ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	keratinization (GO:0031424)	9.83835165
2	intermediate filament organization (GO:0045109)	9.53751274
3	peptide cross-linking (GO:0018149)	6.97471210
4	establishment of skin barrier (GO:0061436)	6.73366698
5	bundle of His cell to Purkinje myocyte communication (GO:0086069)	6.55532978
6	hair follicle morphogenesis (GO:0031069)	6.47012404
7	virion attachment to host cell (GO:0019062)	6.35429974
8	adhesion of symbiont to host cell (GO:0044650)	6.35429974
9	hemidesmosome assembly (GO:0031581)	6.29903430
10	regulation of water loss via skin (GO:0033561)	6.03557967
11	keratinocyte differentiation (GO:0030216)	5.85165890
12	epidermis development (GO:0008544)	5.77681548
13	adhesion of symbiont to host (GO:0044406)	5.46156927
14	citrulline biosynthetic process (GO:0019240)	5.42436008
15	hair cycle process (GO:0022405)	5.33626496
16	molting cycle process (GO:0022404)	5.33626496
17	intermediate filament cytoskeleton organization (GO:0045104)	5.23479169
18	intermediate filament-based process (GO:0045103)	5.08685501
19	regulation of hair follicle development (GO:0051797)	4.93267132
20	epidermal cell differentiation (GO:0009913)	4.93239235
21	tooth mineralization (GO:0034505)	4.67969356
22	keratinocyte development (GO:0003334)	4.60293103
23	cell wall macromolecule catabolic process (GO:0016998)	4.53572667
24	cell wall macromolecule metabolic process (GO:0044036)	4.53572667
25	polarized epithelial cell differentiation (GO:0030859)	4.45260218
26	skin morphogenesis (GO:0043589)	4.45046388
27	bone trabecula formation (GO:0060346)	4.42209325
28	intestinal epithelial cell development (GO:0060576)	4.28666081
29	positive regulation of hair cycle (GO:0042635)	4.13060897
30	positive regulation of hair follicle development (GO:0051798)	4.13060897
31	positive regulation of keratinocyte differentiation (GO:0045618)	4.12536602
32	negative regulation of keratinocyte proliferation (GO:0010839)	4.08783858
33	multicellular organismal water homeostasis (GO:0050891)	4.07848994
34	hair follicle development (GO:0001942)	4.01700323
35	regulation of hair cycle (GO:0042634)	3.99468120
36	branching involved in labyrinthine layer morphogenesis (GO:0060670)	3.97638754
37	planar cell polarity pathway involved in neural tube closure (GO:0090179)	3.97573742
38	cranial suture morphogenesis (GO:0060363)	3.97116405
39	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.89418640
40	regulation of transforming growth factor beta2 production (GO:0032909)	3.82494902
41	negative regulation of epidermis development (GO:0045683)	3.75284760
42	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	3.74090793
43	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	3.73967585
44	cell surface receptor signaling pathway involved in heart development (GO:0061311)	3.61385513
45	gap junction assembly (GO:0016264)	3.60973690
46	atrioventricular valve morphogenesis (GO:0003181)	3.57703692
47	cell differentiation involved in embryonic placenta development (GO:0060706)	3.57281661
48	branching involved in salivary gland morphogenesis (GO:0060445)	3.55710701
49	wound healing, spreading of epidermal cells (GO:0035313)	3.55008062
50	negative regulation of cell fate specification (GO:0009996)	3.54765988
51	regulation of mesenchymal cell apoptotic process (GO:2001053)	3.47529616
52	regulation of keratinocyte differentiation (GO:0045616)	3.44252958
53	citrulline metabolic process (GO:0000052)	3.43881348
54	eyelid development in camera-type eye (GO:0061029)	3.41839850
55	peptidyl-arginine modification (GO:0018195)	3.41368513
56	ectoderm development (GO:0007398)	3.38998356
57	positive regulation of epidermis development (GO:0045684)	3.38963258
58	trophectodermal cell differentiation (GO:0001829)	3.37984924
59	epithelial cell maturation (GO:0002070)	3.32497540
60	water homeostasis (GO:0030104)	3.31356344
61	lateral sprouting from an epithelium (GO:0060601)	3.29589434
62	COPI coating of Golgi vesicle (GO:0048205)	3.29457408
63	Golgi transport vesicle coating (GO:0048200)	3.29457408
64	regulation of keratinocyte proliferation (GO:0010837)	3.28725171
65	positive regulation of meiotic cell cycle (GO:0051446)	3.26100324
66	ER overload response (GO:0006983)	3.22673485
67	positive regulation of Cdc42 GTPase activity (GO:0043089)	3.21635984
68	non-canonical Wnt signaling pathway (GO:0035567)	3.20286505
69	endocrine hormone secretion (GO:0060986)	3.19500116
70	ear development (GO:0043583)	3.14206794
71	regulation of epidermis development (GO:0045682)	3.11252216
72	lung-associated mesenchyme development (GO:0060484)	3.07627289
73	epithelium development (GO:0060429)	3.07393947
74	molting cycle (GO:0042303)	23.2939825
75	hair cycle (GO:0042633)	23.2939825
76	chondrocyte development (GO:0002063)	2.98364604
77	proteasome assembly (GO:0043248)	2.96751539
78	establishment of planar polarity (GO:0001736)	2.95876849
79	establishment of tissue polarity (GO:0007164)	2.95876849
80	regulation of transcription from RNA polymerase II promoter involved in heart development (GO:190121	2.91920836
81	regulation of branching involved in prostate gland morphogenesis (GO:0060687)	2.91440725
82	keratinocyte proliferation (GO:0043616)	2.88857592
83	mammary gland epithelial cell proliferation (GO:0033598)	2.85056302
84	craniofacial suture morphogenesis (GO:0097094)	2.84825774
85	outflow tract septum morphogenesis (GO:0003148)	2.84769791
86	skin development (GO:0043588)	2.82737200
87	L-alpha-amino acid transmembrane transport (GO:1902475)	2.79969126
88	ribosomal small subunit biogenesis (GO:0042274)	2.73435071
89	maternal placenta development (GO:0001893)	2.72445848
90	positive regulation of epidermal cell differentiation (GO:0045606)	2.70404554
91	tight junction assembly (GO:0070830)	2.70172391
92	branching involved in mammary gland duct morphogenesis (GO:0060444)	2.68953175
93	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	2.67761537
