DMD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene spans a genomic range of greater than 2 Mb and encodes a large protein containing an N-terminal actin-binding domain and multiple spectrin repeats. The encoded protein forms a component of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix. Deletions, duplications, and point mutations at this gene locus may cause Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or cardiomyopathy. Alternative promoter usage and alternative splicing result in numerous distinct transcript variants and protein isoforms for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* actin-mediated cell contraction (GO:0070252)5.69563502
2cardiac muscle cell development (GO:0055013)4.76152986
3relaxation of cardiac muscle (GO:0055119)4.60063413
4cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.52883136
5cardiac cell development (GO:0055006)4.51158607
6actomyosin structure organization (GO:0031032)4.48817233
7retinal cone cell development (GO:0046549)4.43663742
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.40865006
9* regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.40366866
10response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.40308749
11cell communication by electrical coupling (GO:0010644)4.28242180
12response to inactivity (GO:0014854)4.21674709
13* actin filament-based movement (GO:0030048)4.21459417
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.19620293
15* regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.13338801
16* regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.10837589
17response to caffeine (GO:0031000)4.07601105
18relaxation of muscle (GO:0090075)4.02564238
19membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.97882119
20regulation of rhodopsin mediated signaling pathway (GO:0022400)3.94110729
21* regulation of skeletal muscle contraction (GO:0014819)3.91897351
22regulation of the force of heart contraction (GO:0002026)3.86251947
23detection of light stimulus involved in visual perception (GO:0050908)3.85439769
24detection of light stimulus involved in sensory perception (GO:0050962)3.85439769
25rhodopsin mediated signaling pathway (GO:0016056)3.85050844
26cardiac muscle tissue morphogenesis (GO:0055008)3.83815160
27* regulation of striated muscle contraction (GO:0006942)3.81458297
28muscle tissue morphogenesis (GO:0060415)3.78840487
29skeletal muscle contraction (GO:0003009)3.69466962
30relaxation of smooth muscle (GO:0044557)3.64402290
31* muscle contraction (GO:0006936)3.62429682
32negative regulation of cytosolic calcium ion concentration (GO:0051481)3.58036182
33sarcoplasmic reticulum calcium ion transport (GO:0070296)3.57621422
34regulation of membrane repolarization (GO:0060306)3.56318060
35eye photoreceptor cell development (GO:0042462)3.54608947
36photoreceptor cell development (GO:0042461)3.53854641
37cell communication involved in cardiac conduction (GO:0086065)3.53612548
38retinal rod cell development (GO:0046548)3.52990622
39photoreceptor cell maintenance (GO:0045494)3.51993032
40cellular potassium ion homeostasis (GO:0030007)3.47347580
41positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.46141329
42positive regulation of cardiac muscle cell differentiation (GO:2000727)3.44007777
43* muscle fiber development (GO:0048747)3.42245051
44* muscle system process (GO:0003012)3.42111822
45positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.38814756
46regulation of short-term neuronal synaptic plasticity (GO:0048172)3.37890767
47cardiac muscle adaptation (GO:0014887)3.37843047
48cardiac muscle hypertrophy in response to stress (GO:0014898)3.37843047
49muscle hypertrophy in response to stress (GO:0003299)3.37843047
50G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.34880803
51regulation of cell communication by electrical coupling (GO:0010649)3.34876415
52fatty acid transmembrane transport (GO:1902001)3.34069332
53protein localization to synapse (GO:0035418)3.33244952
54cellular response to epinephrine stimulus (GO:0071872)3.28264791
55* regulation of cardiac muscle contraction (GO:0055117)3.26550409
56cardiac myofibril assembly (GO:0055003)3.26169465
57regulation of relaxation of muscle (GO:1901077)3.22996650
58striated muscle adaptation (GO:0014888)3.22485733
59regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.20057439
60* striated muscle cell development (GO:0055002)3.17212753
61atrial cardiac muscle cell action potential (GO:0086014)3.13090640
62cardiac chamber formation (GO:0003207)3.12667877
63negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.09385143
64positive regulation of cation channel activity (GO:2001259)3.08738896
65vocalization behavior (GO:0071625)3.08535051
66ventricular cardiac muscle cell action potential (GO:0086005)3.07535391
67glutamate receptor signaling pathway (GO:0007215)3.06700141
68neurotransmitter-gated ion channel clustering (GO:0072578)3.04838505
69neuronal action potential propagation (GO:0019227)3.04484160
70regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.04393369
71sequestering of extracellular ligand from receptor (GO:0035581)3.03710998
72cardiac muscle hypertrophy (GO:0003300)3.03537906
73negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.03144822
74ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.01674030
75skeletal muscle adaptation (GO:0043501)3.01178872
76* regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.00175884
77sarcomere organization (GO:0045214)2.98979316
78neuron cell-cell adhesion (GO:0007158)2.95329041
79innervation (GO:0060384)2.94466284
80* regulation of muscle system process (GO:0090257)2.94267852
81striated muscle hypertrophy (GO:0014897)2.94219107
82ionotropic glutamate receptor signaling pathway (GO:0035235)2.94122073
83photoreceptor cell differentiation (GO:0046530)2.93298435
84eye photoreceptor cell differentiation (GO:0001754)2.93298435
85* regulation of heart rate (GO:0002027)2.92662006
86cardiac ventricle formation (GO:0003211)2.92637305
87interkinetic nuclear migration (GO:0022027)2.91999910
88response to muscle activity (GO:0014850)2.91287109
89regulation of actin filament-based movement (GO:1903115)2.91039320
90synaptic vesicle docking involved in exocytosis (GO:0016081)2.88762536
91cardiac muscle cell action potential involved in contraction (GO:0086002)2.88114371
92* cardiac muscle cell action potential (GO:0086001)2.88114371
93potassium ion import (GO:0010107)2.87129303
94regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.86233106
95regulation of skeletal muscle cell differentiation (GO:2001014)2.86208978
96detection of calcium ion (GO:0005513)2.85229785
97myofibril assembly (GO:0030239)2.84976612
98response to histamine (GO:0034776)2.84899573
99negative regulation of potassium ion transmembrane transport (GO:1901380)2.84870700
100positive regulation of potassium ion transmembrane transport (GO:1901381)2.84378859
101regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.82828023
102* regulation of muscle contraction (GO:0006937)2.79924186
103positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.78783587
104membrane hyperpolarization (GO:0060081)2.78603792
105negative regulation of calcium ion transmembrane transport (GO:1903170)2.78418445
106negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.78418445
107* cardiac muscle contraction (GO:0060048)2.77583404
108synaptic transmission, glutamatergic (GO:0035249)2.76960003
109regulation of cardiac muscle cell differentiation (GO:2000725)2.76095563
110carnitine transmembrane transport (GO:1902603)2.75756419
111neuron-neuron synaptic transmission (GO:0007270)2.75715510
112membrane depolarization during action potential (GO:0086010)2.74449104
113regulation of ATPase activity (GO:0043462)2.74396500
114regulation of ATP catabolic process (GO:1903289)2.74396500
115* muscle cell development (GO:0055001)2.72936627
116negative regulation of protein localization to cell surface (GO:2000009)2.72674296
117presynaptic membrane assembly (GO:0097105)2.71704595
118positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.70267523
119synaptic vesicle exocytosis (GO:0016079)2.70148175
120retina layer formation (GO:0010842)2.69842383
121glutamate secretion (GO:0014047)2.69541196
122cGMP-mediated signaling (GO:0019934)2.68179746
123sodium ion export (GO:0071436)2.68107020
124regulation of cardiac muscle cell contraction (GO:0086004)2.67749508
125regulation of glutamate receptor signaling pathway (GO:1900449)2.67461041
126positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.67166713
127* striated muscle contraction (GO:0006941)2.66455473
128potassium ion homeostasis (GO:0055075)2.64846799
129skeletal muscle fiber development (GO:0048741)2.62404698
130positive regulation of heart rate (GO:0010460)2.61912916
131regulation of cardioblast differentiation (GO:0051890)2.61795667
132cardiac conduction (GO:0061337)2.61710268
133locomotory exploration behavior (GO:0035641)2.61149808
134regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.60292531
135regulation of potassium ion transmembrane transport (GO:1901379)2.59978300
136* regulation of heart contraction (GO:0008016)2.59788360
137regulation of heart rate by cardiac conduction (GO:0086091)2.59156905
138regulation of postsynaptic membrane potential (GO:0060078)2.57009115
139otic vesicle formation (GO:0030916)2.56487321
140response to epinephrine (GO:0071871)2.55093443
141L-amino acid import (GO:0043092)2.54870814
142detection of light stimulus (GO:0009583)2.53026719
143detection of visible light (GO:0009584)2.52529588
144adrenergic receptor signaling pathway (GO:0071875)2.51836271
145muscle hypertrophy (GO:0014896)2.51075271
146* regulation of calcium ion transmembrane transport (GO:1903169)2.50443992
147* regulation of calcium ion transmembrane transporter activity (GO:1901019)2.50443992
148phototransduction (GO:0007602)2.49949840
149adult heart development (GO:0007512)2.47588824
150regulation of potassium ion transmembrane transporter activity (GO:1901016)2.47186081
151calcium ion import (GO:0070509)2.46250756
152* muscle filament sliding (GO:0030049)2.46079906
153* actin-myosin filament sliding (GO:0033275)2.46079906
154regulation of sarcomere organization (GO:0060297)2.45688774
155carnitine shuttle (GO:0006853)2.42890662
156postsynaptic membrane organization (GO:0001941)2.42553111

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.96265930
