DLST

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* tricarboxylic acid cycle (GO:0006099)6.15074321
2carnitine shuttle (GO:0006853)5.77972326
3* lysine metabolic process (GO:0006553)5.75212279
4* lysine catabolic process (GO:0006554)5.75212279
5fatty acid transmembrane transport (GO:1902001)5.52555043
62-oxoglutarate metabolic process (GO:0006103)5.31067227
7fatty acid beta-oxidation (GO:0006635)5.10123480
8NADH metabolic process (GO:0006734)4.98456122
9regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.78523491
10tricarboxylic acid metabolic process (GO:0072350)4.73139305
11amino-acid betaine transport (GO:0015838)4.61357515
12carnitine transport (GO:0015879)4.61357515
13carnitine transmembrane transport (GO:1902603)4.57918268
14regulation of fatty acid oxidation (GO:0046320)4.57722312
15regulation of sequestering of triglyceride (GO:0010889)4.54122679
16fatty acid oxidation (GO:0019395)4.50359286
17* aspartate family amino acid catabolic process (GO:0009068)4.45076466
18lipid oxidation (GO:0034440)4.39962566
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.38149191
20glyoxylate metabolic process (GO:0046487)4.37586855
21fatty acid catabolic process (GO:0009062)4.37122772
22oxaloacetate metabolic process (GO:0006107)4.32612793
23alpha-linolenic acid metabolic process (GO:0036109)4.30686325
24positive regulation of fatty acid beta-oxidation (GO:0032000)4.25398089
25regulation of acyl-CoA biosynthetic process (GO:0050812)4.24958015
26valine metabolic process (GO:0006573)4.24395303
27sarcomere organization (GO:0045214)4.22581793
28succinate metabolic process (GO:0006105)4.15174094
29* acetyl-CoA metabolic process (GO:0006084)4.14301158
30short-chain fatty acid metabolic process (GO:0046459)4.09915974
31amino-acid betaine metabolic process (GO:0006577)4.07313137
32cellular ketone body metabolic process (GO:0046950)4.06275248
33positive regulation of fatty acid oxidation (GO:0046321)4.04496872
34cell-substrate adherens junction assembly (GO:0007045)4.03862858
35focal adhesion assembly (GO:0048041)4.03862858
36regulation of fatty acid beta-oxidation (GO:0031998)4.02804838
37regulation of cofactor metabolic process (GO:0051193)4.02394902
38regulation of coenzyme metabolic process (GO:0051196)4.02394902
39carnitine metabolic process (GO:0009437)3.99813720
40biotin metabolic process (GO:0006768)3.96909253
41protein localization to endosome (GO:0036010)3.93770444
42branched-chain amino acid catabolic process (GO:0009083)3.92636166
43cardiac myofibril assembly (GO:0055003)3.92265358
44negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.91253316
45L-phenylalanine metabolic process (GO:0006558)3.90424660
46erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.90424660
47regulation of triglyceride catabolic process (GO:0010896)3.89232369
48quaternary ammonium group transport (GO:0015697)3.89154855
49adherens junction assembly (GO:0034333)3.88122587
50monocarboxylic acid catabolic process (GO:0072329)3.88084679
51branched-chain amino acid metabolic process (GO:0009081)3.86247450
52erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.80854820
53L-phenylalanine catabolic process (GO:0006559)3.80854820
54kynurenine metabolic process (GO:0070189)3.71052829
55cysteine metabolic process (GO:0006534)3.70166201
56cell-substrate junction assembly (GO:0007044)3.69478011
57Golgi transport vesicle coating (GO:0048200)3.59801162
58COPI coating of Golgi vesicle (GO:0048205)3.59801162
59triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.58863804
60ketone body metabolic process (GO:1902224)3.53777054
61negative regulation of potassium ion transmembrane transport (GO:1901380)3.52493738
62dicarboxylic acid biosynthetic process (GO:0043650)3.48006539
63sulfur amino acid catabolic process (GO:0000098)3.40631987
64low-density lipoprotein particle clearance (GO:0034383)3.40243106
65positive regulation of lipid catabolic process (GO:0050996)3.37563474
66plasma membrane repair (GO:0001778)3.36584754
67homocysteine metabolic process (GO:0050667)3.36512907
68regulation of early endosome to late endosome transport (GO:2000641)3.36210222
69fatty acid homeostasis (GO:0055089)3.35449062
70regulation of sulfur metabolic process (GO:0042762)3.34266964
71aromatic amino acid family catabolic process (GO:0009074)3.32457290
72myofibril assembly (GO:0030239)3.32220430
73negative regulation of fatty acid biosynthetic process (GO:0045717)3.31364974
74cardiac muscle contraction (GO:0060048)3.23991970
75ethanol oxidation (GO:0006069)3.23488020
76actin-myosin filament sliding (GO:0033275)3.23252059
77muscle filament sliding (GO:0030049)3.23252059
78phospholipid homeostasis (GO:0055091)3.22704402
79negative regulation of fatty acid transport (GO:2000192)3.18386820
80stress fiber assembly (GO:0043149)3.16278441
81bundle of His cell to Purkinje myocyte communication (GO:0086069)3.14870710
824-hydroxyproline metabolic process (GO:0019471)3.14218291
83regulation of glucose import in response to insulin stimulus (GO:2001273)3.14089729
84barbed-end actin filament capping (GO:0051016)3.13694324
85serine family amino acid catabolic process (GO:0009071)3.12899674
86epithelial cell-cell adhesion (GO:0090136)3.12518659
87* carboxylic acid catabolic process (GO:0046395)3.12034888
88* organic acid catabolic process (GO:0016054)3.12034888
89urea cycle (GO:0000050)3.11447857
90urea metabolic process (GO:0019627)3.11447857
91regulation of NFAT protein import into nucleus (GO:0051532)3.10350235
92cellular modified amino acid catabolic process (GO:0042219)3.08316539
93regulation of fatty acid metabolic process (GO:0019217)3.07365828
94intracellular lipid transport (GO:0032365)3.06748303
95regulation of cholesterol homeostasis (GO:2000188)3.06736128
96negative regulation of fatty acid metabolic process (GO:0045922)3.05860429
97embryonic process involved in female pregnancy (GO:0060136)3.05139097
98* alpha-amino acid catabolic process (GO:1901606)3.04152067
99plasma lipoprotein particle clearance (GO:0034381)3.03666807
