DMC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.33526637
2kinetochore organization (GO:0051383)5.19232973
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.17643506
4kinetochore assembly (GO:0051382)5.13176971
5piRNA metabolic process (GO:0034587)4.89638792
6mitotic metaphase plate congression (GO:0007080)4.79151655
7L-fucose catabolic process (GO:0042355)4.77190828
8fucose catabolic process (GO:0019317)4.77190828
9L-fucose metabolic process (GO:0042354)4.77190828
10DNA replication checkpoint (GO:0000076)4.75279429
11DNA replication initiation (GO:0006270)4.52266870
12DNA strand elongation involved in DNA replication (GO:0006271)4.42555921
13metaphase plate congression (GO:0051310)4.42091779
14synaptonemal complex assembly (GO:0007130)4.25883418
15DNA unwinding involved in DNA replication (GO:0006268)4.25535047
16response to pheromone (GO:0019236)4.25245647
17heterochromatin organization (GO:0070828)4.24771626
18purine nucleobase biosynthetic process (GO:0009113)4.21684903
19DNA strand elongation (GO:0022616)4.21388080
20nuclear pore organization (GO:0006999)4.20442583
21nucleobase biosynthetic process (GO:0046112)4.10191053
22DNA methylation involved in gamete generation (GO:0043046)4.10106596
23telomere maintenance via semi-conservative replication (GO:0032201)4.05568572
24attachment of spindle microtubules to kinetochore (GO:0008608)4.04649201
25regulation of meiosis I (GO:0060631)3.97827470
26kynurenine metabolic process (GO:0070189)3.95279474
27protein localization to kinetochore (GO:0034501)3.94708609
28synaptonemal complex organization (GO:0070193)3.87194936
29nuclear pore complex assembly (GO:0051292)3.86985473
30indolalkylamine catabolic process (GO:0046218)3.85191896
31tryptophan catabolic process (GO:0006569)3.85191896
32indole-containing compound catabolic process (GO:0042436)3.85191896
33chromatin remodeling at centromere (GO:0031055)3.84865339
34formation of translation preinitiation complex (GO:0001731)3.83288237
35resolution of meiotic recombination intermediates (GO:0000712)3.79472608
36indolalkylamine metabolic process (GO:0006586)3.77787992
37DNA replication-dependent nucleosome organization (GO:0034723)3.77045804
38DNA replication-dependent nucleosome assembly (GO:0006335)3.77045804
39establishment of chromosome localization (GO:0051303)3.75743208
40telomere maintenance via recombination (GO:0000722)3.73624949
41respiratory chain complex IV assembly (GO:0008535)3.72612599
42regulation of nuclear cell cycle DNA replication (GO:0033262)3.71577659
43somatic diversification of immune receptors via somatic mutation (GO:0002566)3.69619419
44somatic hypermutation of immunoglobulin genes (GO:0016446)3.69619419
45CENP-A containing nucleosome assembly (GO:0034080)3.69047862
46* meiotic nuclear division (GO:0007126)3.68283721
47negative regulation of chromosome segregation (GO:0051985)3.68144778
48mitotic recombination (GO:0006312)3.67028873
49spindle checkpoint (GO:0031577)3.64442392
50ribosome assembly (GO:0042255)3.64374594
51negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.64224095
52negative regulation of sister chromatid segregation (GO:0033046)3.64224095
53negative regulation of mitotic sister chromatid separation (GO:2000816)3.64224095
54negative regulation of mitotic sister chromatid segregation (GO:0033048)3.64224095
55mitotic nuclear envelope disassembly (GO:0007077)3.63611189
56tryptophan metabolic process (GO:0006568)3.62878960
57mitotic spindle assembly checkpoint (GO:0007094)3.62153303
58protein complex biogenesis (GO:0070271)3.62095668
59spindle assembly checkpoint (GO:0071173)3.61933975
60mitotic spindle checkpoint (GO:0071174)3.59979310
61protein K6-linked ubiquitination (GO:0085020)3.58956300
62DNA replication-independent nucleosome assembly (GO:0006336)3.57043753
63DNA replication-independent nucleosome organization (GO:0034724)3.57043753
64mitotic sister chromatid segregation (GO:0000070)3.56698518
65histone exchange (GO:0043486)3.54498374
66negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.54324624
67male meiosis (GO:0007140)3.53709831
68regulation of mitotic metaphase/anaphase transition (GO:0030071)3.52619904
69mitochondrial respiratory chain complex I assembly (GO:0032981)3.52506965
70NADH dehydrogenase complex assembly (GO:0010257)3.52506965
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.52506965
72nucleotide-excision repair, DNA gap filling (GO:0006297)3.52269633
73cornea development in camera-type eye (GO:0061303)3.52045407
74regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.50861344
75protein localization to chromosome, centromeric region (GO:0071459)3.47910339
76regulation of helicase activity (GO:0051095)3.47232147
77regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.45234044
78regulation of chromosome segregation (GO:0051983)3.44919156
79regulation of gene silencing by RNA (GO:0060966)3.44396559
80regulation of posttranscriptional gene silencing (GO:0060147)3.44396559
81regulation of gene silencing by miRNA (GO:0060964)3.44396559
82mismatch repair (GO:0006298)3.43893473
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.43538907
84telomere maintenance via telomere lengthening (GO:0010833)3.43161599
85* chromosome organization involved in meiosis (GO:0070192)3.42171456
86maturation of SSU-rRNA (GO:0030490)3.41042954
87microtubule depolymerization (GO:0007019)3.39605328
88membrane disassembly (GO:0030397)3.39362395
89nuclear envelope disassembly (GO:0051081)3.39362395
90cytochrome complex assembly (GO:0017004)3.38964005
91mitochondrial respiratory chain complex assembly (GO:0033108)3.37456973
92meiotic chromosome segregation (GO:0045132)3.35758705
93IMP biosynthetic process (GO:0006188)3.34939880
94regulation of sister chromatid segregation (GO:0033045)3.33997021
95regulation of mitotic sister chromatid separation (GO:0010965)3.33997021
96regulation of mitotic sister chromatid segregation (GO:0033047)3.33997021
97regulation of spindle organization (GO:0090224)3.33139302
98mitotic chromosome condensation (GO:0007076)3.32792395
99ribosome biogenesis (GO:0042254)3.29705525
100regulation of double-strand break repair via homologous recombination (GO:0010569)3.28464947
101* meiotic cell cycle process (GO:1903046)3.26583683
102water-soluble vitamin biosynthetic process (GO:0042364)3.26476608
103negative regulation of telomere maintenance (GO:0032205)3.25167082
104replication fork processing (GO:0031297)3.23892060
105DNA double-strand break processing (GO:0000729)3.23727679
106cellular ketone body metabolic process (GO:0046950)3.22796405
107sister chromatid segregation (GO:0000819)3.20659888
108regulation of histone H3-K9 methylation (GO:0051570)3.16404073
109regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.13508507
110chromosome segregation (GO:0007059)3.11837222
111ATP-dependent chromatin remodeling (GO:0043044)3.10295081
112* meiosis I (GO:0007127)3.10187121
113DNA damage response, detection of DNA damage (GO:0042769)3.09338533
114regulation of double-strand break repair (GO:2000779)3.07483277
115regulation of action potential (GO:0098900)3.07025172
116detection of light stimulus involved in sensory perception (GO:0050962)3.06614686
117detection of light stimulus involved in visual perception (GO:0050908)3.06614686
118DNA synthesis involved in DNA repair (GO:0000731)3.05431491
119transcription-coupled nucleotide-excision repair (GO:0006283)3.04409961
120postreplication repair (GO:0006301)3.04177866
121negative regulation of meiosis (GO:0045835)3.04150178
122pore complex assembly (GO:0046931)3.04090027
123platelet dense granule organization (GO:0060155)3.03880149
124indole-containing compound metabolic process (GO:0042430)3.02881977
125DNA deamination (GO:0045006)3.01421743
126anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.01284997
127positive regulation of chromosome segregation (GO:0051984)3.01227115
128regulation of hexokinase activity (GO:1903299)3.00192700
129regulation of glucokinase activity (GO:0033131)3.00192700
130* reciprocal meiotic recombination (GO:0007131)2.99997138
131* reciprocal DNA recombination (GO:0035825)2.99997138
132chromatin assembly or disassembly (GO:0006333)2.99072218
133establishment of protein localization to mitochondrial membrane (GO:0090151)2.94572882
134recombinational repair (GO:0000725)2.94382340
135double-strand break repair via homologous recombination (GO:0000724)2.92873403
136dopamine transport (GO:0015872)2.92212877
137ketone body metabolic process (GO:1902224)2.91932987
138energy coupled proton transport, down electrochemical gradient (GO:0015985)2.90217170
139ATP synthesis coupled proton transport (GO:0015986)2.90217170
140positive regulation of defense response to virus by host (GO:0002230)2.89838417
141pseudouridine synthesis (GO:0001522)2.87710029
142protein-cofactor linkage (GO:0018065)2.85528100
143protein neddylation (GO:0045116)2.84828417
144neuronal action potential (GO:0019228)2.84105387
145mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.81964308
146nonmotile primary cilium assembly (GO:0035058)2.81099068
147nucleoside transmembrane transport (GO:1901642)2.80583535
148protein polyglutamylation (GO:0018095)2.75991525
149epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.73146630
150regulation of cilium movement (GO:0003352)2.72673273
151regulation of memory T cell differentiation (GO:0043380)2.72535088
152nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.70869607
153sulfation (GO:0051923)2.70767722
154tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.68914616
155RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.68914616
156amine catabolic process (GO:0009310)2.68168014
157cellular biogenic amine catabolic process (GO:0042402)2.68168014
158exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66847007
159epithelial cilium movement (GO:0003351)2.66531147
160regulation of rhodopsin mediated signaling pathway (GO:0022400)2.65789112
161axoneme assembly (GO:0035082)2.60130979
162ubiquinone biosynthetic process (GO:0006744)2.59279061
163ubiquinone metabolic process (GO:0006743)2.57527261
164rhodopsin mediated signaling pathway (GO:0016056)2.57455049
165retinal cone cell development (GO:0046549)2.56900620
166reflex (GO:0060004)2.54297127
167synaptic transmission, cholinergic (GO:0007271)2.53308524
168negative regulation of mast cell activation (GO:0033004)2.53049985
169kidney morphogenesis (GO:0060993)2.52860117
170gamma-aminobutyric acid transport (GO:0015812)2.52486548
171negative regulation of DNA-dependent DNA replication (GO:2000104)2.52244504
172rRNA catabolic process (GO:0016075)2.51523272
173cilium morphogenesis (GO:0060271)2.49857063
174photoreceptor cell development (GO:0042461)2.46649484
175preassembly of GPI anchor in ER membrane (GO:0016254)2.46622963
176protein localization to cilium (GO:0061512)2.46622189
177serotonin metabolic process (GO:0042428)2.46432639
178phosphatidylinositol acyl-chain remodeling (GO:0036149)2.45325103
179negative regulation of transcription regulatory region DNA binding (GO:2000678)2.45095020
180mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.44919835
181RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.44517989
182multicellular organism reproduction (GO:0032504)2.43879127
183primary amino compound metabolic process (GO:1901160)2.43565794
184chaperone-mediated protein transport (GO:0072321)2.42266950
185mannosylation (GO:0097502)2.41823851
186nephron tubule morphogenesis (GO:0072078)2.41354784
187nephron epithelium morphogenesis (GO:0072088)2.41354784
188tRNA processing (GO:0008033)2.40087536
189L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.39928437
190intracellular protein transmembrane import (GO:0044743)2.36082927

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.99413156
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.75005110
3ZNF274_21170338_ChIP-Seq_K562_Hela4.10750482
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.90144494
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.80361705
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.52927709
7VDR_22108803_ChIP-Seq_LS180_Human3.52044487
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.26367485
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.17946479
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.02159772
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.86417827
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.85665775
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.79993990
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71163234
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.69067371
16GBX2_23144817_ChIP-Seq_PC3_Human2.68222381
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.61092446
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53499448
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.52658853
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.51958166
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51514682
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.46588533
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.45746210
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45287012
25IGF1R_20145208_ChIP-Seq_DFB_Human2.38090976
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.37831690
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.33463692
