen0.76128862
82MP0003137_abnormal_impulse_conducting0.76002873
83MP0003045_fibrosis0.75547314
84MP0005365_abnormal_bile_salt0.74534987
85MP0003943_abnormal_hepatobiliary_system0.74268829
86MP0004185_abnormal_adipocyte_glucose0.74053032
87* MP0001784_abnormal_fluid_regulation0.73297311
88MP0000516_abnormal_urinary_system0.69345602
89MP0005367_renal/urinary_system_phenotyp0.69345602
90MP0005187_abnormal_penis_morphology0.68633194
91MP0009764_decreased_sensitivity_to0.68376611
92MP0002106_abnormal_muscle_physiology0.68060342
93MP0003315_abnormal_perineum_morphology0.67408632
94MP0009643_abnormal_urine_homeostasis0.67195596
95MP0003950_abnormal_plasma_membrane0.65409951
96MP0003646_muscle_fatigue0.65165417
97MP0001851_eye_inflammation0.65027996
98MP0009840_abnormal_foam_cell0.64649871
99* MP0002086_abnormal_extraembryonic_tissu0.61916730
100MP0005023_abnormal_wound_healing0.61480269
101MP0002877_abnormal_melanocyte_morpholog0.60753580
102* MP0002088_abnormal_embryonic_growth/wei0.60680201
103MP0005319_abnormal_enzyme/_coenzyme0.59390766
104MP0005058_abnormal_lysosome_morphology0.59083938
105* MP0003984_embryonic_growth_retardation0.58619924
106MP0004885_abnormal_endolymph0.57571377
107MP0005369_muscle_phenotype0.56184686
108MP0001270_distended_abdomen0.55937967
109MP0000609_abnormal_liver_physiology0.55757373
110MP0000733_abnormal_muscle_development0.55541453
111MP0008875_abnormal_xenobiotic_pharmacok0.55154544
112MP0001533_abnormal_skeleton_physiology0.55153230
113MP0005451_abnormal_body_composition0.53532792
114MP0010352_gastrointestinal_tract_polyps0.52823561
115MP0003948_abnormal_gas_homeostasis0.50420883
116MP0004145_abnormal_muscle_electrophysio0.46979978
117MP0010155_abnormal_intestine_physiology0.44196919
118MP0004808_abnormal_hematopoietic_stem0.44099906
119MP0001542_abnormal_bone_strength0.43229942
120MP0002998_abnormal_bone_remodeling0.42696514
121MP0002896_abnormal_bone_mineralization0.42433458
122MP0001191_abnormal_skin_condition0.42110706
123MP0000467_abnormal_esophagus_morphology0.41434239
124MP0008874_decreased_physiological_sensi0.41203247
125MP0005193_abnormal_anterior_eye0.41005600
126MP0002108_abnormal_muscle_morphology0.39300755
127MP0002133_abnormal_respiratory_system0.37090100
128MP0005388_respiratory_system_phenotype0.37090100
129MP0003119_abnormal_digestive_system0.36313067

Predicted human phenotypes

RankGene SetZ-score
1Polycythemia (HP:0001901)6.05271885
2Hematochezia (HP:0002573)4.91500936
3Ventricular tachycardia (HP:0004756)4.88032818
4Esophageal varix (HP:0002040)4.86164464
5Spontaneous hematomas (HP:0007420)4.76301195
6Abnormality of the nasal mucosa (HP:0000433)4.33646158
7Increased connective tissue (HP:0009025)4.18743203
8Lymphangioma (HP:0100764)4.13021801
9Muscle fiber splitting (HP:0003555)4.07742126
10Sudden death (HP:0001699)3.99849569
11Capillary hemangiomas (HP:0005306)3.85262550
12Right ventricular cardiomyopathy (HP:0011663)3.83393100
13Nonimmune hydrops fetalis (HP:0001790)3.72636058
14Atrial fibrillation (HP:0005110)3.64965781
15Premature rupture of membranes (HP:0001788)3.63112642
16Cerebral hemorrhage (HP:0001342)3.58800385
17Cerebral aneurysm (HP:0004944)3.50194952
18Hypoglycemic coma (HP:0001325)3.48141400
19Supraventricular arrhythmia (HP:0005115)3.48121410
20Deep venous thrombosis (HP:0002625)3.47291504
21Hypoplasia of the iris (HP:0007676)3.39971840
