DLX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of chemokine-mediated signaling pathway (GO:0070099)9.13185848
2* negative regulation of oligodendrocyte differentiation (GO:0048715)6.43923836
3neuron recognition (GO:0008038)6.11474512
4pyrimidine nucleobase catabolic process (GO:0006208)5.74249987
5regulation of mammary gland epithelial cell proliferation (GO:0033599)5.72622012
6DNA unwinding involved in DNA replication (GO:0006268)5.59916867
7substrate-independent telencephalic tangential migration (GO:0021826)5.54407668
8substrate-independent telencephalic tangential interneuron migration (GO:0021843)5.54407668
9cell-cell junction maintenance (GO:0045217)5.25602982
10negative chemotaxis (GO:0050919)5.24383808
11response to pheromone (GO:0019236)5.12207931
12cell proliferation in forebrain (GO:0021846)5.09676491
13cell migration involved in sprouting angiogenesis (GO:0002042)5.00075789
14gamma-aminobutyric acid transport (GO:0015812)4.94561995
15cell junction maintenance (GO:0034331)4.83475437
16positive regulation of mitochondrial fission (GO:0090141)4.49278243
17establishment of mitochondrion localization (GO:0051654)4.47850915
18cell migration in hindbrain (GO:0021535)4.38034163
19nucleobase catabolic process (GO:0046113)4.35704488
20regulation of development, heterochronic (GO:0040034)4.28557889
21ganglion development (GO:0061548)4.14840200
22peptidyl-arginine omega-N-methylation (GO:0035247)4.12069364
23deoxyribonucleotide biosynthetic process (GO:0009263)4.07088164
24forebrain neuron differentiation (GO:0021879)4.06915614
25chaperone-mediated protein transport (GO:0072321)4.00640708
26central nervous system projection neuron axonogenesis (GO:0021952)3.98835885
27sympathetic nervous system development (GO:0048485)3.93343885
28positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.92752020
29ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.87630699
30axonal fasciculation (GO:0007413)3.85732306
31nonmotile primary cilium assembly (GO:0035058)3.84280152
32DNA damage response, detection of DNA damage (GO:0042769)3.80596939
33* hippocampus development (GO:0021766)3.79997837
34* neuron fate commitment (GO:0048663)3.79023387
35layer formation in cerebral cortex (GO:0021819)3.78173796
36neuron cell-cell adhesion (GO:0007158)3.74530015
37* negative regulation of Notch signaling pathway (GO:0045746)3.64311429
38* proximal/distal pattern formation (GO:0009954)3.63617768
39cardiac ventricle formation (GO:0003211)3.61790386
40negative regulation of chemotaxis (GO:0050922)3.61309365
41neuron fate specification (GO:0048665)3.60366066
42peptidyl-arginine methylation (GO:0018216)3.56327453
43peptidyl-arginine N-methylation (GO:0035246)3.56327453
44lung secretory cell differentiation (GO:0061140)3.56120626
45* regulation of transcription involved in cell fate commitment (GO:0060850)3.56050670
46* regulation of oligodendrocyte differentiation (GO:0048713)3.50712133
47vocalization behavior (GO:0071625)3.50399209
48postsynaptic membrane organization (GO:0001941)3.47842482
49growth hormone secretion (GO:0030252)3.44392055
50barbed-end actin filament capping (GO:0051016)3.43780866
51DNA strand elongation involved in DNA replication (GO:0006271)3.43293666
52DNA replication initiation (GO:0006270)3.41265695
53cerebellar granule cell differentiation (GO:0021707)3.39924672
54positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.37701433
55negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.36640746
56negative regulation of translation, ncRNA-mediated (GO:0040033)3.36640746
57regulation of translation, ncRNA-mediated (GO:0045974)3.36640746
58negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.36379961
59* negative regulation of glial cell differentiation (GO:0045686)3.36372445
60cardiac chamber formation (GO:0003207)3.30503935
61cerebral cortex radially oriented cell migration (GO:0021799)3.26813688
62protein insertion into membrane (GO:0051205)3.26454732
63DNA strand elongation (GO:0022616)3.25147505
64synapse assembly (GO:0007416)3.25062715
65glial cell proliferation (GO:0014009)3.23864959
66regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.21875730
67spinal cord association neuron differentiation (GO:0021527)3.20020036
68RNA localization (GO:0006403)3.17147802
69histone arginine methylation (GO:0034969)3.16669477
70outer ear morphogenesis (GO:0042473)3.14593042
71glycosphingolipid biosynthetic process (GO:0006688)3.12524499
72positive regulation of axonogenesis (GO:0050772)3.11735680
73cullin deneddylation (GO:0010388)3.11725313
74metallo-sulfur cluster assembly (GO:0031163)3.09691323
75iron-sulfur cluster assembly (GO:0016226)3.09691323
76regulation of timing of cell differentiation (GO:0048505)3.09521231
77epithelial cell fate commitment (GO:0072148)3.08833864
78regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.08772248
79limb bud formation (GO:0060174)3.07752885
80sequestering of actin monomers (GO:0042989)3.07315322
81cerebral cortex cell migration (GO:0021795)3.07097892
82protein-cofactor linkage (GO:0018065)3.06434278
83regulation of mitochondrial fission (GO:0090140)3.05970378
84cerebral cortex neuron differentiation (GO:0021895)3.05376647
85spinal cord development (GO:0021510)3.05297530
86regulation of NFAT protein import into nucleus (GO:0051532)3.04268052
87dosage compensation (GO:0007549)3.04003860
88blood vessel endothelial cell migration (GO:0043534)3.02729571
89head development (GO:0060322)3.02472477
90translesion synthesis (GO:0019985)3.01866094
91cerebellar Purkinje cell layer development (GO:0021680)2.99876087
92positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.97739229