100negative regulation of erythrocyte differentiation (GO:0045647)3.01954456
101response to mercury ion (GO:0046689)3.01818902
102pinocytosis (GO:0006907)3.01745988
103mannose metabolic process (GO:0006013)3.00765834
104* cellular amino acid catabolic process (GO:0009063)2.97459456
105positive regulation of triglyceride metabolic process (GO:0090208)2.97205339
106basement membrane organization (GO:0071711)2.95096737
107positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.95083424
108positive regulation of fatty acid metabolic process (GO:0045923)2.94524517
109indole-containing compound catabolic process (GO:0042436)2.93604297
110indolalkylamine catabolic process (GO:0046218)2.93604297
111tryptophan catabolic process (GO:0006569)2.93604297
112bile acid biosynthetic process (GO:0006699)2.92850947
113acylglycerol homeostasis (GO:0055090)2.92248711
114triglyceride homeostasis (GO:0070328)2.92248711
115glutamate metabolic process (GO:0006536)2.92141363
116cardiac muscle cell development (GO:0055013)2.91656677
117negative regulation of cell size (GO:0045792)2.90054098
118thioester biosynthetic process (GO:0035384)2.89709641
119acyl-CoA biosynthetic process (GO:0071616)2.89709641
120skin morphogenesis (GO:0043589)2.88455030
121positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.86803422
122response to laminar fluid shear stress (GO:0034616)2.86625560
123cytoskeletal anchoring at plasma membrane (GO:0007016)2.86520818
124hemidesmosome assembly (GO:0031581)2.83324500
125retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.82391055
1263-UTR-mediated mRNA stabilization (GO:0070935)2.79219994
127positive regulation of Cdc42 GTPase activity (GO:0043089)2.78398225
128activation of Rac GTPase activity (GO:0032863)2.75856489
129apoptotic process involved in morphogenesis (GO:0060561)2.75038761
130positive regulation of blood vessel endothelial cell migration (GO:0043536)2.69948492
131planar cell polarity pathway involved in neural tube closure (GO:0090179)2.58641022
132insulin-like growth factor receptor signaling pathway (GO:0048009)2.57332152
133desmosome organization (GO:0002934)2.56960056
134adhesion of symbiont to host (GO:0044406)2.55725816
135negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.55209674
136hypotonic response (GO:0006971)2.46741496
137positive regulation of extracellular matrix organization (GO:1903055)2.46001498
138activation of MAPKKK activity (GO:0000185)2.41497180
139pentose-phosphate shunt (GO:0006098)2.40504149
140negative regulation of necroptotic process (GO:0060546)2.40420395
141endodermal cell differentiation (GO:0035987)2.39954864
142positive regulation of myotube differentiation (GO:0010831)2.39035979
143maternal placenta development (GO:0001893)2.38623044
144RNA stabilization (GO:0043489)2.38052742
145mRNA stabilization (GO:0048255)2.38052742
146vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.37359602
147embryo implantation (GO:0007566)2.35500311
148adhesion of symbiont to host cell (GO:0044650)2.34642562
149virion attachment to host cell (GO:0019062)2.34642562
150regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.34579268
151modulation by symbiont of host cellular process (GO:0044068)2.34322253
152negative regulation of skeletal muscle tissue development (GO:0048642)2.33701314
153proline biosynthetic process (GO:0006561)2.33341831
154regulation of necroptotic process (GO:0060544)2.32734159
155regulation of extracellular matrix disassembly (GO:0010715)2.32311497
156maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.30332317
157positive regulation of endothelial cell apoptotic process (GO:2000353)2.30268571
158skeletal muscle adaptation (GO:0043501)2.28008080
159intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.27569040
160protein retention in ER lumen (GO:0006621)2.25310454
161regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.25110590
162positive regulation of receptor recycling (GO:0001921)2.24762700
163surfactant homeostasis (GO:0043129)2.23731830
164branching involved in mammary gland duct morphogenesis (GO:0060444)2.23615572
165activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.23543795
166histone H3-K36 demethylation (GO:0070544)2.21570919
167cell adhesion mediated by integrin (GO:0033627)2.19900730
168regulation of membrane protein ectodomain proteolysis (GO:0051043)2.19310349
169apoptotic cell clearance (GO:0043277)2.19194512
170mitotic chromosome condensation (GO:0007076)2.17834139
171glucose 6-phosphate metabolic process (GO:0051156)2.17793399
172sarcoplasmic reticulum calcium ion transport (GO:0070296)2.17654215
173regulation of mammary gland epithelial cell proliferation (GO:0033599)2.15971782
174hyaluronan catabolic process (GO:0030214)2.15872139
175cortical actin cytoskeleton organization (GO:0030866)2.14426280
176positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.14323023
177actin-mediated cell contraction (GO:0070252)2.13595436
178ER-nucleus signaling pathway (GO:0006984)2.13270647
179positive regulation of nuclease activity (GO:0032075)2.13161412
180regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.13119393
181endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.12953372
182regulation of nucleobase-containing compound transport (GO:0032239)2.12889367
183actin filament-based movement (GO:0030048)2.11724666
184cellular response to epidermal growth factor stimulus (GO:0071364)2.11560104
185endoplasmic reticulum unfolded protein response (GO:0030968)2.09793219
186atrioventricular valve morphogenesis (GO:0003181)2.08619797
187negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.08094167
188protein targeting to plasma membrane (GO:0072661)2.08030866
189membrane protein ectodomain proteolysis (GO:0006509)2.07749151
190modulation by virus of host morphology or physiology (GO:0019048)2.07089832

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.15068784
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.61637282
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.23308538
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.92914863
