DLX5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of oligodendrocyte differentiation (GO:0048715)8.96326815
2pyrimidine nucleobase catabolic process (GO:0006208)6.50342854
3substrate-independent telencephalic tangential interneuron migration (GO:0021843)5.04023457
4substrate-independent telencephalic tangential migration (GO:0021826)5.04023457
5positive regulation of mitochondrial fission (GO:0090141)5.01297395
6nucleobase catabolic process (GO:0046113)4.96581834
7ear development (GO:0043583)4.88314754
8glycosphingolipid biosynthetic process (GO:0006688)4.81036583
9establishment of mitochondrion localization (GO:0051654)4.71197026
10neuron recognition (GO:0008038)4.66986042
11proximal/distal pattern formation (GO:0009954)4.64495556
12negative regulation of Notch signaling pathway (GO:0045746)4.62303383
13hippocampus development (GO:0021766)4.59884046
14protein-cofactor linkage (GO:0018065)4.58010920
15regulation of chemokine-mediated signaling pathway (GO:0070099)4.55698768
16limb bud formation (GO:0060174)4.55371432
17regulation of oligodendrocyte differentiation (GO:0048713)4.50689841
18dendritic spine morphogenesis (GO:0060997)4.50583513
19olfactory bulb development (GO:0021772)4.48168681
20eyelid development in camera-type eye (GO:0061029)4.42274425
21vocalization behavior (GO:0071625)4.35897347
22regulation of transcription involved in cell fate commitment (GO:0060850)4.33135128
23central nervous system projection neuron axonogenesis (GO:0021952)4.29750437
24negative regulation of glial cell differentiation (GO:0045686)4.22238614
25cornea development in camera-type eye (GO:0061303)4.20442134
26protein-DNA complex disassembly (GO:0032986)4.19677596
27nucleosome disassembly (GO:0006337)4.19677596
28negative regulation of translation, ncRNA-mediated (GO:0040033)4.02365637
29regulation of translation, ncRNA-mediated (GO:0045974)4.02365637
30negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.02365637
31auditory behavior (GO:0031223)4.01117626
32sequestering of actin monomers (GO:0042989)3.99128220
33neural tube formation (GO:0001841)3.88454876
34pyrimidine dimer repair (GO:0006290)3.86255379
35RNA localization (GO:0006403)3.81706487
36neuron cell-cell adhesion (GO:0007158)3.77065951
37neurotransmitter biosynthetic process (GO:0042136)3.76956917
38glycine transport (GO:0015816)3.72556210
39regulation of synaptic vesicle exocytosis (GO:2000300)3.67209576
40head development (GO:0060322)3.65689686
41L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.64659679
42presynaptic membrane assembly (GO:0097105)3.62342557
43axonal fasciculation (GO:0007413)3.58506362
44gamma-aminobutyric acid transport (GO:0015812)3.56915470
45calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.56664933
46cell proliferation in forebrain (GO:0021846)3.56196433
47negative chemotaxis (GO:0050919)3.55841256
48neuron fate commitment (GO:0048663)3.54664943
49succinate metabolic process (GO:0006105)3.53615601
50regulation of synapse structural plasticity (GO:0051823)3.52651066
51negative regulation of gliogenesis (GO:0014014)3.52084070
52spinal cord development (GO:0021510)3.52058454
53positive regulation of synapse assembly (GO:0051965)3.49254061
54cell migration in hindbrain (GO:0021535)3.49158703
55postsynaptic membrane organization (GO:0001941)3.47469709
56regulation of mitochondrial fission (GO:0090140)3.46343720
57ubiquinone metabolic process (GO:0006743)3.45128749
58sympathetic nervous system development (GO:0048485)3.41150772
59regulation of synaptic vesicle transport (GO:1902803)3.40282474
60neuronal action potential propagation (GO:0019227)3.37847582
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.37043464
62negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.36328268
63protein insertion into membrane (GO:0051205)3.35117017
64glial cell proliferation (GO:0014009)3.30826908
65forebrain neuron differentiation (GO:0021879)3.30511100
66ubiquinone biosynthetic process (GO:0006744)3.25763604
67synaptic vesicle maturation (GO:0016188)3.25211724
68regulation of short-term neuronal synaptic plasticity (GO:0048172)3.21345529
69mechanosensory behavior (GO:0007638)3.21042640
70positive regulation of amino acid transport (GO:0051957)3.20846586
71cell-cell junction maintenance (GO:0045217)3.19861056
72regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.19738811
73ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.19590918
74DNA integration (GO:0015074)3.15473674
75negative regulation of transcription regulatory region DNA binding (GO:2000678)3.15381875
76central nervous system neuron axonogenesis (GO:0021955)3.14681004
77C4-dicarboxylate transport (GO:0015740)3.13195531
78dosage compensation (GO:0007549)3.11741295
79DNA double-strand break processing (GO:0000729)3.11420722
80lung vasculature development (GO:0060426)3.10858206
81L-serine transport (GO:0015825)3.05489545
82negative regulation of dendrite development (GO:2000171)3.04513690
83response to pheromone (GO:0019236)3.04055775
84regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.02790098
85regulation of glutamate receptor signaling pathway (GO:1900449)3.00928984
86iron-sulfur cluster assembly (GO:0016226)3.00763899
87metallo-sulfur cluster assembly (GO:0031163)3.00763899
88response to dietary excess (GO:0002021)3.00530884
89regulation of long-term neuronal synaptic plasticity (GO:0048169)2.99686732
90cardiac ventricle formation (GO:0003211)2.99133410
91L-methionine salvage (GO:0071267)2.98244271
92L-methionine biosynthetic process (GO:0071265)2.98244271