93positive regulation of cell cycle G2/M phase transition (GO:1902751)2.97739229
94regulation of synapse structural plasticity (GO:0051823)2.95703253
95central nervous system neuron axonogenesis (GO:0021955)2.93708075
96negative regulation of microtubule polymerization (GO:0031115)2.93418226
97neural tube formation (GO:0001841)2.92402240
98protein deneddylation (GO:0000338)2.91721608
99astrocyte differentiation (GO:0048708)2.91192628
100positive regulation of dendritic spine development (GO:0060999)2.90994053
101startle response (GO:0001964)2.89834034
102histone H2A acetylation (GO:0043968)2.89342723
103synaptic vesicle exocytosis (GO:0016079)2.86249922
104negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.86072322
105regulation of mRNA splicing, via spliceosome (GO:0048024)2.85784004
106establishment of tissue polarity (GO:0007164)2.85710738
107establishment of planar polarity (GO:0001736)2.85710738
108regulation of short-term neuronal synaptic plasticity (GO:0048172)2.84852366
109negative regulation of synaptic transmission, GABAergic (GO:0032229)2.84439109
110ubiquinone metabolic process (GO:0006743)2.83804208
111positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.83537695
112mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.83537695
113negative regulation of RNA splicing (GO:0033119)2.81779495
114DNA double-strand break processing (GO:0000729)2.79514189
115regulation of synaptic vesicle exocytosis (GO:2000300)2.76660042
116neuroblast proliferation (GO:0007405)2.76000063
117positive regulation of synapse assembly (GO:0051965)2.74508146
118cell differentiation in spinal cord (GO:0021515)2.73928480
119dendritic spine morphogenesis (GO:0060997)2.73114488
120* negative regulation of gliogenesis (GO:0014014)2.72351098
121regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.71031781
122regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.70408987
123presynaptic membrane assembly (GO:0097105)2.70244802
124regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.69974881
125cellular component maintenance (GO:0043954)2.68649140
126negative regulation of mRNA processing (GO:0050686)2.68278427
127de novo posttranslational protein folding (GO:0051084)2.67525939
128protein heterotetramerization (GO:0051290)2.67280670
129protein localization to synapse (GO:0035418)2.66576269
130kinetochore assembly (GO:0051382)2.64908508
131tooth mineralization (GO:0034505)2.63438355
132establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.62566010
133mitochondrion transport along microtubule (GO:0047497)2.62566010
134L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.62276267
135lymph vessel development (GO:0001945)2.62003990
136reflex (GO:0060004)2.61798832
137neurotransmitter secretion (GO:0007269)2.61014971
138telomere maintenance via semi-conservative replication (GO:0032201)2.60683853
139negative regulation of potassium ion transmembrane transport (GO:1901380)2.60398807
140neuron migration (GO:0001764)2.58090503
141negative regulation of protein localization to cell surface (GO:2000009)2.57847192
142cornea development in camera-type eye (GO:0061303)2.57272750
143resolution of meiotic recombination intermediates (GO:0000712)2.56496591
144ionotropic glutamate receptor signaling pathway (GO:0035235)2.54215601
145nuclear envelope reassembly (GO:0031468)2.53812337
146mitotic nuclear envelope reassembly (GO:0007084)2.53812337
147calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.53724138
148negative regulation of organelle assembly (GO:1902116)2.53709038
149glycine transport (GO:0015816)2.52005708
150cranial nerve morphogenesis (GO:0021602)2.51929147
151synaptic vesicle maturation (GO:0016188)2.51895126
152pyrimidine dimer repair (GO:0006290)2.51636518
153positive regulation of synapse maturation (GO:0090129)2.49941440
154regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.49226644
155DNA integration (GO:0015074)2.46531990
156nucleosome disassembly (GO:0006337)2.45428908
157protein-DNA complex disassembly (GO:0032986)2.45428908
158regulation of respiratory system process (GO:0044065)2.45148020
159base-excision repair, AP site formation (GO:0006285)2.42315359
160positive regulation of RNA splicing (GO:0033120)2.41323483
161de novo protein folding (GO:0006458)2.40523472
162protein polyglutamylation (GO:0018095)2.39307303
163dicarboxylic acid catabolic process (GO:0043649)2.39016181
164germ cell migration (GO:0008354)2.37501347

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.03623919
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.00127524
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.27910545
4ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.22695698
5TP63_19390658_ChIP-ChIP_HaCaT_Human2.74979264
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.72176367
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69018947
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.57963206
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.57690596
10THAP11_20581084_ChIP-Seq_MESCs_Mouse2.52550943
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50424873
12* EZH2_27304074_Chip-Seq_ESCs_Mouse2.49405083
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.46467044
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.44232448
15IGF1R_20145208_ChIP-Seq_DFB_Human2.42193742
16* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.41767613
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.27518931
18GABP_19822575_ChIP-Seq_HepG2_Human2.27397537
19ZFP281_18757296_ChIP-ChIP_E14_Mouse2.22465247
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16256560
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11939056
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11105890