22Primary atrial arrhythmia (HP:0001692)3.36630892
23Broad metatarsal (HP:0001783)3.36194360
24Exercise-induced muscle cramps (HP:0003710)3.32316814
25Hyporeflexia of lower limbs (HP:0002600)3.28423277
26Visceral angiomatosis (HP:0100761)3.27198010
27Hyperinsulinemic hypoglycemia (HP:0000825)3.26407752
28Difficulty running (HP:0009046)3.21511414
29Supraventricular tachycardia (HP:0004755)3.20043405
30Hemangiomatosis (HP:0007461)3.05110107
31Arterial tortuosity (HP:0005116)3.03188107
32Vascular tortuosity (HP:0004948)2.98251648
33Hemiparesis (HP:0001269)2.87377843
34Porencephaly (HP:0002132)2.83651540
35Atrioventricular block (HP:0001678)2.83369104
36Lipoatrophy (HP:0100578)2.82999366
37Conjunctival telangiectasia (HP:0000524)2.80461953
38Wrist flexion contracture (HP:0001239)2.77316251
39Hemorrhage of the eye (HP:0011885)2.76151556
40Aneurysm (HP:0002617)2.74762648
41Abnormality of the intrinsic pathway (HP:0010989)2.73622926
42Adactyly (HP:0009776)2.71067169
43Portal hypertension (HP:0001409)2.69697939
44Hydroureter (HP:0000072)2.62888300
45Enlarged penis (HP:0000040)2.57704110
46Cavernous hemangioma (HP:0001048)2.51879995
47Limb dystonia (HP:0002451)2.50780533
48Scotoma (HP:0000575)2.50089971
49Syncope (HP:0001279)2.47025793
50Type 1 muscle fiber predominance (HP:0003803)2.45710064
51Pancreatic islet-cell hyperplasia (HP:0004510)2.44984617
52Pulmonary hypertension (HP:0002092)2.43983756
53Hypoglycemic seizures (HP:0002173)2.42369139
54EMG: myopathic abnormalities (HP:0003458)2.42023072
55Absent hand (HP:0004050)2.39737664
56Myoglobinuria (HP:0002913)2.39282198
57Ketoacidosis (HP:0001993)2.37205117
58Dilated cardiomyopathy (HP:0001644)2.35470447
59Increased variability in muscle fiber diameter (HP:0003557)2.34458913
60Abnormality of the vasculature of the conjunctiva (HP:0008054)2.32660694
61Abnormality of the hepatic vasculature (HP:0006707)2.32436817
62Interstitial pulmonary disease (HP:0006530)2.30465380
63Skull defect (HP:0001362)2.30236564
64Reduced subcutaneous adipose tissue (HP:0003758)2.29776315
65Aortic dissection (HP:0002647)2.27787795
66Difficulty climbing stairs (HP:0003551)2.27596612
67Heart block (HP:0012722)2.26878367
68Exercise-induced myalgia (HP:0003738)2.26659944
69Myotonia (HP:0002486)2.24435161
70Palpitations (HP:0001962)2.23882478
71Myocardial infarction (HP:0001658)2.23134917
72Abnormal atrioventricular conduction (HP:0005150)2.22171421
73Exotropia (HP:0000577)2.20638598
74Prolonged QT interval (HP:0001657)2.20278428
75Overgrowth (HP:0001548)2.20198694
76Abnormality of skeletal muscle fiber size (HP:0012084)2.20153949
77Tetraparesis (HP:0002273)2.20002735
78Calf muscle hypertrophy (HP:0008981)2.18747052
79Joint hemorrhage (HP:0005261)2.17186056
80Congenital, generalized hypertrichosis (HP:0004540)2.16647085
81Aortic aneurysm (HP:0004942)2.16439882
82Short hallux (HP:0010109)2.14881730
83Delayed CNS myelination (HP:0002188)2.14628022
84Stroke (HP:0001297)2.13220820
85Nuclear cataract (HP:0100018)2.13205579
86Vascular calcification (HP:0004934)2.10983689
87Neonatal death (HP:0003811)2.06563861
88Lymphedema (HP:0001004)2.02768925
89Aplasia/Hypoplasia of the hallux (HP:0008362)2.02694585
90Mildly elevated creatine phosphokinase (HP:0008180)2.02313972
91Mucosal telangiectasiae (HP:0100579)2.01859064
92Cardiovascular calcification (HP:0011915)2.01548369