93amino acid salvage (GO:0043102)2.98244271
94ribonucleoprotein complex disassembly (GO:0032988)2.98145243
95DNA damage response, detection of DNA damage (GO:0042769)2.97979300
96presynaptic membrane organization (GO:0097090)2.95943944
97regulation of development, heterochronic (GO:0040034)2.95809584
98dendritic spine organization (GO:0097061)2.94887995
99nonmotile primary cilium assembly (GO:0035058)2.94371904
100peptidyl-tyrosine autophosphorylation (GO:0038083)2.91626511
101protein localization to cilium (GO:0061512)2.89911965
102positive regulation of synapse maturation (GO:0090129)2.89828979
103protein deneddylation (GO:0000338)2.88807553
104positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.88134403
105mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.88134403
106cerebral cortex radially oriented cell migration (GO:0021799)2.88101104
107regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.88028528
108neurotransmitter metabolic process (GO:0042133)2.87200736
109protein localization to synapse (GO:0035418)2.86726359
110cullin deneddylation (GO:0010388)2.86352328
111ATP hydrolysis coupled proton transport (GO:0015991)2.83770456
112energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.83770456
113regulation of synapse maturation (GO:0090128)2.83024951
114negative regulation of telomere maintenance (GO:0032205)2.82718799
115negative regulation of synaptic transmission, GABAergic (GO:0032229)2.81823265
116glycolipid biosynthetic process (GO:0009247)2.80948888
117smooth muscle tissue development (GO:0048745)2.80573669
118cerebral cortex cell migration (GO:0021795)2.78734221
119intraciliary transport (GO:0042073)2.78730227
120regulation of neurotransmitter levels (GO:0001505)2.78482942
121startle response (GO:0001964)2.78046114
122organelle disassembly (GO:1903008)2.76652810
123regulation of synapse assembly (GO:0051963)2.76357257
124kidney morphogenesis (GO:0060993)2.75571419
125dendrite morphogenesis (GO:0048813)2.75295294
126regulation of neuronal synaptic plasticity (GO:0048168)2.74017121
127embryonic cranial skeleton morphogenesis (GO:0048701)2.73379003
128neurotransmitter secretion (GO:0007269)2.73116172
129regulation of NFAT protein import into nucleus (GO:0051532)2.70802957
130ionotropic glutamate receptor signaling pathway (GO:0035235)2.70540791
131digestive tract morphogenesis (GO:0048546)2.69515895
132G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.69315778
133establishment of tissue polarity (GO:0007164)2.68493235
134establishment of planar polarity (GO:0001736)2.68493235
135regulation of cilium movement (GO:0003352)2.68446828
136synaptic vesicle endocytosis (GO:0048488)2.68214718
137somite development (GO:0061053)2.68147105
138glutamine family amino acid catabolic process (GO:0009065)2.68109763
139regulation of vesicle fusion (GO:0031338)2.68104841
140cardiac chamber formation (GO:0003207)2.68012116
141regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.67059707
142lens morphogenesis in camera-type eye (GO:0002089)2.64599708
143response to auditory stimulus (GO:0010996)2.63228445
144homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.62829496
145synaptic vesicle exocytosis (GO:0016079)2.61744343
146cell junction maintenance (GO:0034331)2.58901020
147glycerophospholipid catabolic process (GO:0046475)2.58377816
148protein localization to microtubule cytoskeleton (GO:0072698)2.58115764
149cellular response to prostaglandin stimulus (GO:0071379)2.57449918
150synapse assembly (GO:0007416)2.56883922
151synaptic transmission, glutamatergic (GO:0035249)2.55013897
152dicarboxylic acid catabolic process (GO:0043649)2.54549989
153regulation of synaptic transmission, GABAergic (GO:0032228)2.52284950
154lateral sprouting from an epithelium (GO:0060601)2.49486629
155embryonic body morphogenesis (GO:0010172)2.49291112
156adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.48129724
157regulation of glycogen (starch) synthase activity (GO:2000465)2.47047520
158regulation of synapse organization (GO:0050807)2.46421253

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.76766339
2ZNF274_21170338_ChIP-Seq_K562_Hela4.31329788
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.87734485
4IGF1R_20145208_ChIP-Seq_DFB_Human3.73753090
5GBX2_23144817_ChIP-Seq_PC3_Human3.67017099
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.09489639
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.04190806
8TAF15_26573619_Chip-Seq_HEK293_Human2.87197635
9* EZH2_27304074_Chip-Seq_ESCs_Mouse2.78384048
10* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.75784915
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.72822696
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.70717251
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.68684281
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64834819
15* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63413194
16* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63413194
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.60886339
18* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.55233385
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54024953
20PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.50626615
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.49295172
22* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49003666
23* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32867951
24* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28424892
25* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28179681
26GABP_17652178_ChIP-ChIP_JURKAT_Human2.27349248
27* EZH2_27294783_Chip-Seq_ESCs_Mouse2.25731333
28* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23802760
29* RNF2_27304074_Chip-Seq_ESCs_Mouse2.22128717
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.08991018
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07934861
32* RNF2_27304074_Chip-Seq_NSC_Mouse1.98318959
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97200841
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91725298
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.91272570
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.89875563
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.86072676
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82395684
39* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80064368
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.79860999
41DROSHA_22980978_ChIP-Seq_HELA_Human1.79261669
42* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77234273
43* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77134863
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76229336
45REST_21632747_ChIP-Seq_MESCs_Mouse1.75559683
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73877462
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72317895
48AHR_22903824_ChIP-Seq_MCF-7_Human1.60062497
49* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.60035676
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.59832288
51* RARB_27405468_Chip-Seq_BRAIN_Mouse1.58285654
52GABP_19822575_ChIP-Seq_HepG2_Human1.57639349
53EWS_26573619_Chip-Seq_HEK293_Human1.56041018
54P300_19829295_ChIP-Seq_ESCs_Human1.54308987
55TCF4_18268006_ChIP-ChIP_LS174T_Human1.53819753
56CBP_20019798_ChIP-Seq_JUKART_Human1.51836303
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51836303
58VDR_22108803_ChIP-Seq_LS180_Human1.51791666
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.51210043
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49574312
61* RING1B_27294783_Chip-Seq_NPCs_Mouse1.47650696
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.45599663
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.43719635
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.42308232
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42162130
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.41978371
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41641034
68AR_21572438_ChIP-Seq_LNCaP_Human1.39173342
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39013493
70FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.38373086
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37946579
72VDR_23849224_ChIP-Seq_CD4+_Human1.37827522
73ELK1_19687146_ChIP-ChIP_HELA_Human1.37485945
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.35267417
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.35091379
76ISL1_27105846_Chip-Seq_CPCs_Mouse1.34975228
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32368744
78IRF1_19129219_ChIP-ChIP_H3396_Human1.32283034
79* TP53_20018659_ChIP-ChIP_R1E_Mouse1.32243030
80SMAD4_21799915_ChIP-Seq_A2780_Human1.30527074
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.30525809
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30279861
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28402908
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.28283476
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.28275747
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27120002
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25844072
88MYC_18940864_ChIP-ChIP_HL60_Human1.24946127
89THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24528516
90ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24019371
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23383535
92* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22805722
93CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.22434090
94* SOX2_16153702_ChIP-ChIP_HESCs_Human1.21175678
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20658914
96GATA1_26923725_Chip-Seq_HPCs_Mouse1.19988514
97* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19709179
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18992203
99CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18485760
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.17585551
101HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15160306
102SMAD4_21741376_ChIP-Seq_HESCs_Human1.14690949
103AR_25329375_ChIP-Seq_VCAP_Human1.14568337
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14486730
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13295215
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11838184
107WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11077456
108* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10901082
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09949640
110SOX2_21211035_ChIP-Seq_LN229_Gbm1.09935869
111TP53_22573176_ChIP-Seq_HFKS_Human1.08545288
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06031240
113* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05387655
114TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05228999
115FUS_26573619_Chip-Seq_HEK293_Human1.05150868
116STAT3_23295773_ChIP-Seq_U87_Human1.05037988
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03368427
118SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.03338621
119YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02606001
120PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02358145
121CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01696667
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01283223
123ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00155265
124SOX9_26525672_Chip-Seq_HEART_Mouse0.99855089
125NCOR_22424771_ChIP-Seq_293T_Human0.99246358
126ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99126988
127MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97661842
128GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95383129
129CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94911730
130P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94390396
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94311158
132YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93983544
133HTT_18923047_ChIP-ChIP_STHdh_Human0.93541085
134EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93353100
135RUNX2_22187159_ChIP-Seq_PCA_Human0.92865853
136* ER_23166858_ChIP-Seq_MCF-7_Human0.92360080
137TCF4_23295773_ChIP-Seq_U87_Human0.91800830
138CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90314303
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89719609
140SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89646851
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89048141
142AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88165915
143DCP1A_22483619_ChIP-Seq_HELA_Human0.86879114
144AR_19668381_ChIP-Seq_PC3_Human0.86573339
145UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86312915
146SMAD3_21741376_ChIP-Seq_ESCs_Human0.85988341
147ELK4_26923725_Chip-Seq_MESODERM_Mouse0.85647404
148TP53_18474530_ChIP-ChIP_U2OS_Human0.85520667
149ERA_21632823_ChIP-Seq_H3396_Human0.83986151
150RAC3_21632823_ChIP-Seq_H3396_Human0.83513494
151FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.83458452
152EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.83319598

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005646_abnormal_pituitary_gland3.86115511
2* MP0008789_abnormal_olfactory_epithelium3.81619822
3MP0010030_abnormal_orbit_morphology3.65789262
4* MP0005499_abnormal_olfactory_system3.55408848
5* MP0005394_taste/olfaction_phenotype3.55408848
6MP0000778_abnormal_nervous_system3.11274983
7* MP0000049_abnormal_middle_ear2.91844321
8MP0006292_abnormal_olfactory_placode2.90311320
9MP0004859_abnormal_synaptic_plasticity2.73016921
10MP0005645_abnormal_hypothalamus_physiol2.55409400
11MP0000013_abnormal_adipose_tissue2.45635769
12MP0003787_abnormal_imprinting2.43204777
13MP0001984_abnormal_olfaction2.42328466
14MP0005248_abnormal_Harderian_gland2.40816703
15* MP0001270_distended_abdomen2.39377717
16MP0000537_abnormal_urethra_morphology2.36472047
17MP0008995_early_reproductive_senescence2.30308923
18MP0002653_abnormal_ependyma_morphology2.26237513
19MP0003122_maternal_imprinting2.21456613
20MP0000566_synostosis2.19879737
21MP0001346_abnormal_lacrimal_gland2.17780792
22MP0001986_abnormal_taste_sensitivity2.08191764
23MP0006276_abnormal_autonomic_nervous1.98756774
24MP0003221_abnormal_cardiomyocyte_apopto1.97241883
25MP0001502_abnormal_circadian_rhythm1.96233564
26MP0002736_abnormal_nociception_after1.93831094
27MP0001188_hyperpigmentation1.93647208
28MP0003635_abnormal_synaptic_transmissio1.90761808
29MP0003385_abnormal_body_wall1.88606754
30* MP0003755_abnormal_palate_morphology1.84020301
31MP0002063_abnormal_learning/memory/cond1.81237568
32MP0009046_muscle_twitch1.80945145
33MP0005084_abnormal_gallbladder_morpholo1.72920264
34MP0009745_abnormal_behavioral_response1.70170059
35MP0008877_abnormal_DNA_methylation1.70129392
36MP0004142_abnormal_muscle_tone1.70025907
37MP0009053_abnormal_anal_canal1.69305609
38MP0003880_abnormal_central_pattern1.66805294
39MP0002064_seizures1.63031695
40MP0004811_abnormal_neuron_physiology1.61815595
41MP0004134_abnormal_chest_morphology1.61614252
42* MP0002557_abnormal_social/conspecific_i1.57354758
43MP0002822_catalepsy1.54441258
44* MP0002184_abnormal_innervation1.54227622
45MP0005367_renal/urinary_system_phenotyp1.50898444
46MP0000516_abnormal_urinary_system1.50898444
47MP0002638_abnormal_pupillary_reflex1.50583078
48* MP0002116_abnormal_craniofacial_bone1.49012426
49MP0001905_abnormal_dopamine_level1.49009159
50MP0009250_abnormal_appendicular_skeleto1.48147184
51MP0005257_abnormal_intraocular_pressure1.47554579
52MP0003121_genomic_imprinting1.45612235
53MP0002909_abnormal_adrenal_gland1.45069356
54MP0004858_abnormal_nervous_system1.43421745
55MP0001529_abnormal_vocalization1.42984189
56* MP0002233_abnormal_nose_morphology1.41466030
57MP0002572_abnormal_emotion/affect_behav1.39901450
58MP0002272_abnormal_nervous_system1.39322510
59MP0000631_abnormal_neuroendocrine_gland1.38998136
60* MP0003861_abnormal_nervous_system1.38406354
61* MP0003935_abnormal_craniofacial_develop1.37996945
62MP0002751_abnormal_autonomic_nervous1.37544878
63MP0000678_abnormal_parathyroid_gland1.36866742
64MP0000955_abnormal_spinal_cord1.32922729
65MP0002009_preneoplasia1.22127851
66MP0005253_abnormal_eye_physiology1.20499382
67* MP0002882_abnormal_neuron_morphology1.19952187
68MP0005187_abnormal_penis_morphology1.18795331
69MP0004270_analgesia1.17915583
70* MP0003938_abnormal_ear_development1.15580873
71MP0000751_myopathy1.15306193
72* MP0002152_abnormal_brain_morphology1.14856963
73MP0002837_dystrophic_cardiac_calcinosis1.13526610
74MP0001486_abnormal_startle_reflex1.12083391
75MP0003942_abnormal_urinary_system1.10976895