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.08071996
24* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.05302579
25* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.05302579
26E2F7_22180533_ChIP-Seq_HELA_Human10.9592863
27* CBX2_27304074_Chip-Seq_ESCs_Mouse1.97451371
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96923600
29* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.94331854
30* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94177667
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.91713292
32* EZH2_27294783_Chip-Seq_ESCs_Mouse1.91124948
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.90679306
34* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.90016417
35* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88444136
36CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.85962300
37* EED_16625203_ChIP-ChIP_MESCs_Mouse1.83837382
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.83271680
39* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.82291114
40CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.81633850
41* TP53_20018659_ChIP-ChIP_R1E_Mouse1.80242249
42* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80037000
43OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.79969553
44DCP1A_22483619_ChIP-Seq_HELA_Human1.78129058
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.76080686
46* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75595732
47* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.74892716
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73741586
49* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73673816
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.73585273
51SOX2_16153702_ChIP-ChIP_HESCs_Human1.73150231
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.71542990
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69009730
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.68118202
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.67062575
56KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.66144112
57TTF2_22483619_ChIP-Seq_HELA_Human1.65673698
58HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.65576527
59VDR_23849224_ChIP-Seq_CD4+_Human1.63847629
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62993511
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.61125340
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58591550
63* RING1B_27294783_Chip-Seq_NPCs_Mouse1.56497713
64MYC_18940864_ChIP-ChIP_HL60_Human1.54808038
65PKCTHETA_26484144_Chip-Seq_BREAST_Human1.54045187
66E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53971935
67GBX2_23144817_ChIP-Seq_PC3_Human1.52545159
68ELK1_19687146_ChIP-ChIP_HELA_Human1.51100128
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.49184834
70RING1B_27294783_Chip-Seq_ESCs_Mouse1.48387371
71* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45558365
72* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45176342
73KDM5A_27292631_Chip-Seq_BREAST_Human1.44342866
74ZFP281_27345836_Chip-Seq_ESCs_Mouse1.43195889
75REST_21632747_ChIP-Seq_MESCs_Mouse1.41595514
76EWS_26573619_Chip-Seq_HEK293_Human1.39055427
77CIITA_25753668_ChIP-Seq_RAJI_Human1.38159101
78RNF2_27304074_Chip-Seq_NSC_Mouse1.37660593
79CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36502814
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36227219
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35358100
82* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30644162
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28850234
84FOXP3_21729870_ChIP-Seq_TREG_Human1.28042314
85TRIM28_21343339_ChIP-Seq_HEK293_Human1.27491956
86MYC_18555785_ChIP-Seq_MESCs_Mouse1.26812033
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.26119100
88RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25808285
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24862394
90* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23486050
91REST_18959480_ChIP-ChIP_MESCs_Mouse1.22799332
92RARB_27405468_Chip-Seq_BRAIN_Mouse1.20900620
93FUS_26573619_Chip-Seq_HEK293_Human1.19546438
94* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19413823
95ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17760007
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16742775
97* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.16236064
98POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16114772
99IRF1_19129219_ChIP-ChIP_H3396_Human1.15856085
100CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15690996
101CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.14262430
102* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14189245
103CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12978392
104* SOX3_22085726_ChIP-Seq_NPCs_Mouse1.12164103
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11441235
106MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11081008
107* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10432372
108DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09485918
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09223090
110NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08776593
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08396023
112PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08146430
113TAF15_26573619_Chip-Seq_HEK293_Human1.07318206
114PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02768523
115KDM2B_26808549_Chip-Seq_K562_Human1.02004111
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01812984
117FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01615322
118IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01334154
119MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99720515
120CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98586139
121E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97460976
122ZNF274_21170338_ChIP-Seq_K562_Hela0.97069705
123SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96993710
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96873754
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96600471
126ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96280686
127ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95748769
128DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94421298
129SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.93880876
130PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93201752
131E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92564366
132DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92184355
133MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91713656
134REST_19997604_ChIP-ChIP_NEURONS_Mouse0.91248942
135* XRN2_22483619_ChIP-Seq_HELA_Human0.90716329
136FOXM1_23109430_ChIP-Seq_U2OS_Human0.89279213
137ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88277309
138SOX9_26525672_Chip-Seq_HEART_Mouse0.86858863
139AR_21909140_ChIP-Seq_LNCAP_Human0.84537004
140POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.84330029
141* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.82857294
142GATA1_26923725_Chip-Seq_HPCs_Mouse0.81389754
143ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.80570662
144NANOG_16153702_ChIP-ChIP_HESCs_Human0.79643762
145* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78130431
146* TP53_23651856_ChIP-Seq_MEFs_Mouse0.77837995
147DROSHA_22980978_ChIP-Seq_HELA_Human0.76687977
148SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75692400
149E2F1_21310950_ChIP-Seq_MCF-7_Human0.75282430
150ELK4_26923725_Chip-Seq_MESODERM_Mouse0.73814621
151SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.72701934
152* KDM2B_26808549_Chip-Seq_JURKAT_Human0.71943403
153MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.71929786
154LXR_22292898_ChIP-Seq_THP-1_Human0.71502166
155MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.70444318
156TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.69401578
157* KDM2B_26808549_Chip-Seq_DND41_Human0.68931569
158SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.68525500

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium4.85358514
2MP0010030_abnormal_orbit_morphology4.36011466
3MP0005499_abnormal_olfactory_system4.08222113
4MP0005394_taste/olfaction_phenotype4.08222113
5MP0005646_abnormal_pituitary_gland3.66878021
6MP0000778_abnormal_nervous_system3.57027704
7MP0002653_abnormal_ependyma_morphology3.35730229
8* MP0000049_abnormal_middle_ear3.10585775
9MP0005645_abnormal_hypothalamus_physiol3.02721657
10MP0005623_abnormal_meninges_morphology2.90537941
11MP0002102_abnormal_ear_morphology2.90317432
12MP0002249_abnormal_larynx_morphology2.71203317
13MP0002822_catalepsy2.64209425
14MP0001188_hyperpigmentation2.62075570
15MP0006292_abnormal_olfactory_placode2.59488649
16MP0005248_abnormal_Harderian_gland2.44532930
17MP0003115_abnormal_respiratory_system2.34684213
18* MP0001270_distended_abdomen2.29992271
19MP0003880_abnormal_central_pattern2.22773791
20MP0001346_abnormal_lacrimal_gland2.21645508
21MP0004859_abnormal_synaptic_plasticity2.12563461
22MP0003122_maternal_imprinting2.08556145
23MP0008995_early_reproductive_senescence2.08421326
24MP0000566_synostosis2.06057154
25MP0005187_abnormal_penis_morphology1.98906277
26MP0004858_abnormal_nervous_system1.83546054
27MP0002277_abnormal_respiratory_mucosa1.79642889
28MP0003938_abnormal_ear_development1.77237293
29* MP0003755_abnormal_palate_morphology1.73812481
30MP0005367_renal/urinary_system_phenotyp1.73371274
31MP0000516_abnormal_urinary_system1.73371274
32MP0000955_abnormal_spinal_cord1.69435402
33* MP0003861_abnormal_nervous_system1.69090210
34MP0002098_abnormal_vibrissa_morphology1.68223989
35MP0002184_abnormal_innervation1.61227633
36MP0002234_abnormal_pharynx_morphology1.59898638
37MP0005076_abnormal_cell_differentiation1.53014109
38* MP0004811_abnormal_neuron_physiology1.52885977
39MP0002177_abnormal_outer_ear1.51756649
40MP0005257_abnormal_intraocular_pressure1.49251674
41MP0003221_abnormal_cardiomyocyte_apopto1.47291399
42MP0002557_abnormal_social/conspecific_i1.41921147
43MP0003693_abnormal_embryo_hatching1.41256241
44MP0003635_abnormal_synaptic_transmissio1.40032320
45MP0001529_abnormal_vocalization1.39212908
46* MP0003935_abnormal_craniofacial_develop1.37649727
47* MP0002116_abnormal_craniofacial_bone1.35624594
48MP0000013_abnormal_adipose_tissue1.35279004
49MP0008058_abnormal_DNA_repair1.34303768
50MP0002233_abnormal_nose_morphology1.32652423
51MP0000631_abnormal_neuroendocrine_gland1.28231077
52* MP0002152_abnormal_brain_morphology1.27233891
53MP0002736_abnormal_nociception_after1.26765675
54MP0000537_abnormal_urethra_morphology1.24203752
55MP0001984_abnormal_olfaction1.23968761
56MP0002064_seizures1.23225085
57MP0003786_premature_aging1.21772793
58MP0003937_abnormal_limbs/digits/tail_de1.21081013
59MP0003121_genomic_imprinting1.20629558
60MP0001968_abnormal_touch/_nociception1.20145327
61* MP0002081_perinatal_lethality1.17328904
62* MP0002882_abnormal_neuron_morphology1.17012833
63MP0004270_analgesia1.15458871
64MP0002063_abnormal_learning/memory/cond1.14651846
65MP0003385_abnormal_body_wall1.14164617
66MP0002734_abnormal_mechanical_nocicepti1.13621835
67MP0001502_abnormal_circadian_rhythm1.13333410
68MP0005253_abnormal_eye_physiology1.12357802
69MP0006072_abnormal_retinal_apoptosis1.12343518
