DLX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)7.76991026
2cilium movement (GO:0003341)6.61824257
3hair cycle (GO:0042633)6.53625884
4molting cycle (GO:0042303)6.53625884
5desmosome organization (GO:0002934)6.42777808
6hemidesmosome assembly (GO:0031581)5.89994361
7tooth mineralization (GO:0034505)5.80724636
8folic acid-containing compound biosynthetic process (GO:0009396)4.83617332
9epithelial cilium movement (GO:0003351)4.66697390
10ribosomal small subunit biogenesis (GO:0042274)4.56999293
11male meiosis I (GO:0007141)4.46205376
12GTP biosynthetic process (GO:0006183)4.45130419
13bundle of His cell to Purkinje myocyte communication (GO:0086069)4.40976500
14homocysteine metabolic process (GO:0050667)4.36390634
15UTP biosynthetic process (GO:0006228)4.36335671
16regulation of mesenchymal cell apoptotic process (GO:2001053)4.31820811
17heterochromatin organization (GO:0070828)4.28740628
18odontogenesis of dentin-containing tooth (GO:0042475)4.23241458
19otic vesicle formation (GO:0030916)4.22236427
20UTP metabolic process (GO:0046051)4.17032450
21hippo signaling (GO:0035329)4.16841127
22mitotic chromosome condensation (GO:0007076)4.15106863
23ribosome biogenesis (GO:0042254)4.12000003
24folic acid metabolic process (GO:0046655)4.10189903
25axonemal dynein complex assembly (GO:0070286)4.08272267
26paraxial mesoderm development (GO:0048339)4.07957857
27L-serine metabolic process (GO:0006563)4.00063884
28notochord development (GO:0030903)3.98824026
29positive regulation of meiotic cell cycle (GO:0051446)3.94131395
30ribonucleoprotein complex biogenesis (GO:0022613)3.91596170
31positive regulation of odontogenesis (GO:0042482)3.86289445
32hair follicle development (GO:0001942)3.83866781
33synaptonemal complex organization (GO:0070193)3.83315338
34galactose catabolic process (GO:0019388)3.81240320
35formation of translation preinitiation complex (GO:0001731)3.80918629
36DNA strand elongation involved in DNA replication (GO:0006271)3.80426974
37DNA replication initiation (GO:0006270)3.76890406
38brain morphogenesis (GO:0048854)3.74202999
39mitochondrial RNA metabolic process (GO:0000959)3.73034621
40positive regulation of meiosis (GO:0045836)3.71666093
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.71233986
42tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.71233986
43DNA strand elongation (GO:0022616)3.70311160
44pteridine-containing compound biosynthetic process (GO:0042559)3.69125994
45epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.67471566
46positive regulation of male gonad development (GO:2000020)3.66974670
47multicellular organismal aging (GO:0010259)3.64771533
48piRNA metabolic process (GO:0034587)3.63712102
49regulation of male gonad development (GO:2000018)3.59022575
50odontogenesis (GO:0042476)3.58625376
51negative regulation of chondrocyte differentiation (GO:0032331)3.56907278
52embryonic camera-type eye development (GO:0031076)3.56336311
53synaptonemal complex assembly (GO:0007130)3.56244381
54pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.54588355
55nucleoside diphosphate phosphorylation (GO:0006165)3.54489478
56DNA replication checkpoint (GO:0000076)3.54189449
57telomere maintenance via semi-conservative replication (GO:0032201)3.52623466
58neural crest cell development (GO:0014032)3.50320608
59limb bud formation (GO:0060174)3.50286731
60left/right axis specification (GO:0070986)3.48489968
61lateral sprouting from an epithelium (GO:0060601)3.47544913
62meiosis I (GO:0007127)3.46502789
63folic acid-containing compound metabolic process (GO:0006760)3.45634995
64tetrahydrofolate metabolic process (GO:0046653)3.44917743
65serine family amino acid biosynthetic process (GO:0009070)3.43206744
66regulation of translational fidelity (GO:0006450)3.41187206
67bone trabecula formation (GO:0060346)3.41150542
68glucocorticoid receptor signaling pathway (GO:0042921)3.37414720
69mitotic cell cycle arrest (GO:0071850)3.37212441
70molting cycle process (GO:0022404)3.36535516
71hair cycle process (GO:0022405)3.36535516
72head development (GO:0060322)3.36233895
73proline biosynthetic process (GO:0006561)3.35440448
74intermediate filament organization (GO:0045109)3.35147535
75motile cilium assembly (GO:0044458)3.34992559
76sulfur amino acid catabolic process (GO:0000098)3.34544220
77cilium or flagellum-dependent cell motility (GO:0001539)3.31341709
78regulation of glucose import in response to insulin stimulus (GO:2001273)3.31024074
79transcription from mitochondrial promoter (GO:0006390)3.30928775
80viral transcription (GO:0019083)3.30300019
81maturation of SSU-rRNA (GO:0030490)3.27946487
82regulation of mammary gland epithelial cell proliferation (GO:0033599)3.26921876
83microtubule bundle formation (GO:0001578)3.26231411
84regulation of mitochondrial translation (GO:0070129)3.26034192
85negative regulation of catenin import into nucleus (GO:0035414)3.22325799
86cellular protein complex localization (GO:0034629)3.20818089
87pseudouridine synthesis (GO:0001522)3.20478715
88basement membrane organization (GO:0071711)3.16620309
89translational termination (GO:0006415)3.16547803
90establishment of tissue polarity (GO:0007164)3.16494293
91establishment of planar polarity (GO:0001736)3.16494293
92craniofacial suture morphogenesis (GO:0097094)3.15685377
93regulation of hippo signaling (GO:0035330)3.13667812
94ribosomal large subunit biogenesis (GO:0042273)3.13041500
95regulation of heart morphogenesis (GO:2000826)3.12898476
96negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.12487554
97GDP-mannose metabolic process (GO:0019673)3.12333833
98epidermis development (GO:0008544)3.11528618
99purine nucleotide salvage (GO:0032261)3.10651872
100ribosomal small subunit assembly (GO:0000028)3.10202980
101chromosome condensation (GO:0030261)3.09968307
102endocardial cushion morphogenesis (GO:0003203)3.09602958
103keratinocyte differentiation (GO:0030216)3.07460837
104rRNA modification (GO:0000154)3.06877435
105DNA unwinding involved in DNA replication (GO:0006268)3.06670364
106planar cell polarity pathway involved in neural tube closure (GO:0090179)3.06225460
107renal filtration (GO:0097205)3.05615285
108regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.05471440
109deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.05174947
110pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.05032258