76MP0005423_abnormal_somatic_nervous1.08183221
77MP0004133_heterotaxia1.07099516
78MP0005551_abnormal_eye_electrophysiolog1.06444745
79MP0002876_abnormal_thyroid_physiology1.05765012
80MP0002734_abnormal_mechanical_nocicepti1.05664276
81MP0001177_atelectasis1.05466084
82MP0000534_abnormal_ureter_morphology1.04328989
83MP0003119_abnormal_digestive_system1.03104392
84MP0004043_abnormal_pH_regulation1.02739856
85* MP0002081_perinatal_lethality1.01926538
86MP0002735_abnormal_chemical_nociception1.01490102
87MP0009780_abnormal_chondrocyte_physiolo0.97860367
88MP0003011_delayed_dark_adaptation0.97663855
89MP0006035_abnormal_mitochondrial_morpho0.97537287
90* MP0003937_abnormal_limbs/digits/tail_de0.97530215
91* MP0000026_abnormal_inner_ear0.97520927
92MP0008058_abnormal_DNA_repair0.93800362
93MP0002282_abnormal_trachea_morphology0.93328614
94* MP0000163_abnormal_cartilage_morphology0.92272934
95MP0001485_abnormal_pinna_reflex0.91501281
96MP0000647_abnormal_sebaceous_gland0.90798468
97MP0000750_abnormal_muscle_regeneration0.90744586
98MP0000372_irregular_coat_pigmentation0.89324677
99* MP0002177_abnormal_outer_ear0.88995797
100MP0003646_muscle_fatigue0.88891043
101* MP0002752_abnormal_somatic_nervous0.87710542
102* MP0003115_abnormal_respiratory_system0.85639951
103MP0002102_abnormal_ear_morphology0.84790551
104* MP0002066_abnormal_motor_capabilities/c0.84730619
105MP0001963_abnormal_hearing_physiology0.84396291
106MP0003137_abnormal_impulse_conducting0.83318471
107MP0004885_abnormal_endolymph0.82994988
108MP0003315_abnormal_perineum_morphology0.82382646
109MP0003890_abnormal_embryonic-extraembry0.82373851
110* MP0002249_abnormal_larynx_morphology0.81341012
111MP0002067_abnormal_sensory_capabilities0.81263432
112MP0004924_abnormal_behavior0.80343010
113MP0005386_behavior/neurological_phenoty0.80343010
114MP0002896_abnormal_bone_mineralization0.79966762
115MP0004085_abnormal_heartbeat0.79964971
116MP0000467_abnormal_esophagus_morphology0.79324717
117MP0000681_abnormal_thyroid_gland0.79133055
118* MP0002069_abnormal_eating/drinking_beha0.78590712
119MP0002733_abnormal_thermal_nociception0.78204023
120MP0000428_abnormal_craniofacial_morphol0.77870049
121* MP0000432_abnormal_head_morphology0.77424081
122MP0003698_abnormal_male_reproductive0.77134515
123MP0003786_premature_aging0.77121148
124MP0001968_abnormal_touch/_nociception0.76562095
125MP0001501_abnormal_sleep_pattern0.75715402
126MP0001970_abnormal_pain_threshold0.75427756
127MP0002234_abnormal_pharynx_morphology0.74540971
128MP0005171_absent_coat_pigmentation0.74460306
129MP0003183_abnormal_peptide_metabolism0.74298872
130MP0004742_abnormal_vestibular_system0.73118629
131* MP0002098_abnormal_vibrissa_morphology0.72116571
132MP0002229_neurodegeneration0.71854500
133MP0006072_abnormal_retinal_apoptosis0.71630788
134* MP0001943_abnormal_respiration0.70956433
135MP0001764_abnormal_homeostasis0.70842820
136* MP0002109_abnormal_limb_morphology0.70755319
137MP0009697_abnormal_copulation0.69516092

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the aortic arch (HP:0012303)4.82558481
2Cortical dysplasia (HP:0002539)3.90169744
3Absent speech (HP:0001344)3.87608955
4Failure to thrive in infancy (HP:0001531)3.62433426
5Wrist flexion contracture (HP:0001239)3.50819552
6Lissencephaly (HP:0001339)3.50772435
7Thyroid-stimulating hormone excess (HP:0002925)3.46086797
8Retinal dysplasia (HP:0007973)3.42331701
9Large eyes (HP:0001090)3.30912482
10Limb dystonia (HP:0002451)3.26808817
11Bilateral microphthalmos (HP:0007633)3.19200092
12Abnormality of the intervertebral disk (HP:0005108)3.15450907
13Medial flaring of the eyebrow (HP:0010747)3.12710057
14Trigonocephaly (HP:0000243)3.12113364
15Papillary thyroid carcinoma (HP:0002895)3.04196504
16Inability to walk (HP:0002540)3.00676878
17Urinary urgency (HP:0000012)2.98968854
18Abnormality of the nasal septum (HP:0000419)2.96218733
19Focal motor seizures (HP:0011153)2.92498818
20Megalencephaly (HP:0001355)2.91589686
21Palpebral edema (HP:0100540)2.91498655
22Morphological abnormality of the middle ear (HP:0008609)2.84871255
23Febrile seizures (HP:0002373)2.73981067
24Hyperventilation (HP:0002883)2.73245300
25Ankle clonus (HP:0011448)2.72398104
26Specific learning disability (HP:0001328)2.65039283
27Progressive sensorineural hearing impairment (HP:0000408)2.60889015
28Abnormality of the metopic suture (HP:0005556)2.60532254
29Amyotrophic lateral sclerosis (HP:0007354)2.59663547
30Hip dysplasia (HP:0001385)2.57921446
31Hepatoblastoma (HP:0002884)2.56258661
32Fibular aplasia (HP:0002990)2.55258060
33Long clavicles (HP:0000890)2.51867526
34Nephrogenic diabetes insipidus (HP:0009806)2.51852105
35Patellar aplasia (HP:0006443)2.51377003
36Progressive inability to walk (HP:0002505)2.49326572
37Hypoplasia of the uterus (HP:0000013)2.48599284
38Peripheral hypomyelination (HP:0007182)2.48077906
39Conjugated hyperbilirubinemia (HP:0002908)2.46538592
40Amblyopia (HP:0000646)2.45308508
41Hypoplasia of the brainstem (HP:0002365)2.43595995
42Aplasia/Hypoplasia of the brainstem (HP:0007362)2.43595995
43Focal seizures (HP:0007359)2.42764470
44Polyphagia (HP:0002591)2.41361156
45Broad alveolar ridges (HP:0000187)2.39623515
46Oligodontia (HP:0000677)2.38879118
47Pancreatic cysts (HP:0001737)2.38574958
48Aplasia/Hypoplasia of the patella (HP:0006498)2.38301625
49* Split foot (HP:0001839)2.38055556
50Progressive cerebellar ataxia (HP:0002073)2.36467174
51Abnormal hair whorl (HP:0010721)2.35240398
52Oligodactyly (hands) (HP:0001180)2.33715915