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.36538276
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.17239551
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.09814695
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.08072064
9CLOCK_20551151_ChIP-Seq_293T_Human3.01565024
10* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.79885195
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.63895157
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.46133221
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.30744646
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.30430682
15ZNF263_19887448_ChIP-Seq_K562_Human2.30418917
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.10797469
17TBX20_22328084_ChIP-Seq_HEART_Mouse1.98018490
18TBX20_22080862_ChIP-Seq_HEART_Mouse1.98018490
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.94519243
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84438864
21* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.73613027
22* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.70563494
23KDM2B_26808549_Chip-Seq_K562_Human1.63757149
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61958199
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58149630
26NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.58017669
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57539934
28LXR_22292898_ChIP-Seq_THP-1_Human1.56489986
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.55013687
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48102591
31GATA1_22025678_ChIP-Seq_K562_Human1.47795022
32* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46219691
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46074675
34ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44882929
35ATF3_27146783_Chip-Seq_COLON_Human1.44142562
36VDR_24763502_ChIP-Seq_THP-1_Human1.42342079
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.41346283
38RACK7_27058665_Chip-Seq_MCF-7_Human1.38827899
39* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38424426
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.38127183
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.37965071
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37334984
43* KDM2B_26808549_Chip-Seq_JURKAT_Human1.34894060
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33531150
45* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32513537
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.32078539
47* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31088383
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30586345
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.29795680
50PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.29543242
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27058379
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23580347
53MYC_22102868_ChIP-Seq_BL_Human1.23098695
54UBF1/2_26484160_Chip-Seq_HMECs_Human1.20785728
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20636506
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20496931
57KDM2B_26808549_Chip-Seq_DND41_Human1.18144663
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17543607
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16707976
60SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16530280
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14160512
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.14065202
63* RUNX1_22412390_ChIP-Seq_EML_Mouse1.14063225
64TP53_22127205_ChIP-Seq_IMR90_Human1.13452747
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13244862
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12886461
67* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12752944
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12071449
69SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11085454
70GATA4_21415370_ChIP-Seq_HL-1_Mouse1.10839908
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10346908
72SMC4_20622854_ChIP-Seq_HELA_Human1.09986341
73GATA1_19941826_ChIP-Seq_K562_Human1.09220659
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.08852826
75* HNF4A_19822575_ChIP-Seq_HepG2_Human1.08765638
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08709280
77NCOR1_26117541_ChIP-Seq_K562_Human1.08516758
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08255863
79UTX_26944678_Chip-Seq_JUKART_Human1.08226449
80* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08128336
81* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07644967
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07469886
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07168754
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.06933873
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06882883
86NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.06124314
87MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.05194043
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03606276
89CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03488402
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03336961
91P68_20966046_ChIP-Seq_HELA_Human1.03202904
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02758781
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01734922
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01734922
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01282139
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00823565
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00656681
98P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98835150
99FOXM1_23109430_ChIP-Seq_U2OS_Human0.98185579
100FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97757729
101GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96925372
102FOXO3_23340844_ChIP-Seq_DLD1_Human0.96163223
103TP63_17297297_ChIP-ChIP_HaCaT_Human0.95934453
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95288358
105GATA1_19941827_ChIP-Seq_MEL_Mouse0.94613666
106ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94242952