2EZH2_22144423_ChIP-Seq_EOC_Human3.78801606
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52194198
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.40265448
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31489290
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.22819814
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16795314
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12669169
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.11943860
10AR_21572438_ChIP-Seq_LNCaP_Human2.11847067
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07744416
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.05996729
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.05996729
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.02312748
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01607580
16DROSHA_22980978_ChIP-Seq_HELA_Human1.94936623
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.91324088
18MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89487228
19* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89432590
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88673063
21* SMAD4_21799915_ChIP-Seq_A2780_Human1.84604252
22PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83940370
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81218013
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.80572843
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.80228008
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75766838
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75732408
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75306147
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74763160
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.74401317
31TAF15_26573619_Chip-Seq_HEK293_Human1.72327012
32* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72116582
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.68132787
34TP53_16413492_ChIP-PET_HCT116_Human1.66225809
35P300_19829295_ChIP-Seq_ESCs_Human1.64817529
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.64816939
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60792565
38REST_21632747_ChIP-Seq_MESCs_Mouse1.55347801
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53951576
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.46400161
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46042907
42* CBX2_27304074_Chip-Seq_ESCs_Mouse1.42217789
43FUS_26573619_Chip-Seq_HEK293_Human1.42155082
44VDR_22108803_ChIP-Seq_LS180_Human1.41751963
45* STAT3_23295773_ChIP-Seq_U87_Human1.41308980
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.40608811
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40185824
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40167864
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40167864
50* BCAT_22108803_ChIP-Seq_LS180_Human1.39460463
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38515687
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37027222
53AR_25329375_ChIP-Seq_VCAP_Human1.35348128
54* SOX2_21211035_ChIP-Seq_LN229_Gbm1.35159973
55ARNT_22903824_ChIP-Seq_MCF-7_Human1.34507532
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33228652
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33208920
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33009881
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32328667
60* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31324839
61TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30813061
62* AR_19668381_ChIP-Seq_PC3_Human1.30392892
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.30054236
64* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29946103
65* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29774464
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.29063580
67EWS_26573619_Chip-Seq_HEK293_Human1.29010696
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27049291
69AHR_22903824_ChIP-Seq_MCF-7_Human1.24144807
70* TCF4_23295773_ChIP-Seq_U87_Human1.23991494
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23919486
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.22377838
73ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21593707
74SMAD3_21741376_ChIP-Seq_HESCs_Human1.20406254
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19749598
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.19052277
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18577006
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18577006
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17682748
80RARB_27405468_Chip-Seq_BRAIN_Mouse1.17281586
81LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16905259
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16404784
83CBP_20019798_ChIP-Seq_JUKART_Human1.15622930
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15622930
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14827265
86RNF2_27304074_Chip-Seq_NSC_Mouse1.14544546
87ER_23166858_ChIP-Seq_MCF-7_Human1.13752733
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.13555270
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12500154
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12398846
91* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11918914
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.11828318
93* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11687685
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10781862
95TP53_18474530_ChIP-ChIP_U2OS_Human1.10655242
96REST_18959480_ChIP-ChIP_MESCs_Mouse1.09666797
97ZNF274_21170338_ChIP-Seq_K562_Hela1.09518002
98SMAD4_21741376_ChIP-Seq_HESCs_Human1.08709811
99SOX9_26525672_Chip-Seq_HEART_Mouse1.08482276
100* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07872990
101RUNX2_22187159_ChIP-Seq_PCA_Human1.07797608
102RING1B_27294783_Chip-Seq_ESCs_Mouse1.07590423
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07395752
104ISL1_27105846_Chip-Seq_CPCs_Mouse1.06734728
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06708923
106* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06428879
107TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06316306
108SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06253706
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06214418
110CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06112247
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06064541
112MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.05898773
113CJUN_26792858_Chip-Seq_BT549_Human1.05798504
114CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05606485
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04587532
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04111290
117TBX20_22328084_ChIP-Seq_HEART_Mouse1.03581951
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02343878
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01925510
120ESR1_20079471_ChIP-ChIP_T-47D_Human1.00493976
121IGF1R_20145208_ChIP-Seq_DFB_Human0.98334398
122CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97661371
123PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96775705
124CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96663770

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog3.78261291
2* MP0004215_abnormal_myocardial_fiber3.18975315
3MP0002837_dystrophic_cardiac_calcinosis3.09476616
4* MP0000751_myopathy2.90733482
5MP0004859_abnormal_synaptic_plasticity2.61486572
6MP0006072_abnormal_retinal_apoptosis2.50860616
7MP0004084_abnormal_cardiac_muscle2.48123265
8MP0003011_delayed_dark_adaptation2.47478702
9MP0003646_muscle_fatigue2.44860014
10* MP0005253_abnormal_eye_physiology2.40845256
11MP0003880_abnormal_central_pattern2.39514507
12MP0004270_analgesia2.19969253
13MP0004036_abnormal_muscle_relaxation2.17920811
14MP0004233_abnormal_muscle_weight2.13786540
15MP0001486_abnormal_startle_reflex2.13191308
16MP0003136_yellow_coat_color2.09121438
17MP0003635_abnormal_synaptic_transmissio2.08002727
18* MP0000749_muscle_degeneration2.06141729
19* MP0003137_abnormal_impulse_conducting2.04248176
20MP0009046_muscle_twitch1.96358819
21* MP0005620_abnormal_muscle_contractility1.94926756
22MP0005423_abnormal_somatic_nervous1.83189045
23* MP0005330_cardiomyopathy1.81482459
24MP0009745_abnormal_behavioral_response1.76357289
25MP0004085_abnormal_heartbeat1.75030943
26MP0002063_abnormal_learning/memory/cond1.70649767
27MP0002064_seizures1.69234292
28MP0002972_abnormal_cardiac_muscle1.68652213
29MP0002272_abnormal_nervous_system1.66964598
30MP0004484_altered_response_of1.64579075
31MP0001502_abnormal_circadian_rhythm1.63264851
32MP0002572_abnormal_emotion/affect_behav1.62848573
33MP0005670_abnormal_white_adipose1.60866530
34MP0005646_abnormal_pituitary_gland1.60845294
35* MP0004087_abnormal_muscle_fiber1.58349769
36MP0001968_abnormal_touch/_nociception1.55759952
37MP0002734_abnormal_mechanical_nocicepti1.50426293
38MP0008775_abnormal_heart_ventricle1.49520563
39MP0002067_abnormal_sensory_capabilities1.47668093
40MP0000013_abnormal_adipose_tissue1.45593648
41* MP0002106_abnormal_muscle_physiology1.44289653
42* MP0005195_abnormal_posterior_eye1.44137678
43* MP0002127_abnormal_cardiovascular_syste1.42861753
44* MP0004145_abnormal_muscle_electrophysio1.41550356
45MP0002638_abnormal_pupillary_reflex1.39680302
46MP0009384_cardiac_valve_regurgitation1.38172208
47MP0009780_abnormal_chondrocyte_physiolo1.36417209
48MP0001984_abnormal_olfaction1.36204971
49* MP0002269_muscular_atrophy1.33525308
50MP0004130_abnormal_muscle_cell1.32408793
51MP0001440_abnormal_grooming_behavior1.28658245
52MP0002090_abnormal_vision1.28020171
53* MP0005369_muscle_phenotype1.27055770
54MP0005248_abnormal_Harderian_gland1.20825117
55MP0002229_neurodegeneration1.20554568
56MP0001501_abnormal_sleep_pattern1.17941679
57MP0000778_abnormal_nervous_system1.17848308
58MP0005171_absent_coat_pigmentation1.17156575
59MP0001324_abnormal_eye_pigmentation1.15788349
60MP0004272_abnormal_basement_membrane1.15092850
61* MP0002752_abnormal_somatic_nervous1.14703857
62* MP0002882_abnormal_neuron_morphology1.14079696
63MP0004924_abnormal_behavior1.13580480
64MP0005386_behavior/neurological_phenoty1.13580480
65MP0002557_abnormal_social/conspecific_i1.11410969
66MP0004858_abnormal_nervous_system1.11186259
67MP0002102_abnormal_ear_morphology1.11075441
68MP0001544_abnormal_cardiovascular_syste1.08914735
69MP0005385_cardiovascular_system_phenoty1.08914735