111rRNA processing (GO:0006364)3.04971358
112ventricular system development (GO:0021591)3.04810259
113pteridine-containing compound metabolic process (GO:0042558)3.01891857
114regulation of odontogenesis (GO:0042481)3.01799779
115blood vessel maturation (GO:0001955)3.01490599
116gap junction assembly (GO:0016264)2.99387716
117meiotic nuclear division (GO:0007126)2.97872578
118regulation of pigment cell differentiation (GO:0050932)2.97603079
119guanosine-containing compound biosynthetic process (GO:1901070)2.97472192
120lung-associated mesenchyme development (GO:0060484)2.97232922
121cellular component biogenesis (GO:0044085)2.97136035
122pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.96029801
123peptidyl-arginine omega-N-methylation (GO:0035247)2.95713631
124regulation of translational termination (GO:0006449)2.95310869
125protein complex localization (GO:0031503)2.95065386
126translational elongation (GO:0006414)2.94192441
127IMP biosynthetic process (GO:0006188)2.94116841
128mitotic sister chromatid cohesion (GO:0007064)2.92755310
129positive regulation of extracellular matrix organization (GO:1903055)2.92522443
130CTP metabolic process (GO:0046036)2.92289917
131CTP biosynthetic process (GO:0006241)2.92289917
132Golgi transport vesicle coating (GO:0048200)2.91345558
133COPI coating of Golgi vesicle (GO:0048205)2.91345558
134regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.91236822
135nephron tubule formation (GO:0072079)2.91133419
136mitotic sister chromatid segregation (GO:0000070)2.90873912
137cranial suture morphogenesis (GO:0060363)2.90435448
138pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.90321502
139pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.89536703
140wound healing, spreading of epidermal cells (GO:0035313)2.88538724
141cell surface receptor signaling pathway involved in heart development (GO:0061311)2.88225621
142protein heterotrimerization (GO:0070208)2.88086809
143embryonic cranial skeleton morphogenesis (GO:0048701)2.86988001
144male meiosis (GO:0007140)2.85815511
145viral mRNA export from host cell nucleus (GO:0046784)2.85799622
146purine nucleobase biosynthetic process (GO:0009113)2.84537289
147protein localization to chromosome, centromeric region (GO:0071459)2.84284644
148rRNA metabolic process (GO:0016072)2.84201805
149pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.84138924
150negative regulation of myoblast differentiation (GO:0045662)2.83419491
151nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.83085678
152regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.82490268
153positive regulation of developmental pigmentation (GO:0048087)2.82359013
154cysteine metabolic process (GO:0006534)2.82271362
155CENP-A containing nucleosome assembly (GO:0034080)2.81606381
156telomere maintenance via recombination (GO:0000722)2.79815140
157translational initiation (GO:0006413)2.78747145
158pyrimidine nucleotide catabolic process (GO:0006244)2.78111213
159nucleobase-containing small molecule interconversion (GO:0015949)2.77449708
160DNA packaging (GO:0006323)2.75952838
161nuclear pore complex assembly (GO:0051292)2.75893270
162virion attachment to host cell (GO:0019062)2.75625962
163adhesion of symbiont to host cell (GO:0044650)2.75625962
164mitotic recombination (GO:0006312)2.75534559
165regulation of cell fate specification (GO:0042659)2.75218288
166response to vitamin A (GO:0033189)2.75208608
167rRNA methylation (GO:0031167)2.74287071
168SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.73780742
169embryonic retina morphogenesis in camera-type eye (GO:0060059)2.73480333
170regulation of hair follicle development (GO:0051797)2.73392791
171mesenchymal cell development (GO:0014031)2.72856565
172negative regulation of epidermis development (GO:0045683)2.71723607
173epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71308593
174protein targeting to mitochondrion (GO:0006626)2.69802349
175galactose metabolic process (GO:0006012)2.67233123
176viral life cycle (GO:0019058)2.66587319
177proteasome assembly (GO:0043248)2.65927908
178protein maturation by protein folding (GO:0022417)2.65351036
179cotranslational protein targeting to membrane (GO:0006613)2.64039885
180protein targeting to ER (GO:0045047)2.62459610
181nucleobase biosynthetic process (GO:0046112)2.62265753
182ribosome assembly (GO:0042255)2.60607242
183tRNA methylation (GO:0030488)2.60367602
184GMP metabolic process (GO:0046037)2.60180227
185nucleotide salvage (GO:0043173)2.58832001
186proline metabolic process (GO:0006560)2.55031183
187chromatin remodeling at centromere (GO:0031055)2.54491513

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.85267020
2RBPJ_22232070_ChIP-Seq_NCS_Mouse6.08398931
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.61719810
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.75673894
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.60371128
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.44565211
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.21836108
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.07915555
9CLOCK_20551151_ChIP-Seq_293T_Human2.95027694
10E2F7_22180533_ChIP-Seq_HELA_Human2.83070811
11AR_21909140_ChIP-Seq_LNCAP_Human2.73579516
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72028852
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64244869
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60035382
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.56407509
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.53813574
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52919649
18XRN2_22483619_ChIP-Seq_HELA_Human2.52446859
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.42844351
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37268054
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.32016013
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.29428746
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.20415714
24SOX9_24532713_ChIP-Seq_HFSC_Mouse2.20101370
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18630912
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.13328856
27ETS1_20019798_ChIP-Seq_JURKAT_Human2.07358527
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05417917
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.02567922
30DCP1A_22483619_ChIP-Seq_HELA_Human2.01505179
31DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.97940826
32* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.94343486
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.93554150
34GATA1_22025678_ChIP-Seq_K562_Human1.93378216
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92289812
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91564733
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84372671
38* GABP_19822575_ChIP-Seq_HepG2_Human1.83145576
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.82814683
40ZNF263_19887448_ChIP-Seq_K562_Human1.77689502
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.76605264
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74652306
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73739508
44KLF4_18555785_ChIP-Seq_MESCs_Mouse1.73432260
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.71894864
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.70606372
47CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.69346638
48* TTF2_22483619_ChIP-Seq_HELA_Human1.69317483
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68604653
50CJUN_26792858_Chip-Seq_BT549_Human1.67329112
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64069303
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63757578
53P63_26484246_Chip-Seq_KERATINOCYTES_Human1.61907443
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61817055
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58877415
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58181322
57* TP53_20018659_ChIP-ChIP_R1E_Mouse1.57632746
58SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.56833180
59SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.56833180
60MYC_22102868_ChIP-Seq_BL_Human1.56252510
61KDM5A_27292631_Chip-Seq_BREAST_Human1.55923125
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54004492
63CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51744716
64VDR_21846776_ChIP-Seq_THP-1_Human1.51305650
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45753076
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45694163
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45445483
68* RACK7_27058665_Chip-Seq_MCF-7_Human1.42801922
69EST1_17652178_ChIP-ChIP_JURKAT_Human1.42340852
70SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.41930727
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.39177187
72TCF4_18268006_ChIP-ChIP_LS174T_Human1.39139499
73LXR_22292898_ChIP-Seq_THP-1_Human1.37588626
74TP53_18474530_ChIP-ChIP_U2OS_Human1.37318860
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35619977
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.34724223
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34688990
78CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.33110876
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31739474
80TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31087977
81CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30930472
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.30861367
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30663608
84RUNX1_27514584_Chip-Seq_MCF-7_Human1.28476615
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28451452
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27693593
87* KLF5_25053715_ChIP-Seq_YYC3_Human1.27572932
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26705169
89SALL1_21062744_ChIP-ChIP_HESCs_Human1.23889723
90FOXP3_21729870_ChIP-Seq_TREG_Human1.22145346
91NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21242804
92P68_20966046_ChIP-Seq_HELA_Human1.20615969
93WT1_19549856_ChIP-ChIP_CCG9911_Human1.20156275
94FOXO3_23340844_ChIP-Seq_DLD1_Human1.19209671
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19094484
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18593246
97MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18280995
98SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18219005
99STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18072135
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17794936
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16628919
102BCAT_22108803_ChIP-Seq_LS180_Human1.12927242
103YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12450137
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11957893
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11644247
106TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11083107
107CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10302652
108* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10026768
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08810131
110RING1B_27294783_Chip-Seq_NPCs_Mouse1.08792948
111TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08266488
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08253361
113E2F4_17652178_ChIP-ChIP_JURKAT_Human1.07917972
114TFEB_21752829_ChIP-Seq_HELA_Human1.07560800
115* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07015949
116CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06578602
117* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.06470424
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06293891
119SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05473999
120ELK3_25401928_ChIP-Seq_HUVEC_Human1.05222437
121STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.03364959
122YY1_21170310_ChIP-Seq_MESCs_Mouse1.02958708
123ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02581605
124ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02551657
125TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02429461
126HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01989402
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01867155
128CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01046444
129TP63_23658742_ChIP-Seq_EP156T_Human1.00590974
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00366860
131CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00327454
132SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00221952
133FOXP1_21924763_ChIP-Seq_HESCs_Human0.98117428
134HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98032157
135* GATA1_26923725_Chip-Seq_HPCs_Mouse0.97885137
136KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97669611
137GATA4_25053715_ChIP-Seq_YYC3_Human0.97597402
138ATF3_27146783_Chip-Seq_COLON_Human0.96857444