94	regulation of cellular amino acid metabolic process (GO:0006521)	2.66965775
95	Wnt signaling pathway, planar cell polarity pathway (GO:0060071)	2.66593570
96	regulation of epidermal cell differentiation (GO:0045604)	2.65292485
97	lymph vessel development (GO:0001945)	2.65233795
98	notochord development (GO:0030903)	2.65099944
99	ribosomal large subunit biogenesis (GO:0042273)	2.64502114
100	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	2.63297442
101	epithelial cell-cell adhesion (GO:0090136)	2.63252943
102	morphogenesis of embryonic epithelium (GO:0016331)	2.61835619
103	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	2.61770191
104	embryonic camera-type eye development (GO:0031076)	2.61531462
105	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.60798056
106	formation of translation preinitiation complex (GO:0001731)	2.59380296
107	wound healing, spreading of cells (GO:0044319)	2.59305580
108	regulation of cell proliferation involved in kidney development (GO:1901722)	2.59149858
109	heart valve morphogenesis (GO:0003179)	2.58858071
110	regulation of establishment of planar polarity (GO:0090175)	2.57919395
111	cell-substrate junction assembly (GO:0007044)	2.57689294
112	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.57657054
113	diol metabolic process (GO:0034311)	2.57605650
114	ribonucleoprotein complex biogenesis (GO:0022613)	2.57183117
115	ribosome biogenesis (GO:0042254)	2.56511885
116	prostanoid biosynthetic process (GO:0046457)	2.54132189
117	prostaglandin biosynthetic process (GO:0001516)	2.54132189
118	regulation of cardioblast differentiation (GO:0051890)	2.53874206
119	negative regulation of catenin import into nucleus (GO:0035414)	2.53672630
120	protein autoprocessing (GO:0016540)	2.53044996
121	viral transcription (GO:0019083)	2.52186259
122	hippo signaling (GO:0035329)	2.50355202
123	cornea development in camera-type eye (GO:0061303)	2.50020380
124	negative regulation of cell fate commitment (GO:0010454)	2.49974797
125	cell-cell junction assembly (GO:0007043)	2.48815300
126	oocyte development (GO:0048599)	2.48504576
127	regulation of hippo signaling (GO:0035330)	2.48290337
128	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.47747380
129	ribosome assembly (GO:0042255)	2.47292756
130	establishment of apical/basal cell polarity (GO:0035089)	2.47210566
131	epithelial cell differentiation involved in prostate gland development (GO:0060742)	2.47110930
132	anatomical structure regression (GO:0060033)	2.47045965
133	translational termination (GO:0006415)	2.44397252
134	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.43428169
135	amyloid precursor protein metabolic process (GO:0042982)	2.43328481
136	outer ear morphogenesis (GO:0042473)	2.39745894
137	negative regulation of epidermal cell differentiation (GO:0045605)	2.35875052
138	neural crest cell development (GO:0014032)	2.35465316
139	regulation of cell fate specification (GO:0042659)	2.33683744
140	cardiac right ventricle morphogenesis (GO:0003215)	2.33672603
141	regulation of ruffle assembly (GO:1900027)	2.32693955
142	regulation of heart morphogenesis (GO:2000826)	2.29397981
143	digestive tract morphogenesis (GO:0048546)	2.29181203
144	cochlea morphogenesis (GO:0090103)	2.29163539
145	ventricular cardiac muscle cell action potential (GO:0086005)	2.28976635
146	face morphogenesis (GO:0060325)	2.28949840
147	* odontogenesis of dentin-containing tooth (GO:0042475)	2.28565435
148	desmosome organization (GO:0002934)	11.5495731

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.56664794
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	3.90181627
3	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.76810523
4	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.32495784
5	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.96447304
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.62464573
7	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.46156215
8	SOX9_24532713_ChIP-Seq_HFSC_Mouse	2.37342625
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.33655590
10	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.13941325
11	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.13516602
12	E2F7_22180533_ChIP-Seq_HELA_Human	2.08693817
13	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.07577821
14	AR_21909140_ChIP-Seq_LNCAP_Human	2.06242145
15	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.03121175
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.00573095
17	TP63_17297297_ChIP-ChIP_HaCaT_Human	14.5552941
18	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.99943052
19	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.99943052
20	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.92050303
21	EGR1_19032775_ChIP-ChIP_M12_Human	1.91867376
22	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.88367930
23	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.82002636
24	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.76418499
25	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.74725654
26	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.74587873
27	DCP1A_22483619_ChIP-Seq_HELA_Human	1.72176283
28	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.71194739
29	* TP53_20018659_ChIP-ChIP_R1E_Mouse	1.71095788
30	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.66696785
31	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.64768985
32	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.63486694
33	XRN2_22483619_ChIP-Seq_HELA_Human	1.61524448
34	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.60631159
35	* RACK7_27058665_Chip-Seq_MCF-7_Human	1.60047122
36	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.53191715
37	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.52147698
38	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.51687356
39	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.49136753
40	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.48480726