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32482890
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.28419261
30EWS_26573619_Chip-Seq_HEK293_Human2.25158584
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24439205
32GABP_17652178_ChIP-ChIP_JURKAT_Human2.20416490
33POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19111610
34FUS_26573619_Chip-Seq_HEK293_Human2.19071435
35AR_21909140_ChIP-Seq_LNCAP_Human2.18898955
36ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18873596
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.10636316
38E2F1_21310950_ChIP-Seq_MCF-7_Human2.08581078
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08020077
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.03608486
41EZH2_22144423_ChIP-Seq_EOC_Human2.03001777
42MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02210226
43CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01335400
44XRN2_22483619_ChIP-Seq_HELA_Human1.98535765
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.97549246
46KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.97549246
47KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.97549246
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.95431314
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94246194
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.91876350
51VDR_23849224_ChIP-Seq_CD4+_Human1.90747043
52TAF15_26573619_Chip-Seq_HEK293_Human1.90022422
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.86931253
54P300_19829295_ChIP-Seq_ESCs_Human1.85746436
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84399586
56NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.81872657
57DCP1A_22483619_ChIP-Seq_HELA_Human1.81512038
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79580563
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78130273
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.77016605
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.76952779
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76876368
63ER_23166858_ChIP-Seq_MCF-7_Human1.72523316
64TP53_22573176_ChIP-Seq_HFKS_Human1.71295033
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69027578
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67431783
67FOXP3_21729870_ChIP-Seq_TREG_Human1.63775806
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.63616657
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63208392
70GABP_19822575_ChIP-Seq_HepG2_Human1.62509004
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.60828192
72IRF1_19129219_ChIP-ChIP_H3396_Human1.59924807
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56683378
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.53770006
75KDM5A_27292631_Chip-Seq_BREAST_Human1.53379511
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.53133662
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52081012
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52046686
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49216090
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48239560
81TTF2_22483619_ChIP-Seq_HELA_Human1.47440180
82CIITA_25753668_ChIP-Seq_RAJI_Human1.46136327
83SOX2_19829295_ChIP-Seq_ESCs_Human1.45940527
84NANOG_19829295_ChIP-Seq_ESCs_Human1.45940527
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45364832
86BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44355307
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44267385
88CBP_20019798_ChIP-Seq_JUKART_Human1.44267385
89FOXA1_25329375_ChIP-Seq_VCAP_Human1.42904656
90FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42904656
91BCAT_22108803_ChIP-Seq_LS180_Human1.39587512
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37212676
93TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36027070
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34960861
95GATA3_21878914_ChIP-Seq_MCF-7_Human1.34389484
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34259699
97STAT3_23295773_ChIP-Seq_U87_Human1.33043376
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33035934
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32103130
100* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.30994720
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30109961
102AR_25329375_ChIP-Seq_VCAP_Human1.28377268
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27140570
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26389495
105POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26385537
106NFE2_27457419_Chip-Seq_LIVER_Mouse1.26253957
107TCF4_23295773_ChIP-Seq_U87_Human1.26134381
108* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26084153
109NCOR_22424771_ChIP-Seq_293T_Human1.25050912
110FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24607092
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24119361
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24119361
113SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23393707
114FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23320984
115TP63_19390658_ChIP-ChIP_HaCaT_Human1.23192936
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23161387
117KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22808617
118TCF3_18692474_ChIP-Seq_MESCs_Mouse1.22326381
119PIAS1_25552417_ChIP-Seq_VCAP_Human1.22308211
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.22231902
121CBX2_27304074_Chip-Seq_ESCs_Mouse1.21895411
122AR_20517297_ChIP-Seq_VCAP_Human1.21380006
123SMAD4_21799915_ChIP-Seq_A2780_Human1.21327020
124ELK1_19687146_ChIP-ChIP_HELA_Human1.21237097
125E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19448824
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19267347
127TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17992121
128TCF4_22108803_ChIP-Seq_LS180_Human1.17874308
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16408589
130ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16169576
131NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.15021451
132HOXB7_26014856_ChIP-Seq_BT474_Human1.14646423
133KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14290179
134SMAD4_21741376_ChIP-Seq_EPCs_Human1.13190527
135REST_21632747_ChIP-Seq_MESCs_Mouse1.12938361
136CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12576919
137NANOG_21062744_ChIP-ChIP_HESCs_Human1.12363124
138SMAD3_21741376_ChIP-Seq_EPCs_Human1.11551274
139CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11533881
140PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11406201
141EGR1_19374776_ChIP-ChIP_THP-1_Human1.11281548
142AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10937221
143SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09439649
144EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08479661
145KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07490659
146ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06184839
147RUNX2_22187159_ChIP-Seq_PCA_Human1.05356986
148CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04878345
149EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04272735
150SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02803736
151PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02625246
152CRX_20693478_ChIP-Seq_RETINA_Mouse1.02392021
153ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02194367
154RNF2_27304074_Chip-Seq_NSC_Mouse1.02016873
155TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01877869
156CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00702945
157ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98972356
158FOXH1_21741376_ChIP-Seq_EPCs_Human0.98567915
159ERA_21632823_ChIP-Seq_H3396_Human0.98434698
160HTT_18923047_ChIP-ChIP_STHdh_Human0.98386192
161FLI1_21867929_ChIP-Seq_TH2_Mouse0.98255626
162MYC_19829295_ChIP-Seq_ESCs_Human0.98061275
163HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97601135
164SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96686544
165NANOG_20526341_ChIP-Seq_ESCs_Human0.96254617
166* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96135410
167CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96023248
168STAT3_18555785_Chip-Seq_ESCs_Mouse0.93806838
169TFEB_21752829_ChIP-Seq_HELA_Human0.92428918
170* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92057956
171SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.91762929
172SOX2_18692474_ChIP-Seq_MESCs_Mouse0.91671737
173PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91051505
174POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90206633
175DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89015911
176* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.88730060
177MYC_22102868_ChIP-Seq_BL_Human0.88031914
178SRF_21415370_ChIP-Seq_HL-1_Mouse0.87872649
179NANOG_18692474_ChIP-Seq_MEFs_Mouse0.87493237
180MYC_18940864_ChIP-ChIP_HL60_Human0.86133424
181CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85786546
182SOX17_20123909_ChIP-Seq_XEN_Mouse0.85243439
183ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83819968
184NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.82860142

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting5.22927683
2MP0008877_abnormal_DNA_methylation5.03532234
3MP0010094_abnormal_chromosome_stability4.86995598
4MP0003693_abnormal_embryo_hatching4.56274858
5MP0003111_abnormal_nucleus_morphology4.41595633
6MP0004957_abnormal_blastocyst_morpholog3.98610867
7MP0003077_abnormal_cell_cycle3.66785386
8MP0008058_abnormal_DNA_repair3.63590059
9MP0008057_abnormal_DNA_replication3.56712791
10MP0003787_abnormal_imprinting2.92603879
11MP0002102_abnormal_ear_morphology2.91125444
12MP0003195_calcinosis2.81775929
13MP0003121_genomic_imprinting2.72482713
14MP0002837_dystrophic_cardiac_calcinosis2.49483696
15MP0008932_abnormal_embryonic_tissue2.48206245
16MP0005551_abnormal_eye_electrophysiolog2.47182621
17MP0008875_abnormal_xenobiotic_pharmacok2.40687134
18* MP0002210_abnormal_sex_determination2.39120723
19MP0002638_abnormal_pupillary_reflex2.36440804
20MP0008007_abnormal_cellular_replicative2.33082185
21MP0003786_premature_aging2.29335533
22MP0001968_abnormal_touch/_nociception2.20078035
23MP0001730_embryonic_growth_arrest2.19909902
24MP0006072_abnormal_retinal_apoptosis2.11606478
25MP0000350_abnormal_cell_proliferation2.11373172
26* MP0001145_abnormal_male_reproductive2.04048630
27MP0009046_muscle_twitch2.00829086
28* MP0001929_abnormal_gametogenesis2.00620974
29MP0002736_abnormal_nociception_after1.95787201
30MP0003011_delayed_dark_adaptation1.94137284
31MP0003567_abnormal_fetal_cardiomyocyte1.92347381
32MP0008872_abnormal_physiological_respon1.87862165
33MP0003718_maternal_effect1.87766298
34MP0001672_abnormal_embryogenesis/_devel1.87562587
35MP0005380_embryogenesis_phenotype1.87562587
36MP0000372_irregular_coat_pigmentation1.86585445
37MP0003646_muscle_fatigue1.85926690
38MP0001986_abnormal_taste_sensitivity1.84867028
39MP0004147_increased_porphyrin_level1.81849171
40MP0005645_abnormal_hypothalamus_physiol1.79360370
41MP0003136_yellow_coat_color1.79298229
42MP0009745_abnormal_behavioral_response1.74794725
43MP0005646_abnormal_pituitary_gland1.74313056
44* MP0000653_abnormal_sex_gland1.73988848
45MP0005253_abnormal_eye_physiology1.73478412
46MP0003315_abnormal_perineum_morphology1.71855990
47MP0003984_embryonic_growth_retardation1.67795118
48MP0004197_abnormal_fetal_growth/weight/1.65866968
49MP0003119_abnormal_digestive_system1.64454109
50MP0010352_gastrointestinal_tract_polyps1.64233970
51MP0003890_abnormal_embryonic-extraembry1.64154963
52MP0004145_abnormal_muscle_electrophysio1.64091357
53MP0002088_abnormal_embryonic_growth/wei1.64022323
54MP0001697_abnormal_embryo_size1.62878926
55* MP0003698_abnormal_male_reproductive1.60175846
56MP0002876_abnormal_thyroid_physiology1.59945982
57MP0002085_abnormal_embryonic_tissue1.58799391
58MP0004142_abnormal_muscle_tone1.57632512
59MP0006276_abnormal_autonomic_nervous1.57319435
60MP0001529_abnormal_vocalization1.57185557
61MP0002084_abnormal_developmental_patter1.56781721
62MP0005084_abnormal_gallbladder_morpholo1.53500598
63MP0004885_abnormal_endolymph1.52543062
64MP0002272_abnormal_nervous_system1.50903427
65MP0003880_abnormal_central_pattern1.50096927
66MP0001485_abnormal_pinna_reflex1.48143286
67MP0001984_abnormal_olfaction1.48032379
68MP0002086_abnormal_extraembryonic_tissu1.45292089
69MP0003941_abnormal_skin_development1.44318748
70MP0003806_abnormal_nucleotide_metabolis1.43036081
71MP0002080_prenatal_lethality1.41960218
72MP0008995_early_reproductive_senescence1.40568426
73MP0009697_abnormal_copulation1.39866411
74MP0000631_abnormal_neuroendocrine_gland1.33701059
75MP0009672_abnormal_birth_weight1.32754431
76MP0001501_abnormal_sleep_pattern1.31987509
77MP0006292_abnormal_olfactory_placode1.28341460
78MP0000566_synostosis1.28297613
79MP0002163_abnormal_gland_morphology1.27876354
80MP0005379_endocrine/exocrine_gland_phen1.26894787
81MP0002653_abnormal_ependyma_morphology1.24678091
82MP0000313_abnormal_cell_death1.21813424
83MP0002396_abnormal_hematopoietic_system1.21168876
84MP0005423_abnormal_somatic_nervous1.19923109
85MP0002735_abnormal_chemical_nociception1.19916829
86MP0004133_heterotaxia1.19674972
87MP0002733_abnormal_thermal_nociception1.17653369
88MP0008789_abnormal_olfactory_epithelium1.16658627
89MP0010307_abnormal_tumor_latency1.16573026