139NCOR1_26117541_ChIP-Seq_K562_Human0.96259412
140RXR_22108803_ChIP-Seq_LS180_Human0.96204871
141FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96066365
142* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95581647
143KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94942026
144SOX2_20726797_ChIP-Seq_SW620_Human0.94497073
145FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93408021
146ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92685572
147SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90187682
148ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.89494454
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89184340
150RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88877288
151* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87369297
152ISL1_27105846_Chip-Seq_CPCs_Mouse0.86657184
153NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86351783
154BRD4_25478319_ChIP-Seq_HGPS_Human0.84592764
155* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.84586017
156HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84252977
157* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84117105
158TCF4_22108803_ChIP-Seq_LS180_Human0.81941395
159* RING1B_27294783_Chip-Seq_ESCs_Mouse0.81790692
160ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81310483
161UBF1/2_26484160_Chip-Seq_HMECs_Human0.80726566
162FOXM1_26456572_ChIP-Seq_MCF-7_Human0.79266597
163ESR1_21235772_ChIP-Seq_MCF-7_Human0.77067051
164MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.75903432
165STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.74693042
166TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.73440829
167KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.71507406
168TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.71314277
169CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.70833733
170P300_27058665_Chip-Seq_ZR-75-30cells_Human0.70822496
171ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.70417626
172EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.70305524
173ERG_20517297_ChIP-Seq_VCAP_Human0.69779237
174PPARA_22158963_ChIP-Seq_LIVER_Mouse0.68728139
175EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.68394741
176SMAD4_21741376_ChIP-Seq_EPCs_Human0.68393930
177DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.68092242
178KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.67618028
179KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.67618028
180KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.67618028
181TP53_16413492_ChIP-PET_HCT116_Human0.66061958
182LXR_22158963_ChIP-Seq_LIVER_Mouse0.66037688
183ERG_21242973_ChIP-ChIP_JURKAT_Human0.65200760
184TP53_23651856_ChIP-Seq_MEFs_Mouse0.64674279

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000383_abnormal_hair_follicle4.31953606
2MP0003136_yellow_coat_color3.97854703
3MP0002254_reproductive_system_inflammat3.93423606
4MP0000579_abnormal_nail_morphology3.82376381
5MP0005275_abnormal_skin_tensile3.63019521
6MP0010678_abnormal_skin_adnexa3.58520807
7MP0000647_abnormal_sebaceous_gland3.47711298
8MP0003693_abnormal_embryo_hatching3.43950294
9MP0002796_impaired_skin_barrier3.20877527
10MP0002098_abnormal_vibrissa_morphology3.12818956
11MP0000566_synostosis2.89508089
12MP0000427_abnormal_hair_cycle2.79233005
13MP0003111_abnormal_nucleus_morphology2.76945693
14MP0003705_abnormal_hypodermis_morpholog2.75601371
15MP0004957_abnormal_blastocyst_morpholog2.75036227
16MP0004233_abnormal_muscle_weight2.65228282
17MP0010234_abnormal_vibrissa_follicle2.60629854
18MP0000377_abnormal_hair_follicle2.59555239
19MP0010094_abnormal_chromosome_stability2.52541710
20MP0002060_abnormal_skin_morphology2.49451224
21MP0010030_abnormal_orbit_morphology2.41519898
22MP0000678_abnormal_parathyroid_gland2.36792548
23MP0003077_abnormal_cell_cycle2.32014013
24MP0004381_abnormal_hair_follicle2.26297170
25MP0005670_abnormal_white_adipose2.17160508
26MP0008932_abnormal_embryonic_tissue2.14842763
27MP0005501_abnormal_skin_physiology2.13684198
28MP0005451_abnormal_body_composition2.07980219
29MP0001661_extended_life_span2.03698585
30MP0004264_abnormal_extraembryonic_tissu2.01352449
31MP0001216_abnormal_epidermal_layer1.99987051
32MP0008058_abnormal_DNA_repair1.99609925
33MP0003941_abnormal_skin_development1.99259990
34MP0002234_abnormal_pharynx_morphology1.95090349
35MP0000003_abnormal_adipose_tissue1.87707223
36MP0000762_abnormal_tongue_morphology1.87242436
37MP0003806_abnormal_nucleotide_metabolis1.87156469
38MP0004272_abnormal_basement_membrane1.86367868
39MP0010771_integument_phenotype1.84363707
40MP0005623_abnormal_meninges_morphology1.81596843
41MP0008438_abnormal_cutaneous_collagen1.81488652
42MP0002249_abnormal_larynx_morphology1.81144312
43MP0003937_abnormal_limbs/digits/tail_de1.80472810
44MP0001243_abnormal_dermal_layer1.80424193
45MP0001730_embryonic_growth_arrest1.77639855
46MP0003315_abnormal_perineum_morphology1.73115626
47MP0003453_abnormal_keratinocyte_physiol1.70850829
48MP0002160_abnormal_reproductive_system1.70532624
49MP0001849_ear_inflammation1.62195147
50MP0002938_white_spotting1.61495644
51MP0009053_abnormal_anal_canal1.59392112
52MP0009379_abnormal_foot_pigmentation1.58715828
53MP0000467_abnormal_esophagus_morphology1.50954443
54MP0002009_preneoplasia1.44820907
55MP0000537_abnormal_urethra_morphology1.42723510
56MP0000428_abnormal_craniofacial_morphol1.38661277
57MP0002653_abnormal_ependyma_morphology1.37172336
58MP0001697_abnormal_embryo_size1.36807028
59MP0000432_abnormal_head_morphology1.34595019
60MP0005058_abnormal_lysosome_morphology1.34146062
61MP0010307_abnormal_tumor_latency1.31950766
62MP0003279_aneurysm1.28735699
63MP0008995_early_reproductive_senescence1.27780304
64MP0002080_prenatal_lethality1.27270070
65MP0009333_abnormal_splenocyte_physiolog1.26291406
66MP0005666_abnormal_adipose_tissue1.26177083
67MP0001346_abnormal_lacrimal_gland1.25297703
68MP0001672_abnormal_embryogenesis/_devel1.24884394
69MP0005380_embryogenesis_phenotype1.24884394
70MP0002396_abnormal_hematopoietic_system1.24827131
71MP0001340_abnormal_eyelid_morphology1.20456358
72MP0003385_abnormal_body_wall1.20212883
73MP0005375_adipose_tissue_phenotype1.19138229
74MP0003755_abnormal_palate_morphology1.18616355
75MP0009250_abnormal_appendicular_skeleto1.17155421
76MP0005503_abnormal_tendon_morphology1.16840074