41	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.47420637
42	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.46615471
43	ATF3_27146783_Chip-Seq_COLON_Human	1.43172591
44	KDM5A_27292631_Chip-Seq_BREAST_Human	1.42682713
45	* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.41881105
46	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.41677846
47	* ELF5_23300383_ChIP-Seq_T47D_Human	1.39177752
48	* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.37353527
49	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.35814576
50	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	1.35026435
51	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.33895778
52	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.33611683
53	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.33330503
54	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.32862849
55	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.32014185
56	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.31722099
57	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.31626505
58	ZNF263_19887448_ChIP-Seq_K562_Human	1.31282338
59	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.30757786
60	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.30329983
61	CTCF_20526341_ChIP-Seq_ESCs_Human	1.29246261
62	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.27628441
63	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.26055622
64	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.24977121
65	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.23583136
66	* TP63_22573176_ChIP-Seq_HFKS_Human	1.22575982
67	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.22079619
68	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.21929620
69	KLF5_25053715_ChIP-Seq_YYC3_Human	1.21836369
70	E2F1_20622854_ChIP-Seq_HELA_Human	1.21258090
71	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.20805637
72	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.20299326
73	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.19852620
74	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.19847356
75	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.18613036
76	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.18445175
77	* CTCF_27219007_Chip-Seq_Bcells_Human	1.18147153
78	AHR_22903824_ChIP-Seq_MCF-7_Human	1.17252364
79	GABP_19822575_ChIP-Seq_HepG2_Human	1.16576414
80	TP63_23658742_ChIP-Seq_EP156T_Human	1.15958086
81	* MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.14673963
82	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.12470799
83	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.10685320
84	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10254405
85	TTF2_22483619_ChIP-Seq_HELA_Human	1.10158700
86	* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.09356105
87	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.09302575
88	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.09091449
89	SMC4_20622854_ChIP-Seq_HELA_Human	1.08051895
90	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.07997412
91	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.07383089
92	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.07346723
93	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.07215651
94	RXR_22108803_ChIP-Seq_LS180_Human	1.07151536
95	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.06885828
96	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.06521565
97	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.06500011
98	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.06420107
99	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.04948515
100	GATA4_25053715_ChIP-Seq_YYC3_Human	1.04776325
101	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.04519541
102	SOX2_20726797_ChIP-Seq_SW620_Human	1.04371763
103	* BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.04362761
104	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.04121885
105	NANOG_20526341_ChIP-Seq_ESCs_Human	1.03853259
106	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.03609215
107	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.01312762
108	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.00814598
109	TP53_18474530_ChIP-ChIP_U2OS_Human	1.00091691
110	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.99719149
111	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.98682253
112	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.98624243
113	CHD1_26751641_Chip-Seq_LNCaP_Human	0.97793631
114	* KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.96883479
115	CJUN_26792858_Chip-Seq_BT549_Human	0.96569822
116	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.95704523
117	* LXR_22292898_ChIP-Seq_THP-1_Human	0.95348922
118	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.94787565
119	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.94783189
120	* RNF2_27304074_Chip-Seq_ESCs_Mouse	0.94436849
121	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.93873626
122	* SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.93602468
123	* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.93201092
124	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.93192886
125	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.93140959
126	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.92774088
127	ERG_20517297_ChIP-Seq_VCAP_Human	0.91834006
128	* ELK3_25401928_ChIP-Seq_HUVEC_Human	0.91387277
129	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.90890370
130	KDM2B_26808549_Chip-Seq_K562_Human	0.89339282
131	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.89115215
132	* RING1B_27294783_Chip-Seq_ESCs_Mouse	0.89092741
133	GATA6_25053715_ChIP-Seq_YYC3_Human	0.88894648
134	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.87760614
135	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.87760614
136	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.87760614