70MP0002282_abnormal_trachea_morphology1.10478101
71MP0000428_abnormal_craniofacial_morphol1.10438739
72MP0004142_abnormal_muscle_tone1.09320819
73MP0005409_darkened_coat_color1.06410318
74MP0002272_abnormal_nervous_system1.05160472
75MP0009250_abnormal_appendicular_skeleto1.04719771
76MP0006276_abnormal_autonomic_nervous1.03789058
77MP0004133_heterotaxia1.03271280
78MP0009379_abnormal_foot_pigmentation1.01847386
79MP0005423_abnormal_somatic_nervous1.01741134
80MP0002697_abnormal_eye_size1.00549880
81MP0009745_abnormal_behavioral_response0.99598727
82* MP0000163_abnormal_cartilage_morphology0.99516273
83MP0001986_abnormal_taste_sensitivity0.98845145
84* MP0001943_abnormal_respiration0.98338841
85MP0001177_atelectasis0.96824023
86MP0002160_abnormal_reproductive_system0.94294988
87MP0002733_abnormal_thermal_nociception0.93457324
88MP0009046_muscle_twitch0.92769764
89MP0002735_abnormal_chemical_nociception0.92420827
90MP0003705_abnormal_hypodermis_morpholog0.92188530
91MP0000762_abnormal_tongue_morphology0.92023067
92MP0003111_abnormal_nucleus_morphology0.91812794
93MP0004924_abnormal_behavior0.90016442
94MP0005386_behavior/neurological_phenoty0.90016442
95* MP0000432_abnormal_head_morphology0.89876156
96MP0003942_abnormal_urinary_system0.89578826
97MP0002638_abnormal_pupillary_reflex0.89342323
98MP0006035_abnormal_mitochondrial_morpho0.87135946
99MP0001905_abnormal_dopamine_level0.86396376
100MP0005391_vision/eye_phenotype0.84776190
101MP0003698_abnormal_male_reproductive0.84105657
102MP0000681_abnormal_thyroid_gland0.83361245
103MP0002751_abnormal_autonomic_nervous0.83211992
104MP0002092_abnormal_eye_morphology0.83126436
105* MP0002069_abnormal_eating/drinking_beha0.81665688
106MP0000678_abnormal_parathyroid_gland0.80725682
107MP0008007_abnormal_cellular_replicative0.80210046
108MP0009053_abnormal_anal_canal0.79018249
109MP0010094_abnormal_chromosome_stability0.78005807
110MP0002572_abnormal_emotion/affect_behav0.75476938
111MP0009384_cardiac_valve_regurgitation0.74709085
112MP0003119_abnormal_digestive_system0.73152502
113MP0001299_abnormal_eye_distance/0.72305961
114MP0004197_abnormal_fetal_growth/weight/0.71659802
115* MP0002752_abnormal_somatic_nervous0.71434473
116MP0003787_abnormal_imprinting0.70247434
117MP0008932_abnormal_embryonic_tissue0.69199383
118MP0001286_abnormal_eye_development0.68186931
119MP0008438_abnormal_cutaneous_collagen0.68138495
120MP0001340_abnormal_eyelid_morphology0.67948964
121MP0002210_abnormal_sex_determination0.66657070
122MP0002111_abnormal_tail_morphology0.66455638
123MP0002089_abnormal_postnatal_growth/wei0.65703654
124MP0000026_abnormal_inner_ear0.63231397
125MP0002082_postnatal_lethality0.62888812
126MP0010770_preweaning_lethality0.62888812
127MP0001486_abnormal_startle_reflex0.61999549
128MP0005197_abnormal_uvea_morphology0.61992577
129MP0000350_abnormal_cell_proliferation0.61264138
130MP0010769_abnormal_survival0.60766262
131MP0001849_ear_inflammation0.58407093
132* MP0002066_abnormal_motor_capabilities/c0.57706316
133MP0001970_abnormal_pain_threshold0.57410084

Predicted human phenotypes

RankGene SetZ-score
1Split foot (HP:0001839)7.16344065
2Large eyes (HP:0001090)5.22761377
3Broad alveolar ridges (HP:0000187)4.57920861
4Megalencephaly (HP:0001355)4.32129322
5Limb dystonia (HP:0002451)4.12995432
6Birth length less than 3rd percentile (HP:0003561)4.08731083
7Shoulder girdle muscle weakness (HP:0003547)3.78880209
8Lissencephaly (HP:0001339)3.70334672
9Retinal dysplasia (HP:0007973)3.38264295
10Pelvic girdle muscle weakness (HP:0003749)3.25910675
11Overlapping toe (HP:0001845)3.25229161
12Trigonocephaly (HP:0000243)3.18837398
13Absent hand (HP:0004050)3.18485228
14Amyotrophic lateral sclerosis (HP:0007354)3.13965986
15Thyroid-stimulating hormone excess (HP:0002925)3.05905854
16Abnormality of the musculature of the pelvis (HP:0001469)3.04703210
17Abnormality of the hip-girdle musculature (HP:0001445)3.04703210
18Double outlet right ventricle (HP:0001719)2.87396583
19Congenital malformation of the right heart (HP:0011723)2.87396583
20Atrophy/Degeneration involving motor neurons (HP:0007373)2.70964128
21Wrist flexion contracture (HP:0001239)2.70664621
22Abnormality of the alveolar ridges (HP:0006477)2.69954587
23Amblyopia (HP:0000646)2.69797306
24Pachygyria (HP:0001302)2.67670861
25Shallow orbits (HP:0000586)2.66572455
26Pendular nystagmus (HP:0012043)2.63846164
27Absent speech (HP:0001344)2.62785566
28Palpebral edema (HP:0100540)2.58996144
29Abnormality of the intervertebral disk (HP:0005108)2.58849299
30Polyphagia (HP:0002591)2.58225316
31Renal dysplasia (HP:0000110)2.58176521
32Hypsarrhythmia (HP:0002521)2.56028036
33Failure to thrive in infancy (HP:0001531)2.51180059
34Optic nerve coloboma (HP:0000588)2.47927482
35Increased number of teeth (HP:0011069)2.47431879
36Occipital encephalocele (HP:0002085)2.46941363
37Abnormality of the metopic suture (HP:0005556)2.42277396
38EEG with generalized epileptiform discharges (HP:0011198)2.41920102
39Hyperventilation (HP:0002883)2.40667381
40Sleep apnea (HP:0010535)2.36610308
41Cortical dysplasia (HP:0002539)2.34254202
42Gait imbalance (HP:0002141)2.33971462
43Exotropia (HP:0000577)2.33538211
44Abnormality of the aortic arch (HP:0012303)2.30087428
45Cerebral hypomyelination (HP:0006808)2.29852681
46Epileptiform EEG discharges (HP:0011182)2.29687271
47Tapered finger (HP:0001182)2.27611070
48Prominent metopic ridge (HP:0005487)2.24876766
49Urinary urgency (HP:0000012)2.24399496
50Nephrogenic diabetes insipidus (HP:0009806)2.22675268
51Ependymoma (HP:0002888)2.21854264
52Spastic tetraplegia (HP:0002510)2.20778086
53Hypomagnesemia (HP:0002917)2.20379311
54Patellar aplasia (HP:0006443)2.18630599