90MP0008775_abnormal_heart_ventricle1.16448407
91* MP0001119_abnormal_female_reproductive1.15793851
92MP0004043_abnormal_pH_regulation1.15428214
93MP0002277_abnormal_respiratory_mucosa1.13522797
94MP0001293_anophthalmia1.12912435
95MP0004215_abnormal_myocardial_fiber1.12621591
96MP0002572_abnormal_emotion/affect_behav1.11206731
97MP0000569_abnormal_digit_pigmentation1.10615163
98* MP0002161_abnormal_fertility/fecundity1.09434445
99MP0005174_abnormal_tail_pigmentation1.07433022
100MP0000490_abnormal_crypts_of1.06957558
101MP0000427_abnormal_hair_cycle1.05687848
102MP0001970_abnormal_pain_threshold1.05109938
103MP0002928_abnormal_bile_duct1.04796036
104MP0004742_abnormal_vestibular_system1.03477630
105MP0001486_abnormal_startle_reflex1.02859524
106MP0010386_abnormal_urinary_bladder1.02755508
107MP0003115_abnormal_respiratory_system1.02380364
108MP0005386_behavior/neurological_phenoty1.01769727
109MP0004924_abnormal_behavior1.01769727
110MP0002019_abnormal_tumor_incidence1.00908933
111MP0001905_abnormal_dopamine_level1.00378489
112MP0002557_abnormal_social/conspecific_i1.00369145
113* MP0005389_reproductive_system_phenotype1.00152695
114MP0002751_abnormal_autonomic_nervous0.99324514
115MP0002064_seizures0.99133912
116MP0003942_abnormal_urinary_system0.98978709
117MP0005195_abnormal_posterior_eye0.97852389
118MP0005410_abnormal_fertilization0.96129053
119MP0008260_abnormal_autophagy0.94145902
120MP0005076_abnormal_cell_differentiation0.93018009
121MP0000537_abnormal_urethra_morphology0.92476553
122MP0002067_abnormal_sensory_capabilities0.91930693
123MP0009703_decreased_birth_body0.91633013
124MP0002138_abnormal_hepatobiliary_system0.91376422
125MP0001764_abnormal_homeostasis0.91141498
126MP0004264_abnormal_extraembryonic_tissu0.90921332
127MP0001286_abnormal_eye_development0.90189450
128MP0001919_abnormal_reproductive_system0.89905998
129MP0003252_abnormal_bile_duct0.89774907
130MP0001177_atelectasis0.89009207
131MP0003137_abnormal_impulse_conducting0.88668760
132MP0005394_taste/olfaction_phenotype0.85312522
133MP0005499_abnormal_olfactory_system0.85312522
134MP0003936_abnormal_reproductive_system0.85083500
135MP0002752_abnormal_somatic_nervous0.83196932
136MP0005085_abnormal_gallbladder_physiolo0.82394939
137MP0002734_abnormal_mechanical_nocicepti0.82176918
138* MP0002160_abnormal_reproductive_system0.81691069
139MP0005332_abnormal_amino_acid0.81470812
140MP0003878_abnormal_ear_physiology0.81295842
141MP0005377_hearing/vestibular/ear_phenot0.81295842
142MP0003937_abnormal_limbs/digits/tail_de0.81173493
143MP0003122_maternal_imprinting0.80638314
144MP0002095_abnormal_skin_pigmentation0.79858418
145MP0002938_white_spotting0.79208357
146MP0000230_abnormal_systemic_arterial0.78619321
147MP0006036_abnormal_mitochondrial_physio0.78395365
148MP0000534_abnormal_ureter_morphology0.77414239
149MP0003635_abnormal_synaptic_transmissio0.76558630
150MP0000538_abnormal_urinary_bladder0.76155669
151MP0005384_cellular_phenotype0.75596021
152MP0005171_absent_coat_pigmentation0.75468374
153MP0003385_abnormal_body_wall0.75019603
154MP0002693_abnormal_pancreas_physiology0.74711096
155MP0003283_abnormal_digestive_organ0.73052008
156MP0001188_hyperpigmentation0.72437937
157MP0000432_abnormal_head_morphology0.69740660
158MP0003861_abnormal_nervous_system0.69340716
159* MP0003699_abnormal_female_reproductive0.68509880
160MP0003755_abnormal_palate_morphology0.68105096
161MP0000428_abnormal_craniofacial_morphol0.66885958
162MP0004808_abnormal_hematopoietic_stem0.63479462
163MP0001915_intracranial_hemorrhage0.63087278
164MP0005621_abnormal_cell_physiology0.62830603
165MP0000358_abnormal_cell_content/0.61894666
166MP0003935_abnormal_craniofacial_develop0.61563775
167MP0002111_abnormal_tail_morphology0.61430131
168MP0001849_ear_inflammation0.60471616
169MP0005395_other_phenotype0.59327245
170MP0002234_abnormal_pharynx_morphology0.58769216
171MP0002132_abnormal_respiratory_system0.57275809
172MP0003566_abnormal_cell_adhesion0.51788205
173MP0002116_abnormal_craniofacial_bone0.51301995
174MP0009053_abnormal_anal_canal0.51049911
175MP0010030_abnormal_orbit_morphology0.49308180
176MP0002114_abnormal_axial_skeleton0.48005480
177MP0002092_abnormal_eye_morphology0.47564242

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)4.76848070
2Diastasis recti (HP:0001540)4.63760275
3Breast hypoplasia (HP:0003187)4.44358795
4Pancreatic cysts (HP:0001737)4.19782788
5Birth length less than 3rd percentile (HP:0003561)4.12592986
6Abnormality of the labia minora (HP:0012880)4.05075512
7Hepatoblastoma (HP:0002884)3.98852785
8Congenital stationary night blindness (HP:0007642)3.95721212
9Impulsivity (HP:0100710)3.79435610
10Pancreatic fibrosis (HP:0100732)3.77171914
11Abnormality of midbrain morphology (HP:0002418)3.76127822
12Molar tooth sign on MRI (HP:0002419)3.76127822
13True hermaphroditism (HP:0010459)3.70247145
14Nephroblastoma (Wilms tumor) (HP:0002667)3.67941709
15Supernumerary spleens (HP:0009799)3.58771548
16Meckel diverticulum (HP:0002245)3.54652152
17Patellar aplasia (HP:0006443)3.54495784
18Gonadotropin excess (HP:0000837)3.49751470
19Type II lissencephaly (HP:0007260)3.49170679
20Abnormal spermatogenesis (HP:0008669)3.46848355
21Ependymoma (HP:0002888)3.45489918
22Abnormality of the anterior horn cell (HP:0006802)3.44322490
23Degeneration of anterior horn cells (HP:0002398)3.44322490
24Embryonal renal neoplasm (HP:0011794)3.43507187
25Abnormality of the ileum (HP:0001549)3.39563939
26Carpal bone hypoplasia (HP:0001498)3.38724229
27Selective tooth agenesis (HP:0001592)3.37797318
28Aplasia/Hypoplasia of the patella (HP:0006498)3.30250939
29Absent radius (HP:0003974)3.28040328
30Nephronophthisis (HP:0000090)3.24463053
31Chromsome breakage (HP:0040012)3.11568280
32Azoospermia (HP:0000027)3.10696453
33Chromosomal breakage induced by crosslinking agents (HP:0003221)3.07712867
34Medulloblastoma (HP:0002885)3.06265128
35Aplasia involving forearm bones (HP:0009822)3.05571598
36Absent forearm bone (HP:0003953)3.05571598
37Abolished electroretinogram (ERG) (HP:0000550)3.04377301
38Abnormality of the renal cortex (HP:0011035)3.01629042
39Abnormal rod and cone electroretinograms (HP:0008323)3.00569900
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.99984401
41Abnormality of alanine metabolism (HP:0010916)2.99984401
42Hyperalaninemia (HP:0003348)2.99984401
43Attenuation of retinal blood vessels (HP:0007843)2.99237436
44Abnormality of the preputium (HP:0100587)2.94566836
45Shawl scrotum (HP:0000049)2.93201433
46Cerebral hypomyelination (HP:0006808)2.86329477
47Neoplasm of the adrenal cortex (HP:0100641)2.80874771
48Abnormality of the renal medulla (HP:0100957)2.80745307