137	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.87401943
138	BCOR_27268052_Chip-Seq_Bcells_Human	0.87373127
139	* RING1B_27294783_Chip-Seq_NPCs_Mouse	0.87249310
140	* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.87127852
141	TAF2_19829295_ChIP-Seq_ESCs_Human	0.86186724
142	KDM2B_26808549_Chip-Seq_JURKAT_Human	0.85913927
143	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.85664082
144	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.85440841
145	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.85166846
146	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.85049440
147	* EZH2_27304074_Chip-Seq_ESCs_Mouse	0.84549347
148	* JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.84461401
149	BCL6_27268052_Chip-Seq_Bcells_Human	0.84416482
150	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.84234679
151	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.84161152
152	P53_21459846_ChIP-Seq_SAOS-2_Human	0.82415039
153	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.82377054
154	TP53_22127205_ChIP-Seq_IMR90_Human	0.82306762
155	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.82195102
156	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.81810973
157	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.81456084
158	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.81163319
159	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.80638683
160	P68_20966046_ChIP-Seq_HELA_Human	0.79555012
161	* PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.79095619
162	PHF8_20622854_ChIP-Seq_HELA_Human	0.77842305
163	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.76853945
164	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.76615601
165	CEBPB_22108803_ChIP-Seq_LS180_Human	0.76464423

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	6.77325304
2	MP0002098_abnormal_vibrissa_morphology	5.64213601
3	MP0002796_impaired_skin_barrier	5.11423344
4	MP0000383_abnormal_hair_follicle	5.10441228
5	MP0005275_abnormal_skin_tensile	4.94682400
6	* MP0000647_abnormal_sebaceous_gland	4.51889547
7	MP0010678_abnormal_skin_adnexa	4.32205908
8	MP0010234_abnormal_vibrissa_follicle	3.88635079
9	MP0003705_abnormal_hypodermis_morpholog	3.63089127
10	MP0003878_abnormal_ear_physiology	3.35893989
11	MP0005377_hearing/vestibular/ear_phenot	3.35893989
12	* MP0000377_abnormal_hair_follicle	3.34015062
13	MP0005501_abnormal_skin_physiology	3.30692853
14	MP0002254_reproductive_system_inflammat	2.90279195
15	MP0009379_abnormal_foot_pigmentation	2.83445008
16	* MP0000427_abnormal_hair_cycle	2.75065501
17	* MP0001216_abnormal_epidermal_layer	2.53145210
18	MP0002060_abnormal_skin_morphology	2.45258459
19	MP0004381_abnormal_hair_follicle	2.39475672
20	MP0010771_integument_phenotype	2.24387972
21	MP0003941_abnormal_skin_development	2.22904410
22	MP0003453_abnormal_keratinocyte_physiol	2.13455631
23	MP0004782_abnormal_surfactant_physiolog	2.08609423
24	MP0000762_abnormal_tongue_morphology	2.03979389
25	MP0009053_abnormal_anal_canal	1.93444854
26	MP0000566_synostosis	1.91308671
27	MP0004947_skin_inflammation	1.89165465
28	* MP0001243_abnormal_dermal_layer	1.86566620
29	MP0010030_abnormal_orbit_morphology	1.80654423
30	* MP0000367_abnormal_coat/_hair	1.70759525
31	MP0003693_abnormal_embryo_hatching	1.66069887
32	MP0000467_abnormal_esophagus_morphology	1.57086606
33	MP0002234_abnormal_pharynx_morphology	1.55171606
34	MP0005409_darkened_coat_color	1.53180936
35	MP0003566_abnormal_cell_adhesion	1.50224142
36	MP0001346_abnormal_lacrimal_gland	1.49462774
37	MP0009931_abnormal_skin_appearance	1.43385097
38	MP0004233_abnormal_muscle_weight	1.42938910
39	MP0004957_abnormal_blastocyst_morpholog	1.21272349
40	MP0009780_abnormal_chondrocyte_physiolo	1.16409890
41	MP0009672_abnormal_birth_weight	1.15142160
42	MP0004264_abnormal_extraembryonic_tissu	1.13718233
43	MP0002009_preneoplasia	1.10991359
44	MP0002877_abnormal_melanocyte_morpholog	1.10071604
45	MP0002282_abnormal_trachea_morphology	1.09050918
46	MP0002876_abnormal_thyroid_physiology	1.08284379
47	MP0001881_abnormal_mammary_gland	1.07080121
48	MP0003385_abnormal_body_wall	1.05819081
49	MP0001191_abnormal_skin_condition	1.05455815
50	MP0003755_abnormal_palate_morphology	1.05195125
51	MP0001340_abnormal_eyelid_morphology	1.04697610
52	MP0002095_abnormal_skin_pigmentation	1.02032317
53	MP0000537_abnormal_urethra_morphology	1.01799408
54	MP0003936_abnormal_reproductive_system	1.01377759
55	MP0005503_abnormal_tendon_morphology	1.00786035
56	MP0008004_abnormal_stomach_pH	0.97455596
57	MP0004185_abnormal_adipocyte_glucose	0.97283182
58	MP0002249_abnormal_larynx_morphology	0.93499601
59	MP0005408_hypopigmentation	0.92328121
60	MP0003806_abnormal_nucleotide_metabolis	0.89904453
61	MP0010094_abnormal_chromosome_stability	0.88824529
62	MP0003950_abnormal_plasma_membrane	0.85237163
63	MP0006054_spinal_hemorrhage	0.84937588
64	MP0008438_abnormal_cutaneous_collagen	0.83864654
65	MP0005248_abnormal_Harderian_gland	0.82756359
66	MP0005367_renal/urinary_system_phenotyp	0.81266911
67	MP0000516_abnormal_urinary_system	0.81266911
68	MP0009250_abnormal_appendicular_skeleto	0.80892001
69	MP0000432_abnormal_head_morphology	0.80545734
70	MP0000627_abnormal_mammary_gland	0.79701389
71	MP0001849_ear_inflammation	0.79318803
72	MP0003937_abnormal_limbs/digits/tail_de	0.79274333
73	MP0004019_abnormal_vitamin_homeostasis	0.78523975
74	MP0003718_maternal_effect	0.78447419
75	MP0002111_abnormal_tail_morphology	0.77214913
76	MP0001661_extended_life_span	0.77041835
77	MP0005508_abnormal_skeleton_morphology	0.75440451
78	MP0001697_abnormal_embryo_size	0.74596456
79	MP0010307_abnormal_tumor_latency	0.73207918
80	MP0001851_eye_inflammation	0.73197459
81	MP0003315_abnormal_perineum_morphology	0.73083372
82	MP0003077_abnormal_cell_cycle	0.72506083
83	MP0001672_abnormal_embryogenesis/_devel	0.71343262
84	MP0005380_embryogenesis_phenotype	0.71343262
85	MP0004272_abnormal_basement_membrane	0.70564170