55Hyperacusis (HP:0010780)2.18212220
56Bladder diverticulum (HP:0000015)2.17134515
57Delayed closure of the anterior fontanelle (HP:0001476)2.16313350
58Congenital primary aphakia (HP:0007707)2.14836071
59Turricephaly (HP:0000262)2.13271890
60Septate vagina (HP:0001153)2.12843008
61Type II lissencephaly (HP:0007260)2.10814554
62Abnormality of magnesium homeostasis (HP:0004921)2.08726331
63Neonatal respiratory distress (HP:0002643)2.08150314
64Rimmed vacuoles (HP:0003805)2.07664109
65Medial flaring of the eyebrow (HP:0010747)2.06317379
66Pointed chin (HP:0000307)2.06259321
67Hepatoblastoma (HP:0002884)2.05111277
68Bowel diverticulosis (HP:0005222)2.03864572
69Inability to walk (HP:0002540)2.03019641
70Astrocytoma (HP:0009592)2.02970366
71Abnormality of the astrocytes (HP:0100707)2.02970366
72Aplasia/Hypoplasia of the patella (HP:0006498)2.02612161
73Slender long bone (HP:0003100)2.01782157
74Esotropia (HP:0000565)2.01658246
75Renal duplication (HP:0000075)1.99361095
76Premature rupture of membranes (HP:0001788)1.99069088
77Open mouth (HP:0000194)1.98657280
78Hypoventilation (HP:0002791)1.98626534
79Aplasia/Hypoplasia of the brainstem (HP:0007362)1.98463013
80Hypoplasia of the brainstem (HP:0002365)1.98463013
81Overriding aorta (HP:0002623)1.97859012
82Abnormality of the parathyroid morphology (HP:0011766)1.97573761
83Broad distal phalanx of finger (HP:0009836)1.96600026
84Specific learning disability (HP:0001328)1.96556769
85Progressive microcephaly (HP:0000253)1.95723426
86Spastic gait (HP:0002064)1.94754717
87Aplasia/Hypoplasia of the lens (HP:0008063)1.94082121
88Abnormality of abdominal situs (HP:0011620)1.92725476
89Abdominal situs inversus (HP:0003363)1.92725476
90Epileptic encephalopathy (HP:0200134)1.92456843
91Limb-girdle muscle weakness (HP:0003325)1.91399620
92Abnormality of the labia minora (HP:0012880)1.91244917
93Long clavicles (HP:0000890)1.91080940
94Morphological abnormality of the middle ear (HP:0008609)1.89436494
95Elfin facies (HP:0004428)1.89423211
96High forehead (HP:0000348)1.86798677
97Muscular hypotonia of the trunk (HP:0008936)1.86737213
98Small hand (HP:0200055)1.86572119
99Progressive inability to walk (HP:0002505)1.86537897
100Tetraplegia (HP:0002445)1.86470205
101Coronal craniosynostosis (HP:0004440)1.85345842
102Chronic hepatic failure (HP:0100626)1.84211655
103Polymicrogyria (HP:0002126)1.82963596
104Renovascular hypertension (HP:0100817)1.82936438
105High anterior hairline (HP:0009890)1.82872065
106Dyskinesia (HP:0100660)1.82429586
107CNS hypomyelination (HP:0003429)1.82306539
108Focal dystonia (HP:0004373)1.81831189
109Premature skin wrinkling (HP:0100678)1.81710245
110Malignant neoplasm of the central nervous system (HP:0100836)1.81566015
111Wide anterior fontanel (HP:0000260)1.80928489
112Abnormality of the anterior horn cell (HP:0006802)1.80026649
113Degeneration of anterior horn cells (HP:0002398)1.80026649
114Hypoplasia of the corpus callosum (HP:0002079)1.79324062
115Medulloblastoma (HP:0002885)1.78941530
116Insomnia (HP:0100785)1.78563717
117Ankle clonus (HP:0011448)1.78145484
118Abnormality of the lower motor neuron (HP:0002366)1.77642212
119Intellectual disability, severe (HP:0010864)1.77325547
120Micropenis (HP:0000054)1.76480585
121Limb-girdle muscle atrophy (HP:0003797)1.76018798
122Abnormal number of incisors (HP:0011064)1.74745230
123Slow-growing hair (HP:0002217)1.74643134
124Abnormality of hair growth rate (HP:0011363)1.74643134
125Septo-optic dysplasia (HP:0100842)1.73298375
126Broad-based gait (HP:0002136)1.73249868
127Abnormal mitochondria in muscle tissue (HP:0008316)1.73246873
128Pancreatic cysts (HP:0001737)1.71953994
129Precocious puberty (HP:0000826)1.71906906
130Acute necrotizing encephalopathy (HP:0006965)1.71878473
131Drooling (HP:0002307)1.71303616
132Excessive salivation (HP:0003781)1.71303616
133Abnormal eating behavior (HP:0100738)1.71054263
134Periauricular skin pits (HP:0100277)1.69978845
135Preauricular pit (HP:0004467)1.69978845
136Large for gestational age (HP:0001520)1.69077171
137Microretrognathia (HP:0000308)1.68829266
138Genital tract atresia (HP:0001827)1.68753320
139Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.68106519
140Short 4th metacarpal (HP:0010044)1.68106519
141Periorbital edema (HP:0100539)1.68045879
142Preaxial hand polydactyly (HP:0001177)1.67854794
143Sclerocornea (HP:0000647)1.67822456
144Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67650817
145Abnormality of alanine metabolism (HP:0010916)1.67650817
146Hyperalaninemia (HP:0003348)1.67650817
147Obstructive sleep apnea (HP:0002870)1.67383204
148Severe short stature (HP:0003510)1.67298090
149Chorioretinal atrophy (HP:0000533)1.66187290
150Delayed myelination (HP:0012448)1.66141089
151Aplasia/Hypoplasia of the clavicles (HP:0006710)1.65819738
152Dilatation of the ascending aorta (HP:0005111)1.64879430
153Microglossia (HP:0000171)1.64263813
154Neoplasm of the heart (HP:0100544)1.64026140
155Short philtrum (HP:0000322)1.63173500
156Bicornuate uterus (HP:0000813)1.62893044
157Vaginal atresia (HP:0000148)1.61889767
158Tented upper lip vermilion (HP:0010804)1.61715160
159Protrusio acetabuli (HP:0003179)1.61524476
160Short 1st metacarpal (HP:0010034)1.61306511
161Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.61306511
162Poor coordination (HP:0002370)1.61039885
163Severe global developmental delay (HP:0011344)1.60671466
164Aganglionic megacolon (HP:0002251)1.60472454
165Delusions (HP:0000746)1.59990209
166Unilateral renal agenesis (HP:0000122)1.59823807
167Abnormal connection of the cardiac segments (HP:0011545)1.59506264
168Congenital glaucoma (HP:0001087)1.58619875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.01344341