70MP0005623_abnormal_meninges_morphology1.08598222
71* MP0000759_abnormal_skeletal_muscle1.07810877
72MP0006138_congestive_heart_failure1.06042258
73MP0003937_abnormal_limbs/digits/tail_de1.05510652
74MP0004510_myositis1.04140159
75* MP0000750_abnormal_muscle_regeneration1.03897716
76MP0002736_abnormal_nociception_after1.03525872
77* MP0000747_muscle_weakness1.03237071
78MP0008569_lethality_at_weaning1.02258269
79MP0004885_abnormal_endolymph1.02257573
80* MP0010630_abnormal_cardiac_muscle1.01461230
81* MP0000733_abnormal_muscle_development0.99633588
82MP0010368_abnormal_lymphatic_system0.99567021
83MP0002332_abnormal_exercise_endurance0.99538768
84* MP0003950_abnormal_plasma_membrane0.97755075
85MP0002735_abnormal_chemical_nociception0.97698153
86* MP0005391_vision/eye_phenotype0.96781895
87MP0002184_abnormal_innervation0.93906616
88* MP0002108_abnormal_muscle_morphology0.93302196
89MP0006292_abnormal_olfactory_placode0.91828103
90* MP0003634_abnormal_glial_cell0.89883795
91MP0003633_abnormal_nervous_system0.89274246
92* MP0000266_abnormal_heart_morphology0.87157040
93MP0003221_abnormal_cardiomyocyte_apopto0.86769629
94MP0000579_abnormal_nail_morphology0.85983322
95MP0001188_hyperpigmentation0.84585497
96MP0005266_abnormal_metabolism0.83503352
97MP0001299_abnormal_eye_distance/0.83301718
98* MP0002066_abnormal_motor_capabilities/c0.77603314
99MP0001970_abnormal_pain_threshold0.77554099
100MP0002234_abnormal_pharynx_morphology0.77445313
101MP0003690_abnormal_glial_cell0.77351465
102MP0010386_abnormal_urinary_bladder0.76682578
103MP0005595_abnormal_vascular_smooth0.76035525
104MP0003787_abnormal_imprinting0.75483846
105MP0006276_abnormal_autonomic_nervous0.74844893
106MP0000230_abnormal_systemic_arterial0.74120626
107MP0000955_abnormal_spinal_cord0.73872718
108MP0003631_nervous_system_phenotype0.73211588
109MP0005503_abnormal_tendon_morphology0.73136078
110MP0009250_abnormal_appendicular_skeleto0.72764897
111MP0005275_abnormal_skin_tensile0.72602823
112MP0005187_abnormal_penis_morphology0.70483003
113MP0000026_abnormal_inner_ear0.69057793
114MP0000372_irregular_coat_pigmentation0.68103219
115* MP0001963_abnormal_hearing_physiology0.68064541
116MP0000534_abnormal_ureter_morphology0.67965985
117MP0010030_abnormal_orbit_morphology0.67452261
118* MP0002128_abnormal_blood_circulation0.66057130
119MP0000383_abnormal_hair_follicle0.64984340
120MP0003385_abnormal_body_wall0.63189296
121MP0004043_abnormal_pH_regulation0.61833102
122MP0002971_abnormal_brown_adipose0.61051770
123MP0000427_abnormal_hair_cycle0.59072972
124MP0003935_abnormal_craniofacial_develop0.58985979
125MP0001879_abnormal_lymphatic_vessel0.58333498
126MP0000569_abnormal_digit_pigmentation0.57520003
127* MP0001661_extended_life_span0.54773444
128MP0000767_abnormal_smooth_muscle0.54769613
129MP0002822_catalepsy0.53631117
130MP0003890_abnormal_embryonic-extraembry0.53504470
131MP0000566_synostosis0.52901239
132MP0001529_abnormal_vocalization0.52343271
133MP0003879_abnormal_hair_cell0.52027603
134MP0003567_abnormal_fetal_cardiomyocyte0.51595277
135MP0003755_abnormal_palate_morphology0.50996141
136MP0001485_abnormal_pinna_reflex0.50151709

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)7.18378917
2Congenital stationary night blindness (HP:0007642)6.61236335
3Central scotoma (HP:0000603)5.15395450
4Sudden death (HP:0001699)4.75248002
5Scotoma (HP:0000575)4.30747233
6Bony spicule pigmentary retinopathy (HP:0007737)4.13772985
7Focal motor seizures (HP:0011153)3.98301960
8Exercise-induced myalgia (HP:0003738)3.95906243
9Atrial fibrillation (HP:0005110)3.88562561
10Calf muscle hypertrophy (HP:0008981)3.83848988
11Abnormality of macular pigmentation (HP:0008002)3.78704946
12Pigmentary retinal degeneration (HP:0001146)3.72228965
13Chorioretinal atrophy (HP:0000533)3.71701256
14Syncope (HP:0001279)3.70998778
15Muscle hypertrophy of the lower extremities (HP:0008968)3.68596454
16Primary atrial arrhythmia (HP:0001692)3.66856768
17Abnormal rod and cone electroretinograms (HP:0008323)3.47437964
18Dyschromatopsia (HP:0007641)3.46548083
19Neck muscle weakness (HP:0000467)3.46320549
20Supraventricular tachycardia (HP:0004755)3.43851492
21Hip contracture (HP:0003273)3.40792649
22Subaortic stenosis (HP:0001682)3.38778053
23Abnormality of the left ventricular outflow tract (HP:0011103)3.38778053
24Epileptic encephalopathy (HP:0200134)3.38710537
25Supraventricular arrhythmia (HP:0005115)3.36183567
26Febrile seizures (HP:0002373)3.30204720
27Prolonged QT interval (HP:0001657)3.25351442
28* Abnormality of the calf musculature (HP:0001430)3.05950660
29* Dilated cardiomyopathy (HP:0001644)3.00849598
30Muscle fiber splitting (HP:0003555)2.93201369
31Aortic aneurysm (HP:0004942)2.89553493
32Decreased central vision (HP:0007663)2.85218750
33Myopathic facies (HP:0002058)2.84754966
34Attenuation of retinal blood vessels (HP:0007843)2.84179889
35Action tremor (HP:0002345)2.81427406
36Absent rod-and cone-mediated responses on ERG (HP:0007688)2.80950307
37Focal seizures (HP:0007359)2.74957920
38Areflexia of lower limbs (HP:0002522)2.72415075
39Centrally nucleated skeletal muscle fibers (HP:0003687)2.71593870
40Exercise-induced muscle cramps (HP:0003710)2.70986415