86	MP0002177_abnormal_outer_ear	0.70021678
87	MP0002697_abnormal_eye_size	0.69754129
88	MP0004858_abnormal_nervous_system	0.69601415
89	MP0003984_embryonic_growth_retardation	0.68991666
90	MP0003935_abnormal_craniofacial_develop	0.68975696
91	MP0005023_abnormal_wound_healing	0.68627116
92	MP0002088_abnormal_embryonic_growth/wei	0.68018116
93	MP0005076_abnormal_cell_differentiation	0.67022435
94	* MP0002086_abnormal_extraembryonic_tissu	0.67006248
95	MP0002160_abnormal_reproductive_system	0.66755477
96	MP0005375_adipose_tissue_phenotype	0.66654399
97	MP0000428_abnormal_craniofacial_morphol	0.65630672
98	MP0009697_abnormal_copulation	0.65471562
99	MP0008932_abnormal_embryonic_tissue	0.65069339
100	MP0000358_abnormal_cell_content/	0.63203195
101	MP0002233_abnormal_nose_morphology	0.62302808
102	MP0000350_abnormal_cell_proliferation	0.61750087
103	MP0002109_abnormal_limb_morphology	0.60467541
104	MP0002085_abnormal_embryonic_tissue	0.60271226
105	MP0005623_abnormal_meninges_morphology	0.60002550
106	MP0001727_abnormal_embryo_implantation	0.59925355
107	MP0002653_abnormal_ependyma_morphology	0.59649147
108	MP0009384_cardiac_valve_regurgitation	0.59235650
109	MP0004197_abnormal_fetal_growth/weight/	0.58575934
110	MP0005058_abnormal_lysosome_morphology	0.57950527
111	MP0003186_abnormal_redox_activity	0.57631562
112	* MP0002080_prenatal_lethality	0.57505410
113	* MP0001730_embryonic_growth_arrest	0.57475499
114	MP0003191_abnormal_cellular_cholesterol	0.57361699
115	MP0001784_abnormal_fluid_regulation	0.57287257
116	MP0003938_abnormal_ear_development	0.56685031
117	MP0000013_abnormal_adipose_tissue	0.56370649
118	MP0000470_abnormal_stomach_morphology	0.55802189
119	MP0004885_abnormal_endolymph	0.55430341
120	MP0002896_abnormal_bone_mineralization	0.54031926
121	MP0006035_abnormal_mitochondrial_morpho	0.53931646
122	MP0005257_abnormal_intraocular_pressure	0.53661539
123	MP0003111_abnormal_nucleus_morphology	0.53202094
124	MP0003638_abnormal_response/metabolism_	0.52943519
125	MP0002115_abnormal_skeleton_extremities	0.52421339
126	MP0000049_abnormal_middle_ear	0.51949545
127	MP0002089_abnormal_postnatal_growth/wei	0.51468598
128	MP0002932_abnormal_joint_morphology	0.51448847
129	MP0000163_abnormal_cartilage_morphology	0.50539720
130	MP0003123_paternal_imprinting	0.49989880
131	MP0002116_abnormal_craniofacial_bone	0.49093609
132	MP0001286_abnormal_eye_development	0.48960478
133	MP0005451_abnormal_body_composition	0.48385757
134	MP0000003_abnormal_adipose_tissue	0.48153991
135	MP0000733_abnormal_muscle_development	0.45981975
136	MP0004134_abnormal_chest_morphology	0.44436392
137	MP0010352_gastrointestinal_tract_polyps	0.43118164
138	MP0005187_abnormal_penis_morphology	0.42496668
139	MP0002938_white_spotting	0.40303822
140	MP0005193_abnormal_anterior_eye	0.39987544
141	MP0003122_maternal_imprinting	0.39890101
142	MP0001542_abnormal_bone_strength	0.39547845
143	MP0003942_abnormal_urinary_system	0.38787064
144	MP0003115_abnormal_respiratory_system	0.38497857
145	MP0000465_gastrointestinal_hemorrhage	0.38408889
146	MP0002092_abnormal_eye_morphology	0.37761009
147	MP0000462_abnormal_digestive_system	0.37509406
148	MP0001299_abnormal_eye_distance/	0.37358500
149	MP0005075_abnormal_melanosome_morpholog	0.36434954

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	9.80104604
2	* Woolly hair (HP:0002224)	8.11623947
3	Slow-growing hair (HP:0002217)	7.19718581
4	Abnormality of hair growth rate (HP:0011363)	7.19718581
5	Brittle hair (HP:0002299)	6.16257093
6	Abnormal hair laboratory examination (HP:0003328)	6.03393526
7	Abnormality of nail color (HP:0100643)	5.38868572
8	Nail dystrophy (HP:0008404)	5.25882921
9	Follicular hyperkeratosis (HP:0007502)	4.86231227
10	Right ventricular cardiomyopathy (HP:0011663)	4.57890620
11	Plantar hyperkeratosis (HP:0007556)	4.47450299
12	Onycholysis (HP:0001806)	4.36476686
13	Palmoplantar hyperkeratosis (HP:0000972)	4.33125295
14	Sparse eyelashes (HP:0000653)	4.28316232
15	Milia (HP:0001056)	4.26655435
16	Alopecia of scalp (HP:0002293)	4.16435351
17	Palmar hyperkeratosis (HP:0010765)	4.09514322
18	* Fragile nails (HP:0001808)	3.90332539
19	Increased IgE level (HP:0003212)	3.70845413
20	Fine hair (HP:0002213)	3.65547066
21	Abnormality of the parietal bone (HP:0002696)	3.57845914
22	Congenital, generalized hypertrichosis (HP:0004540)	3.49594083
23	Sparse lateral eyebrow (HP:0005338)	3.29333111
24	Septate vagina (HP:0001153)	3.28795492
25	Thick nail (HP:0001805)	3.23840077
26	Aplasia cutis congenita (HP:0001057)	3.23093109
27	Natal tooth (HP:0000695)	3.12515075
28	Erythema (HP:0010783)	3.12283699
29	Abnormality of secondary sexual hair (HP:0009888)	2.91158700
30	Abnormality of the axillary hair (HP:0100134)	2.91158700
31	Hypokinesia (HP:0002375)	2.83464921
32	Advanced eruption of teeth (HP:0006288)	2.82020877
33	Oral leukoplakia (HP:0002745)	2.79824081
34	Bilateral sensorineural hearing impairment (HP:0008619)	2.78766220
35	Parakeratosis (HP:0001036)	2.72543068
36	Curly hair (HP:0002212)	2.70499303
37	Erythroderma (HP:0001019)	2.69857290
38	Ridged nail (HP:0001807)	2.67416576
39	Hypoparathyroidism (HP:0000829)	2.64320293
40	Lip pit (HP:0100267)	2.61205308
41	Selective tooth agenesis (HP:0001592)	2.61020992
42	Atrophic scars (HP:0001075)	2.54458976
43	Concave nail (HP:0001598)	2.47498372
44	Sparse scalp hair (HP:0002209)	2.45765453
45	Absent eyelashes (HP:0000561)	2.43100629
46	Congenital ichthyosiform erythroderma (HP:0007431)	2.34321828
47	Paralysis (HP:0003470)	2.33149042
48	Renal tubular acidosis (HP:0001947)	2.32627958
49	Increased circulating renin level (HP:0000848)	2.30710054
50	Breast hypoplasia (HP:0003187)	2.29560595
51	Down-sloping shoulders (HP:0200021)	2.29150114
52	Abnormality of the salivary glands (HP:0010286)	2.25035300
53	Nasolacrimal duct obstruction (HP:0000579)	2.22192972
54	Abnormal blistering of the skin (HP:0008066)	2.21243429
55	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.18631858