2MARK13.80781971
3ACVR1B3.50657595
4CDC73.19115885
5DYRK22.97124436
6CSNK1G32.96544508
7CSNK1A1L2.86030192
8MAP4K22.84460710
9ICK2.82509642
10TESK22.79614714
11CSNK1G22.60996902
12ERBB32.49955357
13CCNB12.48783562
14UHMK12.48694298
15CSNK1G12.29976378
16SRPK12.27852878
17LIMK12.24819650
18BMPR1B2.20962925
19TESK11.98495746
20EPHB21.86061107
21MINK11.78854608
22NTRK21.78475281
23LATS21.72689590
24TRIB31.69654049
25MAP2K41.62397119
26MAP3K101.60845004
27BCR1.56355257
28TGFBR11.52415659
29ERBB41.52319717
30BRD41.44308799
31SGK4941.43951473
32SGK2231.43951473
33ROCK11.43325995
34MAP3K41.42694834
35YES11.42602218
36PAK61.39284245
37AKT31.36579141
38RPS6KA41.34846670
39SIK21.32468074
40MKNK11.31925182
41BCKDK1.30692228
42EPHA31.29080601
43KSR11.26146194
44EPHA41.25034497
45PLK41.22642730
46DYRK31.22085182
47MAPK131.18831058
48CDK141.18276093
49PIM21.15642018
50ROCK21.14655170
51IRAK21.12977655
52SIK31.12744769
53ATR1.11027118
54MAP3K91.10646559
55PAK31.07914761
56WEE11.05697274
57ERBB21.05560844
58WNK31.04689137
59PINK11.03304974
60VRK11.03242421
61CDK180.99098838
62PRKD30.98641837
63PRPF4B0.94879072
64CDK150.90019662
65CDK120.87247210
66CDK190.84008938
67STK38L0.83885984
68DMPK0.83302457
69IRAK10.80096710
70CDK11A0.79417828
71RPS6KA10.79128001
72EEF2K0.77473932
73CAMKK20.76818325
74CHEK20.75655807
75DYRK1A0.75451181
76BUB10.74920283
77RPS6KA20.74734107
78CDK70.71155807
79TLK10.70680932
80DDR20.69099972
81BRSK10.67440534
82ADRBK10.66044320
83PLK20.65803727
84CAMK2B0.64437723
85INSRR0.62732231
86PRKCZ0.62635630
87PLK30.62368417
88ERN10.61957955
89MAP2K10.61364039
90DYRK1B0.60978955
91PRKAA10.60417933
92PTK20.59390906
93CASK0.59334431
94MAP3K60.56373631
95RAF10.56308398
96CDK50.56143291
97MAP2K70.56132477
98TAOK10.56049153
99FER0.55872262
100NME10.54179237
101PRKCE0.53540099
102MAP3K50.52917823
103CSNK1A10.52304858
104CAMK40.51702782
105PRKCG0.51637013
106PAK20.50694783
107FRK0.49849619
108SGK20.49099473
109PASK0.48998738
110KSR20.45922198
111AURKA0.43476362
112CDK10.43266553
113TYRO30.42832581
114ZAK0.42629212
115PKN10.42424834
116MAPK90.41682470
117MKNK20.41555121
118CSNK1D0.41248435
119SGK10.41149035
120CHEK10.41083172
121STK160.40813729
122CAMK2A0.40122773
123CDK20.39945278
124CSNK1E0.39943200
125CDK30.38901837
126MAPK110.38687067
127ATM0.37752664
128DAPK20.36817092
129AURKB0.35223963
130MAPKAPK50.34608871
131DAPK10.34422928
132BRSK20.34265917
133RPS6KA50.34183921
134FGFR10.33414316
135CSNK2A10.32651934
136AKT10.32627205
137CAMK2G0.32540753
138PLK10.32420639
139MAPK140.31124429
140PRKDC0.30894632
141MAPK80.30729171
142MAP3K120.29291136
143GSK3B0.28463970
144PRKD10.28337534
145MAPK100.27894881
146FGFR20.27357344

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.71915735
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.45636232
3Axon guidance_Homo sapiens_hsa043603.05468318
4Spliceosome_Homo sapiens_hsa030402.92885772
5Mismatch repair_Homo sapiens_hsa034302.72496654
6Cell cycle_Homo sapiens_hsa041102.49196224
7RNA polymerase_Homo sapiens_hsa030202.33101393
8Sulfur relay system_Homo sapiens_hsa041222.29780796
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13886295
10Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.98620743
11Base excision repair_Homo sapiens_hsa034101.95984770
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.91982564
13Oxidative phosphorylation_Homo sapiens_hsa001901.90240494
14Gap junction_Homo sapiens_hsa045401.89906024
15Basal transcription factors_Homo sapiens_hsa030221.87231160
16Butanoate metabolism_Homo sapiens_hsa006501.86449140
17Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.79862676
18Colorectal cancer_Homo sapiens_hsa052101.73457951
19MicroRNAs in cancer_Homo sapiens_hsa052061.72555625
20RNA transport_Homo sapiens_hsa030131.67890107
21Collecting duct acid secretion_Homo sapiens_hsa049661.67517430
22Parkinsons disease_Homo sapiens_hsa050121.63785819
23Hippo signaling pathway_Homo sapiens_hsa043901.62940633
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.59795833
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52820568
26Basal cell carcinoma_Homo sapiens_hsa052171.52456317
27GABAergic synapse_Homo sapiens_hsa047271.48358662
28p53 signaling pathway_Homo sapiens_hsa041151.47854894
29Notch signaling pathway_Homo sapiens_hsa043301.42996914
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40401781
31Nucleotide excision repair_Homo sapiens_hsa034201.38944156
32Circadian rhythm_Homo sapiens_hsa047101.36729690
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35961748
34Glutamatergic synapse_Homo sapiens_hsa047241.35679202
35Homologous recombination_Homo sapiens_hsa034401.34874855
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33246296
37Huntingtons disease_Homo sapiens_hsa050161.32883256
38Oocyte meiosis_Homo sapiens_hsa041141.31959622
39Wnt signaling pathway_Homo sapiens_hsa043101.31533925
40Hedgehog signaling pathway_Homo sapiens_hsa043401.31323626
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28642795
42Selenocompound metabolism_Homo sapiens_hsa004501.23406661
43Endometrial cancer_Homo sapiens_hsa052131.22943033
44Protein export_Homo sapiens_hsa030601.22787907
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22624226
46Steroid biosynthesis_Homo sapiens_hsa001001.21942065
47Regulation of autophagy_Homo sapiens_hsa041401.21915531
48Nicotine addiction_Homo sapiens_hsa050331.21906770
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.20666562
50Non-homologous end-joining_Homo sapiens_hsa034501.18927561
51Bladder cancer_Homo sapiens_hsa052191.17856480
52Synaptic vesicle cycle_Homo sapiens_hsa047211.15448815
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13412327