53Epileptic encephalopathy (HP:0200134)2.33191333
54Neonatal respiratory distress (HP:0002643)2.32363517
55Aplasia/hypoplasia of the uterus (HP:0008684)2.30934187
56Pheochromocytoma (HP:0002666)2.29679221
57Intellectual disability, moderate (HP:0002342)2.29478796
58Pachygyria (HP:0001302)2.28774974
59Humeroradial synostosis (HP:0003041)2.27178499
60Synostosis involving the elbow (HP:0003938)2.27178499
61Anophthalmia (HP:0000528)2.25908898
62Annular pancreas (HP:0001734)2.25637407
63Micropenis (HP:0000054)2.25319303
64Abnormality of the hip-girdle musculature (HP:0001445)2.24885512
65Vaginal atresia (HP:0000148)2.23887477
66Pendular nystagmus (HP:0012043)2.23563768
67Type II lissencephaly (HP:0007260)2.22519942
68Genital tract atresia (HP:0001827)2.21877348
69Exotropia (HP:0000577)2.21504171
70Spastic gait (HP:0002064)2.20688875
71Sleep apnea (HP:0010535)2.19363159
72Hypsarrhythmia (HP:0002521)2.19101773
73Prominent supraorbital ridges (HP:0000336)2.18693200
74Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.16823220
75Prominent metopic ridge (HP:0005487)2.16615352
76Abnormality of the anterior horn cell (HP:0006802)2.13789642
77Degeneration of anterior horn cells (HP:0002398)2.13789642
78Broad-based gait (HP:0002136)2.12748219
79Polymicrogyria (HP:0002126)2.12633372
80EEG with generalized epileptiform discharges (HP:0011198)2.12159532
81Abnormality of the pubic bones (HP:0003172)2.11516649
82Abnormality of the labia minora (HP:0012880)2.09459260
83Optic nerve coloboma (HP:0000588)2.08499292
84Epileptiform EEG discharges (HP:0011182)2.08314939
85Slow-growing hair (HP:0002217)2.08298650
86Abnormality of hair growth rate (HP:0011363)2.08298650
87Atonic seizures (HP:0010819)2.07903367
88Truncus arteriosus (HP:0001660)2.06940853
89Intellectual disability, severe (HP:0010864)2.04725110
90Abnormal drinking behavior (HP:0030082)2.04722719
91Polydipsia (HP:0001959)2.04722719
92Hypomagnesemia (HP:0002917)2.04021020
93Decreased testicular size (HP:0008734)2.02740910
94Narrow nasal bridge (HP:0000446)1.99454381
95Optic nerve hypoplasia (HP:0000609)1.98546829
96Shoulder girdle muscle weakness (HP:0003547)1.95149921
97Open mouth (HP:0000194)1.94714015
98Septo-optic dysplasia (HP:0100842)1.94697322
99Muscular hypotonia of the trunk (HP:0008936)1.94667408
100Hypoplasia of the corpus callosum (HP:0002079)1.94142694
101Protruding tongue (HP:0010808)1.93218931
102Genetic anticipation (HP:0003743)1.92956602
103Acute necrotizing encephalopathy (HP:0006965)1.92714984
104Rimmed vacuoles (HP:0003805)1.92698204
105Heterochromia iridis (HP:0001100)1.92262874
106Hydroureter (HP:0000072)1.89928597
107Poor coordination (HP:0002370)1.89782229
108Increased number of teeth (HP:0011069)1.88414179
109Thyroid carcinoma (HP:0002890)1.87282906
110Renal hypoplasia (HP:0000089)1.86598458
111Progressive hearing impairment (HP:0001730)1.86104389
112Abnormality of salivation (HP:0100755)1.84639666
113Agitation (HP:0000713)1.83788283
114Tetany (HP:0001281)1.83450222
115Spina bifida occulta (HP:0003298)1.82498136
116Cupped ear (HP:0000378)1.82177121
117True hermaphroditism (HP:0010459)1.81531339
118Hyperthyroidism (HP:0000836)1.81312545
119Dyskinesia (HP:0100660)1.81289344
120Vitreoretinal degeneration (HP:0000655)1.81200514
121Renal dysplasia (HP:0000110)1.80318881
122Gait imbalance (HP:0002141)1.80120032
123Hypothermia (HP:0002045)1.79974551
124Oligodactyly (HP:0012165)1.79550654
125Abnormal mitochondria in muscle tissue (HP:0008316)1.79546189
126Adactyly (HP:0009776)1.79120090
127Abnormal pancreas size (HP:0012094)1.78841421
128Hypoplastic nipples (HP:0002557)1.78705406
129Myokymia (HP:0002411)1.76709048
130Widely spaced teeth (HP:0000687)1.76560424
131Tubulointerstitial nephritis (HP:0001970)1.76372997
1323-Methylglutaconic aciduria (HP:0003535)1.75498127
133Overlapping toe (HP:0001845)1.75353205
134Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.73744150
135Neuroendocrine neoplasm (HP:0100634)1.73206898
136Pancreatic fibrosis (HP:0100732)1.73161295
137Small hand (HP:0200055)1.71773087
138Short foot (HP:0001773)1.71592280
139Spastic tetraplegia (HP:0002510)1.71284448
140Labial hypoplasia (HP:0000066)1.70479012
141Esotropia (HP:0000565)1.70396151
142Spastic diplegia (HP:0001264)1.69381111
143Pelvic girdle muscle weakness (HP:0003749)1.69253709
144Bilateral sensorineural hearing impairment (HP:0008619)1.69099093
145Dialeptic seizures (HP:0011146)1.66370311
146Tracheomalacia (HP:0002779)1.66296104
147Nephronophthisis (HP:0000090)1.65651328
148Periorbital edema (HP:0100539)1.64941604
149Drooling (HP:0002307)1.64717301
150Excessive salivation (HP:0003781)1.64717301
151Progressive microcephaly (HP:0000253)1.64631790
152Decreased activity of mitochondrial respiratory chain (HP:0008972)1.64548183
153Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.64548183
154Focal dystonia (HP:0004373)1.63836481
155Atrophy/Degeneration involving motor neurons (HP:0007373)1.63091567
156Wide anterior fontanel (HP:0000260)1.62361912
157Congenital primary aphakia (HP:0007707)1.61613731
158Atelectasis (HP:0100750)1.61022320
159Short philtrum (HP:0000322)1.60591902
160Pointed chin (HP:0000307)1.60314801
161Scrotal hypoplasia (HP:0000046)1.59874087
162Long palpebral fissure (HP:0000637)1.59402826
163Abnormality of the musculature of the pelvis (HP:0001469)1.58510286

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.86131943
2CCNB13.44459760
3EPHB23.29327412
4CASK3.18210171
5MAP4K22.95261877
6TRIM282.93712266