56	Short 4th metacarpal (HP:0010044)	2.18631858
57	Trismus (HP:0000211)	2.16826433
58	Depressed nasal tip (HP:0000437)	2.10333651
59	Cervical subluxation (HP:0003308)	2.10234415
60	Abnormality of the distal phalanges of the toes (HP:0010182)	2.07820692
61	Abnormality of the aortic arch (HP:0012303)	2.07530531
62	Diaphragmatic weakness (HP:0009113)	2.05707322
63	Type 1 muscle fiber predominance (HP:0003803)	2.03136971
64	Hamartoma of the eye (HP:0010568)	2.00671795
65	Corneal erosion (HP:0200020)	2.00642367
66	Hypotrichosis (HP:0001006)	10.7256352
67	Hypohidrosis (HP:0000966)	1.99727234
68	Pterygium (HP:0001059)	1.99006485
69	Amniotic constriction ring (HP:0009775)	1.94243897
70	Abnormality of placental membranes (HP:0011409)	1.94243897
71	Absent eyebrow (HP:0002223)	1.93964033
72	Ventricular tachycardia (HP:0004756)	1.91658309
73	Abnormality of the lacrimal duct (HP:0011481)	1.91231805
74	Blepharitis (HP:0000498)	1.90975481
75	Recurrent corneal erosions (HP:0000495)	1.90602926
76	Seborrheic dermatitis (HP:0001051)	1.89957358
77	Increased connective tissue (HP:0009025)	1.86913828
78	Hyporeflexia of lower limbs (HP:0002600)	1.86862332
79	Dry hair (HP:0011359)	1.85091927
80	Abnormality of the umbilical cord (HP:0010881)	1.82823734
81	Facial cleft (HP:0002006)	1.82782813
82	Abnormality of the distal phalanx of the thumb (HP:0009617)	1.82556749
83	Ankle contracture (HP:0006466)	1.81989837
84	Fragile skin (HP:0001030)	1.80818572
85	Aplasia of the musculature (HP:0100854)	1.78674978
86	Abnormality of the nasal septum (HP:0000419)	1.78555957
87	Widely patent fontanelles and sutures (HP:0004492)	1.77936585
88	Abnormalities of placenta or umbilical cord (HP:0001194)	1.77879110
89	Anonychia (HP:0001798)	1.77504684
90	Fatigable weakness (HP:0003473)	1.77148083
91	Abnormality of the neuromuscular junction (HP:0003398)	1.77148083
92	Distal lower limb muscle weakness (HP:0009053)	1.76552450
93	Neonatal short-limb short stature (HP:0008921)	1.76261226
94	Ectropion (HP:0000656)	1.74507833
95	Neck muscle weakness (HP:0000467)	1.73676349
96	Axonal loss (HP:0003447)	1.73069446
97	Palmoplantar keratoderma (HP:0000982)	1.72360210
98	Tetany (HP:0001281)	1.71809067
99	Abnormality of cells of the erythroid lineage (HP:0012130)	1.71605444
100	Protrusio acetabuli (HP:0003179)	1.71491544
101	Abnormality of magnesium homeostasis (HP:0004921)	1.70003399
102	Hypoplastic labia majora (HP:0000059)	1.69518865
103	Pruritus (HP:0000989)	1.66003948
104	Short clavicles (HP:0000894)	1.65979003
105	Abnormality of the nasolacrimal system (HP:0000614)	1.65676570
106	* Amelogenesis imperfecta (HP:0000705)	1.63313664
107	Premature rupture of membranes (HP:0001788)	1.62095541
108	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.61987160
109	Acanthosis nigricans (HP:0000956)	1.60661536
110	Rough bone trabeculation (HP:0100670)	1.59468872
111	Abnormality of the gastric mucosa (HP:0004295)	1.59336331
112	Hypokalemic alkalosis (HP:0001949)	1.59305582
113	High anterior hairline (HP:0009890)	1.58314378
114	Aplasia of the phalanges of the hand (HP:0009802)	1.58276113
115	Aplasia involving bones of the extremities (HP:0009825)	1.58276113
116	Aplasia involving bones of the upper limbs (HP:0009823)	1.58276113
117	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.57545937
118	Epiphyseal dysplasia (HP:0002656)	1.57452371
119	Proximal tubulopathy (HP:0000114)	1.57050299
120	Abnormality of the 4th metacarpal (HP:0010012)	1.56216961
121	Hypoplasia of dental enamel (HP:0006297)	1.55706568
122	Distal arthrogryposis (HP:0005684)	1.55050419
123	Abnormality of the labia majora (HP:0012881)	1.54840485
124	Ulnar deviation of the wrist (HP:0003049)	1.53847386
125	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.52721777
126	Ureteral duplication (HP:0000073)	1.52421001
127	Round ear (HP:0100830)	1.51177496
128	Neonatal death (HP:0003811)	1.50465707
129	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.48361828
130	Shallow orbits (HP:0000586)	1.46453549
131	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.46156886
132	Bronchomalacia (HP:0002780)	1.45354140
133	Abnormality of the 2nd finger (HP:0004100)	1.45213491
134	Laryngomalacia (HP:0001601)	1.43031944
135	Conjunctival hamartoma (HP:0100780)	1.42985103
136	Premature loss of primary teeth (HP:0006323)	1.42484225
137	Skin pits (HP:0100276)	1.38221963
138	Wide cranial sutures (HP:0010537)	1.37930631
139	Short phalanx of the thumb (HP:0009660)	1.37868790
140	Absent hair (HP:0002298)	1.37088142
141	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	1.37047856
142	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.35972730
143	Popliteal pterygium (HP:0009756)	1.34370251
144	Deformed tarsal bones (HP:0008119)	1.33247773
145	Unilateral renal agenesis (HP:0000122)	1.32780753
146	Mesomelia (HP:0003027)	1.32336036

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK39	5.02590000
2	MAPKAPK3	4.68272833
3	LATS1	4.18449279
4	WNK4	4.07994112
5	OXSR1	3.69765996
6	EPHB2	3.65600511
7	PBK	3.62755431
8	EPHA2	3.54121779
9	RPS6KB2	3.34800557
10	MAP3K3	3.33596728
11	FER	3.23303643
12	NME2	2.59177372
13	TAOK1	2.54114244
14	EEF2K	2.34249390
15	ERN1	2.27353829
16	EIF2AK1	2.15703528
17	FGFR2	2.10152642
18	TESK2	2.09393807
19	TRIB3	1.95739841
20	WEE1	1.92785753
21	LATS2	1.90028992
22	FGFR1	1.89677878
23	DDR2	1.85699903
24	AKT3	1.82759398
25	BUB1	1.69712236
26	TESK1	1.64901320
27	MAP3K12	1.61296085
28	STK38L	1.58566979
29	CDK6	1.53403095
30	PIK3CG	1.49574472
31	SMG1	1.49158795
32	VRK2	1.43361792
33	PDK2	1.42903123
34	TGFBR1	1.40654002
35	MAP3K11	1.35982426
36	CDK12	1.34013733
37	STK16	1.32610987
38	NME1	1.30676307
39	FGFR3	1.29158240
40	TTN	1.27520262
41	MAP3K6	1.23304737
42	MAP3K10	1.22401004
43	MAP3K2	1.22225322
44	TRPM7	1.21884476
45	ERBB3	1.20673939
46	SIK1	1.20338211
47	STK3	1.18842006
48	MKNK1	1.18817548
49	BRD4	1.17505552
50	NLK	1.11345727
51	MAPKAPK2	1.07913811
52	SCYL2	1.07285713
53	STK24	1.06933034
54	PTK6	1.03758317