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94131490
108KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92839357
109* TCF7_22412390_ChIP-Seq_EML_Mouse0.92604192
110CREB1_26743006_Chip-Seq_LNCaP_Human0.92282640
111GATA2_19941826_ChIP-Seq_K562_Human0.89928814
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89865714
113ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88868830
114* GATA6_25053715_ChIP-Seq_YYC3_Human0.88513125
115TRIM28_21343339_ChIP-Seq_HEK293_Human0.87945690
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87455702
117BCOR_27268052_Chip-Seq_Bcells_Human0.85684677
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85260553
119PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85216163
120SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84378977
121EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83915695
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82683812
123BCL6_27268052_Chip-Seq_Bcells_Human0.81373510
124ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81367820
125* GATA4_25053715_ChIP-Seq_YYC3_Human0.81349136
126SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.81111190
127UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.80442476
128KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.78652506
129ESR1_21235772_ChIP-Seq_MCF-7_Human0.78356900
130* VDR_21846776_ChIP-Seq_THP-1_Human0.76647558
131TP63_22573176_ChIP-Seq_HFKS_Human0.76495341
132CTCF_21964334_Chip-Seq_Bcells_Human0.76063903
133MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.75882602
134BRD4_27068464_Chip-Seq_AML-cells_Mouse0.75839582
135TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.75838927
136RUNX1_27514584_Chip-Seq_MCF-7_Human0.74748232
137CTCF_21964334_ChIP-Seq_BJAB-B_Human0.74137906
138STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.73381700
139ELF1_20517297_ChIP-Seq_JURKAT_Human0.72102831
140MAF_26560356_Chip-Seq_TH1_Human0.70025719
141AR_21909140_ChIP-Seq_LNCAP_Human0.69450865
142SPI1_20517297_ChIP-Seq_HL60_Human0.69166042

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.60916781
2MP0002837_dystrophic_cardiac_calcinosis4.54443233
3MP0002139_abnormal_hepatobiliary_system4.09560169
4MP0003646_muscle_fatigue3.62994708
5MP0004084_abnormal_cardiac_muscle3.43563514
6MP0005085_abnormal_gallbladder_physiolo3.26387645
7MP0005365_abnormal_bile_salt3.09231312
8MP0000751_myopathy2.91974468
9MP0004130_abnormal_muscle_cell2.90252638
10MP0003806_abnormal_nucleotide_metabolis2.67477379
11MP0004215_abnormal_myocardial_fiber2.63301567
12MP0005330_cardiomyopathy2.58944551
13MP0003705_abnormal_hypodermis_morpholog2.57761331
14MP0004036_abnormal_muscle_relaxation2.53310801
15MP0005670_abnormal_white_adipose2.42159280
16MP0003252_abnormal_bile_duct2.37072652
17MP0002877_abnormal_melanocyte_morpholog2.32881415
18MP0000749_muscle_degeneration2.32735069
19MP0005666_abnormal_adipose_tissue2.30507353
20MP0010329_abnormal_lipoprotein_level2.27435459
21MP0005076_abnormal_cell_differentiation2.22523963
22MP0005332_abnormal_amino_acid2.20339314
23MP0008875_abnormal_xenobiotic_pharmacok2.17985849
24MP0004087_abnormal_muscle_fiber2.17795879
25MP0005058_abnormal_lysosome_morphology2.12615925
26MP0008775_abnormal_heart_ventricle2.01112957
27MP0003091_abnormal_cell_migration1.99564468
28MP0006036_abnormal_mitochondrial_physio1.98540119
29MP0009840_abnormal_foam_cell1.97685195
30MP0002972_abnormal_cardiac_muscle1.89348203
31MP0001849_ear_inflammation1.82708226
32MP0002269_muscular_atrophy1.82639605
33MP0010630_abnormal_cardiac_muscle1.79626913
34MP0005385_cardiovascular_system_phenoty1.75561669
35MP0001544_abnormal_cardiovascular_syste1.75561669
36MP0005409_darkened_coat_color1.75438604
37MP0000750_abnormal_muscle_regeneration1.75219250
38MP0003453_abnormal_keratinocyte_physiol1.74374168
39MP0005257_abnormal_intraocular_pressure1.73249345
40MP0004185_abnormal_adipocyte_glucose1.72394161
41MP0005620_abnormal_muscle_contractility1.69074182
42MP0003221_abnormal_cardiomyocyte_apopto1.67166171
43MP0006138_congestive_heart_failure1.65287714
44MP0002118_abnormal_lipid_homeostasis1.61347176
45MP0005083_abnormal_biliary_tract1.58169341
46MP0002971_abnormal_brown_adipose1.57624096
47MP0004858_abnormal_nervous_system1.57337944
48MP0003191_abnormal_cellular_cholesterol1.57335283
49MP0000747_muscle_weakness1.56749743
50MP0005319_abnormal_enzyme/_coenzyme1.55169047
51MP0001348_abnormal_lacrimal_gland1.54663403
52MP0005023_abnormal_wound_healing1.53324654
53MP0005375_adipose_tissue_phenotype1.52142978
54MP0003195_calcinosis1.51896544
55MP0001666_abnormal_nutrient_absorption1.51050887
56MP0000609_abnormal_liver_physiology1.50481673
57MP0001958_emphysema1.49983543
58MP0003436_decreased_susceptibility_to1.47067876
59MP0002106_abnormal_muscle_physiology1.44003715
60MP0003303_peritoneal_inflammation1.39388656
61MP0003137_abnormal_impulse_conducting1.38028338
62MP0009643_abnormal_urine_homeostasis1.37138455
63MP0003950_abnormal_plasma_membrane1.36138934
64MP0004947_skin_inflammation1.36106071
65MP0002796_impaired_skin_barrier1.35215073
66MP0004233_abnormal_muscle_weight1.34100546
67MP0004484_altered_response_of1.33294312
68MP0000858_altered_metastatic_potential1.32597769
69MP0005584_abnormal_enzyme/coenzyme_acti1.31287822
70MP0000759_abnormal_skeletal_muscle1.28574866
71MP0008961_abnormal_basal_metabolism1.27516140
72MP0004043_abnormal_pH_regulation1.26886596
73MP0002060_abnormal_skin_morphology1.17292175
74MP0000767_abnormal_smooth_muscle1.15172851
75MP0002254_reproductive_system_inflammat1.14744808
76MP0003566_abnormal_cell_adhesion1.14565105
77MP0008260_abnormal_autophagy1.11232660
78MP0005369_muscle_phenotype1.11162898
79MP0006035_abnormal_mitochondrial_morpho1.10866056
80MP0005623_abnormal_meninges_morphology1.10797212
81MP0002089_abnormal_postnatal_growth/wei1.09798050
82MP0008438_abnormal_cutaneous_collagen1.09758082
83MP0002998_abnormal_bone_remodeling1.08928872
84MP0004264_abnormal_extraembryonic_tissu1.08388965
85MP0002078_abnormal_glucose_homeostasis1.07647628