7MAP3K122.82889426
8SRPK12.79030022
9EPHA32.50766117
10PINK12.48358685
11ERBB32.43607090
12SGK22.21824423
13MAP2K72.15109617
14SGK2232.14410223
15SGK4942.14410223
16PRPF4B2.12969447
17MAP3K42.01009028
18BMPR1B1.99723494
19NEK61.94639506
20DYRK21.87865273
21MKNK21.84862844
22SIK31.82485232
23STK38L1.81891103
24AKT31.70084491
25WNK31.69544107
26UHMK11.69536813
27MKNK11.67068734
28ICK1.65011556
29MAPK131.62492079
30KSR11.60248241
31ERBB41.54752023
32RPS6KA41.51171334
33CDK191.50014313
34MAP3K61.48859214
35ROCK11.44676097
36YES11.42464380
37NTRK21.41121430
38SGK31.37471879
39RPS6KA21.31095726
40EPHA41.23196020
41MINK11.20788544
42MARK21.13864009
43PRKCG1.13519022
44BCR1.12122211
45TSSK61.11901384
46MAP2K41.11295267
47PAK61.10276807
48NTRK31.03781969
49STK381.02314469
50LIMK11.02227485
51SIK21.01163557
52ADRBK10.99171945
53CAMK40.98263633
54ROCK20.98103124
55BCKDK0.97987861
56TAOK30.91279805
57EIF2AK10.91151000
58TESK10.88388368
59RPS6KA50.88231427
60FRK0.88043254
61CDK80.87492207
62MAP3K100.84793441
63PLK20.84302032
64MAP3K50.84175699
65PAK30.81900063
66TESK20.81323636
67MAPKAPK30.81024490
68NME10.80528939
69CDK50.79806837
70DDR20.79428872
71ADRBK20.79042866
72DYRK1B0.78691826
73DYRK1A0.76244287
74EPHA20.74882895
75TGFBR10.72727182
76CSNK1G20.72179131
77CSNK1A1L0.71145967
78PRKCE0.70844039
79DMPK0.69641193
80FER0.69638685
81TNIK0.68784395
82SGK10.67208998
83TAOK10.66468716
84CAMK2B0.66447379
85CSNK1G30.65823884
86ACVR1B0.64908369
87PKN10.62806576
88MAP2K10.62309431
89LATS20.61890022
90INSRR0.61577275
91BRD40.60459963
92OXSR10.57820219
93ERBB20.57182670
94MAP3K70.56610438
95HIPK20.56286275
96BRAF0.54354831
97GRK10.54254625
98ZAK0.53387626
99CDK11A0.52746273
100PDK20.52057716
101PIM20.51688984
102DAPK20.48963538
103RPS6KL10.48956884
104RPS6KC10.48956884
105NEK10.48532745
106CDK150.47082765
107MAPK80.45390929
108PRKAA10.44494870
109CAMK2A0.44434676
110CAMK2G0.44347637
111CSNK1A10.44280978
112CSNK1D0.43534362
113CDK180.43481419
114CAMKK20.42741414
115MAPK90.42070653
116PRKACA0.42015725
117PRKCZ0.41627957
118CSNK1G10.41598868
119TNK20.41002610
120PLK30.40533844
121RPS6KA10.40493157
122LATS10.39673156
123DAPK10.39174604
124GSK3B0.37917808
125PRKACB0.37734261
126MYLK0.37713217
127DYRK30.37405472
128CSNK1E0.37050856
129PRKD30.35255229
130PRKCB0.34709706
131CDK140.34495609
132IRAK20.34123030
133BMPR20.34030223
134VRK10.29062021
135PRKD10.28396439
136PRKCI0.27830255
137ABL10.27667098
138STK390.27199667
139TLK10.25242538
140AURKA0.21653294
141PRKACG0.21417414
142PRKD20.19756238
143CAMK2D0.19743818
144PRKDC0.19493753

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.33157167
2Nicotine addiction_Homo sapiens_hsa050333.16008406
3Synaptic vesicle cycle_Homo sapiens_hsa047213.15115312
4Collecting duct acid secretion_Homo sapiens_hsa049663.01313191
5Axon guidance_Homo sapiens_hsa043602.99472346
6GABAergic synapse_Homo sapiens_hsa047272.67746723
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45846606
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22944092
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.18454048
10Olfactory transduction_Homo sapiens_hsa047402.16702292
11Morphine addiction_Homo sapiens_hsa050322.15114185
12Vibrio cholerae infection_Homo sapiens_hsa051102.08411236
13Basal transcription factors_Homo sapiens_hsa030221.87651783
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.85399058
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.81524555
16Cocaine addiction_Homo sapiens_hsa050301.80439889
17Circadian entrainment_Homo sapiens_hsa047131.79079123
18Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.78550851
19Glutamatergic synapse_Homo sapiens_hsa047241.78478039
20Dopaminergic synapse_Homo sapiens_hsa047281.61215971
21Colorectal cancer_Homo sapiens_hsa052101.60595405
22Serotonergic synapse_Homo sapiens_hsa047261.58331689
23Butanoate metabolism_Homo sapiens_hsa006501.54873611
24Protein export_Homo sapiens_hsa030601.53584046
25Phagosome_Homo sapiens_hsa041451.52859682
26Cholinergic synapse_Homo sapiens_hsa047251.45310550
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43682199
28Circadian rhythm_Homo sapiens_hsa047101.42523511
29RNA polymerase_Homo sapiens_hsa030201.40300608
30Gap junction_Homo sapiens_hsa045401.38966523
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.38898685
32Endometrial cancer_Homo sapiens_hsa052131.29009210
33Basal cell carcinoma_Homo sapiens_hsa052171.26368582
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.26150995
35Wnt signaling pathway_Homo sapiens_hsa043101.25857036
36Hippo signaling pathway_Homo sapiens_hsa043901.25276917
37Long-term depression_Homo sapiens_hsa047301.23071322
38Taste transduction_Homo sapiens_hsa047421.20887024
39* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17185740
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16619091
41Caffeine metabolism_Homo sapiens_hsa002321.16579367
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.12904384
43Selenocompound metabolism_Homo sapiens_hsa004501.12747367
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11828226
45Regulation of autophagy_Homo sapiens_hsa041401.11642925
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09760324
47Amphetamine addiction_Homo sapiens_hsa050311.07357297
48Oxidative phosphorylation_Homo sapiens_hsa001901.06982559
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04829591
50ErbB signaling pathway_Homo sapiens_hsa040120.99317264
51Type I diabetes mellitus_Homo sapiens_hsa049400.95998126
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95319987