41Absent phalangeal crease (HP:0006109)2.68336485
42Keratoconus (HP:0000563)2.65585945
43Increased corneal curvature (HP:0100692)2.65585945
44Ventricular tachycardia (HP:0004756)2.63756012
45Right ventricular cardiomyopathy (HP:0011663)2.63607090
46Hyporeflexia of lower limbs (HP:0002600)2.60451234
47Hyperventilation (HP:0002883)2.60275353
48Ulnar deviation of the wrist (HP:0003049)2.60134514
49EMG: neuropathic changes (HP:0003445)2.59329945
50Pendular nystagmus (HP:0012043)2.57385639
51Frequent falls (HP:0002359)2.54999282
52Abolished electroretinogram (ERG) (HP:0000550)2.53397210
53Ulnar claw (HP:0001178)2.50093212
54Progressive cerebellar ataxia (HP:0002073)2.48781526
55Dysdiadochokinesis (HP:0002075)2.47008838
56Asymmetric septal hypertrophy (HP:0001670)2.46322340
57Abnormal EKG (HP:0003115)2.45071012
58Rhabdomyolysis (HP:0003201)2.41992136
59Hyperkalemia (HP:0002153)2.41192230
60Neoplasm of the heart (HP:0100544)2.39907504
61Ventricular arrhythmia (HP:0004308)2.39031475
62Left ventricular hypertrophy (HP:0001712)2.38687127
63Steppage gait (HP:0003376)2.38597178
64EMG: myopathic abnormalities (HP:0003458)2.33650803
65Increased variability in muscle fiber diameter (HP:0003557)2.31966252
66Abnormal finger flexion creases (HP:0006143)2.31894385
67Calcaneovalgus deformity (HP:0001848)2.29627833
68Fetal akinesia sequence (HP:0001989)2.24196171
69Generalized muscle weakness (HP:0003324)2.24030641
70Difficulty running (HP:0009046)2.22022768
71Abnormality of skeletal muscle fiber size (HP:0012084)2.21797262
72Cone-rod dystrophy (HP:0000548)2.19971471
73Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.16294812
74Type II diabetes mellitus (HP:0005978)2.14615654
75Photophobia (HP:0000613)2.11955804
76Broad-based gait (HP:0002136)2.10677088
77Proximal amyotrophy (HP:0007126)2.05257702
78Severe visual impairment (HP:0001141)2.04615142
79Absence seizures (HP:0002121)2.04155453
80Myoglobinuria (HP:0002913)2.03967923
81Deformed tarsal bones (HP:0008119)2.03585424
82Malignant hyperthermia (HP:0002047)2.03481919
83Generalized tonic-clonic seizures (HP:0002069)2.03318705
84Dysmetric saccades (HP:0000641)2.02902222
85* Muscular dystrophy (HP:0003560)2.02255078
86Hypoplastic ischia (HP:0003175)2.00894369
87Scapular winging (HP:0003691)1.99652935
88Chronic hepatic failure (HP:0100626)1.98634418
89Dialeptic seizures (HP:0011146)1.97360424
90Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.96890547
91Bundle branch block (HP:0011710)1.96611443
92Type 1 muscle fiber predominance (HP:0003803)1.91857269
93Muscle fiber inclusion bodies (HP:0100299)1.90437390
94Retinitis pigmentosa (HP:0000510)1.87325177
95Macular degeneration (HP:0000608)1.87058764
96Heart block (HP:0012722)1.86855180
97* Lipoatrophy (HP:0100578)1.86811294
98Metatarsus adductus (HP:0001840)1.84743770
99Aplasia involving bones of the extremities (HP:0009825)1.84281395
100Aplasia involving bones of the upper limbs (HP:0009823)1.84281395
101Aplasia of the phalanges of the hand (HP:0009802)1.84281395
102Round ear (HP:0100830)1.84250680
103Gaze-evoked nystagmus (HP:0000640)1.84212712
104Drooling (HP:0002307)1.83990365
105Excessive salivation (HP:0003781)1.83990365
106Septo-optic dysplasia (HP:0100842)1.83767352
107Abnormality of the ischium (HP:0003174)1.83493766
108Choroideremia (HP:0001139)1.83130558
109Mildly elevated creatine phosphokinase (HP:0008180)1.83109301
110Gait imbalance (HP:0002141)1.83010610
111Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.82539216
112Hypoplastic left heart (HP:0004383)1.82447375
113Fair hair (HP:0002286)1.81962986
114Atonic seizures (HP:0010819)1.80063697
115* Gowers sign (HP:0003391)1.79902156
116Fatigable weakness (HP:0003473)1.79202963
117Abnormality of the neuromuscular junction (HP:0003398)1.79202963
118Increased connective tissue (HP:0009025)1.78431696
119Abnormality of the shoulder girdle musculature (HP:0001435)1.75951550
120Rimmed vacuoles (HP:0003805)1.74507078
121Congenital primary aphakia (HP:0007707)1.74279455
122Insidious onset (HP:0003587)1.73311482
123Termporal pattern (HP:0011008)1.73311482
124Limited hip movement (HP:0008800)1.73231423
125Myotonia (HP:0002486)1.72765907
126Genetic anticipation (HP:0003743)1.70479979
127Aortic dissection (HP:0002647)1.70298919
128Hemiparesis (HP:0001269)1.69726288
129Abnormal atrioventricular conduction (HP:0005150)1.69217138
130Popliteal pterygium (HP:0009756)1.68149641
131Decreased electroretinogram (ERG) amplitude (HP:0000654)1.67901253
132Ulnar deviation of finger (HP:0009465)1.67226305
133Toxemia of pregnancy (HP:0100603)1.66806927
134Distal arthrogryposis (HP:0005684)1.66233659
135Palpitations (HP:0001962)1.65598245
136Abnormality of the foot musculature (HP:0001436)1.65506740
137Atrioventricular block (HP:0001678)1.63321798
138Truncal ataxia (HP:0002078)1.62735843
139Myokymia (HP:0002411)1.61571050
140Visual hallucinations (HP:0002367)1.61322056
141Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.60827937
142Hammertoe (HP:0001765)1.60514417
143Long clavicles (HP:0000890)1.60510007
144Blue irides (HP:0000635)1.60428290
145Knee flexion contracture (HP:0006380)1.55449877
146Distal lower limb muscle weakness (HP:0009053)1.54001123