86MP0002896_abnormal_bone_mineralization1.05484555
87MP0004085_abnormal_heartbeat1.04292575
88MP0001661_extended_life_span1.01569053
89MP0004019_abnormal_vitamin_homeostasis1.00778639
90MP0005501_abnormal_skin_physiology0.97844885
91MP0003941_abnormal_skin_development0.97454424
92MP0005266_abnormal_metabolism0.97402428
93MP0000003_abnormal_adipose_tissue0.96765792
94MP0010368_abnormal_lymphatic_system0.96095246
95MP0005535_abnormal_body_temperature0.95597968
96MP0003656_abnormal_erythrocyte_physiolo0.95239707
97MP0003828_pulmonary_edema0.93638752
98MP0002332_abnormal_exercise_endurance0.93536058
99MP0004145_abnormal_muscle_electrophysio0.92931098
100MP0009278_abnormal_bone_marrow0.87449610
101MP0001756_abnormal_urination0.87240024
102MP0001730_embryonic_growth_arrest0.86992698
103MP0005334_abnormal_fat_pad0.86956193
104MP0002138_abnormal_hepatobiliary_system0.86175608
105MP0000013_abnormal_adipose_tissue0.85619056
106MP0000598_abnormal_liver_morphology0.85422510
107MP0002970_abnormal_white_adipose0.85169278
108MP0002009_preneoplasia0.84920976
109MP0004808_abnormal_hematopoietic_stem0.83109851
110MP0001533_abnormal_skeleton_physiology0.83043291
111MP0005451_abnormal_body_composition0.81770678
112MP0000685_abnormal_immune_system0.81554891
113MP0000266_abnormal_heart_morphology0.80931901
114MP0009115_abnormal_fat_cell0.80849896
115MP0005621_abnormal_cell_physiology0.79189057
116MP0001216_abnormal_epidermal_layer0.79159616
117MP0001915_intracranial_hemorrhage0.78905466
118MP0003300_gastrointestinal_ulcer0.78199612
119MP0000343_altered_response_to0.77844247
120MP0003567_abnormal_fetal_cardiomyocyte0.75454053
121MP0003763_abnormal_thymus_physiology0.74754716
122MP0003448_altered_tumor_morphology0.74412627
123MP0003183_abnormal_peptide_metabolism0.74125015
124MP0009672_abnormal_birth_weight0.73951557
125MP0000467_abnormal_esophagus_morphology0.73142592
126MP0005448_abnormal_energy_balance0.71059770
127MP0000230_abnormal_systemic_arterial0.70504739
128MP0002166_altered_tumor_susceptibility0.70290545
129MP0005503_abnormal_tendon_morphology0.70127790
130MP0010155_abnormal_intestine_physiology0.69412585
131MP0005165_increased_susceptibility_to0.69124907
132MP0010234_abnormal_vibrissa_follicle0.69086808
133MP0003959_abnormal_lean_body0.68271502
134MP0005275_abnormal_skin_tensile0.67230727
135MP0003279_aneurysm0.67001947
136MP0003186_abnormal_redox_activity0.66047792
137MP0004147_increased_porphyrin_level0.65821629
138MP0001614_abnormal_blood_vessel0.64707403
139MP0009931_abnormal_skin_appearance0.63900844
140MP0005636_abnormal_mineral_homeostasis0.63490414
141MP0002128_abnormal_blood_circulation0.62549205
142MP0009642_abnormal_blood_homeostasis0.61848838
143MP0004272_abnormal_basement_membrane0.61383523
144MP0002127_abnormal_cardiovascular_syste0.61317175
145MP0004510_myositis0.60308822
146MP0001765_abnormal_ion_homeostasis0.58737801
147MP0009384_cardiac_valve_regurgitation0.58109881
148MP0000733_abnormal_muscle_development0.55659219
149MP0002136_abnormal_kidney_physiology0.54376942
150MP0010352_gastrointestinal_tract_polyps0.54230634

Predicted human phenotypes

RankGene SetZ-score
1Myoglobinuria (HP:0002913)4.96143571
2Hypoglycemic coma (HP:0001325)4.58191403
3Sudden death (HP:0001699)4.45615643
4Abnormality of fatty-acid metabolism (HP:0004359)4.20742446
5Ketoacidosis (HP:0001993)4.19516779
6Hyperglycinuria (HP:0003108)4.10937035
7Exercise-induced muscle cramps (HP:0003710)4.06681172
8Ketosis (HP:0001946)4.06291039
9Hyperammonemia (HP:0001987)4.01056827
10Rhabdomyolysis (HP:0003201)3.94207970
11Protrusio acetabuli (HP:0003179)3.91325552
12Exercise-induced myalgia (HP:0003738)3.89777021
13Ventricular tachycardia (HP:0004756)3.78585806
14Abnormality of glycine metabolism (HP:0010895)3.58022752
15Abnormality of serine family amino acid metabolism (HP:0010894)3.58022752
16Dicarboxylic aciduria (HP:0003215)3.53847275
17Abnormality of dicarboxylic acid metabolism (HP:0010995)3.53847275
18Right ventricular cardiomyopathy (HP:0011663)3.43757859
19Premature rupture of membranes (HP:0001788)3.30618859
20Xanthomatosis (HP:0000991)3.27551347
21Distal lower limb amyotrophy (HP:0008944)3.22455884
22Muscle fiber splitting (HP:0003555)3.21998543
23Palpitations (HP:0001962)3.19587017
24Hyporeflexia of lower limbs (HP:0002600)3.16946490
25Lipoatrophy (HP:0100578)3.15438881
26Distal lower limb muscle weakness (HP:0009053)3.15351423
27Generalized aminoaciduria (HP:0002909)3.14507139
28Increased connective tissue (HP:0009025)3.13979351
29Deep venous thrombosis (HP:0002625)3.13769011
30Centrally nucleated skeletal muscle fibers (HP:0003687)3.11163989
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.10322393
32Calf muscle hypertrophy (HP:0008981)3.04996679
33Abnormality of glutamine family amino acid metabolism (HP:0010902)3.00980103
34Abnormality of skeletal muscle fiber size (HP:0012084)2.99259741
35Asymmetric septal hypertrophy (HP:0001670)2.98398706
36Hyperacusis (HP:0010780)2.89509374
37Atrial fibrillation (HP:0005110)2.80743183
38Hyperglycinemia (HP:0002154)2.78428773
39Difficulty running (HP:0009046)2.78201834
40Dilated cardiomyopathy (HP:0001644)2.78037907
41Hypoalphalipoproteinemia (HP:0003233)2.77733529
42Intrahepatic cholestasis (HP:0001406)2.74745048
43Conjunctival hamartoma (HP:0100780)2.72971975
44Muscle fiber inclusion bodies (HP:0100299)2.72621745
45Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.72287651
46Muscle hypertrophy of the lower extremities (HP:0008968)2.71736537
47Gout (HP:0001997)2.70081795
48Proximal tubulopathy (HP:0000114)2.68735204
49Abnormality of aromatic amino acid family metabolism (HP:0004338)2.65180339
50Spinal rigidity (HP:0003306)2.63838038
51Abnormality of monocarboxylic acid metabolism (HP:0010996)2.62866493
52Bundle branch block (HP:0011710)2.62379378
53Abnormality of the calf musculature (HP:0001430)2.62298874
54Primary atrial arrhythmia (HP:0001692)2.61952546
55Metabolic acidosis (HP:0001942)2.61891084
56Nemaline bodies (HP:0003798)2.61830590
57Nausea (HP:0002018)2.58075616
58Hepatic necrosis (HP:0002605)2.56971300