77MP0002282_abnormal_trachea_morphology1.16655911
78MP0001764_abnormal_homeostasis1.16630838
79MP0009697_abnormal_copulation1.16452367
80MP0003984_embryonic_growth_retardation1.14878963
81MP0000013_abnormal_adipose_tissue1.14618380
82MP0005646_abnormal_pituitary_gland1.12483651
83MP0003186_abnormal_redox_activity1.12105798
84MP0009672_abnormal_birth_weight1.11661925
85MP0010352_gastrointestinal_tract_polyps1.11591137
86MP0000516_abnormal_urinary_system1.10836515
87MP0005367_renal/urinary_system_phenotyp1.10836515
88MP0002111_abnormal_tail_morphology1.10541863
89MP0002088_abnormal_embryonic_growth/wei1.09963351
90MP0002932_abnormal_joint_morphology1.09674751
91MP0002086_abnormal_extraembryonic_tissu1.09654282
92MP0008260_abnormal_autophagy1.06970960
93MP0003935_abnormal_craniofacial_develop1.06528107
94MP0001851_eye_inflammation1.05001386
95MP0005409_darkened_coat_color1.04225964
96MP0003566_abnormal_cell_adhesion1.03250184
97MP0008877_abnormal_DNA_methylation1.03169526
98MP0003786_premature_aging1.03089951
99MP0005076_abnormal_cell_differentiation1.02021224
100MP0005397_hematopoietic_system_phenotyp1.01127601
101MP0001545_abnormal_hematopoietic_system1.01127601
102MP0003718_maternal_effect1.00116545
103MP0004808_abnormal_hematopoietic_stem1.00080921
104MP0000490_abnormal_crypts_of0.99567112
105MP0005083_abnormal_biliary_tract0.99227793
106MP0002085_abnormal_embryonic_tissue0.99183124
107MP0005408_hypopigmentation0.98905180
108MP0000313_abnormal_cell_death0.97977879
109MP0005187_abnormal_penis_morphology0.97729933
110MP0004782_abnormal_surfactant_physiolog0.96777370
111MP0000049_abnormal_middle_ear0.96400713
112MP0009384_cardiac_valve_regurgitation0.96185333
113MP0000358_abnormal_cell_content/0.94664436
114MP0005508_abnormal_skeleton_morphology0.93914032
115MP0000367_abnormal_coat/_hair0.92892491
116MP0002116_abnormal_craniofacial_bone0.92748429
117MP0005023_abnormal_wound_healing0.91898214
118MP0008057_abnormal_DNA_replication0.91441990
119MP0000681_abnormal_thyroid_gland0.91315140
120MP0008007_abnormal_cellular_replicative0.90859781
121MP0003878_abnormal_ear_physiology0.88754030
122MP0005377_hearing/vestibular/ear_phenot0.88754030
123MP0006035_abnormal_mitochondrial_morpho0.88125602
124MP0003123_paternal_imprinting0.87443262
125MP0001145_abnormal_male_reproductive0.85796942
126MP0004185_abnormal_adipocyte_glucose0.84382386
127MP0009931_abnormal_skin_appearance0.82969211
128MP0005389_reproductive_system_phenotype0.82369445
129MP0003936_abnormal_reproductive_system0.81431377
130MP0002896_abnormal_bone_mineralization0.80571334
131MP0002092_abnormal_eye_morphology0.80198872
132MP0001270_distended_abdomen0.78688226
133MP0000534_abnormal_ureter_morphology0.78481994
134MP0002233_abnormal_nose_morphology0.77570033
135MP0002877_abnormal_melanocyte_morpholog0.75950929
136MP0003115_abnormal_respiratory_system0.75882073
137MP0002109_abnormal_limb_morphology0.75156153
138MP0002210_abnormal_sex_determination0.75106000
139MP0001191_abnormal_skin_condition0.74686308
140MP0002115_abnormal_skeleton_extremities0.74075591
141MP0002697_abnormal_eye_size0.73290365
142MP0000538_abnormal_urinary_bladder0.73284240
143MP0004197_abnormal_fetal_growth/weight/0.71535672
144MP0000733_abnormal_muscle_development0.70726307
145MP0000462_abnormal_digestive_system0.70712371
146MP0004947_skin_inflammation0.70270786
147MP0000350_abnormal_cell_proliferation0.69409909
148MP0003942_abnormal_urinary_system0.68710702
149MP0002095_abnormal_skin_pigmentation0.68225446
150MP0000613_abnormal_salivary_gland0.67819402
151MP0003567_abnormal_fetal_cardiomyocyte0.65430602
152MP0000163_abnormal_cartilage_morphology0.65357137
153MP0002084_abnormal_developmental_patter0.64005311
154MP0003724_increased_susceptibility_to0.63637410
155MP0003890_abnormal_embryonic-extraembry0.61191311
156MP0000627_abnormal_mammary_gland0.59227511
157MP0001286_abnormal_eye_development0.57818288
158MP0002102_abnormal_ear_morphology0.57419086

Predicted human phenotypes

RankGene SetZ-score
1Amelogenesis imperfecta (HP:0000705)6.14469977
2Abnormal ciliary motility (HP:0012262)5.50215621
3Abnormal respiratory motile cilium physiology (HP:0012261)5.45802533
4Pili torti (HP:0003777)5.19131598
5Hypotrichosis (HP:0001006)4.89653238
6Woolly hair (HP:0002224)4.78927139
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.78040564
8Abnormality of alanine metabolism (HP:0010916)4.51264886
9Hyperalaninemia (HP:0003348)4.51264886
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.51264886
11Abnormality of the fetal cardiovascular system (HP:0010948)4.48473367
12Abnormal umbilical cord blood vessels (HP:0011403)4.48473367
13Single umbilical artery (HP:0001195)4.48473367
14Rhinitis (HP:0012384)4.33344327
15Fragile nails (HP:0001808)4.30657026
16Birth length less than 3rd percentile (HP:0003561)4.29312994
17Onycholysis (HP:0001806)4.09415452
18Milia (HP:0001056)4.08977022
19Neonatal short-limb short stature (HP:0008921)3.89165878
20Follicular hyperkeratosis (HP:0007502)3.67429171
21True hermaphroditism (HP:0010459)3.64762502
22Abnormality of the umbilical cord (HP:0010881)3.59616514
23Abnormal respiratory epithelium morphology (HP:0012253)3.51243691
24Abnormal respiratory motile cilium morphology (HP:0005938)3.51243691
25Atrophic scars (HP:0001075)3.46931520
26Natal tooth (HP:0000695)3.45759380
27Reticulocytopenia (HP:0001896)3.42700892
28Down-sloping shoulders (HP:0200021)3.35607240
29Chromosomal breakage induced by crosslinking agents (HP:0003221)3.33190274
30Progressive muscle weakness (HP:0003323)3.28755259
31Aplasia/Hypoplasia of the sacrum (HP:0008517)3.26946515
32Septate vagina (HP:0001153)3.13019665
33Shallow orbits (HP:0000586)3.10522852
34Nonprogressive disorder (HP:0003680)3.10101459
35Chromsome breakage (HP:0040012)3.04684604
36Abnormal hair laboratory examination (HP:0003328)3.03693873
37Bronchomalacia (HP:0002780)2.98563406
38Premature rupture of membranes (HP:0001788)2.96475681
39Selective tooth agenesis (HP:0001592)2.95304361
40Supernumerary spleens (HP:0009799)2.91924344
41Hypoparathyroidism (HP:0000829)2.90025085
42Pancreatic fibrosis (HP:0100732)2.87172998
43Fibular hypoplasia (HP:0003038)2.86000689
44Coronal craniosynostosis (HP:0004440)2.82161622
45Abnormality of the distal phalanges of the toes (HP:0010182)2.79350645
46Trismus (HP:0000211)2.71836377