49Facial hemangioma (HP:0000329)2.77842886
50Abnormality of chromosome stability (HP:0003220)2.75937376
51Decreased electroretinogram (ERG) amplitude (HP:0000654)2.75407593
52Hypoplasia of the fovea (HP:0007750)2.75391164
53Aplasia/Hypoplasia of the fovea (HP:0008060)2.75391164
54Medial flaring of the eyebrow (HP:0010747)2.73220037
55Agnosia (HP:0010524)2.70102895
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.69966535
57Pendular nystagmus (HP:0012043)2.69584533
58Biliary tract neoplasm (HP:0100574)2.67370511
5911 pairs of ribs (HP:0000878)2.61436845
60Cerebellar dysplasia (HP:0007033)2.59224077
61Chronic hepatic failure (HP:0100626)2.58031200
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.56607390
63Acute necrotizing encephalopathy (HP:0006965)2.54969190
64Rhabdomyosarcoma (HP:0002859)2.50779480
65Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.48711913
66Neoplasm of the pancreas (HP:0002894)2.46283308
67Tubular atrophy (HP:0000092)2.44035919
68Hypothermia (HP:0002045)2.42025273
69Increased CSF lactate (HP:0002490)2.40983369
70Mitochondrial inheritance (HP:0001427)2.40818251
71Absent thumb (HP:0009777)2.38923244
72Cystic liver disease (HP:0006706)2.37705557
73Broad alveolar ridges (HP:0000187)2.37554319
74Decreased central vision (HP:0007663)2.37139808
75Rough bone trabeculation (HP:0100670)2.33474884
76Atrophy/Degeneration involving motor neurons (HP:0007373)2.32026573
77Oral leukoplakia (HP:0002745)2.31583204
78Abnormality of the fovea (HP:0000493)2.31479494
79Acute encephalopathy (HP:0006846)2.31241330
80Abnormality of the astrocytes (HP:0100707)2.30238199
81Astrocytoma (HP:0009592)2.30238199
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.30211027
83Lissencephaly (HP:0001339)2.29396099
84Abnormal biliary tract morphology (HP:0012440)2.28312437
85Large for gestational age (HP:0001520)2.28212486
86Gaze-evoked nystagmus (HP:0000640)2.28200953
87Glioma (HP:0009733)2.27656534
88Abnormal drinking behavior (HP:0030082)2.27175562
89Polydipsia (HP:0001959)2.27175562
90Sclerocornea (HP:0000647)2.26599266
91Bone marrow hypocellularity (HP:0005528)2.26496825
92Inability to walk (HP:0002540)2.26202779
93Progressive macrocephaly (HP:0004481)2.25411857
94Optic nerve hypoplasia (HP:0000609)2.24030654
95Abnormality of the pons (HP:0007361)2.23432422
96Abnormal lung lobation (HP:0002101)2.22788848
97Hyperventilation (HP:0002883)2.18327017
98Renal cortical cysts (HP:0000803)2.16851987
99Tongue fasciculations (HP:0001308)2.16495489
100Duodenal stenosis (HP:0100867)2.14470661
101Small intestinal stenosis (HP:0012848)2.14470661
102Missing ribs (HP:0000921)2.14375137
103Premature ovarian failure (HP:0008209)2.14309320
104Congenital, generalized hypertrichosis (HP:0004540)2.13911381
105Neoplasm of the oral cavity (HP:0100649)2.13292208
106Hypoplasia of the pons (HP:0012110)2.12369551
107Myelodysplasia (HP:0002863)2.11190861
108Anencephaly (HP:0002323)2.10502359
109Abnormality of lateral ventricle (HP:0030047)2.10016384
110Methylmalonic acidemia (HP:0002912)2.09134925
111Neoplasm of the colon (HP:0100273)2.08855505
112Adrenal hypoplasia (HP:0000835)2.07640298
113Bony spicule pigmentary retinopathy (HP:0007737)2.06822204
114Absent/shortened dynein arms (HP:0200106)2.06743759
115Dynein arm defect of respiratory motile cilia (HP:0012255)2.06743759
116Rectovaginal fistula (HP:0000143)2.06007396
117Rectal fistula (HP:0100590)2.06007396
118Type 2 muscle fiber atrophy (HP:0003554)2.05781384
119Abnormal mitochondria in muscle tissue (HP:0008316)2.05500482
120Premature graying of hair (HP:0002216)2.05402970
121Retinal dysplasia (HP:0007973)2.05072032
122Keratoconus (HP:0000563)2.05043809
123Increased corneal curvature (HP:0100692)2.05043809
124Severe muscular hypotonia (HP:0006829)2.04705454
125Aplasia/hypoplasia of the humerus (HP:0006507)2.03709561
126Progressive inability to walk (HP:0002505)2.03637709
127Gait imbalance (HP:0002141)2.02837372
128Proximal placement of thumb (HP:0009623)2.02540484
129Abnormal pancreas size (HP:0012094)2.01847617
130Abnormal ventriculo-arterial connection (HP:0011563)2.01455357
131Transposition of the great arteries (HP:0001669)2.01455357
132Abnormal connection of the cardiac segments (HP:0011545)2.01455357
133Congenital primary aphakia (HP:0007707)2.01247223
134Furrowed tongue (HP:0000221)2.01236174
135Spinal muscular atrophy (HP:0007269)2.00411983
136Aplasia/Hypoplasia of the tongue (HP:0010295)2.00252752
137Abnormal number of incisors (HP:0011064)2.00185922
138Nephrogenic diabetes insipidus (HP:0009806)1.99578733
139Capillary hemangiomas (HP:0005306)1.97783543
140Lipid accumulation in hepatocytes (HP:0006561)1.97265870
141Metaphyseal dysplasia (HP:0100255)1.96801650
142Increased hepatocellular lipid droplets (HP:0006565)1.96206650
143Hepatic necrosis (HP:0002605)1.95071710
144Optic disc pallor (HP:0000543)1.94954083
145Deviation of the thumb (HP:0009603)1.94087781
146Tracheoesophageal fistula (HP:0002575)1.93198663
147Hepatocellular necrosis (HP:0001404)1.92841832
148Genetic anticipation (HP:0003743)1.92586884
149Hyperglycinuria (HP:0003108)1.92131326
150Neoplasm of striated muscle (HP:0009728)1.91492594
151Congenital hepatic fibrosis (HP:0002612)1.91236113
152Triphalangeal thumb (HP:0001199)1.89919114
153High anterior hairline (HP:0009890)1.89668023
154Secondary amenorrhea (HP:0000869)1.89503199
155Abnormality of the fetal cardiovascular system (HP:0010948)1.89384060
156Abnormal umbilical cord blood vessels (HP:0011403)1.89384060
157Single umbilical artery (HP:0001195)1.89384060
158Congenital sensorineural hearing impairment (HP:0008527)1.89221864
159Polyuria (HP:0000103)1.88371252
160Sloping forehead (HP:0000340)1.87665828
161Horseshoe kidney (HP:0000085)1.87636398
162Embryonal neoplasm (HP:0002898)1.86861061
163Progressive cerebellar ataxia (HP:0002073)1.86224377
164Muscle fibrillation (HP:0010546)1.85623746
165Abnormal biliary tract physiology (HP:0012439)1.85544564
166Bile duct proliferation (HP:0001408)1.85544564
167Methylmalonic aciduria (HP:0012120)1.85507851
168Prominent nose (HP:0000448)1.85035896
169Pelvic girdle muscle weakness (HP:0003749)1.85001789
170Ketoacidosis (HP:0001993)1.84930370
171Aplasia/Hypoplasia of the sternum (HP:0006714)1.83908154
172Reticulocytopenia (HP:0001896)1.83783151
173Metaphyseal cupping (HP:0003021)1.82983079
174Aplasia/Hypoplasia of the tibia (HP:0005772)1.82741850
175Abnormality of the duodenum (HP:0002246)1.82240932
176Postaxial foot polydactyly (HP:0001830)1.82149205
177Male pseudohermaphroditism (HP:0000037)1.79501601
178Aplasia/Hypoplasia of the breasts (HP:0010311)1.79196298
179Constricted visual fields (HP:0001133)1.78698265