59Vertebral compression fractures (HP:0002953)2.56113463
60Mildly elevated creatine phosphokinase (HP:0008180)2.56027425
61Abnormality of the left ventricular outflow tract (HP:0011103)2.53660316
62Subaortic stenosis (HP:0001682)2.53660316
63Flat acetabular roof (HP:0003180)2.53589745
64Atrioventricular block (HP:0001678)2.53388637
65Supraventricular tachycardia (HP:0004755)2.53146786
66Achilles tendon contracture (HP:0001771)2.52450207
67Supraventricular arrhythmia (HP:0005115)2.51900323
68Hypolipoproteinemia (HP:0010981)2.51057135
69Ragged-red muscle fibers (HP:0003200)2.44156930
70Syncope (HP:0001279)2.43794601
71Increased muscle lipid content (HP:0009058)2.42190715
72Ventricular arrhythmia (HP:0004308)2.39185807
73Abnormality of proline metabolism (HP:0010907)2.37794067
74Hydroxyprolinuria (HP:0003080)2.37794067
75Hypobetalipoproteinemia (HP:0003563)2.37047003
76Lymphangioma (HP:0100764)2.36666424
77Abnormality of purine metabolism (HP:0004352)2.36392508
78Cerebral edema (HP:0002181)2.35476518
79EMG: myopathic abnormalities (HP:0003458)2.34756978
80Cerebral aneurysm (HP:0004944)2.33644362
81Abnormality of the Achilles tendon (HP:0005109)2.32000010
82Skin nodule (HP:0200036)2.30948192
83Cervical subluxation (HP:0003308)2.30248597
84Lower limb amyotrophy (HP:0007210)2.29921573
85Hyperlipoproteinemia (HP:0010980)2.29675791
86Heart block (HP:0012722)2.28987857
87Muscle stiffness (HP:0003552)2.28893218
88Myopathic facies (HP:0002058)2.27044859
89Shallow orbits (HP:0000586)2.26534928
90Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.26410985
91Thin bony cortex (HP:0002753)2.24062194
92Vascular tortuosity (HP:0004948)2.24033167
93Cholelithiasis (HP:0001081)2.23911341
94Difficulty climbing stairs (HP:0003551)2.21500668
95Increased purine levels (HP:0004368)2.21406393
96Hyperuricemia (HP:0002149)2.21406393
97Hamartoma of the eye (HP:0010568)2.19943481
98Lethargy (HP:0001254)2.19732245
99Abnormal atrioventricular conduction (HP:0005150)2.17478467
100Hyperinsulinemic hypoglycemia (HP:0000825)2.16233206
101Epidermoid cyst (HP:0200040)2.16146333
102Aortic aneurysm (HP:0004942)2.15382674
103Ankle contracture (HP:0006466)2.15301667
104Arterial tortuosity (HP:0005116)2.15220441
105Late onset (HP:0003584)2.12074007
106Aneurysm (HP:0002617)2.10142684
107Vomiting (HP:0002013)2.08528987
108Abnormality of aspartate family amino acid metabolism (HP:0010899)2.08220783
109Disproportionate tall stature (HP:0001519)2.06846647
110Abnormality of serum amino acid levels (HP:0003112)2.06813143
111Ulnar bowing (HP:0003031)2.06648190
112Broad face (HP:0000283)2.06519327
113Ulnar deviation of the wrist (HP:0003049)2.04713256
114Abnormal gallbladder morphology (HP:0012437)2.03931069
115Round ear (HP:0100830)2.03049285
116Complement deficiency (HP:0004431)2.02748770
117Type 1 muscle fiber predominance (HP:0003803)2.02448691
118Abnormality of sulfur amino acid metabolism (HP:0004339)2.02045938
119Fragile skin (HP:0001030)1.99805048
120Abnormality of nucleobase metabolism (HP:0010932)1.98741150
121Asymmetry of the thorax (HP:0001555)1.98516730
122Esophageal neoplasm (HP:0100751)1.97494434
123Neoplasm of head and neck (HP:0012288)1.97494434
124Myotonia (HP:0002486)1.96770092
125Upper limb amyotrophy (HP:0009129)1.96179580
126Distal upper limb amyotrophy (HP:0007149)1.96179580
127Neoplasm of the adrenal gland (HP:0100631)1.96177924
128Abnormal cartilage morphology (HP:0002763)1.96107696
129Bladder diverticulum (HP:0000015)1.96015531
130Neonatal death (HP:0003811)1.94640624
131Back pain (HP:0003418)1.93998626
132Mitral regurgitation (HP:0001653)1.93421283
133Osteolytic defects of the hand bones (HP:0009699)1.92852491
134Osteolytic defects of the phalanges of the hand (HP:0009771)1.92852491
135Pheochromocytoma (HP:0002666)1.91980689
136Hyperglycemia (HP:0003074)1.91214490
137Wormian bones (HP:0002645)1.90941098
138Increased variability in muscle fiber diameter (HP:0003557)1.89634862
139Multiple enchondromatosis (HP:0005701)1.88321404
140Blue sclerae (HP:0000592)1.87678697
141Syringomyelia (HP:0003396)1.87150853
142Spinal cord lesions (HP:0100561)1.87150853
143Prolonged QT interval (HP:0001657)1.85954185
144Dysmetric saccades (HP:0000641)1.85143039
145Atrophic scars (HP:0001075)1.84927641
146Hypoglycemic seizures (HP:0002173)1.84183463
147Hemorrhage of the eye (HP:0011885)1.80675255
148Abnormality of the thoracic spine (HP:0100711)1.79117238
149Dilatation of the ascending aorta (HP:0005111)1.77119702
150Short nail (HP:0001799)1.76673251
151Aortic dissection (HP:0002647)1.73644106
152Slender build (HP:0001533)1.72583059
153Insomnia (HP:0100785)1.72355789
154Generalized amyotrophy (HP:0003700)1.72320047
155Neck muscle weakness (HP:0000467)1.72209530
156Cerebral inclusion bodies (HP:0100314)1.71732822
157Obstructive sleep apnea (HP:0002870)1.70684279
158Broad metatarsal (HP:0001783)1.69444079
159Persistence of primary teeth (HP:0006335)1.69183207
160Myocardial infarction (HP:0001658)1.68371914
161Scapular winging (HP:0003691)1.68144434
162Long palpebral fissure (HP:0000637)1.67031026
163Elbow flexion contracture (HP:0002987)1.66454525
164Abnormality of the calcaneus (HP:0008364)1.65911939
165Emphysema (HP:0002097)1.65300245
166Mitral valve prolapse (HP:0001634)1.65112497
167Genu recurvatum (HP:0002816)1.64087847
168Gastrointestinal stroma tumor (HP:0100723)1.64069083
169Hypercortisolism (HP:0001578)1.61546454
170Foot dorsiflexor weakness (HP:0009027)1.61501092
171Advanced eruption of teeth (HP:0006288)1.61287041
172Progressive muscle weakness (HP:0003323)1.59097783
173Coxa vara (HP:0002812)1.58333199
174Hyperparathyroidism (HP:0000843)1.56717933
175Abnormality of complement system (HP:0005339)1.56631158
176Abnormal ossification of hand bones (HP:0005921)1.55273243
177Bulbar palsy (HP:0001283)1.55034046
178Segmental peripheral demyelination/remyelination (HP:0003481)1.54817192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.03401909
2PKN24.46080412
3BCKDK4.32055451
4TTN4.10463314
5PDK33.52522620
6PDK43.52522620
7PRPF4B3.21762187