93Distal lower limb muscle weakness (HP:0009053)2.00381742
94Shallow orbits (HP:0000586)1.99428085
95Venous abnormality (HP:0002624)1.99162090
96Hypoplastic ischia (HP:0003175)1.95892336
97Hypoalphalipoproteinemia (HP:0003233)1.95736839
98Joint contractures involving the joints of the feet (HP:0100492)1.93698094
99Flexion contracture of toe (HP:0005830)1.93698094
100Polygenic inheritance (HP:0010982)1.93615997
101Pulmonary artery stenosis (HP:0004415)1.92909257
102Asymmetric septal hypertrophy (HP:0001670)1.92733187
103Muscle stiffness (HP:0003552)1.92145448
104Mesangial abnormality (HP:0001966)1.91982109
105Venous insufficiency (HP:0005293)1.91303953
106Ventricular arrhythmia (HP:0004308)1.91129827
107Testicular atrophy (HP:0000029)1.91124072
108Mitral valve prolapse (HP:0001634)1.90913061
109Pigmentary retinal degeneration (HP:0001146)1.90622369
110Facial diplegia (HP:0001349)1.90526522
111Abnormality of endocrine pancreas physiology (HP:0012093)1.89973550
112Abnormality of the pancreatic islet cells (HP:0006476)1.89973550
113Growth hormone excess (HP:0000845)1.89796337
114Facial shape deformation (HP:0011334)1.89609053
115Potter facies (HP:0002009)1.89609053
116Areflexia of lower limbs (HP:0002522)1.88764376
117Bulbar palsy (HP:0001283)1.88734588
118Hemiplegia (HP:0002301)1.88540203
119Muscle hypertrophy of the lower extremities (HP:0008968)1.88386728
120Abnormality of the ischium (HP:0003174)1.86478705
121Abnormality of the calf musculature (HP:0001430)1.85841951
122Insulin-resistant diabetes mellitus (HP:0000831)1.84887113
123Abnormality of the left ventricular outflow tract (HP:0011103)1.84493103
124Subaortic stenosis (HP:0001682)1.84493103
125Spinal rigidity (HP:0003306)1.84269129
126Absent toe (HP:0010760)1.83607567
127Hyperglycemia (HP:0003074)1.83137100
128Congenital cataract (HP:0000519)1.81611418
129Distal lower limb amyotrophy (HP:0008944)1.80908166
130Camptodactyly of toe (HP:0001836)1.80561618
131Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.79590981
132Short 4th metacarpal (HP:0010044)1.79590981
133Large for gestational age (HP:0001520)1.78180718
134Absent eyebrow (HP:0002223)1.77689532
135Ventricular fibrillation (HP:0001663)1.77591843
136Protrusio acetabuli (HP:0003179)1.77338685
137Amblyopia (HP:0000646)1.76971018
138Ketosis (HP:0001946)1.75536382
139Acanthosis nigricans (HP:0000956)1.74232400
140Rectal prolapse (HP:0002035)1.72803385
141Axonal loss (HP:0003447)1.71703406
142Distal arthrogryposis (HP:0005684)1.71233891
143Thick nail (HP:0001805)1.70541061
144Hip contracture (HP:0003273)1.69702134
145Abnormality of the vitreous humor (HP:0004327)1.69110065
146Ectopia lentis (HP:0001083)1.68105526
147Centrally nucleated skeletal muscle fibers (HP:0003687)1.67123703
148Thin ribs (HP:0000883)1.64850613
149Wormian bones (HP:0002645)1.61560408

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.42083164
2KDR7.11338379
3TGFBR23.89578736
4ERN12.53675709
5RIPK12.27329101
6TGFBR12.25380629
7GRK12.06755789
8TSSK62.05523190
9EPHB22.01908193
10FES2.01137484
11EPHB11.86799102
12TTN1.80125876
13PTK2B1.77701481
14FGFR41.74381093
15TRIB31.54620751
16PRKG21.51237991
17INSRR1.46569936
18MAPK151.46285617
19PTK61.44949384
20MYLK1.39717005
21FER1.33493438
22EPHA31.26344832
23PKN21.18640482
24DMPK1.18286216
25NTRK11.12901717
26FGFR31.07679005
27PDGFRA1.01073443
28MAP2K31.00951608
29IRAK31.00310956