180Ectopic kidney (HP:0000086)1.77540696
181Breast aplasia (HP:0100783)1.77511293
182Ovarian neoplasm (HP:0100615)1.77449332
183Neoplasm of the rectum (HP:0100743)1.77283992
184Increased serum lactate (HP:0002151)1.76799694
185Stenosis of the external auditory canal (HP:0000402)1.74444214
186Ketosis (HP:0001946)1.71701094
187Chorioretinal atrophy (HP:0000533)1.71182264
188Genital tract atresia (HP:0001827)1.70119693
189Intestinal atresia (HP:0011100)1.69519997
190Decreased circulating renin level (HP:0003351)1.69460854
191Aplasia/Hypoplasia affecting the retina (HP:0008061)1.69376396
192Dandy-Walker malformation (HP:0001305)1.69354881

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.02022879
2FRK4.97420033
3BUB14.53602233
4WEE14.28762684
5CDK124.04280205
6AKT33.31358215
7ADRBK23.13259776
8BMPR1B2.97347203
9TTK2.81191711
10NEK12.59633043
11PDK32.50954956
12PDK42.50954956
13ACVR1B2.48805614
14MAP4K22.43448858
15GRK12.40980344
16TAOK32.39479263
17BRSK22.28360044
18NEK22.25645425
19PLK12.22650665
20TSSK62.21176411
21WNK42.18647651
22SRPK12.13279155
23PINK12.08898610
24BRSK11.95972368
25PNCK1.93784342
26MKNK21.89802981
27PLK31.86811848
28CASK1.85347519
29CHEK21.75925905
30VRK21.70059805
31MKNK11.66593888
32EIF2AK11.64513472
33OXSR11.63545403
34INSRR1.62787447
35CDK71.60899217
36PASK1.59907789
37EPHA21.57961355
38PDK21.50347802
39EPHA41.48738401
40BRAF1.47679516
41PLK41.46067881
42ATR1.44021538
43CHEK11.43165238
44TRIM281.39414045
45AURKB1.39007505
46BRD41.35410609
47TXK1.30530615
48VRK11.30461102
49PRKD31.29883424
50STK391.28054390
51MAP3K41.26166325
52STK38L1.22345886
53MST41.18750265
54CLK11.18356574
55TNIK1.15588953
56ZAK1.15134752
57AURKA1.08085449
58DAPK21.07866466
59ADRBK11.06518098
60TIE11.04359918
61CDK41.02207008
62MELK1.00477824
63CDK190.98874987
64MAP3K60.98291366
65DYRK30.97986888
66CDK20.97860215
67MAPKAPK50.94224360
68YES10.94069113
69TLK10.90886442
70TGFBR10.90594371
71EIF2AK30.89093637
72LATS20.88668019
73PRKCG0.88203755
74CSNK1G30.87005673
75CSNK1G20.86092855
76CSNK1G10.84459429
77PAK30.83029472
78MAPK150.82662255
79CDK10.81826420
80TAF10.81692060
81PTK2B0.81531680
82ATM0.80897080
83MAPKAPK30.79575447
84RPS6KA50.78083191
85PHKG20.77204753
86PHKG10.77204753
87ALK0.77038327
88MUSK0.76839709
89STK40.73691885
90PRKCE0.70744884
91MAP2K70.69283489
92PLK20.67856674
93CSNK2A10.66517481
94STK30.65740644
95PIK3CA0.64881767
96CSNK2A20.62921013
97DYRK20.62192958
98TESK20.61904372
99RPS6KB20.61433602
100NME10.60870792
101IKBKB0.60445774
102OBSCN0.60382543
103TEC0.59227657
104PRKCI0.58443098
105STK110.58154173
106NME20.57429548
107CSNK1A1L0.55307226
108STK160.54856024
109MAP2K60.54208700
110PRKCQ0.53275921
111FGFR20.52766409
112PAK10.51756136
113MAP3K90.51489915
114FLT30.49569157
115PIM10.48926646
116NUAK10.48548142
117ZAP700.48040763
118CSNK1E0.47236391
119MARK30.47003041
120MARK10.46764363
121CAMK2A0.46681273
122PAK40.46394132
123MAP3K80.46001395
124PKN10.45295942
125PIK3CG0.44816288
126DYRK1A0.43556914
127CAMKK20.43190208
128MAPK130.42687199
129KIT0.42227554
130KSR10.41204427
131PRKACA0.40073358
132TRPM70.39834466
133CSNK1A10.39541971
134PBK0.39263946
135MAP2K30.38999847
136MAP3K130.38763156
137STK240.35754490
138MTOR0.35301235
139RPS6KA40.32122682
140PRKCA0.31051603
141NTRK30.30727206
142BCR0.30383854
143MAPK140.30048880
144ITK0.30003275
145PRKDC0.29807272
146GSK3B0.29624527
147IRAK10.29390614
148CHUK0.28656800
149CSNK1D0.27264533
150WNK30.27179792
151MAPK100.24949799
152ICK0.24329452
153CCNB10.22004131
154PRKD20.21886651
155AKT10.21318311
156MAP3K30.21276619
157CDK80.21206725
158CDK60.20892845
159BCKDK0.20541066
160MAPK10.16815283
161LATS10.15512409
162MAPK80.15465766
163SIK30.14682038
164NLK0.13635860
165TYRO30.12849501
166FGFR10.12796496

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.14184028
2Mismatch repair_Homo sapiens_hsa034304.94308178
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.34415301
4Proteasome_Homo sapiens_hsa030503.58192989
5Base excision repair_Homo sapiens_hsa034103.56320866
6RNA transport_Homo sapiens_hsa030133.45241380
7RNA polymerase_Homo sapiens_hsa030203.40001636
8Spliceosome_Homo sapiens_hsa030403.29084281
9Homologous recombination_Homo sapiens_hsa034403.26409601
10Cell cycle_Homo sapiens_hsa041103.08016940
11Nucleotide excision repair_Homo sapiens_hsa034203.04274747
12Phototransduction_Homo sapiens_hsa047442.90562532
13Fanconi anemia pathway_Homo sapiens_hsa034602.75326987
14Caffeine metabolism_Homo sapiens_hsa002322.54689470
15Oxidative phosphorylation_Homo sapiens_hsa001902.51436079
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.45829142
17Basal transcription factors_Homo sapiens_hsa030222.39625554
18Pyrimidine metabolism_Homo sapiens_hsa002402.37676362
19Maturity onset diabetes of the young_Homo sapiens_hsa049502.32753866
20Nitrogen metabolism_Homo sapiens_hsa009102.28469982
21One carbon pool by folate_Homo sapiens_hsa006702.22469254
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19995011
23Butanoate metabolism_Homo sapiens_hsa006502.14499370
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.02776674
25RNA degradation_Homo sapiens_hsa030182.02451950
26mRNA surveillance pathway_Homo sapiens_hsa030152.00682688
27Parkinsons disease_Homo sapiens_hsa050121.94870065
28Ribosome_Homo sapiens_hsa030101.89191640
29Tryptophan metabolism_Homo sapiens_hsa003801.80467456
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.76394673
31Non-homologous end-joining_Homo sapiens_hsa034501.67234753
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.65179269
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62483800
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.58100149
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57679482
36Oocyte meiosis_Homo sapiens_hsa041141.52909473
37Ether lipid metabolism_Homo sapiens_hsa005651.51671398
38Vitamin B6 metabolism_Homo sapiens_hsa007501.45287587
39Nicotine addiction_Homo sapiens_hsa050331.43562885
40Propanoate metabolism_Homo sapiens_hsa006401.42968301
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.39358764
42Purine metabolism_Homo sapiens_hsa002301.38409556
43Olfactory transduction_Homo sapiens_hsa047401.32364728
44p53 signaling pathway_Homo sapiens_hsa041151.26718107
45Selenocompound metabolism_Homo sapiens_hsa004501.23121875
46Cardiac muscle contraction_Homo sapiens_hsa042601.21523570
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19094458
48Epstein-Barr virus infection_Homo sapiens_hsa051691.10519341
49Alzheimers disease_Homo sapiens_hsa050101.09803188
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.09544223
51Taste transduction_Homo sapiens_hsa047421.06428000
52Peroxisome_Homo sapiens_hsa041460.99758295