47Right ventricular cardiomyopathy (HP:0011663)2.70358571
48Nail dystrophy (HP:0008404)2.67776346
49Abnormality of the 2nd finger (HP:0004100)2.62949769
50Abnormalities of placenta or umbilical cord (HP:0001194)2.62800269
51Abnormality of the parietal bone (HP:0002696)2.57737390
52Chronic bronchitis (HP:0004469)2.56694054
53Congenital, generalized hypertrichosis (HP:0004540)2.56430629
54Sex reversal (HP:0012245)2.56196524
55Abnormal sex determination (HP:0012244)2.56196524
56Protrusio acetabuli (HP:0003179)2.55133849
57Unilateral renal agenesis (HP:0000122)2.54519567
58Esophageal varix (HP:0002040)2.53581449
59Ragged-red muscle fibers (HP:0003200)2.53310357
60Abnormality of the phalanges of the hallux (HP:0010057)2.50270610
61Plantar hyperkeratosis (HP:0007556)2.49635647
62Microretrognathia (HP:0000308)2.48296990
63Ankle contracture (HP:0006466)2.47755455
64Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.46857532
65Hypochromic anemia (HP:0001931)2.46383025
66Constricted visual fields (HP:0001133)2.45085053
67Popliteal pterygium (HP:0009756)2.45043113
68Reduced subcutaneous adipose tissue (HP:0003758)2.43938669
69Concave nail (HP:0001598)2.42528451
70Truncus arteriosus (HP:0001660)2.41212543
71Advanced eruption of teeth (HP:0006288)2.40744023
72Abnormality of cells of the erythroid lineage (HP:0012130)2.38563701
73Blepharitis (HP:0000498)2.38520870
74Occipital encephalocele (HP:0002085)2.36322019
75Sparse eyelashes (HP:0000653)2.34085543
76Duplication of thumb phalanx (HP:0009942)2.34049445
7711 pairs of ribs (HP:0000878)2.31924962
78Hypergonadotropic hypogonadism (HP:0000815)2.30772877
79Abnormal connection of the cardiac segments (HP:0011545)2.28583791
80Abnormal ventriculo-arterial connection (HP:0011563)2.28583791
81Transposition of the great arteries (HP:0001669)2.28583791
82Breast hypoplasia (HP:0003187)2.26911848
83Hypodontia (HP:0000668)2.26896855
84Sparse lateral eyebrow (HP:0005338)2.25896075
85Abnormality of glycolysis (HP:0004366)2.24707620
86Hyperthyroidism (HP:0000836)2.24023575
87Bronchiectasis (HP:0002110)2.22825492
88Hypoplastic left heart (HP:0004383)2.21020898
89Abnormality of homocysteine metabolism (HP:0010919)2.19626673
90Homocystinuria (HP:0002156)2.19626673
91Macrocytic anemia (HP:0001972)2.17272229
92Aplasia cutis congenita (HP:0001057)2.17113282
93Congenital ichthyosiform erythroderma (HP:0007431)2.16814732
94Hypertensive crisis (HP:0100735)2.16549963
95Premature ovarian failure (HP:0008209)2.15361942
96Lip pit (HP:0100267)2.13459265
97Ridged nail (HP:0001807)2.12997683
98Abnormality of the tricuspid valve (HP:0001702)2.12735908
99Acanthosis nigricans (HP:0000956)2.12704379
100Absent/shortened dynein arms (HP:0200106)2.11940311
101Dynein arm defect of respiratory motile cilia (HP:0012255)2.11940311
102Increased serum pyruvate (HP:0003542)2.11205824
103Increased connective tissue (HP:0009025)2.09532671
104Abnormality of sulfur amino acid metabolism (HP:0004339)2.07824689
105Deviation of the thumb (HP:0009603)2.07151211
106Absent eyelashes (HP:0000561)2.05996355
107Testicular atrophy (HP:0000029)2.05870850
108Abnormal number of erythroid precursors (HP:0012131)2.04063924
109Abnormality of the middle phalanges of the toes (HP:0010183)2.03516936
110Facial cleft (HP:0002006)2.02726758
111Biconcave vertebral bodies (HP:0004586)2.01496466
112Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.00650913
113Short 4th metacarpal (HP:0010044)2.00650913
114Pallor (HP:0000980)2.00418993
115Microvesicular hepatic steatosis (HP:0001414)2.00335900
116Abnormality of the frontal sinuses (HP:0002687)2.00120115
117Osteolytic defects of the hand bones (HP:0009699)1.97554847
118Osteolytic defects of the phalanges of the hand (HP:0009771)1.97554847
119Broad distal phalanx of finger (HP:0009836)1.96534815
120Cortical visual impairment (HP:0100704)1.93867998
121Abnormal number of incisors (HP:0011064)1.93528293
122Absent radius (HP:0003974)1.93438768
123Alopecia of scalp (HP:0002293)1.93261230
124Villous atrophy (HP:0011473)1.92537717
125Abnormality of small intestinal villus morphology (HP:0011472)1.92537717
126Missing ribs (HP:0000921)1.92267430
127Increased nuchal translucency (HP:0010880)1.91887014
128Seborrheic dermatitis (HP:0001051)1.91826436
129Slow-growing hair (HP:0002217)1.91270982
130Abnormality of hair growth rate (HP:0011363)1.91270982
131Abnormality of subcutaneous fat tissue (HP:0001001)1.89575775
132Trigonocephaly (HP:0000243)1.88643084
133Abnormality of pyrimidine metabolism (HP:0004353)1.87659126
134Aplasia/Hypoplasia of the tongue (HP:0010295)1.86824857
135Oligodontia (HP:0000677)1.84107625
136Decreased subcutaneous fat (HP:0001002)1.83080755
137Myopathic facies (HP:0002058)1.83031017
138Preauricular skin tag (HP:0000384)1.82814289
139Nasal polyposis (HP:0100582)1.82584100
140Atresia of the external auditory canal (HP:0000413)1.82149271
141Absent thumb (HP:0009777)1.82080908
142Progressive external ophthalmoplegia (HP:0000590)1.81737601
143Spinal rigidity (HP:0003306)1.79788439
144Cystic liver disease (HP:0006706)1.79189147
145Abnormality of dental color (HP:0011073)1.78877796
146Fatigue (HP:0012378)1.78500436
147Hypokinesia (HP:0002375)1.78441943
148Aplasia/Hypoplasia of the fibula (HP:0006492)1.78020823
149Absent forearm bone (HP:0003953)1.77247629
150Aplasia involving forearm bones (HP:0009822)1.77247629
151Type I transferrin isoform profile (HP:0003642)1.77236848
152Esophageal neoplasm (HP:0100751)1.77198514
153Neoplasm of head and neck (HP:0012288)1.77198514
154Pterygium (HP:0001059)1.76945762
155Reduced antithrombin III activity (HP:0001976)1.76302232
156Abnormality of dentin (HP:0010299)1.75820560
157Chronic sinusitis (HP:0011109)1.75567910
158Hypoplastic labia majora (HP:0000059)1.75270559
159Short thumb (HP:0009778)1.75169858
160Median cleft lip (HP:0000161)1.75002309
161Rectal prolapse (HP:0002035)1.74604178
162Wormian bones (HP:0002645)1.72210645
163Increased serum lactate (HP:0002151)1.70854322
164Brittle hair (HP:0002299)1.66952623
165Abnormal vertebral ossification (HP:0100569)1.66713754
166Ureteral duplication (HP:0000073)1.66540989
167Gout (HP:0001997)1.66342019
168Abnormality of reticulocytes (HP:0004312)1.65653251
169Insomnia (HP:0100785)1.65593673
170Parakeratosis (HP:0001036)1.65352432
171Abnormality of the aortic arch (HP:0012303)1.64433917
172Pancreatic cysts (HP:0001737)1.63202421