30LMTK20.96863777
31PTK20.95272973
32GRK50.94994430
33TBK10.88081276
34SIK10.86564885
35MAP3K30.83812365
36JAK10.82321991
37PAK40.82296211
38MAP3K140.79171098
39MAPK120.79076947
40JAK30.78918055
41CSK0.78513024
42LATS20.77501080
43MAP3K100.75827210
44PRKAA20.74527577
45PRKD10.74493382
46PHKG20.73279781
47PHKG10.73279781
48MAP3K10.71266144
49EPHA20.71261566
50TYK20.70130343
51MAPK70.68602773
52MAP2K20.68360021
53WNK40.67113175
54MOS0.65982205
55STK100.65853614
56MUSK0.64584193
57CDK120.63877786
58PDK20.61486188
59JAK20.60869292
60OBSCN0.58905016
61RPS6KA20.58706980
62BCKDK0.57842100
63TRPM70.57443521
64LRRK20.56444904
65CAMK40.54263231
66ZAP700.54133428
67MET0.53724307
68RET0.53207233
69PRKD20.52283620
70WNK10.51567485
71MAP3K70.51488770
72GSK3A0.50144830
73AKT30.47302833
74NLK0.46815775
75IGF1R0.46444113
76GRK60.45425731
77ARAF0.43717947
78PIK3CA0.42340307
79LATS10.42315393
80MARK20.41304523
81DDR20.41270026
82PRKCH0.40674849
83TESK10.40213175
84MAP2K10.40202177
85ROCK20.39818855
86PIK3CG0.39769668
87CDC42BPA0.39014335
88GRK70.38359585
89MAP3K130.37857190
90PAK30.37556592
91IKBKE0.37078789
92EGFR0.36677777
93PDGFRB0.36106336
94PRKD30.34946368
95MAP3K110.34254024
96MAPK40.34123349
97PRKAA10.33946210
98CHUK0.33793274
99SRC0.33777589
100ITK0.33393477
101PAK20.31820265
102EEF2K0.31471466
103ERBB40.28888003
104MTOR0.28572424
105IRAK10.27739343
106MARK30.27401393
107MATK0.27258368
108ABL20.26419546
109HIPK20.26267216
110DYRK1B0.26262234
111FLT30.25645582
112TYRO30.24551421
113TEC0.24291628
114PRKCE0.24112349
115CAMK1G0.23689525
116PRPF4B0.23602361
117FGFR20.23495641
118INSR0.22534377
119BCR0.22371872
120CAMK1D0.21400308
121MAP4K10.20675115
122ICK0.19998334
123ROCK10.19690847
124PDPK10.18890818
125CSF1R0.17941226
126CDK90.17560849
127MAPKAPK30.17515384
128ILK0.17457139
129BMX0.15974293
130STK390.14628420
131HCK0.14507111
132PNCK0.13029721
133AKT20.12099202
134DAPK30.11188119
135RPS6KC10.11097219
136RPS6KL10.11097219

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.05743590
2Dilated cardiomyopathy_Homo sapiens_hsa054142.13989803
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.11809456
4Focal adhesion_Homo sapiens_hsa045102.08526256
5ECM-receptor interaction_Homo sapiens_hsa045122.08275369
6Fatty acid degradation_Homo sapiens_hsa000712.03500320
7Arginine biosynthesis_Homo sapiens_hsa002201.95883309
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.95857308
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.91067992
10Adherens junction_Homo sapiens_hsa045201.82679846
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82566093
12Complement and coagulation cascades_Homo sapiens_hsa046101.80503644
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.79926597
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.77584891
15Tryptophan metabolism_Homo sapiens_hsa003801.75431449
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74567216
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.74295007
18PPAR signaling pathway_Homo sapiens_hsa033201.66169344
19Dorso-ventral axis formation_Homo sapiens_hsa043201.62628967
20Bile secretion_Homo sapiens_hsa049761.54303369
21Insulin resistance_Homo sapiens_hsa049311.50675050
22Small cell lung cancer_Homo sapiens_hsa052221.46371377
23Propanoate metabolism_Homo sapiens_hsa006401.45627117
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43943904