54One carbon pool by folate_Homo sapiens_hsa006701.10174365
55Lysine degradation_Homo sapiens_hsa003101.10168055
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08420752
57Alcoholism_Homo sapiens_hsa050341.08006793
58Pyrimidine metabolism_Homo sapiens_hsa002401.07818762
59Dopaminergic synapse_Homo sapiens_hsa047281.07689638
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05638473
61Serotonergic synapse_Homo sapiens_hsa047261.03667855
62RNA degradation_Homo sapiens_hsa030181.00637311
63Cocaine addiction_Homo sapiens_hsa050300.99144075
64mRNA surveillance pathway_Homo sapiens_hsa030150.98835907
65Glioma_Homo sapiens_hsa052140.98223402
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97099805
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96935800
68Phototransduction_Homo sapiens_hsa047440.96895520
69Circadian entrainment_Homo sapiens_hsa047130.96126139
70HTLV-I infection_Homo sapiens_hsa051660.94765697
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93801965
72Morphine addiction_Homo sapiens_hsa050320.90345840
73Melanoma_Homo sapiens_hsa052180.90187183
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89041009
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88743334
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87191122
77Shigellosis_Homo sapiens_hsa051310.82258479
78Melanogenesis_Homo sapiens_hsa049160.81717387
79ErbB signaling pathway_Homo sapiens_hsa040120.80895549
80Non-small cell lung cancer_Homo sapiens_hsa052230.80793008
81GnRH signaling pathway_Homo sapiens_hsa049120.80258050
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79432459
83Cholinergic synapse_Homo sapiens_hsa047250.77770763
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77398917
85Oxytocin signaling pathway_Homo sapiens_hsa049210.77166876
86Alzheimers disease_Homo sapiens_hsa050100.76842985
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76759104
88Proteoglycans in cancer_Homo sapiens_hsa052050.76345025
89Chronic myeloid leukemia_Homo sapiens_hsa052200.75125420
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74115209
91Purine metabolism_Homo sapiens_hsa002300.74025723
92Biosynthesis of amino acids_Homo sapiens_hsa012300.72909130
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72867899
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70681791
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69759678
96Renal cell carcinoma_Homo sapiens_hsa052110.69531192
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69522897
98Pancreatic cancer_Homo sapiens_hsa052120.69179625
99beta-Alanine metabolism_Homo sapiens_hsa004100.67706819
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.64793303
101Tight junction_Homo sapiens_hsa045300.64640216
102Fatty acid biosynthesis_Homo sapiens_hsa000610.64447113
103Dilated cardiomyopathy_Homo sapiens_hsa054140.63439013
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.62860663
105Vibrio cholerae infection_Homo sapiens_hsa051100.62293825
106Focal adhesion_Homo sapiens_hsa045100.61981990
107Long-term depression_Homo sapiens_hsa047300.59889004
108Prion diseases_Homo sapiens_hsa050200.59866256
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.59014960
110Insulin secretion_Homo sapiens_hsa049110.58762378
111Small cell lung cancer_Homo sapiens_hsa052220.58516293
112Proteasome_Homo sapiens_hsa030500.56651611
113Arginine and proline metabolism_Homo sapiens_hsa003300.55210644
114Taste transduction_Homo sapiens_hsa047420.55203045
115FoxO signaling pathway_Homo sapiens_hsa040680.54817345
116Peroxisome_Homo sapiens_hsa041460.53437966
117Phagosome_Homo sapiens_hsa041450.53241713
118Estrogen signaling pathway_Homo sapiens_hsa049150.53215189
119Gastric acid secretion_Homo sapiens_hsa049710.52572763
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51641264
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51499276
122Rap1 signaling pathway_Homo sapiens_hsa040150.51470440
123Choline metabolism in cancer_Homo sapiens_hsa052310.50106788
124Viral carcinogenesis_Homo sapiens_hsa052030.49483118
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48989676
126Pathways in cancer_Homo sapiens_hsa052000.48184465
127Metabolic pathways_Homo sapiens_hsa011000.47695522
128Adherens junction_Homo sapiens_hsa045200.47006190
129Fatty acid elongation_Homo sapiens_hsa000620.46888887
130Systemic lupus erythematosus_Homo sapiens_hsa053220.45493706
131Olfactory transduction_Homo sapiens_hsa047400.45335473
132Sulfur metabolism_Homo sapiens_hsa009200.44758216
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44033477
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43636790
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43635911
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.43373786
137Cardiac muscle contraction_Homo sapiens_hsa042600.42550396
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42526836
139Dorso-ventral axis formation_Homo sapiens_hsa043200.42277372
140AMPK signaling pathway_Homo sapiens_hsa041520.40529796
141Fanconi anemia pathway_Homo sapiens_hsa034600.40177010
142VEGF signaling pathway_Homo sapiens_hsa043700.39266773
143TGF-beta signaling pathway_Homo sapiens_hsa043500.37300312
144Salmonella infection_Homo sapiens_hsa051320.36145443
145Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35195328
146Amphetamine addiction_Homo sapiens_hsa050310.35049975
147Fatty acid metabolism_Homo sapiens_hsa012120.34517092
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29484243
149Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28176792
150Propanoate metabolism_Homo sapiens_hsa006400.26696514

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