55	PKN2	1.02269262
56	TTK	1.01777084
57	MUSK	1.00194703
58	ICK	0.99229762
59	PRKCI	0.97894231
60	RPS6KA4	0.97277016
61	PNCK	0.96806318
62	DYRK1B	0.94883699
63	BCR	0.93787820
64	MST1R	0.93392794
65	MAP2K2	0.92670192
66	BMPR1B	0.90256208
67	PDGFRA	0.88563411
68	MAP2K3	0.87512080
69	RIPK1	0.86722170
70	CDK9	0.85462510
71	EIF2AK3	0.84637851
72	ERBB2	0.82211724
73	PRKG2	0.80711020
74	MTOR	0.80679735
75	BMX	0.79262782
76	MAP3K7	0.79063018
77	MKNK2	0.78831045
78	NEK1	0.78488980
79	PLK4	0.77164967
80	PTK2	0.76637151
81	MAP2K6	0.72879076
82	AURKA	0.71011552
83	CDK7	0.70768326
84	NUAK1	0.70552461
85	CHUK	0.68918719
86	MST4	0.68198346
87	NEK6	0.67533139
88	LRRK2	0.66223545
89	TAF1	0.62693426
90	MAP2K1	0.61340684
91	BRSK1	0.59884707
92	LIMK1	0.59654727
93	EPHB1	0.59011395
94	DMPK	0.59010537
95	STK10	0.58674165
96	CHEK2	0.58435853
97	MAP3K1	0.57933944
98	PLK1	0.57599167
99	ABL2	0.57396891
100	MATK	0.56726548
101	SGK3	0.56369857
102	MET	0.55825054
103	ROCK1	0.55115371
104	AURKB	0.54591971
105	PIM2	0.54238721
106	MAPKAPK5	0.53715681
107	RPS6KA1	0.49949009
108	BRSK2	0.48201191
109	MYLK	0.47855668
110	SRPK1	0.44612260
111	OBSCN	0.44181615
112	CDK8	0.43466109
113	TNIK	0.43089072
114	CAMK2G	0.41962465
115	AKT2	0.41398686
116	SGK2	0.41255528
117	PIM1	0.40390420
118	STK38	0.40175090
119	MAPK11	0.39935657
120	CDK4	0.39435149
121	MARK3	0.38292490
122	GSK3A	0.37555807
123	PIK3CA	0.37227105
124	CDK3	0.36338815
125	MAPK8	0.36330773
126	PAK2	0.35162548
127	CHEK1	0.35054377
128	CSNK1G1	0.34187934
129	MAPK9	0.33769578
130	PAK4	0.33414521
131	ZAK	0.32967230
132	MAP3K9	0.29723997
133	SGK1	0.29429431
134	STK11	0.29410350
135	MAP3K8	0.28359314
136	ILK	0.28109933
137	PRKD1	0.27985865
138	PRKD2	0.26564039
139	SIK3	0.26352137
140	STK4	0.26008785
141	MAPK1	0.25205784
142	CSNK1E	0.24670943
143	MELK	0.23906930
144	LMTK2	0.20548262
145	PRKCD	0.20046780
146	CSNK2A1	0.19891638
147	DAPK1	0.19884731
148	FGFR4	0.18783084
149	TSSK6	0.17272557
150	PAK1	0.16796591
151	EIF2AK2	0.16541091
152	CAMK2D	0.15148199

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal cell carcinoma_Homo sapiens_hsa05217	4.85431958
2	Proteasome_Homo sapiens_hsa03050	3.76519363
3	Hedgehog signaling pathway_Homo sapiens_hsa04340	3.52391442
4	Collecting duct acid secretion_Homo sapiens_hsa04966	3.21718660
5	Hippo signaling pathway_Homo sapiens_hsa04390	2.87145306
6	Vibrio cholerae infection_Homo sapiens_hsa05110	2.58304332
7	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	2.52121595
8	ECM-receptor interaction_Homo sapiens_hsa04512	2.50613748
9	Thyroid cancer_Homo sapiens_hsa05216	2.39805364
10	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	2.28606876
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.24786359
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.12196560
13	Adherens junction_Homo sapiens_hsa04520	2.08396525
14	Proteoglycans in cancer_Homo sapiens_hsa05205	2.07596496
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.06847862
16	Folate biosynthesis_Homo sapiens_hsa00790	2.03433226
17	Melanogenesis_Homo sapiens_hsa04916	2.03075237
18	DNA replication_Homo sapiens_hsa03030	1.99712564
19	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.96470727
20	Wnt signaling pathway_Homo sapiens_hsa04310	1.92315492
21	Oxidative phosphorylation_Homo sapiens_hsa00190	1.83159754
22	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.78504294
23	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.75006222
24	Sulfur relay system_Homo sapiens_hsa04122	1.73683959
25	Endometrial cancer_Homo sapiens_hsa05213	1.73003979
26	Bladder cancer_Homo sapiens_hsa05219	1.71502623
27	Tight junction_Homo sapiens_hsa04530	1.68165449
28	Acute myeloid leukemia_Homo sapiens_hsa05221	1.65742078
29	MicroRNAs in cancer_Homo sapiens_hsa05206	1.58528824
30	Protein digestion and absorption_Homo sapiens_hsa04974	1.56676309
31	RNA transport_Homo sapiens_hsa03013	1.55334431
32	Axon guidance_Homo sapiens_hsa04360	1.52867635
33	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.51438020
34	Notch signaling pathway_Homo sapiens_hsa04330	1.47925407
35	p53 signaling pathway_Homo sapiens_hsa04115	1.46686915
36	Focal adhesion_Homo sapiens_hsa04510	1.45708973
37	Mismatch repair_Homo sapiens_hsa03430	1.38713317
38	Nucleotide excision repair_Homo sapiens_hsa03420	1.33913411
39	Base excision repair_Homo sapiens_hsa03410	1.31302497
40	Prostate cancer_Homo sapiens_hsa05215	1.31159654
41	Pathways in cancer_Homo sapiens_hsa05200	1.30243465
42	HTLV-I infection_Homo sapiens_hsa05166	1.30088826
43	Small cell lung cancer_Homo sapiens_hsa05222	1.28332904
44	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.28271622
45	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.27569858
46	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.26967325
47	Glioma_Homo sapiens_hsa05214	1.26451740
48	Non-small cell lung cancer_Homo sapiens_hsa05223	1.23787672
49	Melanoma_Homo sapiens_hsa05218	1.23545891
50	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.23528546
51	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.23234160
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.22629300
53	VEGF signaling pathway_Homo sapiens_hsa04370	1.22072663
54	Homologous recombination_Homo sapiens_hsa03440	1.21294357
55	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.19548654
56	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.17399546
57	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.15111518
58	Galactose metabolism_Homo sapiens_hsa00052	1.13564926
59	Spliceosome_Homo sapiens_hsa03040	1.07221470
60	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.06184261
61	Arginine and proline metabolism_Homo sapiens_hsa00330	1.06099697
62	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.05796601
63	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.04751361
64	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.04187785
65	Lysosome_Homo sapiens_hsa04142	1.02679121
66	Ribosome_Homo sapiens_hsa03010	1.02202188