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.30839981
26Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.29119998
27Pertussis_Homo sapiens_hsa051331.24225232
28Fatty acid metabolism_Homo sapiens_hsa012121.23161599
29Rap1 signaling pathway_Homo sapiens_hsa040151.22955836
30Caffeine metabolism_Homo sapiens_hsa002321.21928582
31Nitrogen metabolism_Homo sapiens_hsa009101.21073185
32Viral myocarditis_Homo sapiens_hsa054161.18527340
33African trypanosomiasis_Homo sapiens_hsa051431.13779121
34Toxoplasmosis_Homo sapiens_hsa051451.12715702
35Other glycan degradation_Homo sapiens_hsa005111.11914595
36Amoebiasis_Homo sapiens_hsa051461.11250931
37Fat digestion and absorption_Homo sapiens_hsa049751.07993710
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07259864
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06171847
40Tight junction_Homo sapiens_hsa045301.05135630
41VEGF signaling pathway_Homo sapiens_hsa043701.04368560
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.02454307
43Proteoglycans in cancer_Homo sapiens_hsa052051.02250625
44Malaria_Homo sapiens_hsa051441.02025099
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.00974937
46PI3K-Akt signaling pathway_Homo sapiens_hsa041510.99847034
47Rheumatoid arthritis_Homo sapiens_hsa053230.99306374
48Protein digestion and absorption_Homo sapiens_hsa049740.98384082
49Endocytosis_Homo sapiens_hsa041440.95367969
50Salmonella infection_Homo sapiens_hsa051320.92796224
51Platelet activation_Homo sapiens_hsa046110.91844106
52HIF-1 signaling pathway_Homo sapiens_hsa040660.87812090
53* Notch signaling pathway_Homo sapiens_hsa043300.86966110
54ABC transporters_Homo sapiens_hsa020100.85952290
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85306768
56TNF signaling pathway_Homo sapiens_hsa046680.82919771
57MAPK signaling pathway_Homo sapiens_hsa040100.81590839
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.80505050
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77898050
60Bladder cancer_Homo sapiens_hsa052190.77791841
61Ovarian steroidogenesis_Homo sapiens_hsa049130.77602481
62GnRH signaling pathway_Homo sapiens_hsa049120.77546618
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75500576
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74630945
65Renal cell carcinoma_Homo sapiens_hsa052110.74515938
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73936005
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73923379
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72966382
69Pathways in cancer_Homo sapiens_hsa052000.71259074
70Lysine degradation_Homo sapiens_hsa003100.69578822
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69088291
72Starch and sucrose metabolism_Homo sapiens_hsa005000.68788839
73TGF-beta signaling pathway_Homo sapiens_hsa043500.68601041
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68223571
75Renin secretion_Homo sapiens_hsa049240.67639615
76Butanoate metabolism_Homo sapiens_hsa006500.67029475
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67020436
78Phenylalanine metabolism_Homo sapiens_hsa003600.66777597
79Cardiac muscle contraction_Homo sapiens_hsa042600.66512868
80Hepatitis C_Homo sapiens_hsa051600.66488521
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65240990
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62907157
83Ras signaling pathway_Homo sapiens_hsa040140.61841739