8SMG13.14665324
9NEK12.86635851
10CDK122.77599377
11LMTK22.59665601
12ERN12.35927356
13SIK12.15627044
14IRAK32.14650535
15OBSCN2.07344290
16PDK21.93336665
17PHKG11.92636970
18PHKG21.92636970
19MAP3K131.92502424
20RIPK11.89297449
21FLT31.61667876
22EEF2K1.61542519
23MYLK1.55922271
24MAP3K101.54397103
25PTK61.44042051
26FGFR41.43880114
27EPHA21.42387554
28MAP2K31.38827165
29DMPK1.38777548
30MAP3K141.29232429
31PDGFRA1.28497152
32CAMK1D1.21049857
33TAOK21.19550272
34WNK41.15675808
35MAP3K71.12861862
36MOS1.02316043
37MAPKAPK30.99554442
38LRRK20.99281773
39PRKAA20.96904648
40ILK0.95205533
41TIE10.93704205
42PINK10.90035113
43PIK3CA0.89845217
44DDR20.89325903
45PRKAA10.89208046
46LATS10.88478222
47PAK30.88304460
48MAP3K90.87427770
49ARAF0.86290364
50MAPK110.84664732
51KSR20.81197650
52NME20.80616694
53RPS6KB20.80324801
54KDR0.78415067
55MAP3K10.78240230
56RPS6KA20.77432070
57ZAP700.77168761
58SCYL20.75034707
59MAP3K30.74979270
60RET0.73659972
61MTOR0.72417725
62LATS20.72091057
63PRKD10.71766585
64FGFR30.71749405
65MST1R0.71616198
66NEK90.71213913
67INSRR0.70635185
68MARK20.70332813
69MELK0.70140313
70NTRK10.68632322
71PRKD20.68608733
72STK240.68582006
73CAMK1G0.68205159
74MAPK120.67912519
75MAP2K20.67833078
76TYRO30.67200114
77ICK0.66825462
78RPS6KC10.64569939
79RPS6KL10.64569939
80MAP3K50.64063631
81MAP2K40.63846078
82STK38L0.63724940
83PDPK10.62957585
84TAOK10.62442163
85PRKD30.61470908
86MAP3K60.61302443
87PDGFRB0.61063553
88PTK20.60134194
89TYK20.59844163
90TGFBR20.58565941
91TESK10.56046562
92PDK10.55962749
93PRKCH0.55884888
94EPHB10.55582762
95JAK30.55266614
96MAP4K10.55079036
97MAP2K10.53933593
98JAK20.53915535
99ROCK10.52961522
100BMX0.52466805
101TBK10.51395591
102STK380.50894075
103MAP3K110.48217053
104CDK40.48180801
105PRKACG0.46592313
106BRAF0.46561877
107IRAK40.46419724
108RPS6KA60.46388121
109JAK10.45696558
110PAK40.45295935
111ABL20.45124846
112CDK90.44861711
113DYRK1B0.44500911
114EPHB20.44310109
115AKT20.43911962
116MAPK70.43556470
117EPHA30.43011878
118FGFR10.42705661
119CDK60.42602879
120BRD40.42113240
121CDK70.40980834
122TESK20.40801720
123SGK30.40344105
124STK100.39967934
125DAPK30.39352868
126PAK20.38789786
127ERBB40.38669436
128HIPK20.38661651
129RIPK40.38656670
130MET0.38294634
131PRKG20.37600318
132CDC42BPA0.37266035
133MAP3K80.35771517
134PTK2B0.34567553
135CAMKK10.34377115
136MAP2K60.32627225
137FER0.32606753
138WNK30.31024861
139GSK3A0.30083098
140CAMK40.29918651
141TRPM70.29780549
142STK40.28799511
143RPS6KA10.28683173

Predicted pathways (KEGG)

RankGene SetZ-score
1* Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.61001095
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.06000977
3Propanoate metabolism_Homo sapiens_hsa006403.59617941
4Fatty acid degradation_Homo sapiens_hsa000713.59363658
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.51117158
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.23589941
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.99666021
8Fatty acid metabolism_Homo sapiens_hsa012122.84723013
9* Carbon metabolism_Homo sapiens_hsa012002.53840225
10Pyruvate metabolism_Homo sapiens_hsa006202.40998398
11Butanoate metabolism_Homo sapiens_hsa006502.36473555
12Nitrogen metabolism_Homo sapiens_hsa009102.31892668
13Arginine biosynthesis_Homo sapiens_hsa002202.23721422
14PPAR signaling pathway_Homo sapiens_hsa033202.21899775
15Tryptophan metabolism_Homo sapiens_hsa003802.18473580
16Primary bile acid biosynthesis_Homo sapiens_hsa001202.16957856
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.00570955
18Other glycan degradation_Homo sapiens_hsa005111.93013123
19Chronic myeloid leukemia_Homo sapiens_hsa052201.90181105
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.72541902
21Biosynthesis of amino acids_Homo sapiens_hsa012301.71710844
22Acute myeloid leukemia_Homo sapiens_hsa052211.68542095
23Peroxisome_Homo sapiens_hsa041461.58654963
24beta-Alanine metabolism_Homo sapiens_hsa004101.58503850
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.54100527
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.54085838
27Prion diseases_Homo sapiens_hsa050201.53755774
28VEGF signaling pathway_Homo sapiens_hsa043701.50717360
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47560180
30Starch and sucrose metabolism_Homo sapiens_hsa005001.45623959
31Non-small cell lung cancer_Homo sapiens_hsa052231.44793223
32B cell receptor signaling pathway_Homo sapiens_hsa046621.43446647
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42024002
34Pancreatic cancer_Homo sapiens_hsa052121.40081418
35Renal cell carcinoma_Homo sapiens_hsa052111.39085032
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38030546
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31190016
38Thyroid cancer_Homo sapiens_hsa052161.30614496
39Fat digestion and absorption_Homo sapiens_hsa049751.25544234
40Endometrial cancer_Homo sapiens_hsa052131.25192026
41Small cell lung cancer_Homo sapiens_hsa052221.24875256
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24252907
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22168723
44Bile secretion_Homo sapiens_hsa049761.21882160
45Fatty acid elongation_Homo sapiens_hsa000621.21455631
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.19152400
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16612788
48Notch signaling pathway_Homo sapiens_hsa043301.14525937
49Adherens junction_Homo sapiens_hsa045201.14475460
50Selenocompound metabolism_Homo sapiens_hsa004501.12706571
51Fatty acid biosynthesis_Homo sapiens_hsa000611.09376237
52Leukocyte transendothelial migration_Homo sapiens_hsa046701.07935908
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07582944
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07526011
55ECM-receptor interaction_Homo sapiens_hsa045121.06579793
56Glycosaminoglycan degradation_Homo sapiens_hsa005311.06399102
57Cardiac muscle contraction_Homo sapiens_hsa042601.04705755
58Phenylalanine metabolism_Homo sapiens_hsa003601.04356918
59* Lysine degradation_Homo sapiens_hsa003101.04296360