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97944800
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.96436834
55Asthma_Homo sapiens_hsa053100.96435137
56Chemical carcinogenesis_Homo sapiens_hsa052040.96287253
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95231543
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93341271
59Retinol metabolism_Homo sapiens_hsa008300.92867443
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.92495114
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.91230918
62Collecting duct acid secretion_Homo sapiens_hsa049660.88354279
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86927995
64ABC transporters_Homo sapiens_hsa020100.83667618
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83003785
66Fat digestion and absorption_Homo sapiens_hsa049750.76275439
67Pentose phosphate pathway_Homo sapiens_hsa000300.75899440
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73855463
69Morphine addiction_Homo sapiens_hsa050320.73708159
70Biosynthesis of amino acids_Homo sapiens_hsa012300.71912949
71Serotonergic synapse_Homo sapiens_hsa047260.70398843
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.70380499
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69989712
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69516381
75Fructose and mannose metabolism_Homo sapiens_hsa000510.69099671
76Hippo signaling pathway_Homo sapiens_hsa043900.68719378
77Type I diabetes mellitus_Homo sapiens_hsa049400.68500028
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68032617
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67675508
80Sulfur relay system_Homo sapiens_hsa041220.66677340
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65106919
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64462902
83MicroRNAs in cancer_Homo sapiens_hsa052060.64013649
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61881465
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.61619806
86Primary immunodeficiency_Homo sapiens_hsa053400.60883867
87Insulin secretion_Homo sapiens_hsa049110.60307618
88Ovarian steroidogenesis_Homo sapiens_hsa049130.58209335
89HTLV-I infection_Homo sapiens_hsa051660.57514218
90Fatty acid elongation_Homo sapiens_hsa000620.56287540
91Steroid biosynthesis_Homo sapiens_hsa001000.55329029
92GABAergic synapse_Homo sapiens_hsa047270.55123392
93beta-Alanine metabolism_Homo sapiens_hsa004100.55111618
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54856003
95Viral carcinogenesis_Homo sapiens_hsa052030.53811389
96Regulation of autophagy_Homo sapiens_hsa041400.52472298
97Thyroid cancer_Homo sapiens_hsa052160.50433904
98Vitamin digestion and absorption_Homo sapiens_hsa049770.50394218
99Glutathione metabolism_Homo sapiens_hsa004800.50287446
100Basal cell carcinoma_Homo sapiens_hsa052170.49631510
101Huntingtons disease_Homo sapiens_hsa050160.49350954
102Systemic lupus erythematosus_Homo sapiens_hsa053220.48342218
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48265349
104Colorectal cancer_Homo sapiens_hsa052100.47188490
105Folate biosynthesis_Homo sapiens_hsa007900.46997867
106Glycerolipid metabolism_Homo sapiens_hsa005610.46559752
107Herpes simplex infection_Homo sapiens_hsa051680.46119291
108Fatty acid degradation_Homo sapiens_hsa000710.45788197
109Calcium signaling pathway_Homo sapiens_hsa040200.45589327
110Lysine degradation_Homo sapiens_hsa003100.45368653
111Carbon metabolism_Homo sapiens_hsa012000.45048636
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44662801
113Circadian entrainment_Homo sapiens_hsa047130.44141156
114Adherens junction_Homo sapiens_hsa045200.43486384
115Sulfur metabolism_Homo sapiens_hsa009200.43164806
116Allograft rejection_Homo sapiens_hsa053300.43107736
117Hedgehog signaling pathway_Homo sapiens_hsa043400.42390841
118Glutamatergic synapse_Homo sapiens_hsa047240.41888445
119Notch signaling pathway_Homo sapiens_hsa043300.41340955
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41252948
121Salivary secretion_Homo sapiens_hsa049700.40676248
122TGF-beta signaling pathway_Homo sapiens_hsa043500.40124463
123Autoimmune thyroid disease_Homo sapiens_hsa053200.39474859
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39043540
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38650990
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38296516
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37883852
128Arachidonic acid metabolism_Homo sapiens_hsa005900.37883246
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36201795
130Prostate cancer_Homo sapiens_hsa052150.32879080
131Galactose metabolism_Homo sapiens_hsa000520.30475634
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30098348
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28783421
134Tight junction_Homo sapiens_hsa045300.27901341
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.26890312
136mTOR signaling pathway_Homo sapiens_hsa041500.26109777
137Pyruvate metabolism_Homo sapiens_hsa006200.25466321
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25058020
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21749158
140Wnt signaling pathway_Homo sapiens_hsa043100.21162226
141Metabolic pathways_Homo sapiens_hsa011000.20839125
142N-Glycan biosynthesis_Homo sapiens_hsa005100.20517421
143Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20274761
144Antigen processing and presentation_Homo sapiens_hsa046120.19130939
145Small cell lung cancer_Homo sapiens_hsa052220.18561339
146Pathways in cancer_Homo sapiens_hsa052000.14610142
147Linoleic acid metabolism_Homo sapiens_hsa005910.14522038
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.13517848
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13377610
150Protein export_Homo sapiens_hsa030600.12827501
151HIF-1 signaling pathway_Homo sapiens_hsa040660.12663670
152Endometrial cancer_Homo sapiens_hsa052130.08280151
153Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.08009142
154Alcoholism_Homo sapiens_hsa050340.07720388
155Dorso-ventral axis formation_Homo sapiens_hsa043200.04034866
156FoxO signaling pathway_Homo sapiens_hsa040680.03904464
157Melanoma_Homo sapiens_hsa052180.03346539
158Shigellosis_Homo sapiens_hsa051310.02841822
159Legionellosis_Homo sapiens_hsa051340.02367172
160Glucagon signaling pathway_Homo sapiens_hsa049220.01645729
161Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.00179506
162Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860-0.0232569
163alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0135692
164Arginine and proline metabolism_Homo sapiens_hsa00330-0.0135417

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