173Humeroradial synostosis (HP:0003041)1.62519373
174Synostosis involving the elbow (HP:0003938)1.62519373
175Abnormal tarsal ossification (HP:0008369)1.62498082
176Hypoplastic heart (HP:0001961)1.61321658
177Squamous cell carcinoma (HP:0002860)1.61296444
178Proximal placement of thumb (HP:0009623)1.60769289
179Abnormality of carpal bone ossification (HP:0006257)1.60491912
180Flat acetabular roof (HP:0003180)1.60183190
181Abnormality of the preputium (HP:0100587)1.59921010
182Short hallux (HP:0010109)1.59054070
183Abnormality of the labia majora (HP:0012881)1.58844215
184Broad metatarsal (HP:0001783)1.57498400
185Abnormality of the hip-girdle musculature (HP:0001445)1.57094896
186Abnormality of the musculature of the pelvis (HP:0001469)1.57094896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.60199177
2LATS13.86660895
3PBK3.26051269
4MAP2K23.19480924
5PNCK3.00469299
6EEF2K2.96138414
7BUB12.87049771
8BRSK22.70330880
9NME12.59245453
10MAPK152.58014008
11DYRK32.47081765
12SMG12.43047926
13WEE12.32886576
14PDK22.31794332
15MST42.23392861
16LATS22.19107214
17NLK2.16813812
18MAP2K32.16710529
19MAP3K32.12524851
20FGFR22.11004044
21STK31.97425456
22ICK1.95190581
23RIPK11.94945090
24DAPK21.90863523
25EPHA21.90489157
26RPS6KB21.87532899
27EIF2AK11.80222385
28PDGFRA1.79854745
29STK38L1.72125314
30VRK21.69380935
31MAP3K21.68458017
32CDK71.65089957
33CDK91.63864702
34MAPKAPK31.63444038
35STK101.53576155
36FER1.52007524
37IRAK31.51686807
38MST1R1.50002459
39IRAK11.47655737
40CDC71.47238598
41ACVR1B1.43559716
42TESK21.42203971
43STK161.38443115
44CHEK21.33222539
45MAP2K11.30409543
46MET1.28666392
47RPS6KA41.27738424
48CDK121.25348003
49CDK81.18370503
50FLT31.15723482
51BMX1.14878414
52CSNK1G11.13560479
53DDR21.11765449
54PRPF4B1.09013837
55CDK61.08662740
56BRSK11.08300397
57NEK21.05091762
58TTK1.04699389
59CDK191.04098240
60CAMKK21.03525594
61FGFR11.02119304
62ATR1.01741198
63MAPKAPK51.00595791
64CHEK11.00344554
65SRPK10.98890263
66MAP3K110.96959901
67AURKA0.95750465
68AKT20.92315029
69MAPKAPK20.90681029
70TESK10.90425493
71CCNB10.89403219
72PTK60.89240490
73PAK40.87480711
74FRK0.87231176
75TRIB30.86979458
76PAK20.85375969
77SIK10.84592221
78ROCK10.84074416
79PLK20.83104742
80PTK20.82198381
81ILK0.81673316
82PKN20.81199472
83MAP3K100.80556343
84BCKDK0.80193142
85ABL20.79177617
86BRAF0.75929360
87PLK30.74375022
88ARAF0.73789829
89TRPM70.73496991
90CDK40.71704675
91PIM20.70852561
92LRRK20.70467064
93DYRK1A0.70296841
94TTN0.69484972
95DYRK1B0.69013092
96PDPK10.65100682
97BRD40.63930474
98MAP3K70.63105109
99CDK20.62601600
100PLK40.59873661
101WNK40.59585761
102NEK10.57458894
103CDK10.55859801
104GSK3A0.55274735
105TSSK60.52846724
106DAPK30.52401864
107PAK30.52385440
108AURKB0.52025121
109MOS0.51903378
110LIMK10.49521831
111STK40.48947358
112CSNK2A10.48567518
113SCYL20.44978427
114TLK10.44943714
115FGR0.44230052
116PDGFRB0.44192496
117RPS6KA20.43966804
118PRKCI0.43858586
119STK110.43605024
120PLK10.43547865
121ROCK20.41952767
122TGFBR20.40127942
123CSNK2A20.39403936
124ERN10.39128069
125TAOK20.38986611
126MTOR0.38840821
127DAPK10.38394065
128FGFR40.38231820
129JAK30.37076030
130CLK10.36634437
131TGFBR10.36620718
132IRAK20.36505157
133CSNK1E0.36441070
134ITK0.36286774
135MAPK90.35799862
136MAP3K80.35120259
137ATM0.34448821
138VRK10.33954289
139MAPK10.32758541
140KSR20.32745465
141TAOK10.32651109
142MAP3K60.31798611
143KDR0.30925849
144ERBB40.30800812
145NEK60.30239253
146SIK30.29364924
147CDK11A0.28814842
148MAPK110.27836690
149RPS6KA10.27538042
150ALK0.27141428
151EPHB20.26838121
152PAK10.26449886

Predicted pathways (KEGG)

RankGene SetZ-score
1Hedgehog signaling pathway_Homo sapiens_hsa043403.99376500
2Basal cell carcinoma_Homo sapiens_hsa052173.77579867
3One carbon pool by folate_Homo sapiens_hsa006703.19577100
4Histidine metabolism_Homo sapiens_hsa003403.19433245
5Sulfur relay system_Homo sapiens_hsa041223.17237416
6ECM-receptor interaction_Homo sapiens_hsa045123.07546033
7Hippo signaling pathway_Homo sapiens_hsa043902.84083833
8Base excision repair_Homo sapiens_hsa034102.65921225
9Bladder cancer_Homo sapiens_hsa052192.60652584
10Proteasome_Homo sapiens_hsa030502.56505576
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.44033263
12Cell cycle_Homo sapiens_hsa041102.24975718
13Tryptophan metabolism_Homo sapiens_hsa003802.18833458
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.18540301
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14486694
16Nucleotide excision repair_Homo sapiens_hsa034202.07180554
17Galactose metabolism_Homo sapiens_hsa000522.04020451
18Folate biosynthesis_Homo sapiens_hsa007902.03605567
19TGF-beta signaling pathway_Homo sapiens_hsa043501.96312371
20Pyrimidine metabolism_Homo sapiens_hsa002401.94998100
21RNA polymerase_Homo sapiens_hsa030201.86261866
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.85303252
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.83435364
24Proteoglycans in cancer_Homo sapiens_hsa052051.74816161
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.71653328
26Small cell lung cancer_Homo sapiens_hsa052221.69670333
27DNA replication_Homo sapiens_hsa030301.69443951
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.60614722
29Arginine biosynthesis_Homo sapiens_hsa002201.59069230
30Wnt signaling pathway_Homo sapiens_hsa043101.58878796
31Sulfur metabolism_Homo sapiens_hsa009201.54332981
32Notch signaling pathway_Homo sapiens_hsa043301.54038707
33p53 signaling pathway_Homo sapiens_hsa041151.53913892
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.53658437
35Focal adhesion_Homo sapiens_hsa045101.53322036
36Adherens junction_Homo sapiens_hsa045201.53223388
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.51391379
38PPAR signaling pathway_Homo sapiens_hsa033201.51032888
39MicroRNAs in cancer_Homo sapiens_hsa052061.45066687
40Retinol metabolism_Homo sapiens_hsa008301.43984500
41Pathways in cancer_Homo sapiens_hsa052001.43543035
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41714349
43Other glycan degradation_Homo sapiens_hsa005111.40137371
44Oxidative phosphorylation_Homo sapiens_hsa001901.39688274
45Selenocompound metabolism_Homo sapiens_hsa004501.38169678
46Chemical carcinogenesis_Homo sapiens_hsa052041.37555893
47Thyroid cancer_Homo sapiens_hsa052161.36212483
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.35477241
49HTLV-I infection_Homo sapiens_hsa051661.31472721