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61295060
85Axon guidance_Homo sapiens_hsa043600.60199804
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59839997
87Arginine and proline metabolism_Homo sapiens_hsa003300.58455781
88Renin-angiotensin system_Homo sapiens_hsa046140.58416753
89AMPK signaling pathway_Homo sapiens_hsa041520.57937714
90Cocaine addiction_Homo sapiens_hsa050300.56839655
91beta-Alanine metabolism_Homo sapiens_hsa004100.56678922
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56505481
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56235513
94Prolactin signaling pathway_Homo sapiens_hsa049170.55914742
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55830556
96Gap junction_Homo sapiens_hsa045400.55814075
97Estrogen signaling pathway_Homo sapiens_hsa049150.55633141
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55484742
99Osteoclast differentiation_Homo sapiens_hsa043800.54759500
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.52608638
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52549650
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51668092
103Carbon metabolism_Homo sapiens_hsa012000.51172004
104Legionellosis_Homo sapiens_hsa051340.50770588
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50514398
106Choline metabolism in cancer_Homo sapiens_hsa052310.50228925
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.48319149
108Lysosome_Homo sapiens_hsa041420.48223737
109Shigellosis_Homo sapiens_hsa051310.47855011
110Insulin signaling pathway_Homo sapiens_hsa049100.47766520
111Glioma_Homo sapiens_hsa052140.46945770
112FoxO signaling pathway_Homo sapiens_hsa040680.46825979
113Oxytocin signaling pathway_Homo sapiens_hsa049210.45814009
114Acute myeloid leukemia_Homo sapiens_hsa052210.45259374
115Staphylococcus aureus infection_Homo sapiens_hsa051500.44947993
116Type II diabetes mellitus_Homo sapiens_hsa049300.44154363
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44142729
118Pyruvate metabolism_Homo sapiens_hsa006200.44091062
119Melanogenesis_Homo sapiens_hsa049160.43468354
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.43223341
121Leishmaniasis_Homo sapiens_hsa051400.42820917
122MicroRNAs in cancer_Homo sapiens_hsa052060.42220927
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42208077
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42002551
125Vitamin digestion and absorption_Homo sapiens_hsa049770.41639452
126Circadian rhythm_Homo sapiens_hsa047100.41390849
127Influenza A_Homo sapiens_hsa051640.40448203
128Prion diseases_Homo sapiens_hsa050200.39854187
129Insulin secretion_Homo sapiens_hsa049110.39670501
130Prostate cancer_Homo sapiens_hsa052150.39375230
131cAMP signaling pathway_Homo sapiens_hsa040240.39304852
132Pancreatic cancer_Homo sapiens_hsa052120.38641205
133Chronic myeloid leukemia_Homo sapiens_hsa052200.38462195
134Apoptosis_Homo sapiens_hsa042100.38221148
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37906858
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37610542
137Galactose metabolism_Homo sapiens_hsa000520.37055504
138Thyroid cancer_Homo sapiens_hsa052160.36757081
139Glucagon signaling pathway_Homo sapiens_hsa049220.36164969
140Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35782828

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