60Caffeine metabolism_Homo sapiens_hsa002321.03048922
61GnRH signaling pathway_Homo sapiens_hsa049121.01942237
62Dilated cardiomyopathy_Homo sapiens_hsa054141.01512795
63Hepatitis C_Homo sapiens_hsa051601.01082402
64Complement and coagulation cascades_Homo sapiens_hsa046101.00724241
65Prostate cancer_Homo sapiens_hsa052151.00606939
66TNF signaling pathway_Homo sapiens_hsa046681.00387233
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98802171
68Osteoclast differentiation_Homo sapiens_hsa043800.98673574
69Toxoplasmosis_Homo sapiens_hsa051450.97637840
70Insulin resistance_Homo sapiens_hsa049310.96297786
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95985405
72Glioma_Homo sapiens_hsa052140.95463820
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.95145769
74Hepatitis B_Homo sapiens_hsa051610.93891966
75ErbB signaling pathway_Homo sapiens_hsa040120.93840742
76MicroRNAs in cancer_Homo sapiens_hsa052060.93058159
77Apoptosis_Homo sapiens_hsa042100.92486671
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.92081218
79Prolactin signaling pathway_Homo sapiens_hsa049170.90399680
80Glycerolipid metabolism_Homo sapiens_hsa005610.86906859
81Influenza A_Homo sapiens_hsa051640.85329535
82Glucagon signaling pathway_Homo sapiens_hsa049220.81820039
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.81670494
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80831415
85Arginine and proline metabolism_Homo sapiens_hsa003300.80356905
86Estrogen signaling pathway_Homo sapiens_hsa049150.79183594
87Pentose phosphate pathway_Homo sapiens_hsa000300.78651346
88Sulfur metabolism_Homo sapiens_hsa009200.76313765
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.76299460
90AMPK signaling pathway_Homo sapiens_hsa041520.74499252
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74126841
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73805891
93Galactose metabolism_Homo sapiens_hsa000520.72448490
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72152642
95Inositol phosphate metabolism_Homo sapiens_hsa005620.71116564
96Tyrosine metabolism_Homo sapiens_hsa003500.70220228
97Choline metabolism in cancer_Homo sapiens_hsa052310.70022325
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.69452726
99Insulin signaling pathway_Homo sapiens_hsa049100.68632393
100Viral carcinogenesis_Homo sapiens_hsa052030.68151951
101Lysosome_Homo sapiens_hsa041420.67981362
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67837857
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67563259
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.67271004
105Shigellosis_Homo sapiens_hsa051310.67169279
106T cell receptor signaling pathway_Homo sapiens_hsa046600.66774249
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66487750
108FoxO signaling pathway_Homo sapiens_hsa040680.66216592
109HTLV-I infection_Homo sapiens_hsa051660.65397350
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65161171
111Leishmaniasis_Homo sapiens_hsa051400.64596711
112Fructose and mannose metabolism_Homo sapiens_hsa000510.64443097
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.61957473
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.61751513
115Colorectal cancer_Homo sapiens_hsa052100.60765109
116Histidine metabolism_Homo sapiens_hsa003400.60338951
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60270273
118Parkinsons disease_Homo sapiens_hsa050120.59566735
119ABC transporters_Homo sapiens_hsa020100.57232727
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56905458
121Chemical carcinogenesis_Homo sapiens_hsa052040.56263267
122Endocytosis_Homo sapiens_hsa041440.54368135
123Platelet activation_Homo sapiens_hsa046110.54064219
124Pathways in cancer_Homo sapiens_hsa052000.51155651
125Measles_Homo sapiens_hsa051620.51028905
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49620102
127Sulfur relay system_Homo sapiens_hsa041220.48531276
128Tight junction_Homo sapiens_hsa045300.47948536
129MAPK signaling pathway_Homo sapiens_hsa040100.47747275
130Staphylococcus aureus infection_Homo sapiens_hsa051500.47186498
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45568332
132Salmonella infection_Homo sapiens_hsa051320.45145083
133Oxidative phosphorylation_Homo sapiens_hsa001900.40621954
134Viral myocarditis_Homo sapiens_hsa054160.40596077
135Retinol metabolism_Homo sapiens_hsa008300.39387312
136Glutathione metabolism_Homo sapiens_hsa004800.38463532
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38280320
138Vitamin digestion and absorption_Homo sapiens_hsa049770.37929216
139Folate biosynthesis_Homo sapiens_hsa007900.37247206
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35580354
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34752365
142Alzheimers disease_Homo sapiens_hsa050100.32099634
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31767875
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.30712346
145* Metabolic pathways_Homo sapiens_hsa011000.30578506
146Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27360910
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27185614
148HIF-1 signaling pathway_Homo sapiens_hsa040660.23529888
149Type II diabetes mellitus_Homo sapiens_hsa049300.22845331
150mTOR signaling pathway_Homo sapiens_hsa041500.21645043
151Maturity onset diabetes of the young_Homo sapiens_hsa049500.20936502
152Focal adhesion_Homo sapiens_hsa045100.20176233
153Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.15912125
154One carbon pool by folate_Homo sapiens_hsa006700.13100812
155Huntingtons disease_Homo sapiens_hsa050160.12736130
156Protein digestion and absorption_Homo sapiens_hsa049740.12242065
157Renin-angiotensin system_Homo sapiens_hsa046140.11580567
158Amoebiasis_Homo sapiens_hsa051460.09726945
159cGMP-PKG signaling pathway_Homo sapiens_hsa040220.09431587
160Bladder cancer_Homo sapiens_hsa052190.07281558
161Thyroid hormone signaling pathway_Homo sapiens_hsa049190.06339205
162Proteoglycans in cancer_Homo sapiens_hsa052050.03105310

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