53Shigellosis_Homo sapiens_hsa051310.93845822
54beta-Alanine metabolism_Homo sapiens_hsa004100.92535774
55Ether lipid metabolism_Homo sapiens_hsa005650.90218749
56Hedgehog signaling pathway_Homo sapiens_hsa043400.90144536
57Alcoholism_Homo sapiens_hsa050340.89202579
58Melanoma_Homo sapiens_hsa052180.88913782
59Notch signaling pathway_Homo sapiens_hsa043300.87151971
60Oxytocin signaling pathway_Homo sapiens_hsa049210.86183774
61Parkinsons disease_Homo sapiens_hsa050120.84268959
62Rheumatoid arthritis_Homo sapiens_hsa053230.82836900
63Insulin secretion_Homo sapiens_hsa049110.81336050
64Linoleic acid metabolism_Homo sapiens_hsa005910.80449818
65Long-term potentiation_Homo sapiens_hsa047200.79982570
66Melanogenesis_Homo sapiens_hsa049160.79340992
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78899201
68MAPK signaling pathway_Homo sapiens_hsa040100.78517401
69Phototransduction_Homo sapiens_hsa047440.78511148
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77721021
71Spliceosome_Homo sapiens_hsa030400.77716979
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.77208121
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76687315
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75915650
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75070361
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74802430
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73426210
78Gastric acid secretion_Homo sapiens_hsa049710.70733589
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70120975
80Peroxisome_Homo sapiens_hsa041460.69653295
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69398552
82Estrogen signaling pathway_Homo sapiens_hsa049150.68702755
83Renal cell carcinoma_Homo sapiens_hsa052110.68072431
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67820587
85Salivary secretion_Homo sapiens_hsa049700.66486630
86FoxO signaling pathway_Homo sapiens_hsa040680.66074643
87RNA degradation_Homo sapiens_hsa030180.64939860
88Type II diabetes mellitus_Homo sapiens_hsa049300.63360469
89Adherens junction_Homo sapiens_hsa045200.63298170
90Cardiac muscle contraction_Homo sapiens_hsa042600.62059417
91Dilated cardiomyopathy_Homo sapiens_hsa054140.61230513
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60037705
93Tight junction_Homo sapiens_hsa045300.59480140
94mRNA surveillance pathway_Homo sapiens_hsa030150.59420219
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58656341
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57540045
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56465851
98Glioma_Homo sapiens_hsa052140.55546693
99Prostate cancer_Homo sapiens_hsa052150.53905318
100MicroRNAs in cancer_Homo sapiens_hsa052060.53112766
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53110482
102Huntingtons disease_Homo sapiens_hsa050160.52917422
103Rap1 signaling pathway_Homo sapiens_hsa040150.52595520
104Arginine and proline metabolism_Homo sapiens_hsa003300.52300785
105Calcium signaling pathway_Homo sapiens_hsa040200.50764051
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50410116
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49942066
108Ras signaling pathway_Homo sapiens_hsa040140.49073613
109Fanconi anemia pathway_Homo sapiens_hsa034600.48885115
110cAMP signaling pathway_Homo sapiens_hsa040240.48335531
111RNA transport_Homo sapiens_hsa030130.48268378
112Chemical carcinogenesis_Homo sapiens_hsa052040.47950130
113Oocyte meiosis_Homo sapiens_hsa041140.47176593
114AMPK signaling pathway_Homo sapiens_hsa041520.46018115
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45087734
116Renin secretion_Homo sapiens_hsa049240.44640799
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44517399
118Metabolic pathways_Homo sapiens_hsa011000.43470415
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42899762
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42794830
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42274947
122Sphingolipid metabolism_Homo sapiens_hsa006000.40174880
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40163668
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39208720
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37929135
126GnRH signaling pathway_Homo sapiens_hsa049120.37913445
127Vitamin B6 metabolism_Homo sapiens_hsa007500.37824622
128Alzheimers disease_Homo sapiens_hsa050100.37512749
129Focal adhesion_Homo sapiens_hsa045100.36894314
130Salmonella infection_Homo sapiens_hsa051320.36301071
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35771390
132Steroid biosynthesis_Homo sapiens_hsa001000.35539020
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35273379
134Primary bile acid biosynthesis_Homo sapiens_hsa001200.34588625
135Retinol metabolism_Homo sapiens_hsa008300.34546555
136Base excision repair_Homo sapiens_hsa034100.33669775
137Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33562447
138Sulfur relay system_Homo sapiens_hsa041220.33186031
139Prolactin signaling pathway_Homo sapiens_hsa049170.32119472
140Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31567238
141Fatty acid elongation_Homo sapiens_hsa000620.30778876
142ABC transporters_Homo sapiens_hsa020100.30186774
143Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27528698
144Proteasome_Homo sapiens_hsa030500.25619249
145Cysteine and methionine metabolism_Homo sapiens_hsa002700.22845163
146Phenylalanine metabolism_Homo sapiens_hsa003600.20224810

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