50Non-homologous end-joining_Homo sapiens_hsa034501.29970511
51Vibrio cholerae infection_Homo sapiens_hsa051101.29079201
52Carbon metabolism_Homo sapiens_hsa012001.23914691
53Collecting duct acid secretion_Homo sapiens_hsa049661.23709854
54Amoebiasis_Homo sapiens_hsa051461.22181103
55Pentose phosphate pathway_Homo sapiens_hsa000301.21628035
56Prostate cancer_Homo sapiens_hsa052151.20055153
57Ribosome_Homo sapiens_hsa030101.18102791
58Primary bile acid biosynthesis_Homo sapiens_hsa001201.14722842
59Phenylalanine metabolism_Homo sapiens_hsa003601.12052876
60Fructose and mannose metabolism_Homo sapiens_hsa000511.10146701
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08636814
62Huntingtons disease_Homo sapiens_hsa050161.08395457
63Fanconi anemia pathway_Homo sapiens_hsa034601.07418123
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05084139
65Vitamin B6 metabolism_Homo sapiens_hsa007501.04594130
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04004659
67Basal transcription factors_Homo sapiens_hsa030221.03890045
68Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03774805
69Parkinsons disease_Homo sapiens_hsa050121.01416078
70N-Glycan biosynthesis_Homo sapiens_hsa005100.99736518
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99229696
72Melanogenesis_Homo sapiens_hsa049160.95727255
73Melanoma_Homo sapiens_hsa052180.95470848
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95456144
75Tyrosine metabolism_Homo sapiens_hsa003500.93770193
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.93457721
77Purine metabolism_Homo sapiens_hsa002300.92211655
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89424516
79Dorso-ventral axis formation_Homo sapiens_hsa043200.87698344
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87132238
81Tight junction_Homo sapiens_hsa045300.86630619
82Mismatch repair_Homo sapiens_hsa034300.86211507
83Oocyte meiosis_Homo sapiens_hsa041140.83561189
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82667031
85Axon guidance_Homo sapiens_hsa043600.82289171
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80563158
87Pyruvate metabolism_Homo sapiens_hsa006200.80134593
88AMPK signaling pathway_Homo sapiens_hsa041520.79624588
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78961854
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77910263
91Glioma_Homo sapiens_hsa052140.77426878
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75492009
93Viral carcinogenesis_Homo sapiens_hsa052030.74870455
94Arginine and proline metabolism_Homo sapiens_hsa003300.72107589
95Estrogen signaling pathway_Homo sapiens_hsa049150.70338746
96Acute myeloid leukemia_Homo sapiens_hsa052210.67951099
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67803156
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67757424
99Viral myocarditis_Homo sapiens_hsa054160.67286260
100Endometrial cancer_Homo sapiens_hsa052130.66844528
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66409473
102Pancreatic cancer_Homo sapiens_hsa052120.66077713
103Nitrogen metabolism_Homo sapiens_hsa009100.65442016
104Chronic myeloid leukemia_Homo sapiens_hsa052200.64613688
105Biosynthesis of amino acids_Homo sapiens_hsa012300.63852194
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62830087
107Protein digestion and absorption_Homo sapiens_hsa049740.61789878
108Metabolic pathways_Homo sapiens_hsa011000.60274628
109Fatty acid elongation_Homo sapiens_hsa000620.60274589
110Caffeine metabolism_Homo sapiens_hsa002320.59943132
111Colorectal cancer_Homo sapiens_hsa052100.59510601
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56473667
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55387672
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53620690
115Alzheimers disease_Homo sapiens_hsa050100.52529360
116RNA transport_Homo sapiens_hsa030130.52175988
117mRNA surveillance pathway_Homo sapiens_hsa030150.52128078
118Lysine degradation_Homo sapiens_hsa003100.51867507
119FoxO signaling pathway_Homo sapiens_hsa040680.51354294
120Non-small cell lung cancer_Homo sapiens_hsa052230.50872089
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50380435
122Homologous recombination_Homo sapiens_hsa034400.49992880
123Glutathione metabolism_Homo sapiens_hsa004800.49640000
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.46945584
125Insulin resistance_Homo sapiens_hsa049310.46175335
126Spliceosome_Homo sapiens_hsa030400.46140518
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45909815
128Sphingolipid metabolism_Homo sapiens_hsa006000.45790193
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.43534392
130Fatty acid degradation_Homo sapiens_hsa000710.42587005
131Systemic lupus erythematosus_Homo sapiens_hsa053220.42160093
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41866166
133Apoptosis_Homo sapiens_hsa042100.41616436
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41252165
135Amphetamine addiction_Homo sapiens_hsa050310.40561013
136Vitamin digestion and absorption_Homo sapiens_hsa049770.39782470
137Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38863939
138Drug metabolism - other enzymes_Homo sapiens_hsa009830.38663519
139Gastric acid secretion_Homo sapiens_hsa049710.38472372
140Glucagon signaling pathway_Homo sapiens_hsa049220.38443142
141Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37915945
142RNA degradation_Homo sapiens_hsa030180.37875883
143Rap1 signaling pathway_Homo sapiens_hsa040150.36056098
144Fatty acid biosynthesis_Homo sapiens_hsa000610.34326292
145Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34282363
146Prion diseases_Homo sapiens_hsa050200.33868564
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32619408
148Complement and coagulation cascades_Homo sapiens_hsa046100.32503091
149cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31153551
150Epstein-Barr virus infection_Homo sapiens_hsa051690.30617330
151Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25532235
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24174743
153Steroid biosynthesis_Homo sapiens_hsa001000.23792183
154Fatty acid metabolism_Homo sapiens_hsa012120.19123764
155Synaptic vesicle cycle_Homo sapiens_hsa047210.18951847
156Lysosome_Homo sapiens_hsa041420.18305867
157Renal cell carcinoma_Homo sapiens_hsa052110.17918881

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