67	Amoebiasis_Homo sapiens_hsa05146	1.01969455
68	Pyrimidine metabolism_Homo sapiens_hsa00240	1.01715389
69	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.01647556
70	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.01545398
71	Pentose phosphate pathway_Homo sapiens_hsa00030	1.00284748
72	Glutathione metabolism_Homo sapiens_hsa00480	0.98702512
73	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.96631475
74	Huntingtons disease_Homo sapiens_hsa05016	0.96453634
75	mRNA surveillance pathway_Homo sapiens_hsa03015	0.94623768
76	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.93937698
77	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.92804890
78	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.91944173
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.91602884
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.91409754
81	Ether lipid metabolism_Homo sapiens_hsa00565	0.91112268
82	Rap1 signaling pathway_Homo sapiens_hsa04015	0.89998605
83	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.89663555
84	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.88627866
85	Arginine biosynthesis_Homo sapiens_hsa00220	0.87877661
86	Renal cell carcinoma_Homo sapiens_hsa05211	0.87501477
87	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.84954641
88	Parkinsons disease_Homo sapiens_hsa05012	0.84193948
89	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.83034659
90	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.81475996
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.80634831
92	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.80531582
93	RNA polymerase_Homo sapiens_hsa03020	0.80288589
94	Ras signaling pathway_Homo sapiens_hsa04014	0.80208789
95	Pancreatic cancer_Homo sapiens_hsa05212	0.80176488
96	Caffeine metabolism_Homo sapiens_hsa00232	0.80001631
97	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.78865825
98	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.78557280
99	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.77456602
100	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.77448988
101	Cell cycle_Homo sapiens_hsa04110	0.77425566
102	Selenocompound metabolism_Homo sapiens_hsa00450	0.77226834
103	One carbon pool by folate_Homo sapiens_hsa00670	0.76892176
104	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.76612005
105	Other glycan degradation_Homo sapiens_hsa00511	0.74156591
106	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.73748344
107	Platelet activation_Homo sapiens_hsa04611	0.73674820
108	Fanconi anemia pathway_Homo sapiens_hsa03460	0.72277650
109	Carbon metabolism_Homo sapiens_hsa01200	0.72031504
110	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.71039175
111	FoxO signaling pathway_Homo sapiens_hsa04068	0.70619706
112	Fatty acid elongation_Homo sapiens_hsa00062	0.70550915
113	Sphingolipid metabolism_Homo sapiens_hsa00600	0.70531804
114	Toxoplasmosis_Homo sapiens_hsa05145	0.68243180
115	Insulin resistance_Homo sapiens_hsa04931	0.67544794
116	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.67359810
117	Pyruvate metabolism_Homo sapiens_hsa00620	0.65047860
118	Colorectal cancer_Homo sapiens_hsa05210	0.62105433
119	Hepatitis C_Homo sapiens_hsa05160	0.62015577
120	ErbB signaling pathway_Homo sapiens_hsa04012	0.60124926
121	Apoptosis_Homo sapiens_hsa04210	0.59759760
122	Alzheimers disease_Homo sapiens_hsa05010	0.57262360
123	Metabolic pathways_Homo sapiens_hsa01100	0.57115989
124	Tyrosine metabolism_Homo sapiens_hsa00350	0.57057461
125	GnRH signaling pathway_Homo sapiens_hsa04912	0.56130769
126	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.55909655
127	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.55103524
128	Mineral absorption_Homo sapiens_hsa04978	0.55078343
129	Basal transcription factors_Homo sapiens_hsa03022	0.54816642
130	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.52094487
131	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.51300074
132	Prolactin signaling pathway_Homo sapiens_hsa04917	0.50788034
133	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.50033057
134	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.49907345
135	Phenylalanine metabolism_Homo sapiens_hsa00360	0.49244816
136	beta-Alanine metabolism_Homo sapiens_hsa00410	0.48887001
137	Histidine metabolism_Homo sapiens_hsa00340	0.48080392
138	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.47433626
139	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.46899726
140	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.45461172
141	Long-term depression_Homo sapiens_hsa04730	0.44742795
142	Antigen processing and presentation_Homo sapiens_hsa04612	0.43196439
143	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.42972254
144	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.41802408
145	RNA degradation_Homo sapiens_hsa03018	0.41583788
146	Salmonella infection_Homo sapiens_hsa05132	0.40755615
147	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.39726587
148	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.39129946
149	Viral carcinogenesis_Homo sapiens_hsa05203	0.38971060
150	MAPK signaling pathway_Homo sapiens_hsa04010	0.38009453
151	Insulin signaling pathway_Homo sapiens_hsa04910	0.37574865
152	Hepatitis B_Homo sapiens_hsa05161	0.37276431
153	Endocytosis_Homo sapiens_hsa04144	0.37224908
154	Estrogen signaling pathway_Homo sapiens_hsa04915	0.36943431
155	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.36344490
156	mTOR signaling pathway_Homo sapiens_hsa04150	0.35653840
157	Viral myocarditis_Homo sapiens_hsa05416	0.35268436
158	Phototransduction_Homo sapiens_hsa04744	0.33904279
159	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.33349123
160	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.33070298
161	Herpes simplex infection_Homo sapiens_hsa05168	0.32964538

DLX3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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