147Abnormality of potassium homeostasis (HP:0011042)1.53760063
148Preaxial foot polydactyly (HP:0001841)1.52441097
149Limb-girdle muscle atrophy (HP:0003797)1.50604218
150Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.48599709
151Ventricular fibrillation (HP:0001663)1.48280957
152Weak cry (HP:0001612)1.47819411
153Abnormal ciliary motility (HP:0012262)1.47528476
154Bicuspid aortic valve (HP:0001647)1.44172334
155Bulbar palsy (HP:0001283)1.43307195
156Hypoalphalipoproteinemia (HP:0003233)1.42702297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.18874000
2TNIK3.10218990
3EPHA42.91424957
4PHKG22.89302747
5PHKG12.89302747
6CASK2.75893960
7NTRK32.67614800
8INSRR2.50774145
9MAP3K42.36295064
10DMPK2.13419966
11LMTK21.96249150
12MAP2K71.87608668
13MUSK1.60069705
14AKT31.59604934
15PKN21.59508720
16MKNK21.59251299
17NTRK21.56440660
18PIK3CA1.55867675
19MAP2K41.54438425
20PINK11.50851454
21TTN1.45975167
22MYLK1.41713768
23PAK61.40082560
24ZAK1.37877348
25SGK21.37031409
26MARK11.36677684
27GRK11.33885871
28STK381.23121529
29CAMK2A1.17066596
30KSR11.17057615
31MAPK131.15736598
32SGK4941.14944461
33SGK2231.14944461
34CAMK1G1.13999586
35CAMK2D1.13639567
36MAP3K71.10704131
37SIK11.08007620
38BMPR1B1.06091867
39LATS11.04870790
40NEK91.04405538
41MAPK121.04201388
42SGK31.03591303
43PLK21.02453948
44GRK71.01709318
45MINK11.00510161
46TRPM70.99127752
47NEK10.97865897
48CDC42BPA0.97628024
49EPHA30.95882759
50ACVR1B0.95776187
51PAK30.94988666
52PDK40.92701163
53PDK30.92701163
54PRPF4B0.91316736
55DAPK20.85521617
56WNK10.84710552
57SGK10.83876195
58LIMK10.83778841
59PRKAA20.82776098
60PRKCG0.82635818
61STK390.81990718
62CAMK1D0.81531035
63NLK0.80922408
64MAPK70.79793252
65CDK30.79484164
66ADRBK10.78317720
67PTK2B0.77954455
68PNCK0.77454865
69MAP4K20.76446064
70FLT30.75967559
71PRKCE0.75633534
72STK38L0.75122168
73NTRK10.73484022
74CDK50.73420498
75PRKD30.72904095
76PRKAA10.72754037
77CAMK10.72428928
78ROCK10.72345103
79MAPKAPK30.71799966
80GRK50.68316264
81STK110.67902421
82MAP3K90.67900989
83CCNB10.67678573
84PKN10.66588065
85SIK30.66220830
86TIE10.65908767
87DYRK1A0.61586692
88MAP3K60.60818794
89CAMK40.60144433
90ERBB30.59539311
91PDK20.59329659
92PRKG10.58927599
93PRKACA0.57279238
94NUAK10.56243459
95RPS6KA30.55593640
96MARK20.55474928
97PRKACB0.52881662
98FGFR20.52388594
99BCR0.50830232
100NEK60.50378931
101FER0.50139641
102CAMK2B0.49427339
103FRK0.48674355
104STK240.48357145
105IRAK20.48237408
106CAMK2G0.47333053
107EPHB20.46632008
108RIPK10.44826501
109ICK0.44539132
110BRD40.44485808
111AKT20.44219434
112ROCK20.44124290
113WNK30.43695109
114STK30.43537446
115EEF2K0.43171346
116PRKACG0.42020901
117MAP2K10.41997114
118PIK3CG0.41758495
119OXSR10.41472213
120MELK0.41058120
121ERBB20.40049778
122PRKD10.37801900
123MAPK100.36748381
124MAPK40.34722756
125MET0.33227087
126WNK40.33111729
127TGFBR10.31399167
128RET0.30888968
129FGFR10.29553754
130LATS20.27298786
131ADRBK20.27136102
132MAPK150.27092461
133PAK20.25783400

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.13710437
2Nicotine addiction_Homo sapiens_hsa050333.12880106
3* Dilated cardiomyopathy_Homo sapiens_hsa054142.43782374
4* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.29435856
5Circadian entrainment_Homo sapiens_hsa047132.23644281
6* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.23328989
7GABAergic synapse_Homo sapiens_hsa047272.15815241
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15659042
9Cardiac muscle contraction_Homo sapiens_hsa042602.08189761
10Glutamatergic synapse_Homo sapiens_hsa047241.94997708
11Morphine addiction_Homo sapiens_hsa050321.87120252
12Insulin secretion_Homo sapiens_hsa049111.85417022
13Salivary secretion_Homo sapiens_hsa049701.76640812
14Calcium signaling pathway_Homo sapiens_hsa040201.72489580
15Circadian rhythm_Homo sapiens_hsa047101.70257842
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67442464
17Olfactory transduction_Homo sapiens_hsa047401.65647100
18Renin secretion_Homo sapiens_hsa049241.62027863
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59997392
20Synaptic vesicle cycle_Homo sapiens_hsa047211.59078448
21Oxytocin signaling pathway_Homo sapiens_hsa049211.57697477
22Fatty acid biosynthesis_Homo sapiens_hsa000611.50240997
23Long-term potentiation_Homo sapiens_hsa047201.45569594
24cGMP-PKG signaling pathway_Homo sapiens_hsa040221.43716102
25Taste transduction_Homo sapiens_hsa047421.41880355
26Amphetamine addiction_Homo sapiens_hsa050311.41877330
27Gastric acid secretion_Homo sapiens_hsa049711.36977760
28Cholinergic synapse_Homo sapiens_hsa047251.32650309
29Serotonergic synapse_Homo sapiens_hsa047261.32583173
30Dopaminergic synapse_Homo sapiens_hsa047281.30774893
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30259200
32cAMP signaling pathway_Homo sapiens_hsa040241.26192120
33ABC transporters_Homo sapiens_hsa020101.22088344
34Nitrogen metabolism_Homo sapiens_hsa009101.16960769
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15670163
36Fatty acid metabolism_Homo sapiens_hsa012121.14313705
37Vascular smooth muscle contraction_Homo sapiens_hsa042701.14265270
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14088445
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13132954
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12822973
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10731388
42beta-Alanine metabolism_Homo sapiens_hsa004101.06651799
43Histidine metabolism_Homo sapiens_hsa003401.02885477
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02675480
45Tryptophan metabolism_Homo sapiens_hsa003801.01786411
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00576916
47Type II diabetes mellitus_Homo sapiens_hsa049300.99392344
48Linoleic acid metabolism_Homo sapiens_hsa005910.97977637
49GnRH signaling pathway_Homo sapiens_hsa049120.97312989
50Long-term depression_Homo sapiens_hsa047300.95638473
51Propanoate metabolism_Homo sapiens_hsa006400.94857887
52Fatty acid degradation_Homo sapiens_hsa000710.93913008
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.92840330
54Axon guidance_Homo sapiens_hsa043600.91869068
55Dorso-ventral axis formation_Homo sapiens_hsa043200.91749462
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90209339
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89224089
58Arginine and proline metabolism_Homo sapiens_hsa003300.88804455
59Glucagon signaling pathway_Homo sapiens_hsa049220.88039464
60Protein digestion and absorption_Homo sapiens_hsa049740.86929689
61Pancreatic secretion_Homo sapiens_hsa049720.85488910
62Hedgehog signaling pathway_Homo sapiens_hsa043400.84145153
63TGF-beta signaling pathway_Homo sapiens_hsa043500.78212125
64Bile secretion_Homo sapiens_hsa049760.77245879
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76647612
66Gap junction_Homo sapiens_hsa045400.75122209
67Hippo signaling pathway_Homo sapiens_hsa043900.75096426
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74129311
69Cocaine addiction_Homo sapiens_hsa050300.73375782
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70062357
71Melanogenesis_Homo sapiens_hsa049160.69279240
72Phenylalanine metabolism_Homo sapiens_hsa003600.65042346
73Arginine biosynthesis_Homo sapiens_hsa002200.64134851
74Ovarian steroidogenesis_Homo sapiens_hsa049130.64095533
75Lysine degradation_Homo sapiens_hsa003100.63605666
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63063800
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63002743
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62830140
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62297828
80ECM-receptor interaction_Homo sapiens_hsa045120.60415938
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60399782
82ErbB signaling pathway_Homo sapiens_hsa040120.60027061
83Insulin signaling pathway_Homo sapiens_hsa049100.59808915
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57899874
85Butanoate metabolism_Homo sapiens_hsa006500.57882759
86PPAR signaling pathway_Homo sapiens_hsa033200.57131271
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54437748
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53723398
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53701352
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53541637
91Wnt signaling pathway_Homo sapiens_hsa043100.53301729
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51704619
93Tight junction_Homo sapiens_hsa045300.51644681
94Regulation of autophagy_Homo sapiens_hsa041400.50374539
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50259331
96MAPK signaling pathway_Homo sapiens_hsa040100.49927427
97Starch and sucrose metabolism_Homo sapiens_hsa005000.49891185
98Peroxisome_Homo sapiens_hsa041460.49297145
99Glycerolipid metabolism_Homo sapiens_hsa005610.48621344
100Caffeine metabolism_Homo sapiens_hsa002320.48177177
101Focal adhesion_Homo sapiens_hsa045100.48043520
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46772371
103Choline metabolism in cancer_Homo sapiens_hsa052310.46624040
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46293852
105mTOR signaling pathway_Homo sapiens_hsa041500.45791359
106Adherens junction_Homo sapiens_hsa045200.44817667
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.44647972
108AMPK signaling pathway_Homo sapiens_hsa041520.44375178
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44243582
110Retinol metabolism_Homo sapiens_hsa008300.43389550
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.43087879
112Inositol phosphate metabolism_Homo sapiens_hsa005620.42944165
113Fatty acid elongation_Homo sapiens_hsa000620.42726983
114Thyroid hormone synthesis_Homo sapiens_hsa049180.42494865
115Pyruvate metabolism_Homo sapiens_hsa006200.41607378
116Insulin resistance_Homo sapiens_hsa049310.41321106
117Ras signaling pathway_Homo sapiens_hsa040140.41000238
118Estrogen signaling pathway_Homo sapiens_hsa049150.40260474
119Mineral absorption_Homo sapiens_hsa049780.40123442
120Alzheimers disease_Homo sapiens_hsa050100.38817213
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38566267
122Glioma_Homo sapiens_hsa052140.36057130
123Carbon metabolism_Homo sapiens_hsa012000.35630561
124Rap1 signaling pathway_Homo sapiens_hsa040150.35504028
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35040357
126Melanoma_Homo sapiens_hsa052180.34815889
127Basal cell carcinoma_Homo sapiens_hsa052170.33779741

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